MCID: SQM003
MIFTS: 28

Squamous Blepharitis

Categories: Skin diseases

Aliases & Classifications for Squamous Blepharitis

MalaCards integrated aliases for Squamous Blepharitis:

Name: Squamous Blepharitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13825
ICD9CM 34 373.02
SNOMED-CT 67 58912008
ICD10 32 H01.02
UMLS 71 C0155174

Summaries for Squamous Blepharitis

MalaCards based summary : Squamous Blepharitis is related to blepharitis and acneiform dermatitis. An important gene associated with Squamous Blepharitis is BTC (Betacellulin), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Squamous Blepharitis

Graphical network of the top 20 diseases related to Squamous Blepharitis:



Diseases related to Squamous Blepharitis

Symptoms & Phenotypes for Squamous Blepharitis

GenomeRNAi Phenotypes related to Squamous Blepharitis according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.66 NOS2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.66 ERBB3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.66 EGFR
4 Increased shRNA abundance (Z-score > 2) GR00366-A-139 9.66 NTRK1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.66 NTRK1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.66 NOS2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.66 NOS2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.66 NTRK1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.66 EGFR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.66 EGFR
11 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.66 EGFR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 NTRK1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.66 NTRK1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.66 ERBB3 NTRK1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.66 NTRK1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.66 EGFR ERBB3 NTRK1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.66 NOS2
18 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.66 NOS2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.66 EGFR
20 Decreased viability GR00106-A-0 9.61 ERBB3
21 Decreased viability GR00221-A-2 9.61 ERBB3
22 Decreased viability GR00221-A-3 9.61 NTRK1
23 Decreased viability GR00221-A-4 9.61 ERBB3
24 Decreased viability GR00249-S 9.61 NTRK1
25 Decreased viability GR00301-A 9.61 ERBB3 ERBB4 NTRK1
26 Decreased viability GR00342-S-1 9.61 ERBB4
27 Decreased cell viability after pRB stimulation GR00230-A-1 8.85 NTRK1

MGI Mouse Phenotypes related to Squamous Blepharitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.06 AREG BTC EGFR ERBB3 EREG HBEGF
2 cardiovascular system MP:0005385 10.03 AREG BTC EGFR ERBB3 ERBB4 HBEGF
3 immune system MP:0005387 9.97 AREG EGFR ERBB3 ERBB4 EREG NOS2
4 integument MP:0010771 9.97 AREG EGFR ERBB3 ERBB4 EREG HBEGF
5 mortality/aging MP:0010768 9.96 AREG BTC EGFR ERBB3 ERBB4 HBEGF
6 muscle MP:0005369 9.7 BTC EGFR ERBB3 ERBB4 HBEGF NOS2
7 normal MP:0002873 9.56 BTC EGFR ERBB3 ERBB4 EREG HBEGF
8 respiratory system MP:0005388 9.1 EGFR ERBB3 ERBB4 HBEGF NOS2 SELE

Drugs & Therapeutics for Squamous Blepharitis

Search Clinical Trials , NIH Clinical Center for Squamous Blepharitis

Genetic Tests for Squamous Blepharitis

Anatomical Context for Squamous Blepharitis

MalaCards organs/tissues related to Squamous Blepharitis:

40
Bone Marrow

Publications for Squamous Blepharitis

Articles related to Squamous Blepharitis:

# Title Authors PMID Year
1
Ocular toxicities of epidermal growth factor receptor inhibitors and their management. 61
17666986 2007
2
[Anhidrotic ectodermal dysplasia: "congenital ameibomia"]. 61
17568347 2007
3
[Observation on therapeutic effect of squamous blepharitis treated with liquefacient nitrogen cryotherapy]. 61
15301100 2004
4
[Staphylococcus-associated blepharokeratoconjunctivitis. Clinical findings, pathogenesis and therapy]. 61
9181833 1997
5
[Ophthalmologic manifestations in patients with ichthyosis]. 61
1306016 1992
6
Age-related morphological changes in lid margin and meibomian gland anatomy. 61
1424655 1992
7
Manifestations of graft-versus-host disease following allogenic bone marrow transplantation. 61
1821195 1991
8
Effect of methyl cellulose on tear film break-up-time in health and disease. 61
3661141 1987
9
Selsunef ointment to treat squamous blepharitis. 61
14414681 1960

Variations for Squamous Blepharitis

Expression for Squamous Blepharitis

Search GEO for disease gene expression data for Squamous Blepharitis.

