MCID: SQM002
MIFTS: 46

Squamous Cell Papilloma

Categories: Cancer diseases, Oral diseases, Skin diseases

Aliases & Classifications for Squamous Cell Papilloma

MalaCards integrated aliases for Squamous Cell Papilloma:

Name: Squamous Cell Papilloma 12 15
Papilloma 44 73
Papilloma, Squamous Cell 73
Epidermoid Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:139
MeSH 44 D010212
NCIt 50 C3712
SNOMED-CT 68 63451008

Summaries for Squamous Cell Papilloma

MalaCards based summary : Squamous Cell Papilloma, also known as papilloma, is related to laryngeal squamous cell carcinoma and bladder squamous cell carcinoma. An important gene associated with Squamous Cell Papilloma is CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein), and among its related pathways/superpathways are DNA Damage and Senescence and Autophagy in Cancer. The drugs Cervarix and Gardasil have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and tongue, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 A squamous cell papilloma is a generally benign papilloma that arises from the stratified squamous... more...

Related Diseases for Squamous Cell Papilloma

Diseases related to Squamous Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 374)
# Related Disease Score Top Affiliating Genes
1 laryngeal squamous cell carcinoma 30.2 AURKA CDKN2A TP53
2 bladder squamous cell carcinoma 29.7 CDKN2A TP53
3 papilloma of choroid plexus 12.6
4 intraductal papilloma 12.4
5 squamous cell papilloma of skin 12.3
6 esophagus squamous cell papilloma 12.2
7 central breast papilloma 12.2
8 bladder transitional cell papilloma 12.2
9 skin papilloma 12.2
10 sclerosing breast papilloma 12.2
11 atypical breast papilloma 12.2
12 atypical choroid plexus papilloma 12.1
13 transitional papilloma 12.1
14 breast duct papilloma 12.1
15 ureter inverted papilloma 12.1
16 frontal sinus inverted papilloma 12.1
17 maxillary sinus inverted papilloma 12.1
18 ethmoid sinus inverted papilloma 12.1
19 sphenoid sinus inverted papilloma 12.1
20 cervix squamous papilloma 12.1
21 fallopian tube serous papilloma 12.0
22 urinary bladder inverted papilloma 12.0
23 serous surface papilloma 12.0
24 inverted transitional papilloma 12.0
25 nasal vestibule papilloma 12.0
26 vaginal mullerian papilloma 11.9
27 vaginal squamous papilloma 11.9
28 frontal sinus schneiderian papilloma 11.9
29 renal pelvis inverted papilloma 11.9
30 ethmoid sinus schneiderian papilloma 11.9
31 urethra inverted papilloma 11.9
32 ureter urothelial papilloma 11.9
33 sphenoid sinus schneiderian papilloma 11.9
34 maxillary sinus schneiderian papilloma 11.9
35 cervical mullerian papilloma 11.9
36 bladder squamous papilloma 11.9
37 vulvar squamous papilloma 11.9
38 urethral urothelial papilloma 11.9
39 verrucous papilloma 11.9
40 nasal cavity inverting papilloma 11.9
41 renal pelvis urothelial papilloma 11.9
42 ovarian surface papilloma 11.9
43 microscopic breast papilloma 11.9
44 larynx squamous papilloma 11.8
45 recurrent respiratory papillomatosis 11.8
46 focal dermal hypoplasia 11.6
47 urinary tract papillary transitional cell benign neoplasm 11.4
48 inverted papilloma 11.4
49 papillary adenoma 11.4
50 focal epithelial hyperplasia 11.3

Graphical network of the top 20 diseases related to Squamous Cell Papilloma:



Diseases related to Squamous Cell Papilloma

Symptoms & Phenotypes for Squamous Cell Papilloma

MGI Mouse Phenotypes related to Squamous Cell Papilloma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 BMP5 CD274 CDKN2A CLDN11 CYP2E1 ELP1
2 growth/size/body region MP:0005378 10.29 AURKA BMP2 BMP5 CDKN2A ELP1 F2
3 homeostasis/metabolism MP:0005376 10.28 BMP2 BMP5 CD274 CDKN2A CYP2E1 ELP1
4 cellular MP:0005384 10.26 AURKA BMP2 CD274 CDKN2A CLDN11 ELP1
5 cardiovascular system MP:0005385 10.24 BMP2 BMP5 CDKN2A CYP2E1 ELP1 F2
6 mortality/aging MP:0010768 10.24 AURKA BMP2 BMP5 CD274 CDKN2A CYP2E1
7 embryo MP:0005380 10.19 AURKA BMP2 BMP5 CDKN2A ELP1 F2
8 immune system MP:0005387 10.18 BMP2 BMP5 CD274 CDKN2A ELP1 F2
9 hematopoietic system MP:0005397 10.16 AURKA BMP2 CD274 CDKN2A ELP1 F2
10 digestive/alimentary MP:0005381 10.05 BMP2 BMP5 CDKN2A ELP1 F2 SFRP4
11 nervous system MP:0003631 10 BMP2 CDKN2A CLDN11 ELP1 F2 F3
12 neoplasm MP:0002006 9.87 AURKA CDKN2A CYP2E1 F3 HPGDS TP53
13 no phenotypic analysis MP:0003012 9.7 AURKA CD274 CDKN2A ELP1 TBP TP53
14 reproductive system MP:0005389 9.61 BMP2 BMP5 CDKN2A CLDN11 F2 HSPD1
15 skeleton MP:0005390 9.32 BMP2 BMP5 CD274 CDKN2A ELP1 F2

