MCID: SPT024
MIFTS: 37

Spotted Fever Rickettsiosis

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Spotted Fever Rickettsiosis

Summaries for Spotted Fever Rickettsiosis

MalaCards based summary : Spotted Fever Rickettsiosis, also known as spotted fever rickettsiae disease, is related to exanthem and african tick-bite fever. An important gene associated with Spotted Fever Rickettsiosis is CCL5 (C-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs carbamide peroxide and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and endothelial, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Spotted Fever Rickettsiosis

Diseases related to Spotted Fever Rickettsiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 252, show less)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.9 TNF CTLA4
2 african tick-bite fever 30.8 IFNG CCL5
3 chikungunya 30.5 TNF CCL5
4 typhoid fever 30.4 TNF IFNG
5 spotted fever 30.4 TNF IL10 IFNG CCL5
6 q fever 29.7 TNF IL10 IFNG
7 leptospirosis 29.7 TNF IL10 IFNG
8 chlamydia 28.0 TNF NOS2 IL10 IFNG IDO1
9 boutonneuse fever 10.5
10 rickettsial disease 10.5
11 rocky mountain spotted fever 10.4
12 scorpion envenomation 10.4 TNF CCL5
13 stachybotrys chartarum 10.4 TNF CCL5
14 folliculitis 10.4 IFNG CCL5
15 viral meningitis 10.3 IFNG CCL5
16 sympathetic ophthalmia 10.3 TNF CTLA4
17 eumycotic mycetoma 10.3 IFNG CCL5
18 inclusion conjunctivitis 10.3 TNF CCL5
19 urinary schistosomiasis 10.3 IFNG CTLA4
20 japanese encephalitis 10.3 TNF CCL5
21 stevens-johnson syndrome/toxic epidermal necrolysis 10.3 IFNG CCL5
22 vulvovaginitis 10.3 IL10 CCL5
23 toxic oil syndrome 10.3 IFNG IDO1
24 listeriosis 10.3 TNF IDO1
25 epidemic typhus 10.3
26 autoimmune disease of endocrine system 10.3 IFNG CTLA4
27 staphylococcal toxic shock syndrome 10.3 TNF IFNG
28 autoimmune myocarditis 10.3 TNF IFNG
29 autoimmune disease of gastrointestinal tract 10.3 IFNG CTLA4
30 chronic beryllium disease 10.2 TNF IFNG
31 trichosporonosis 10.2 TNF IFNG
32 griscelli syndrome, type 2 10.2 IL10 CCL5
33 scleritis 10.2 TNF IFNG
34 griscelli syndrome 10.2 IL10 CCL5
35 miliary tuberculosis 10.2 TNF IFNG
36 microscopic colitis 10.2 TNF IFNG
37 genital herpes 10.2 IL10 CCL5
38 central nervous system vasculitis 10.2 TNF IFNG
39 meconium aspiration syndrome 10.2 TNF IFNG
40 soft tissue sarcoma 10.2 TNF IFNG
41 tuberculous peritonitis 10.2 TNF IFNG
42 posterior uveitis 10.2 TNF IFNG
43 cytomegalovirus retinitis 10.2 TNF IFNG
44 lichen disease 10.2 TNF IFNG
45 pleural tuberculosis 10.2 TNF IFNG
46 erythema multiforme 10.2 TNF IFNG
47 punctate inner choroidopathy 10.2 TNF IL10
48 tropical endomyocardial fibrosis 10.2 TNF IL10
49 endomyocardial fibrosis 10.2 TNF IL10
50 cephalosporin allergy 10.2 IL10 IFNG
51 rasmussen encephalitis 10.2 TNF IFNG
52 hyperlucent lung 10.2 IL10 IFNG
53 hypersensitivity reaction type iv disease 10.2 TNF IFNG
54 multifocal choroiditis 10.2 TNF IL10
55 choroiditis 10.2 TNF IL10
56 sporotrichosis 10.2 IL10 IFNG
57 tungiasis 10.2 TNF IL10
58 autoimmune pancreatitis 10.2 IL10 CTLA4
59 transient hypogammaglobulinemia 10.2 TNF IL10
60 nickel allergic contact dermatitis 10.2 IL10 IFNG
61 baylisascariasis 10.1 IL10 IFNG
62 cow milk allergy 10.1 TNF IL10
63 trichuriasis 10.1 TNF IL10
64 mucocutaneous leishmaniasis 10.1 TNF IL10
65 pericardial tuberculosis 10.1 IL10 IFNG
66 fungal meningitis 10.1 IL10 IFNG
67 hepatitis e 10.1 TNF IFNG
68 tuberculoid leprosy 10.1 IL10 IFNG
69 multicentric castleman disease 10.1 IL10 IFNG
70 castleman disease 10.1 IL10 IFNG
71 autoimmune gastritis 10.1 TNF IL10
72 keratoconjunctivitis 10.1 TNF IFNG
73 fascioliasis 10.1 IL10 IFNG
74 peanut allergy 10.1 IL10 IFNG
75 transverse myelitis 10.1 TNF IL10
76 immune deficiency disease 10.1
77 branchiootic syndrome 1 10.1
78 cyanosis, transient neonatal 10.1