Pathways for Squamous Blepharitis

Pathways related to Squamous Blepharitis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 S100A8 NOS2 HBEGF EREG ERBB4 ERBB3
2
Show member pathways
13.67 NTRK1 NOS2 HBEGF ERBB4 ERBB3 EGFR
3
Show member pathways
13.55 NTRK1 HBEGF ERBB4 ERBB3 EGFR BTC
4
Show member pathways
13.42 NTRK1 HBEGF ERBB4 ERBB3 EGFR BTC
5
Show member pathways
13.39 NTRK1 ERBB4 ERBB3 EGFR BTC AREG
6
Show member pathways
13.35 HBEGF EREG ERBB4 ERBB3 EGFR BTC
7
Show member pathways
13.31 HBEGF EREG ERBB4 ERBB3 EGFR BTC
8
Show member pathways
13.27 NTRK1 ERBB4 ERBB3 EGFR BTC AREG
9
Show member pathways
13.25 NOS2 HBEGF EREG ERBB4 ERBB3 EGFR
10
Show member pathways
13.19 NTRK1 HBEGF ERBB4 ERBB3 EGFR BTC
11
Show member pathways
13.15 NTRK1 HBEGF EGFR BTC AREG
12
Show member pathways
13.15 NTRK1 ERBB4 ERBB3 EGFR BTC AREG
13
Show member pathways
13.09 HBEGF EREG ERBB4 ERBB3 EGFR BTC
14
Show member pathways
12.97 NTRK1 HBEGF EREG ERBB4 ERBB3 EGFR
15
Show member pathways
12.95 NTRK1 HBEGF EGFR BTC AREG
16
Show member pathways
12.93 NTRK1 HBEGF EGFR BTC AREG
17
Show member pathways
12.89 NTRK1 EREG ERBB4 ERBB3 EGFR AREG
18
Show member pathways
12.81 NTRK1 ERBB4 ERBB3 EGFR
19
Show member pathways
12.73 NTRK1 ERBB4 ERBB3 EGFR
20
Show member pathways
12.73 NTRK1 EREG EGFR AREG
21 12.65 NTRK1 EREG ERBB4 ERBB3 EGFR AREG
22
Show member pathways
12.59 HBEGF EREG ERBB4 ERBB3 EGFR BTC
23
Show member pathways
12.36 NTRK1 ERBB4 ERBB3 EGFR
24
Show member pathways
12.36 HBEGF EREG ERBB4 ERBB3 EGFR BTC
25 12.31 NTRK1 NOS2 ERBB4 ERBB3 EGFR
26
Show member pathways
12.3 NTRK1 ERBB4 ERBB3 EGFR BTC AREG
27 12.22 HBEGF ERBB4 ERBB3 EGFR
28
Show member pathways
12.19 NTRK1 HBEGF EGFR BTC AREG
29
Show member pathways
12.13 NTRK1 ERBB4 ERBB3 EGFR
30
Show member pathways
12.1 HBEGF EREG ERBB4 ERBB3 EGFR BTC
31 12 NTRK1 EREG ERBB4 ERBB3 EGFR
32
Show member pathways
11.93 ERBB4 ERBB3 EGFR
33
Show member pathways
11.75 HBEGF EREG ERBB4 ERBB3 EGFR BTC
34 11.58 HBEGF ERBB4 EGFR
35 11.57 NTRK1 ERBB4 ERBB3 EGFR BTC AREG
36 11.54 ERBB4 ERBB3 EGFR
37
Show member pathways
11.54 HBEGF EREG ERBB4 ERBB3 EGFR BTC
38
Show member pathways
11.47 HBEGF EREG ERBB4 ERBB3 EGFR BTC
39
Show member pathways
11.46 HBEGF EREG EGFR BTC AREG
40 11.41 NTRK1 ERBB4 ERBB3 EGFR
41 11.18 ERBB3 EGFR
42
Show member pathways
11.09 HBEGF EGFR
43 10.93 NTRK1 ERBB4 ERBB3 EGFR BTC AREG

GO Terms for Squamous Blepharitis

Cellular components related to Squamous Blepharitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.21 SELE S100A8 NTRK1 HBEGF EREG ERBB4
2 integral component of membrane GO:0016021 10.09 SELE NTRK1 HBEGF EREG ERBB4 ERBB3
3 plasma membrane GO:0005886 10.02 SELE S100A8 NTRK1 NOS2 HBEGF EREG
4 extracellular region GO:0005576 9.86 S100A8 HBEGF EREG ERBB4 ERBB3 EGFR
5 cell surface GO:0009986 9.78 NTRK1 HBEGF EGFR AREG
6 receptor complex GO:0043235 9.71 NTRK1 ERBB4 ERBB3 EGFR
7 integral component of plasma membrane GO:0005887 9.7 SELE NTRK1 HBEGF EREG ERBB4 ERBB3
8 basolateral plasma membrane GO:0016323 9.67 ERBB4 ERBB3 EGFR
9 extracellular space GO:0005615 9.56 SELE S100A8 HBEGF EREG ERBB3 EGFR
10 basal plasma membrane GO:0009925 9.54 ERBB4 ERBB3 EGFR
11 cortical cytoskeleton GO:0030863 9.46 SELE NOS2
12 clathrin-coated vesicle membrane GO:0030665 9.02 HBEGF EREG EGFR BTC AREG

