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MCID: SPR009
MIFTS: 45

Sporadic Breast Cancer

Categories: Cancer diseases, Genetic diseases, Immune diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Sporadic Breast Cancer

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MalaCards integrated aliases for Sporadic Breast Cancer:

Name: Sporadic Breast Cancer 12 15
Sporadic Breast Carcinoma 71

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases Rare diseases
Anatomical: Reproductive diseases Skin diseases Immune diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:8029
NCIt 49 C7566
UMLS 71 C1336076
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Summaries for Sporadic Breast Cancer

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Disease Ontology : 12 A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer.

MalaCards based summary : Sporadic Breast Cancer, also known as sporadic breast carcinoma, is related to fanconi anemia, complementation group d2 and familial ovarian cancer. An important gene associated with Sporadic Breast Cancer is BRCA1 (BRCA1 DNA Repair Associated), and among its related pathways/superpathways are Gene Expression and ERK Signaling. Affiliated tissues include breast, testes and endothelial, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

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Related Diseases for Sporadic Breast Cancer

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Diseases in the Breast Cancer family:

Inflammatory Breast Carcinoma Sporadic Breast Cancer
Breast Carcinoma in Situ

Diseases related to Sporadic Breast Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)
# Related Disease Score Top Affiliating Genes
1 fanconi anemia, complementation group d2 30.8 RAD51 FANCD2 BRCA2
2 familial ovarian cancer 30.8 ESR1 BRCA2 BRCA1
3 breast fibroadenoma 30.4 TP53 PGR ESR1 ERBB2 BRCA1
4 breast-ovarian cancer, familial 2 30.4 BRCA2 BRCA1
5 ataxia-telangiectasia 30.4 TP53 FANCD2 CHEK2 BRCA2 BRCA1 ATM
6 mutagen sensitivity 30.4 XRCC1 TP53 CCND1 BRCA2 BRCA1
7 mammographic density 30.3 PGR ESR1
8 cowden syndrome 1 30.3 TP53 PTEN BRCA2 BRCA1
9 peutz-jeghers syndrome 30.3 TP53 PTEN BRCA2
10 in situ carcinoma 30.1 TP53 PTEN PGR ESR1 ERBB2 CCND1
11 papilloma 30.0 TP53 PTEN ESR1 CHEK2 CCND1
12 breast disease 29.8 XRCC1 TP53 PGR MIR146A FHIT ESR2
13 breast ductal carcinoma 29.8 TP53 PTEN PGR ESR2 ESR1 ERBB2
14 nijmegen breakage syndrome 29.7 TP53 RAD51 PTEN FANCD2 CHEK2 BRCA1
15 ductal carcinoma in situ 29.7 TP53 PTEN PGR ESR2 ESR1 ERBB2
16 female breast cancer 29.6 XRCC1 TP53 PGR PALB2 ESR1 ERBB2
17 xeroderma pigmentosum, variant type 29.5 XRCC1 TP53 RAD51 FANCD2 CHEK2 BRCA2
18 glioblastoma multiforme 29.4 TP53 PTEN ESR1 ERBB2 CHEK2 CCND1
19 bladder cancer 29.3 XRCC1 TP53 PTEN MIR146A FHIT ERBB2
20 bilateral breast cancer 29.2 RAD51 PTEN PGR PALB2 FHIT ESR1
21 endometrial cancer 29.2 TP53 RAD51 PTEN PGR ESR2 ESR1
22 fanconi anemia, complementation group a 29.1 XRCC1 TP53 RAD51 PALB2 FANCD2 EMSY
23 cowden syndrome 28.8 TP53 RAD51 PTEN PALB2 ERBB2 CHEK2
24 prostate cancer 28.3 XRCC1 TP53 RAD51 PTEN PGR MIR146A
25 breast cancer 28.3 XRCC1 TTC4 TP53 RAD51 PTEN PGR
26 ovarian cancer 27.8 CHEK2 CCND1 BRCA2 BRCA1 BARD1 ATM
27 fallopian tube clear cell adenocarcinoma 10.7 BRCA2 BRCA1
28 rare malignant breast tumor 10.6 BRCA2 BRCA1
29 ovary transitional cell carcinoma 10.6 BRCA2 BRCA1
30 bartholin's gland adenoid cystic carcinoma 10.6 PGR ESR1
31 chronic tympanitis 10.6 PGR ESR1
32 hereditary site-specific ovarian cancer syndrome 10.6 BRCA2 BRCA1
33 granulomatous endometritis 10.6 PGR ESR1
34 uterine corpus adenosarcoma 10.6 PGR ESR1
35 nonmucinous bronchioloalveolar adenocarcinoma 10.6 ESR2 ESR1
36 vaginal glandular tumor 10.6 PGR ESR1
37 tetraploidy 10.6 BRCA2 BRCA1
38 cancerophobia 10.6 BRCA2 BRCA1
39 synchronous bilateral breast carcinoma 10.6 PGR BRCA2 BRCA1
40 lung leiomyoma 10.6 PGR ESR1
41 esophageal leukoplakia 10.6 TP53 CCND1
42 vulvar syringoma 10.6 PGR ESR1
43 endometrial squamous cell carcinoma 10.6 TP53 PGR
44 trigonitis 10.6 PGR ESR1
45 breast duct papilloma 10.6 PTEN PGR
46 scirrhous adenocarcinoma 10.6 PGR ERBB2
47 bartholin's gland adenoma 10.6 TP53 PGR ESR1
48 bartholin's gland benign neoplasm 10.6 TP53 PGR ESR1
49 vestibular gland benign neoplasm 10.6 TP53 PGR ESR1
50 nosophobia 10.6 BRCA2 BRCA1

