MCID: SPR010
MIFTS: 48

Sporotrichosis

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Sporotrichosis

MalaCards integrated aliases for Sporotrichosis:

Name: Sporotrichosis 12 74 52 58 3 43 15 17 71 32
Rose Gardener's Disease 52

Characteristics:

Orphanet epidemiological data:

58
sporotrichosis
Inheritance: Not applicable; Prevalence: >1/1000 (Mexico),1-5/10000 (Peru); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14484
ICD9CM 34 117.1
MeSH 43 D013174
SNOMED-CT 67 42094007
ICD10 32 B42 B42.9
MESH via Orphanet 44 D013174
ICD10 via Orphanet 33 B42.0 B42.1 B42.7 more
UMLS via Orphanet 72 C0038034
Orphanet 58 ORPHA826
UMLS 71 C0038034

Summaries for Sporotrichosis

CDC : 3 Sporotrichosis (also known as "rose gardener's disease") is an infection caused by a fungus called Sporothrix. This fungus lives throughout the world in soil and on plant matter such as sphagnum moss, rose bushes, and hay.1,2 People get sporotrichosis by coming in contact with the fungal spores in the environment. Cutaneous (skin) infection is the most common form of the infection. It occurs when the fungus enters the skin through a small cut or scrape, usually after someone touches contaminated plant matter. Skin on the hands or arms is most commonly affected.

MalaCards based summary : Sporotrichosis, also known as rose gardener's disease, is related to subcutaneous mycosis and chromoblastomycosis. An important gene associated with Sporotrichosis is IL10 (Interleukin 10), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and bone, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Disease Ontology : 12 A primary systemic mycosis that results in a systemic fungal infection, has material basis in Sporothrix schenckii in animals and humans and results in formation of red papule at the site of inoculation.

Wikipedia : 74 Sporotrichosis is a disease caused by the infection of the fungus Sporothrix schenckii. This fungal... more...

Related Diseases for Sporotrichosis

Diseases related to Sporotrichosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 522)
# Related Disease Score Top Affiliating Genes
1 subcutaneous mycosis 30.7 EMB CLEC7A CBSL CARD9
2 chromoblastomycosis 30.7 CLEC7A CBSL CARD9
3 cutaneous leishmaniasis 30.3 TNF IL10 IFNG
4 syphilis 30.3 CD79A CD40LG CD4
5 conjunctivitis 30.2 TNF IL10 IFNG
6 secondary syphilis 30.1 CD79A CD40LG CD4
7 osteomyelitis 30.1 TNF IL10 IFNG
8 cat-scratch disease 30.0 CD40LG CD4
9 paracoccidioidomycosis 30.0 TNF IL10 IFNG CD40LG
10 tuberculoid leprosy 30.0 IL10 IFNG CD4
11 esophageal candidiasis 29.9 CD4 CARD9
12 pulmonary tuberculosis 29.9 TNF IL10 IFNG
13 nocardiosis 29.9 TNF CD4
14 pleural empyema 29.9 CD79A CD40LG CD4
15 multifocal choroiditis 29.9 TNF IL10
16 tenosynovitis 29.9 TNF CD40LG
17 phaeohyphomycosis 29.9 CLEC7A CBSL CARD9
18 lepromatous leprosy 29.8 TNF IL10 IFNG
19 coccidioidomycosis 29.8 CLEC7A CD40LG CD4 CARD9
20 soft tissue sarcoma 29.8 TNF IFNG
21 lung disease 29.8 TNF IL10 IFNG CD40LG
22 mucormycosis 29.7 IFNG CLEC7A CD4 CARD9
23 oral candidiasis 29.7 CLEC7A CD4 CARD9
24 chronic meningitis 29.6 CD40LG CD4
25 sarcoidosis 1 29.6 TNF IFNG CD40LG CD4
26 spondylitis 29.6 TNF IL10 IFNG
27 lupus erythematosus 29.6 TNF IL10 IFNG CD40LG
28 toxic shock syndrome 29.6 TNF IL10 IFNG CD40LG
29 diarrhea 29.5 TNF IL10 IFNG CD40LG
30 human immunodeficiency virus type 1 29.5 TNF IL10 IFNG CD4
31 endophthalmitis 29.5 TNF CD4 CARD9
32 skin sarcoidosis 29.5 TNF CD4
33 peritonitis 29.5 TNF IL10 IFNG
34 cellulitis 29.4 TNF IL10 CD40LG CD4
35 meningitis 29.4 TNF IL10 IFNG CD40LG
36 rheumatic disease 29.3 TNF IL10 IFNG CD40LG
37 lymphadenitis 29.3 TNF IL10 IFNG CD4
38 exanthem 29.3 TNF IL10 CD40LG CD4
39 diphtheria 29.3 TNF ITGAX IFNG CD40LG
40 histoplasmosis 29.3 TNF IFNG CLEC7A CD40LG CD4
41 allergic hypersensitivity disease 29.2 TNF IL10 IFNG CD79A CD4
42 aspergillosis 29.2 TNF IL10 IFNG CLEC7A
43 leprosy 3 29.2 TNF IL10 IFNG CD40LG CD4
44 immune deficiency disease 29.1 TNF IL10 IFNG CD79A CD40LG CD4
45 orchitis 29.1 TNF IL10 CD40LG CD4
46 miliary tuberculosis 29.1 TNF IFNG CD40LG CD4
47 acquired immunodeficiency syndrome 29.1 TNF IL10 IFNG CD79A CD40LG CD4
48 cryptococcosis 29.0 TNF IL10 IFNG CLEC7A CD4
49 skin disease 29.0 TNF IL10 IFNG CD79A CD40LG CD4
50 candidiasis 28.9 TNF IL10 IFNG CLEC7A CD40LG CARD9

