MCID: SQM002
MIFTS: 48

Squamous Cell Papilloma

Categories: Cancer diseases, Oral diseases, Skin diseases

Aliases & Classifications for Squamous Cell Papilloma

MalaCards integrated aliases for Squamous Cell Papilloma:

Name: Squamous Cell Papilloma 12 15
Papilloma 45 74
Papilloma, Squamous Cell 74
Epidermoid Papilloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:139
MeSH 45 D010212
NCIt 51 C3712
SNOMED-CT 69 63451008

Summaries for Squamous Cell Papilloma

MalaCards based summary : Squamous Cell Papilloma, also known as papilloma, is related to anogenital venereal wart and laryngeal squamous cell carcinoma. An important gene associated with Squamous Cell Papilloma is CNTROB (Centrobin, Centriole Duplication And Spindle Assembly Protein), and among its related pathways/superpathways are Regulation of TP53 Activity and Senescence and Autophagy in Cancer. The drugs Immunoglobulins and Antiviral Agents have been mentioned in the context of this disorder. Affiliated tissues include cervix, skin and testes, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 A squamous cell papilloma is a generally benign papilloma that arises from the stratified squamous... more...

Related Diseases for Squamous Cell Papilloma

Diseases related to Squamous Cell Papilloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 anogenital venereal wart 32.1 CDKN2A TP53
2 laryngeal squamous cell carcinoma 30.1 AURKA CDKN2A TP53
3 anal squamous cell carcinoma 30.0 CDKN2A TP53
4 oral leukoplakia 30.0 CDKN2A TP53
5 bladder squamous cell carcinoma 29.8 CDKN2A TP53
6 vulva squamous cell carcinoma 29.7 CDKN2A TP53
7 cholecystitis 29.6 CDKN2A GPT TP53
8 papilloma of choroid plexus 12.7
9 intraductal papilloma 12.4
10 squamous cell papilloma of skin 12.3
11 esophagus squamous cell papilloma 12.2
12 central breast papilloma 12.2
13 bladder transitional cell papilloma 12.2
14 skin papilloma 12.2
15 transitional papilloma 12.2
16 sclerosing breast papilloma 12.2
17 atypical breast papilloma 12.2
18 atypical choroid plexus papilloma 12.2
19 breast duct papilloma 12.2
20 ureter inverted papilloma 12.1
21 frontal sinus inverted papilloma 12.1
22 nasal vestibule papilloma 12.1
23 maxillary sinus inverted papilloma 12.1
24 ethmoid sinus inverted papilloma 12.1
25 sphenoid sinus inverted papilloma 12.1
26 cervix squamous papilloma 12.1
27 fallopian tube serous papilloma 12.1
28 urinary bladder inverted papilloma 12.1
29 vulvar squamous papilloma 12.1
30 serous surface papilloma 12.1
31 inverted transitional papilloma 12.0
32 vaginal mullerian papilloma 12.0
33 vaginal squamous papilloma 12.0
34 frontal sinus schneiderian papilloma 12.0
35 renal pelvis inverted papilloma 12.0
36 ethmoid sinus schneiderian papilloma 12.0
37 urethra inverted papilloma 12.0
38 ureter urothelial papilloma 12.0
39 sphenoid sinus schneiderian papilloma 12.0
40 maxillary sinus schneiderian papilloma 12.0
41 cervical mullerian papilloma 12.0
42 bladder squamous papilloma 11.9
43 urethral urothelial papilloma 11.9
44 verrucous papilloma 11.9
45 nasal cavity inverting papilloma 11.9
46 renal pelvis urothelial papilloma 11.9
47 ovarian surface papilloma 11.9
48 microscopic breast papilloma 11.9
49 larynx squamous papilloma 11.9
50 recurrent respiratory papillomatosis 11.8

Graphical network of the top 20 diseases related to Squamous Cell Papilloma:



Diseases related to Squamous Cell Papilloma

Symptoms & Phenotypes for Squamous Cell Papilloma

MGI Mouse Phenotypes related to Squamous Cell Papilloma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 BMP5 CDKN2A CLDN11 CYP2E1 ELP1 HPGDS
2 cardiovascular system MP:0005385 9.97 BMP2 BMP5 CDKN2A CYP2E1 ELP1 KIDINS220
3 embryo MP:0005380 9.86 AURKA BMP2 BMP5 CDKN2A ELP1 HSPD1
4 growth/size/body region MP:0005378 9.85 AURKA BMP2 BMP5 CDKN2A ELP1 HSPD1
5 mortality/aging MP:0010768 9.73 AURKA BMP2 BMP5 CDKN2A CYP2E1 ELP1
6 skeleton MP:0005390 9.23 BMP2 BMP5 CDKN2A ELP1 GPT SFRP4

Drugs & Therapeutics for Squamous Cell Papilloma

Drugs for Squamous Cell Papilloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins Phase 3
2 Antiviral Agents Phase 3
3 Vaccines Phase 3
4 Antibodies Phase 3
5 Immunologic Factors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Vaccination in Patients With Recurrent Respiratory Papillomatosis Completed NCT01375868 Phase 3

