MCID: SQM002
MIFTS: 40

Squamous Cell Papilloma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Squamous Cell Papilloma

MalaCards integrated aliases for Squamous Cell Papilloma:

Name: Squamous Cell Papilloma 12 15
Papilloma 44 73
Papilloma, Squamous Cell 73
Epidermoid Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:139
MeSH 44 D010212
NCIt 50 C3712
SNOMED-CT 68 63451008
UMLS 73 C0205874

Summaries for Squamous Cell Papilloma

MalaCards based summary : Squamous Cell Papilloma, also known as papilloma, is related to papilloma of choroid plexus and squamous cell papilloma of skin. An important gene associated with Squamous Cell Papilloma is CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein), and among its related pathways/superpathways are DNA Damage and Senescence and Autophagy in Cancer. The drugs Cervarix and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include cervix, tongue and skin, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 A squamous cell papilloma is a generally benign papilloma that arises from the stratified squamous... more...

Related Diseases for Squamous Cell Papilloma

Diseases related to Squamous Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 papilloma of choroid plexus 12.5
2 squamous cell papilloma of skin 12.1
3 esophagus squamous cell papilloma 12.1
4 inverted papilloma 11.2
5 papilloma 10.6
6 brain stem astrocytic neoplasm 10.6 CDKN2A TP53
7 keratinizing squamous cell carcinoma 10.5 CDKN2A TP53
8 abdominal tuberculosis 10.5 F2 TBP
9 mucoepidermoid esophageal carcinoma 10.5 TP53 WWOX
10 cerebral falx meningioma 10.5 F2 F3
11 intestinal impaction 10.5 F2 F3
12 spitz nevus 10.5 CDKN2A TP53
13 fournier gangrene 10.5 F2 F3
14 cerebral sinovenous thrombosis 10.5 F2 F3
15 leech infestation 10.4 F2 F3
16 bladder carcinoma in situ 10.4 CDKN2A TP53
17 qualitative platelet defect 10.4 F2 F3
18 giant hemangioma 10.4 F2 F3
19 sagittal sinus thrombosis 10.3 F2 F3
20 von willebrand disease, type 1 10.3 F2 F3
21 esophageal basaloid squamous cell carcinoma 10.3 SFRP4 TP53 WWOX
22 anterior cranial fossa meningioma 10.2 F2 F3 TP53
23 lymph node cancer 10.2 TP53 WWOX
24 skin carcinoma in situ 10.2 CDKN2A HPGDS
25 endocardium disease 10.2 F2 F3 HSPD1
26 esophagitis 10.2
27 bartholin's gland benign neoplasm 10.2 CDKN2A TP53
28 blue toe syndrome 10.2 F2 F3
29 cholecystitis 10.1 CDKN2A F2 TP53
30 vulva squamous cell carcinoma 10.1 CDKN2A TP53
31 laryngitis 10.0
32 squamous cell carcinoma 9.9
33 dysphagia 9.9
34 mucositis 9.8
35 urethritis 9.8
36 peptic esophagitis 9.8
37 pharyngitis 9.8
38 adenoma 9.8
39 lichen planus 9.8
40 laryngeal papillomatosis 9.8
41 intracranial embolism 9.7 F2 F3
42 respiratory system cancer 9.6 CD274 CDKN2A CYP2E1 TP53
43 gastrointestinal system cancer 9.6 CDKN2A F2 TP53 WWOX
44 cell type cancer 9.5 CD274 CDKN2A TP53 WWOX

Graphical network of the top 20 diseases related to Squamous Cell Papilloma:



Diseases related to Squamous Cell Papilloma

Symptoms & Phenotypes for Squamous Cell Papilloma

MGI Mouse Phenotypes related to Squamous Cell Papilloma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 HPGDS HSPD1 NMU TBP TP53 BMP5
2 growth/size/body region MP:0005378 10.29 AURKA BMP2 BMP5 CDKN2A ELP1 F2
3 homeostasis/metabolism MP:0005376 10.28 WWOX BMP2 BMP5 CD274 CDKN2A CYP2E1
4 cellular MP:0005384 10.26 AURKA BMP2 CD274 CDKN2A CLDN11 ELP1
5 cardiovascular system MP:0005385 10.24 BMP2 BMP5 CDKN2A CYP2E1 ELP1 F2
6 mortality/aging MP:0010768 10.24 AURKA BMP2 BMP5 CD274 CDKN2A CYP2E1
7 embryo MP:0005380 10.19 AURKA BMP2 BMP5 CDKN2A ELP1 F2
8 immune system MP:0005387 10.18 BMP2 BMP5 CD274 CDKN2A ELP1 F2
9 hematopoietic system MP:0005397 10.16 F2 F3 SFRP4 TP53 WWOX AURKA
10 digestive/alimentary MP:0005381 10.05 BMP2 BMP5 CDKN2A ELP1 F2 SFRP4
11 nervous system MP:0003631 10 F2 F3 HPGDS HSPD1 BMP2 CDKN2A
12 neoplasm MP:0002006 9.87 AURKA CDKN2A CYP2E1 F3 HPGDS TP53
13 no phenotypic analysis MP:0003012 9.7 AURKA CD274 CDKN2A ELP1 TBP TP53
14 reproductive system MP:0005389 9.61 F2 HSPD1 SFRP4 TP53 WWOX BMP2
15 skeleton MP:0005390 9.32 CD274 CDKN2A ELP1 F2 SFRP4 TBP

Drugs & Therapeutics for Squamous Cell Papilloma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cervarix 18 49 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009

Drugs for Squamous Cell Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 3
2 Antiviral Agents Phase 3
3 Immunoglobulins Phase 3
4 Vaccines Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Active, not recruiting NCT01375868 Phase 3

Search NIH Clinical Center for Squamous Cell Papilloma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: papilloma

Genetic Tests for Squamous Cell Papilloma

Anatomical Context for Squamous Cell Papilloma

MalaCards organs/tissues related to Squamous Cell Papilloma:

41
Cervix, Tongue, Skin, Trachea, Lung

Publications for Squamous Cell Papilloma

Articles related to Squamous Cell Papilloma:

(show all 48)
# Title Authors Year
1
Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )
2018
2
Endoscopic mucosal resection of rectal squamous cell papilloma. ( 29351698 )
2018
3
Esophageal Squamous Cell Papilloma. ( 27751518 )
2017
4
Giant Ocular Surface Squamous Cell Papilloma Treated With Topical Mitomycin C. ( 28715561 )
2017
5
Partial glossectomy for treating extensive oral squamous cell papilloma. ( 27544018 )
2016
6
Assessment of the incidence of squamous cell papilloma of the esophagus and the presence of high-risk human papilloma virus. ( 27001250 )
2016
7
Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. ( 27696538 )
2016
8
Verrucous carcinoma and squamous cell papilloma of the oral cavity: Report of two cases and review of literature. ( 26430380 )
2015
9
Esophageal Squamous Cell Papilloma: A Not-So-Rare Cause of Dysphagia. ( 27134598 )
2015
10
Recalcitrant oral squamous cell papilloma lesions in two HIV-infected patients successfully treated with topical imiquimod. ( 25932059 )
2015
11
Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report. ( 26137004 )
2015
12
Urethral squamous cell papilloma: Case report and literature review. ( 24940467 )
2014
13
Oral focal fibrous hyperplasia and squamous cell papilloma treated with an erbium laser. Case presentation. ( 24654496 )
2014
14
Oral pathology quiz #85. Case number 2. Squamous cell papilloma. ( 25739139 )
2014
15
Squamous cell papilloma of the urinary bladder endoscopically mimicking cancer. ( 24159399 )
2013
16
Solitary bronchial squamous cell papilloma - another human papillomavirus (HPV)-associated benign tumor: systematic review and meta-analysis. ( 24596531 )
2013
17
Squamous cell papilloma of the conjunctiva due to human papillomavirus (HPV): presentation of two cases and review of literature. ( 23055678 )
2012
18
Pharyngeal squamous cell papilloma in adult Japanese: comparison with laryngeal papilloma in clinical manifestations and HPV infection. ( 22215212 )
2012
19
Oral pathology quiz #43. Case number 4. Squamous cell papilloma. ( 16795958 )
2004
20
Oral pathology quiz # 42. Case 2. Squamous cell papilloma. ( 15160431 )
2004
21
Solitary squamous cell papilloma of the lung in a 40-year-old woman with recurrent laryngeal papillomatosis. ( 10849335 )
2000
22
Alcohol, smoking and papillomavirus infection as risk factors for esophageal squamous-cell papilloma and esophageal squamous-cell carcinoma in Italy. ( 10842204 )
2000
23
Squamous cell papilloma of the esophagus. ( 8855780 )
1996
24
Squamous cell papilloma of the esophagus: a clinicopathologic and follow-up study of 25 cases. ( 8304311 )
1994
25
Detection of human papilloma virus type 6 DNA in an esophageal squamous cell papilloma. ( 8013499 )
1994
26
Prognostic importance of human papilloma virus typing in squamous cell papilloma of the bronchus: comparison of in situ hybridization and the polymerase chain reaction. ( 7959664 )
1994
27
Solitary squamous cell papilloma of the trachea. ( 8417677 )
1993
28
Esophageal squamous cell papilloma, suspected of squamous cell carcinoma. ( 8012070 )
1993
29
Cytological appearances of a solitary squamous cell papilloma with associated mucous gland adenoma in the lung. ( 1421008 )
1992
30
A squamous cell papilloma as a cause of dysphagia and vomiting. ( 2369543 )
1990
31
Detection of human papillomavirus type 11 DNA in a conjunctival squamous cell papilloma by in situ hybridization with biotinylated probes. ( 2801046 )
1989
32
Squamous cell papilloma at the tracheoesophageal puncture stoma. ( 3355697 )
1988
33
Squamous cell papilloma of the esophagus. Report on 35 endoscopic cases. ( 3342776 )
1988
34
Pigmented squamous cell papilloma--a case report. ( 3507413 )
1987
35
Squamous cell papilloma of the esophagus: report of four cases. ( 3996864 )
1985
36
Squamous cell papilloma of the esophagus in a child. ( 4055285 )
1985
37
Endoscopic removal of squamous cell papilloma of esophagus: a case report and review of literature. ( 6400387 )
1984
38
Evidence suggesting human papillomavirus (HPV) etiology for the squamous cell papilloma of the paranasal sinus. ( 6305303 )
1983
39
Squamous cell papilloma of the esophagus: a tumour probably caused by human papilloma virus (HPV). ( 6188592 )
1982
40
Squamous cell papilloma of the esophagus: a case report and review of the literature. ( 7451069 )
1980
41
Squamous cell papilloma of esophagus. ( 737594 )
1978
42
Squamous cell papilloma of the esophagus. Report of a case after peptic esophagitis and repeated bougienage with review of the literature. ( 640347 )
1978
43
Oral epithelial atypia in denture induced hyperplasia, lichen planus and squamous cell papilloma. ( 804458 )
1975
44
Solitary squamous cell papilloma of bronchial origin. ( 4899741 )
1969
45
Squamous cell papilloma of the external auditory canal and middle ear treated with radiation therapy. ( 5701321 )
1968
46
The vascular bed in squamous-cell papilloma of the cervix and its significance for the colposcopical diagnosis of these lesions. ( 5707024 )
1968
47
Squamous-cell papilloma of the uterine cervix; report of a case. ( 13502811 )
1957
48
Squamous cell papilloma of the cervix uteri. ( 13005077 )
1952

