MCID: SPT024
MIFTS: 37

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Spotted Fever Rickettsiosis

MalaCards integrated aliases for Spotted Fever Rickettsiosis:

Name: Spotted Fever Rickettsiosis 58
Spotted Fever Rickettsiae Disease 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A77.0 A77.1 A77.2 more
Orphanet 58 ORPHA102022

Summaries for Spotted Fever Rickettsiosis

MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to exanthem and leptospirosis. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs carbamide peroxide and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and eye, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Spotted Fever Rickettsiosis

Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 367, show less)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.2 TNF IL10 CTLA4
2 leptospirosis 29.7 TNF IL10 IFNG
3 spotted fever 29.5 TNF IL10 IFNG IDO1 CTLA4 CCL5
4 african tick-bite fever 29.3 TNF IL10 IFNG CCL5
5 q fever 29.3 TNF IL10 IFNG CCL5
6 thrombocytopenia 29.2 TNF IL10 IFNG CTLA4
7 immune deficiency disease 28.8 TNF IL10 IFNG IDO1 CCL5
8 chlamydia 28.3 TNF NOS2 IL10 IFNG IDO1
9 boutonneuse fever 10.5
10 rickettsial disease 10.5
11 rocky mountain spotted fever 10.4
12 epidemic typhus 10.3
13 typhoid fever 10.3
14 scorpion envenomation 10.3 TNF CCL5
15 stachybotrys chartarum 10.2 TNF CCL5
16 microscopic polyangiitis 10.2 TNF CTLA4
17 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 IFNG CCL5
18 skin sarcoidosis 10.2 TNF CTLA4
19 autoimmune disease of cardiovascular system 10.2 TNF CTLA4
20 toxic oil syndrome 10.2 IFNG IDO1
21 urinary schistosomiasis 10.1 IFNG CTLA4
22 folliculitis 10.1 IFNG CCL5
23 eosinophilia-myalgia syndrome 10.1 IFNG IDO1
24 polyarticular juvenile idiopathic arthritis 10.1 TNF IFNG
25 staphylococcal toxic shock syndrome 10.1 TNF IFNG
26 autoimmune myocarditis 10.1 TNF IFNG
27 branchiootic syndrome 1 10.1
28 cyanosis, transient neonatal 10.1
29 chikungunya 10.1
30 endemic typhus 10.1
31 visual epilepsy 10.1
32 neutropenia 10.1
33 47,xyy 10.1
34 splenomegaly 10.1
35 febrile seizures 10.1
36 seizure disorder 10.1
37 tremor 10.1
38 vulvovaginitis 10.1 IL10 CCL5
39 chronic beryllium disease 10.1 TNF IFNG
40 eczema herpeticum 10.1 IFNG IDO1
41 soft tissue sarcoma 10.1 TNF IFNG
42 gastrointestinal tuberculosis 10.1 TNF IFNG
43 bone sarcoma 10.1 IL10 CTLA4
44 intestinal tuberculosis 10.1 TNF IFNG
45 oral tuberculosis 10.1 TNF IFNG
46 inflammatory bowel disease 18 10.1 IL10 CTLA4
47 abdominal tuberculosis 10.1 TNF IFNG
48 myelitis 10.1 TNF IL10
49 lung abscess 10.1 TNF IFNG
50 miliary tuberculosis 10.1 TNF IFNG
51 paratyphoid fever 10.1 TNF IFNG
52 punctate inner choroidopathy 10.1 TNF IL10
53 cardiac sarcoidosis 10.1 TNF IFNG
54 viral meningitis 10.1 IFNG CCL5
55 scleritis 10.1 TNF IFNG
56 tropical endomyocardial fibrosis 10.1 TNF IL10
57 endomyocardial fibrosis 10.1 TNF IL10
58 status asthmaticus 10.1 IL10 CCL5
59 spastic paraparesis 10.1 IL10 IFNG
60 meconium aspiration syndrome 10.1 TNF IFNG
61 latex allergy 10.1 TNF IFNG
62 microscopic colitis 10.1 TNF IFNG
63 genital herpes 10.0 IL10 CCL5
64 pleural tuberculosis 10.0 TNF IFNG
65 multifocal choroiditis 10.0 TNF IL10
66 palladium allergic contact dermatitis 10.0 TNF IL10
67 radiculopathy 10.0 IL10 CCL5
68 autoimmune disease of blood 10.0 IL10 CTLA4
