MCID: STC004
MIFTS: 39

Stachybotrys Chartarum

Categories: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

MalaCards integrated aliases for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 53
Stachybotrys Atra 53

Classifications:



Summaries for Stachybotrys Chartarum

MalaCards based summary : Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and b-cell growth factor. An important gene associated with Stachybotrys Chartarum is IL18 (Interleukin 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, testes and monocytes, and related phenotypes are cardiovascular system and immune system

Wikipedia : 76 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

Related Diseases for Stachybotrys Chartarum

Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 201)
# Related Disease Score Top Affiliating Genes
1 asthma 26.1 CCL2 CCL3 CCL5 CCL7 IL18 IL1A
2 b-cell growth factor 10.8 IL3 IL6
3 obesity-hypoventilation syndrome 10.7 CCL5 IL6
4 leukoregulin 10.6 CSF1 IL1A
5 leukomalacia 10.6 IL6 TNF
6 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
7 critical limb ischemia 10.6 IL6 TNF
8 streptococcal toxic-shock syndrome 10.6 IL6 TNF
9 recurrent corneal erosion 10.6 IL1B IL6
10 bagassosis 10.5 IL1B IL6
11 denture stomatitis 10.5 CCL2 IL6
12 periodontitis, chronic 10.5 IL1B IL6
13 anterior uveitis 10.5 CCL2 IL6
14 retinitis pigmentosa 55 10.5 IL6 TNF
15 acute cystitis 10.5 CCL2 IL18 IL6
16 chronic follicular conjunctivitis 10.5 IL1A IL1B
17 skin conditions 10.5 IL1A TNF
18 anca-associated vasculitis 10.5 IL6 TNF
19 radiculopathy 10.4 CCL5 IL1A IL6
20 null-cell leukemia 10.4 IL6 LIF TNF
21 fasciitis 10.4 IL18 IL6 TNF
22 rasmussen encephalitis 10.4 IL18 IL6 TNF
23 paracoccidioidomycosis 10.4 IL18 IL6 TNF
24 melioidosis 10.4 IL18 IL6 TNF
25 schnitzler syndrome 10.4 IL18 IL1B
26 uremic pruritus 10.4 IL18 IL1B IL6
27 cysticercosis 10.4 IL18 IL1B IL6
28 funisitis 10.4 IL1B IL6
29 post-transplant lymphoproliferative disease 10.3 IL1A IL6 TNF
30 anthracosis 10.3 CCL2 TNF
31 purulent labyrinthitis 10.3 CCL2 IL1B
32 respiratory syncytial virus infectious disease 10.3 CCL3 CCL5
33 viral meningitis 10.3 CCL2 CCL5 IL6
34 scorpion envenomation 10.3 CCL5 IL6 TNF
35 temporal arteritis 10.3 CCL2 CCL5 IL6
36 glossitis 10.3 IL1B IL6
37 staphylococcal toxic shock syndrome 10.3 IL1B TNF
38 euthyroid sick syndrome 10.3 IL1B IL6
39 autoimmune myocarditis 10.3 IL1B TNF
40 cytomegalovirus infection 10.3 CCL5 IL6 TNF
41 hemosiderosis 10.3
42 neuronitis 10.3
43 kashin-beck disease 10.3 IL1B TNF
44 pleural tuberculosis 10.3 CCL2 IL18 TNF
45 filariasis 10.3 CCL5 IL6 TNF
46 intervertebral disc disease 10.2 IL1A IL1B IL6
47 relapsing-remitting multiple sclerosis 10.2 CCL5 IL18 TNF
48 vulvar vestibulitis syndrome 10.2 IL1B TNF
49 scleritis 10.2 CCL2 TNF
50 alcoholic hepatitis 10.2 CCL2 IL6 TNF

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to Stachybotrys Chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CSF1 CXCL2 IL18 IL1A IL1B IL6
2 immune system MP:0005387 9.61 CCL2 CCL5 CSF1 IL18 IL1A IL1B
3 integument MP:0010771 9.17 CSF1 IL18 IL1A IL1B IL6 LIF

Drugs & Therapeutics for Stachybotrys Chartarum

Search Clinical Trials , NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

MalaCards organs/tissues related to Stachybotrys Chartarum:

41
Lung, Testes, Monocytes, Brain, Colon

Publications for Stachybotrys Chartarum

Articles related to Stachybotrys Chartarum:

(show top 50) (show all 133)
# Title Authors Year
1
A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum. ( 29288026 )
2018
2
Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum. ( 28530828 )
2017
3
A novel phenylspirodrimane dimer from cultures of the fungus Stachybotrys chartarum. ( 29252003 )
2017
4
Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum. ( 29279273 )
2017
5
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. ( 27476483 )
2016
6
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. ( 27097835 )
2016
7
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. ( 27997578 )
2016
8
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. ( 27148627 )
2016
9
Genome Sequence of Stachybotrys chartarum Strain 51-11. ( 26430036 )
2015
10
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. ( 26036596 )
2015
11
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. ( 24387683 )
2014
12
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. ( 25346283 )
2014
13
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. ( 24308451 )
2013
14
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. ( 24139181 )
2013
15
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. ( 21384497 )
2013
16
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. ( 23180821 )
2013
17
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. ( 24308675 )
2013
18
Allergen of the month--Stachybotrys chartarum. ( 22626607 )
2012
19
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. ( 22462447 )
2012
20
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. ( 22552393 )
2012
21
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. ( 21982832 )
2011
22
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. ( 21109751 )
2011
23
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. ( 21505873 )
2011
24
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. ( 21505872 )
2011
25
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. ( 21347692 )
2011
26
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. ( 20235799 )
2010
27
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. ( 20385656 )
2010
28
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. ( 20150440 )
2010
29
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. ( 19796210 )
2010
30
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. ( 20077192 )
2009
31
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. ( 19459771 )
2009
32
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. ( 20061240 )
2009
33
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. ( 18499423 )
2008
34
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. ( 18460072 )
2008
35
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18041646 )
2008
36
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. ( 18007011 )
2008
37
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. ( 18242638 )
2008
38
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. ( 18046622 )
2008
39
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. ( 17411351 )
2007
40
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18062486 )
2007
41
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. ( 17610048 )
2007
42
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. ( 17534970 )
2007
43
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. ( 17186382 )
2007
44
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( 17764432 )
2007
45
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. ( 17420079 )
2007
46
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. ( 17499865 )
2007
47
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. ( 17267247 )
2007
48
Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. ( 16322647 )
2006
49
Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. ( 17195998 )
2006
50
Solvent comparison in the isolation, solubilization, and toxicity of Stachybotrys chartarum spore trichothecene mycotoxins in an established in vitro luminescence protein translation inhibition assay. ( 16497399 )
2006

Variations for Stachybotrys Chartarum

Expression for Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for Stachybotrys Chartarum

Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
2
Show member pathways
13.82 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
3
Show member pathways
13.66 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4
Show member pathways
13.52 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
5
Show member pathways
13.36 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
6
Show member pathways
13.36 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
7
Show member pathways
13.33 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
8
Show member pathways
13.23 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
9
Show member pathways
13.07 CCL2 CCL3 CCL4 CCL5 CXCL2 IL18
10
Show member pathways
12.93 IL18 IL1A IL1B IL3 IL6 TNF
11
Show member pathways
12.93 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
12
Show member pathways
12.89 CCL2 CCL5 IL18 IL1A IL1B IL6
13
Show member pathways
12.84 CCL4 CCL5 IL18 IL1B IL6 TNF
14
Show member pathways
12.76 IL18 IL1A IL1B IL3 IL6 LIF
15
Show member pathways
12.74 IL1A IL1B IL3 IL6 TNF
16
Show member pathways
12.65 CCL2 IL18 IL1B IL6 TNF
17 12.63 CCL2 CCL5 IL1B IL3 TNF
18
Show member pathways
12.52 IL18 IL1A IL1B IL6 TNF
19
Show member pathways
12.45 CCL2 CCL5 CSF1 IL1B IL6 TNF
20
Show member pathways
12.44 IL1A IL1B IL6 TNF
21
Show member pathways
12.44 CCL2 CCL7 CXCL2 IL1B IL6 TNF
22
Show member pathways
12.35 IL18 IL1B IL6 LIF TNF
23 12.33 IL18 IL1A IL1B IL6 TNF
24
Show member pathways
12.32 IL1A IL1B IL6 TNF
25
Show member pathways
12.32 IL18 IL1A IL1B IL6 TNF
26 12.24 IL1A IL1B IL6 TNF
27 12.17 CCL2 IL1A IL1B TNF
28
Show member pathways
12.17 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
29 12.14 CCL2 CXCL2 IL1A IL1B IL6 TNF
30 12.12 CSF1 IL1A IL1B TNF
31
Show member pathways
12.12 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
32 12.12 CCL2 IL18 IL1A IL1B IL6 LIF
33 12.07 CSF1 IL3 IL6 TNF
34 12.07 CCL3 IL1A IL1B IL3 IL6
35 12.07 CCL2 CCL5 CSF1 CXCL2 IL1B IL6
36
Show member pathways
12.06 CCL3 CCL4 IL18 IL1B
37 12.04 IL3 IL6 LIF
38 12.04 CCL2 IL1A IL1B IL6 TNF
39 12.03 IL6 LIF TNF
40 12.02 CSF1 IL1A IL1B IL3 IL6 TNF
41 11.97 CCL4 CXCL2 IL1B TNF
42 11.97 CCL3 CCL4 CXCL2 IL18 IL1A IL1B
43 11.89 IL1B IL6 TNF
44 11.89 CCL3 IL18 IL1B TNF
45 11.87 IL1A IL1B IL6 TNF
46 11.85 CSF1 IL1B IL6 TNF
47
Show member pathways
11.82 CXCL2 IL1A IL1B IL6 TNF
48 11.76 CCL2 CCL3 CCL5 CSF1 IL18 IL1A
49 11.75 CXCL2 IL18 IL1B IL6 TNF
50 11.73 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2

