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MCID: SPT024
MIFTS: 36

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spotted Fever Rickettsiosis

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MalaCards integrated aliases for Spotted Fever Rickettsiosis:

Name: Spotted Fever Rickettsiosis 58
Spotted Fever Rickettsiae Disease 58

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A77.0 A77.1 A77.2 more
Orphanet 58 ORPHA102022
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Summaries for Spotted Fever Rickettsiosis

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MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to exanthem and leptospirosis. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs carbamide peroxide and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and endothelial, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Spotted Fever Rickettsiosis

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Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.2 TNF IL10 CTLA4
2 leptospirosis 29.7 TNF IL10 IFNG
3 spotted fever 29.5 TNF IL10 IFNG IDO1 CTLA4 CCL5
4 african tick-bite fever 29.3 TNF IL10 IFNG CCL5
5 q fever 29.3 TNF IL10 IFNG CCL5
6 thrombocytopenia 29.2 TNF IL10 IFNG CTLA4
7 immune deficiency disease 28.8 TNF IL10 IFNG IDO1 CCL5
8 chlamydia 28.3 TNF NOS2 IL10 IFNG IDO1
9 boutonneuse fever 10.5
10 rickettsial disease 10.5
11 rocky mountain spotted fever 10.4
12 epidemic typhus 10.3
13 typhoid fever 10.3
14 scorpion envenomation 10.3 TNF CCL5
15 stachybotrys chartarum 10.2 TNF CCL5
16 microscopic polyangiitis 10.2 TNF CTLA4
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG CCL5
18 skin sarcoidosis 10.2 TNF CTLA4
19 autoimmune disease of cardiovascular system 10.2 TNF CTLA4
20 toxic oil syndrome 10.2 IFNG IDO1
21 urinary schistosomiasis 10.1 IFNG CTLA4
22 folliculitis 10.1 IFNG CCL5
23 eosinophilia-myalgia syndrome 10.1 IFNG IDO1
24 staphylococcal toxic shock syndrome 10.1 TNF IFNG
25 autoimmune myocarditis 10.1 TNF IFNG
26 branchiootic syndrome 1 10.1
27 cyanosis, transient neonatal 10.1
28 chikungunya 10.1
29 endemic typhus 10.1
30 visual epilepsy 10.1
31 neutropenia 10.1
32 47,xyy 10.1
33 splenomegaly 10.1
34 febrile seizures 10.1
35 seizure disorder 10.1
36 tremor 10.1
37 vulvovaginitis 10.1 IL10 CCL5
38 eczema herpeticum 10.1 IFNG IDO1
39 chronic beryllium disease 10.1 TNF IFNG
40 soft tissue sarcoma 10.1 TNF IFNG
41 gastrointestinal tuberculosis 10.1 TNF IFNG
42 bone sarcoma 10.1 IL10 CTLA4
43 intestinal tuberculosis 10.1 TNF IFNG
44 oral tuberculosis 10.1 TNF IFNG
45 inflammatory bowel disease 18 10.1 IL10 CTLA4
46 abdominal tuberculosis 10.1 TNF IFNG
47 myelitis 10.1 TNF IL10
48 lung abscess 10.1 TNF IFNG
49 miliary tuberculosis 10.1 TNF IFNG
50 viral meningitis 10.1 IFNG CCL5

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis
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Symptoms & Phenotypes for Spotted Fever Rickettsiosis

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MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CTLA4 IDO1 IFNG IL10 NOS2 TNF
2 hematopoietic system MP:0005397 9.91 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
3 immune system MP:0005387 9.87 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.8 CTLA4 IFNG IL10 NOS2 TNF
5 integument MP:0010771 9.65 CTLA4 IFNG IL10 NOS2 TNF
6 liver/biliary system MP:0005370 9.55 CTLA4 IFNG IL10 NOS2 TNF
7 muscle MP:0005369 9.35 IDO1 IFNG IL10 NOS2 TNF
8 respiratory system MP:0005388 9.02 CTLA4 IFNG IL10 NOS2 TNF
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Drugs & Therapeutics for Spotted Fever Rickettsiosis

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Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

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Genetic Tests for Spotted Fever Rickettsiosis

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Anatomical Context for Spotted Fever Rickettsiosis

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MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

40
Testes, Skin, Endothelial
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Publications for Spotted Fever Rickettsiosis

