OTSCC
MCID: SQM018
MIFTS: 31

Squamous Cell Carcinoma of the Oral Tongue (OTSCC)

Categories: Cancer diseases, Oral diseases, Rare diseases

Aliases & Classifications for Squamous Cell Carcinoma of the Oral Tongue

MalaCards integrated aliases for Squamous Cell Carcinoma of the Oral Tongue:

Name: Squamous Cell Carcinoma of the Oral Tongue 59
Oral Tongue Squamous Cell Carcinoma 59
Otscc 59

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the oral tongue
Inheritance: Not applicable;

Classifications:



External Ids:

Orphanet 59 ORPHA457252

Summaries for Squamous Cell Carcinoma of the Oral Tongue

MalaCards based summary : Squamous Cell Carcinoma of the Oral Tongue, also known as oral tongue squamous cell carcinoma, is related to squamous cell carcinoma and pre-malignant neoplasm. An important gene associated with Squamous Cell Carcinoma of the Oral Tongue is CCND1 (Cyclin D1), and among its related pathways/superpathways are Pathways in cancer and FGF signaling pathway. Affiliated tissues include tongue, lung and bone, and related phenotypes are cellular and integument

Related Diseases for Squamous Cell Carcinoma of the Oral Tongue

Diseases related to Squamous Cell Carcinoma of the Oral Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 30.2 CCND1 CDH1 DCUN1D1 MKI67 PIK3CA
2 pre-malignant neoplasm 10.2 CCND1 CDH1
3 verrucous carcinoma 10.2 CCND1 KRT10
4 laryngeal disease 10.2 CCND1 CDH1
5 oropharynx cancer 10.2 CCND1 CDH1
6 pharynx cancer 10.2 CCND1 CDH1
7 steatocystoma multiplex 10.2 KRT10 KRT16
8 discoid lupus erythematosus 10.1 KRT10 KRT16
9 pinguecula 10.1 KRT10 KRT16
10 nasopharyngeal disease 10.1 CCND1 CDH1
11 white sponge nevus 1 10.1 KRT10 KRT16
12 palmoplantar keratoderma, epidermolytic 10.1 KRT10 KRT16
13 pachyonychia congenita 1 10.1 KRT10 KRT16
14 hidradenocarcinoma 10.1 CCND1 MKI67
15 polymorphous low-grade adenocarcinoma 10.1 CCND1 MKI67
16 keratocystic odontogenic tumor 10.1 CCND1 MKI67
17 primary cutaneous amyloidosis 10.1 KRT10 KRT16
18 tongue squamous cell carcinoma 10.1
19 inverted papilloma 10.0 CCND1 MKI67
20 cervix disease 10.0 CCND1 CDH1
21 fanconi anemia, complementation group a 10.0
22 giant cell tumor 10.0
23 ethmoid sinus cancer 10.0 CCND1 PIK3CA
24 ethmoid sinus adenocarcinoma 10.0 CCND1 PIK3CA
25 hemimegalencephaly 10.0 CCND1 PIK3CA
26 breast adenomyoepithelioma 10.0 CDH1 PIK3CA
27 breast myoepithelial neoplasm 10.0 CDH1 PIK3CA
28 breast squamous cell carcinoma 10.0 KRT10 PIK3CA
29 papilloma 10.0
30 ductal carcinoma in situ 10.0 CCND1 CDH1 MKI67
31 keratosis, seborrheic 10.0 KRT10 PIK3CA
32 skin disease 10.0 KRT10 KRT16 LAMC2
33 epstein-barr virus-associated gastric carcinoma 10.0 CDH1 PIK3CA
34 penile cancer 10.0 CCND1 PIK3CA
35 bowen's disease 9.9 KRT10 KRT16 MKI67
36 keratoacanthoma 9.9 KRT10 KRT16 MKI67
37 pancreatic neuroendocrine tumor 9.9 MKI67 PIK3CA
38 ovarian cancer 1 9.9 CDH1 PIK3CA
39 basal cell carcinoma 9.9 KRT10 KRT16 MKI67
40 uterine anomalies 9.9 CCND1 CDH1 PIK3CA
41 respiratory system cancer 9.9 CCND1 CDH1 PIK3CA
42 intestinal disease 9.9 CCND1 CDH1 PIK3CA
43 gastrointestinal system cancer 9.9 CCND1 CDH1 PIK3CA
44 pancreas adenocarcinoma 9.9 CCND1 CDH1 PIK3CA
45 adenocarcinoma 9.9 CCND1 CDH1 PIK3CA
46 malignant ovarian surface epithelial-stromal neoplasm 9.9 CDH1 PIK3CA
47 bladder urothelial carcinoma 9.9 CCND1 CDH1 PIK3CA
48 adamantinoma of long bones 9.9 CCND1 CDH1 PIK3CA
49 cholangiocarcinoma 9.9 CCND1 CDH1 PIK3CA
50 ovary epithelial cancer 9.9 CDH1 PIK3CA

