MCID: SPR010
MIFTS: 50

Sporotrichosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 76 53 59 3 44 15 73
Rose Gardener's Disease 53

Characteristics:

Orphanet epidemiological data:

59
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD10 33 B42 B42.9
ICD9CM 35 117.1
MeSH 44 D013174
SNOMED-CT 68 42094007
Orphanet 59 ORPHA826
MESH via Orphanet 45 D013174
UMLS via Orphanet 74 C0038034
ICD10 via Orphanet 34 B42.0 B42.1 B42.7 more
UMLS 73 C0038034

Summaries for Sporotrichosis

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in_formation_of red papule at the site of inoculation.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to lepromatous leprosy and syphilis. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and lung.

Wikipedia : 76 Sporotrichosis (also known as "rose gardener''s disease") is a disease caused by the infection of the... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 lepromatous leprosy 30.1 IFNG IL10
2 syphilis 30.0 CD40LG CD79A
3 secondary syphilis 30.0 CD40LG CD79A
4 human immunodeficiency virus infectious disease 30.0 IFNG IL10
5 viral infectious disease 29.7 CD40LG IFNG IL10
6 acute dacryocystitis 29.3 CALM1 CALM2 CALM3
7 arthritis 10.2
8 pyoderma 10.2
9 pyoderma gangrenosum 10.2
10 cephalosporin allergy 10.2 IFNG IL10
11 hyperlucent lung 10.2 IFNG IL10
12 nickel allergic contact dermatitis 10.2 IFNG IL10
13 allergic contact dermatitis 10.2 IFNG IL10
14 baylisascariasis 10.2 IFNG IL10
15 penicillin allergy 10.2 IFNG IL10
16 pericardial tuberculosis 10.2 IFNG IL10
17 tuberculoid leprosy 10.2 IFNG IL10
18 fungal meningitis 10.2 IFNG IL10
19 chronic active epstein-barr virus infection 10.2 IFNG IL10
20 peanut allergy 10.2 IFNG IL10
21 fascioliasis 10.2 IFNG IL10
22 intermediate uveitis 10.2 IFNG IL10
23 hand, foot and mouth disease 10.2 IFNG IL10
24 mycoplasma pneumoniae pneumonia 10.2 IFNG IL10
25 poliomyelitis 10.2 IFNG IL10
26 eales disease 10.2 IFNG IL10
27 spotted fever 10.2 IFNG IL10
28 coccidiosis 10.2 IFNG IL10
29 hematopoietic stem cell transplantation 10.2 IFNG IL10
30 aseptic meningitis 10.2 IFNG IL10
31 primary peritoneal carcinoma 10.2 IFNG IL10
32 plasmodium vivax malaria 10.2 IFNG IL10
33 polyradiculoneuropathy 10.2 IFNG IL10
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2 IFNG IL10
35 extrapulmonary tuberculosis 10.2 IFNG IL10
36 paranasal sinus disease 10.2 IFNG IL10
37 african tick-bite fever 10.2 CD40LG IFNG
38 q fever 10.2 IFNG IL10
39 chromoblastomycosis 10.2
40 leishmaniasis 10.2
41 acute graft versus host disease 10.2 IFNG IL10
42 autoimmune uveitis 10.1 IFNG IL10
43 cow milk allergy 10.1 CD79A IL10
44 milk allergy 10.1 CD79A IL10
45 paracoccidioidomycosis 10.1 IFNG IL10
46 transient hypogammaglobulinemia of infancy 10.1 CD40LG IL10
47 opportunistic mycosis 10.1 IFNG IL10
48 testicular disease 10.1 IFNG IL10
49 mixed connective tissue disease 10.1 IFNG IL10
50 idiopathic neutropenia 10.1 CD40LG IL10

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Anti-Infective Agents Phase 2,Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1
6 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1
7 Hormone Antagonists Phase 2,Phase 1
8 Hormones Phase 2,Phase 1
9 Antifungal Agents Phase 2,Phase 1
10 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
12 Steroid Synthesis Inhibitors Phase 2,Phase 1
13
Hydroxyitraconazole Phase 1, Phase 2
14 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

