MCID: SPT005
MIFTS: 53

Spotted Fever

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to flinders island spotted fever and japanese spotted fever. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Permethrin and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and testes, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 76 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 flinders island spotted fever 33.8 AFF2 PLEKHG4
2 japanese spotted fever 33.7 AFF2 CXCL10 PLEKHG4
3 boutonneuse fever 33.6 AFF2 THBD
4 african tick-bite fever 33.0 CCL5 IFNG
5 endemic typhus 32.2 AFF2 PLEKHG4
6 indian tick typhus 31.9 AFF2 PLEKHG4
7 q fever 30.5 IFNG IL10 TNF
8 meningitis 30.2 IFNG IL10 TNF
9 vasculitis 30.1 THBD TNF VWF
10 typhoid fever 29.9 F2 IFNG TNF
11 adult respiratory distress syndrome 29.8 F2 IL10 TNF
12 connective tissue disease 29.8 IFNG IL10 TNF
13 uveitis 29.8 CXCL10 IFNG IL10 TNF
14 purpura 29.7 F2 THBD TNF VWF
15 stroke, ischemic 29.6 F2 THBD VWF
16 thrombosis 29.4 F2 THBD VWF
17 vascular disease 29.3 F2 THBD TNF VWF
18 rocky mountain spotted fever 12.8
19 far eastern spotted fever 12.6
20 astrakhan spotted fever 12.5
21 rickettsia parkeri spotted fever 12.4
22 siberian tick typhus 12.0
23 queensland tick typhus 11.9
24 israeli tick typhus 11.9
25 rickettsialpox 11.9
26 aneruptive fever 11.7
27 colorado tick fever 11.3
28 scrub typhus 10.3
29 crohn's colitis 10.3 IFNG TNF
30 cytomegalovirus retinitis 10.3 IFNG TNF
31 meconium aspiration syndrome 10.3 IFNG TNF
32 posterior uveitis 10.3 IFNG TNF
33 central nervous system vasculitis 10.3 IFNG TNF
34 lichen disease 10.3 IFNG TNF
35 tuberculous peritonitis 10.3 IFNG TNF
36 miliary tuberculosis 10.3 IFNG TNF
37 soft tissue sarcoma 10.3 IFNG TNF
38 post-transplant lymphoproliferative disease 10.3 IL10 TNF
39 autoimmune gastritis 10.3 IL10 TNF
40 trachoma 10.3 IL10 TNF
41 multidrug-resistant tuberculosis 10.3 IL10 TNF
42 mucocutaneous leishmaniasis 10.3 IL10 TNF
43 transverse myelitis 10.3 IL10 TNF
44 buruli ulcer 10.3 IFNG IL10
45 tuberculoid leprosy 10.3 IFNG IL10
46 hand, foot and mouth disease 10.3 IFNG IL10
47 pericardial tuberculosis 10.3 IFNG IL10
48 fascioliasis 10.3 IFNG IL10
49 osteosclerotic myeloma 10.2 TNF VWF
50 punctate inner choroidopathy 10.2 IL10 TNF

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

MGI Mouse Phenotypes related to Spotted Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 CXCL10 F2 HTRA1 IFNG IL10 THBD
2 digestive/alimentary MP:0005381 9.63 F2 IFNG IL10 THBD TNF VWF
3 hematopoietic system MP:0005397 9.56 CCL5 CXCL10 F2 IFNG IL10 THBD
4 immune system MP:0005387 9.23 CCL5 CXCL10 F2 IFNG IL10 THBD

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
2 Immunologic Factors
3 Immunoglobulins
4 Antibodies
5 Antibiotics, Antitubercular Not Applicable
6 Antitubercular Agents Not Applicable
7 Anti-Infective Agents Not Applicable
8 Anti-Bacterial Agents Not Applicable
9 Immunoglobulin A
10 Immunoglobulin G
11 Immunoglobulin M

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
3 Tick-borne Illness and Clothing Study Completed NCT01454414 Not Applicable
4 The Impact of C-reactive Protein Testing Completed NCT02758821 Not Applicable
5 Lyme Test Indication Combinations (LyTIC) Study Terminated NCT03201042

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

MalaCards organs/tissues related to Spotted Fever:

41
Skin, Endothelial, Testes, Brain, T Cells, Monocytes, Lung

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1502)
# Title Authors Year
1
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ( 30197269 )
2019
2
Heterogeneity in skin manifestations of spotted fever group rickettsial infection in Australia. ( 29767831 )
2018
3
Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama. ( 29619916 )
2018
4
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
5
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. ( 29722440 )
2018
6
Important Clinical Features of Japanese Spotted Fever. ( 29968555 )
2018
7
Timeliness in the notification of spotted fever in Brazil: Evaluating compulsory reporting strategies and digital disease detection. ( 29730381 )
2018
8
Japanese spotted fever. ( 29660067 )
2018
9
Two Cases of Israeli Spotted Fever with Purpura Fulminans, Sharon District, Israel. ( 29664383 )
2018
10
Development of a loop-mediated isothermal amplification (LAMP) assay for rapid screening of ticks and fleas for spotted fever group rickettsia. ( 29390021 )
2018
11
Fatal spotted fever rickettsiosis in Argentina. ( 29942776 )
2018
12
Possible Northward Introgression of a Tropical Lineage of Rhipicephalus sanguineus Ticks at a Site of Emerging Rocky Mountain Spotted Fever. ( 29553918 )
2018
13
Molecular detection of spotted fever group rickettsiae in ticks from Cameroon. ( 29636236 )
2018
14
Rocky Mountain spotted fever: brain imaging findings. ( 29500944 )
2018
15
The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature. ( 29685474 )
2018
16
Confirming Rickettsia rickettsii as the etiological agent of lethal spotted fever group rickettsiosis in human patients from EspA-rito Santo state, Brazil. ( 29371125 )
2018
17
Spotted fever group Rickettsiae in Ticks from Missouri. ( 29960871 )
2018
18
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
19
Identification and molecular characterization of spotted fever group rickettsiae in ticks collected from farm ruminants in Lebanon. ( 29054546 )
2018
20
Medical knowledge related to Rocky Mountain spotted fever in Sonora, Mexico. ( 29617892 )
2018
21
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. ( 29848404 )
2018
22
Dogs as sentinels for distribution of spotted-fever group rickettsiae in Slovakia. ( 29800723 )
2018
23
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
24
New records of tick-associated spotted fever group Rickettsia in an Amazon-Savannah ecotone, Brazil. ( 29625922 )
2018
25
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. ( 29855412 )
2018
26
Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia. ( 29054570 )
2018
27
Fatal case of spotted fever in a patient from Northeastern Brazil. ( 29846472 )
2018
28
Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. ( 29107656 )
2018
29
Tick borne illness - Rocky mountain spotted fever. ( 29549965 )
2018
30
Diversity of rickettsiae and potential vectors of spotted fever in an area of epidemiological interest in the Cerrado biome, midwestern Brazil. ( 29972600 )
2018
31
Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015. ( 30124190 )
2018
32
Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. ( 30298801 )
2018
33
Japanese Spotted Fever in Eastern China, 2013. ( 30334711 )
2018
34
Rickettsia rickettsii whole cell antigens offer protection against Rocky Mountain spotted fever in the canine host. ( 30396898 )
2018
35
Septic Shock Caused by Rocky Mountain Spotted Fever in a Suburban Texas Patient with Pet Dog Exposure: A Case Report. ( 30076285 )
2018
36
Molecular Confirmation of Rocky Mountain Spotted Fever Epidemic Agent in Mexicali, Mexico. ( 30124418 )
2018
37
Rickettsia sp. Strain NOD Infecting Ticks ( Amblyomma nodosum) in an Endemic Area of Spotted Fever in Brazil. ( 29261444 )
2018
38
Clinically-diagnosed Mediterranean Spotted Fever in Malta. ( 29462726 )
2018
39
Detection and characterization of a novel spotted fever group Rickettsia genotype in Haemaphysalis leporispalustris from California, USA. ( 29545107 )
2018
40
Rickettsia amblyommatis infecting Amblyomma pseudoconcolor in area of new focus of spotted fever in northeast Brazil. ( 29545159 )
2018
41
Case Report: Typhoid Fever and Spotted Fever Group Rickettsiosis Presenting Concomitantly in an Indian Immigrant. ( 30062981 )
2018
42
Zoonotic Anaplasma phagocytophilum, Ehrlichia canis, Dirofilaria immitis, Borrelia burgdorferi, and spotted fever group rickettsiae (SFGR) in different types of dogs. ( 30066107 )
2018
43
First molecular detection of the human pathogen Rickettsia raoultii and other spotted fever group rickettsiae in Ixodid ticks from wild and domestic mammals. ( 30078071 )
2018
44
Exposure of Owned Dogs and Feeding Ticks to Spotted Fever Group Rickettsioses in Central Italy. ( 30129908 )
2018
45
Serologic assessment for exposure to spotted fever group rickettsiae in dogs in the Arizona-Sonora border region. ( 30133168 )
2018
46
Clinicopathological study on rickettsial spotted fever from south India. ( 30139305 )
2018
47
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. ( 30150470 )
2018
48
Evidence of locally acquired spotted fever group rickettsioses in Southeast Texas, 2008-2016. ( 30152119 )
2018
49
Molecular evidence and diversity of the spotted-fever group Rickettsia spp. in small mammals from natural, suburban and urban areas of Eastern Slovakia. ( 30207272 )
2018
50
Basic reproduction number for the Brazilian Spotted Fever. ( 30222963 )
2018

