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MCID: SPT024
MIFTS: 35

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spotted Fever Rickettsiosis

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MalaCards integrated aliases for Spotted Fever Rickettsiosis:

Name: Spotted Fever Rickettsiosis 58
Spotted Fever Rickettsiae Disease 58

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A77.0 A77.1 A77.2 more
Orphanet 58 ORPHA102022
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Summaries for Spotted Fever Rickettsiosis

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MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to epidemic typhus and iridocyclitis. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs carbamide peroxide and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include endothelial, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Spotted Fever Rickettsiosis

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Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 430)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 30.5 TNF IL10 CCL5
2 iridocyclitis 30.4 TNF IL10
3 spotted fever 30.1 TNF IL10 IFNG IDO1 CTLA4 CCL5
4 disease by infectious agent 29.9 TNF IL10 IFNG IDO1
5 leptospirosis 29.9 TNF IL10 IFNG
6 exanthem 29.9 TNF IL10 IFNG CTLA4
7 thrombocytopenia 29.8 TNF IL10 IFNG CTLA4
8 african tick-bite fever 29.6 TNF IL10 IFNG CCL5
9 q fever 29.6 TNF IL10 IFNG CCL5
10 scrub typhus 29.6 TNF IL10 IFNG IDO1
11 uveitis 29.5 TNF IL10 IFNG CTLA4
12 chlamydia 28.9 TNF NOS2 IL10 IFNG IDO1
13 immune deficiency disease 28.9 TNF IL10 IFNG IDO1 CTLA4 CCL5
14 rickettsial disease 10.5
15 rocky mountain spotted fever 10.5
16 boutonneuse fever 10.5
17 typhoid fever 10.3
18 chromium allergic contact dermatitis 10.2 IL10 CCL5
19 scorpion envenomation 10.2 TNF CCL5
20 vulvovaginitis 10.2 IL10 CCL5
21 near-fatal asthma 10.2 TNF CCL5
22 basidiobolomycosis 10.2 IL10 IDO1
23 ulcer of lower limbs 10.2 TNF CCL5
24 stachybotrys chartarum 10.2 TNF CCL5
25 myelitis 10.2 TNF IL10
26 status asthmaticus 10.2 IL10 CCL5
27 punctate inner choroidopathy 10.2 TNF IL10
28 tropical endomyocardial fibrosis 10.2 TNF IL10
29 endomyocardial fibrosis 10.2 TNF IL10
30 genital herpes 10.2 IL10 CCL5
31 multifocal choroiditis 10.1 TNF IL10
32 palladium allergic contact dermatitis 10.1 TNF IL10
33 tertiary syphilis 10.1 TNF IL10
34 radiculopathy 10.1 IL10 CCL5
35 bacterial conjunctivitis 10.1 TNF IL10
36 post-transplant lymphoproliferative disease 10.1 TNF IL10
37 hypopyon 10.1 TNF IL10
38 chemical colitis 10.1 TNF IL10
39 enterocolitis 10.1 TNF IL10
40 transient hypogammaglobulinemia 10.1 TNF IL10
41 progressive myoclonus epilepsy 8 10.1 TNF IL10
42 branchiootic syndrome 1 10.1
43 cyanosis, transient neonatal 10.1
44 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 10.1
45 chikungunya 10.1
46 endemic typhus 10.1
47 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.1
48 neuroretinitis 10.1
49 ehrlichiosis 10.1
50 neutropenia 10.1

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis
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Symptoms & Phenotypes for Spotted Fever Rickettsiosis

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MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CTLA4 IDO1 IFNG IL10 NOS2 TNF
2 hematopoietic system MP:0005397 9.87 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
3 immune system MP:0005387 9.8 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.77 CTLA4 IFNG IL10 NOS2 TNF
5 liver/biliary system MP:0005370 9.55 CTLA4 IFNG IL10 NOS2 TNF
6 muscle MP:0005369 9.35 IDO1 IFNG IL10 NOS2 TNF
7 respiratory system MP:0005388 9.02 CTLA4 IFNG IL10 NOS2 TNF
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Drugs & Therapeutics for Spotted Fever Rickettsiosis

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Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Completed NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

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Genetic Tests for Spotted Fever Rickettsiosis

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Anatomical Context for Spotted Fever Rickettsiosis

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MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

40
Endothelial
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Publications for Spotted Fever Rickettsiosis

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Articles related to Spotted Fever Rickettsiosis:

(show top 50) (show all 91)
# Title Authors PMID Year
1
MicroRNA-424 regulates the expression of CX3CL1 (fractalkine) in human microvascular endothelial cells during Rickettsia rickettsii infection. 61
33490646 2021
2
Beyond the IFA: Revisiting the ELISA as a More Sensitive, Objective, and Quantitative Evaluation of Spotted Fever Group Rickettsia Exposure. 61
33498380 2021
3
Rickettsia parkeri (Rickettsiales: Rickettsiaceae) in the Sky Islands of West Texas. 61
32249319 2020
4
Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis. 61
32493778 2020
5
Emerging tick-borne pathogens of public health importance: a mini-review. 61
32478654 2020
6
Antibody Titers Reactive With Rickettsia rickettsii in Blood Donors and Implications for Surveillance of Spotted Fever Rickettsiosis in the United States. 61
31267128 2020
7
Expanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017. 61
31638478 2020
8
Spotted fever rickettsiosis presenting with bilateral anterior uveitis and retinitis: A case report. 61
32318504 2020
9
An optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes. 61
31682796 2020
10
A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. 61
31604442 2019
11
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 61
31331735 2019
12
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 61
31134290 2019
13
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
14
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 61
31202622 2019
15
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 61
31216274 2019
16
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 61
30969821 2019
17
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 61
31084685 2019
18
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 61
30771038 2019
19
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 61
30635303 2019
20
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 61
30315767 2019
21
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
22
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 61
30618452 2018
23
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 61
30274426 2018
24
Fatal spotted fever rickettsiosis in Argentina. 61
29942776 2018
25
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 61
28764157 2017
26
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 61
28576950 2017
27
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 61
28806774 2017
28
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 61
27508322 2016
29
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 61
27318438 2016
30
A Clinical Review of Tick-Borne Diseases in Arkansas. 61
27263175 2016
31
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 61
26432518 2015
32
Spotted fever rickettsiosis in Uttar Pradesh. 61
25900962 2015
33
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 61
26394396 2015
34
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 61
25590681 2015
35
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 61
25533148 2014
36
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 61
25501172 2014
37
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 61
25108779 2014
38
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 61
24742108 2014
39
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 61
24218580 2013
40
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 61
23788593 2013
41
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 61
23363571 2013
42
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 61
23279233 2013
43
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 61
24155949 2013
44
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 61
23140893 2012
45
Gangrene in cases of spotted fever: a report of three cases. 61
23257640 2012
46
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 61
22541336 2012
47
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 61
22634883 2012
48
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 61
23101229 2012
49
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 61
22172164 2011
50
Rickettsia parkeri Rickettsiosis, Argentina. 61
21762568 2011
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Variations for Spotted Fever Rickettsiosis

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Expression for Spotted Fever Rickettsiosis

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Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.
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Pathways for Spotted Fever Rickettsiosis