41
Skin, Bone, Lung, Brain, Testes, Liver, T Cells

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 949)
# Title Authors Year
1
Sporotrichosis by<i>Sporothrix schenckii</i>senso stricto with itraconazole resistance and terbinafine sensitivity observed<i>in vitro</i>and<i>in vivo</i>: Case report. ( 29204336 )
2018
2
Draft Genome Sequences of Two Sporothrix schenckii Clinical Isolates Associated with Human Sporotrichosis in Colombia. ( 29903814 )
2018
3
Endophthalmitis in patients co-infected by HIV and sporotrichosis: a systematic review of published case reports. ( 29880916 )
2018
4
Sporotrichosis: From KOH to Molecular Biology. ( 29882883 )
2018
5
Case of pyoderma gangrenosum-like sporotrichosis caused by Sporothrix globosa in a patient with ulcerative colitis. ( 29488248 )
2018
6
Sporotrichin Skin Test for the Diagnosis of Sporotrichosis. ( 29747377 )
2018
7
Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women. ( 29684015 )
2018
8
Successful treatment outcome with itraconazole and potassium iodide in disseminated sporotrichosis. ( 29210361 )
2018
9
Comparison of the Sensitivity of Three Methods for the Early Diagnosis of Sporotrichosis in Cats. ( 29729723 )
2018
10
Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. ( 29538731 )
2018
11
Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. ( 29899416 )
2018
12
The role of dermoscopy in the diagnosis of deep mycoses and systemic mycoses with cutaneous involvement Comment on &amp;quot;Dermoscopy in disseminated sporotrichosis&amp;quot;. ( 29953679 )
2018
13
Image Gallery: Facial sporotrichosis. ( 29668090 )
2018
14
Refractory feline sporotrichosis treated with itraconazole combined with potassium iodide. ( 29708594 )
2018
15
An immunoproteomic approach revealing peptides from Sporothrix brasiliensis that induce a cellular immune response in subcutaneous sporotrichosis. ( 29520092 )
2018
16
A randomized comparison of combined itraconazole and Nd:YAG 1064-nm laser vs itraconazole alone for the treatment of cutaneous sporotrichosis. ( 29952302 )
2018
17
Dermoscopy in disseminated sporotrichosis. ( 29953691 )
2018
18
Sporotrichosis in the nail-An unusual location and presentation. ( 29387746 )
2018
19
Feline sporotrichosis: associations between clinical-epidemiological profiles and phenotypic-genotypic characteristics of the etiological agents in the Rio de Janeiro epizootic area. ( 29412358 )
2018
20
The Infection Returns: A Case of Pulmonary Sporotrichosis Relapse after Chemotherapy. ( 29559998 )
2018
21
Unbalanced inflammatory reaction could increase tissue destruction and worsen skin infectious diseases - a comparative study of leishmaniasis and sporotrichosis. ( 29440688 )
2018
22
Zoonotic Sporotrichosis Related to Cat Contact: First Case Report from Panama in Central America. ( 30186711 )
2018
23
Human sporotrichosis: A zoonotic outbreak in southern Brazil, 2012-2017. ( 30265327 )
2018
24
Special Issue "Sporothrix and Sporotrichosis". ( 30321990 )
2018
25
Extracellular Vesicles From Sporothrix brasiliensis Are an Important Virulence Factor That Induce an Increase in Fungal Burden in Experimental Sporotrichosis. ( 30333803 )
2018
26
The Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru. ( 30361425 )
2018
27
Closing the Brief Case: Cutaneous Sporotrichosis in an Immunocompetent Patient after Travel to Peru. ( 30361426 )
2018
28
Report of 73 cases of cutaneous sporotrichosis in Mexico. ( 30484544 )
2018
29
Co-infection with feline retrovirus is related to changes in immunological parameters of cats with sporotrichosis. ( 30500849 )
2018
30
Atypical Manifestation of Disseminated Sporotrichosis in an AIDS Patient. ( 30519169 )
2018
31
Facial Cutaneous Sporotrichosis in a Boy. ( 30527560 )
2018
32
CARD9 variants in Chinese patients with sporotrichosis. ( 30537277 )
2018
33
Sporotrichosis transmitted by a cockatiel (Nymphicus hollandicus). ( 29080316 )
2018
34
Primary conjunctival sporotrichosis: An atypical presentation of the disease. ( 29984295 )
2018
35
Sporotrichosis in Southern Brazil, towards an epidemic? ( 30009528 )
2018
36
A case of disseminated sporotrichosis caused by Sporothrix brasiliensis. ( 30046514 )
2018
37
Immunopathogenesis of Human Sporotrichosis: What We Already Know. ( 30065160 )
2018
38
Ecological Determinants of Sporotrichosis Etiological Agents. ( 30103554 )
2018
39
Immunity and Treatment of Sporotrichosis. ( 30127270 )
2018
40
Successful Treatment of Canine Sporotrichosis with Terbinafine: Case Reports and Literature Review. ( 29222709 )
2017
41
The Current Status of Feline Sporotrichosis in Malaysia. ( 28855477 )
2017
42
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics. ( 29166494 )
2017
43
Cutaneous sporotrichosis treated with methylene blue-daylight photodynamic therapy. ( 28846164 )
2017
44
Experimental sporotrichosis in a cyclophosphamide-induced immunosuppressed mice model. ( 29087533 )
2017
45
Cutaneous disseminated sporotrichosis: clinical experience of 24 cases. ( 28833587 )
2017
46
Disseminated Sporotrichosis with Osteolytic Bone Involvement. ( 28349410 )
2017
47
Zoonotic Epidemic of Sporotrichosis: Cat to Human Transmission. ( 28103311 )
2017
48
Rapidly Progressive Disseminated Sporotrichosis as the First Presentation of HIV Infection in a Patient with a Very Low CD4 Cell Count. ( 29147593 )
2017
49
Disseminated cutaneous sporotrichosis in patient with alcoholism. ( 29340472 )
2017
50
Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease. ( 29371525 )
2017