Graphical network of the top 20 diseases related to Squamous Cell Carcinoma of the Oral Tongue:



Diseases related to Squamous Cell Carcinoma of the Oral Tongue

Symptoms & Phenotypes for Squamous Cell Carcinoma of the Oral Tongue

MGI Mouse Phenotypes related to Squamous Cell Carcinoma of the Oral Tongue:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.56 CCND1 CDH1 DCUN1D1 FABP5 KIF2A KRT16
2 integument MP:0010771 9.1 CCND1 CDH1 FABP5 KRT16 LAMC2 PIK3CA

Drugs & Therapeutics for Squamous Cell Carcinoma of the Oral Tongue

Search Clinical Trials , NIH Clinical Center for Squamous Cell Carcinoma of the Oral Tongue

Genetic Tests for Squamous Cell Carcinoma of the Oral Tongue

Anatomical Context for Squamous Cell Carcinoma of the Oral Tongue

MalaCards organs/tissues related to Squamous Cell Carcinoma of the Oral Tongue:

41
Tongue, Lung, Bone, Colon, Lymph Node, Pancreas, Thyroid

Publications for Squamous Cell Carcinoma of the Oral Tongue

Articles related to Squamous Cell Carcinoma of the Oral Tongue:

(show top 50) (show all 84)
# Title Authors Year
1
Nox4 Overexpression as a Poor Prognostic Factor in Patients with Oral Tongue Squamous Cell Carcinoma Receiving Surgical Resection. ( 30513726 )
2018
2
Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma. ( 30537401 )
2018
3
Immunohistochemical analysis of lymphatic vessel density and mast cells in oral tongue squamous cell carcinoma. ( 30482715 )
2018
4
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue. ( 30357923 )
2018
5
Ethnicity based variation in expression of E-cadherin in patients with squamous cell carcinoma of the oral tongue. ( 30405799 )
2018
6
EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma. ( 30300334 )
2018
7
Pre-treatment Neutrophil-to-Lymphocyte Ratio as a predictor for occult cervical metastasis in early stage (T1-T2 cN0) squamous cell carcinoma of the oral tongue. ( 30217309 )
2018
8
Expression of urokinase-type plasminogen activator and its receptor in squamous cell carcinoma of the oral tongue. ( 30231175 )
2018
9
Challenging the Requirement to Treat the Contralateral Neck in Cases With >4 mm Tumor Thickness in Patients Receiving Postoperative Radiation Therapy for Squamous Cell Carcinoma of the Oral Tongue or Floor of Mouth. ( 30234502 )
2018
10
Fermented Lingonberry Juice Inhibits Oral Tongue Squamous Cell Carcinoma Invasion In Vitro Similarly to Curcumin. ( 30150430 )
2018
11
Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review. ( 30151976 )
2018
12
Reactive Oxygen Species-Responsive Nanoparticles Based on PEGlated Prodrug for Targeted Treatment of Oral Tongue Squamous Cell Carcinoma by Combining Photodynamic Therapy and Chemotherapy. ( 30106279 )
2018
13
Silencing of uPAR via RNA interference inhibits invasion and migration of oral tongue squamous cell carcinoma. ( 30128018 )
2018
14
FGF-2 and FGFR-1 might be independent prognostic factors in oral tongue squamous cell carcinoma. ( 30129658 )
2018
15
Three-dimensional reconstruction with serial whole-mount sections of oral tongue squamous cell carcinoma: A preliminary study. ( 28960470 )
2018
16
Feasibility of desorption electrospray ionization mass spectrometry for diagnosis of oral tongue squamous cell carcinoma. ( 29078250 )
2018
17
Semaphorin-7A contributes to growth, migration and invasion of oral tongue squamous cell carcinoma through TGF-β-mediated EMT signaling pathway. ( 29509252 )
2018
18
Preoperative ultrasonography for tumor thickness evaluation in guiding management in patients with early oral tongue squamous cell carcinoma. ( 30050234 )
2018
19
Anaplastic transition within the cancer microenvironment in early-stage oral tongue squamous cell carcinoma is associated with local recurrence. ( 30085337 )
2018
20
miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma. ( 28096697 )
2017
21
Improved outcomes with oral tongue squamous cell carcinoma in Finland. ( 28481417 )
2017
22
Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. ( 28559012 )
2017
23
