MCID: SQM003
MIFTS: 26

Squamous Blepharitis

Categories: Eye diseases

Aliases & Classifications for Squamous Blepharitis

MalaCards integrated aliases for Squamous Blepharitis:

Name: Squamous Blepharitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13825
ICD9CM 34 373.02
SNOMED-CT 67 58912008
ICD10 32 H01.02
UMLS 71 C0155174

Summaries for Squamous Blepharitis

MalaCards based summary : Squamous Blepharitis is related to blepharitis and acneiform dermatitis. An important gene associated with Squamous Blepharitis is PXT1 (Peroxisomal Testis Enriched Protein 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and IL-2 Pathway. Affiliated tissues include eye, bone marrow and bone, and related phenotypes are cardiovascular system and integument

Related Diseases for Squamous Blepharitis

Diseases related to Squamous Blepharitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 blepharitis 10.2
2 acneiform dermatitis 10.0 PXT1 ERBB4
3 ovarian cystadenoma 9.9 SELE AREG
4 warthin tumor 9.9 HBEGF ERBB4
5 funisitis 9.8 SELE S100A8
6 diabetic angiopathy 9.7 SELE NOS2
7 gastritis 9.7 S100A8 NOS2 AREG
8 bacterial sepsis 9.6 SELE NOS2
9 paronychia 9.4 PXT1 ERBB4 ERBB3
10 psoriasis 9.2 SELE S100A8 HBEGF AREG
11 childhood medulloblastoma 9.2 ERBB4 ERBB3
12 pancreatic adenocarcinoma 8.9 HBEGF ERBB4 ERBB3 AREG
13 bladder cancer 8.6 HBEGF EREG ERBB4 ERBB3 AREG

Graphical network of the top 20 diseases related to Squamous Blepharitis:



Diseases related to Squamous Blepharitis

Symptoms & Phenotypes for Squamous Blepharitis

MGI Mouse Phenotypes related to Squamous Blepharitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 AREG ERBB3 ERBB4 HBEGF NOS2 SELE
2 integument MP:0010771 9.5 AREG ERBB3 ERBB4 EREG HBEGF NOS2
3 respiratory system MP:0005388 9.02 ERBB3 ERBB4 HBEGF NOS2 SELE

Drugs & Therapeutics for Squamous Blepharitis

Search Clinical Trials , NIH Clinical Center for Squamous Blepharitis

Genetic Tests for Squamous Blepharitis

Anatomical Context for Squamous Blepharitis

MalaCards organs/tissues related to Squamous Blepharitis:

40
Eye, Bone Marrow, Bone

Publications for Squamous Blepharitis

Articles related to Squamous Blepharitis:

# Title Authors PMID Year
1
Ocular toxicities of epidermal growth factor receptor inhibitors and their management. 61
17666986 2007
2
[Anhidrotic ectodermal dysplasia: "congenital ameibomia"]. 61
17568347 2007
3
[Observation on therapeutic effect of squamous blepharitis treated with liquefacient nitrogen cryotherapy]. 61
15301100 2004
4
[Staphylococcus-associated blepharokeratoconjunctivitis. Clinical findings, pathogenesis and therapy]. 61
9181833 1997
5
[Ophthalmologic manifestations in patients with ichthyosis]. 61
1306016 1992
6
Age-related morphological changes in lid margin and meibomian gland anatomy. 61
1424655 1992
7
Manifestations of graft-versus-host disease following allogenic bone marrow transplantation. 61
1821195 1991
8
Effect of methyl cellulose on tear film break-up-time in health and disease. 61
3661141 1987
9
Selsunef ointment to treat squamous blepharitis. 61
14414681 1960

Variations for Squamous Blepharitis

Expression for Squamous Blepharitis

Search GEO for disease gene expression data for Squamous Blepharitis.