Variations for Squamous Cell Papilloma

Cosmic variations for Squamous Cell Papilloma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM13702 CDKN2A upper aerodigestive tract,larynx,other,papilloma c.293A>G p.H98R 9:21971066-21971066 7

Expression for Squamous Cell Papilloma

Search GEO for disease gene expression data for Squamous Cell Papilloma.

Pathways for Squamous Cell Papilloma

GO Terms for Squamous Cell Papilloma

Cellular components related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 BMP2 CD274 F3 HSPD1 SFRP4
2 pronucleus GO:0045120 8.62 AURKA TBP

Biological processes related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 BMP2 BMP5 CDKN2A SFRP4 TP53
2 positive regulation of cell migration GO:0030335 9.73 BMP2 CD274 ELP1 F3
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.65 CDKN2A F3 HSPD1
4 positive regulation of apoptotic process GO:0043065 9.55 BMP2 CDKN2A HSPD1 SFRP4 TP53
5 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 AURKA CNOT2 TP53
6 replicative senescence GO:0090399 9.49 CDKN2A TP53
7 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.46 BMP2 BMP5
8 circadian behavior GO:0048512 9.4 NMU TP53
9 negative regulation of steroid biosynthetic process GO:0010894 9.26 BMP2 BMP5
10 negative regulation of aldosterone biosynthetic process GO:0032348 8.96 BMP2 BMP5
11 negative regulation of cortisol biosynthetic process GO:2000065 8.62 BMP2 BMP5

Molecular functions related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 AURKA BMP2 CD274 CDKN2A CLDN11 CNOT2
2 BMP receptor binding GO:0070700 9.16 BMP2 BMP5
3 enzyme binding GO:0019899 9.02 CYP2E1 HSPD1 TBP TP53 WWOX

Sources for Squamous Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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