69 lichen disease 10.0 TNF IFNG
70 chronic graft versus host disease 10.0 IL10 IFNG
71 histoplasmosis 10.0 TNF IFNG
72 nickel allergic contact dermatitis 10.0 IL10 IFNG
73 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.0 IL10 CTLA4
74 combined thymoma 10.0 TNF IL10
75 post-transplant lymphoproliferative disease 10.0 TNF IL10
76 transient hypogammaglobulinemia 10.0 TNF IL10
77 transverse myelitis 10.0 TNF IL10
78 chemical colitis 10.0 TNF IL10
79 primary peritoneal carcinoma 10.0 IL10 IFNG
80 buruli ulcer 10.0 IL10 IFNG
81 chlamydia pneumonia 10.0 TNF IL10
82 japanese encephalitis 10.0 TNF CCL5
83 epstein-barr virus-associated gastric carcinoma 10.0 TNF IL10
84 tuberculoid leprosy 10.0 IL10 IFNG
85 hidradenitis 10.0 TNF IFNG
86 orchitis 10.0 TNF IL10
87 chronic conjunctivitis 10.0 TNF IL10
88 hidradenitis suppurativa 10.0 TNF IFNG
89 cow milk allergy 10.0 TNF IL10
90 milk allergy 10.0 TNF IL10
91 penicillin allergy 10.0 IL10 IFNG
92 trichuriasis 10.0 TNF IL10
93 bronchopneumonia 10.0 TNF IL10
94 relapsing polychondritis 10.0 IL10 IFNG
95 cystic echinococcosis 10.0 IL10 IFNG
96 drug-induced lupus erythematosus 10.0 TNF IL10
97 endometrial disease 10.0 TNF IL10
98 streptococcus pneumonia 10.0 TNF IL10
99 fascioliasis 10.0 IL10 IFNG
100 multicentric castleman disease 10.0 IL10 IFNG
101 cyclic neutropenia 10.0 TNF IFNG
102 pellagra 9.9 IL10 IDO1
103 lacrimal apparatus disease 9.9 TNF IL10
104 posterior uveitis 9.9 TNF IFNG
105 periapical granuloma 9.9 NOS2 CCL5
106 gingival disease 9.9 TNF IL10
107 panuveitis 9.9 TNF IL10
108 herpangina 9.9 TNF IL10
109 perinatal necrotizing enterocolitis 9.9 TNF IL10
110 exocrine pancreatic insufficiency 9.9 TNF CTLA4
111 peanut allergy 9.9 IL10 IFNG
112 graves' disease 9.9 IFNG CTLA4 CCL5
113 dystrophinopathies 9.9 TNF NOS2
114 ige responsiveness, atopic 9.9 IL10 IFNG
115 erythema multiforme 9.9 TNF IFNG CCL5
116 hand, foot and mouth disease 9.9 IL10 IFNG
117 tympanosclerosis 9.9 TNF NOS2
118 middle ear disease 9.9 TNF IL10
119 keratoconjunctivitis 9.9 TNF IFNG CCL5
120 alopecia 9.9 TNF IFNG CTLA4
121 pulmonary sarcoidosis 9.8 TNF IFNG CCL5
122 central nervous system vasculitis 9.8 TNF IFNG CTLA4
123 arthus reaction 9.8 TNF NOS2
124 allergic bronchopulmonary aspergillosis 9.8 IL10 IFNG
125 dysentery 9.8 TNF IL10
126 sarcoidosis 1 9.8 TNF IFNG CCL5
127 measles 9.8 TNF IFNG CCL5
128 lambert-eaton myasthenic syndrome 9.8 TNF IL10
129 idiopathic neutropenia 9.8 TNF IL10 CCL5
130 viral pneumonia 9.8 TNF IL10 CCL5
131 pulpitis 9.8 TNF NOS2
132 chronic inflammatory demyelinating polyradiculoneuropathy 9.8 IL10 IFNG CCL5
133 vaginitis 9.8 TNF IL10 CCL5
134 polyradiculoneuropathy 9.8 IL10 IFNG CCL5
135 dermatitis herpetiformis 9.8 TNF IL10
136 vaginal disease 9.8 TNF IL10 CCL5
137 conjunctival disease 9.8 TNF IL10 CCL5
138 viral encephalitis 9.8 TNF IL10 CCL5
139 diabetic polyneuropathy 9.8 TNF NOS2
140 meningoencephalitis 9.8 TNF IL10 CCL5
141 common cold 9.8 TNF IL10 CCL5
142 ileitis 9.8 TNF IL10 CCL5
143 respiratory allergy 9.8 TNF IL10 CCL5
144 tropical spastic paraparesis 9.8 IL10 IFNG CCL5
145 hepatopulmonary syndrome 9.8 TNF NOS2
146 anus disease 9.8 TNF IL10
147 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 IL10 IFNG CTLA4
148 lymphopenia 9.8 IL10 IFNG CTLA4
149 esophagitis 9.8 TNF IL10 CCL5
150 thyroiditis 9.8 TNF IL10 CTLA4