Pathways for Squamous Blepharitis

Pathways related to Squamous Blepharitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13 NOS2 HBEGF EREG ERBB4 ERBB3
2
Show member pathways
12.86 HBEGF EREG ERBB4 ERBB3 AREG
3
Show member pathways
12.79 HBEGF EREG ERBB4 ERBB3
4
Show member pathways
12.67 EREG ERBB4 ERBB3 AREG
5 12.4 EREG ERBB4 ERBB3 AREG
6
Show member pathways
12.34 HBEGF EREG ERBB4 ERBB3
7
Show member pathways
12.11 HBEGF EREG ERBB4 ERBB3 AREG
8 12.01 HBEGF ERBB4 ERBB3
9
Show member pathways
11.98 NOS2 ERBB4 ERBB3
10
Show member pathways
11.92 HBEGF EREG ERBB4 ERBB3
11 11.8 EREG ERBB4 ERBB3
12
Show member pathways
11.67 HBEGF EREG ERBB4 ERBB3
13
Show member pathways
11.52 HBEGF EREG ERBB4 ERBB3 AREG
14 11.43 ERBB4 ERBB3 AREG
15
Show member pathways
11.4 SELE NOS2
16 11.38 HBEGF ERBB4
17 11.34 ERBB4 ERBB3
18 11.32 SELE NOS2
19
Show member pathways
11.29 HBEGF EREG ERBB4 ERBB3
20
Show member pathways
11.23 HBEGF EREG AREG
21 11.2 ERBB4 ERBB3

GO Terms for Squamous Blepharitis

Cellular components related to Squamous Blepharitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 S100A8 HBEGF EREG ERBB4 ERBB3 AREG
2 integral component of plasma membrane GO:0005887 9.72 SELE HBEGF EREG ERBB4 ERBB3
3 extracellular space GO:0005615 9.43 SELE S100A8 HBEGF EREG ERBB3 AREG
4 basal plasma membrane GO:0009925 9.37 ERBB4 ERBB3
5 cortical cytoskeleton GO:0030863 9.16 SELE NOS2
6 clathrin-coated vesicle membrane GO:0030665 8.8 HBEGF EREG AREG

Biological processes related to Squamous Blepharitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.77 HBEGF EREG ERBB4 ERBB3 AREG
2 response to lipopolysaccharide GO:0032496 9.7 SELE S100A8 NOS2
3 membrane organization GO:0061024 9.67 HBEGF EREG AREG
4 wound healing GO:0042060 9.65 S100A8 EREG ERBB3
5 MAPK cascade GO:0000165 9.65 HBEGF EREG ERBB4 ERBB3 AREG
6 epidermal growth factor receptor signaling pathway GO:0007173 9.58 HBEGF EREG AREG
7 positive regulation of smooth muscle cell proliferation GO:0048661 9.56 HBEGF EREG
8 response to peptide hormone GO:0043434 9.55 EREG AREG
9 positive regulation of protein kinase B signaling GO:0051897 9.55 HBEGF EREG ERBB4 ERBB3 AREG
10 positive regulation of phosphorylation GO:0042327 9.54 EREG AREG
11 mammary gland alveolus development GO:0060749 9.51 ERBB4 AREG
12 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.5 HBEGF EREG AREG
13 leukocyte migration involved in inflammatory response GO:0002523 9.46 SELE S100A8
14 peptidyl-cysteine S-nitrosylation GO:0018119 9.43 S100A8 NOS2
15 regulation of cell motility GO:2000145 9.26 HBEGF EREG ERBB4 ERBB3
16 ERBB2 signaling pathway GO:0038128 8.92 HBEGF EREG ERBB4 ERBB3

Molecular functions related to Squamous Blepharitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 ERBB4 ERBB3
2 growth factor activity GO:0008083 9.13 HBEGF EREG AREG
3 epidermal growth factor receptor binding GO:0005154 8.92 HBEGF EREG ERBB4 AREG

Sources for Squamous Blepharitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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