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 CALM1 CALM2 CALM3 CD40LG CD79A IFNG
2
Show member pathways
13.62 CALM1 CALM2 CALM3 CD40LG IFNG IL10
3
Show member pathways
13.52 CALM1 CALM2 CALM3 CD40LG IFNG IL10
4
Show member pathways
13.4 CALM1 CALM2 CALM3 IFNG IL10
5
Show member pathways
13.32 CALM1 CALM2 CALM3 CD40LG CD79A
6
Show member pathways
13.2 CALM1 CALM2 CALM3 CD40LG IFNG IL10
7
Show member pathways
13.09 CALM1 CALM2 CALM3 CD79A IFNG
8
Show member pathways
12.96 CALM1 CALM2 CALM3 CD79A
9
Show member pathways
12.8 CALM1 CALM2 CALM3 CD40LG CD79A
10 12.75 CALM1 CALM2 CALM3 IFNG
11
Show member pathways
12.65 CALM1 CALM2 CALM3 CD79A
12
Show member pathways
12.62 CALM1 CALM2 CALM3 CD40LG
13
Show member pathways
12.54 CALM1 CALM2 CALM3 CD40LG
14
Show member pathways
12.54 CALM1 CALM2 CALM3 CD40LG IFNG IL10
15
Show member pathways
12.51 CALM1 CALM2 CALM3 CD79A
16 12.49 CD40LG CD79A IFNG IL10
17
Show member pathways
12.48 CALM1 CALM2 CALM3
18
Show member pathways
12.46 CALM1 CALM2 CALM3
19
Show member pathways
12.45 CALM1 CALM2 CALM3
20
Show member pathways
12.45 CALM1 CALM2 CALM3
21
Show member pathways
12.44 CALM1 CALM2 CALM3 IFNG
22
Show member pathways
12.42 CALM1 CALM2 CALM3
23
Show member pathways
12.37 CALM1 CALM2 CALM3
24
Show member pathways
12.36 CALM1 CALM2 CALM3
25
Show member pathways
12.35 CALM1 CALM2 CALM3
26
Show member pathways
12.34 CALM1 CALM2 CALM3
27
Show member pathways
12.34 CALM1 CALM2 CALM3
28
Show member pathways
12.33 CALM1 CALM2 CALM3
29
Show member pathways
12.31 CALM1 CALM2 CALM3 CD40LG
30
Show member pathways
12.3 CALM1 CALM2 CALM3 CD79A
31 12.29 CALM1 CALM2 CALM3
32
Show member pathways
12.29 CALM1 CALM2 CALM3
33
Show member pathways
12.28 CALM1 CALM2 CALM3
34
Show member pathways
12.26 CALM1 CALM2 CALM3
35
Show member pathways
12.26 CALM1 CALM2 CALM3
36
Show member pathways
12.26 CALM1 CALM2 CALM3
37
Show member pathways
12.24 CALM1 CALM2 CALM3 IFNG
38
Show member pathways
12.23 CALM1 CALM2 CALM3
39
Show member pathways
12.2 CALM1 CALM2 CALM3
40
Show member pathways
12.2 CALM1 CALM2 CALM3
41
Show member pathways
12.2 CD40LG IFNG IL10
42
Show member pathways
12.18 CALM1 CALM2 CALM3
43
Show member pathways
12.17 CALM1 CALM2 CD40LG IFNG IL10
44
Show member pathways
12.15 CALM1 CALM2 CALM3
45
Show member pathways
12.13 CALM1 CALM2 CALM3
46
Show member pathways
12.13 CALM1 CALM2 CALM3
47
Show member pathways
12.12 CALM1 CALM2 CALM3
48
Show member pathways
12.12 CALM1 CALM2 CALM3 IL10
49 12.11 CALM1 CALM2 CALM3
50
Show member pathways
12.1 CALM1 CALM2 CALM3

