MCID: SQM004
MIFTS: 26

Squamous Cell Bile Duct Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Squamous Cell Bile Duct Carcinoma

MalaCards integrated aliases for Squamous Cell Bile Duct Carcinoma:

Name: Squamous Cell Bile Duct Carcinoma 12 15
Bile Duct Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5537
NCIt 50 C5777
UMLS 70 C0861861

Summaries for Squamous Cell Bile Duct Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the bile duct.

MalaCards based summary : Squamous Cell Bile Duct Carcinoma, also known as bile duct squamous cell carcinoma, is related to idiopathic corneal edema and pinguecula. An important gene associated with Squamous Cell Bile Duct Carcinoma is TKFC (Triokinase And FMN Cyclase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include bile duct, breast and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Squamous Cell Bile Duct Carcinoma

Diseases related to Squamous Cell Bile Duct Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 idiopathic corneal edema 10.3 KRT8 KRT19
2 pinguecula 10.3 KRT19 KRT14
3 limbal stem cell deficiency 10.3 KRT19 KRT14
4 polyp of corpus uteri 10.3 KRT8 KRT14
5 myoepithelioma 10.2 KRT18 KRT14
6 salpingitis isthmica nodosa 10.2 KRT8 KRT14
7 glomangiomatosis 10.2 TKFC KRT18
8 rete ovarii adenoma 10.2 KRT8 KRT14
9 rete ovarii benign neoplasm 10.2 KRT8 KRT14
10 breast adenomyoepithelioma 10.2 KRT5 KRT14
11 neurenteric cyst 10.2 KRT8 KRT18
12 barre-lieou syndrome 10.2 GIP DPP4
13 micronodular basal cell carcinoma 10.2 KRT5 KRT14
14 breast myoepithelial neoplasm 10.2 KRT5 KRT14
15 breast myoepithelial carcinoma 10.2 KRT5 KRT14
16 nuclear senile cataract 10.2 MT-CO1 GIP
17 adhesive otitis media 10.2 KRT8 KRT18
18 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
19 lipid-rich carcinoma 10.2 KRT5 KRT14
20 cryptogenic cirrhosis 10.2 KRT8 KRT18
21 sarcomatoid squamous cell skin carcinoma 10.2 KRT8 KRT5
22 intracystic papillary adenoma 10.2 KRT5 KRT14
23 synchronous bilateral breast carcinoma 10.1 KRT5 KRT14
24 splenic tuberculosis 10.1 KRT19 CRP
25 diffuse palmoplantar keratoderma 10.1 MT-CO1 KRT5
26 hair follicle neoplasm 10.1 KRT5 KRT14
27 epidermolysis bullosa simplex, localized 10.1 KRT5 KRT14
28 epidermolysis bullosa simplex, generalized 10.1 KRT5 KRT14
29 bartonellosis 10.0 MT-CO1 CRP
30 renal pelvis adenocarcinoma 10.0 KRT7 KRT19
31 sebaceous adenocarcinoma 10.0 KRT5 KRT14
32 syringoma 10.0 KRT7 KRT19
33 renal pelvis squamous cell carcinoma 10.0 KRT5 CRP
34 anal canal adenocarcinoma 10.0 KRT7 KRT19
35 chronic meningitis 10.0 MT-CO1 CRP
36 pulmonary artery leiomyosarcoma 10.0 KRT7 KRT19
37 haemophilus meningitis 10.0 MT-CO1 CRP
38 ovarian germ cell teratoma 10.0 KRT7 KRT19
39 adenofibroma 10.0 KRT7 KRT19
40 biliary tract benign neoplasm 10.0 KRT7 KRT19
41 epidermolysis bullosa simplex with mottled pigmentation 10.0 KRT5 KRT14
42 oncocytic breast carcinoma 10.0 KRT7 KRT14
43 epidermolysis bullosa simplex 10.0 KRT5 KRT19 KRT14
44 mixed fibrolamellar hepatocellular carcinoma 10.0 KRT7 KRT19
45 endolymphatic sac tumor 10.0 KRT8 KRT7
46 balanitis 10.0 DPP4 CRP
47 bile duct cysts 10.0 KRT7 KRT19
48 synovium neoplasm 10.0 KRT8 KRT7
49 eccrine porocarcinoma 10.0 KRT7 KRT19
50 adenosquamous bile duct carcinoma 10.0 MT-CO1 GIP DPP4

Graphical network of the top 20 diseases related to Squamous Cell Bile Duct Carcinoma:



Diseases related to Squamous Cell Bile Duct Carcinoma

Symptoms & Phenotypes for Squamous Cell Bile Duct Carcinoma

GenomeRNAi Phenotypes related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.44 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.44 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.44 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.44 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.44 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.44 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.44 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.44 KRT18

Drugs & Therapeutics for Squamous Cell Bile Duct Carcinoma

Search Clinical Trials , NIH Clinical Center for Squamous Cell Bile Duct Carcinoma

Genetic Tests for Squamous Cell Bile Duct Carcinoma

Anatomical Context for Squamous Cell Bile Duct Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Squamous Cell Bile Duct Carcinoma:

19
Bile Duct

MalaCards organs/tissues related to Squamous Cell Bile Duct Carcinoma:

40
Breast, Liver, Skin, Lung, Eye, Thymus, Heart

Publications for Squamous Cell Bile Duct Carcinoma

Articles related to Squamous Cell Bile Duct Carcinoma:

# Title Authors PMID Year
1
LacCur stain for detection of mucin in adenocarcinoma. 61
14971540 2004

Variations for Squamous Cell Bile Duct Carcinoma

Expression for Squamous Cell Bile Duct Carcinoma

Search GEO for disease gene expression data for Squamous Cell Bile Duct Carcinoma.

Pathways for Squamous Cell Bile Duct Carcinoma

Pathways related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
2 12.04 KRT8 KRT7 KRT5 KRT19 KRT18
3
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
4 11.68 KRT19 KRT18 KRT14
5 11.42 KRT19 KRT18 KRT14
6
Show member pathways
11.13 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
7 10.95 KRT8 KRT19

GO Terms for Squamous Cell Bile Duct Carcinoma

Cellular components related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 TKFC KRT8 KRT7 KRT5 KRT19 KRT18
2 cell periphery GO:0071944 9.46 KRT8 KRT19 KRT18 KRT14
3 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
4 costamere GO:0043034 9.37 KRT8 KRT19
5 keratin filament GO:0045095 9.35 KRT8 KRT7 KRT5 KRT18 KRT14
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 intermediate filament GO:0005882 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Biological processes related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT8 KRT7 KRT19 KRT18
2 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 sarcomere organization GO:0045214 9.4 KRT8 KRT19
4 hemidesmosome assembly GO:0031581 9.32 KRT5 KRT14
5 hepatocyte apoptotic process GO:0097284 9.26 KRT8 KRT18
6 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
7 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 KRT19 KRT18 KRT14
2 structural constituent of cytoskeleton GO:0005200 9.13 KRT5 KRT19 KRT14
3 scaffold protein binding GO:0097110 8.8 KRT8 KRT5 KRT18

Sources for Squamous Cell Bile Duct Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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