151 autoimmune disease of eyes, ear, nose and throat 9.8 TNF IL10 CTLA4
152 sympathetic ophthalmia 9.8 TNF IL10 CTLA4
153 takayasu arteritis 9.8 TNF IL10 CCL5
154 autoimmune disease of urogenital tract 9.8 TNF IL10 CTLA4
155 autoimmune pancreatitis 9.8 TNF IL10 CTLA4
156 churg-strauss syndrome 9.8 TNF IL10
157 bronchitis 9.8 TNF IL10 CCL5
158 chronic granulomatous disease 9.8 TNF IFNG IDO1
159 spinal cord injury 9.8 TNF NOS2
160 pertussis 9.8 TNF IL10 CCL5
161 hypereosinophilic syndrome 9.7 IL10 IFNG CCL5
162 extrinsic cardiomyopathy 9.7 TNF IL10 CTLA4
163 primary progressive multiple sclerosis 9.7 TNF IL10 CTLA4
164 hepatitis b 9.7 TNF IFNG CTLA4
165 hair disease 9.7 TNF IL10 CTLA4
166 periventricular leukomalacia 9.7 TNF NOS2
167 allergic rhinitis 9.7 IL10 IFNG CCL5
168 sezary's disease 9.7 IL10 IFNG CTLA4
169 autoimmune hepatitis 9.7 TNF IL10 CTLA4
170 cholangitis 9.7 TNF IL10 CTLA4
171 trachoma 9.7 TNF IL10 IDO1
172 listeriosis 9.7 TNF IL10 IDO1
173 arteriosclerosis 9.7 IL10 IFNG CCL5
174 leukocyte disease 9.7 TNF IL10 CTLA4
175 autoimmune lymphoproliferative syndrome 9.7 TNF IL10 CTLA4
176 blau syndrome 9.7 TNF IL10
177 pulmonary disease, chronic obstructive 9.7 TNF IL10 CCL5
178 bacterial infectious disease 9.7 TNF IL10 IFNG
179 sporotrichosis 9.7 TNF IL10 IFNG
180 clonorchiasis 9.7 TNF IL10 IFNG
181 mucocutaneous leishmaniasis 9.7 TNF IL10 IFNG
182 chorioretinitis 9.7 TNF IL10 IFNG
183 choroiditis 9.7 TNF IL10 IFNG
184 fungal meningitis 9.7 TNF IL10 IFNG
185 macs syndrome 9.7 TNF IL10 IFNG
186 acute graft versus host disease 9.7 TNF IL10 IFNG
187 primary systemic mycosis 9.7 TNF IL10 IFNG
188 cytomegalovirus retinitis 9.7 TNF IL10 IFNG
189 multidrug-resistant tuberculosis 9.7 TNF IL10 IFNG
190 autoimmune gastritis 9.7 TNF IL10 IFNG
191 intermediate uveitis 9.7 TNF IL10 IFNG
192 poliomyelitis 9.7 TNF IL10 IFNG
193 cryptococcosis 9.7 TNF IL10 IFNG
194 chickenpox 9.7 TNF IL10 IFNG
195 mycoplasma pneumoniae pneumonia 9.7 TNF IL10 IFNG
196 echinococcosis 9.7 TNF IL10 IFNG
197 coccidiosis 9.7 TNF IL10 IFNG
198 subacute sclerosing panencephalitis 9.7 TNF IL10 IFNG
199 extrapulmonary tuberculosis 9.7 TNF IL10 IFNG
200 pulmonary tuberculosis 9.7 TNF IL10 IFNG
201 aseptic meningitis 9.7 TNF IL10 IFNG
202 plasmodium vivax malaria 9.7 TNF IL10 IFNG
203 cutaneous lupus erythematosus 9.7 TNF IL10 IFNG
204 rheumatic fever 9.7 TNF IL10 IFNG
205 rectal disease 9.7 TNF IL10
206 opportunistic mycosis 9.7 TNF IL10 IFNG
207 paranasal sinus disease 9.7 TNF IL10 IFNG
208 allergic conjunctivitis 9.7 TNF IL10 IFNG
209 conjunctivitis 9.7 TNF IL10 IFNG
210 autoimmune uveitis 9.7 TNF IL10 IFNG
211 cryoglobulinemia 9.7 TNF IL10 IFNG
212 lymph node disease 9.7 TNF IL10 IFNG
213 aphthous stomatitis 9.7 TNF IL10 IFNG
214 stomatitis 9.7 TNF IL10 IFNG
215 mixed connective tissue disease 9.7 TNF IL10 IFNG
216 respiratory failure 9.7 TNF IL10 CCL5
217 herpes zoster 9.7 TNF IL10 IFNG
218 appendicitis 9.7 TNF IL10 IFNG
219 melioidosis 9.7 TNF IL10 IFNG
220 graft-versus-host disease 9.7 TNF IL10 IFNG
221 commensal bacterial infectious disease 9.7 TNF IL10 IFNG
222 brucellosis 9.7 TNF IL10 IFNG
223 tonsillitis 9.7 TNF IL10 IFNG
224 parasitic helminthiasis infectious disease 9.7 TNF IL10 IFNG
225 dengue hemorrhagic fever 9.7 TNF IL10 IFNG
226 spondylitis 9.7 TNF IL10 IFNG
227 allergic contact dermatitis 9.7 TNF IL10 IFNG