Search NIH Clinical Center for Squamous Cell Papilloma

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: papilloma

Genetic Tests for Squamous Cell Papilloma

Anatomical Context for Squamous Cell Papilloma

MalaCards organs/tissues related to Squamous Cell Papilloma:

42
Cervix, Skin, Testes, Tongue, T Cells, Bone, Lymph Node

Publications for Squamous Cell Papilloma

Articles related to Squamous Cell Papilloma:

(show top 50) (show all 1491)
# Title Authors Year
1
Is human papillomavirus associated with breast cancer or papilloma presenting with pathologic nipple discharge? ( 30785026 )
2019
2
Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins. ( 30642295 )
2019
3
Prospective cohort study examining cervical cancer screening methods in HIV-positive and HIV-negative Cambodian Women: a comparison of human papilloma virus testing, visualization with acetic acid and digital colposcopy. ( 30804036 )
2019
4
Health professionals' willingness to pay and associated factors for human papilloma virus vaccination to prevent cervical cancer at College of Medicine and Health Sciences University of Gondar, Northwest Ethiopia. ( 30678735 )
2019
5
New prophylactics human papilloma virus (HPV) vaccines against cervical cancer. ( 30370796 )
2019
6
Association of Base Excision Repair Gene hOGG1 Ser326Cys Polymorphism with Susceptibility to Cervical Squamous Cell Carcinoma and High-Risk Human Papilloma Virus Infection in a Chinese Population. ( 30648893 )
2019
7
Apparent diffusion coefficients are closely related with high-risk human papilloma virus infection in cervical squamous cell carcinoma patients. ( 30722670 )
2019
8
The management of numerous carcinomatous sequelae of human papilloma virus in an allogeneic stem cell transplant patient with chronic graft versus host disease. ( 30733986 )
2019
9
Intraductal papilloma of the male breast: a case report and review of the literature. ( 30788101 )
2019
10
Intraductal papilloma of the breast - management. ( 30860277 )
2019
11
Origin site-based staging system of sinonasal inverted papilloma for application to endoscopic sinus surgery. ( 30554455 )
2019
12
Outcomes of sinonasal inverted papilloma resection by surgical approach: an updated systematic review and meta-analysis. ( 30748098 )
2019
13
Cervical nodal metastasis after malignant conversion of sinonasal inverted papilloma: Report of a rare case and literature review. ( 30846175 )
2019
14
Surgical outcomes of sinonasal inverted papilloma: a 17 year review. ( 30852156 )
2019
15
EGFR and KRAS mutations in Chinese patients with sinonasal inverted papilloma and oncocytic papilloma. ( 30916792 )
2019
16
Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma. ( 30411788 )
2019
17
Gallbladder Papilloma in a Child Unmasking Metachromatic Leukodystrophy: A Case Report With Review of Literature. ( 30912695 )
2019
18
Prevalence of high-risk human papilloma virus in liquid-based cervical samples from Turkish women with normal and abnormal cytology. ( 30457213 )
2019
19
A 17-year-old woman with a solitary, mixed squamous cell and glandular papilloma of the bronchus. ( 30519472 )
2019
20
Posterior fossa choroid plexus papilloma with focal ependymal differentiation in an adult patient: A case report and literature review. ( 30546813 )
2019
21
An ultrasensitive label free human papilloma virus DNA biosensor using gold nanotubes based on nanoporous polycarbonate in electrical alignment. ( 30598155 )
2019
22
Isolated Schneiderian papilloma of the middle ear cleft. ( 30610035 )
2019
23
Vanishing diffuse leptomeningeal contrast enhancement in an infant with choroid plexus papilloma. ( 30617713 )
2019
24
Human papilloma virus identification in ocular surface squamous neoplasia by p16 immunohistochemistry and DNA chip test: A strobe-compliant article. ( 30633172 )
2019
25
Exploring the Papillomaviral Proteome to Identify Potential Candidates for a Chimeric Vaccine against Cervix Papilloma Using Immunomics and Computational Structural Vaccinology. ( 30650527 )
2019
26
Mixed squamous cell and glandular papilloma of the lung: A case report of a novel mutation in the BRAF gene and coexistent HPV infection, possible relationship to ciliated muconodular papillary tumor. ( 30664316 )
2019
27
Validation of the HPV Impact Profile (HIP) in Portuguese Women with Human Papilloma Virus. ( 30686056 )
2019
28
Safety concerns with human papilloma virus immunization in Japan: Analysis and evaluation of Nagoya City's surveillance data for adverse events. ( 30693675 )
2019
29
Expression of p16 and p27 protein in cervical exfoliated cells and its relationship with high risk human papilloma virus in cervical lesions. ( 30693740 )
2019
30
Prophylactic human papilloma virus vaccination in head and neck: indications and future perspectives. ( 30694913 )
2019
31
Excision recommended in high-risk patients: Revisiting the diagnosis of papilloma on core biopsy in the context of patient risk. ( 30697873 )
2019
32
Prevalence of high-risk human papilloma virus in women with high-grade squamous cell intraepithelial lesions in Botswana using Abbott RealTime HPV assay. ( 30699172 )
2019
33
Stereophotogrammetric 3D photography is an accurate and precise planimetric method for the clinical visualization and quantification of HPV-induced skin lesions. ( 30720900 )
2019
34
Molecular Genetic Study to Detect Prevalence of High-risk Human Papilloma Virus Strains (type 16 and 18) in Cervical Lesions and Asymptomatic Healthy Subjects of Rural Central India. ( 30745737 )
2019
35
Molecular Diagnosis of Human Papilloma Virus by PCR. ( 30755567 )
2019
36
High-risk human papilloma virus testing improves diagnostic performance to predict moderate-to-high grade anal intraepithelial neoplasia in HIV-infected men who have sex with men in low-to-absent cytological abnormalities. ( 30770528 )
2019
37
Impact of human papilloma virus in patients with oral and oropharyngeal squamous cell carcinomas. ( 30777194 )
2019
38
Two-Year Results of Community-Based Screening Program for Human Papilloma Virus DNA in Çorum Province. ( 30793760 )
2019
39
Prevalence of epithelial abnormalities and high-risk human papilloma virus in cervicovaginal Pap smears of population subgroups as a guide toward evidence-based best practice. ( 30801970 )
2019
40
Human Papilloma Virus Infection. ( 30817264 )
2019
41
Knowledge, Attitudes and Practices Regarding Human Papilloma Virus Communication and Vaccine Advocacy Among Minnesota Dentists and Dental Hygienists. ( 30819844 )
2019
42
Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder. ( 30838648 )
2019
43
Clinical Activity of Nivolumab for Human Papilloma Virus-Related Juvenile-Onset Recurrent Respiratory Papillomatosis. ( 30842242 )
2019
44
Sexual dysfunction in women with human papilloma virus infection in the Turkish population. ( 30856026 )
2019
45
Immune Modulation in HLA-G Expressing Head and Neck Squamous Cell Carcinoma in Relation to Human Papilloma Virus Positivity: A Study From Northeast India. ( 30859089 )
2019
46
Influence of human Papilloma Virus (hPV) infection on early pregnancy. ( 30860272 )
2019
47
Prevalence of human papilloma virus in oropharyngeal, tongue and lip squamous cell carcinoma: an experience from the Egyptian National Cancer Institute. ( 30867228 )
2019
48
Retraction: Interferon-β Induces Cellular Senescence in Cutaneous Human Papilloma Virus-Transformed Human Keratinocytes by Affecting p53 Transactivating Activity. ( 30875405 )
2019
49
Role of B7-H4 in the Progression and Prognosis of Cervical Inflammation to Cancer After Human Papilloma Virus Infection. ( 30890234 )
2019
50
Successful treatment of oral human papilloma by local injection 5-aminolevulinic acid-mediated photodynamic therapy: a case report. ( 30890459 )
2019