Graphical network of the top 20 diseases related to Sporadic Breast Cancer:



Diseases related to Sporadic Breast Cancer
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Symptoms & Phenotypes for Sporadic Breast Cancer

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GenomeRNAi Phenotypes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.43 BARD1 BRCA1 RAD51
2 Decreased homologous recombination repair frequency GR00151-A-2 10.43 BRCA1 RAD51
3 Decreased homologous recombination repair frequency GR00236-A-1 10.43 BARD1 BRCA1 BRCA2 PALB2 RAD51
4 Decreased homologous recombination repair frequency GR00236-A-2 10.43 BARD1 BRCA1 BRCA2 PALB2 RAD51
5 Decreased homologous recombination repair frequency GR00236-A-3 10.43 BARD1 BRCA1 BRCA2 PALB2 RAD51
6 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 10.2 ATM BARD1 CHEK2 TP53
7 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 10.2 ATM BARD1 BRCA1 CCND1 CHEK2 FANCD2
8 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 10.2 ATM BARD1 BRCA1 BRCA2 PALB2 RAD51
9 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.97 BARD1 BRCA1 BRCA2 FANCD2 PALB2 XRCC1
10 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.97 ATM BRCA1 BRCA2 FANCD2 PALB2 TP53
11 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.97 ATM BARD1 BRCA1 BRCA2 CHEK2 FANCD2
12 Decreased viability with cisplatin GR00101-A-4 9.71 BARD1 BRCA1 BRCA2 RAD51
13 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.67 CCND1 ESR1 ESR2 PTEN
14 Increased ionizing radiation sensitivity GR00232-A-1 9.56 ATM BARD1 BRCA1 BRCA2
15 Increased homologous recombination repair frequency GR00236-A-1 9.32 PGR
16 Increased homologous recombination repair frequency GR00236-A-2 9.32 PGR
17 Synthetic lethal with cisplatin GR00101-A-1 9.26 BARD1 BRCA1 BRCA2 RAD51