79 endemic typhus 10.1
80 visual epilepsy 10.1
81 neutropenia 10.1
82 thrombocytopenia 10.1
83 47,xyy 10.1
84 splenomegaly 10.1
85 febrile seizures 10.1
86 seizure disorder 10.1
87 tremor 10.1
88 multidrug-resistant tuberculosis 10.1 TNF IL10
89 hand, foot and mouth disease 10.1 IL10 IFNG
90 post-transplant lymphoproliferative disease 10.1 TNF IL10
91 buruli ulcer 10.1 IL10 IFNG
92 pleurisy 10.1 TNF IFNG
93 primary peritoneal carcinoma 10.1 IL10 IFNG
94 panuveitis 10.1 TNF IL10
95 lacrimal apparatus disease 10.1 TNF IL10
96 polyradiculoneuropathy 10.1 IL10 IFNG
97 churg-strauss syndrome 10.1 TNF IL10
98 commensal bacterial infectious disease 10.1 TNF IL10
99 epstein-barr virus-associated gastric carcinoma 10.1 TNF IL10
100 paranasal sinus disease 10.1 IL10 IFNG
101 extrapulmonary tuberculosis 10.1 IL10 IFNG
102 aphthous stomatitis 10.1 TNF IL10
103 complex regional pain syndrome 10.1 TNF IL10
104 pericarditis 10.1 TNF IFNG
105 extrinsic cardiomyopathy 10.0 TNF IL10
106 rheumatic fever 10.0 TNF IL10
107 keratoconjunctivitis sicca 10.0 TNF IL10
108 lymph node disease 10.0 TNF IL10
109 prostatitis 10.0 TNF IL10
110 herpes zoster 10.0 IL10 IFNG
111 uveal disease 10.0 TNF IL10
112 smallpox 10.0 TNF IFNG
113 nose disease 10.0 TNF IL10
114 rheumatic heart disease 10.0 TNF IL10
115 peptic ulcer disease 10.0 TNF IL10
116 tonsillitis 10.0 TNF IFNG
117 pyelonephritis 10.0 TNF IL10
118 primary progressive multiple sclerosis 10.0 TNF IL10
119 dystrophinopathies 10.0 TNF NOS2
120 parasitic helminthiasis infectious disease 9.9 TNF IL10
121 mumps 9.9 TNF IFNG
122 appendicitis 9.9 TNF IL10
123 arthus reaction 9.9 TNF NOS2
124 extrinsic allergic alveolitis 9.9 IL10 CCL5
125 severe acute respiratory syndrome 9.9 TNF IFNG CCL5
126 neuritis 9.9 TNF IFNG CCL5
127 temporal arteritis 9.9 TNF IFNG CCL5
128 pulmonary sarcoidosis 9.9 TNF IFNG CCL5
129 ige responsiveness, atopic 9.9 IL10 IFNG
130 alopecia areata 9.9 TNF IFNG CTLA4
131 pulmonary fibrosis, idiopathic 9.9 TNF IFNG CCL5
132 secondary progressive multiple sclerosis 9.9 IL10 IFNG
133 hepatitis b 9.9 TNF IFNG CTLA4
134 lung disease 9.9 TNF IL10 CCL5
135 autoimmune disease of eyes, ear, nose and throat 9.9 TNF IL10 CCL5
136 pneumonia 9.9 TNF IL10 CCL5
137 viral encephalitis 9.8 TNF IL10 CCL5
138 idiopathic neutropenia 9.8 TNF IL10 CCL5
139 tropical spastic paraparesis 9.8 IL10 IFNG CCL5
140 hepatopulmonary syndrome 9.8 TNF NOS2
141 bronchial disease 9.8 TNF IL10 CCL5
142 adult respiratory distress syndrome 9.8 TNF IL10
143 allergic asthma 9.8 IL10 IFNG CCL5
144 allergic hypersensitivity disease 9.8 IL10 IFNG CCL5
145 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8 IL10 IFNG CTLA4
146 lupus erythematosus 9.8 TNF IL10 CTLA4
147 trachoma 9.8 TNF IL10 IDO1
148 scrub typhus 9.8 TNF IL10 IDO1
149 diabetes mellitus, insulin-dependent 9.8 IL10 IFNG CTLA4
150 autoimmune disease of musculoskeletal system 9.8 TNF IL10
151 bacterial meningitis 9.7 TNF IL10
152 chronic graft versus host disease 9.7 TNF IL10 IFNG
153 clonorchiasis 9.7 TNF IL10 IFNG
154 intermediate uveitis 9.7 TNF IL10 IFNG
155 poliomyelitis 9.7 TNF IL10 IFNG
156 mycoplasma pneumoniae pneumonia 9.7 TNF IL10 IFNG
157 primary systemic mycosis 9.7 TNF IL10 IFNG
158 arthritis 9.7 TNF IL10 IFNG
159 coccidiosis 9.7 TNF IL10 IFNG
160 aseptic meningitis 9.7 TNF IL10 IFNG
161 meningitis 9.7 TNF IL10 IFNG
162 plasmodium vivax malaria 9.7 TNF IL10 IFNG
163 acute graft versus host disease 9.7 TNF IL10 IFNG
164 leprosy 3 9.7 TNF IL10 IFNG
165 spondyloarthropathy 9.7 TNF IL10 IFNG
166 lepromatous leprosy 9.7 TNF IL10 IFNG
167 mixed connective tissue disease 9.7 TNF IL10 IFNG
168 connective tissue disease 9.7 TNF IL10 IFNG
169 testicular disease 9.7 TNF IL10 IFNG
170 opportunistic mycosis 9.7 TNF IL10 IFNG
171 autoimmune uveitis 9.7 TNF IL10 IFNG
172 echinococcosis 9.7 TNF IL10 IFNG