Variations for Squamous Cell Papilloma

Cosmic variations for Squamous Cell Papilloma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM13702 CDKN2A upper aerodigestive tract,larynx,other,papilloma c.293A>G p.H98R 9:21971066-21971066 0

Expression for Squamous Cell Papilloma

Search GEO for disease gene expression data for Squamous Cell Papilloma.

Pathways for Squamous Cell Papilloma

GO Terms for Squamous Cell Papilloma

Cellular components related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.93 AURKA CDKN2A CNOT2 CNTROB CYP2E1 ELP1
2 cytosol GO:0005829 9.7 AURKA CDKN2A CNOT2 CNTROB ELP1 GPT
3 pronucleus GO:0045120 8.62 AURKA TBP

Biological processes related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 BMP2 BMP5 CDKN2A SFRP4 TP53
2 regulation of signal transduction by p53 class mediator GO:1901796 9.61 AURKA TBP TP53
3 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.5 AURKA CNOT2 TP53
4 RNA polymerase II preinitiation complex assembly GO:0051123 9.49 TBP TP53
5 apoptotic mitochondrial changes GO:0008637 9.48 CDKN2A HSPD1
6 replicative senescence GO:0090399 9.46 CDKN2A TP53
7 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.4 BMP2 BMP5
8 negative regulation of steroid biosynthetic process GO:0010894 9.26 BMP2 BMP5
9 negative regulation of aldosterone biosynthetic process GO:0032348 9.16 BMP2 BMP5
10 positive regulation of apoptotic process GO:0043065 9.02 BMP2 CDKN2A HSPD1 SFRP4 TP53
11 negative regulation of cortisol biosynthetic process GO:2000065 8.96 BMP2 BMP5

Molecular functions related to Squamous Cell Papilloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.26 CYP2E1 HSPD1 TBP TP53
2 BMP receptor binding GO:0070700 8.62 BMP2 BMP5

Sources for Squamous Cell Papilloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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