MGI Mouse Phenotypes related to Sporadic Breast Cancer:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.45 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
2 behavior/neurological MP:0005386 10.38 ATM BRCA1 BRCA2 CCND1 ERBB2 ESR1
3 growth/size/body region MP:0005378 10.34 ATM BARD1 BRCA1 BRCA2 CCND1 ERBB2
4 homeostasis/metabolism MP:0005376 10.33 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
5 endocrine/exocrine gland MP:0005379 10.32 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
6 embryo MP:0005380 10.3 ATM BARD1 BRCA1 BRCA2 ERBB2 ESR1
7 cardiovascular system MP:0005385 10.26 ATM BRCA1 CCND1 ERBB2 ESR1 ESR2
8 hematopoietic system MP:0005397 10.26 ATM BRCA1 BRCA2 CCND1 CHEK2 ESR1
9 mortality/aging MP:0010768 10.25 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
10 immune system MP:0005387 10.21 ATM BRCA1 BRCA2 CCND1 CHEK2 ESR1
11 digestive/alimentary MP:0005381 10.19 BRCA1 BRCA2 CCND1 ERBB2 ESR1 ESR2
12 integument MP:0010771 10.18 ATM BRCA1 BRCA2 CCND1 ERBB2 ESR1
13 neoplasm MP:0002006 10.16 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
14 limbs/digits/tail MP:0005371 10.07 BRCA1 BRCA2 ERBB2 ESR1 ESR2 FANCD2
15 nervous system MP:0003631 10 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
16 normal MP:0002873 9.7 BARD1 BRCA1 BRCA2 CCND1 ERBB2 ESR1
17 reproductive system MP:0005389 9.44 ATM BARD1 BRCA1 BRCA2 CCND1 CHEK2
Sources

Drugs & Therapeutics for Sporadic Breast Cancer

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Syndrome as Modifiable Risk Factor for Breast Cancer Unknown status NCT01172886
2 Prospective Randomized Multicenter Trial to Assess the Efficacy of a Structured Physical Exercise Training and Mediterranean Diet in Women With BRCA1/2 Mutations Recruiting NCT02516540
3 Genetic & Pathological Studies of BRCA1/BRCA2: Associated Tumors & Blood Samples Recruiting NCT01034033
4 Prospective Randomized Multicenter Trial to Assess the Feasibility of a Structured Physical Exercise Training and Mediterranean-style Diet in Women With BRCA1/2 Mutations Active, not recruiting NCT02087592
5 Breast Radiology Evaluation and Study of Tissues (Breast) Stamp Project Active, not recruiting NCT00475761

Search NIH Clinical Center for Sporadic Breast Cancer

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Genetic Tests for Sporadic Breast Cancer

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Anatomical Context for Sporadic Breast Cancer

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MalaCards organs/tissues related to Sporadic Breast Cancer:

40
Breast, Testes, Endothelial, Prostate, Thyroid, Lymph Node, Brain
Sources

Publications for Sporadic Breast Cancer

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Articles related to Sporadic Breast Cancer:

(show top 50) (show all 880)
# Title Authors PMID Year
1
Evaluation of non-coding region sequence variants and mitochondrial haplogroups as potential biomarkers of sporadic breast cancer in individuals of Sri Lankan Sinhalese ethnicity. 61
32346478 2020
2
Breast Conserving Surgery for BRCA Mutation Carriers-A Systematic Review. 61
32144082 2020
3
What surgical oncology providers and women with sporadic breast cancer should not forget in the decision-making about contralateral prophylactic mastectomy! 61
30698813 2020
4
Study of DOK4 gene expression and promoter methylation in sporadic breast cancer. 61
32386480 2020
5
Discussions about contralateral prophylactic mastectomy among surgical oncology providers and women with sporadic breast cancer: a content analysis. 61
30561744 2020
6
Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients. 61
32397691 2020
7
BRCA1/BRCA2 Pathogenic Variant Breast Cancer: Treatment and Prevention Strategies. 61
31650727 2020
8
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia. 61
32192442 2020
9
BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer. 61
32235500 2020
10
miRNA expression profiling of hereditary breast tumors from BRCA1- and BRCA2-germline mutation carriers in Brazil. 61
32087690 2020
11
Prognosis of BRCA1/2-negative breast cancer patients with HBOC risk factors compared with sporadic breast cancer patients without HBOC risk factors. 61
31926487 2020
12
Epstein-Barr Virus Infection and Increased Sporadic Breast Carcinoma Risk: A Meta-Analysis. 61
31311020 2020
13
A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population. 61
32142098 2020
14
Comparison of clinical features and oncologic outcomes between familial (non-hereditary) and hereditary breast cancer in Korean female patients. 61
31924417 2020
15
Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer Pathogenesis. 61
32013256 2020
16
How Computational Experiments Can Improve Our Understanding of the Genetic Architecture of Common Human Diseases. 61
32027528 2020
17
Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) variants and breast cancer risk in Burkina Faso. 61
31707358 2019
18
Population prevalence of individuals meeting criteria for hereditary breast and ovarian cancer testing. 61
31531966 2019
19
Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain). 61
31771539 2019
20
Mouse mammary tumor virus (MMTV) - like exogenous sequences are associated with sporadic but not hereditary human breast carcinoma. 61
31518337 2019
21
Association of MIR146A rs2910164 variation with a predisposition to sporadic breast cancer in a Pakistani cohort. 61
30963551 2019
22
Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population. 61
30810967 2019
23
A Multi-Center Study of BRCA1 and BRCA2 Germline Mutations in Mexican-Mestizo Breast Cancer Families Reveals Mutations Unreported in Latin American Population. 61
31454914 2019
24
Electrophoretic mobility shift assays implicate XRCC2:rs3218550C>T as a potential low-penetrant susceptibility allele for sporadic breast cancer. 61
31370865 2019
25
Genotype data for single nucleotide polymorphism markers in sporadic breast cancer related genes in a Sri Lankan case-control cohort of postmenopausal women. 61
31324265 2019
26
Analysis of the pathogenic variants of BRCA1 and BRCA2 using next-generation sequencing in women with familial breast cancer: a case-control study. 61
31331294 2019
27
Novel BRCA2 pathogenic variant c.5219 T > G; p.(Leu1740Ter) in a consanguineous Senegalese family with hereditary breast cancer. 61
31060517 2019
28
Associations between XRCC3 Thr241Met polymorphisms and breast cancer risk: systematic-review and meta-analysis of 55 case-control studies. 61
31077156 2019
29
Expression and prognostic significance of Fanconi anemia group D2 protein and breast cancer type 1 susceptibility protein in familial and sporadic breast cancer. 61
30881493 2019
30
BRCA1 mutation in breast cancer patients: Analysis of prognostic factors and survival. 61
30675265 2019
31
PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer Patients 61
30678449 2019
32
A systematic review of the international prevalence of BRCA mutation in breast cancer. 61
31372057 2019
33
Breast Cancer in BRCA1/2 Mutation Carriers - Do We Treat It Differently? Focus on Systemic Therapy for BRCA1/2 Associated Breast Cancer. 61
31409078 2019
34
Deleterious Mutations in DNA Repair Gene FANCC Exist in BRCA1/2-Negative Chinese Familial Breast and/or Ovarian Cancer Patients. 61
30967997 2019
35
Plant natural modulators in breast cancer prevention: status quo and future perspectives reinforced by predictive, preventive, and personalized medical approach. 61
30538792 2018
36
Novel Clofarabine-Based Combinations with Polyphenols Epigenetically Reactivate Retinoic Acid Receptor Beta, Inhibit Cell Growth, and Induce Apoptosis of Breast Cancer Cells. 61
30544666 2018
37
Association analysis of interleukin-18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women. 61
29926984 2018
38
Incidence of Breast Cancer in the Life Span Study of Atomic Bomb Survivors: 1958-2009. 61
30044713 2018
39
Streamlining Decision Making in Contralateral Risk-Reducing Mastectomy: Impact of PREDICT and BOADICEA Computations. 61
30019305 2018
40
Sporadic and Hereditary Breast Cancer Genetics. 61
30352929 2018
41
BRCA1 Promoter Methylation and Clinicopathological Characteristics in Sporadic Breast Cancer Patients in Indonesia 61
30256562 2018
42
Aberrant Promoter Methylation of YAP Gene and its Subsequent Downregulation in Indian Breast Cancer Patients. 61
29970036 2018
43
Mutant p53 gain of function induces HER2 over-expression in cancer cells. 61
29970031 2018
44
Genetic Variants Associated with Clinicopathological Profiles in Sporadic Breast Cancer in Sri Lankan Women. 61
29963112 2018
45
Somatic BRCA1 mutations in clinically sporadic breast cancer with medullary histological features. 61
29453630 2018
46
EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer. 61
29661238 2018
47
Proteomics Analysis to Assess the Role of Mitochondria in BRCA1-Mediated Breast Tumorigenesis. 61
29584711 2018
48
CHEK2 Germ Line Mutations are Lacking among Familial and Sporadic Breast Cancer Patients in Rwanda 61
29479983 2018
49
Genetic determinants of sporadic breast cancer in Sri Lankan women. 61
29433565 2018
50
Management of hereditary breast and ovarian cancer. 61
29185095 2018
Sources

