MCID: SPT005
MIFTS: 55

Spotted Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to flinders island spotted fever and african tick-bite fever, and has symptoms including fever, headache and fatigue. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Permethrin and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include endothelial cell of artery or, skin and endothelial, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 76 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 flinders island spotted fever 33.6 AFF2 PLEKHG4
2 african tick-bite fever 33.4 CCL5 IFNG
3 boutonneuse fever 33.3 AFF2 THBD
4 japanese spotted fever 33.0 AFF2 CXCL10 PLEKHG4
5 endemic typhus 32.0 AFF2 PLEKHG4
6 q fever 30.8 IFNG IL10 TNF
7 meningitis 30.4 IFNG IL10 TNF
8 vasculitis 30.1 THBD TNF VWF
9 connective tissue disease 30.0 IFNG IL10 TNF
10 retinal artery occlusion 29.9 F2 IL10
11 adult respiratory distress syndrome 29.8 F2 IL10 TNF
12 typhoid fever 29.6 F2 IFNG TNF
13 uveitis 29.3 CXCL10 IFNG IL10 TNF
14 purpura 29.1 F2 THBD TNF VWF
15 stroke, ischemic 28.8 F2 THBD VWF
16 vascular disease 28.8 F2 THBD TNF VWF
17 rocky mountain spotted fever 12.7
18 far eastern spotted fever 12.4
19 astrakhan spotted fever 12.3
20 rickettsia parkeri spotted fever 12.2
21 queensland tick typhus 11.8
22 siberian tick typhus 11.8
23 rickettsialpox 11.7
24 israeli tick typhus 11.5
25 aneruptive fever 11.5
26 colorado tick fever 11.1
27 indian tick typhus 11.1
28 punctate inner choroidopathy 10.8 IL10 TNF
29 tropical endomyocardial fibrosis 10.8 IL10 TNF
30 staphylococcal toxic shock syndrome 10.8 IFNG TNF
31 cat-scratch disease 10.8 HTRA1 IFNG
32 autoimmune myocarditis 10.8 IFNG TNF
33 trichosporonosis 10.8 IFNG TNF
34 microscopic polyangiitis 10.8 IL10 TNF
35 chronic beryllium disease 10.8 IFNG TNF
36 tungiasis 10.8 IL10 TNF
37 endomyocardial fibrosis 10.8 IL10 TNF
38 transient hypogammaglobulinemia 10.8 IL10 TNF
39 hyperlucent lung 10.8 IFNG IL10
40 idiopathic achalasia 10.7 IL10 TNF
41 sporotrichosis 10.7 IFNG IL10
42 trichuriasis 10.7 IL10 TNF
43 mucocutaneous leishmaniasis 10.7 IL10 TNF
44 baylisascariasis 10.7 IFNG IL10
45 crohn's colitis 10.7 IFNG TNF
46 microscopic colitis 10.7 IFNG TNF
47 meconium aspiration syndrome 10.7 IFNG TNF
48 chronic graft versus host disease 10.7 IFNG IL10
49 critical limb ischemia 10.7 TNF VWF
50 pericardial tuberculosis 10.7 IFNG IL10

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

Symptoms:

12
  • fever
  • headache
  • fatigue
  • muscle aches
  • maculopapular or petechial rash

MGI Mouse Phenotypes related to Spotted Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 IFNG IL10 THBD TNF VWF CXCL10
2 digestive/alimentary MP:0005381 9.63 IFNG IL10 THBD TNF VWF F2
3 hematopoietic system MP:0005397 9.56 IFNG IL10 THBD TNF VWF CCL5
4 immune system MP:0005387 9.23 IFNG IL10 THBD TNF VWF CCL5

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
2 Antibodies
3 Immunoglobulins
4 Immunoglobulin A
5 Immunoglobulin G
6 Immunoglobulin M
7 Anti-Bacterial Agents Not Applicable
8 Antibiotics, Antitubercular Not Applicable
9 Anti-Infective Agents Not Applicable
10 Antitubercular Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
3 Tick-borne Illness and Clothing Study Completed NCT01454414 Not Applicable
4 Lyme Test Indication Combinations (LyTIC) Study Recruiting NCT03201042
5 The Impact of C-reactive Protein Testing Recruiting NCT02758821 Not Applicable

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

The Foundational Model of Anatomy Ontology organs/tissues related to Spotted Fever:

19
Endothelial Cell Of Artery Or

MalaCards organs/tissues related to Spotted Fever:

41
Skin, Endothelial, Testes, Liver, Brain, T Cells, Monocytes

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1087)
# Title Authors Year
1
Heterogeneity in skin manifestations of spotted fever group rickettsial infection in Australia. ( 29767831 )
2018
2
Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama. ( 29619916 )
2018
3
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
4
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. ( 29722440 )
2018
5
Important Clinical Features of Japanese Spotted Fever. ( 29968555 )
2018
6
Timeliness in the notification of spotted fever in Brazil: Evaluating compulsory reporting strategies and digital disease detection. ( 29730381 )
2018
7
Japanese spotted fever. ( 29660067 )
2018
8
Two Cases of Israeli Spotted Fever with Purpura Fulminans, Sharon District, Israel. ( 29664383 )
2018
9
Development of a loop-mediated isothermal amplification (LAMP) assay for rapid screening of ticks and fleas for spotted fever group rickettsia. ( 29390021 )
2018
10
Fatal spotted fever rickettsiosis in Argentina. ( 29942776 )
2018
11
Possible Northward Introgression of a Tropical Lineage of Rhipicephalus sanguineus Ticks at a Site of Emerging Rocky Mountain Spotted Fever. ( 29553918 )
2018
12
Molecular detection of spotted fever group rickettsiae in ticks from Cameroon. ( 29636236 )
2018
13
Rocky Mountain spotted fever: brain imaging findings. ( 29500944 )
2018
14
The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature. ( 29685474 )
2018
15
Confirming Rickettsia rickettsii as the etiological agent of lethal spotted fever group rickettsiosis in human patients from EspA-rito Santo state, Brazil. ( 29371125 )
2018
16
Spotted fever group Rickettsiae in Ticks from Missouri. ( 29960871 )
2018
17
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
18
Identification and molecular characterization of spotted fever group rickettsiae in ticks collected from farm ruminants in Lebanon. ( 29054546 )
2018
19
Medical knowledge related to Rocky Mountain spotted fever in Sonora, Mexico. ( 29617892 )
2018
20
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. ( 29848404 )
2018
21
Dogs as sentinels for distribution of spotted-fever group rickettsiae in Slovakia. ( 29800723 )
2018
22
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
23
New records of tick-associated spotted fever group Rickettsia in an Amazon-Savannah ecotone, Brazil. ( 29625922 )
2018
24
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. ( 29855412 )
2018
25
Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia. ( 29054570 )
2018
26
Fatal case of spotted fever in a patient from Northeastern Brazil. ( 29846472 )
2018
27
Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. ( 29107656 )
2018
28
Tick borne illness - Rocky mountain spotted fever. ( 29549965 )
2018
29
Diversity of rickettsiae and potential vectors of spotted fever in an area of epidemiological interest in the Cerrado biome, midwestern Brazil. ( 29972600 )
2018
30
Association of the occurrence of Brazilian spotted fever and Atlantic rain forest fragmentation in the SALo Paulo metropolitan region, Brazil. ( 27880877 )
2017
31
The Detection of Spotted Fever Group Rickettsia DNA in Tick Samples From Pastoral Communities in Kenya. ( 28073909 )
2017
32
Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico. ( 28722584 )
2017
33
Rickettsia gravesii sp. nov.: a novel spotted fever group rickettsia in Western Australian Amblyomma triguttatum triguttatum ticks. ( 28857025 )
2017
34
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. ( 28775717 )
2017
35
Atypical Presentation Of Rickettsial Spotted Fever. ( 29331008 )
2017
36
Development of an electrochemical immunosensor for the diagnostic testing of spotted fever using synthetic peptides. ( 28886455 )
2017
37
Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016. ( 28930006 )
2017
38
Molecular detection of Rickettsia rhipicephali and other spotted fever group Rickettsia species in Amblyomma ticks infesting wild birds in the state of Minas Gerais, Brazil. ( 27745888 )
2017
39
Geographical Distribution of Japanese Spotted Fever and Tsutsugamushi Disease in Japan - Possible Effect of Environmental Temperature. ( 28250253 )
2017
40
Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. ( 28598270 )
2017
41
Detection of Spotted Fever Group Rickettsia DNA by Deep Sequencing. ( 29048295 )
2017
42
Spotted fever rickettsiae in wild-living rodents from south-western Poland. ( 28874204 )
2017
43
Evaluation of a Spotted Fever Group Rickettsia Public Health Surveillance System in Tennessee. ( 28722610 )
2017
44
Seroprevalence of Scrub Typhus, Typhus, and Spotted Fever Among Rural and Urban Populations of Northern Vietnam. ( 28500808 )
2017
45
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. ( 28806774 )
2017
46
Tick, Rickettsia Rickettsiae (Rocky Mountain Spotted Fever) ( 28613631 )
2017
47
Spotted Fever: Epidemiology and Vector-Rickettsia-Host Relationship in Rio de Janeiro State. ( 28424664 )
2017
48
Spotted fever rickettsiae and tuberculous meningitis dual infection presenting as acute encephalitis syndrome: A fatal case report. ( 28748844 )
2017
49
Black spot or A<tache noireA> in mediterranean spotted fever. ( 29173984 )
2017
50
Evidence of infection with Leptospira interrogans and spotted fever group rickettsiae among rodents in an urban area of Osaka City, Japan. ( 28529271 )
2017