Graphical network of the top 20 diseases related to Sporotrichosis:



Diseases related to Sporotrichosis

Symptoms & Phenotypes for Sporotrichosis

MGI Mouse Phenotypes related to Sporotrichosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 CARD9 CBSL CD4 CD40LG CD79A CLEC7A
2 endocrine/exocrine gland MP:0005379 9.86 CBSL CD4 CD40LG EMB IFNG IL10
3 immune system MP:0005387 9.65 CARD9 CBSL CD4 CD40LG CD79A CLEC7A
4 no phenotypic analysis MP:0003012 9.1 CD4 CD79A IFNG IL10 ITGAX TNF

Drugs & Therapeutics for Sporotrichosis

Drugs for Sporotrichosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
3
Itraconazole Approved, Investigational Phase 1, Phase 2 84625-61-6 55283
4 Anti-Infective Agents Phase 2
5 Cytochrome P-450 Enzyme Inhibitors Phase 2
6 Hormone Antagonists Phase 2
7 Antifungal Agents Phase 2
8 Steroid Synthesis Inhibitors Phase 2
9 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
10 Hormones Phase 2
11 Cytochrome P-450 CYP3A Inhibitors Phase 1, Phase 2
12
Hydroxyitraconazole Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Study of Fluconazole for Lymphocutaneous and Visceral Sporotrichosis Completed NCT00004938 Phase 2 fluconazole
2 Phase II Pilot Study of Fluconazole for Histoplasmosis, Blastomycosis, and Sporotrichosis Completed NCT00004808 Phase 2 fluconazole
3 Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis Completed NCT00004811 Phase 1, Phase 2 itraconazole
4 Invasive Mould Infections in Indian ICUs - Descriptive Epidemiology, Management and Outcome Completed NCT02683642

Search NIH Clinical Center for Sporotrichosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Itraconazole
Potassium Iodide
POTASSIUM IODIDE GRANULES

Cochrane evidence based reviews: sporotrichosis

Genetic Tests for Sporotrichosis

Anatomical Context for Sporotrichosis

MalaCards organs/tissues related to Sporotrichosis:

40
Skin, Lung, Bone, Brain, Testes, Eye, B Cells

Publications for Sporotrichosis

Articles related to Sporotrichosis:

(show top 50) (show all 1678)
# Title Authors PMID Year
1
Investigation of a Microemulsion Containing Clotrimazole and Itraconazole for Transdermal Delivery for the Treatment of Sporotrichosis. 61
31604084 2020
2
Arm Sporotrichosis Secondary to Scratching Finger Verruca Vulgaris. 61
31974751 2020
3
Electrosurgery as Adjuvant Therapy for Cutaneous Sporotrichosis. 61
30664002 2020
4
Tumorous formation of the forehead. 61
31993874 2020
5
Antifungal activity of different molecular weight chitosans against planktonic cells and biofilm of Sporothrix brasiliensis. 61
31812752 2020
6
Proteomic analysis of Sporothrix schenckii cell wall reveals proteins involved in oxidative stress response induced by menadione. 61
31962184 2020
7
Development and evaluation of a real-time polymerase chain reaction for fast diagnosis of sporotrichosis caused by Sporothrix globosa. 61
30927430 2020
8
Zoonotic sporotrichosis with greater severity in Rio de Janeiro, Brazil: 118 hospitalizations and 11 deaths in the last 2 decades in a reference institution. 61
31220310 2020
9
Diagnostic value of fluorescein-labeled chitinase staining in formalin-fixed and paraffin-embedded tissues of fungal disease. 61
31329921 2020
10
Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and prospects. 61
31201931 2019
11
North American blastomycosis in an immunocompromised patient. 61
31939939 2019
12
Meningeal and multiorgan disseminated sporotrichosis: A case report and autopsy study. 61
31737471 2019
13
Epidemiological and clinical comparisons of paediatric and adult sporotrichosis in Jilin Province, China. 61
31829465 2019
14
Identification by MALDI-TOF MS of Sporothrix brasiliensis Isolated from a Subconjunctival Infiltrative Lesion in an Immunocompetent Patient. 61
31877698 2019
15
Antifungal activity of silver salts of Keggin-type heteropolyacids against Sporothrix spp. 61
31893614 2019
16
The interaction between Sporothrix schenckii sensu stricto and Sporothrix brasiliensis with Acanthamoeba castellanii. 61
31820499 2019
17
Synthesis and Identification of Pentathiepin-Based Inhibitors of Sporothrix brasiliensis. 61
31816950 2019
18
Diagnostic value of a nested polymerase chain reaction for diagnosing cutaneous sporotrichosis from paraffin-embedded skin tissue. 61
31518455 2019
19
Mannose-Binding Lectin and Mannose-Binding Lectin-Associated Serine Protease-2 Genotypes and Serum Levels in Patients with Sporotrichosis. 61
31549610 2019
20
Immunization with recombinant enolase of Sporothrix spp. (rSsEno) confers effective protection against sporotrichosis in mice. 61
31748544 2019
21
Disseminated sporotrichosis following iatrogenic immunosuppression for suspected pyoderma gangrenosum. 61
31473127 2019
22
Prevalence and antifungal susceptibility of Sporothrix species in Jiangxi, central China. 61
30657948 2019
23
Sporotrichosis in the Highlands of Madagascar, 2013-20171. 61
31538565 2019
24
Spotting sporotrichosis skin infection: The first Australian paediatric case series. 61
31613031 2019
25
Disseminated Cutaneous and Osteoarticular Sporotrichosis Mimicking Pyoderma Gangrenosum. 61
31660357 2019
26
Virulence Factors in Sporothrix schenckii, One of the Causative Agents of Sporotrichosis. 61
31589121 2019
27
Sporotrichosis caused by Sporothrix brasiliensis in Argentina: Case report, molecular identification and in vitro susceptibility pattern to antifungal drugs. 61
31732417 2019
28
In vivo protection of the marjoram (Origanum majorana Linn.) essential oil in the cutaneous sporotrichosis by Sporothrix brasiliensis. 61
31621419 2019
29
Geo-epidemiology and socioeconomic aspects of human sporotrichosis in the municipality of Duque de Caxias, Rio de Janeiro, Brazil, between 2007 and 2016. 61
31667523 2019
30
Molecular epidemiology of Sporothrix schenkii isolates in Malaysia. 61
31642485 2019
31
Effective treatment using itraconazole combined with terbinafine in the treatment of nasal sporotrichosis: A case report. 61
31517860 2019
32
A novel case of cutaneous squamous cell carcinoma at the site of previous sporotrichosis. 61
31556217 2019
33
The Diagnosis of Fungal Neglected Tropical Diseases (Fungal NTDs) and the Role of Investigation and Laboratory Tests: An Expert Consensus Report. 61
31554262 2019
34
Sporothrix humicola (Ascomycota: Ophiostomatales) - A soil-borne fungus with pathogenic potential in the eastern quoll (Dasyurus viverrinus). 61
31428554 2019
35
Application of platelet-rich plasma and platelet lysate in the treatment of experimental lymphocutaneous sporotrichosi. 61
31850390 2019
36
Ocular Sporotrichosis: 26 Cases with Bulbar Involvement in a Hyperendemic Area of Zoonotic Transmission. 61
31411512 2019
37
Localized Cutaneous Sporotrichosis on Face in Healthy Thai Female. 61
31309401 2019
38
High-Virulence Cat-Transmitted Ocular Sporotrichosis. 61
31230198 2019
39
Disseminated Sporotrichosis in a Bilby (Macrotis lagotis). 61
31375162 2019
40
Pediatric Sporotrichosis in Jilin Province of China (2010-2016): a Retrospective Study of 704 Cases. 61
31356658 2019
41
Emerging Fungal Infections: New Patients, New Patterns, and New Pathogens. 61
31330862 2019
42
Osteoarticular Sporotrichosis vs Rheumatoid Arthritis: A Tale of Two Granulomatous Arthritides. 61
30904507 2019
43
Central Nervous System Infection with Other Endemic Mycoses: Rare Manifestation of Blastomycosis, Paracoccidioidomycosis, Talaromycosis, and Sporotrichosis. 61
31323746 2019
44
In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii. 61
31171430 2019
45
Interaction with Pantoea agglomerans Modulates Growth and Melanization of Sporothrix brasiliensis and Sporothrix schenckii. 61
31214857 2019
46
Disseminated Sporotrichosis in a Liver Transplant Patient: A Case Report. 61
31155205 2019
47
Endemic Mycoses in Children. 61
31205246 2019
48
Cryosurgery for the treatment of cutaneous sporotrichosis: experience with 199 cases. 61
30560992 2019
49
CARD9 variants in Chinese patients with sporotrichosis. 61
30537277 2019
50
Development of a Method for the Quantification of Clotrimazole and Itraconazole and Study of Their Stability in a New Microemulsion for the Treatment of Sporotrichosis. 61
31242573 2019