Variations for Sporadic Breast Cancer

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Expression for Sporadic Breast Cancer

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Search GEO for disease gene expression data for Sporadic Breast Cancer.
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Pathways for Sporadic Breast Cancer

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Pathways related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Gene Expression 65
Show member pathways
 13.84 TP53 PTEN PGR FANCD2 ESR2 ESR1
2
ERK Signaling 63
Show member pathways
 13.84 TP53 RAD51 PTEN FANCD2 ESR2 ESR1
3
Cell Cycle, Mitotic 65
Show member pathways
 13.45 TP53 RAD51 CHEK2 CCND1 BRCA2 BRCA1
4
DNA Double-Strand Break Repair 65
Show member pathways
 13.24 XRCC1 TP53 RAD51 PALB2 FANCD2 CHEK2
5
PI3K-Akt signaling pathway 36
Show member pathways
 13.01 TP53 PTEN ERBB2 CCND1 BRCA1 ATM
6
Regulation of TP53 Activity 65
Show member pathways
 13 TP53 PTEN FANCD2 CHEK2 BRCA1 BARD1
7
TCR Signaling (Qiagen) 63
Show member pathways
 12.98 TP53 RAD51 FANCD2 CHEK2 BRCA2 BRCA1
8
Endometrial cancer 36
Show member pathways
 12.9 TP53 RAD51 PTEN ERBB2 CCND1 BRCA2
9
Pathways in cancer 36
12.89 TP53 RAD51 PTEN ESR2 ESR1 ERBB2
10
Deubiquitination 65
Show member pathways
 12.84 TP53 PTEN ESR1 BRCA1 BARD1
11
Gastric cancer 36
Show member pathways
 12.81 TP53 PTEN PGR ESR2 ESR1 ERBB2
12
Cell Cycle Checkpoints 65
Show member pathways
 12.66 TP53 CHEK2 BRCA1 BARD1 ATM
13
Glioma 36
Show member pathways
 12.66 TP53 PTEN FHIT ESR2 ESR1 ERBB2
14
MicroRNAs in cancer 36
12.59 TP53 PTEN MIR146A ERBB2 CCND1 BRCA1
15
DNA Damage 4
12.53 XRCC1 TP53 RAD51 FANCD2 CHEK2 CCND1
16
Prolactin Signaling Pathway 36 1
Show member pathways
 12.52 PTEN ESR2 ESR1 ERBB2 CCND1
17
Apoptosis Pathway 70
Show member pathways
 12.45 TP53 ERBB2 CHEK2 ATM
18
DNA Damage Response 1
Show member pathways
 12.43 TP53 RAD51 PTEN FANCD2 CHEK2 CCND1
19
DNA Double Strand Break Response 65
Show member pathways
 12.41 TP53 CHEK2 BRCA1 BARD1 ATM
20
Cell cycle 36 1
12.38 TP53 CHEK2 CCND1 ATM
21
Human T-cell leukemia virus 1 infection 36
12.38 TP53 PTEN CHEK2 CCND1 ATM
22
Homologous DNA Pairing and Strand Exchange 65
Show member pathways
 12.36 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
23
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.34 ESR2 ESR1 ERBB2 CCND1
24
Chks in Checkpoint Regulation 63
Show member pathways
 12.34 XRCC1 TP53 RAD51 FANCD2 ESR2 ESR1
25
Translation Non-genomic (rapid) action of Androgen Receptor 22
Show member pathways
 12.33 TP53 PTEN ERBB2 CCND1
26
Proteoglycans in cancer 36
12.32 TP53 ESR1 ERBB2 CCND1
27
p53 Signaling 63
Show member pathways
 12.32 TP53 PTEN CHEK2 CCND1 BRCA1 ATM
28
Cell cycle Role of SCF complex in cell cycle regulation 22
Show member pathways
 12.27 PGR ESR1 CHEK2 CCND1 BRCA1
29
Cellular senescence (KEGG) 36
12.21 TP53 PTEN CHEK2 CCND1 ATM
30
Resolution of D-loop Structures through Holliday Junction Intermediates 65
Show member pathways
 12.2 RAD51 PALB2 BRCA2 BRCA1 BARD1 ATM
31
DNA Damage Response (only ATM dependent) 1
12.07 TP53 PTEN ERBB2 CCND1 ATM
32
Fanconi anemia pathway 65 36
11.96 RAD51 PALB2 FANCD2 BRCA2 BRCA1
33
ATM Pathway 63
Show member pathways
 11.93 TP53 RAD51 FANCD2 CHEK2 BRCA1 ATM
34
Small cell lung cancer 36
11.92 TP53 PTEN FHIT CCND1
35
Androgen receptor signaling pathway 1
11.87 PTEN CCND1 BRCA1
36
Nuclear Receptor transcription pathway 65
Show member pathways
 11.86 PGR ESR2 ESR1
37
Retinoblastoma (RB) in Cancer 1
11.85 TP53 CCND1 BARD1
38
Platinum drug resistance 36
11.79 TP53 ERBB2 BRCA1 ATM
39
Pathways Affected in Adenoid Cystic Carcinoma 1
11.77 TP53 PTEN ERBB2 CHEK2 BRCA1 ATM
40
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.76 TP53 CHEK2 ATM
41
E2F transcription factor network 1
11.76 XRCC1 BRCA1 ATM
42
Bladder cancer 36 1
11.76 TP53 ERBB2 CCND1
43
Central carbon metabolism in cancer 36
11.74 TP53 PTEN ERBB2
44
Regulation of Telomerase 1
11.71 ESR1 CCND1 ATM
45
BRCA1 Pathway 63
Show member pathways
 11.68 TP53 RAD51 FANCD2 CHEK2 BRCA2 BRCA1
46
Validated targets of C-MYC transcriptional repression 1
11.67 ERBB2 CCND1 BRCA1
47
p53 pathway 1
11.65 TP53 CHEK2 ATM
48
Copper homeostasis 1
11.61 TP53 PTEN CCND1
49
Hepatitis C and Hepatocellular Carcinoma 1
11.58 TP53 CCND1 BRCA1
50
miRNAs involved in DNA damage response 1
11.57 TP53 CCND1 ATM
Sources

