MCID: SPR010
MIFTS: 50

Sporotrichosis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 76 53 59 3 44 15 73
Rose Gardener's Disease 53

Characteristics:

Orphanet epidemiological data:

59
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD10 33 B42 B42.9
ICD9CM 35 117.1
MeSH 44 D013174
Orphanet 59 ORPHA826
MESH via Orphanet 45 D013174
UMLS via Orphanet 74 C0038034
ICD10 via Orphanet 34 B42.0 B42.1 B42.7 more
UMLS 73 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to secondary syphilis and lepromatous leprosy. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

Wikipedia : 76 Sporotrichosis (also known as \"rose gardener\'s disease\") is a disease caused by the infection of the... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 304)
# Related Disease Score Top Affiliating Genes
1 secondary syphilis 30.4 CD40LG CD79A
2 lepromatous leprosy 30.3 IFNG IL10
3 syphilis 30.2 CD40LG CD79A
4 meningitis 30.1 CD40LG IFNG IL10
5 erythema multiforme 29.9 CD79A IFNG
6 candidiasis 29.5 CD79A IFNG IL10
7 acquired immunodeficiency syndrome 29.1 CD40LG CD79A IFNG IL10
8 rheumatoid arthritis 28.7 CD40LG CD79A IFNG IL10
9 acute dacryocystitis 28.4 CALM1 CALM2 CALM3
10 ross river fever 10.7 CD40LG IL10
11 necrotizing ulcerative gingivitis 10.7 CD40LG IL10
12 hyperlucent lung 10.6 IFNG IL10
13 baylisascariasis 10.6 IFNG IL10
14 cystic echinococcosis 10.6 CD40LG IL10
15 pericardial tuberculosis 10.6 IFNG IL10
16 tuberculoid leprosy 10.6 IFNG IL10
17 african tick-bite fever 10.6 CD40LG IFNG
18 cat-scratch disease 10.6 CD40LG IFNG
19 chronic active epstein-barr virus infection 10.6 IFNG IL10
20 multicentric castleman disease 10.6 IFNG IL10
21 fascioliasis 10.6 IFNG IL10
22 panuveitis 10.6 CD40LG IL10
23 scrub typhus 10.6 CD40LG IL10
24 poliomyelitis 10.6 IFNG IL10
25 hand, foot and mouth disease 10.5 IFNG IL10
26 intermediate uveitis 10.5 IFNG IL10
27 peanut allergy 10.5 IFNG IL10
28 eales disease 10.5 IFNG IL10
29 cow milk allergy 10.5 CD79A IL10
30 selective igg deficiency disease 10.5 CD40LG CD79A
31 c1q nephropathy 10.5 CD40LG CD79A
32 meningovascular neurosyphilis 10.5 CD40LG CD79A
33 spotted fever 10.5 IFNG IL10
34 alpha chain disease 10.5 CD40LG CD79A
35 brill-zinsser disease 10.5 CD40LG CD79A
36 exudative glomerulonephritis 10.5 CD40LG CD79A
37 cork-handlers' disease 10.5 CD40LG CD79A
38 salpingo-oophoritis 10.5 CD40LG CD79A
39 hematopoietic stem cell transplantation 10.5 IFNG IL10
40 early yaws 10.5 CD40LG CD79A
41 ventilation pneumonitis 10.5 CD40LG CD79A
42 chronic interstitial cystitis 10.5 CD40LG CD79A
43 axillary adenitis 10.5 CD40LG CD79A
44 cryofibrinogenemia 10.5 CD40LG CD79A
45 trichostrongyloidiasis 10.5 CD40LG CD79A
46 subacute bacterial endocarditis 10.5 CD40LG CD79A
47 heterophyiasis 10.5 CD40LG CD79A
48 immunoglobulin g deficiency 10.5 CD40LG CD79A
49 orbital granuloma 10.5 CD40LG CD79A
50 transient hypogammaglobulinemia of infancy 10.5 CD40LG CD79A

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Antifungal Agents Phase 2,Phase 1
5 Anti-Infective Agents Phase 2,Phase 1
6 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
7 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
8 Hormone Antagonists Phase 2,Phase 1
9 Hormones Phase 2,Phase 1
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
11 Steroid Synthesis Inhibitors Phase 2,Phase 1
12 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
13
Hydroxyitraconazole Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

