MCID: STC004
MIFTS: 34

Stachybotrys Chartarum

Categories: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

MalaCards integrated aliases for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 52
Stachybotrys Atra 52

Classifications:



Summaries for Stachybotrys Chartarum

MalaCards based summary : Stachybotrys Chartarum, also known as stachybotrys atra, is related to conjunctivitis and rhinitis. An important gene associated with Stachybotrys Chartarum is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, bone and liver, and related phenotype is immune system.

Wikipedia : 74 Stachybotrys chartarum,[note 1] (/staki?'b?tr?s/ /t???r't??r?m/, stak-ee-BO-tris char-TARE-?m) also... more...

Related Diseases for Stachybotrys Chartarum

Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 30.4 TNF IL6 CCL2
2 rhinitis 30.3 TNF IL6 CCL7 CCL5
3 allergic asthma 30.3 IL3 IL18 CCL5 CCL3
4 stomatitis 30.1 TNF IL6 IL1B
5 allergic hypersensitivity disease 30.0 TNF IL3 CCL7 CCL5 CCL3
6 pulmonary hypertension 29.6 TNF IL6 IL1B CCL2
7 extrinsic allergic alveolitis 29.2 IL6 IL1B IL18 CXCL2 CCL5 CCL3
8 lung disease 29.2 TNF IL6 IL1B IL18 CCL5 CCL3
9 interstitial lung disease 28.6 TNF IL6 IL1B IL1A IL18 CCL5
10 hemosiderosis 10.8
11 pulmonary hemosiderosis 10.6
12 sick building syndrome 10.6
13 respiratory syncytial virus infectious disease 10.4 CCL5 CCL3
14 allergic encephalomyelitis 10.4 CCL5 CCL3 CCL2
15 whiplash 10.3 CCL5 CCL4 CCL3
16 pulmonary hypertension, primary, 1 10.3
17 ataxia-telangiectasia 10.3
18 ataxia and polyneuropathy, adult-onset 10.3
19 lung cancer susceptibility 3 10.3
20 muscle hypertrophy 10.3
21 leukemia 10.3
22 pancytopenia 10.3
23 telangiectasis 10.3
24 hypereosinophilic syndrome 10.3
25 48,xyyy 10.3
26 cytokine deficiency 10.3
27 st anthony's fire 10.3
28 posttransplant acute limbic encephalitis 10.3
29 overgrowth syndrome 10.3
30 crescentic glomerulonephritis 10.3 CCL4 CCL3 CCL2
31 mast-cell leukemia 10.3 CCL5 CCL3 CCL2
32 leukoregulin 10.3 IL1A CSF1
33 autoimmune myocarditis 10.3 TNF CCL2
34 pulmonary eosinophilia 10.3 CCL7 CCL5 CCL3
35 spotted fever rickettsiosis 10.3 TNF CCL5
36 complement component 6 deficiency 10.2 IL1B CCL3
37 obesity-hypoventilation syndrome 10.2 IL6 CCL5
38 fuchs' heterochromic uveitis 10.2 IL6 CCL2
39 tuberculous meningitis 10.2 TNF CCL3 CCL2
40 periapical granuloma 10.2 CCL5 CCL4 CCL3 CCL2
41 staphylococcal toxic shock syndrome 10.1 TNF IL1B
42 orofacial granulomatosis 10.1 TNF CCL5 CCL3
43 pleurisy 10.1 TNF CCL3 CCL2
44 anaerobic pneumonia 10.1 IL6 CCL5
45 japanese encephalitis 10.1 TNF CCL5 CCL2
46 vulvar vestibulitis syndrome 10.1 TNF IL1B
47 kashin-beck disease 10.1 TNF IL1B
48 limbal stem cell deficiency 10.1 IL1B IL1A
49 macrophage activation syndrome 10.1 TNF IL18
50 spondylarthropathy 10.1 TNF CSF1

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to Stachybotrys Chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CCL2 CCL5 CSF1 IL18 IL1A IL1B