GO Terms for Stachybotrys Chartarum

Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
2 extracellular space GO:0005615 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Name GO ID Score Top Affiliating Genes
1 cellular response to interleukin-1 GO:0071347 9.99 CCL2 CCL3 CCL4 CCL5 CCL7
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.98 CCL5 IL18 IL3 IL6 LIF
3 immune response GO:0006955 9.97 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
4 protein kinase B signaling GO:0043491 9.95 CCL2 CCL3 CCL5 IL1B TNF
5 cellular response to organic cyclic compound GO:0071407 9.95 CCL2 CCL3 CCL5 IL18 IL1B TNF
6 cell chemotaxis GO:0060326 9.94 CCL2 CCL3 CCL5 CXCL2
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL1B IL6 TNF
8 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 IL6 TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 CCL5 IL18 IL6 TNF
10 positive regulation of interleukin-6 production GO:0032755 9.92 IL1A IL1B IL6 TNF
11 lymphocyte chemotaxis GO:0048247 9.92 CCL2 CCL3 CCL4 CCL5 CCL7
12 positive regulation of DNA binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF
13 response to virus GO:0009615 9.91 CCL4 CCL5 TNF
14 chemokine-mediated signaling pathway GO:0070098 9.91 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
15 response to toxic substance GO:0009636 9.9 CCL3 CCL4 CCL5
16 cellular calcium ion homeostasis GO:0006874 9.9 CCL3 CCL5 CCL7
17 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 IL3 IL6 LIF
18 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.88 IL6 LIF TNF
19 positive regulation of inflammatory response GO:0050729 9.88 CCL3 CCL4 IL18
20 neutrophil chemotaxis GO:0030593 9.88 CCL2 CCL3 CCL4 CCL5 CCL7 IL1B
21 positive regulation of JNK cascade GO:0046330 9.87 IL1A IL1B TNF
22 regulation of insulin secretion GO:0050796 9.87 CCL5 IL1B TNF
23 positive regulation of T cell proliferation GO:0042102 9.86 CCL5 IL1B IL6
24 humoral immune response GO:0006959 9.85 CCL2 IL6 TNF
25 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.85 IL18 IL1B TNF
26 eosinophil chemotaxis GO:0048245 9.85 CCL2 CCL3 CCL4 CCL5 CCL7
27 monocyte chemotaxis GO:0002548 9.85 CCL2 CCL3 CCL4 CCL5 CCL7 IL6
28 positive regulation of interferon-gamma production GO:0032729 9.84 IL18 IL1B TNF
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 IL1A IL1B TNF
30 positive regulation of calcium ion transport GO:0051928 9.82 CCL3 CCL4 CCL5
31 macrophage chemotaxis GO:0048246 9.81 CCL2 CCL3 CCL5
32 negative regulation by host of viral transcription GO:0043922 9.8 CCL3 CCL4 CCL5
33 positive regulation of natural killer cell chemotaxis GO:2000503 9.8 CCL3 CCL4 CCL5 CCL7
34 lipopolysaccharide-mediated signaling pathway GO:0031663 9.8 CCL2 CCL3 CCL5 IL18 IL1B TNF
35 fever generation GO:0001660 9.78 IL1A IL1B IL3
36 cytokine-mediated signaling pathway GO:0019221 9.77 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
37 positive regulation of osteoclast differentiation GO:0045672 9.75 CSF1 TNF
38 positive regulation of chemokine production GO:0032722 9.74 IL6 TNF
39 positive regulation of calcium-mediated signaling GO:0050850 9.74 CCL3 CCL4
40 negative regulation of lipid catabolic process GO:0050995 9.74 IL1B TNF
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.74 IL1B TNF
42 positive regulation of calcium ion import GO:0090280 9.74 CCL2 CCL3
43 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.74 CSF1 IL18
44 positive regulation of macrophage differentiation GO:0045651 9.73 CSF1 LIF
45 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.72 IL1A IL1B
46 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.72 IL1B TNF
47 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.72 IL1A IL1B
48 positive regulation of macrophage chemotaxis GO:0010759 9.72 CCL5 CSF1
49 neutrophil activation GO:0042119 9.72 CCL5 IL18
50 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.71 IL18 IL1B

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.71 CSF1 IL3 IL6 LIF
2 CCR chemokine receptor binding GO:0048020 9.65 CCL2 CCL3 CCL4 CCL5 CCL7
3 interleukin-1 receptor binding GO:0005149 9.54 IL1A IL1B IL3
4 CCR5 chemokine receptor binding GO:0031730 9.5 CCL3 CCL4 CCL5
5 cytokine activity GO:0005125 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
6 phospholipase activator activity GO:0016004 9.46 CCL3 CCL5
7 CCR1 chemokine receptor binding GO:0031726 9.46 CCL3 CCL4 CCL5 CCL7
8 CCR2 chemokine receptor binding GO:0031727 9.43 CCL2 CCL7
9 chemokine activity GO:0008009 9.43 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2

Sources for Stachybotrys Chartarum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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