Drugs & Therapeutics for Squamous Cell Papilloma

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Cervarix 18 49 Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant GlaxoSmithKline October 2009
2
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006
3
Tafinlar 18 49 DABRAFENIB MESYLATE GlaxoSmithKline May 2013
4
Zelboraf 18 49 VEMURAFENIB Roche August of 2011

Drugs for Squamous Cell Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antiviral Agents Phase 3
2 Vaccines Phase 3
3 Immunologic Factors Phase 3
4 Antibodies Phase 3
5 Immunoglobulins Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Completed NCT01375868 Phase 3

Search NIH Clinical Center for Squamous Cell Papilloma

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: papilloma

Genetic Tests for Squamous Cell Papilloma

Anatomical Context for Squamous Cell Papilloma

MalaCards organs/tissues related to Squamous Cell Papilloma:

41
Cervix, Skin, Tongue, Testes, Lung, Lymph Node, T Cells

Publications for Squamous Cell Papilloma

Articles related to Squamous Cell Papilloma:

(show top 50) (show all 553)
# Title Authors Year
1
A 17-year-old woman with a solitary, mixed squamous cell and glandular papilloma of the bronchus. ( 30519472 )
2019
2
Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review. ( 30546813 )
2019
3
Laryngeal squamous cell papilloma is highly associated with human papillomavirus. ( 29447361 )
2018
4
Endoscopic mucosal resection of rectal squamous cell papilloma. ( 29351698 )
2018
5
Low Prevalence of Human Papilloma Virus in Patients with Breast Cancer, Kerman; Iran ( 30485938 )
2018
6
Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes. ( 30425937 )
2018
7
A report of human papilloma virus-16 associated vaginal carcinoma after thirty-two years of successful radiation therapy for cervical cancer. ( 30539058 )
2018
8
Awareness and Knowledge of Human Papilloma Virus and Cervical Cancer in Women with High Pap Uptake. ( 30415376 )
2018
9
Human papilloma virus E1-specific T cell immune response is associated with the prognosis of cervical cancer patients with squamous cell carcinoma. ( 30479656 )
2018
10
New prophylactics human papilloma virus (HPV) vaccines against cervical cancer. ( 30370796 )
2018
11
Implementation of Multicolor Melt Curve Analysis for High-Risk Human Papilloma Virus Detection in Low- and Middle-Income Countries: A Pilot Study for Expanded Cervical Cancer Screening in Honduras. ( 30241169 )
2018
12
Glutathione S-transferase omega gene polymorphism as a biomarker for human papilloma virus and cervical cancer in Iranian women ( 30115608 )
2018
13
Reducing incidence of cervical cancer: knowledge and attitudes of caregivers in Nigerian city to human papilloma virus vaccination. ( 30140306 )
2018
14
Facilitators and Barriers of Cervical Cancer Screening and Human Papilloma Virus Vaccination Among Somali Refugee Women in the United States: A Qualitative Analysis. ( 30170512 )
2018
15
Human papilloma virus genotyping for the cross-sectional and longitudinal probability of developing cervical intraepithelial neoplasia grade 2 or more. ( 29453769 )
2018
16
Primary Choroid Plexus Papilloma over Sellar Region Mimicking with Craniopharyngioma: A Case Report and Literature Review. ( 30140600 )
2018
17
HPV papilloma in the lung in a Crohn's disease patient treated with Infliximab. ( 30350537 )
2018
18
Choroid Plexus Papilloma and Factor XIII Deficiency: Case Report. ( 30176663 )
2018
19
Esophageal Squamous Papilloma in a Pediatric Patient With Helicobacter pylori Gastritis. ( 28382843 )
2018
20
Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study. ( 28975630 )
2018
21
Human Papilloma Virus and the Risk of Squamous Cell Carcinoma Arising in Hidradenitis Suppurativa. ( 29169556 )
2018
22
Rare case of male breast intraductal papilloma progressing to invasive ductal carcinoma: A radiologic-pathologic correlation. ( 30073044 )
2018
23
Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast. ( 30455948 )
2018
24
Intraductal Papilloma Without Atypia on Image- Guided Breast Biopsy: Upgrade Rates to Carcinoma at Surgical Excision. ( 30498423 )
2018
25
Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis. ( 29649889 )
2018
26
MR imaging and CT features of oncocytic papilloma of the sinonasal tract with comparison to inverted papilloma. ( 29987980 )
2018
27
Sinonasal inverted papilloma recurrence rates and evaluation of current staging systems. ( 30033450 )
2018
28
An inverted papilloma arising from the middle turbinate and extending to the maxillary sinus ostium. ( 30036423 )
2018
29
Intranasal endoscopic prelacrimal recess approach for maxillary sinus inverted papilloma. ( 30078130 )
2018
30
Resection of Inverted Papilloma of the Maxillary Sinus via a Prelacrimal Recess Approach: A Multicenter Retrospective Analysis of Surgical Efficacy. ( 30251558 )
2018
31
Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma. ( 30376194 )
2018
32
Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma. ( 30411788 )
2018
33
A rare presentation of a paediatric sinonasal inverted papilloma. ( 30515294 )
2018
34
Imaging predictors for malignant transformation of inverted papilloma. ( 30515841 )
2018
35
Sinonasal inverted papilloma associated with small cell neuroendocrine carcinoma: A case report and literature review of rare malignancies associated with inverted papilloma. ( 30545727 )
2018
36
Origin site-based staging system of sinonasal inverted papilloma for application to endoscopic sinus surgery. ( 30554455 )
2018
37
Lack of Uptake of Prophylactic Human Papilloma Virus Vaccine Among Women With Systemic Lupus Erythematosus Seen at a Regional Medical Center. ( 30028808 )
2018
38
The effect of history of abnormal pap smear or preceding HPV infection on the humoral immune response to Quadrivalent Human Papilloma virus (qHPV) vaccine in women with systemic lupus erythematosus. ( 29708835 )
2018
39
Factors of the epidemiological triad that influence the persistence of human papilloma virus infection in women with systemic lupus erythematosus. ( 29732937 )
2018
40
Bacterial biofilm and chronic sialadenitis, survival outcomes in human papilloma virus positive oral cancer, and long-term use of trimethoprim/sulfamethoxazole in recalcitrant chronic rhinosinusitis. ( 30058521 )
2018
41
Human papilloma virus: An etiological and prognostic factor for oral cancer? ( 29322686 )
2018
42
Human Papilloma Virus associated with oral cancer and preventive strategies: the role of vaccines. ( 29460519 )
2018
43
Analysis of the application values of different combination schemes of liquid-based cytology and high-risk human papilloma virus test in the screening of high-grade cervical lesions. ( 30484489 )
2018
44
Prevalence of Human Papilloma Virus Types in Turkish and Albanian Women. ( 30498300 )
2018
45
Awareness of primary health care physicians about human papilloma virus infection and its vaccination: a cross-sectional survey from multiple clinics in Saudi Arabia. ( 30532560 )
2018
46
A papilloma in a large cyst of the breast: A case report. ( 30557652 )
2018
47
Investigation of the presence of HPV on KTP laser fibers following KTP laser treatment of papilloma. ( 29171656 )
2018
48
Current Status and Future Directions of Treatment Deintensification in Human Papilloma Virus-associated Oropharyngeal Squamous Cell Carcinoma. ( 29173753 )
2018
49
Management of benign papilloma without atypia diagnosed at ultrasound-guided core needle biopsy: Scoring system for predicting malignancy. ( 29174198 )
2018
50
Cost effectiveness of human papilloma virus vaccination in low and middle income countries: a systematic review of literature. ( 29183182 )
2018

