MCID: SPR010
MIFTS: 46

Sporotrichosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 77 54 60 45 15 17 74 3
Rose Gardener's Disease 54

Characteristics:

Orphanet epidemiological data:

60
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD9CM 36 117.1
MeSH 45 D013174
SNOMED-CT 69 42094007
ICD10 34 B42 B42.9
MESH via Orphanet 46 D013174
ICD10 via Orphanet 35 B42.0 B42.1 B42.7 more
UMLS via Orphanet 75 C0038034
Orphanet 60 ORPHA826
UMLS 74 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to syphilis and secondary syphilis. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are T cell receptor signaling pathway and Immune response NFAT in immune response. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain, and related phenotype is integument.

CDC : 3 Photomicrograph showing Sporothrix schenckii.

Wikipedia : 77 Sporotrichosis is a disease caused by the infection of the fungus Sporothrix schenckii. This fungal... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 syphilis 30.3 CD40LG CD79A
2 secondary syphilis 30.3 CD40LG CD79A
3 lepromatous leprosy 30.3 IFNG IL10
4 human immunodeficiency virus infectious disease 30.2 IFNG IL10
5 osteomyelitis 30.2 IFNG IL10
6 cutaneous leishmaniasis 29.9 IFNG IL10
7 ulcerative colitis 29.7 BTNL2 IFNG IL10
8 colitis 29.7 BTNL2 IFNG IL10
9 cow milk allergy 10.3 CD79A IL10
10 milk allergy 10.3 CD79A IL10
11 cephalosporin allergy 10.3 IFNG IL10
12 hyperlucent lung 10.3 IFNG IL10
13 nickel allergic contact dermatitis 10.3 IFNG IL10
14 allergic contact dermatitis 10.3 IFNG IL10
15 contact dermatitis 10.3 IFNG IL10
16 baylisascariasis 10.3 IFNG IL10
17 pericardial tuberculosis 10.3 IFNG IL10
18 tuberculoid leprosy 10.3 IFNG IL10
19 lipoid nephrosis 10.3 CD79A IL10
20 multicentric castleman disease 10.3 IFNG IL10
21 castleman disease 10.3 IFNG IL10
22 chronic active epstein-barr virus infection 10.3 IFNG IL10
23 peanut allergy 10.3 IFNG IL10
24 fascioliasis 10.3 IFNG IL10
25 intermediate uveitis 10.3 IFNG IL10
26 primary systemic mycosis 10.3 IFNG IL10
27 hand, foot and mouth disease 10.3 IFNG IL10
28 mycoplasma pneumoniae pneumonia 10.3 IFNG IL10
29 poliomyelitis 10.3 IFNG IL10
30 arthritis 10.3
31 eales disease 10.3 IFNG IL10
32 strongyloidiasis 10.3 CD79A IFNG
33 spotted fever 10.3 IFNG IL10
34 coccidiosis 10.3 IFNG IL10
35 microscopic colitis 10.3 CD79A IFNG
36 hematopoietic stem cell transplantation 10.3 IFNG IL10
37 keratoconjunctivitis sicca 10.3 CD79A IL10
38 aseptic meningitis 10.3 IFNG IL10
39 primary peritoneal carcinoma 10.3 IFNG IL10
40 plasmodium vivax malaria 10.3 IFNG IL10
41 c1q nephropathy 10.3 CD40LG CD79A
42 polyradiculoneuropathy 10.3 IFNG IL10
43 immunoglobulin g deficiency 10.3 CD40LG CD79A
44 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3 IFNG IL10
45 cryofibrinogenemia 10.3 CD40LG CD79A
46 extrapulmonary tuberculosis 10.3 IFNG IL10
47 paranasal sinus disease 10.3 IFNG IL10
48 heparin-induced thrombocytopenia 10.3 CD40LG CD79A
49 immunoglobulin a deficiency 1 10.3 CD40LG CD79A
50 congenital syphilis 10.3 CD40LG CD79A

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

MGI Mouse Phenotypes related to Sporotrichosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.02 BRSK2 CD40LG IFNG IL10 MOGS

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
5 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
6 Hormones Phase 2,Phase 1
7 Anti-Infective Agents Phase 2,Phase 1
8 Steroid Synthesis Inhibitors Phase 2,Phase 1
9 Hormone Antagonists Phase 2,Phase 1
10 Antifungal Agents Phase 2,Phase 1
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
13
Hydroxyitraconazole Phase 1, Phase 2
14 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