Biological processes related to Squamous Blepharitis according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.11 HBEGF EREG ERBB4 ERBB3 EGFR BTC
2 multicellular organism development GO:0007275 10.03 NTRK1 EREG ERBB4 ERBB3 EGFR
3 positive regulation of cell proliferation GO:0008284 9.98 HBEGF EREG ERBB4 ERBB3 EGFR BTC
4 phosphorylation GO:0016310 9.97 NTRK1 ERBB4 ERBB3 EGFR
5 protein phosphorylation GO:0006468 9.95 NTRK1 ERBB4 ERBB3 EGFR
6 negative regulation of apoptotic process GO:0043066 9.92 NTRK1 ERBB4 EGFR BTC
7 MAPK cascade GO:0000165 9.87 HBEGF EREG ERBB4 ERBB3 EGFR BTC
8 membrane organization GO:0061024 9.85 HBEGF EREG EGFR BTC AREG
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.83 NTRK1 ERBB4 EGFR
10 peptidyl-tyrosine phosphorylation GO:0018108 9.83 NTRK1 ERBB4 ERBB3 EGFR
11 positive regulation of protein phosphorylation GO:0001934 9.82 NTRK1 ERBB4 EGFR
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.81 NTRK1 ERBB4 ERBB3 EGFR
13 wound healing GO:0042060 9.8 S100A8 EREG ERBB3 EGFR
14 protein autophosphorylation GO:0046777 9.79 NTRK1 ERBB4 EGFR
15 response to lipopolysaccharide GO:0032496 9.79 SELE S100A8 NOS2
16 positive regulation of kinase activity GO:0033674 9.78 NTRK1 ERBB4 ERBB3 EGFR
17 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 NTRK1 ERBB4 ERBB3
18 epidermal growth factor receptor signaling pathway GO:0007173 9.77 HBEGF EREG EGFR BTC AREG
19 positive regulation of cell growth GO:0030307 9.76 S100A8 HBEGF EGFR
20 circadian rhythm GO:0007623 9.75 NTRK1 NOS2 EGFR
21 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 HBEGF EREG EGFR
22 positive regulation of phosphorylation GO:0042327 9.71 EREG EGFR AREG
23 positive regulation of epidermal growth factor-activated receptor activity GO:0045741 9.71 HBEGF EREG BTC AREG
24 positive regulation of protein kinase B signaling GO:0051897 9.7 HBEGF EREG ERBB4 ERBB3 EGFR BTC
25 negative regulation of protein catabolic process GO:0042177 9.67 NOS2 EGFR
26 peptidyl-tyrosine autophosphorylation GO:0038083 9.66 NTRK1 EGFR
27 activation of phospholipase C activity GO:0007202 9.65 SELE EGFR
28 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.65 HBEGF EREG EGFR BTC AREG
29 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.64 NTRK1 EGFR
30 positive regulation of mitotic nuclear division GO:0045840 9.64 EREG BTC
31 positive regulation of DNA replication GO:0045740 9.63 EREG EGFR
32 mammary gland alveolus development GO:0060749 9.61 ERBB4 AREG
33 leukocyte migration involved in inflammatory response GO:0002523 9.6 SELE S100A8
34 peptidyl-cysteine S-nitrosylation GO:0018119 9.55 S100A8 NOS2
35 regulation of cell motility GO:2000145 9.43 HBEGF EREG ERBB4 ERBB3 EGFR BTC
36 ERBB2 signaling pathway GO:0038128 9.1 HBEGF EREG ERBB4 ERBB3 EGFR BTC

Molecular functions related to Squamous Blepharitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.67 NTRK1 ERBB4 ERBB3 EGFR
2 protein kinase activity GO:0004672 9.62 NTRK1 ERBB4 ERBB3 EGFR
3 growth factor activity GO:0008083 9.56 HBEGF EREG BTC AREG
4 protein tyrosine kinase activity GO:0004713 9.46 NTRK1 ERBB4 ERBB3 EGFR
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 NTRK1 ERBB4 ERBB3 EGFR
6 epidermal growth factor receptor binding GO:0005154 9.02 HBEGF EREG ERBB4 BTC AREG

Sources for Squamous Blepharitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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