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MCID: SPT024
MIFTS: 37

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Spotted Fever Rickettsiosis

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MalaCards integrated aliases for Spotted Fever Rickettsiosis:

Name: Spotted Fever Rickettsiosis 59
Spotted Fever Rickettsiae Disease 59

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 34 A77.0 A77.1 A77.2 more
Orphanet 59 ORPHA102022
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Summaries for Spotted Fever Rickettsiosis

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MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to exanthem and african tick-bite fever. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs carbamide peroxide and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

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Related Diseases for Spotted Fever Rickettsiosis

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Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.9 TNF CTLA4
2 african tick-bite fever 30.8 IFNG CCL5
3 chikungunya 30.5 TNF CCL5
4 typhoid fever 30.4 TNF IFNG
5 spotted fever 30.4 TNF IL10 IFNG CCL5
6 q fever 29.7 TNF IL10 IFNG
7 leptospirosis 29.7 TNF IL10 IFNG
8 chlamydia 28.0 TNF NOS2 IL10 IFNG IDO1
9 boutonneuse fever 10.5
10 rickettsial disease 10.5
11 rocky mountain spotted fever 10.4
12 scorpion envenomation 10.4 TNF CCL5
13 stachybotrys chartarum 10.4 TNF CCL5
14 folliculitis 10.4 IFNG CCL5
15 viral meningitis 10.3 IFNG CCL5
16 sympathetic ophthalmia 10.3 TNF CTLA4
17 eumycotic mycetoma 10.3 IFNG CCL5
18 inclusion conjunctivitis 10.3 TNF CCL5
19 urinary schistosomiasis 10.3 IFNG CTLA4
20 japanese encephalitis 10.3 TNF CCL5
21 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 IFNG CCL5
22 vulvovaginitis 10.3 IL10 CCL5
23 toxic oil syndrome 10.3 IFNG IDO1
24 listeriosis 10.3 TNF IDO1
25 epidemic typhus 10.3
26 autoimmune disease of endocrine system 10.3 IFNG CTLA4
27 staphylococcal toxic shock syndrome 10.3 TNF IFNG
28 autoimmune myocarditis 10.3 TNF IFNG
29 autoimmune disease of gastrointestinal tract 10.3 IFNG CTLA4
30 chronic beryllium disease 10.2 TNF IFNG
31 trichosporonosis 10.2 TNF IFNG
32 griscelli syndrome, type 2 10.2 IL10 CCL5
33 scleritis 10.2 TNF IFNG
34 griscelli syndrome 10.2 IL10 CCL5
35 miliary tuberculosis 10.2 TNF IFNG
36 microscopic colitis 10.2 TNF IFNG
37 genital herpes 10.2 IL10 CCL5
38 central nervous system vasculitis 10.2 TNF IFNG
39 meconium aspiration syndrome 10.2 TNF IFNG
40 soft tissue sarcoma 10.2 TNF IFNG
41 tuberculous peritonitis 10.2 TNF IFNG
42 posterior uveitis 10.2 TNF IFNG
43 cytomegalovirus retinitis 10.2 TNF IFNG
44 lichen disease 10.2 TNF IFNG
45 pleural tuberculosis 10.2 TNF IFNG
46 erythema multiforme 10.2 TNF IFNG
47 punctate inner choroidopathy 10.2 TNF IL10
48 tropical endomyocardial fibrosis 10.2 TNF IL10
49 endomyocardial fibrosis 10.2 TNF IL10
50 cephalosporin allergy 10.2 IL10 IFNG

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis
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Symptoms & Phenotypes for Spotted Fever Rickettsiosis

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MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
2 cardiovascular system MP:0005385 9.99 CTLA4 IDO1 IFNG IL10 NOS2 TNF
3 immune system MP:0005387 9.98 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.89 CTLA4 IFNG IL10 NOS2 TNF
5 endocrine/exocrine gland MP:0005379 9.88 CTLA4 IFNG IL10 NOS2 TNF
6 integument MP:0010771 9.8 CTLA4 IFNG IL10 NOS2 TNF
7 liver/biliary system MP:0005370 9.77 CTLA4 IFNG IL10 NOS2 TNF
8 muscle MP:0005369 9.72 IDO1 IFNG IL10 NOS2 TNF
9 neoplasm MP:0002006 9.56 IFNG IL10 NOS2 TNF
10 reproductive system MP:0005389 9.55 IDO1 IFNG IL10 NOS2 TNF
11 respiratory system MP:0005388 9.35 CTLA4 IFNG IL10 NOS2 TNF
12 skeleton MP:0005390 9.02 CTLA4 IFNG IL10 NOS2 TNF
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Drugs & Therapeutics for Spotted Fever Rickettsiosis

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Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

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Genetic Tests for Spotted Fever Rickettsiosis

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Anatomical Context for Spotted Fever Rickettsiosis

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MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

41
Testes, Skin, Endothelial
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Publications for Spotted Fever Rickettsiosis