GO Terms for Sporadic Breast Cancer

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Cellular components related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.95 XRCC1 TP53 RAD51 PGR ESR2 ESR1
2 nucleus GO:0005634 9.93 XRCC1 TTC4 TP53 RAD51 PTEN PGR
3 host cell nucleus GO:0042025 9.73 PGR ESR2 ESR1 CCND1
4 nuclear chromosome, telomeric region GO:0000784 9.67 XRCC1 RAD51 BRCA2 ATM
5 PML body GO:0016605 9.56 TP53 RAD51 PTEN CHEK2
6 nucleoplasm GO:0005654 9.55 XRCC1 TTC4 TP53 RAD51 PTEN PGR
7 condensed chromosome GO:0000793 9.5 RAD51 FANCD2 BRCA1
8 BRCA1-A complex GO:0070531 9.46 BRCA1 BARD1
9 BRCA1-BARD1 complex GO:0031436 9.4 BRCA1 BARD1
10 lateral element GO:0000800 9.33 RAD51 BRCA2 BRCA1

Biological processes related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 10.12 TP53 PTEN FHIT CHEK2 BRCA1 ATM
2 positive regulation of transcription, DNA-templated GO:0045893 10.09 TP53 ESR2 ESR1 CHEK2 BRCA2 BRCA1
3 cell cycle GO:0007049 10.09 TP53 FANCD2 CHEK2 CCND1 BRCA2 BRCA1
4 positive regulation of gene expression GO:0010628 10.05 TP53 PTEN MIR146A ERBB2 BRCA1 ATM
5 positive regulation of apoptotic process GO:0043065 10.03 TP53 PTEN MIR146A BARD1 ATM
6 response to drug GO:0042493 10 XRCC1 TP53 RAD51 PTEN CCND1
7 regulation of apoptotic process GO:0042981 9.99 TP53 ESR1 BRCA1 ATM
8 protein deubiquitination GO:0016579 9.99 TP53 PTEN ESR1 BRCA1 BARD1
9 heart development GO:0007507 9.98 TP53 PTEN ERBB2 ATM
10 regulation of cell cycle GO:0051726 9.91 TP53 PTEN CCND1 ATM
11 transcription initiation from RNA polymerase II promoter GO:0006367 9.89 PTEN PGR ESR2 ESR1 CCND1
12 response to organic substance GO:0010033 9.87 XRCC1 PTEN CCND1
13 DNA recombination GO:0006310 9.87 RAD51 PALB2 BRCA2 BRCA1
14 multicellular organism growth GO:0035264 9.86 TP53 PALB2 ATM
15 response to estrogen GO:0043627 9.83 ESR1 CCND1 BRCA1
16 double-strand break repair via nonhomologous end joining GO:0006303 9.83 XRCC1 BRCA1 BARD1 ATM
17 regulation of signal transduction by p53 class mediator GO:1901796 9.83 TP53 CHEK2 BRCA1 BARD1 ATM
18 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.82 TP53 CHEK2 ATM
19 somitogenesis GO:0001756 9.81 TP53 PALB2 ATM
20 double-strand break repair GO:0006302 9.81 TP53 CHEK2 BRCA2 BRCA1
21 response to ionizing radiation GO:0010212 9.79 RAD51 BRCA1 ATM
22 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.76 TP53 CHEK2 BRCA2
23 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.76 CHEK2 BRCA2 BRCA1 ATM
