MCID: SPT024
MIFTS: 36

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Spotted Fever Rickettsiosis

MalaCards integrated aliases for Spotted Fever Rickettsiosis:

Name: Spotted Fever Rickettsiosis 58
Spotted Fever Rickettsiae Disease 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A77.0 A77.1 A77.2 more
Orphanet 58 ORPHA102022

Summaries for Spotted Fever Rickettsiosis

MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to iridocyclitis and neutropenia. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs carbamide peroxide and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and monocytes, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Spotted Fever Rickettsiosis

Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 30.2 TNF IL10
2 neutropenia 29.7 TNF IL10 IFNG
3 leptospirosis 29.7 TNF IL10 IFNG
4 exanthem 29.6 TNF IL10 IFNG CTLA4
5 spotted fever 29.5 TNF IL10 IFNG IDO1 CTLA4 CCL5
6 african tick-bite fever 29.3 TNF IL10 IFNG CCL5
7 q fever 29.3 TNF IL10 IFNG CCL5
8 uveitis 29.2 TNF IL10 IFNG CTLA4
9 scrub typhus 29.2 TNF IL10 IFNG IDO1
10 thrombocytopenia 29.2 TNF IL10 IFNG CTLA4
11 immune deficiency disease 28.8 TNF IL10 IFNG IDO1 CCL5
12 chlamydia 28.3 TNF NOS2 IL10 IFNG IDO1
13 rickettsial disease 10.5
14 rocky mountain spotted fever 10.5
15 boutonneuse fever 10.5
16 epidemic typhus 10.4
17 typhoid fever 10.3
18 scorpion envenomation 10.2 TNF CCL5
19 anaerobic pneumonia 10.2 TNF CCL5
20 stachybotrys chartarum 10.2 TNF CCL5
21 microscopic polyangiitis 10.2 TNF CTLA4
22 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG CCL5
23 skin sarcoidosis 10.2 TNF CTLA4
24 toxic oil syndrome 10.2 IFNG IDO1
25 intestinal perforation 10.1 TNF CTLA4
26 eosinophilia-myalgia syndrome 10.1 IFNG IDO1
27 staphylococcal toxic shock syndrome 10.1 TNF IFNG
28 autoimmune myocarditis 10.1 TNF IFNG
29 branchiootic syndrome 1 10.1
30 cyanosis, transient neonatal 10.1
31 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2 10.1
32 chikungunya 10.1
33 endemic typhus 10.1
34 inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2 10.1
35 neuroretinitis 10.1
36 ehrlichiosis 10.1
37 visual epilepsy 10.1
38 retinitis 10.1
39 47,xyy 10.1
40 splenomegaly 10.1
41 febrile seizures 10.1
42 seizure disorder 10.1
43 tremor 10.1
44 polyarticular juvenile idiopathic arthritis 10.1 TNF IFNG
45 vulvovaginitis 10.1 IL10 CCL5
46 chronic beryllium disease 10.1 TNF IFNG
47 soft tissue sarcoma 10.1 TNF IFNG
48 opportunistic bacterial infectious disease 10.1 TNF IFNG
49 eczema herpeticum 10.1 IFNG IDO1
50 gastrointestinal tuberculosis 10.1 TNF IFNG

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis

Symptoms & Phenotypes for Spotted Fever Rickettsiosis

MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.88 CTLA4 IDO1 IFNG IL10 NOS2 TNF
2 hematopoietic system MP:0005397 9.87 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
3 immune system MP:0005387 9.8 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.77 CTLA4 IFNG IL10 NOS2 TNF
5 liver/biliary system MP:0005370 9.55 CTLA4 IFNG IL10 NOS2 TNF
6 muscle MP:0005369 9.35 IDO1 IFNG IL10 NOS2 TNF
7 respiratory system MP:0005388 9.02 CTLA4 IFNG IL10 NOS2 TNF

Drugs & Therapeutics for Spotted Fever Rickettsiosis

Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Completed NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

Genetic Tests for Spotted Fever Rickettsiosis

Anatomical Context for Spotted Fever Rickettsiosis

MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

40
Testes, Skin, Monocytes, Endothelial

Publications for Spotted Fever Rickettsiosis

Articles related to Spotted Fever Rickettsiosis:

(show top 50) (show all 89)
# Title Authors PMID Year
1
Optimization and evaluation of a multiplex quantitative PCR assay for detection of nucleic acids in human blood from patients with spotted fever rickettsiosis, typhus rickettsiosis, scrub typhus, monocytic ehrlichiosis, and granulocytic anaplasmosis. 61
32493778 2020
2
Emerging tick-borne pathogens of public health importance: a mini-review. 61
32478654 2020
3
Rickettsia parkeri (Rickettsiales: Rickettsiaceae) in the Sky Islands of West Texas. 61
32249319 2020
4
Antibody Titers Reactive With Rickettsia rickettsii in Blood Donors and Implications for Surveillance of Spotted Fever Rickettsiosis in the United States. 61
31267128 2020
5
Expanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017. 61
31638478 2020
6
Spotted fever rickettsiosis presenting with bilateral anterior uveitis and retinitis: A case report. 61
32318504 2020
7
An optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes. 61
31682796 2020
8
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 61
31331735 2019
9
A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. 61
31604442 2019
10
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 61
31134290 2019
11
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
12
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 61
31202622 2019
13
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 61
31216274 2019
14
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 61
30969821 2019
15
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 61
31084685 2019
16
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 61
30771038 2019
17
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 61
30635303 2019
18
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
19
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 61
30315767 2019
20
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 61
30618452 2018
21
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 61
30274426 2018
22
Fatal spotted fever rickettsiosis in Argentina. 61
29942776 2018
23
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 61
28764157 2017
24
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 61
28576950 2017
25
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 61
28806774 2017
26
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 61
27508322 2016
27
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 61
27318438 2016
28
A Clinical Review of Tick-Borne Diseases in Arkansas. 61
27263175 2016
29
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 61
26432518 2015
30
Spotted fever rickettsiosis in Uttar Pradesh. 61
25900962 2015
31
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 61
25590681 2015
32
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 61
26394396 2015
33
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 61
25533148 2014
34
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 61
25501172 2014
35
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 61
25108779 2014
36
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 61
24742108 2014
37
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 61
24218580 2013
38
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 61
23788593 2013
39
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 61
23363571 2013
40
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 61
24155949 2013
41
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 61
23279233 2013
42
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 61
23140893 2012
43
Gangrene in cases of spotted fever: a report of three cases. 61
23257640 2012
44
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 61
22541336 2012
45
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 61
22634883 2012
46
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 61
23101229 2012
47
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 61
22172164 2011
48
Rickettsia parkeri Rickettsiosis, Argentina. 61
21762568 2011
49
An acarologic survey and Amblyomma americanum distribution map with implications for tularemia risk in Missouri. 61
21363979 2011
50
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. 61
21291605 2011

Variations for Spotted Fever Rickettsiosis

Expression for Spotted Fever Rickettsiosis

Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.

Pathways for Spotted Fever Rickettsiosis

Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TNF NOS2 IL10 IFNG CTLA4 CCL5
2
Show member pathways
13.13 TNF NOS2 IL10 IFNG CCL5
3
Show member pathways
12.8 TNF NOS2 IL10 IFNG CCL5
4
Show member pathways
12.66 TNF IL10 IFNG CTLA4
5
Show member pathways
12.43 TNF IL10 IFNG CTLA4
6
Show member pathways
12.4 TNF NOS2 IL10 IFNG
7
Show member pathways
12.16 TNF IL10 CCL5
8
Show member pathways
12.15 TNF IFNG CCL5
9
Show member pathways
12.13 TNF NOS2 IFNG
10 12.03 TNF NOS2 IFNG
11
Show member pathways
12.02 TNF NOS2 IFNG
12
Show member pathways
12.01 TNF NOS2 IL10 IFNG
13 11.92 TNF NOS2 IL10 IFNG
14 11.87 TNF NOS2 IFNG
15 11.85 TNF IL10 IFNG
16 11.83 TNF NOS2 IL10
17
Show member pathways
11.79 TNF IL10 IFNG
18 11.66 TNF IL10 IFNG
19 11.61 TNF NOS2 IL10
20 11.61 TNF IL10 IFNG IDO1 CTLA4 CCL5
21
Show member pathways
11.6 TNF IFNG CTLA4
22 11.58 TNF IL10 IFNG
23 11.57 TNF NOS2 IL10 IFNG
24
Show member pathways
11.5 TNF NOS2 IFNG
25 11.43 TNF IFNG CTLA4 CCL5
26 11.37 TNF IL10 IFNG
27 11.34 IL10 IFNG
28 11.34 TNF IL10 CCL5
29 11.32 TNF IFNG
30 11.31 TNF NOS2 IFNG
31 11.23 NOS2 IFNG
32 11.21 TNF IL10
33 11.16 TNF IFNG
34
Show member pathways
11.14 TNF IL10 IFNG
35 11.07 IL10 IFNG
36 11.02 TNF CCL5
37 10.96 TNF IL10 IFNG
38 10.82 TNF IL10 IFNG IDO1

