MCID: SPT005
MIFTS: 53

Spotted Fever

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Spotted Fever

Summaries for Spotted Fever

Disease Ontology : 12 A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has material basis in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite.

MalaCards based summary : Spotted Fever, also known as spotted fevers, is related to flinders island spotted fever and japanese spotted fever. An important gene associated with Spotted Fever is HTRA1 (HtrA Serine Peptidase 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Permethrin and carbamide peroxide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and endothelial, and related phenotypes are cardiovascular system and digestive/alimentary

Wikipedia : 77 A spotted fever is a type of tick-borne disease which presents on the skin. They are all caused by... more...

Related Diseases for Spotted Fever

Diseases related to Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 flinders island spotted fever 33.8 AFF2 PLEKHG4
2 japanese spotted fever 33.6 AFF2 CXCL10 PLEKHG4
3 boutonneuse fever 33.3 AFF2 THBD
4 african tick-bite fever 33.1 CCL5 IFNG
5 endemic typhus 32.2 AFF2 PLEKHG4
6 indian tick typhus 31.9 AFF2 PLEKHG4
7 q fever 30.7 IFNG IL10 TNF
8 meningitis 30.4 IFNG IL10 TNF
9 vasculitis 30.2 THBD TNF VWF
10 connective tissue disease 29.9 IFNG IL10 TNF
11 typhoid fever 29.9 F2 IFNG TNF
12 adult respiratory distress syndrome 29.8 F2 IL10 TNF
13 uveitis 29.7 CXCL10 IFNG IL10 TNF
14 purpura 29.6 F2 THBD TNF VWF
15 pulmonary edema 29.6 F2 IL10 TNF
16 stroke, ischemic 29.6 F2 THBD VWF
17 leptospirosis 29.4 F2 IFNG IL10 TNF
18 thrombosis 29.3 F2 THBD VWF
19 vascular disease 29.2 F2 THBD TNF VWF
20 rocky mountain spotted fever 12.9
21 far eastern spotted fever 12.6
22 astrakhan spotted fever 12.5
23 rickettsia parkeri spotted fever 12.5
24 siberian tick typhus 12.0
25 queensland tick typhus 12.0
26 israeli tick typhus 11.9
27 rickettsialpox 11.9
28 aneruptive fever 11.7
29 colorado tick fever 11.3
30 epidemic typhus 10.5
31 microscopic colitis 10.4 IFNG TNF
32 crohn's colitis 10.4 IFNG TNF
33 cytomegalovirus retinitis 10.4 IFNG TNF
34 meconium aspiration syndrome 10.4 IFNG TNF
35 posterior uveitis 10.4 IFNG TNF
36 central nervous system vasculitis 10.4 IFNG TNF
37 lichen disease 10.4 IFNG TNF
38 tuberculous peritonitis 10.4 IFNG TNF
39 soft tissue sarcoma 10.4 IFNG TNF
40 post-transplant lymphoproliferative disease 10.4 IL10 TNF
41 autoimmune gastritis 10.4 IL10 TNF
42 trachoma 10.4 IL10 TNF
43 multidrug-resistant tuberculosis 10.4 IL10 TNF
44 transverse myelitis 10.4 IL10 TNF
45 buruli ulcer 10.4 IFNG IL10
46 multicentric castleman disease 10.4 IFNG IL10
47 tuberculoid leprosy 10.4 IFNG IL10
48 hand, foot and mouth disease 10.4 IFNG IL10
49 pericardial tuberculosis 10.4 IFNG IL10
50 fascioliasis 10.4 IFNG IL10

Graphical network of the top 20 diseases related to Spotted Fever:



Diseases related to Spotted Fever

Symptoms & Phenotypes for Spotted Fever

MGI Mouse Phenotypes related to Spotted Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 CXCL10 F2 HTRA1 IFNG IL10 THBD
2 digestive/alimentary MP:0005381 9.63 F2 IFNG IL10 THBD TNF VWF
3 hematopoietic system MP:0005397 9.56 CCL5 CXCL10 F2 IFNG IL10 THBD
4 immune system MP:0005387 9.23 CCL5 CXCL10 F2 IFNG IL10 THBD

