MCID: SQM004
MIFTS: 25

Squamous Cell Bile Duct Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Squamous Cell Bile Duct Carcinoma

MalaCards integrated aliases for Squamous Cell Bile Duct Carcinoma:

Name: Squamous Cell Bile Duct Carcinoma 12 15
Bile Duct Squamous Cell Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5537
NCIt 49 C5777
UMLS 71 C0861861

Summaries for Squamous Cell Bile Duct Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the bile duct.

MalaCards based summary : Squamous Cell Bile Duct Carcinoma, also known as bile duct squamous cell carcinoma, is related to squamous cell carcinoma and idiopathic corneal edema. An important gene associated with Squamous Cell Bile Duct Carcinoma is TKFC (Triokinase And FMN Cyclase), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. Affiliated tissues include bile duct, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Squamous Cell Bile Duct Carcinoma

Diseases related to Squamous Cell Bile Duct Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 264)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.8 KRT7 KRT19 KRT14 CEACAM5
2 idiopathic corneal edema 10.4 KRT8 KRT19
3 pinguecula 10.4 KRT19 KRT14
4 limbal stem cell deficiency 10.4 KRT19 KRT14
5 polyp of corpus uteri 10.3 KRT8 KRT14
6 neurenteric cyst 10.3 KRT8 KRT18
7 glomangiomatosis 10.3 TKFC KRT18
8 bone benign neoplasm 10.3 KRT19 KRT14
9 breast adenomyoepithelioma 10.3 KRT5 KRT14
10 salpingitis isthmica nodosa 10.3 KRT8 KRT14
11 cryptogenic cirrhosis 10.3 KRT8 KRT18
12 eccrine papillary adenoma 10.3 KRT14 CEACAM5
13 laryngeal mucoepidermoid carcinoma 10.3 KRT14 CEACAM5
14 fibroepithelial basal cell carcinoma 10.2 KRT14 CEACAM5
15 breast myoepithelial neoplasm 10.2 KRT5 KRT14
16 paratesticular lipoma 10.2 KRT19 CEACAM5
17 lipoma of spermatic cord 10.2 KRT19 CEACAM5
18 breast metaplastic carcinoma 10.2 KRT5 KRT14
19 epidermolysis bullosa simplex, autosomal recessive 1 10.2 KRT5 KRT14
20 villous adenoma 10.2 KRT8 CEACAM5
21 micronodular basal cell carcinoma 10.2 KRT5 KRT14
22 lymphoepithelioma-like thymic carcinoma 10.2 KRT8 KRT5
23 breast myoepithelial carcinoma 10.2 KRT5 KRT14
24 lipid-rich carcinoma 10.2 KRT5 KRT14
25 pericardial mesothelioma 10.2 KRT5 KRT19
26 colon neuroendocrine neoplasm 10.2 KRT19 CEACAM5
27 adhesive otitis media 10.2 KRT8 KRT18
28 spiradenoma 10.2 KRT7 KRT14
29 intrahepatic bile duct adenoma 10.2 KRT7 KRT19
30 bile duct adenoma 10.2 KRT7 KRT19
31 adenofibroma 10.2 KRT7 KRT19
32 epidermolysis bullosa simplex, localized 10.2 KRT5 KRT14
33 oncocytic breast carcinoma 10.2 KRT7 KRT14
34 anal canal adenocarcinoma 10.2 KRT7 KRT19
35 pulmonary artery leiomyosarcoma 10.2 KRT7 KRT19
36 reticulate acropigmentation of kitamura 10.1 KRT5 KRT14
37 endolymphatic sac tumor 10.1 KRT8 KRT7
38 ovarian germ cell teratoma 10.1 KRT7 KRT19
39 epidermolysis bullosa simplex, generalized 10.1 KRT5 KRT14
40 mixed fibrolamellar hepatocellular carcinoma 10.1 KRT7 KRT19
41 synovium neoplasm 10.1 KRT8 KRT7
42 epidermolysis bullosa simplex with mottled pigmentation 10.1 KRT5 KRT14
43 mucoepidermoid esophageal carcinoma 10.1 KRT5 CEACAM5
44 breast cystic hypersecretory carcinoma 10.1 KRT5 CEACAM5
45 gallbladder squamous cell carcinoma 10.1 KRT5 CEACAM5
46 struma ovarii 10.1 KRT7 KRT19
47 thymus adenocarcinoma 10.1 KRT5 CEACAM5
48 lipid-rich breast carcinoma 10.1 KRT5 CEACAM5
49 vulva basal cell carcinoma 10.1 KRT5 CEACAM5
50 monophasic synovial sarcoma 10.1 KRT7 KRT19