173 reactive arthritis 9.7 TNF IL10 IFNG
174 melioidosis 9.7 TNF IL10 IFNG
175 hepatitis a 9.7 TNF IL10 IFNG
176 brucellosis 9.7 TNF IL10 IFNG
177 bronchiolitis obliterans 9.7 TNF IL10 IFNG
178 parasitic protozoa infectious disease 9.7 TNF IL10 IFNG
179 dengue hemorrhagic fever 9.7 TNF IL10 IFNG
180 allergic contact dermatitis 9.7 TNF IL10 IFNG
181 contact dermatitis 9.7 TNF IL10 IFNG
182 primary bacterial infectious disease 9.7 TNF IL10 IFNG
183 bacterial infectious disease 9.7 TNF IL10 IFNG
184 cutaneous leishmaniasis 9.7 TNF IL10 IFNG
185 chronic mucocutaneous candidiasis 9.7 TNF IL10 IFNG
186 lymphadenitis 9.7 TNF IL10 IFNG
187 osteomyelitis 9.7 TNF IL10 IFNG
188 bone inflammation disease 9.7 TNF IL10 IFNG
189 aspergillosis 9.7 TNF IL10 IFNG
190 toxic shock syndrome 9.7 TNF IL10 IFNG
191 toxoplasmosis 9.7 TNF IL10 IFNG
192 schistosomiasis 9.7 TNF IL10 IFNG
193 plasmodium falciparum malaria 9.7 TNF IL10 IFNG
194 graft-versus-host disease 9.7 TNF IL10 IFNG
195 acquired immunodeficiency syndrome 9.7 TNF IL10 IFNG
196 periodontitis 9.7 TNF IL10 IFNG
197 mouth disease 9.7 TNF IL10 IFNG
198 pulmonary tuberculosis 9.7 TNF IL10 IFNG
199 omenn syndrome 9.7 TNF IL10 IFNG
200 rheumatic disease 9.7 TNF IL10 IFNG
201 immune system disease 9.7 TNF IL10 IFNG
202 mycobacterium tuberculosis 1 9.7 TNF IL10 IFNG
203 gastrointestinal system disease 9.7 TNF IL10 IFNG
204 hemophagocytic lymphohistiocytosis 9.7 TNF IL10 IFNG
205 ulcerative colitis 9.7 TNF IL10 IFNG
206 aggressive periodontitis 9.7 TNF IL10
207 inflammatory bowel disease 9.7 TNF IL10 IFNG
208 sleeping sickness 9.6 NOS2 IL10
209 skin disease 9.6 TNF IL10 IFNG
210 large intestine cancer 9.6 TNF IL10 IFNG
211 mycetoma 9.6 NOS2 IL10 CCL5
212 pulmonary edema 9.6 TNF IL10
213 crohn's colitis 9.5 TNF NOS2 IFNG
214 central nervous system disease 9.5 TNF NOS2 IFNG
215 spinal cord injury 9.5 TNF NOS2
216 idiopathic achalasia 9.4 TNF NOS2 IL10
217 bacterial sepsis 9.4 TNF NOS2 IL10
218 chronic active epstein-barr virus infection 9.4 IL10 IFNG IDO1 CTLA4
219 food allergy 9.4 IL10 IFNG
220 orofacial granulomatosis 9.4 TNF IL10 IFNG CCL5
221 human immunodeficiency virus infectious disease 9.4 TNF IL10 IFNG CCL5
222 autoimmune disease of central nervous system 9.4 TNF IL10 IFNG CCL5
223 upper respiratory tract disease 9.4 TNF IL10 IFNG CCL5
224 bronchiolitis 9.4 TNF IL10 IFNG CCL5
225 relapsing-remitting multiple sclerosis 9.4 TNF IL10 IFNG CCL5
226 respiratory system disease 9.4 TNF IL10 IFNG CCL5
227 demyelinating disease 9.4 TNF IL10 IFNG CCL5
228 interstitial lung disease 9.4 TNF IL10 IFNG CCL5
229 viral infectious disease 9.4 TNF IL10 IFNG CCL5
230 dermatitis, atopic 9.4 TNF IL10 IFNG CCL5
231 hematopoietic stem cell transplantation 9.3 TNF IL10 IFNG CTLA4
232 paracoccidioidomycosis 9.3 TNF IL10 IFNG CTLA4
233 autoimmune disease 9.3 TNF IL10 IFNG CTLA4
234 uveitis 9.3 TNF IL10 IFNG CTLA4
235 myasthenia gravis 9.3 TNF IL10 IFNG CTLA4
236 behcet syndrome 9.3 TNF IL10 IFNG CTLA4
237 asthma 9.3 TNF IL10 IFNG CCL5
238 common variable immunodeficiency 9.3 TNF IL10 IFNG CTLA4
239 filariasis 9.0 TNF IL10 IFNG CTLA4 CCL5
240 rheumatoid arthritis 9.0 TNF IL10 IFNG CTLA4 CCL5
241 eales disease 9.0 TNF NOS2 IL10 IFNG
242 visceral leishmaniasis 9.0 TNF NOS2 IL10 IFNG
243 leishmaniasis 9.0 TNF NOS2 IL10 IFNG
244 systemic lupus erythematosus 9.0 TNF IL10 IFNG CTLA4 CCL5
245 chagas disease 8.9 TNF NOS2 IL10 IFNG
246 trypanosomiasis 8.9 TNF IL10 IFNG IDO1 CCL5
247 nervous system disease 8.9 TNF NOS2 IL10 IFNG
248 human immunodeficiency virus type 1 8.9 TNF IL10 IFNG IDO1 CCL5
249 proteasome-associated autoinflammatory syndrome 1 8.6 TNF NOS2 IL10 IFNG CCL5
250 colitis 8.6 TNF NOS2 IL10 IFNG CTLA4
251 multiple sclerosis 8.2 TNF NOS2 IL10 IFNG CTLA4 CCL5
252 malaria 7.8 TNF NOS2 IL10 IFNG IDO1 CTLA4