The maximum standardized uptake value increment calculated by dual-time-point 18F-fluorodeoxyglucose positron emission tomography predicts survival in patients with oral tongue squamous cell carcinoma. ( 28626254 )
2017
24
Prognostic value of volumetric FDG PET/CT parameters in patients with oral tongue squamous cell carcinoma who were treated by superselective intra-arterial chemoradiotherapy. ( 29039110 )
2017
25
The influence of marital status on survival in patients with oral tongue squamous cell carcinoma. ( 29137247 )
2017
26
A 16-gene signature predicting prognosis of patients with oral tongue squamous cell carcinoma. ( 29158988 )
2017
27
Clinical significance of three-dimensional measurement of tumour thickness on magnetic resonance imaging in patients with oral tongue squamous cell carcinoma. ( 26108641 )
2016
28
Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis. ( 26175310 )
2016
29
Efficacy of Elective Neck Dissection in T1/T2N0M0 Oral Tongue Squamous Cell Carcinoma: A Population-Based Analysis. ( 27165672 )
2016
30
Molecular Portrait of Oral Tongue Squamous Cell Carcinoma Shown by Integrative Meta-Analysis of Expression Profiles with Validations. ( 27280700 )
2016
31
Decreased expression of Beclin‑1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma. ( 27356955 )
2016
32
Correlation between clinical and MRI assessment of depth of invasion in oral tongue squamous cell carcinoma. ( 27876067 )
2016
33
Akt Signal Transduction Pathways and Nuclear Factor-kappa B (NF-κB) Transcription as a Molecular Target of Oral Tongue Squamous Cell Carcinoma (SP-C1) Using Papua's Anthill Plant ( Myrmecodia pendans ). ( 29023018 )
2016
34
Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma. ( 24677273 )
2015
35
Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through β-catenin signaling. ( 25378227 )
2015
36
Serum Level of Interleukin-6 in Patients with Oral Tongue Squamous cell Carcinoma. ( 26082902 )
2015
37
Early Oral Tongue Squamous Cell Carcinoma: Sampling of Margins From Tumor Bed and Worse Local Control. ( 26225798 )
2015
38
Investigation of the presence of HPV related oropharyngeal and oral tongue squamous cell carcinoma in Mozambique. ( 26590333 )
2015
39
Immunohistochemical study of vascular endothelial growth factor-C/vascular endothelial growth factor receptor-3 expression in oral tongue squamous cell carcinoma: Correlation with the induction of lymphangiogenesis. ( 26622791 )
2015
40
T4 squamous cell carcinoma of the oral tongue without mandibular involvement: surgery or chemoradiotherapy? ( 24275355 )
2014
41
Silencing Kif2a induces apoptosis in squamous cell carcinoma of the oral tongue through inhibition of the PI3K/Akt signaling pathway. ( 24248467 )
2014
42
TNM staging compared with a new clinicopathological model in predicting oral tongue squamous cell carcinoma survival. ( 23996811 )
2014
43
Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma. ( 24488688 )
2014
44
Prevalence and expression of human papillomavirus in 53 patients with oral tongue squamous cell carcinoma. ( 24511049 )
2014
45
Patterns of cervical lymph node metastases in oral tongue squamous cell carcinoma: implications for elective and therapeutic neck dissection. ( 24548727 )
2014
46
Response to "Sentinel lymph node biopsy versus elective neck dissection in patients with cT1-2N0 oral tongue squamous cell carcinoma". ( 24581750 )
2014
47
Comments on "Sentinel lymph node biopsy versus elective neck dissection in patients with cT1-2 N0 oral tongue squamous cell carcinoma". ( 24582509 )
2014
48
Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases. ( 24583139 )
2014
49
Preoperative evaluation of oral tongue squamous cell carcinoma with intraoral ultrasound and magnetic resonance imaging-comparison with histopathological tumour thickness and accuracy in guiding patient management. ( 24598430 )
2014
50
Resection for oral tongue squamous cell carcinoma: a paradigm shift from conventional wide resection towards compartmental resection. ( 24685261 )
2014