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CCL5 CXCL10 IFNG IL10 TNF VWF
2
Show member pathways
12.76 CCL5 CXCL10 IFNG IL10 TNF
3
Show member pathways
12.61 CCL5 CXCL10 IFNG TNF
4
Show member pathways
12.58 CCL5 CXCL10 IFNG TNF
5
Show member pathways
12.38 F2 IFNG IL10 TNF
6 12.17 CCL5 CXCL10 IFNG IL10 TNF
7
Show member pathways
12.1 IFNG IL10 TNF
8
Show member pathways
12.09 CCL5 F2 IFNG TNF
9 12.07 IFNG IL10 TNF
10
Show member pathways
12.02 CXCL10 IFNG TNF
11
Show member pathways
11.99 F2 THBD VWF
12 11.92 F2 THBD VWF
13 11.92 IFNG THBD TNF
14
Show member pathways
11.88 IFNG IL10 TNF
15
Show member pathways
11.86 F2 IFNG TNF
16 11.83 CXCL10 IFNG TNF
17 11.81 IFNG IL10 TNF
18 11.78 CCL5 CXCL10 TNF
19 11.69 IFNG IL10 TNF
20 11.65 CCL5 IFNG TNF
21 11.56 IFNG IL10 TNF
22 11.33 IFNG IL10 THBD TNF
23 11.3 IFNG IL10 TNF
24 11.15 CCL5 F2
25 11.09 IFNG IL10 TNF
26 11.06 IFNG IL10
27 11.04 F2 IFNG
28 11.01 CCL5 TNF
29 10.96 IFNG IL10 TNF
30 10.95 CCL5 CXCL10 IL10 TNF
31 10.94 CCL5 CXCL10 IL10 TNF
32 10.87 CCL5 CXCL10 IFNG IL10 TNF
33 10.86 CCL5 CXCL10 IL10 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 extracellular space GO:0005615 9.23 CCL5 CXCL10 F2 HTRA1 IFNG IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CCL5 CXCL10 IL10 TNF
2 blood coagulation GO:0007596 9.83 F2 THBD VWF
3 positive regulation of protein phosphorylation GO:0001934 9.82 F2 IFNG TNF
4 response to lipopolysaccharide GO:0032496 9.8 CXCL10 IL10 THBD
5 cytokine-mediated signaling pathway GO:0019221 9.8 CCL5 CXCL10 IL10 TNF
6 cellular response to lipopolysaccharide GO:0071222 9.79 CXCL10 IL10 TNF
7 immune response GO:0006955 9.77 CCL5 CXCL10 IFNG IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.67 IL10 TNF
9 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.66 CXCL10 F2
10 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
11 regulation of synapse organization GO:0050807 9.65 IL10 TNF
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 CCL5 F2 TNF
13 positive regulation of JAK-STAT cascade GO:0046427 9.64 CCL5 F2
14 negative regulation of myoblast differentiation GO:0045662 9.64 CXCL10 TNF
15 positive regulation of protein complex assembly GO:0031334 9.63 IFNG TNF
16 leukocyte chemotaxis GO:0030595 9.63 CXCL10 IL10
17 protein import into nucleus, translocation GO:0000060 9.62 IFNG TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
19 regulation of insulin secretion GO:0050796 9.61 CCL5 IFNG TNF
20 positive regulation of monocyte chemotaxis GO:0090026 9.6 CCL5 CXCL10
21 blood coagulation, intrinsic pathway GO:0007597 9.59 F2 VWF
22 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
23 positive regulation of T cell migration GO:2000406 9.58 CCL5 CXCL10
24 hemostasis GO:0007599 9.58 F2 THBD VWF
25 negative regulation of growth of symbiont in host GO:0044130 9.57 IL10 TNF
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
27 negative regulation of fibrinolysis GO:0051918 9.54 F2 THBD
28 negative regulation of platelet activation GO:0010544 9.52 F2 THBD
29 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
30 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
32 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
33 response to virus GO:0009615 9.26 CCL5 CXCL10 IFNG TNF
34 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
35 regulation of signaling receptor activity GO:0010469 9.1 CCL5 CXCL10 F2 IFNG IL10 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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