Graphical network of the top 20 diseases related to Squamous Cell Bile Duct Carcinoma:



Diseases related to Squamous Cell Bile Duct Carcinoma

Symptoms & Phenotypes for Squamous Cell Bile Duct Carcinoma

GenomeRNAi Phenotypes related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-124 9.44 KRT18
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.44 KRT18
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.44 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.44 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.44 KRT18
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.44 KRT5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.44 KRT8
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.44 KRT18
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.44 KRT18 KRT5 KRT7 KRT8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.44 KRT18

Drugs & Therapeutics for Squamous Cell Bile Duct Carcinoma

Search Clinical Trials , NIH Clinical Center for Squamous Cell Bile Duct Carcinoma

Genetic Tests for Squamous Cell Bile Duct Carcinoma

Anatomical Context for Squamous Cell Bile Duct Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Squamous Cell Bile Duct Carcinoma:

19
Bile Duct

Publications for Squamous Cell Bile Duct Carcinoma

Articles related to Squamous Cell Bile Duct Carcinoma:

# Title Authors PMID Year
1
LacCur stain for detection of mucin in adenocarcinoma. 61
14971540 2004

Variations for Squamous Cell Bile Duct Carcinoma

Cosmic variations for Squamous Cell Bile Duct Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM91859716 biliary tract,bile duct,carcinoma,squamous cell carcinoma c.35G>A p.G12D 12:25245350-25245350 0

Expression for Squamous Cell Bile Duct Carcinoma

Search GEO for disease gene expression data for Squamous Cell Bile Duct Carcinoma.

Pathways for Squamous Cell Bile Duct Carcinoma

Pathways related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
2 12.04 KRT8 KRT7 KRT5 KRT19 KRT18
3
Show member pathways
11.89 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
4 11.42 KRT19 KRT18 KRT14
5
Show member pathways
11.13 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
6 10.91 KRT8 KRT19

GO Terms for Squamous Cell Bile Duct Carcinoma

Cellular components related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.81 TKFC KRT8 KRT7 KRT5 KRT19 KRT18
2 cell periphery GO:0071944 9.56 KRT8 KRT19 KRT18 KRT14
3 apicolateral plasma membrane GO:0016327 9.4 KRT8 KRT19
4 costamere GO:0043034 9.37 KRT8 KRT19
5 keratin filament GO:0045095 9.35 KRT8 KRT7 KRT5 KRT18 KRT14
6 dystrophin-associated glycoprotein complex GO:0016010 9.32 KRT8 KRT19
7 intermediate filament GO:0005882 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Biological processes related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.67 KRT8 KRT7 KRT19 KRT18
2 keratinization GO:0031424 9.43 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14
3 hemidesmosome assembly GO:0031581 9.32 KRT5 KRT14
4 hepatocyte apoptotic process GO:0097284 9.26 KRT8 KRT18
5 cell differentiation involved in embryonic placenta development GO:0060706 9.16 KRT8 KRT19
6 cornification GO:0070268 9.1 KRT8 KRT7 KRT5 KRT19 KRT18 KRT14

Molecular functions related to Squamous Cell Bile Duct Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10 TKFC MT-CO1 KRT8 KRT7 KRT5 KRT19
2 structural molecule activity GO:0005198 9.33 KRT19 KRT18 KRT14
3 structural constituent of cytoskeleton GO:0005200 9.13 KRT5 KRT19 KRT14
4 scaffold protein binding GO:0097110 8.8 KRT8 KRT5 KRT18

Sources for Squamous Cell Bile Duct Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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