228 contact dermatitis 9.7 TNF IL10 IFNG
229 ileus 9.7 TNF IL10 IFNG
230 salmonellosis 9.7 TNF IL10 IFNG
231 testicular disease 9.7 TNF IL10 IFNG
232 bacterial meningitis 9.7 TNF IL10 IFNG
233 mumps 9.7 TNF IL10 IFNG
234 leprosy 3 9.7 TNF IL10 IFNG
235 lymphadenitis 9.7 TNF IL10 IFNG
236 reactive arthritis 9.7 TNF IL10 IFNG
237 neuromuscular disease 9.7 TNF IL10 CTLA4
238 lichen planus 9.7 TNF IL10 IFNG
239 rubella 9.7 TNF IL10 IFNG
240 spondyloarthropathy 9.7 TNF IL10 IFNG
241 endocarditis 9.7 TNF IL10 IFNG
242 parasitic protozoa infectious disease 9.6 TNF IL10 IFNG
243 gastroenteritis 9.6 TNF IL10 IFNG
244 otitis media 9.6 TNF IL10 IFNG
245 periodontitis 9.6 TNF IL10 IFNG
246 chronic mucocutaneous candidiasis 9.6 TNF IL10 IFNG
247 candidiasis 9.6 TNF IL10 IFNG
248 omenn syndrome 9.6 TNF IL10 IFNG
249 viral hepatitis 9.6 TNF IL10 IFNG
250 upper respiratory tract disease 9.6 TNF IL10 IFNG
251 tetanus 9.6 TNF IL10 IFNG
252 rheumatic disease 9.6 TNF IL10 IFNG
253 invasive aspergillosis 9.6 IL10 IFNG
254 pleurisy 9.6 TNF IFNG
255 crohn's disease 9.6 TNF IL10 IFNG
256 mycobacterium tuberculosis 1 9.6 TNF IL10 IFNG
257 diarrhea 9.6 TNF IL10 IFNG
258 ulcerative colitis 9.6 TNF IL10 IFNG
259 mycetoma 9.6 NOS2 IL10 CCL5
260 hepatitis c 9.6 TNF IL10 IFNG
261 temporal arteritis 9.6 TNF IFNG CTLA4 CCL5
262 hydrocephalus 9.5 TNF IL10 IFNG
263 nervous system disease 9.5 TNF NOS2 IFNG
264 crohn's colitis 9.5 TNF NOS2 IFNG
265 griscelli syndrome, type 2 9.5 IL10 CCL5
266 influenza 9.5 TNF IFNG IDO1 CCL5
267 allergic asthma 9.5 IL10 IFNG CTLA4 CCL5
268 bacterial sepsis 9.4 TNF NOS2 IL10
269 chronic active epstein-barr virus infection 9.4 IL10 IFNG IDO1 CTLA4
270 central nervous system disease 9.4 TNF NOS2 IFNG
271 pulmonary edema 9.4 TNF NOS2 IL10
272 orofacial granulomatosis 9.4 TNF IL10 IFNG CCL5
273 nasal cavity disease 9.4 TNF IL10 IFNG CCL5
274 nose disease 9.4 TNF IL10 IFNG CCL5
275 bronchiolitis 9.4 TNF IL10 IFNG CCL5
276 pyelonephritis 9.4 TNF IL10 IFNG CCL5
277 severe acute respiratory syndrome 9.4 TNF IL10 IFNG CCL5
278 gingivitis 9.4 TNF IL10 IFNG CCL5
279 neuritis 9.4 TNF IL10 IFNG CCL5
280 osteomyelitis 9.4 TNF IL10 IFNG CCL5
281 chronic fatigue syndrome 9.4 TNF IL10 IFNG CCL5
282 bronchial disease 9.4 TNF IL10 IFNG CCL5
283 aspergillosis 9.4 TNF IL10 IFNG CCL5
284 relapsing-remitting multiple sclerosis 9.4 TNF IL10 IFNG CCL5
285 meningitis 9.4 TNF IL10 IFNG CCL5
286 rhinitis 9.4 TNF IL10 IFNG CCL5
287 interstitial lung disease 9.4 TNF IL10 IFNG CCL5
288 lung disease 9.4 TNF IL10 IFNG CCL5
289 pneumonia 9.4 TNF IL10 IFNG CCL5
290 paracoccidioidomycosis 9.4 TNF IL10 IFNG CTLA4
291 autoimmune disease of endocrine system 9.4 TNF IL10 IFNG CTLA4
292 autoimmune disease of gastrointestinal tract 9.4 TNF IL10 IFNG CTLA4
293 hypersensitivity reaction type iv disease 9.4 TNF IL10 IFNG CTLA4
294 bronchiolitis obliterans 9.4 TNF IL10 IFNG CTLA4
295 hepatitis a 9.4 TNF IL10 IFNG CTLA4
296 uveal disease 9.4 TNF IL10 IFNG CTLA4
297 hemophagocytic lymphohistiocytosis 9.4 TNF IL10 IFNG CTLA4
298 lymphatic system disease 9.4 TNF IL10 IFNG CTLA4
299 food allergy 9.4 TNF IL10 IFNG CTLA4
300 autoimmune disease of musculoskeletal system 9.4 TNF IL10 IFNG CTLA4
301 juvenile rheumatoid arthritis 9.4 TNF IL10 IFNG CTLA4
302 myasthenia gravis 9.4 TNF IL10 IFNG CTLA4
303 alopecia areata 9.4 TNF IL10 IFNG CTLA4