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Articles related to Spotted Fever Rickettsiosis:

(show top 50) (show all 82)
# Title Authors PMID Year
1
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 38
31134290 2019
2
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 38
31097370 2019
3
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 38
31202622 2019
4
Antibody titers reactive with Rickettsia rickettsii in blood donors and implications for surveillance of spotted fever rickettsiosis in the United States. 38
31267128 2019
5
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 38
31331735 2019
6
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 38
31216274 2019
7
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 38
30969821 2019
8
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 38
31084685 2019
9
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 38
30771038 2019
10
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 38
30315767 2019
11
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 38
30635303 2019
12
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 38
30197269 2019
13
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 38
30618452 2018
14
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 38
30274426 2018
15
Fatal spotted fever rickettsiosis in Argentina. 38
29942776 2018
16
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 38
28764157 2017
17
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 38
28576950 2017
18
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 38
28806774 2017
19
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 38
27508322 2016
20
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 38
27318438 2016
21
A Clinical Review of Tick-Borne Diseases in Arkansas. 38
27263175 2016
22
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 38
26432518 2015
23
Spotted fever rickettsiosis in Uttar Pradesh. 38
25900962 2015
24
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 38
26394396 2015
25
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 38
25590681 2015
26
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 38
25533148 2014
27
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 38
25501172 2014
28
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 38
25108779 2014
29
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 38
24742108 2014
30
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 38
24218580 2013
31
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 38
23788593 2013
32
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 38
23363571 2013
33
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 38
23279233 2013
34
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 38
24155949 2013
35
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 38
23140893 2012
36
Gangrene in cases of spotted fever: a report of three cases. 38
23257640 2012
37
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 38
22541336 2012
38
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 38
22634883 2012
39
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 38
23101229 2012
40
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 38
22172164 2011
41
Rickettsia parkeri Rickettsiosis, Argentina. 38
21762568 2011
42
An acarologic survey and Amblyomma americanum distribution map with implications for tularemia risk in Missouri. 38
21363979 2011
43
Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia. 38
21340366 2011
44
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. 38
21291605 2011
45
Acute undifferentiated febrile illness in adult hospitalized patients: the disease spectrum and diagnostic predictors - an experience from a tertiary care hospital in South India. 38
20870680 2010
46
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 38
20233665 2010
47
Proteomic analysis of Rickettsia parkeri strain portsmouth. 38
19797064 2009
48
Spotted fever rickettsiosis infection in a traveler from Sri Lanka. 38
19930388 2009
49
Rickettsia slovaca and Rickettsia raoultii in Dermacentor marginatus ticks collected on wild boars in Tuscany, Italy. 38
19960702 2009
50
CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis. 38
19564386 2009
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Variations for Spotted Fever Rickettsiosis

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Expression for Spotted Fever Rickettsiosis

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Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.
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Pathways for Spotted Fever Rickettsiosis

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Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.75 TNF NOS2 IL10 IFNG CTLA4 CCL5
2
PEDF Induced Signaling 64
Show member pathways
 13.43 TNF NOS2 IL10 IFNG CCL5
3
Cytokine Signaling in Immune system 66
Show member pathways
 13.12 TNF NOS2 IL10 IFNG CCL5
4
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.84 TNF NOS2 IL10 IFNG CCL5
5
Allograft rejection 37 1
Show member pathways
 12.67 TNF IL10 IFNG CTLA4
6
Immune response IL-23 signaling pathway 22
Show member pathways
 12.41 TNF NOS2 IL10 IFNG
7
Th17 cell differentiation 37
Show member pathways
 12.4 TNF IL10 IFNG
8
T cell receptor signaling pathway 37
Show member pathways
 12.37 TNF IL10 IFNG CTLA4
9
Selenium Micronutrient Network 1
Show member pathways
 12.16 TNF IFNG CCL5
10
Toll Comparative Pathway 64
Show member pathways
 12.13 TNF NOS2 IFNG
11
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.07 TNF IL10 IFNG
12
Colorectal Cancer Metastasis 64
12.02 TNF NOS2 IFNG
13
Bacterial infections in CF airways 22
Show member pathways
 12.02 TNF NOS2 IFNG
14
Toxoplasmosis 37
Show member pathways
 12.01 TNF NOS2 IL10 IFNG
15
Tuberculosis 37
11.96 TNF NOS2 IL10 IFNG
16
NF-kappaB Signaling 4
11.95 TNF IL10 IFNG IDO1 CTLA4 CCL5
17
Th1 Differentiation Pathway 65
Show member pathways
 11.9 TNF IL10 IFNG
18
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.89 IL10 IFNG CCL5
19
Spinal Cord Injury 1
11.86 TNF NOS2 IFNG
20
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.84 TNF IL10 IFNG
21
Interleukin-4 and 13 signaling 66
11.82 TNF NOS2 IL10
22
Innate Lymphoid Cell Differentiation Pathways 65
11.66 TNF IL10 IFNG
23
Amoebiasis 37
11.63 TNF NOS2 IL10 IFNG
24
Pertussis 37
11.62 TNF NOS2 IL10
25
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.61 TNF IFNG CTLA4
26
Dendritic Cells Developmental Lineage Pathway 65
11.59 TNF IL10 IFNG
27
Rheumatoid arthritis 37
11.53 TNF IFNG CTLA4 CCL5
28
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.51 TNF NOS2 IFNG
29
ATF-2 transcription factor network 1
11.44 NOS2 IFNG
30
Photodynamic therapy-induced AP-1 survival signaling. 1
11.4 TNF IFNG
31
Cellular Transformation by HTLV1 64
Show member pathways
 11.38 TNF IFNG
32
Aryl Hydrocarbon Receptor Pathway 1
11.36 TNF IFNG
33
Malaria 37
11.36 TNF IL10 IFNG
34
Th2 Differentiation Pathway 65
11.34 IL10 IFNG
35
Interleukin-10 signaling 66
11.34 TNF IL10 CCL5
36
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.32 TNF IFNG
37
MSP-RON Signaling 64
11.31 TNF NOS2 IFNG
38
Type II interferon signaling (IFNG) 1
11.23 NOS2 IFNG
39
IL-10 Pathway 64
11.21 TNF IL10
40
Development and heterogeneity of the ILC family 1
11.16 TNF IFNG
41
OX40 Pathway 64
11.07 IL10 IFNG
42
G-protein signaling_RhoB regulation pathway 22
11.04 TNF IL10 CCL5
43
EBV LMP1 signaling 1
11.02 TNF CCL5
44
African trypanosomiasis 37
11.02 TNF IL10 IFNG IDO1
45
Cytokines and Inflammatory Response 1
11.01 TNF IL10 IFNG
46
Microglia Activation During Neuroinflammation: Microglia Polarization 65
10.87 TNF NOS2 IL10 IFNG CCL5
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GO Terms for Spotted Fever Rickettsiosis