Drugs & Therapeutics for Stachybotrys Chartarum

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stachybotrys Induced Hemorrhage in the Developing Lung Completed NCT00011700

Search NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

MalaCards organs/tissues related to Stachybotrys Chartarum:

40
Lung, Bone, Liver, Monocytes, Eye, Thyroid, Testes

Publications for Stachybotrys Chartarum

Articles related to Stachybotrys Chartarum:

(show top 50) (show all 345)
# Title Authors PMID Year
1
Truncated satratoxin gene clusters in selected isolates of the atranone chemotype of Stachybotrys chartarum (Ehrenb.) S. Hughes. 61
31435889 2020
2
Reisolation and NMR characterization of the satratoxins G and H. 61
31692051 2020
3
Cultivation and aerosolization of Stachybotrys chartarum for modeling pulmonary inhalation exposure. 61
31874574 2019
4
Bistachybotrysin K, one new phenylspirodrimane dimer from Stachybotrys chartarum with potent cytotoxic activity. 61
31738087 2019
5
Inhalation of Stachybotrys chartarum Fragments Induces Pulmonary Arterial Remodeling. 61
31671270 2019
6
Three new phenylspirodrimane derivatives with inhibitory effect towards potassium channel Kv1.3 from the fungus Stachybotrys chartarum. 61
30614271 2019
7
Antimicrobial Dolabellanes and Atranones from a Marine-Derived Strain of the Toxigenic Fungus Stachybotrys chartarum. 61
31265296 2019
8
Bistachybotrysins F-J, five new phenylspirodrimane dimers with a central cyclopentanone linkage from Stachybotrys chartarum. 61
31051194 2019
9
Molecular and bioinformatics analyses reveal two differentially expressed intracellular GH1 β-glucosidases from the rare alkalophilic fungus Stachybotrys microspora. 61
30974199 2019
10
Mold burden in house dust and its relationship with asthma control. 61
30961954 2019
11
Pro-Inflammatory Responses in Human Bronchial Epithelial Cells Induced by Spores and Hyphal Fragments of Common Damp Indoor Molds. 61
30917597 2019
12
Portable paper-based colorimetric nanoprobe for the detection of Stachybotrys chartarum using peptide labeled magnetic nanoparticles. 61
30850897 2019
13
A novel phenylspirodrimane dimer from cultures of the fungus Stachybotrys chartarum. 61
29252003 2018
14
Stachybotrychromenes A-C: novel cytotoxic meroterpenoids from Stachybotrys sp. 61
29549547 2018
15
Ketamine intervention limits pathogen expansion in vitro. 61
29365093 2018
16
Novel mold-resistant building materials impregnated with thermally reduced nano-silver. 61
29227564 2018
17
A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum. 61
29288026 2018
18
Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum. 61
29279273 2018
19
MicroRNA Regulation of Host Immune Responses following Fungal Exposure. 61
29467760 2018
20
Occurrence and hygienic/allergological relevance of mould from point of view of the environmental medicine. 61
31826039 2018
21
Characterization and pro-inflammatory responses of spore and hyphae samples from various mold species. 61
28922584 2018
22
Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings. 61