Variations for Sporotrichosis

Expression for Sporotrichosis

Search GEO for disease gene expression data for Sporotrichosis.

Pathways for Sporotrichosis

Pathways related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TNF ITGAX IL10 IFNG CLEC7A CD79A
2
Show member pathways
13.21 TNF ITGAX IL10 IFNG CD40LG CD4
3
Show member pathways
12.71 TNF IL10 IFNG CD40LG CD4
4
Show member pathways
12.53 TNF IFNG CD40LG CD4
5
Show member pathways
12.45 TNF IL10 IFNG CD4
6
Show member pathways
12.44 TNF IL10 IFNG CD4
7
Show member pathways
12.44 TNF IL10 IFNG CD79A CD40LG CD4
8
Show member pathways
12.42 TNF IL10 IFNG CD40LG CD4
9 12.31 TNF IL10 IFNG CD79A CD40LG CARD9
10
Show member pathways
12.13 TNF IL10 IFNG CD40LG
11
Show member pathways
12.06 TNF IL10 CLEC7A CARD9
12
Show member pathways
11.87 TNF IL10 IFNG CD4
13 11.85 TNF ITGAX IL10
14 11.78 TNF IL10 IFNG
15 11.69 TNF ITGAX IL10 IFNG CLEC7A CARD9
16
Show member pathways
11.65 TNF IFNG CD40LG
17 11.64 TNF IL10 IFNG CD4
18 11.61 TNF IL10 IFNG
19
Show member pathways
11.54 TNF IFNG CD40LG
20 11.46 IL10 CD40LG CD4
21 11.42 TNF ITGAX IL10 IFNG CD4
22 11.38 IL10 IFNG CD4
23 11.37 TNF IL10 IFNG CD40LG
24 11.27 CD79A CD40LG CD4
25 11.24 TNF IL10 IFNG
26 11.16 TNF ITGAX IL10 IFNG CD79A CD4
27 11.02 TNF IL10 IFNG CD4

GO Terms for Sporotrichosis

Cellular components related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 TNF ITGAX CLEC7A CD40LG CD4
2 external side of plasma membrane GO:0009897 9.02 TNF ITGAX CD79A CD40LG CD4

Biological processes related to Sporotrichosis according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.94 TNF IL10 CLEC7A CD40LG
2 immune response GO:0006955 9.92 TNF IL10 IFNG CD40LG CD4
3 cytokine-mediated signaling pathway GO:0019221 9.88 TNF ITGAX IL10 CD4
4 B cell differentiation GO:0030183 9.73 IL10 CD79A CD40LG
5 regulation of insulin secretion GO:0050796 9.71 TNF KCNB1 IFNG
6 positive regulation of amyloid-beta formation GO:1902004 9.63 TNF IFNG
7 astrocyte activation GO:0048143 9.63 TNF IFNG
8 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.63 TNF CLEC7A CARD9
9 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 TNF IFNG
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF IL10
11 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TNF CLEC7A
12 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.61 CLEC7A CD4
13 positive regulation of phagocytosis GO:0050766 9.61 TNF IFNG CLEC7A
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.6 TNF CLEC7A
15 positive regulation of chemokine biosynthetic process GO:0045080 9.59 TNF IFNG
16 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 TNF IFNG CLEC7A
18 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL10 IFNG
19 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
20 positive regulation of protein complex assembly GO:0031334 9.54 TNF IFNG CLEC7A
21 positive regulation of killing of cells of other organism GO:0051712 9.51 IFNG CLEC7A
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 TNF IL10
23 regulation of immunoglobulin secretion GO:0051023 9.48 TNF CD40LG
24 B cell proliferation GO:0042100 9.33 IL10 CD79A CD40LG
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IFNG
26 receptor biosynthetic process GO:0032800 9.26 TNF IL10
27 positive regulation of vitamin D biosynthetic process GO:0060557 8.96 TNF IFNG
28 positive regulation of nitrogen compound metabolic process GO:0051173 8.62 TNF IFNG

Molecular functions related to Sporotrichosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CD40LG

Sources for Sporotrichosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....