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Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.85 TNF IDO1 CTLA4
2 negative regulation of gene expression GO:0010629 9.82 TNF NOS2 IFNG
3 defense response to bacterium GO:0042742 9.81 TNF NOS2 IL10
4 inflammatory response GO:0006954 9.8 TNF IL10 IDO1 CCL5
5 response to lipopolysaccharide GO:0032496 9.77 NOS2 IL10 IDO1
6 cellular response to lipopolysaccharide GO:0071222 9.77 TNF NOS2 IL10
7 cytokine-mediated signaling pathway GO:0019221 9.73 TNF NOS2 IL10 CCL5
8 response to virus GO:0009615 9.71 TNF IFNG CCL5
9 positive regulation of protein localization to plasma membrane GO:1903078 9.68 TNF IFNG
10 positive regulation of cell adhesion GO:0045785 9.68 TNF CCL5
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.67 TNF IL10
12 interleukin-12-mediated signaling pathway GO:0035722 9.67 IL10 IFNG
13 extrinsic apoptotic signaling pathway GO:0097191 9.67 TNF IFNG
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.66 TNF IFNG
15 negative regulation of viral genome replication GO:0045071 9.66 TNF CCL5
16 protein kinase B signaling GO:0043491 9.65 TNF CCL5
17 negative regulation of mitotic cell cycle GO:0045930 9.65 TNF IL10
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF CCL5
19 negative regulation of interleukin-6 production GO:0032715 9.63 TNF IL10
20 regulation of synapse organization GO:0050807 9.63 TNF IL10
21 positive regulation of cytokine secretion GO:0050715 9.62 TNF IL10
22 positive regulation of protein complex assembly GO:0031334 9.62 TNF IFNG
23 positive regulation of interleukin-12 production GO:0032735 9.61 IFNG IDO1
24 positive regulation of osteoclast differentiation GO:0045672 9.61 TNF IFNG
25 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG CTLA4
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IFNG
27 negative regulation of B cell proliferation GO:0030889 9.57 IL10 CTLA4
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 TNF IL10
29 negative regulation of growth of symbiont in host GO:0044130 9.55 TNF IL10
30 negative regulation of T cell apoptotic process GO:0070233 9.52 IDO1 CCL5
31 endothelial cell apoptotic process GO:0072577 9.51 TNF IL10
32 positive regulation of T cell apoptotic process GO:0070234 9.48 IDO1 CCL5
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 TNF IL10
34 negative regulation of T cell proliferation GO:0042130 9.43 IL10 IDO1 CTLA4
35 positive regulation of killing of cells of other organism GO:0051712 9.4 NOS2 IFNG
36 receptor biosynthetic process GO:0032800 9.37 TNF IL10
37 immune response GO:0006955 9.35 TNF IL10 IFNG CTLA4 CCL5
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IFNG
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 TNF IFNG
40 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5
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Sources for Spotted Fever Rickettsiosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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