42
Skin, Bone, Brain, Testes, Eye, T Cells, Monocytes

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 963)
# Title Authors Year
1
"Osteoarticular Sporotrichosis vs. Rheumatoid Arthritis: A Tale of Two Granulomatous Arthritides". ( 30904507 )
2019
2
Facial Cutaneous Sporotrichosis in a Boy. ( 30527560 )
2019
3
Cutaneous sporotrichosis in a stray cat from Thailand. ( 30619683 )
2019
4
Effects of metaperiodate and urea solutions on the serological diagnosis of human sporotrichosis using an indirect ELISA test. ( 30637654 )
2019
5
Sporotrichosis In Immunocompromised Hosts. ( 30641918 )
2019
6
Electrosurgery as Adjuvant Therapy for Cutaneous Sporotrichosis. ( 30664002 )
2019
7
An atypical cause of sporotrichosis in a cat. ( 30723664 )
2019
8
Sporotrichosis. ( 30786190 )
2019
9
Fast diagnosis of sporotrichosis caused by Sporothrix globosa, Sporothrix schenckii, and Sporothrix brasiliensis based on multiplex real-time PCR. ( 30817761 )
2019
10
Squamous cell carcinoma subsequent to scarring caused by sporotrichosis: A case report. ( 30846316 )
2019
11
Correction to: Effects of metaperiodate and urea solutions on the serological diagnosis of human sporotrichosis using an indirect ELISA test. ( 30874967 )
2019
12
Sporotrichosis by<i>Sporothrix schenckii</i>senso stricto with itraconazole resistance and terbinafine sensitivity observed<i>in vitro</i>and<i>in vivo</i>: Case report. ( 29204336 )
2018
13
Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia. ( 29903814 )
2018
14
Endophthalmitis in patients co-infected by HIV and sporotrichosis: a systematic review of published case reports. ( 29880916 )
2018
15
Sporotrichosis: From KOH to Molecular Biology. ( 29882883 )
2018
16
Case of pyoderma gangrenosum-like sporotrichosis caused by Sporothrix globosa in a patient with ulcerative colitis. ( 29488248 )
2018
17
Sporotrichin Skin Test for the Diagnosis of Sporotrichosis. ( 29747377 )
2018
18
Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women. ( 29684015 )
2018
19
Successful treatment outcome with itraconazole and potassium iodide in disseminated sporotrichosis. ( 29210361 )
2018
20
Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats. ( 29729723 )
2018
21
Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. ( 29538731 )
2018
22
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. ( 29899416 )
2018
23
The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement Comment on &amp;quot;Dermoscopy in disseminated sporotrichosis&amp;quot;. ( 29953679 )
2018
24
Image Gallery: Facial sporotrichosis. ( 29668090 )
2018
25
Refractory feline sporotrichosis treated with itraconazole combined with potassium iodide. ( 29708594 )
2018
26
An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis. ( 29520092 )
2018
27
A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis. ( 29952302 )
2018
28
Dermoscopy in disseminated sporotrichosis. ( 29953691 )
2018
29
Sporotrichosis in the nail-An unusual location and presentation. ( 29387746 )
2018
30
Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. ( 29412358 )
2018
31
The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy. ( 29559998 )
2018
32
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis. ( 29440688 )
2018
33
Primary conjunctival sporotrichosis: An atypical presentation of the disease. ( 29984295 )
2018
34
Sporotrichosis in Southern Brazil, towards an epidemic? ( 30009528 )
2018
35
A case of disseminated sporotrichosis caused by Sporothrix brasiliensis. ( 30046514 )
2018
36
Immunopathogenesis of Human Sporotrichosis: What We Already Know. ( 30065160 )
2018
37
Ecological Determinants of Sporotrichosis Etiological Agents. ( 30103554 )
2018
38
Immunity and Treatment of Sporotrichosis. ( 30127270 )
2018
39
Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America. ( 30186711 )
2018
40
Human sporotrichosis: A zoonotic outbreak in southern Brazil, 2012-2017. ( 30265327 )
2018
41
Special Issue "Sporothrix and Sporotrichosis". ( 30321990 )
2018
42
Extracellular Vesicles From Sporothrix brasiliensis Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental Sporotrichosis. ( 30333803 )
2018
43
The Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru. ( 30361425 )
2018
44
Closing the Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru. ( 30361426 )
2018
45
Report of 73 cases of cutaneous sporotrichosis in Mexico. ( 30484544 )
2018
46
Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. ( 30500849 )
2018
47
Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient. ( 30519169 )
2018
48
CARD9 variants in Chinese patients with sporotrichosis. ( 30537277 )
2018
49
Cryosurgery for the treatment of cutaneous sporotrichosis: experience with 199 cases. ( 30560992 )
2018
50
Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982-2012). ( 30594269 )
2018

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 BTNL2 CD40LG CD79A

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell proliferation GO:0042102 9.32 BTNL2 CD40LG
2 interleukin-12-mediated signaling pathway GO:0035722 9.26 IFNG IL10
3 positive regulation of interleukin-12 production GO:0032735 9.16 CD40LG IFNG
4 B cell differentiation GO:0030183 9.13 CD40LG CD79A IL10
5 B cell proliferation GO:0042100 8.8 CD40LG CD79A IL10

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 CD40LG IFNG IL10

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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