Graphical network of the top 20 diseases related to Spotted Fever Rickettsiosis:



Diseases related to Spotted Fever Rickettsiosis

Symptoms & Phenotypes for Spotted Fever Rickettsiosis

MGI Mouse Phenotypes related to Spotted Fever Rickettsiosis:

46 (showing 12, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
2 cardiovascular system MP:0005385 9.99 CTLA4 IDO1 IFNG IL10 NOS2 TNF
3 immune system MP:0005387 9.98 CCL5 CTLA4 IDO1 IFNG IL10 NOS2
4 digestive/alimentary MP:0005381 9.89 CTLA4 IFNG IL10 NOS2 TNF
5 endocrine/exocrine gland MP:0005379 9.88 CTLA4 IFNG IL10 NOS2 TNF
6 integument MP:0010771 9.8 CTLA4 IFNG IL10 NOS2 TNF
7 liver/biliary system MP:0005370 9.77 CTLA4 IFNG IL10 NOS2 TNF
8 muscle MP:0005369 9.72 IDO1 IFNG IL10 NOS2 TNF
9 neoplasm MP:0002006 9.56 IFNG IL10 NOS2 TNF
10 reproductive system MP:0005389 9.55 IDO1 IFNG IL10 NOS2 TNF
11 respiratory system MP:0005388 9.35 CTLA4 IFNG IL10 NOS2 TNF
12 skeleton MP:0005390 9.02 CTLA4 IFNG IL10 NOS2 TNF

Drugs & Therapeutics for Spotted Fever Rickettsiosis

Drugs for Spotted Fever Rickettsiosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 3, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2 Antibodies
3 Immunoglobulins

Interventional clinical trials:

(showing 1, show less)
# Name Status NCT ID Phase Drugs
1 Background Seroprevalence of Rickettsial Infections in Myanmar Not yet recruiting NCT03847870

Search NIH Clinical Center for Spotted Fever Rickettsiosis

Genetic Tests for Spotted Fever Rickettsiosis

Anatomical Context for Spotted Fever Rickettsiosis

MalaCards organs/tissues related to Spotted Fever Rickettsiosis:

41
Testes, Skin, Endothelial

Publications for Spotted Fever Rickettsiosis

Articles related to Spotted Fever Rickettsiosis:

(showing 82, show less)
# Title Authors PMID Year
1
HLA-B27 spondyloarthritis and spotted fever rickettsiosis: case-based review. 38
31134290 2019
2
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 38
31097370 2019
3
Molecular evidence of Borrelia burgdorferi sensu stricto and Rickettsia massiliae in ticks collected from a domestic-wild carnivore interface in Chihuahua, Mexico. 38
31202622 2019
4
Antibody titers reactive with Rickettsia rickettsii in blood donors and implications for surveillance of spotted fever rickettsiosis in the United States. 38
31267128 2019
5
Phenology of Amblyomma sculptum in a degraded area of Atlantic rainforest in north-eastern Brazil. 38
31331735 2019
6
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 38
31216274 2019
7
National Surveillance Data Show Increase in Spotted Fever Rickettsiosis: United States, 2016-2017. 38
30969821 2019
8
Spotted fever rickettsiosis in South Africa: Evaluation of laboratory diagnostic capacity and inter-laboratory comparison of serological testing. 38
31084685 2019
9
Amblyomma maculatum-associated rickettsiae in vector tissues and vertebrate hosts during tick feeding. 38
30771038 2019
10
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 38
30315767 2019
11
Severe leptospirosis in a patient with positive serological test for spotted fever rickettsiosis. 38
30635303 2019
12
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 38
30197269 2019
13
Attempt to uncover reservoirs of human spotted fever rickettsiosis on the Fleurieu Peninsula, South Australia. 38
30618452 2018
14
Spotted Fever Rickettsiosis in a Wildlife Researcher in Sabah, Malaysia: A Case Study. 38
30274426 2018
15
Fatal spotted fever rickettsiosis in Argentina. 38
29942776 2018
16
Seroepidemiology of Spotted Fever Rickettsiosis in Uttar Pradesh: A Prospective Study. 38
28764157 2017
17
Retrospective Case Reports of Two Central North Carolina Residents: Frequency of Tick Bites and Associated Illnesses, 2001-2014. 38
28576950 2017
18
Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium. 38
28806774 2017
19
Comparative growth of spotted fever group Rickettsia spp. strains in Vero cells. 38
27508322 2016
20
Prevalence of Rickettsia species in Dermacentor variabilis ticks from Ontario, Canada. 38
27318438 2016
21
A Clinical Review of Tick-Borne Diseases in Arkansas. 38
27263175 2016
22
Evaluation of a new serological test for the detection of anti-Coxiella and anti-Rickettsia antibodies. 38
26432518 2015
23
Spotted fever rickettsiosis in Uttar Pradesh. 38
25900962 2015
24
Rickettsia massiliae and Rickettsia conorii Israeli Spotted Fever Strain Differentially Regulate Endothelial Cell Responses. 38
26394396 2015
25
Incidence of notifiable diseases among American Indians/Alaska Natives - United States, 2007-2011. 38
25590681 2015
26
Prevalence of Rickettsiales in ticks removed from the skin of outdoor workers in North Carolina. 38
25533148 2014
27
Isolation and characterization of microsatellite loci from the tick Amblyomma aureolatum (Acari: Ixodidae). 38
25501172 2014
28
Quantitative study of Rickettsia massiliae in Rhipicephalus sanguineus organs. 38
25108779 2014
29
Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon. 38
24742108 2014
30
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses. 38
24218580 2013
31
A case of spotted fever rickettsiosis in a human immunodeficiency virus-positive patient. 38
23788593 2013
32
In vitro isolation from Amblyomma ovale (Acari: Ixodidae) and ecological aspects of the Atlantic rainforest Rickettsia, the causative agent of a novel spotted fever rickettsiosis in Brazil. 38
23363571 2013
33
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. 38
23279233 2013
34
Natural blood feeding and temperature shift modulate the global transcriptional profile of Rickettsia rickettsii infecting its tick vector. 38
24155949 2013
35
Urban family cluster of spotted fever rickettsiosis linked to Rhipicephalus sanguineus infected with Rickettsia conorii subsp. caspia and Rickettsia massiliae. 38
23140893 2012
36
Gangrene in cases of spotted fever: a report of three cases. 38
23257640 2012
37
A case series of spotted fever rickettsiosis with neurological manifestations in Sri Lanka. 38
22541336 2012
38
Rickettsia parkeri: a Rickettsial pathogen transmitted by ticks in endemic areas for spotted fever rickettsiosis in southern Uruguay. 38
22634883 2012
39
Spotted fever rickettsiosis caused by Rickettsia raoultii--case report. 38
23101229 2012
40
Rickettsia parkeri in Amblyomma maculatum ticks, North Carolina, USA, 2009-2010. 38
22172164 2011
41
Rickettsia parkeri Rickettsiosis, Argentina. 38
21762568 2011
42
An acarologic survey and Amblyomma americanum distribution map with implications for tularemia risk in Missouri. 38
21363979 2011
43