304 bone inflammation disease 9.4 TNF IL10 IFNG CTLA4
305 uveitis 9.4 TNF IL10 IFNG CTLA4
306 pulmonary fibrosis, idiopathic 9.4 TNF IL10 IFNG CCL5
307 hashimoto thyroiditis 9.4 TNF IL10 IFNG CTLA4
308 psoriatic arthritis 9.4 TNF IL10 IFNG CTLA4
309 peripheral nervous system disease 9.4 TNF IL10 IFNG CTLA4
310 behcet syndrome 9.4 TNF IL10 IFNG CTLA4
311 celiac disease 1 9.4 TNF IL10 IFNG CTLA4
312 common variable immunodeficiency 9.4 TNF IL10 IFNG CTLA4
313 lupus erythematosus 9.4 TNF IL10 IFNG CTLA4
314 connective tissue disease 9.4 TNF IL10 IFNG CTLA4
315 eye disease 9.4 TNF IL10 IFNG CCL5
316 scrub typhus 9.3 TNF IL10 IFNG IDO1
317 lepromatous leprosy 9.3 TNF IL10 IFNG IDO1
318 primary biliary cirrhosis 9.3 TNF IL10 IFNG CTLA4
319 aplastic anemia 9.3 TNF IL10 IFNG CTLA4
320 myeloma, multiple 9.3 TNF IL10 IFNG CTLA4
321 skin disease 9.3 TNF IL10 IFNG CTLA4
322 cervical cancer 9.3 TNF IL10 IFNG CTLA4
323 kidney disease 9.3 TNF NOS2 CTLA4 CCL5
324 gastritis 9.2 TNF NOS2 IL10 CCL5
325 myocardial infarction 9.2 TNF IL10 IFNG CCL5
326 schistosomiasis 9.1 TNF IL10 IFNG CTLA4 CCL5
327 primary bacterial infectious disease 9.1 TNF IL10 IFNG CTLA4 CCL5
328 autoimmune disease of central nervous system 9.1 TNF IL10 IFNG CTLA4 CCL5
329 immune system disease 9.1 TNF IL10 IFNG CTLA4 CCL5
330 demyelinating disease 9.1 TNF IL10 IFNG CTLA4 CCL5
331 allergic hypersensitivity disease 9.1 TNF IL10 IFNG CTLA4 CCL5
332 viral infectious disease 9.1 TNF IL10 IFNG CTLA4 CCL5
333 dermatitis 9.1 TNF IL10 IFNG CTLA4 CCL5
334 arthritis 9.1 TNF IL10 IFNG CTLA4 CCL5
335 dermatitis, atopic 9.1 TNF IL10 IFNG CTLA4 CCL5
336 psoriasis 9.1 TNF IL10 IFNG CTLA4 CCL5
337 eales disease 9.1 TNF NOS2 IL10 IFNG
338 splenic disease 9.1 TNF NOS2 IL10 IFNG
339 visceral leishmaniasis 9.1 TNF NOS2 IL10 IFNG
340 pre-eclampsia 9.1 TNF NOS2 IL10 IDO1
341 human immunodeficiency virus infectious disease 9.1 TNF IL10 IFNG IDO1 CCL5
342 plasmodium falciparum malaria 9.1 TNF NOS2 IL10 IFNG
343 toxic shock syndrome 9.1 TNF NOS2 IL10 IFNG
344 human immunodeficiency virus type 1 9.1 TNF IL10 IFNG IDO1 CCL5
345 acquired immunodeficiency syndrome 9.1 TNF NOS2 IL10 IFNG
346 systemic lupus erythematosus 9.0 TNF IL10 IFNG CTLA4 CCL5
347 vascular disease 9.0 TNF NOS2 IL10 IFNG
348 encephalitis 8.8 TNF NOS2 IL10 IDO1 CCL5
349 proteasome-associated autoinflammatory syndrome 1 8.8 TNF NOS2 IL10 IFNG CCL5
350 peritonitis 8.8 TNF NOS2 IL10 IFNG CCL5
351 cutaneous leishmaniasis 8.8 TNF NOS2 IL10 IFNG CTLA4
352 leishmaniasis 8.8 TNF NOS2 IL10 IFNG CTLA4
353 myocarditis 8.8 TNF NOS2 IL10 IFNG CTLA4
354 colitis 8.8 TNF NOS2 IL10 IFNG CTLA4
355 autoimmune disease 8.8 TNF IL10 IFNG IDO1 CTLA4 CCL5
356 diabetes mellitus, insulin-dependent 8.8 TNF NOS2 IL10 IFNG CTLA4
357 hypertension, essential 8.7 TNF NOS2 IL10 IFNG CCL5
358 toxoplasmosis 8.7 TNF NOS2 IL10 IFNG IDO1
359 dilated cardiomyopathy 8.7 TNF NOS2 IL10 IFNG CTLA4
360 filariasis 8.5 TNF NOS2 IL10 IFNG CTLA4 CCL5
361 chagas disease 8.5 TNF NOS2 IL10 IFNG CTLA4 CCL5
362 rheumatoid arthritis 8.5 TNF NOS2 IL10 IFNG CTLA4 CCL5
363 asthma 8.5 TNF NOS2 IL10 IFNG CTLA4 CCL5
364 trypanosomiasis 8.4 TNF NOS2 IL10 IFNG IDO1 CCL5
365 multiple sclerosis 8.1 TNF NOS2 IL10 IFNG IDO1 CTLA4
366 inflammatory bowel disease 8.1 TNF NOS2 IL10 IFNG IDO1 CTLA4
367 malaria 8.1 TNF NOS2 IL10 IFNG IDO1 CTLA4