Drugs & Therapeutics for Spotted Fever

Drugs for Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
2
carbamide peroxide Approved 124-43-6
3 Immunoglobulins
4 Antibodies
5 Immunologic Factors
6 Antibiotics, Antitubercular Not Applicable
7 Antitubercular Agents Not Applicable
8 Anti-Bacterial Agents Not Applicable
9 Anti-Infective Agents Not Applicable
10 Immunoglobulin A
11 Immunoglobulin G
12 Immunoglobulin M

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
2 300 Antibody Diagnostic Test Kit Unknown status NCT01646411
3 Tick-borne Illness and Clothing Study Completed NCT01454414 Not Applicable
4 The Impact of C-reactive Protein Testing Completed NCT02758821 Not Applicable
5 Rickettsiae in Myanmar Not yet recruiting NCT03847870
6 Lyme Test Indication Combinations (LyTIC) Study Terminated NCT03201042

Search NIH Clinical Center for Spotted Fever

Genetic Tests for Spotted Fever

Anatomical Context for Spotted Fever

MalaCards organs/tissues related to Spotted Fever:

42
Skin, Testes, Endothelial, Brain, Kidney, T Cells, Monocytes

Publications for Spotted Fever

Articles related to Spotted Fever:

(show top 50) (show all 1636)
# Title Authors Year
1
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. ( 30635303 )
2019
2
Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host. ( 30396898 )
2019
3
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ( 30197269 )
2019
4
Spotted fever group Rickettsia infection and transmission dynamics in Amblyomma maculatum. ( 30642897 )
2019
5
Molecular detection of spotted fever group rickettsiae in ticks parasitizing pet dogs in Shihezi City, northwestern China. ( 30649634 )
2019
6
Molecular detection of a novel Babesia sp. and pathogenic spotted fever group rickettsiae in ticks collected from hedgehogs in Turkey: Haemaphysalis erinacei, a novel candidate vector for the genus Babesia. ( 30682550 )
2019
7
Rickettsia parkeri spotted fever and toxicosis by Ornithodoros: other tick bite-related entities to be known by dermatologists. ( 30726485 )
2019
8
Diversity of spotted fever group rickettsiae and their association with host ticks in Japan. ( 30728409 )
2019
9
Genetic diversity, population structure and rickettsias in Amblyomma ovale in areas of epidemiological interest for spotted fever in Brazil. ( 30746741 )
2019
10
Circulation of spotted fever group rickettsiae among dogs seropositive for Leishmania spp. in an urban area of Brazil. ( 30810651 )
2019
11
Diagnostic Methods Used to Classify Confirmed and Probable Cases of Spotted Fever Rickettsioses - United States, 2010-2015. ( 30870409 )
2019
12
A Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Trigger Differential Proteome Signatures in Macrophages. ( 30895174 )
2019
13
Heterogeneity in skin manifestations of spotted fever group rickettsial infection in Australia. ( 29767831 )
2018
14
Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama. ( 29619916 )
2018
15
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
16
Comparison of positive ratio for red meat-specific immunoglobulin E between endemic and non-endemic area for Japanese spotted fever in Mie Prefecture, Japan. ( 29722440 )
2018
17
Important Clinical Features of Japanese Spotted Fever. ( 29968555 )
2018
18
Timeliness in the notification of spotted fever in Brazil: Evaluating compulsory reporting strategies and digital disease detection. ( 29730381 )
2018
19
Japanese spotted fever. ( 29660067 )
2018
20
Two Cases of Israeli Spotted Fever with Purpura Fulminans, Sharon District, Israel. ( 29664383 )