28795317 2017
23
Antimicrobial activity of water and acetone extracts of some Eucomis taxa. 61
29080618 2017
24
Aerosolization of Mycotoxins after Growth of Toxinogenic Fungi on Wallpaper. 61
28646113 2017
25
Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum. 61
28530828 2017
26
Isolation and characterization of roridin E. 61
27737497 2017
27
Pre-contamination of new gypsum wallboard with potentially harmful fungal species. 61
26970063 2017
28
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. 61
27476483 2016
29
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response from Type 1 to Type 2. 61
27148627 2016
30
[Antagonistic Properties of Microscopic Fungi Isolated from Plasterboard]. 61
30141873 2016
31
Generic aspects of the airborne spread of human pathogens indoors and emerging air decontamination technologies. 61
27590695 2016
32
Stachybotrys mycotoxins: from culture extracts to dust samples. 61
27255106 2016
33
[Expression in Aspergillus niger and characterization of β-mannanases from Stachybotrys chartarum]. 61
29738194 2016
34
Recombinant expression of a GH12 β-glucanase carrying its own signal peptide from Stachybotrys atra in yeast and filamentous fungi. 61
27339304 2016
35
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. 61
27097835 2016
36
Reversal of Refractory Ulcerative Colitis and Severe Chronic Fatigue Syndrome Symptoms Arising from Immune Disturbance in an HLA-DR/DQ Genetically Susceptible Individual with Multiple Biotoxin Exposures. 61
27165859 2016
37
Generation and Characterization of Indoor Fungal Aerosols for Inhalation Studies. 61
26921421 2016
38
Measurement of macrocyclic trichothecene in floor dust of water-damaged buildings using gas chromatography/tandem mass spectrometry-dust matrix effects. 61
26853932 2016
39
Occupational exposure to fungi and particles in animal feed industry. 61
27221292 2016
40
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. 61
27997578 2016
41
Rhinitis, Ocular, Throat and Dermal Symptoms, Headache and Tiredness among Students in Schools from Johor Bahru, Malaysia: Associations with Fungal DNA and Mycotoxins in Classroom Dust. 61
26829324 2016
42
Genome Sequence of Stachybotrys chartarum Strain 51-11. 61
26430036 2015
43
The effect of anatase and rutile crystallites isolated from titania P25 photocatalyst on growth of selected mould fungi. 61
26177513 2015
44
EFFECT OF WATER ACTIVITY AND TITANIA P25 PHOTOCATALYST ON INACTIVATION OF PATHOGENIC FUNGI--CONTRIBUTION TO THE PROTECTION OF PUBLIC HEALTH. 61
26615661 2015
45
Bioconversion of FR901459, a novel derivative of cyclosporin A, by Lentzea sp. 7887. 61
25783225 2015
46
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. 61
26036596 2015
47
Antifungal properties of silver nanoparticles against indoor mould growth. 61
25847174 2015
48
Fungal burden in waste industry: an occupational risk to be solved. 61
25796518 2015
49
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. 61
25346283 2015
50
Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses. 61
26010737 2015