24 DNA double-strand break processing GO:0000729 9.71 BRCA1 BARD1 ATM
25 cellular response to gamma radiation GO:0071480 9.71 TP53 RAD51 CHEK2 ATM
26 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.68 TP53 ESR1
27 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.68 TP53 ESR1
28 protein K6-linked ubiquitination GO:0085020 9.67 BRCA1 BARD1
29 telomere maintenance via recombination GO:0000722 9.67 RAD51 BRCA2
30 chromosome organization involved in meiotic cell cycle GO:0070192 9.67 RAD51 ATM
31 response to gamma radiation GO:0010332 9.67 TP53 FANCD2 CHEK2 BRCA2
32 regulation of toll-like receptor signaling pathway GO:0034121 9.66 MIR146A ESR1
33 mitotic G1 DNA damage checkpoint GO:0031571 9.66 TP53 CCND1
34 DNA damage induced protein phosphorylation GO:0006975 9.65 CHEK2 ATM
35 replicative senescence GO:0090399 9.65 TP53 CHEK2 ATM
36 DNA repair GO:0006281 9.65 XRCC1 RAD51 PALB2 FANCD2 EMSY CHEK2
37 replication-born double-strand break repair via sister chromatid exchange GO:1990414 9.63 XRCC1 RAD51
38 double-strand break repair via homologous recombination GO:0000724 9.63 XRCC1 RAD51 PALB2 BRCA2 BRCA1 ATM
39 chordate embryonic development GO:0043009 9.62 BRCA2 BRCA1
40 response to X-ray GO:0010165 9.62 TP53 RAD51 CCND1 BRCA2
41 mitotic recombination-dependent replication fork processing GO:1990426 9.56 RAD51 BRCA2
42 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.56 TP53 CHEK2 BRCA2 BRCA1
43 cellular response to DNA damage stimulus GO:0006974 9.4 XRCC1 TP53 RAD51 PALB2 FANCD2 EMSY

Molecular functions related to Sporadic Breast Cancer according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 10.13 TP53 RAD51 PGR PALB2 ESR2 ESR1
2 protein binding GO:0005515 10.13 XRCC1 TTC4 TP53 RAD51 PTEN PGR
3 protein kinase binding GO:0019901 9.89 TP53 PTEN ESR1 CHEK2 CCND1
4 steroid hormone receptor activity GO:0003707 9.63 PGR ESR2 ESR1
5 repressing transcription factor binding GO:0070491 9.61 PGR ESR2 ESR1
6 enzyme binding GO:0019899 9.61 XRCC1 TP53 RAD51 PTEN PGR ESR2
7 nuclear receptor activity GO:0004879 9.54 PGR ESR2 ESR1
8 identical protein binding GO:0042802 9.44 TP53 RAD51 PTEN PGR FHIT ESR2
9 steroid binding GO:0005496 9.43 PGR ESR2 ESR1
10 estrogen receptor activity GO:0030284 9.4 ESR2 ESR1
11 estrogen response element binding GO:0034056 9.32 ESR2 ESR1
Sources

Sources for Sporadic Breast Cancer

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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