Outbreak of Rocky Mountain spotted fever in Córdoba, Colombia. 38
21340366 2011
44
Eschar-associated spotted fever rickettsiosis, Bahia, Brazil. 38
21291605 2011
45
Acute undifferentiated febrile illness in adult hospitalized patients: the disease spectrum and diagnostic predictors - an experience from a tertiary care hospital in South India. 38
20870680 2010
46
African tick-bite fever: a new entity in the differential diagnosis of multiple eschars in travelers. Description of five cases imported from South Africa to Switzerland. 38
20233665 2010
47
Proteomic analysis of Rickettsia parkeri strain portsmouth. 38
19797064 2009
48
Spotted fever rickettsiosis infection in a traveler from Sri Lanka. 38
19930388 2009
49
Rickettsia slovaca and Rickettsia raoultii in Dermacentor marginatus ticks collected on wild boars in Tuscany, Italy. 38
19960702 2009
50
CD4+ CD25+ Foxp3- T-regulatory cells produce both gamma interferon and interleukin-10 during acute severe murine spotted fever rickettsiosis. 38
19564386 2009
51
An increase in human cases of spotted fever rickettsiosis in Yucatan, Mexico, involving children. 38
19052302 2008
52
Rocky Mountain spotted fever in Argentina. 38
18385370 2008
53
Description of the first reported human case of spotted fever group rickettsiosis in urban Bangkok. 38
17984348 2007
54
Intralesional expression of mRNA of interferon- gamma , tumor necrosis factor- alpha , interleukin-10, nitric oxide synthase, indoleamine-2,3-dioxygenase, and RANTES is a major immune effector in Mediterranean spotted fever rickettsiosis. 38
17674321 2007
55
Rickettsiae-stimulated dendritic cells mediate protection against lethal rickettsial challenge in an animal model of spotted fever rickettsiosis. 38
17624851 2007
56
Differential interaction of dendritic cells with Rickettsia conorii: impact on host susceptibility to murine spotted fever rickettsiosis. 38
17403875 2007
57
Characterisation of rickettsial diseases in a hospital-based population in Malta. 38
16473410 2006
58
Isolation of Rickettsia akari from eschars of patients with rickettsialpox. 38
17038703 2006
59
Human Infection with Rickettsia honei, Thailand. 38
16229787 2005
60
Rickettsial infections--a threat to travellers? 38
15353963 2004
61
First serologic evidence of human spotted fever group rickettsiosis in Korea. 38
15131221 2004
62
Fatal spotted fever rickettsiosis, Kenya. 38
15200829 2004
63
Fc-dependent polyclonal antibodies and antibodies to outer membrane proteins A and B, but not to lipopolysaccharide, protect SCID mice against fatal Rickettsia conorii infection. 38
15039346 2004
64
Rickettsia parkeri: a newly recognized cause of spotted fever rickettsiosis in the United States. 38
14999622 2004
65
Acute spotted fever rickettsiosis among febrile patients, Cameroon. 38
15109409 2004
66
Fatal spotted fever rickettsiosis, Minas Gerais, Brazil. 38
14718082 2003
67
Spotted fever rickettsiosis in Coronel Fabriciano, Minas Gerais State. 38
12937725 2003
68
Rickettsialpox in New York City: a persistent urban zoonosis. 38
12860597 2003
69
Serologic evidence of infection with ehrlichiae and spotted fever group rickettsiae among residents of Gag Island, Indonesia. 38
12875301 2003
70
Identification of Ctenocephalides felis fleas as a host of Rickettsia felis, the agent of a spotted fever rickettsiosis in YucataƄ, Mexico. 38
12653300 2002
71
Immunization with a portion of rickettsial outer membrane protein A stimulates protective immunity against spotted fever rickettsiosis. 38
11738766 2001
72
Tick-borne diseases in Texas: a 10-year retrospective examination of cases. 38
9854421 1998
73
An outbreak of spotted fever rickettsiosis in U.S. Army troops deployed to Botswana. 38
8903233 1996
74
Release of soluble tumor necrosis factor receptors in Mediterranean spotted fever rickettsiosis. 38
8991643 1996
75
Comparative antigenic analysis of spotted fever group rickettsiae from Israel and other closely related organisms. 38
7611567 1995
76
Identification of rickettsiae from ticks collected in the Central African Republic using the polymerase chain reaction. 38
7908504 1994
77
EIA with species-specific monoclonal antibodies: a novel seroepidemiologic tool for determination of the etiologic agent of spotted fever rickettsiosis. 38
7693827 1993
78
Astrakhan fever, a spotted-fever rickettsiosis. 38
1670806 1991
79
In vitro evaluation of josamycin, spiramycin, and erythromycin against Rickettsia rickettsii and R. conorii. 38
3129987 1988
80
[Two cases of spotted fever rickettsiosis in Kyushu]. 38
3130435 1987
81
Rickettsial and serologic evidence for prevalent spotted fever rickettsiosis in inner Mongolia. 38
3578658 1987
82
Isolation of a spotted fever group rickettsia from a patient and related ecologic investigations in Xinjiang Uygur Autonomous Region of China. 38
3571471 1987

