MCID: SPR083
MIFTS: 36

Sporadic Hemiplegic Migraine

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Sporadic Hemiplegic Migraine

MalaCards integrated aliases for Sporadic Hemiplegic Migraine:

Name: Sporadic Hemiplegic Migraine 25
Migraine, Sporadic Hemiplegic 29 6 73
Non-Familial Hemiplegic Migraine 25 73
Sporadic Hemiplegic Migraines 73
Shm 25

Classifications:



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Summaries for Sporadic Hemiplegic Migraine

Genetics Home Reference : 25 Sporadic hemiplegic migraine is a rare form of migraine headache. Migraines typically cause intense, throbbing pain in one area of the head. Some people with migraines also experience nausea, vomiting, and sensitivity to light and sound. These recurrent headaches typically begin in childhood or adolescence and can be triggered by certain foods, emotional stress, and minor head trauma. Each headache may last from a few hours to a few days.

MalaCards based summary : Sporadic Hemiplegic Migraine, also known as migraine, sporadic hemiplegic, is related to familial or sporadic hemiplegic migraine and hemiplegic migraine. An important gene associated with Sporadic Hemiplegic Migraine is CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Synaptic vesicle cycle. The drugs Topiramate and Neuroprotective Agents have been mentioned in the context of this disorder. Affiliated tissues include testes and brain, and related phenotypes are normal and respiratory system

Related Diseases for Sporadic Hemiplegic Migraine

Graphical network of the top 20 diseases related to Sporadic Hemiplegic Migraine:



Diseases related to Sporadic Hemiplegic Migraine

Symptoms & Phenotypes for Sporadic Hemiplegic Migraine

MGI Mouse Phenotypes related to Sporadic Hemiplegic Migraine:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.13 ATP1A2 CACNA1A SCN1A
2 respiratory system MP:0005388 8.8 ATP1A2 CACNA1A SCN1A

Drugs & Therapeutics for Sporadic Hemiplegic Migraine

Drugs for Sporadic Hemiplegic Migraine (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Topiramate Approved Phase 2 97240-79-4 5284627
2 Neuroprotective Agents Phase 2
3 Anticonvulsants Phase 2
4 Anti-Obesity Agents Phase 2
5 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Continuous Treatment Study of Topiramate in Migraine Participants Completed NCT01799590 Phase 2 Topiramate

Search NIH Clinical Center for Sporadic Hemiplegic Migraine

Genetic Tests for Sporadic Hemiplegic Migraine

Genetic tests related to Sporadic Hemiplegic Migraine:

# Genetic test Affiliating Genes
1 Migraine, Sporadic Hemiplegic 29

Anatomical Context for Sporadic Hemiplegic Migraine

MalaCards organs/tissues related to Sporadic Hemiplegic Migraine:

41
Testes, Brain

Publications for Sporadic Hemiplegic Migraine

Articles related to Sporadic Hemiplegic Migraine:

(show top 50) (show all 58)
# Title Authors Year
1
A Novel ATP1A2 Gene Variant Associated With Pure Sporadic Hemiplegic Migraine Improved After Patent Foramen Ovale Closure: A Case Report. ( 29867740 )
2018
2
Pediatric sporadic hemiplegic migraine (ATP1A2 gene): a case report and brief literature review. ( 29904856 )
2018
3
Stroke-like attack: first episode of sporadic hemiplegic migraine. ( 28527090 )
2017
4
Intermittent Theta Slowings in Contralateral Side of Weakness after Sleep Deprivation on Spot EEG in Sporadic Hemiplegic Migraine. ( 28101483 )
2016
5
Clinical and electroencephalographic abnormalities during the full duration of a sporadic hemiplegic migraine attack. ( 27155821 )
2016
6
Sporadic hemiplegic migraine and giant tumefactive perivascular space: Is there an association? ( 26696413 )
2015
7
A case report of sporadic hemiplegic migraine associated cerebral hypoperfusion: comparison of arterial spin labeling and dynamic susceptibility contrast perfusion MR imaging. ( 26250760 )
2015
8
Functional analysis of human Na(+)/K(+)-ATPase familial or sporadic hemiplegic migraine mutations expressed in Xenopus oocytes. ( 24921013 )
2014
9
Changes in (99m)Tc-ECD SPECT and magnetic resonance angiography with sporadic hemiplegic migraine in a child. ( 24662647 )
2014
10
Arterial surgery for sporadic hemiplegic migraine: preliminary results. ( 24703384 )
2014
11
Sporadic hemiplegic migraine with permanent neurological deficits. ( 24117121 )
2014
12
A pediatric sporadic hemiplegic migraine case with perfusion abnormality in perfusion MRI and Diamox 99mTc-HMPAO SPECT. ( 22547402 )
2013
13
May a suspicious psychiatric disorder hide sporadic hemiplegic migraine? Genetic test as prompting factor for diagnosis. ( 23397224 )
2013
14
Sporadic Hemiplegic Migraine with ATP1A2 and Prothrombin Gene Mutations. ( 24396618 )
2013
15
Sporadic hemiplegic migraine in a Nigerian woman. ( 24005593 )
2013
16
The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. ( 23766355 )
2013
17
Familial and sporadic hemiplegic migraine: diagnosis and treatment. ( 23203776 )
2013
18
Transient unilateral spatial neglect during aura in a woman with sporadic hemiplegic migraine. ( 23674829 )
2013
19
Rare clinical findings in a patient with sporadic hemiplegic migraine: FDG-PET provides diminished brain metabolism at 10-year follow-up. ( 24270521 )
2013
20
Migraine-induced epistaxis and sporadic hemiplegic migraine: unusual features in the same patient. ( 22807908 )
2012
21
Prolonged symptoms in sporadic hemiplegic migraine: aura or migrainous infarction? ( 23196733 )
2012
22
Sporadic hemiplegic migraine presenting as acute encephalopathy. ( 22136990 )
2012
23
Sporadic hemiplegic migraine with normal imaging as the initial manifestation of CADASIL. ( 22250206 )
2012
24
Sporadic hemiplegic migraine. ( 22410518 )
2012
25
Prolonged sporadic hemiplegic migraine associated with a novel de novo missense ATP1A2 gene mutation. ( 21352219 )
2011
26
The genetic features of 24 patients affected by familial and sporadic hemiplegic migraine. ( 21533730 )
2011
27
Multimodal neuroimaging in a child with sporadic hemiplegic migraine: a contribution to understanding pathogenesis. ( 21172953 )
2011
28
A long-term follow-up study of 18 patients with sporadic hemiplegic migraine. ( 20974584 )
2011
29
Sporadic hemiplegic migraine with seizures and transient MRI abnormalities. ( 22937333 )
2011
30
One case of sporadic hemiplegic migraine with multiple pulmonary arteriovenous malformation. ( 21246241 )
2011
31
Sporadic hemiplegic migraine and epilepsy associated with CACNA1A gene mutation. ( 20071244 )
2010
32
De novo mutations in ATP1A2 and CACNA1A are frequent in early-onset sporadic hemiplegic migraine. ( 20837964 )
2010
33
Sporadic hemiplegic migraine in children: a report of two new cases. ( 20739815 )
2010
34
Sporadic hemiplegic migraine and CREST syndrome. ( 20130953 )
2010
35
Sporadic hemiplegic migraine and delayed cerebral oedema after minor head trauma: a novel de novo CACNA1A gene mutation. ( 19811514 )
2010
36
Sporadic hemiplegic migraine in children. ( 20739784 )
2010
37
Migrainous infarction as a complication of sporadic hemiplegic migraine in childhood. ( 19838529 )
2009
38
A case of atypical sporadic hemiplegic migraine associated with PFO and hypoplasia of vertebro-basilar system. ( 19421707 )
2009
39
Cessation of sporadic hemiplegic migraine attacks after patent foramen ovale closure. ( 19758362 )
2009
40
[Familial and sporadic hemiplegic migraine]. ( 18405771 )
2008
41
Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients. ( 18513263 )
2008
42
A novel de novo nonsense mutation in ATP1A2 associated with sporadic hemiplegic migraine and epileptic seizures. ( 18644608 )
2008
43
Sporadic hemiplegic migraine: report of a case with clinical and radiological features. ( 18810316 )
2008
44
Amino acid changes in the amino terminus of the Na,K-adenosine triphosphatase alpha-2 subunit associated to familial and sporadic hemiplegic migraine. ( 17877748 )
2007
45
Implication of augmented vasogenic leakage in the mechanism of persistent aura in sporadic hemiplegic migraine. ( 16472342 )
2006
46
Minor head trauma-induced sporadic hemiplegic migraine coma. ( 16638514 )
2006
47
Imaging abnormalities in sporadic hemiplegic migraine on conventional MRI, diffusion and perfusion MRI and MRS. ( 16886937 )
2006
48
Symptomatic sporadic hemiplegic migraine. ( 16232163 )
2005
49
Sporadic hemiplegic migraine. ( 15566415 )
2004
50
Sporadic hemiplegic migraine. ( 15115642 )
2004

Variations for Sporadic Hemiplegic Migraine

ClinVar genetic disease variations for Sporadic Hemiplegic Migraine:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CACNA1A NM_001127221.1(CACNA1A): c.1748G> A (p.Arg583Gln) single nucleotide variant Pathogenic rs121908217 GRCh37 Chromosome 19, 13419266: 13419266
2 CACNA1A NM_001127221.1(CACNA1A): c.1748G> A (p.Arg583Gln) single nucleotide variant Pathogenic rs121908217 GRCh38 Chromosome 19, 13308452: 13308452

Expression for Sporadic Hemiplegic Migraine

Search GEO for disease gene expression data for Sporadic Hemiplegic Migraine.

Pathways for Sporadic Hemiplegic Migraine

Pathways related to Sporadic Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.55 ATP1A2 SCN1A
2
Show member pathways
10.68 ATP1A2 CACNA1A

GO Terms for Sporadic Hemiplegic Migraine

Cellular components related to Sporadic Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.16 CACNA1A SCN1A
2 intercalated disc GO:0014704 8.96 ATP1A2 SCN1A
3 T-tubule GO:0030315 8.62 ATP1A2 SCN1A

Biological processes related to Sporadic Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.43 ATP1A2 CACNA1A SCN1A
2 regulation of ion transmembrane transport GO:0034765 9.4 CACNA1A SCN1A
3 sodium ion transport GO:0006814 9.37 ATP1A2 SCN1A
4 regulation of membrane potential GO:0042391 9.32 CACNA1A SCN1A
5 membrane depolarization during action potential GO:0086010 9.16 CACNA1A SCN1A
6 adult walking behavior GO:0007628 8.96 CACNA1A SCN1A
7 ion transmembrane transport GO:0034220 8.8 ATP1A2 CACNA1A SCN1A

Molecular functions related to Sporadic Hemiplegic Migraine according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.16 CACNA1A SCN1A
2 voltage-gated ion channel activity GO:0005244 8.96 CACNA1A SCN1A
3 cation channel activity GO:0005261 8.62 CACNA1A SCN1A

Sources for Sporadic Hemiplegic Migraine

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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