Variations for Squamous Cell Carcinoma of the Oral Tongue

Cosmic variations for Squamous Cell Carcinoma of the Oral Tongue:

9 (show top 50) (show all 202)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957917 TSC2 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 9
2 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 9
3 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 9
4 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 9
5 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
6 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 9
7 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 9
8 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 9
9 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 9
10 COSM11089 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.584T>C p.I195T 17:7674947-7674947 9
11 COSM43903 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.470T>G p.V157G 17:7675142-7675142 9
12 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 9
13 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 9
14 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 17:7674944-7674944 9
15 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 9
16 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 9
17 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 9
18 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 17:7673748-7673748 9
19 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 17:7674972-7674972 9
20 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 9
21 COSM43947 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 9
22 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 17:7674941-7674941 9
23 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 9
24 COSM44785 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.702C>G p.Y234* 17:7674261-7674261 9
25 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 17:7674887-7674887 9
26 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 17:7674884-7674884 9
27 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 9
28 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 17:7674923-7674923 9
29 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 9
30 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 17:7673811-7673811 9
31 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 9
32 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 9
33 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 17:7673812-7673812 9
34 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 17:7673839-7673839 9
35 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 9
36 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 9
37 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 17:7674291-7674291 9
38 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 17:7673806-7673806 9
39 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 9
40 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 17:7673776-7673776 9
41 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 17:7675131-7675131 9
42 COSM11147 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.370T>C p.C124R 17:7675999-7675999 9
43 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 9
44 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 17:7675995-7675995 9
45 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 9
46 COSM10645 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 9
47 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 17:7675085-7675085 9
48 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 9
49 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 17:7675174-7675174 9
50 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 9

Expression for Squamous Cell Carcinoma of the Oral Tongue

Search GEO for disease gene expression data for Squamous Cell Carcinoma of the Oral Tongue.

Pathways for Squamous Cell Carcinoma of the Oral Tongue

Pathways related to Squamous Cell Carcinoma of the Oral Tongue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.28 CCND1 CDH1 LAMC2 PIK3CA
2 11.1 CDH1 PIK3CA
3 11.1 CCND1 LAMC2 PIK3CA
4 10.91 CCND1 PIK3CA
5 10.86 CDH1 PIK3CA
6 10.72 CDH1 PIK3CA
7 10.43 CDH1 PIK3CA
8 10.32 CCND1 CDH1 PIK3CA

GO Terms for Squamous Cell Carcinoma of the Oral Tongue

Biological processes related to Squamous Cell Carcinoma of the Oral Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of mitotic nuclear division GO:0007088 8.96 CCND1 MKI67
2 epidermis development GO:0008544 8.8 FABP5 KRT16 LAMC2

Sources for Squamous Cell Carcinoma of the Oral Tongue

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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32 HPO
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34 ICD10 via Orphanet
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45 MESH via Orphanet
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62 PubMed
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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