Variations for Stachybotrys Chartarum

Expression for Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for Stachybotrys Chartarum

Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 TNF LIF IL6 IL3 IL1B IL1A
2
Show member pathways
13.84 TNF LIF IL6 IL3 IL1B IL1A
3
Show member pathways
13.7 TNF LIF IL6 IL3 IL1B IL1A
4
Show member pathways
13.59 TNF IL6 IL3 IL1B IL1A IL18
5
Show member pathways
13.4 TNF LIF IL6 IL3 IL1B IL1A
6
Show member pathways
13.21 TNF IL6 IL1B IL18 CCL5 CCL4
7
Show member pathways
13.07 TNF LIF IL6 IL3 IL1B IL1A
8
Show member pathways
13.03 TNF IL6 IL1B CXCL2 CCL5 CCL4
9
Show member pathways
12.94 CXCL2 CCL7 CCL5 CCL4 CCL3 CCL2
10
Show member pathways
12.92 TNF IL6 IL1B IL1A IL18 CCL5
11
Show member pathways
12.88 TNF IL6 IL3 IL1B IL1A
12
Show member pathways
12.84 TNF IL6 IL1B IL18 CCL5 CCL4
13 12.83 TNF IL6 IL1B CCL5 CCL2
14
Show member pathways
12.75 TNF IL6 IL3 IL1B IL1A
15
Show member pathways
12.66 TNF IL6 IL1B IL1A IL18
16
Show member pathways
12.66 TNF IL6 IL1B IL18 CCL2
17 12.63 TNF IL3 IL1B CCL5 CCL2
18
Show member pathways
12.62 TNF LIF IL6 IL3 IL1B IL1A
19
Show member pathways
12.59 TNF IL6 IL1B IL1A
20
Show member pathways
12.45 TNF IL6 IL1B CXCL2 CCL7 CCL2
21
Show member pathways
12.45 TNF IL6 IL1B CSF1 CCL5 CCL2
22 12.42 TNF IL1B IL18 CCL5
23
Show member pathways
12.37 TNF IL6 IL3 IL1B IL1A IL18
24 12.37 TNF IL6 IL1B IL18 CXCL2 CCL5
25
Show member pathways
12.36 TNF IL6 IL18 CXCL2 CSF1 CCL7
26
Show member pathways
12.34 TNF IL6 IL1B IL1A
27 12.34 TNF IL6 IL1B IL18
28 12.34 TNF IL6 IL1B IL1A IL18
29
Show member pathways
12.33 TNF IL6 IL1B IL1A IL18
30 12.24 TNF IL6 IL1B IL1A
31 12.17 TNF IL1B IL1A CCL2
32 12.15 TNF IL6 IL1B IL18 CCL2
33 12.15 TNF LIF IL6 IL1B IL1A IL18
34 12.15 TNF LIF IL6 IL1B CXCL2 CSF1
35
Show member pathways
12.14 TNF IL6 IL1B IL18
36 12.14 TNF IL6 IL1B IL1A CXCL2 CCL2
37 12.13 TNF IL1B IL1A CSF1
38 12.08 TNF IL6 IL3 CSF1
39
Show member pathways
12.07 IL1B IL18 CCL4 CCL3
40 12.07 IL6 IL3 IL1B IL1A CCL3
41 12.05 LIF IL6 IL3
42 12.05 TNF IL6 IL3 IL1B IL1A CSF1
43 12.04 TNF LIF IL6
44 12.04 TNF IL6 IL1B IL1A CCL2
45 12.04 TNF IL6 IL1B IL1A IL18 CXCL2
46
Show member pathways
12.02 TNF IL6 IL1B
47 12.02 TNF IL1B CXCL2 CCL4
48 12.01 TNF IL6 IL1B CXCL2
49 11.98 IL6 IL1B IL1A IL18 CXCL2 CCL4
50 11.9 TNF IL1B IL18 CCL3

GO Terms for Stachybotrys Chartarum

Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNF LIF IL6 IL3 IL1B IL1A
2 extracellular space GO:0005615 9.47 TNF LIF IL6 IL3 IL1B IL1A