GO Terms for Spotted Fever Rickettsiosis

Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.87 TNF NOS2 IFNG
2 inflammatory response GO:0006954 9.86 TNF NOS2 IDO1 CCL5
3 defense response to bacterium GO:0042742 9.85 TNF NOS2 IL10
4 cellular response to lipopolysaccharide GO:0071222 9.82 TNF NOS2 IL10
5 response to lipopolysaccharide GO:0032496 9.82 NOS2 IL10 IDO1
6 cytokine-mediated signaling pathway GO:0019221 9.78 TNF NOS2 IL10 CCL5
7 response to virus GO:0009615 9.77 TNF IFNG CCL5
8 interleukin-12-mediated signaling pathway GO:0035722 9.7 IL10 IFNG
9 extrinsic apoptotic signaling pathway GO:0097191 9.7 TNF IFNG
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 TNF IFNG
11 positive regulation of interleukin-6 secretion GO:2000778 9.69 TNF IFNG
12 negative regulation of viral genome replication GO:0045071 9.69 TNF CCL5
13 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.68 TNF IL10
14 protein kinase B signaling GO:0043491 9.68 TNF CCL5
15 negative regulation of mitotic cell cycle GO:0045930 9.68 TNF IL10
16 negative regulation of interleukin-6 production GO:0032715 9.68 TNF IL10
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF CCL5
18 microglial cell activation GO:0001774 9.67 TNF IFNG
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 TNF IFNG CCL5
20 regulation of synapse organization GO:0050807 9.66 TNF IL10
21 positive regulation of interleukin-12 production GO:0032735 9.66 IFNG IDO1
22 positive regulation of osteoclast differentiation GO:0045672 9.65 TNF IFNG
23 positive regulation of amyloid-beta formation GO:1902004 9.65 TNF IFNG
24 negative regulation of B cell proliferation GO:0030889 9.64 IL10 CTLA4
25 astrocyte activation GO:0048143 9.63 TNF IFNG
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 TNF IFNG
27 regulation of regulatory T cell differentiation GO:0045589 9.62 IFNG CTLA4
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF IL10
29 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TNF IFNG
30 negative regulation of amyloid-beta clearance GO:1900222 9.61 TNF IFNG
31 positive regulation of MHC class II biosynthetic process GO:0045348 9.6 IL10 IFNG
32 negative regulation of T cell apoptotic process GO:0070233 9.58 IDO1 CCL5
33 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.58 TNF IFNG
34 negative regulation of T cell proliferation GO:0042130 9.58 IL10 IDO1 CTLA4
35 endothelial cell apoptotic process GO:0072577 9.57 TNF IL10
36 positive regulation of T cell apoptotic process GO:0070234 9.55 IDO1 CCL5
37 positive regulation of killing of cells of other organism GO:0051712 9.54 NOS2 IFNG
38 negative regulation of cytokine production involved in immune response GO:0002719 9.52 TNF IL10
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.51 TNF IL10
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 TNF IFNG
41 receptor biosynthetic process GO:0032800 9.43 TNF IL10
42 positive regulation of cytokine secretion GO:0050715 9.43 TNF IL10 IFNG
43 positive regulation of vitamin D biosynthetic process GO:0060557 9.37 TNF IFNG
44 immune response GO:0006955 9.35 TNF IL10 IFNG CTLA4 CCL5
45 positive regulation of JAK-STAT cascade GO:0046427 9.33 TNF IL10 CCL5
46 positive regulation of nitrogen compound metabolic process GO:0051173 9.32 TNF IFNG
47 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5

Sources for Spotted Fever Rickettsiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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