Variations for Squamous Cell Papilloma

Cosmic variations for Squamous Cell Papilloma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM13702 CDKN2A upper aerodigestive tract,larynx,other,papilloma c.293A>G p.H98R 9:21971066-21971066 7

Expression for Squamous Cell Papilloma

Search GEO for disease gene expression data for Squamous Cell Papilloma.

Pathways for Squamous Cell Papilloma

GO Terms for Squamous Cell Papilloma

Cellular components related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 BMP2 CD274 F3 HSPD1 SFRP4
2 pronucleus GO:0045120 8.62 AURKA TBP

Biological processes related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 BMP2 BMP5 CDKN2A SFRP4 TP53
2 positive regulation of cell migration GO:0030335 9.73 BMP2 CD274 ELP1 F3
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.65 CDKN2A F3 HSPD1
4 regulation of signal transduction by p53 class mediator GO:1901796 9.63 AURKA TBP TP53
5 positive regulation of apoptotic process GO:0043065 9.55 BMP2 CDKN2A HSPD1 SFRP4 TP53
6 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 AURKA CNOT2 TP53
7 replicative senescence GO:0090399 9.49 CDKN2A TP53
8 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.4 BMP2 BMP5
9 negative regulation of steroid biosynthetic process GO:0010894 9.26 BMP2 BMP5
10 negative regulation of aldosterone biosynthetic process GO:0032348 8.96 BMP2 BMP5
11 negative regulation of cortisol biosynthetic process GO:2000065 8.62 BMP2 BMP5

Molecular functions related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 AURKA BMP2 CD274 CDKN2A CLDN11 CNOT2
2 protease binding GO:0002020 9.43 F3 HSPD1 TP53
3 enzyme binding GO:0019899 9.35 CYP2E1 HSPD1 TBP TP53 WWOX
4 BMP receptor binding GO:0070700 9.16 BMP2 BMP5

Sources for Squamous Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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