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.83 CALM1 CALM2 CALM3 CD40LG IFNG
2 spindle GO:0005819 9.63 CALM1 CALM2 CALM3
3 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
4 myelin sheath GO:0043209 9.54 CALM1 CALM2 CALM3
5 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
6 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
7 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
8 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
9 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.79 CALM1 CALM2 CALM3
2 B cell differentiation GO:0030183 9.78 CD40LG CD79A IL10
3 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.77 CALM1 CALM2 CALM3
5 regulation of cytokinesis GO:0032465 9.76 CALM1 CALM2 CALM3
6 B cell proliferation GO:0042100 9.74 CD40LG CD79A IL10
7 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
8 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.72 CALM1 CALM2 CALM3
9 positive regulation of protein dephosphorylation GO:0035307 9.71 CALM1 CALM2 CALM3
10 positive regulation of protein autophosphorylation GO:0031954 9.7 CALM1 CALM2 CALM3
11 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.69 CALM1 CALM2 CALM3
12 regulation of synaptic vesicle exocytosis GO:2000300 9.67 CALM1 CALM3
13 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 CALM1 CALM2 CALM3
14 interleukin-12-mediated signaling pathway GO:0035722 9.66 IFNG IL10
15 response to amphetamine GO:0001975 9.66 CALM1 CALM3
16 activation of adenylate cyclase activity GO:0007190 9.65 CALM1 CALM3
17 positive regulation of DNA binding GO:0043388 9.65 CALM2 CALM3
18 positive regulation of interleukin-12 production GO:0032735 9.65 CD40LG IFNG
19 regulation of cardiac muscle contraction GO:0055117 9.65 CALM1 CALM2 CALM3
20 positive regulation of nitric-oxide synthase activity GO:0051000 9.64 CALM1 CALM3
21 response to corticosterone GO:0051412 9.64 CALM1 CALM3
22 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.63 CALM1 CALM3
23 regulation of synaptic vesicle endocytosis GO:1900242 9.63 CALM1 CALM3
24 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.63 CALM1 CALM2 CALM3
25 establishment of protein localization to membrane GO:0090150 9.62 CALM1 CALM3
26 regulation of high voltage-gated calcium channel activity GO:1901841 9.62 CALM1 CALM3
27 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.61 CALM1 CALM2 CALM3
28 establishment of protein localization to mitochondrial membrane GO:0090151 9.58 CALM1 CALM3
29 detection of calcium ion GO:0005513 9.58 CALM1 CALM2 CALM3
30 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.54 CALM1 CALM2 CALM3
31 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.5 CALM1 CALM2 CALM3
32 positive regulation of protein serine/threonine kinase activity GO:0071902 9.46 CALM1 CALM2 CALM3 IFNG
33 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.43 CALM1 CALM2 CALM3
34 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
35 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.73 CALM1 CALM2 CALM3
2 cytokine activity GO:0005125 9.71 CD40LG IFNG IL10
3 ion channel binding GO:0044325 9.65 CALM1 CALM2 CALM3
4 disordered domain specific binding GO:0097718 9.58 CALM1 CALM2 CALM3
5 enzyme regulator activity GO:0030234 9.55 CALM1 CALM3
6 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
7 phosphatidylinositol 3-kinase binding GO:0043548 9.52 CALM1 CALM3
8 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
9 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
10 calcium channel inhibitor activity GO:0019855 9.49 CALM1 CALM2
11 nitric-oxide synthase regulator activity GO:0030235 9.46 CALM1 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.43 CALM1 CALM3
13 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
14 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
15 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
16 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....