MCID: SQM018
MIFTS: 24

Squamous Cell Carcinoma of the Oral Tongue

Categories: Rare diseases, Oral diseases, Cancer diseases

Aliases & Classifications for Squamous Cell Carcinoma of the Oral Tongue

MalaCards integrated aliases for Squamous Cell Carcinoma of the Oral Tongue:

Name: Squamous Cell Carcinoma of the Oral Tongue 59
Oral Tongue Squamous Cell Carcinoma 59
Otscc 59

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the oral tongue
Inheritance: Not applicable;

Classifications:



External Ids:

Orphanet 59 ORPHA457252

Summaries for Squamous Cell Carcinoma of the Oral Tongue

MalaCards based summary : Squamous Cell Carcinoma of the Oral Tongue, also known as oral tongue squamous cell carcinoma, is related to squamous cell carcinoma and oral leukoplakia. An important gene associated with Squamous Cell Carcinoma of the Oral Tongue is CCND1 (Cyclin D1), and among its related pathways/superpathways are Pathways in cancer and FGF signaling pathway. Affiliated tissues include tongue, and related phenotypes are cellular and integument

Related Diseases for Squamous Cell Carcinoma of the Oral Tongue

Diseases related to Squamous Cell Carcinoma of the Oral Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 28.5 CCND1 CDH1 DCUN1D1 MKI67 PIK3CA
2 oral leukoplakia 10.6 CCND1 MKI67
3 hidradenocarcinoma 10.6 CCND1 MKI67
4 polymorphous low-grade adenocarcinoma 10.6 CCND1 MKI67
5 keratocystic odontogenic tumor 10.6 CCND1 MKI67
6 steatocystoma multiplex 10.4 KRT10 KRT16
7 discoid lupus erythematosus 10.4 KRT10 KRT16
8 pinguecula 10.4 KRT10 KRT16
9 pachyonychia congenita 1 10.3 KRT10 KRT16
10 white sponge nevus 1 10.3 KRT10 KRT16
11 pre-malignant neoplasm 10.2 CCND1 CDH1
12 primary cutaneous amyloidosis 10.2 KRT10 KRT16
13 gastrointestinal system benign neoplasm 10.2 CCND1 CDH1
14 intestinal benign neoplasm 10.2 CCND1 CDH1
15 ethmoid sinus cancer 10.1 CCND1 PIK3CA
16 ichthyosis bullosa of siemens 10.1 KRT10 KRT16
17 ethmoid sinus adenocarcinoma 10.1 CCND1 PIK3CA
18 hemimegalencephaly 10.1 CCND1 PIK3CA
19 pancreatic neuroendocrine tumor 10.1 MKI67 PIK3CA
20 bowen's disease 10.0 KRT10 KRT16 MKI67
21 keratoacanthoma 10.0 KRT10 KRT16 MKI67
22 pharynx cancer 10.0 CCND1 CDH1
23 breast squamous cell carcinoma 10.0 KRT10 PIK3CA
24 basal cell carcinoma 9.9 KRT10 KRT16 MKI67
25 skin disease 9.9 KRT10 KRT16 LAMC2
26 barrett esophagus 9.9 CCND1 CDH1 MKI67
27 fanconi anemia, complementation group a 9.9
28 giant cell tumor 9.9
29 cervicitis 9.9
30 keratosis, seborrheic 9.9 KRT10 PIK3CA
31 breast adenomyoepithelioma 9.7 CDH1 PIK3CA
32 breast myoepithelial neoplasm 9.7 CDH1 PIK3CA
33 parotid gland cancer 9.7 CDH1 PIK3CA
34 epstein-barr virus-associated gastric carcinoma 9.6 CDH1 PIK3CA
35 epidermolytic hyperkeratosis 9.6 KRT10 KRT16
36 ovarian cancer 1 9.5 CDH1 PIK3CA
37 malignant ovarian surface epithelial-stromal neoplasm 9.5 CDH1 PIK3CA
38 ovary epithelial cancer 9.5 CDH1 PIK3CA
39 female reproductive organ cancer 9.4 CCND1 CDH1 PIK3CA
40 bile duct carcinoma 9.4 CCND1 CDH1 PIK3CA
41 respiratory system cancer 9.4 CCND1 CDH1 PIK3CA
42 gastrointestinal system cancer 9.4 CCND1 CDH1 PIK3CA
43 pancreas adenocarcinoma 9.4 CCND1 CDH1 PIK3CA
44 bladder urothelial carcinoma 9.4 CCND1 CDH1 PIK3CA
45 anaplastic thyroid cancer 9.4 CDH1 PIK3CA
46 adamantinoma of long bones 9.3 CCND1 CDH1 PIK3CA
47 squamous cell carcinoma, head and neck 9.3 CCND1 CDH1 PIK3CA
48 urinary tract obstruction 9.2 CDH1 PIK3CA
49 adenocarcinoma 9.2 CCND1 CDH1 PIK3CA
50 lung cancer susceptibility 3 9.2 CCND1 CDH1 PIK3CA