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Articles related to Spotted Fever Rickettsiosis:

(show top 50) (show all 85)
# Title Authors PMID Year
1
An optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes. 61
31682796 2019
2
A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. 61
31604442 2019
3
Expanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017. 61
31638478 2019
4
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 61
31331735 2019
5
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 61
31134290 2019
6
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
7
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 61
31202622 2019
8
Antibody titers reactive with Rickettsia rickettsii in blood donors and implications for surveillance of spotted fever rickettsiosis in the United States. 61
31267128 2019
9
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 61
31216274 2019
10
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 61
30969821 2019
11
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 61
31084685 2019
12
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 61
30771038 2019
13
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 61
30315767 2019
14
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 61
30635303 2019
15
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
16
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 61
30618452 2018
17
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 61
30274426 2018
18
Fatal spotted fever rickettsiosis in Argentina. 61
29942776 2018
19
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 61
28764157 2017
20
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 61
28576950 2017
21
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 61
28806774 2017
22
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 61
27508322 2016
23
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 61
27318438 2016
24
A Clinical Review of Tick-Borne Diseases in Arkansas. 61
27263175 2016
25
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 61
26432518 2015
26
Spotted fever rickettsiosis in Uttar Pradesh. 61
25900962 2015
27
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 61
25590681 2015
28
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 61
26394396 2015
29
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 61
25533148 2014
30
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 61
25501172 2014
31
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 61
25108779 2014
32
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 61
24742108 2014
33
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 61
24218580 2013
34
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 61
23788593 2013
35
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 61
23363571 2013
36
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 61
23279233 2013
37
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 61
24155949 2013
38
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 61
23140893 2012
39
Gangrene in cases of spotted fever: a report of three cases. 61
23257640 2012
40
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 61
22541336 2012
41
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 61
22634883 2012
42
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 61
23101229 2012
43
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 61
22172164 2011
44
Rickettsia parkeri Rickettsiosis, Argentina. 61
21762568 2011
45
An acarologic survey and Amblyomma americanum distribution map with implications for tularemia risk in Missouri. 61
21363979 2011
46
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. 61
21291605 2011
47
Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia. 61
21340366 2011
48
Acute undifferentiated febrile illness in adult hospitalized patients: the disease spectrum and diagnostic predictors - an experience from a tertiary care hospital in South India. 61
20870680 2010
49
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 61
20233665 2010
50
Proteomic analysis of Rickettsia parkeri strain portsmouth. 61
19797064 2009
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Variations for Spotted Fever Rickettsiosis

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Expression for Spotted Fever Rickettsiosis

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Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.
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Pathways for Spotted Fever Rickettsiosis

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Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.13 TNF NOS2 IL10 IFNG CCL5
2
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 12.87 TNF NOS2 IL10 IFNG CCL5
3
Allograft rejection 36 1
Show member pathways
 12.66 TNF IL10 IFNG CTLA4
4
T cell receptor signaling pathway 36
Show member pathways
 12.43 TNF IL10 IFNG CTLA4
5
Immune response IL-23 signaling pathway 22
Show member pathways
 12.41 TNF NOS2 IL10 IFNG
6
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.16 TNF IL10 CCL5
7
Folate Metabolism 1
Show member pathways
 12.15 TNF IFNG CCL5
8
Toll Comparative Pathway 63
Show member pathways
 12.13 TNF NOS2 IFNG
9
Colorectal Cancer Metastasis 63
12.03 TNF NOS2 IFNG
10
Bacterial infections in CF airways 22
Show member pathways
 12.02 TNF NOS2 IFNG
11
Toxoplasmosis 36
Show member pathways
 12.01 TNF NOS2 IL10 IFNG
12
Tuberculosis 36
11.96 TNF NOS2 IL10 IFNG
13
NF-kappaB Signaling 4
11.95 TNF IL10 IFNG IDO1 CTLA4 CCL5
14
Th1 Differentiation Pathway 64
Show member pathways
 11.9 TNF IL10 IFNG
15
Spinal Cord Injury 1
11.86 TNF NOS2 IFNG
16
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.84 TNF IL10 IFNG
17
Interleukin-4 and 13 signaling 65
11.82 TNF NOS2 IL10
18
Innate Lymphoid Cell Differentiation Pathways 64
11.65 TNF IL10 IFNG
19
Amoebiasis 36
11.63 TNF NOS2 IL10 IFNG
20
Pertussis 36
11.61 TNF NOS2 IL10
21
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.6 TNF IFNG CTLA4
22
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF IL10 IFNG
23
Rheumatoid arthritis 36
11.53 TNF IFNG CTLA4 CCL5
24
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.49 TNF NOS2 IFNG
25
Malaria 36
11.37 TNF IL10 IFNG
26
Th2 Differentiation Pathway 64
11.34 IL10 IFNG
27
Interleukin-10 signaling 65
11.34 TNF IL10 CCL5
28
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.32 TNF IFNG
29
MSP-RON Signaling 63
11.31 TNF NOS2 IFNG
30
Type II interferon signaling (IFNG) 1
11.23 NOS2 IFNG
31
IL-10 Pathway 63
11.21 TNF IL10
32
Development and heterogeneity of the ILC family 1
11.16 TNF IFNG
33
OX40 Pathway 63
11.07 IL10 IFNG
34
EBV LMP1 signaling 1
11.02 TNF CCL5
35
African trypanosomiasis 36
11.02 TNF IL10 IFNG IDO1
36
Cytokines and Inflammatory Response 1
11.01 TNF IL10 IFNG
37
Microglia Activation During Neuroinflammation: Microglia Polarization 64
10.87 TNF NOS2 IL10 IFNG CCL5
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GO Terms for Spotted Fever Rickettsiosis