41
Skin, Bone, Lung, Brain, Testes, Liver, T Cells

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 625)
# Title Authors Year
1
Sporotrichosis by<i>Sporothrix schenckii</i>senso stricto with itraconazole resistance and terbinafine sensitivity observed<i>in vitro</i>and<i>in vivo</i>: Case report. ( 29204336 )
2018
2
Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia. ( 29903814 )
2018
3
Endophthalmitis in patients co-infected by HIV and sporotrichosis: a systematic review of published case reports. ( 29880916 )
2018
4
Sporotrichosis: From KOH to Molecular Biology. ( 29882883 )
2018
5
Case of pyoderma gangrenosum-like sporotrichosis caused by Sporothrix globosa in a patient with ulcerative colitis. ( 29488248 )
2018
6
Sporotrichin Skin Test for the Diagnosis of Sporotrichosis. ( 29747377 )
2018
7
Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women. ( 29684015 )
2018
8
Successful treatment outcome with itraconazole and potassium iodide in disseminated sporotrichosis. ( 29210361 )
2018
9
Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats. ( 29729723 )
2018
10
Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. ( 29538731 )
2018
11
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. ( 29899416 )
2018
12
Image Gallery: Facial sporotrichosis. ( 29668090 )
2018
13
Refractory feline sporotrichosis treated with itraconazole combined with potassium iodide. ( 29708594 )
2018
14
An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis. ( 29520092 )
2018
15
A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis. ( 29952302 )
2018
16
Dermoscopy in disseminated sporotrichosis. ( 29953691 )
2018
17
Sporotrichosis in the nail-An unusual location and presentation. ( 29387746 )
2018
18
Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. ( 29412358 )
2018
19
The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy. ( 29559998 )
2018
20
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis. ( 29440688 )
2018
21
Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review. ( 29222709 )
2017
22
The Current Status of Feline Sporotrichosis in Malaysia. ( 28855477 )
2017
23
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. ( 29166494 )
2017
24
Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. ( 28846164 )
2017
25
Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model. ( 29087533 )
2017
26
Cutaneous disseminated sporotrichosis: clinical experience of 24 cases. ( 28833587 )
2017
27
Disseminated Sporotrichosis with Osteolytic Bone Involvement. ( 28349410 )
2017
28
Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. ( 28103311 )
2017
29
Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count. ( 29147593 )
2017
30
Disseminated cutaneous sporotrichosis in patient with alcoholism. ( 29340472 )
2017
31
Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease. ( 29371525 )
2017
32
Chromoblastomycosis and sporotrichosis, two endemic but neglected fungal infections in Madagascar. ( 28847419 )
2017
33
Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis. ( 28492800 )
2017
34
Efficacy of a poly-aggregated formulation of amphotericin B in treating systemic sporotrichosis caused by Sporothrix brasiliensis. ( 28575449 )
2017
35
Disseminated cutaneous sporotrichosis presenting as a necrotic facial mass: Case and review. ( 29469701 )
2017
36
Lymphocutaneous Sporotrichosis Treated with Potassium Iodide with Development of Subclinical Hypothyroidism: Wolff-Chaikoff Effect? ( 29204393 )
2017
37
Sporotrichosis in a liver transplant patient: A case report and literature review. ( 28702316 )
2017
38
Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis. ( 29033815 )
2017
39
Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas. ( 29260114 )
2017
40
Sporotrichosis masquerading as pyoderma gangrenosum. ( 28627095 )
2017
41
Painful linear ulcers: A case of cutaneous sporotrichosis mimicking pyoderma gangrenosum. ( 29264381 )
2017
42
Cavitary Pulmonary Sporotrichosis: Case Report and Literature Review. ( 29058171 )
2017
43
Sporotrichosis among children of a hyperendemic area in Peru: an 8-year retrospective study. ( 28488313 )
2017
44
Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). ( 29080316 )
2017
45
Sporotrichosis-Associated Hospitalizations, United States, 2000-2013. ( 27648881 )
2016
46
Disseminated sporotrichosis in an immunocompetent patient. ( 27583270 )
2016
47
Atypical Cutaneous Sporotrichosis in an Immunocompetent Adult: Response to Potassium Iodide. ( 27057047 )
2016
48
Sporotrichosis: long-term treatment and follow-up in a diabetic patient from Southern Italy. ( 27595209 )
2016
49
Epidemiological investigation of an outbreak of cutaneous sporotrichosis, Northern Territory, Australia. ( 26758905 )
2016
50
Is epidemic of sporotrichosis in Abancay, Peru, caused by zoonotic transmission of Sporothrix? ( 27746089 )
2016