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 CCL5 CXCL10 IFNG IL10 TNF VWF
2
Show member pathways
12.73 CCL5 CXCL10 IFNG IL10 TNF
3
Show member pathways
12.59 CCL5 CXCL10 IFNG TNF
4
Show member pathways
12.55 CCL5 CXCL10 IFNG TNF
5
Show member pathways
12.36 F2 IFNG IL10 TNF
6
Show member pathways
12.09 IFNG IL10 TNF
7
Show member pathways
12.08 IFNG IL10 TNF
8 12.07 CCL5 CXCL10 IFNG IL10 TNF
9 12.05 IFNG IL10 TNF
10
Show member pathways
12.04 CCL5 F2 IFNG TNF
11
Show member pathways
12 CXCL10 IFNG TNF
12
Show member pathways
11.97 F2 THBD VWF
13 11.89 F2 THBD VWF
14 11.89 IFNG THBD TNF
15 11.81 CXCL10 IFNG TNF
16 11.79 IFNG IL10 TNF
17 11.75 CCL5 CXCL10 TNF
18 11.67 IFNG IL10 TNF
19 11.63 CCL5 IFNG TNF
20 11.51 IFNG IL10 TNF
21 11.23 IFNG IL10 TNF
22 11.13 CCL5 F2
23 11.13 IFNG IL10 THBD TNF
24 11.04 IFNG IL10
25 11.04 IFNG IL10 TNF
26 11.02 F2 IFNG
27 10.99 CCL5 TNF
28 10.91 IFNG IL10 TNF
29 10.61 CCL5 CXCL10 IL10 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 extracellular space GO:0005615 9.23 CCL5 CXCL10 F2 HTRA1 IFNG IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.87 CCL5 CXCL10 IL10 TNF
2 blood coagulation GO:0007596 9.83 F2 THBD VWF
3 response to lipopolysaccharide GO:0032496 9.83 CXCL10 IL10 THBD
4 cytokine-mediated signaling pathway GO:0019221 9.81 CCL5 CXCL10 IL10 TNF
5 positive regulation of protein phosphorylation GO:0001934 9.79 F2 IFNG TNF
6 immune response GO:0006955 9.77 CCL5 CXCL10 IFNG IL10 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.76 CXCL10 IL10 TNF
8 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
9 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.64 CXCL10 F2
10 protein import into nucleus, translocation GO:0000060 9.64 IFNG TNF
11 negative regulation of interleukin-6 production GO:0032715 9.63 IL10 TNF
12 positive regulation of JAK-STAT cascade GO:0046427 9.63 CCL5 F2
13 regulation of insulin secretion GO:0050796 9.63 CCL5 IFNG TNF
14 positive regulation of protein complex assembly GO:0031334 9.62 IFNG TNF
15 negative regulation of myoblast differentiation GO:0045662 9.62 CXCL10 TNF
16 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
17 blood coagulation, intrinsic pathway GO:0007597 9.6 F2 VWF
18 positive regulation of monocyte chemotaxis GO:0090026 9.59 CCL5 CXCL10
19 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
20 hemostasis GO:0007599 9.58 F2 THBD VWF
21 positive regulation of T cell migration GO:2000406 9.56 CCL5 CXCL10
22 negative regulation of growth of symbiont in host GO:0044130 9.55 IL10 TNF
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL10 TNF
24 negative regulation of fibrinolysis GO:0051918 9.52 F2 THBD
25 negative regulation of platelet activation GO:0010544 9.49 F2 THBD
26 endothelial cell apoptotic process GO:0072577 9.48 IL10 TNF
27 negative regulation of cytokine secretion involved in immune response GO:0002740 9.43 IL10 TNF
28 receptor biosynthetic process GO:0032800 9.32 IL10 TNF
29 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG TNF
30 response to virus GO:0009615 9.26 CCL5 CXCL10 IFNG TNF
31 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
32 regulation of signaling receptor activity GO:0010469 9.1 CCL5 CXCL10 F2 IFNG IL10 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....