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Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.85 TNF NOS2 IFNG
2 defense response to bacterium GO:0042742 9.84 TNF NOS2 IL10
3 inflammatory response GO:0006954 9.84 TNF IL10 IDO1 CCL5
4 cellular response to lipopolysaccharide GO:0071222 9.81 TNF NOS2 IL10
5 response to lipopolysaccharide GO:0032496 9.81 NOS2 IL10 IDO1
6 cytokine-mediated signaling pathway GO:0019221 9.76 TNF NOS2 IL10 CCL5
7 response to virus GO:0009615 9.74 TNF IFNG CCL5
8 positive regulation of phagocytosis GO:0050766 9.7 TNF IFNG
9 interleukin-12-mediated signaling pathway GO:0035722 9.69 IL10 IFNG
10 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF IFNG
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 TNF IFNG
12 negative regulation of viral genome replication GO:0045071 9.68 TNF CCL5
13 positive regulation of protein complex assembly GO:0031334 9.68 TNF IFNG
14 protein kinase B signaling GO:0043491 9.68 TNF CCL5
15 negative regulation of mitotic cell cycle GO:0045930 9.68 TNF IL10
16 negative regulation of interleukin-6 production GO:0032715 9.67 TNF IL10
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF CCL5
18 regulation of synapse organization GO:0050807 9.66 TNF IL10
19 positive regulation of cytokine secretion GO:0050715 9.65 TNF IL10
20 microglial cell activation GO:0001774 9.65 TNF IFNG
21 positive regulation of interleukin-12 production GO:0032735 9.65 IFNG IDO1
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TNF IFNG CCL5
23 positive regulation of osteoclast differentiation GO:0045672 9.64 TNF IFNG
24 positive regulation of amyloid-beta formation GO:1902004 9.63 TNF IFNG
25 astrocyte activation GO:0048143 9.62 TNF IFNG
26 negative regulation of B cell proliferation GO:0030889 9.62 IL10 CTLA4
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 TNF IFNG
28 regulation of regulatory T cell differentiation GO:0045589 9.61 IFNG CTLA4
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 TNF IL10
30 positive regulation of chemokine biosynthetic process GO:0045080 9.59 TNF IFNG
31 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IFNG
33 negative regulation of T cell apoptotic process GO:0070233 9.56 IDO1 CCL5
34 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
35 immune response GO:0006955 9.55 TNF IL10 IFNG CTLA4 CCL5
36 negative regulation of T cell proliferation GO:0042130 9.54 IL10 IDO1 CTLA4
37 positive regulation of T cell apoptotic process GO:0070234 9.52 IDO1 CCL5
38 positive regulation of killing of cells of other organism GO:0051712 9.51 NOS2 IFNG
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 TNF IL10
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
41 receptor biosynthetic process GO:0032800 9.4 TNF IL10
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
43 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
44 positive regulation of JAK-STAT cascade GO:0046427 9.13 TNF IL10 CCL5
45 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5
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Sources for Spotted Fever Rickettsiosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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