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Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.75 TNF NOS2 IL10 IFNG CTLA4 CCL5
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.14 TNF NOS2 IL10 IFNG CCL5
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.99 TNF NOS2 IL10 IFNG CCL5
4
Allograft rejection 1 36
Show member pathways
 12.67 TNF IL10 IFNG CTLA4
5
T cell receptor signaling pathway 36
Show member pathways
 12.43 TNF IL10 IFNG CTLA4
6
Immune response IL-23 signaling pathway 23
Show member pathways
 12.41 TNF NOS2 IL10 IFNG
7
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.16 TNF IL10 CCL5
8
Folate Metabolism 1
Show member pathways
 12.16 TNF IFNG CCL5
9
Toll Comparative Pathway 63
Show member pathways
 12.13 TNF NOS2 IFNG
10
Colorectal Cancer Metastasis 63
12.03 TNF NOS2 IFNG
11
Bacterial infections in CF airways 23
Show member pathways
 12.03 TNF NOS2 IFNG
12
Toxoplasmosis 36
Show member pathways
 12.03 TNF NOS2 IL10 IFNG
13
Tuberculosis 36
11.96 TNF NOS2 IL10 IFNG
14
Spinal Cord Injury 1
11.87 TNF NOS2 IFNG
15
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.85 TNF IL10 IFNG
16
Interleukin-4 and 13 signaling 65
11.84 TNF NOS2 IL10
17
Innate Lymphoid Cell Differentiation Pathways 64
11.66 TNF IL10 IFNG
18
Amoebiasis 36
11.63 TNF NOS2 IL10 IFNG
19
Th1 Differentiation Pathway 64
Show member pathways
 11.62 TNF IL10 IFNG
20
Pertussis 36
11.61 TNF NOS2 IL10
21
NF-kappaB Signaling 4
11.61 TNF IL10 IFNG IDO1 CTLA4 CCL5
22
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.6 TNF IFNG CTLA4
23
Dendritic Cells Developmental Lineage Pathway 64
11.58 TNF IL10 IFNG
24
Rheumatoid arthritis 36
11.53 TNF IFNG CTLA4 CCL5
25
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.5 TNF NOS2 IFNG
26
Malaria 36
11.39 TNF IL10 IFNG
27
Interleukin-10 signaling 65
11.36 TNF IL10 CCL5
28
Th2 Differentiation Pathway 64
11.34 IL10 IFNG
29
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.33 TNF IFNG
30
MSP-RON Signaling 63
11.33 TNF NOS2 IFNG
31
IgA-Producing B Cells in the Intestine 64
11.28 TNF NOS2 IL10 CTLA4
32
Type II interferon signaling (IFNG) 1
11.24 NOS2 IFNG
33
IL-10 Pathway 63
11.21 TNF IL10
34
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.17 TNF IL10 IFNG
35
Development and heterogeneity of the ILC family 1
11.16 TNF IFNG
36
OX40 Pathway 63
11.07 IL10 IFNG
37
EBV LMP1 signaling 1
11.02 TNF CCL5
38
Cytokines and Inflammatory Response 1
11.01 TNF IL10 IFNG
39
African trypanosomiasis 36
10.82 TNF IL10 IFNG IDO1
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GO Terms for Spotted Fever Rickettsiosis

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Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.86 TNF NOS2 IFNG
2 inflammatory response GO:0006954 9.84 TNF NOS2 IDO1 CCL5
3 defense response to bacterium GO:0042742 9.83 TNF NOS2 IL10
4 response to lipopolysaccharide GO:0032496 9.81 NOS2 IL10 IDO1
5 cellular response to lipopolysaccharide GO:0071222 9.8 TNF NOS2 IL10
6 cytokine-mediated signaling pathway GO:0019221 9.76 TNF NOS2 IL10 CCL5
7 response to virus GO:0009615 9.74 TNF IFNG CCL5
8 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF IFNG
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.68 TNF IFNG
10 negative regulation of viral genome replication GO:0045071 9.68 TNF CCL5
11 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.68 TNF IL10
12 positive regulation of interleukin-12 production GO:0032735 9.67 IFNG IDO1
13 protein kinase B signaling GO:0043491 9.67 TNF CCL5
14 positive regulation of chemokine production GO:0032722 9.67 TNF IFNG
15 negative regulation of mitotic cell cycle GO:0045930 9.66 TNF IL10
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.66 TNF CCL5
17 microglial cell activation GO:0001774 9.65 TNF IFNG
18 regulation of synapse organization GO:0050807 9.65 TNF IL10
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TNF IFNG CCL5
20 positive regulation of osteoclast differentiation GO:0045672 9.64 TNF IFNG
21 positive regulation of amyloid-beta formation GO:1902004 9.64 TNF IFNG
22 negative regulation of B cell proliferation GO:0030889 9.63 IL10 CTLA4
23 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 TNF IFNG
24 astrocyte activation GO:0048143 9.61 TNF IFNG
25 regulation of regulatory T cell differentiation GO:0045589 9.61 IFNG CTLA4
26 positive regulation of cytokine production GO:0001819 9.61 TNF IL10 IFNG
27 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 TNF IL10
28 positive regulation of signaling receptor activity GO:2000273 9.59 IL10 IFNG
29 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
30 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IFNG
31 negative regulation of T cell apoptotic process GO:0070233 9.56 IDO1 CCL5
32 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
33 negative regulation of T cell proliferation GO:0042130 9.54 IL10 IDO1 CTLA4
34 positive regulation of T cell apoptotic process GO:0070234 9.52 IDO1 CCL5
35 positive regulation of killing of cells of other organism GO:0051712 9.51 NOS2 IFNG
36 negative regulation of cytokine production involved in immune response GO:0002719 9.49 TNF IL10
37 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IFNG
38 immune response GO:0006955 9.35 TNF IL10 IFNG CTLA4 CCL5
39 positive regulation of JAK-STAT cascade GO:0046427 9.33 TNF IL10 CCL5
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
41 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
42 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5
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Sources for Spotted Fever Rickettsiosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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