Variations for Spotted Fever Rickettsiosis

Expression for Spotted Fever Rickettsiosis

Search GEO for disease gene expression data for Spotted Fever Rickettsiosis.

Pathways for Spotted Fever Rickettsiosis

Pathways related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 46, show less)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 TNF NOS2 IL10 IFNG CTLA4 CCL5
2
Show member pathways
13.43 TNF NOS2 IL10 IFNG CCL5
3
Show member pathways
13.12 TNF NOS2 IL10 IFNG CCL5
4
Show member pathways
12.84 TNF NOS2 IL10 IFNG CCL5
5
Show member pathways
12.67 TNF IL10 IFNG CTLA4
6
Show member pathways
12.41 TNF NOS2 IL10 IFNG
7
Show member pathways
12.4 TNF IL10 IFNG
8
Show member pathways
12.37 TNF IL10 IFNG CTLA4
9
Show member pathways
12.16 TNF IFNG CCL5
10
Show member pathways
12.13 TNF NOS2 IFNG
11
Show member pathways
12.07 TNF IL10 IFNG
12 12.02 TNF NOS2 IFNG
13
Show member pathways
12.02 TNF NOS2 IFNG
14
Show member pathways
12.01 TNF NOS2 IL10 IFNG
15 11.96 TNF NOS2 IL10 IFNG
16 11.95 TNF IL10 IFNG IDO1 CTLA4 CCL5
17
Show member pathways
11.9 TNF IL10 IFNG
18
Show member pathways
11.89 IL10 IFNG CCL5
19 11.86 TNF NOS2 IFNG
20 11.84 TNF IL10 IFNG
21 11.82 TNF NOS2 IL10
22 11.66 TNF IL10 IFNG
23 11.63 TNF NOS2 IL10 IFNG
24 11.62 TNF NOS2 IL10
25
Show member pathways
11.61 TNF IFNG CTLA4
26 11.59 TNF IL10 IFNG
27 11.53 TNF IFNG CTLA4 CCL5
28
Show member pathways
11.51 TNF NOS2 IFNG
29 11.44 NOS2 IFNG
30 11.4 TNF IFNG
31
Show member pathways
11.38 TNF IFNG
32 11.36 TNF IFNG
33 11.36 TNF IL10 IFNG
34 11.34 IL10 IFNG
35 11.34 TNF IL10 CCL5
36 11.32 TNF IFNG
37 11.31 TNF NOS2 IFNG
38 11.23 NOS2 IFNG
39 11.21 TNF IL10
40 11.16 TNF IFNG
41 11.07 IL10 IFNG
42 11.04 TNF IL10 CCL5
43 11.02 TNF CCL5
44 11.02 TNF IL10 IFNG IDO1
45 11.01 TNF IL10 IFNG
46 10.87 TNF NOS2 IL10 IFNG CCL5