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.31 IL6 IL1B IL18 CXCL2 CSF1 CCL7
2 G protein-coupled receptor signaling pathway GO:0007186 10.21 CXCL2 CCL7 CCL5 CCL4 CCL3 CCL2
3 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 TNF LIF IL6 IL1B IL1A IL18
4 positive regulation of gene expression GO:0010628 10.15 TNF LIF IL6 IL1B IL1A IL18
5 positive regulation of cell proliferation GO:0008284 10.12 LIF IL6 IL3 IL1B CSF1
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.08 TNF CCL7 CCL5 CCL4 CCL3 CCL2
7 MAPK cascade GO:0000165 10.08 TNF IL3 IL1B IL18 CCL5 CCL3
8 positive regulation of GTPase activity GO:0043547 10.07 CCL7 CCL5 CCL4 CCL3 CCL2
9 positive regulation of cell migration GO:0030335 10.05 IL1B CSF1 CCL7 CCL5 CCL3
10 cellular response to lipopolysaccharide GO:0071222 10.05 TNF IL6 IL1B IL1A CXCL2 CCL2
11 cell-cell signaling GO:0007267 10.05 IL3 IL1B IL18 CCL7 CCL5 CCL4
12 chemotaxis GO:0006935 10.04 CXCL2 CCL7 CCL5 CCL4 CCL3 CCL2
13 cellular response to tumor necrosis factor GO:0071356 10.02 CCL7 CCL5 CCL4 CCL3 CCL2
14 cellular response to interferon-gamma GO:0071346 10 CCL7 CCL5 CCL4 CCL3 CCL2
15 cellular response to interleukin-1 GO:0071347 9.99 CCL7 CCL5 CCL4 CCL3 CCL2
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.98 TNF IL6 IL1B IL18
17 cell chemotaxis GO:0060326 9.96 CXCL2 CCL5 CCL3 CCL2
18 positive regulation of inflammatory response GO:0050729 9.95 TNF IL1B IL18 CCL3
19 positive regulation of interleukin-6 production GO:0032755 9.93 TNF IL6 IL1B IL1A
20 chemokine-mediated signaling pathway GO:0070098 9.93 CXCL2 CCL7 CCL5 CCL4 CCL3 CCL2
21 inflammatory response GO:0006954 9.93 TNF IL6 IL1B IL1A IL18 CXCL2
22 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNF IL6 IL1B
23 response to virus GO:0009615 9.92 TNF CCL5 CCL4
24 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 TNF IL6 IL18 CCL5
25 protein kinase B signaling GO:0043491 9.92 TNF IL1B CCL5 CCL3 CCL2
26 cellular calcium ion homeostasis GO:0006874 9.91 CCL7 CCL5 CCL3
27 response to toxic substance GO:0009636 9.91 CCL5 CCL4 CCL3
28 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.91 LIF IL6 IL3
29 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF LIF IL6 IL3 IL18 CCL5
30 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.9 TNF IL18 CCL5
31 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.9 TNF LIF IL6
32 positive regulation of JNK cascade GO:0046330 9.9 TNF IL1B IL1A
33 lymphocyte chemotaxis GO:0048247 9.89 CCL7 CCL5 CCL4 CCL3 CCL2
34 regulation of insulin secretion GO:0050796 9.88 TNF IL1B CCL5
35 positive regulation of T cell proliferation GO:0042102 9.88 IL6 IL1B CCL5
36 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TNF IL1B IL18
37 eosinophil chemotaxis GO:0048245 9.88 CCL7 CCL5 CCL3 CCL2
38 cellular response to organic cyclic compound GO:0071407 9.88 TNF IL1B IL18 CCL5 CCL3 CCL2
39 humoral immune response GO:0006959 9.87 TNF IL6 CCL2
40 positive regulation of interferon-gamma production GO:0032729 9.86 TNF IL1B IL18
41 positive regulation of neuroinflammatory response GO:0150078 9.86 TNF IL6 IL1B IL18
42 neutrophil chemotaxis GO:0030593 9.86 IL1B IL1A CXCL2 CCL7 CCL5 CCL4
43 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.85 TNF IL1B IL1A
44 positive regulation of calcium ion transport GO:0051928 9.85 CCL5 CCL4 CCL3
45 monocyte chemotaxis GO:0002548 9.85 IL6 CCL7 CCL5 CCL4 CCL3 CCL2
46 positive regulation of JAK-STAT cascade GO:0046427 9.84 TNF IL6 CCL5
47 positive regulation of vascular endothelial growth factor production GO:0010575 9.84 IL6 IL1B IL1A
48 negative regulation of neurogenesis GO:0050768 9.83 TNF IL6 IL1B
49 positive regulation of glial cell proliferation GO:0060252 9.82 TNF IL6 IL1B
50 macrophage chemotaxis GO:0048246 9.81 CCL5 CCL3 CCL2

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.67 LIF IL6 IL3 CSF1
2 CCR chemokine receptor binding GO:0048020 9.65 CCL7 CCL5 CCL4 CCL3 CCL2
3 CCR5 chemokine receptor binding GO:0031730 9.5 CCL5 CCL4 CCL3
4 cytokine activity GO:0005125 9.47 TNF LIF IL6 IL3 IL1B IL1A
5 interleukin-1 receptor binding GO:0005149 9.46 IL1B IL1A
6 CCR1 chemokine receptor binding GO:0031726 9.46 CCL7 CCL5 CCL4 CCL3
7 phospholipase activator activity GO:0016004 9.43 CCL5 CCL3
8 chemokine activity GO:0008009 9.43 CXCL2 CCL7 CCL5 CCL4 CCL3 CCL2
9 CCR2 chemokine receptor binding GO:0031727 9.4 CCL7 CCL2

Sources for Stachybotrys Chartarum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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