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis

Symptoms & Phenotypes for Spotted Fever Rickettsiosis

MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

45 (showing 8, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.91 CTLA4 IDO1 IFNG IL10 NOS2 TNF
2 hematopoietic system MP:0005397 9.91 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
3 immune system MP:0005387 9.87 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.8 CTLA4 IFNG IL10 NOS2 TNF
5 integument MP:0010771 9.65 CTLA4 IFNG IL10 NOS2 TNF
6 liver/biliary system MP:0005370 9.55 CTLA4 IFNG IL10 NOS2 TNF
7 muscle MP:0005369 9.35 IDO1 IFNG IL10 NOS2 TNF
8 respiratory system MP:0005388 9.02 CTLA4 IFNG IL10 NOS2 TNF

Drugs & Therapeutics for Spotted Fever Rickettsiosis

Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 3, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Immunoglobulins
3 Antibodies

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

Genetic Tests for Spotted Fever Rickettsiosis

Anatomical Context for Spotted Fever Rickettsiosis

MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

40
Skin, Lung, Eye, Bone, Thyroid, T Cells, Testes

Publications for Spotted Fever Rickettsiosis

Articles related to Spotted Fever Rickettsiosis:

(showing 85, show less)
# Title Authors PMID Year
1
An optimized five-color/seven-parameter flow cytometry panel for immunophenotyping guinea pig peripheral blood lymphocytes. 61
31682796 2020
2
A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. 61
31604442 2019
3
Expanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017. 61
31638478 2019
4
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 61
31331735 2019
5
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 61
31134290 2019
6
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
7
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 61
31202622 2019
8
Antibody titers reactive with Rickettsia rickettsii in blood donors and implications for surveillance of spotted fever rickettsiosis in the United States. 61
31267128 2019
9
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 61
31216274 2019
10
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 61
30969821 2019
11
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 61
31084685 2019
12
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 61
30771038 2019
13
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 61
30635303 2019
14
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
15
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 61
30315767 2019
16
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 61
30618452 2018
17
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 61
30274426 2018
18
Fatal spotted fever rickettsiosis in Argentina. 61
29942776 2018
19
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 61
28764157 2017
20
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 61
28576950 2017
21
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 61
28806774 2017
22
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 61
27508322 2016
23
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 61
27318438 2016
24
A Clinical Review of Tick-Borne Diseases in Arkansas. 61
27263175 2016
25
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 61
26432518 2015
26
Spotted fever rickettsiosis in Uttar Pradesh. 61
25900962 2015
27
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 61
25590681 2015
28
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 61
26394396 2015
29
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 61
25533148 2014
30
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 61
25501172 2014
31
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 61
25108779 2014
32
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 61
24742108 2014
33
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 61
24218580 2013
34
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 61
23788593 2013
35
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 61
23363571 2013
36
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 61
23279233 2013
37
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 61
24155949 2013
38
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 61
23140893 2012
39
Gangrene in cases of spotted fever: a report of three cases. 61
23257640 2012
40
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 61
22541336 2012
41
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 61
22634883 2012
42
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 61