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CALM1 CALM2 CALM3 CD40LG CD79A IFNG
2
Show member pathways
13.62 CALM1 CALM2 CALM3 CD40LG IFNG IL10
3
Show member pathways
13.52 CALM1 CALM2 CALM3 CD40LG IFNG IL10
4
Show member pathways
13.32 CALM1 CALM2 CALM3 CD40LG CD79A
5
Show member pathways
13.21 CALM1 CALM2 CALM3 CD40LG IFNG IL10
6
Show member pathways
12.95 CALM1 CALM2 CALM3 CD79A
7
Show member pathways
12.81 CALM1 CALM2 CALM3 CD40LG CD79A
8 12.74 CALM1 CALM2 CALM3 IFNG
9
Show member pathways
12.68 CALM1 CALM2 CALM3 CD79A IFNG
10
Show member pathways
12.65 CALM1 CALM2 CALM3 CD79A
11
Show member pathways
12.62 CALM1 CALM2 CALM3 CD40LG
12
Show member pathways
12.52 CALM1 CALM2 CALM3 CD79A
13
Show member pathways
12.51 CALM1 CALM2 CALM3 CD79A
14 12.49 CD40LG CD79A IFNG IL10
15
Show member pathways
12.47 CALM1 CALM2 CALM3
16
Show member pathways
12.47 CALM1 CALM2 CALM3
17
Show member pathways
12.47 CALM1 CALM2 CALM3 CD40LG IFNG IL10
18
Show member pathways
12.45 CALM1 CALM2 CALM3
19
Show member pathways
12.45 CALM1 CALM2 CALM3
20
Show member pathways
12.44 CALM1 CALM2 CALM3
21
Show member pathways
12.44 CALM1 CALM2 CALM3 IFNG
22
Show member pathways
12.41 CALM1 CALM2 CALM3
23
Show member pathways
12.36 CALM1 CALM2 CALM3
24
Show member pathways
12.35 CALM1 CALM2 CALM3
25
Show member pathways
12.34 CALM1 CALM2 CALM3
26
Show member pathways
12.34 CALM1 CALM2 CALM3
27
Show member pathways
12.32 CALM1 CALM2 CALM3
28
Show member pathways
12.32 CALM1 CALM2 CALM3 CD40LG
29
Show member pathways
12.31 CALM1 CALM2 CALM3 CD79A
30 12.29 CALM1 CALM2 CALM3
31
Show member pathways
12.28 CALM1 CALM2 CALM3
32
Show member pathways
12.27 CALM1 CALM2 CALM3
33
Show member pathways
12.26 CALM1 CALM2 CALM3
34
Show member pathways
12.26 CALM1 CALM2 CALM3
35
Show member pathways
12.25 CALM1 CALM2 CALM3
36
Show member pathways
12.23 CALM1 CALM2 CALM3
37
Show member pathways
12.19 CALM1 CALM2 CALM3
38
Show member pathways
12.19 CD40LG IFNG IL10
39
Show member pathways
12.18 CALM1 CALM2 CALM3
40
Show member pathways
12.18 CALM1 CALM2 CALM3
41
Show member pathways
12.17 CALM1 CALM2 CALM3 IFNG
42
Show member pathways
12.15 CALM1 CALM2 CALM3
43
Show member pathways
12.13 CALM1 CALM2 CALM3
44
Show member pathways
12.13 CALM1 CALM2 CD40LG IFNG IL10
45
Show member pathways
12.12 CALM1 CALM2 CALM3
46
Show member pathways
12.12 CALM1 CALM2 CALM3 IL10
47
Show member pathways
12.11 CALM1 CALM2 CALM3
48 12.11 CALM1 CALM2 CALM3
49
Show member pathways
12.09 CALM1 CALM2 CALM3
50
Show member pathways
12.06 CALM1 CALM2 CALM3

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.58 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.54 CALM1 CALM2 CALM3
3 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
4 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
5 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
6 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
7 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 9.78 CD40LG CD79A IL10
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 substantia nigra development GO:0021762 9.77 CALM1 CALM2 CALM3
4 regulation of cytokinesis GO:0032465 9.76 CALM1 CALM2 CALM3
5 regulation of heart rate GO:0002027 9.75 CALM1 CALM2 CALM3
6 B cell proliferation GO:0042100 9.74 CD40LG CD79A IL10
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.73 CALM1 CALM2 CALM3
8 positive regulation of protein autophosphorylation GO:0031954 9.72 CALM1 CALM2 CALM3
9 positive regulation of protein dephosphorylation GO:0035307 9.71 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.7 CALM1 CALM2 CALM3
11 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.69 CALM1 CALM2 CALM3
12 regulation of cardiac muscle contraction GO:0055117 9.67 CALM1 CALM2 CALM3
13 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.65 CALM1 CALM2 CALM3
14 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
15 interleukin-12-mediated signaling pathway GO:0035722 9.62 IFNG IL10
16 positive regulation of interleukin-12 production GO:0032735 9.61 CD40LG IFNG
17 obsolete positive regulation of cAMP biosynthetic process GO:0030819 9.61 CALM1 CALM2 CALM3
18 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
19 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
20 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.5 CALM1 CALM2 CALM3
21 positive regulation of protein serine/threonine kinase activity GO:0071902 9.46 CALM1 CALM2 CALM3 IFNG
22 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
23 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
24 positive regulation of cyclic nucleotide metabolic process GO:0030801 8.8 CALM1 CALM2 CALM3

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.65 CALM1 CALM2 CALM3
2 cytokine activity GO:0005125 9.63 CD40LG IFNG IL10
3 ion channel binding GO:0044325 9.58 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.54 CALM1 CALM2 CALM3
5 protein serine/threonine kinase activator activity GO:0043539 9.5 CALM1 CALM2 CALM3
6 calcium channel inhibitor activity GO:0019855 9.43 CALM1 CALM2
7 titin binding GO:0031432 9.43 CALM1 CALM2 CALM3
8 adenylate cyclase binding GO:0008179 9.33 CALM1 CALM2 CALM3
9 protein phosphatase activator activity GO:0072542 9.13 CALM1 CALM2 CALM3
10 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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