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Oral Tongue:



Diseases related to Squamous Cell Carcinoma of the Oral Tongue

Symptoms & Phenotypes for Squamous Cell Carcinoma of the Oral Tongue

MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Oral Tongue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.5 CCND1 CDH1 FABP5 KIF2A KRT16 LAMC2
2 integument MP:0010771 9.1 CCND1 CDH1 FABP5 KRT16 LAMC2 PIK3CA

Drugs & Therapeutics for Squamous Cell Carcinoma of the Oral Tongue

Search Clinical Trials , NIH Clinical Center for Squamous Cell Carcinoma of the Oral Tongue

Genetic Tests for Squamous Cell Carcinoma of the Oral Tongue

Anatomical Context for Squamous Cell Carcinoma of the Oral Tongue

MalaCards organs/tissues related to Squamous Cell Carcinoma of the Oral Tongue:

41
Tongue

Publications for Squamous Cell Carcinoma of the Oral Tongue

Articles related to Squamous Cell Carcinoma of the Oral Tongue:

# Title Authors Year
1
T4 squamous cell carcinoma of the oral tongue without mandibular involvement: surgery or chemoradiotherapy? ( 24275355 )
2014
2
Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. ( 24248467 )
2014
3
Squamous cell carcinoma of the oral tongue in a patient with Fanconi anemia treated with radiotherapy and concurrent cetuximab: a case report and review of the literature. ( 22965917 )
2013
4
Aggressive squamous cell carcinoma of the oral tongue in a woman with metastatic giant cell tumor treated with pegylated liposomal doxorubicin. ( 23263922 )
2012
5
Metastasis of squamous cell carcinoma of the oral tongue is associated with down-regulation of epidermal fatty acid binding protein (E-FABP). ( 16759896 )
2007
6
Correlation of clinical, histological, and cytokeratin profiles of squamous cell carcinoma of the oral tongue with prognosis. ( 17913944 )
2007
7
Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. ( 14734465 )
2004
8
The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. ( 12796399 )
2003

Variations for Squamous Cell Carcinoma of the Oral Tongue

Cosmic variations for Squamous Cell Carcinoma of the Oral Tongue:

9
(show top 50) (show all 202)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957917 TSC2 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 9
2 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 9
3 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 9
4 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 9
5 COSM10771 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 9
6 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 9
7 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
8 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 9
9 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 9
10 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 9
11 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 9
12 COSM11089 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.584T>C p.I195T 17:7674947-7674947 9
13 COSM43903 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.470T>G p.V157G 17:7675142-7675142 9
14 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 9
15 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 9
16 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 17:7674944-7674944 9
17 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 9
18 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 9
19 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 9
20 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 17:7673748-7673748 9
21 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 17:7674972-7674972 9
22 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
23 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 17:7674941-7674941 9
24 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 9
25 COSM44785 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.702C>G p.Y234* 17:7674261-7674261 9
26 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 17:7674887-7674887 9
27 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 17:7674884-7674884 9
28 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 9
29 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 17:7674923-7674923 9
30 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 9
31 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 17:7673811-7673811 9
32 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 9
33 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
34 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 17:7673812-7673812 9
35 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 17:7673839-7673839 9
36 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 9
37 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 9
38 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 17:7674291-7674291 9
39 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 17:7673806-7673806 9
40 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 9
41 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 17:7673776-7673776 9
42 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 17:7675131-7675131 9
43 COSM11147 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.370T>C p.C124R 17:7675999-7675999 9
44 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 9
45 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 17:7675995-7675995 9
46 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 9
47 COSM10645 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 9
48 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 17:7675085-7675085 9
49 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 9
50 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 17:7675174-7675174 9

Expression for Squamous Cell Carcinoma of the Oral Tongue

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Oral Tongue.

Pathways for Squamous Cell Carcinoma of the Oral Tongue

Pathways related to Squamous Cell Carcinoma of the Oral Tongue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 CCND1 CDH1 LAMC2 PIK3CA
2 11.1 CDH1 PIK3CA
3 11.1 CCND1 LAMC2 PIK3CA
4 10.91 CCND1 PIK3CA
5 10.86 CDH1 PIK3CA
6 10.72 CDH1 PIK3CA
7 10.43 CDH1 PIK3CA
8 10.32 CCND1 CDH1 PIK3CA

GO Terms for Squamous Cell Carcinoma of the Oral Tongue

Biological processes related to Squamous Cell Carcinoma of the Oral Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epidermis development GO:0008544 8.8 FABP5 KRT16 LAMC2

Sources for Squamous Cell Carcinoma of the Oral Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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