23101229 2012
43
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 61
22172164 2011
44
Rickettsia parkeri Rickettsiosis, Argentina. 61
21762568 2011
45
An acarologic survey and Amblyomma americanum distribution map with implications for tularemia risk in Missouri. 61
21363979 2011
46
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. 61
21291605 2011
47
Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia. 61
21340366 2011
48
Acute undifferentiated febrile illness in adult hospitalized patients: the disease spectrum and diagnostic predictors - an experience from a tertiary care hospital in South India. 61
20870680 2010
49
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 61
20233665 2010
50
Proteomic analysis of Rickettsia parkeri strain portsmouth. 61
19797064 2009
51
Rickettsia slovaca and Rickettsia raoultii in Dermacentor marginatus ticks collected on wild boars in Tuscany, Italy. 61
19960702 2009
52
Spotted fever rickettsiosis infection in a traveler from Sri Lanka. 61
19930388 2009
53
CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis. 61
19564386 2009
54
An increase in human cases of spotted fever rickettsiosis in Yucatan, Mexico, involving children. 61
19052302 2008
55
Rocky Mountain spotted fever in Argentina. 61
18385370 2008
56
Description of the first reported human case of spotted fever group rickettsiosis in urban Bangkok. 61
17984348 2007
57
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. 61
17674321 2007
58
Rickettsiae-stimulated dendritic cells mediate protection against lethal rickettsial challenge in an animal model of spotted fever rickettsiosis. 61
17624851 2007
59
Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis. 61
17403875 2007
60
Characterisation of rickettsial diseases in a hospital-based population in Malta. 61
16473410 2006
61
Isolation of Rickettsia akari from eschars of patients with rickettsialpox. 61
17038703 2006
62
Human Infection with Rickettsia honei, Thailand. 61
16229787 2005
63
Rickettsial infections--a threat to travellers? 61
15353963 2004
64
First serologic evidence of human spotted fever group rickettsiosis in Korea. 61
15131221 2004
65
Fatal spotted fever rickettsiosis, Kenya. 61
15200829 2004
66
Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. 61
15039346 2004
67
Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. 61
14999622 2004
68
Acute spotted fever rickettsiosis among febrile patients, Cameroon. 61
15109409 2004
69
Fatal spotted fever rickettsiosis, Minas Gerais, Brazil. 61
14718082 2003
70
Spotted fever rickettsiosis in Coronel Fabriciano, Minas Gerais State. 61
12937725 2003
71
Rickettsialpox in New York City: a persistent urban zoonosis. 61
12860597 2003
72
Serologic evidence of infection with ehrlichiae and spotted fever group rickettsiae among residents of Gag Island, Indonesia. 61
12875301 2003
73
Identification of Ctenocephalides felis fleas as a host of Rickettsia felis, the agent of a spotted fever rickettsiosis in YucataƄ, Mexico. 61
12653300 2002
74
Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis. 61
11738766 2001
75
Tick-borne diseases in Texas: a 10-year retrospective examination of cases. 61
9854421 1998
76
An outbreak of spotted fever rickettsiosis in U.S. Army troops deployed to Botswana. 61
8903233 1996
77
Release of soluble tumor necrosis factor receptors in Mediterranean spotted fever rickettsiosis. 61
8991643 1996
78
Comparative antigenic analysis of spotted fever group rickettsiae from Israel and other closely related organisms. 61
7611567 1995
79
Identification of rickettsiae from ticks collected in the Central African Republic using the polymerase chain reaction. 61
7908504 1994
80
EIA with species-specific monoclonal antibodies: a novel seroepidemiologic tool for determination of the etiologic agent of spotted fever rickettsiosis. 61
7693827 1993
81
Astrakhan fever, a spotted-fever rickettsiosis. 61
1670806 1991
82
In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii. 61
3129987 1988
83
[Two cases of spotted fever rickettsiosis in Kyushu]. 61
3130435 1987
84
Rickettsial and serologic evidence for prevalent spotted fever rickettsiosis in inner Mongolia. 61
3578658 1987
85
Isolation of a spotted fever group rickettsia from a patient and related ecologic investigations in Xinjiang Uygur Autonomous Region of China. 61
3571471 1987

Variations for Spotted Fever Rickettsiosis

Expression for Spotted Fever Rickettsiosis

Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.