2018
21
Development of a loop-mediated isothermal amplification (LAMP) assay for rapid screening of ticks and fleas for spotted fever group rickettsia. ( 29390021 )
2018
22
Fatal spotted fever rickettsiosis in Argentina. ( 29942776 )
2018
23
Possible Northward Introgression of a Tropical Lineage of Rhipicephalus sanguineus Ticks at a Site of Emerging Rocky Mountain Spotted Fever. ( 29553918 )
2018
24
Molecular detection of spotted fever group rickettsiae in ticks from Cameroon. ( 29636236 )
2018
25
Rocky Mountain spotted fever: brain imaging findings. ( 29500944 )
2018
26
The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature. ( 29685474 )
2018
27
Confirming Rickettsia rickettsii as the etiological agent of lethal spotted fever group rickettsiosis in human patients from EspA-rito Santo state, Brazil. ( 29371125 )
2018
28
Spotted fever group Rickettsiae in Ticks from Missouri. ( 29960871 )
2018
29
Two cases of Japanese spotted fever infected in Rokko mountain near urban area of southern Hyogo Prefecture. ( 29315729 )
2018
30
Identification and molecular characterization of spotted fever group rickettsiae in ticks collected from farm ruminants in Lebanon. ( 29054546 )
2018
31
Medical knowledge related to Rocky Mountain spotted fever in Sonora, Mexico. ( 29617892 )
2018
32
Diagnosis of Spotted Fever Group Rickettsioses in U.S. Travelers Returning from Africa, 2007-2016. ( 29848404 )
2018
33
Dogs as sentinels for distribution of spotted-fever group rickettsiae in Slovakia. ( 29800723 )
2018
34
Case Report: Family Cluster of Japanese Spotted Fever. ( 29363442 )
2018
35
New records of tick-associated spotted fever group Rickettsia in an Amazon-Savannah ecotone, Brazil. ( 29625922 )
2018
36
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. ( 29855412 )
2018
37
Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia. ( 29054570 )
2018
38
Fatal case of spotted fever in a patient from Northeastern Brazil. ( 29846472 )
2018
39
Molecular prevalence of spotted fever group rickettsiae in ticks from Qinghai Province, northwestern China. ( 29107656 )
2018
40
Tick borne illness - Rocky mountain spotted fever. ( 29549965 )
2018
41
Diversity of rickettsiae and potential vectors of spotted fever in an area of epidemiological interest in the Cerrado biome, midwestern Brazil. ( 29972600 )
2018
42
Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015. ( 30124190 )
2018
43
Case Report: Concurrent Sympatric Scrub Typhus and Japanese Spotted Fever in Japan. ( 30298801 )
2018
44
Japanese Spotted Fever in Eastern China, 2013. ( 30334711 )
2018
45
Spotted fever rickettsioses causing myocarditis and ARDS: a case from Sri Lanka. ( 30594148 )
2018
46
Septic Shock Caused by Rocky Mountain Spotted Fever in a Suburban Texas Patient with Pet Dog Exposure: A Case Report. ( 30076285 )
2018
47
Molecular Confirmation of Rocky Mountain Spotted Fever Epidemic Agent in Mexicali, Mexico. ( 30124418 )
2018
48
Clinically-diagnosed Mediterranean Spotted Fever in Malta. ( 29462726 )
2018
49
Detection and characterization of a novel spotted fever group Rickettsia genotype in Haemaphysalis leporispalustris from California, USA. ( 29545107 )
2018
50
Rickettsia amblyommatis infecting Amblyomma pseudoconcolor in area of new focus of spotted fever in northeast Brazil. ( 29545159 )
2018

Variations for Spotted Fever

Expression for Spotted Fever

Search GEO for disease gene expression data for Spotted Fever.