GO Terms for Spotted Fever Rickettsiosis

Biological processes related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 40, show less)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.85 TNF IDO1 CTLA4
2 negative regulation of gene expression GO:0010629 9.82 TNF NOS2 IFNG
3 defense response to bacterium GO:0042742 9.81 TNF NOS2 IL10
4 inflammatory response GO:0006954 9.8 TNF IL10 IDO1 CCL5
5 response to lipopolysaccharide GO:0032496 9.77 NOS2 IL10 IDO1
6 cellular response to lipopolysaccharide GO:0071222 9.77 TNF NOS2 IL10
7 cytokine-mediated signaling pathway GO:0019221 9.73 TNF NOS2 IL10 CCL5
8 response to virus GO:0009615 9.71 TNF IFNG CCL5
9 positive regulation of protein localization to plasma membrane GO:1903078 9.68 TNF IFNG
10 positive regulation of cell adhesion GO:0045785 9.68 TNF CCL5
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.67 TNF IL10
12 interleukin-12-mediated signaling pathway GO:0035722 9.67 IL10 IFNG
13 extrinsic apoptotic signaling pathway GO:0097191 9.67 TNF IFNG
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.66 TNF IFNG
15 negative regulation of viral genome replication GO:0045071 9.66 TNF CCL5
16 protein kinase B signaling GO:0043491 9.65 TNF CCL5
17 negative regulation of mitotic cell cycle GO:0045930 9.65 TNF IL10
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF CCL5
19 negative regulation of interleukin-6 production GO:0032715 9.63 TNF IL10
20 regulation of synapse organization GO:0050807 9.63 TNF IL10
21 positive regulation of cytokine secretion GO:0050715 9.62 TNF IL10
22 positive regulation of protein complex assembly GO:0031334 9.62 TNF IFNG
23 positive regulation of interleukin-12 production GO:0032735 9.61 IFNG IDO1
24 positive regulation of osteoclast differentiation GO:0045672 9.61 TNF IFNG
25 regulation of regulatory T cell differentiation GO:0045589 9.58 IFNG CTLA4
26 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.58 TNF IFNG
27 negative regulation of B cell proliferation GO:0030889 9.57 IL10 CTLA4
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 TNF IL10
29 negative regulation of growth of symbiont in host GO:0044130 9.55 TNF IL10
30 negative regulation of T cell apoptotic process GO:0070233 9.52 IDO1 CCL5
31 endothelial cell apoptotic process GO:0072577 9.51 TNF IL10
32 positive regulation of T cell apoptotic process GO:0070234 9.48 IDO1 CCL5
33 negative regulation of cytokine secretion involved in immune response GO:0002740 9.46 TNF IL10
34 negative regulation of T cell proliferation GO:0042130 9.43 IL10 IDO1 CTLA4
35 positive regulation of killing of cells of other organism GO:0051712 9.4 NOS2 IFNG
36 receptor biosynthetic process GO:0032800 9.37 TNF IL10
37 immune response GO:0006955 9.35 TNF IL10 IFNG CTLA4 CCL5
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.32 TNF IFNG
39 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 TNF IFNG
40 regulation of insulin secretion GO:0050796 8.92 TNF NOS2 IFNG CCL5

Molecular functions related to Spotted Fever Rickettsiosis according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 TNF IL10 IFNG CCL5

Sources for Spotted Fever Rickettsiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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