Pathways for Spotted Fever Rickettsiosis

Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 37, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.13 TNF NOS2 IL10 IFNG CCL5
2
Show member pathways
12.87 TNF NOS2 IL10 IFNG CCL5
3
Show member pathways
12.66 TNF IL10 IFNG CTLA4
4
Show member pathways
12.43 TNF IL10 IFNG CTLA4
5
Show member pathways
12.41 TNF NOS2 IL10 IFNG
6
Show member pathways
12.16 TNF IL10 CCL5
7
Show member pathways
12.15 TNF IFNG CCL5
8
Show member pathways
12.13 TNF NOS2 IFNG
9 12.03 TNF NOS2 IFNG
10
Show member pathways
12.02 TNF NOS2 IFNG
11
Show member pathways
12.01 TNF NOS2 IL10 IFNG
12 11.96 TNF NOS2 IL10 IFNG
13 11.95 TNF IL10 IFNG IDO1 CTLA4 CCL5
14
Show member pathways
11.9 TNF IL10 IFNG
15 11.86 TNF NOS2 IFNG
16 11.84 TNF IL10 IFNG
17 11.82 TNF NOS2 IL10
18 11.65 TNF IL10 IFNG
19 11.63 TNF NOS2 IL10 IFNG
20 11.61 TNF NOS2 IL10
21
Show member pathways
11.6 TNF IFNG CTLA4
22 11.57 TNF IL10 IFNG
23 11.53 TNF IFNG CTLA4 CCL5
24
Show member pathways
11.49 TNF NOS2 IFNG
25 11.37 TNF IL10 IFNG
26 11.34 IL10 IFNG
27 11.34 TNF IL10 CCL5
28 11.32 TNF IFNG
29 11.31 TNF NOS2 IFNG
30 11.23 NOS2 IFNG
31 11.21 TNF IL10
32 11.16 TNF IFNG
33 11.07 IL10 IFNG
34 11.02 TNF CCL5
35 11.02 TNF IL10 IFNG IDO1
36 11.01 TNF IL10 IFNG
37 10.87 TNF NOS2 IL10 IFNG CCL5

GO Terms for Spotted Fever Rickettsiosis

Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 45, show less)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.85 TNF NOS2 IFNG
2 defense response to bacterium GO:0042742 9.84 TNF NOS2 IL10
3 inflammatory response GO:0006954 9.84 TNF IL10 IDO1 CCL5
4 cellular response to lipopolysaccharide GO:0071222 9.81 TNF NOS2 IL10
5 response to lipopolysaccharide GO:0032496 9.81 NOS2 IL10 IDO1
6 cytokine-mediated signaling pathway GO:0019221 9.76 TNF NOS2 IL10 CCL5
7 response to virus GO:0009615 9.74 TNF IFNG CCL5
8 positive regulation of phagocytosis GO:0050766 9.7 TNF IFNG
9 interleukin-12-mediated signaling pathway GO:0035722 9.69 IL10 IFNG
10 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF IFNG
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 TNF IFNG
12 negative regulation of viral genome replication GO:0045071 9.68 TNF CCL5
13 positive regulation of protein complex assembly GO:0031334 9.68 TNF IFNG
14 protein kinase B signaling GO:0043491 9.68 TNF CCL5
15 negative regulation of mitotic cell cycle GO:0045930 9.68 TNF IL10
16 negative regulation of interleukin-6 production GO:0032715 9.67 TNF IL10
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF CCL5
18 regulation of synapse organization GO:0050807 9.66 TNF IL10
19 positive regulation of cytokine secretion GO:0050715 9.65 TNF IL10
20 microglial cell activation GO:0001774 9.65 TNF IFNG
21 positive regulation of interleukin-12 production GO:0032735 9.65 IFNG IDO1
22 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TNF IFNG CCL5
23 positive regulation of osteoclast differentiation GO:0045672 9.64 TNF IFNG
24 positive regulation of amyloid-beta formation GO:1902004 9.63 TNF IFNG
25 astrocyte activation GO:0048143 9.62 TNF IFNG
26 negative regulation of B cell proliferation GO:0030889 9.62 IL10 CTLA4
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 TNF IFNG
28 regulation of regulatory T cell differentiation GO:0045589 9.61 IFNG CTLA4
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.6 TNF IL10
30 positive regulation of chemokine biosynthetic process GO:0045080 9.59 TNF IFNG
31 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF IFNG
32 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IFNG
33 negative regulation of T cell apoptotic process GO:0070233 9.56 IDO1 CCL5
34 endothelial cell apoptotic process GO:0072577 9.55 TNF IL10
35 immune response GO:0006955 9.55 TNF IL10 IFNG CTLA4 CCL5
36 negative regulation of T cell proliferation GO:0042130 9.54 IL10 IDO1 CTLA4
37 positive regulation of T cell apoptotic process GO:0070234 9.52 IDO1 CCL5
38 positive regulation of killing of cells of other organism GO:0051712 9.51 NOS2 IFNG
39 negative regulation of cytokine secretion involved in immune response GO:0002740 9.49 TNF IL10
40 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IFNG
41 receptor biosynthetic process GO:0032800 9.4 TNF IL10
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.32 TNF IFNG
43 positive regulation of nitrogen compound metabolic process GO:0051173 9.26 TNF IFNG
44 positive regulation of JAK-STAT cascade GO:0046427 9.13 TNF IL10 CCL5
45 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5

Sources for Spotted Fever Rickettsiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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