Pathways for Spotted Fever

Pathways related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.08 CCL5 CXCL10 IFNG IL10 TNF VWF
2
Show member pathways
12.93 CCL5 CXCL10 IFNG IL10 TNF
3
Show member pathways
12.58 CCL5 CXCL10 IFNG TNF
4
Show member pathways
12.41 CCL5 CXCL10 IFNG TNF
5
Show member pathways
12.38 F2 IFNG IL10 TNF
6 12.17 CCL5 CXCL10 IFNG IL10 TNF
7
Show member pathways
12.1 IFNG IL10 TNF
8
Show member pathways
12.09 CCL5 F2 IFNG TNF
9 12.07 IFNG IL10 TNF
10
Show member pathways
12.02 CXCL10 IFNG TNF
11
Show member pathways
11.99 F2 THBD VWF
12 11.92 F2 THBD VWF
13 11.92 IFNG THBD TNF
14
Show member pathways
11.88 IFNG IL10 TNF
15
Show member pathways
11.86 F2 IFNG TNF
16 11.83 CXCL10 IFNG TNF
17 11.81 IFNG IL10 TNF
18 11.78 CCL5 CXCL10 TNF
19 11.69 IFNG IL10 TNF
20 11.66 CCL5 IFNG TNF
21 11.56 IFNG IL10 TNF
22 11.33 IFNG IL10 THBD TNF
23 11.3 IFNG IL10 TNF
24 11.15 CCL5 F2
25 11.11 IFNG IL10 TNF
26 11.06 IFNG IL10
27 11.04 F2 IFNG
28 11.01 CCL5 TNF
29 10.96 IFNG IL10 TNF
30 10.95 CCL5 CXCL10 IL10 TNF
31 10.94 CCL5 CXCL10 IL10 TNF
32 10.87 CCL5 CXCL10 IFNG IL10 TNF
33 10.86 CCL5 CXCL10 IL10 TNF

GO Terms for Spotted Fever

Cellular components related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 CCL5 CXCL10 F2 HTRA1 IFNG IL10
2 extracellular space GO:0005615 9.23 CCL5 CXCL10 F2 HTRA1 IFNG IL10

Biological processes related to Spotted Fever according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.85 CCL5 CXCL10 IL10 TNF
2 blood coagulation GO:0007596 9.83 F2 THBD VWF
3 positive regulation of protein phosphorylation GO:0001934 9.82 F2 IFNG TNF
4 cytokine-mediated signaling pathway GO:0019221 9.8 CCL5 CXCL10 IL10 TNF
5 response to lipopolysaccharide GO:0032496 9.79 CXCL10 IL10 THBD
6 cellular response to lipopolysaccharide GO:0071222 9.79 CXCL10 IL10 TNF
7 immune response GO:0006955 9.77 CCL5 CXCL10 IFNG IL10 TNF
8 negative regulation of interleukin-6 production GO:0032715 9.66 IL10 TNF
9 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.66 CXCL10 F2
10 positive regulation of cytokine secretion GO:0050715 9.65 IL10 TNF
11 regulation of synapse organization GO:0050807 9.65 IL10 TNF
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 CCL5 F2 TNF
13 positive regulation of JAK-STAT cascade GO:0046427 9.64 CCL5 F2
14 negative regulation of myoblast differentiation GO:0045662 9.63 CXCL10 TNF
15 positive regulation of protein complex assembly GO:0031334 9.63 IFNG TNF
16 leukocyte chemotaxis GO:0030595 9.62 CXCL10 IL10
17 positive regulation of osteoclast differentiation GO:0045672 9.61 IFNG TNF
18 regulation of insulin secretion GO:0050796 9.61 CCL5 IFNG TNF
19 positive regulation of monocyte chemotaxis GO:0090026 9.6 CCL5 CXCL10
20 blood coagulation, intrinsic pathway GO:0007597 9.59 F2 VWF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 IFNG TNF
22 positive regulation of T cell migration GO:2000406 9.58 CCL5 CXCL10
23 hemostasis GO:0007599 9.58 F2 THBD VWF
24 negative regulation of growth of symbiont in host GO:0044130 9.57 IL10 TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL10 TNF
26 negative regulation of fibrinolysis GO:0051918 9.54 F2 THBD
27 negative regulation of platelet activation GO:0010544 9.52 F2 THBD
28 endothelial cell apoptotic process GO:0072577 9.51 IL10 TNF
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 IL10 TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 IFNG TNF
31 receptor biosynthetic process GO:0032800 9.26 IL10 TNF
32 response to virus GO:0009615 9.26 CCL5 CXCL10 IFNG TNF
33 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 IFNG TNF
34 regulation of signaling receptor activity GO:0010469 9.1 CCL5 CXCL10 F2 IFNG IL10 TNF

Molecular functions related to Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL5 CXCL10 IFNG IL10 TNF

Sources for Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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