MCID: STC004
MIFTS: 41

Stachybotrys Chartarum

Categories: Rare diseases

Aliases & Classifications for Stachybotrys Chartarum

MalaCards integrated aliases for Stachybotrys Chartarum:

Name: Stachybotrys Chartarum 53
Stachybotrys Atra 53

Classifications:



Summaries for Stachybotrys Chartarum

MalaCards based summary : Stachybotrys Chartarum, also known as stachybotrys atra, is related to asthma and hemosiderosis. An important gene associated with Stachybotrys Chartarum is CCL2 (C-C Motif Chemokine Ligand 2), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include lung, monocytes and bone, and related phenotypes are cardiovascular system and immune system

Wikipedia : 76 Stachybotrys chartarum, also called Stachybotrys atra, Stachybotrys alternans or Stilbospora chartarum,... more...

Related Diseases for Stachybotrys Chartarum

Diseases related to Stachybotrys Chartarum via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 asthma 29.0 CCL2 CCL3 CCL5 CCL7 IL18 IL1A
2 hemosiderosis 10.4
3 denture stomatitis 10.3 CCL2 IL6
4 pulmonary hemosiderosis 10.3
5 pulmonary hypertension, primary, 1 10.3
6 sick building syndrome 10.3
7 rhinitis 10.3
8 allergic asthma 10.3
9 b-cell growth factor 10.3 IL3 IL6
10 leukoregulin 10.3 CSF1 IL1A
11 erdheim-chester disease 10.2 CCL2 IL1B
12 anthracosis 10.2 CCL2 TNF
13 scleritis 10.2 CCL2 TNF
14 funisitis 10.2 IL1B IL6
15 euthyroid sick syndrome 10.2 IL1B IL6
16 schnitzler syndrome 10.2 IL18 IL1B
17 retinitis pigmentosa 55 10.2 IL6 TNF
18 critical limb ischemia 10.2 IL6 TNF
19 juvenile ankylosing spondylitis 10.2 IL6 TNF
20 anca-associated vasculitis 10.2 IL6 TNF
21 anterior uveitis 10.2 IL6 TNF
22 posterior urethral valves 10.2 IL6 TNF
23 cardiogenic shock 10.2 IL6 TNF
24 streptococcal toxic-shock syndrome 10.2 IL6 TNF
25 respiratory syncytial virus infectious disease 10.2 CCL3 CCL5
26 viral meningitis 10.2 CCL2 CCL5 IL6
27 skin conditions 10.2 IL1A TNF
28 chronic graft versus host disease 10.2 IL1A TNF
29 yellow fever 10.2 CCL2 CCL5 IL6
30 encephalitis 10.1 CCL2 CCL5 IL1B
31 retinitis pigmentosa 60 10.1 IL1B TNF
32 kashin-beck disease 10.1 IL1B TNF
33 burns 10.1 IL1B TNF
34 opisthorchiasis 10.1 IL1B TNF
35 rheumatoid lung disease 10.1 IL1B TNF
36 haemophilus influenzae 10.1 IL1B TNF
37 vulvar vestibulitis syndrome 10.1 IL1B TNF
38 obesity-hypoventilation syndrome 10.1 CCL5 IL6
39 chronic follicular conjunctivitis 10.1 IL1A IL1B
40 acute cystitis 10.1 CCL2 IL18 IL6
41 japanese spotted fever 10.1 CCL2 CCL4
42 recurrent corneal erosion 10.1 IL1B IL6
43 acute cervicitis 10.1 CCL4 CCL5
44 alcoholic gastritis 10.1 IL18 IL1B
45 bagassosis 10.1 IL1B IL6
46 exudative glomerulonephritis 10.1 IL1B TNF
47 glomerulonephritis 10.1 CCL2 CSF1 IL1B
48 scorpion envenomation 10.1 CCL5 IL6 TNF
49 severe acute respiratory syndrome 10.1 CCL2 CCL5 TNF
50 leukomalacia 10.1 IL6 TNF

Graphical network of the top 20 diseases related to Stachybotrys Chartarum:



Diseases related to Stachybotrys Chartarum

Symptoms & Phenotypes for Stachybotrys Chartarum

MGI Mouse Phenotypes related to Stachybotrys Chartarum:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CSF1 CXCL2 IL18 IL1A IL1B IL6
2 immune system MP:0005387 9.61 CCL2 CCL5 CSF1 IL18 IL1A IL1B
3 integument MP:0010771 9.17 CSF1 IL18 IL1A IL1B IL6 LIF

Drugs & Therapeutics for Stachybotrys Chartarum

Search Clinical Trials , NIH Clinical Center for Stachybotrys Chartarum

Genetic Tests for Stachybotrys Chartarum

Anatomical Context for Stachybotrys Chartarum

MalaCards organs/tissues related to Stachybotrys Chartarum:

41
Lung, Monocytes, Bone, Heart, Lymph Node, Eye, Spinal Cord

Publications for Stachybotrys Chartarum

Articles related to Stachybotrys Chartarum:

(show top 50) (show all 169)
# Title Authors Year
1
A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum. ( 29288026 )
2018
2
Stachybotrysins A-G, Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum. ( 28530828 )
2017
3
A novel phenylspirodrimane dimer from cultures of the fungus Stachybotrys chartarum. ( 29252003 )
2017
4
Bistachybotrysins A-C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum. ( 29279273 )
2017
5
Visualization of the structural changes in plywood and gypsum board during the growth of Chaetomium globosum and Stachybotrys chartarum. ( 27476483 )
2016
6
Biological responses of Raw 264.7 macrophage exposed to two strains of Stachybotrys chartarum spores grown on four different wallboard types. ( 27097835 )
2016
7
Identification and Characterisation of a Novel Protein FIP-sch3 from Stachybotrys chartarum. ( 27997578 )
2016
8
Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response From Type 1 to Type 2. ( 27148627 )
2016
9
Recombinant expression of a GH12 β-glucanase carrying its own signal peptide from Stachybotrys atra in yeast and filamentous fungi. ( 27339304 )
2016
10
Genome Sequence of Stachybotrys chartarum Strain 51-11. ( 26430036 )
2015
11
MALDI-TOF mass spectrometry fingerprinting: A diagnostic tool to differentiate dematiaceous fungi Stachybotrys chartarum and Stachybotrys chlorohalonata. ( 26036596 )
2015
12
Chartarlactams A-P, Phenylspirodrimanes from the Sponge-Associated Fungus Stachybotrys chartarum with Antihyperlipidemic Activities. ( 24387683 )
2014
13
Occurrence of Stachybotrys chartarum chemotype S in dried culinary herbs. ( 25346283 )
2014
14
Microbial volatile organic compound emissions from Stachybotrys chartarum growing on gypsum wallboard and ceiling tile. ( 24308451 )
2013
15
Study on fungi in archives of offices, with a particular focus on Stachybotrys chartarum. ( 24139181 )
2013
16
Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. ( 21384497 )
2013
17
TLR9-dependent IL-23/IL-17 is required for the generation of Stachybotrys chartarum-induced hypersensitivity pneumonitis. ( 23180821 )
2013
18
Phenylspirodrimanes with Anti-HIV Activity from the Sponge-Derived Fungus Stachybotrys chartarum MXH-X73. ( 24308675 )
2013
19
Allergen of the month--Stachybotrys chartarum. ( 22626607 )
2012
20
Recurrence of Stachybotrys chartarum during mycological and toxicological study of bioaerosols collected in a dairy cattle shed. ( 22462447 )
2012
21
Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. ( 22552393 )
2012
22
Expression of novel β-glucanase Cel12A from Stachybotrys atra in bacterial and fungal hosts. ( 22385626 )
2012
23
Stachybotrys chartarum-induced hypersensitivity pneumonitis is TLR9 dependent. ( 21982832 )
2011
24
Characterization of human antigenic proteins SchS21 and SchS34 from Stachybotrys chartarum. ( 21109751 )
2011
25
Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. ( 21505873 )
2011
26
Guest editorial--novel insights into the pathology of Stachybotrys chartarum. ( 21505872 )
2011
27
The influence of water activity and temperature on germination, growth and sporulation of Stachybotrys chartarum strains. ( 21347692 )
2011
28
The relative allergenicity of Stachybotrys chartarum compared to house dust mite extracts in a mouse model. ( 20235799 )
2010
29
Pulmonary responses to Stachybotrys chartarum and its toxins: mouse strain affects clearance and macrophage cytotoxicity. ( 20385656 )
2010
30
DNA damage and DNA damage responses in THP-1 monocytes after exposure to spores of either Stachybotrys chartarum or Aspergillus versicolor or to T-2 toxin. ( 20150440 )
2010
31
Symptoms after mould exposure including Stachybotrys chartarum, and comparison with darkroom disease. ( 19796210 )
2010
32
Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum. ( 20077192 )
2009
33
Co-cultivated damp building related microbes Streptomyces californicus and Stachybotrys chartarum induce immunotoxic and genotoxic responses via oxidative stress. ( 19459771 )
2009
34
Inflammatory and haematotoxic potential of indoor Stachybotrys chartarum (Ehrenb.) Hughes metabolites. ( 20061240 )
2009
35
Detection of Stachybotrys chartarum using rRNA, tri5, and beta-tubulin primers and determining their relative copy number by real-time PCR. ( 18499423 )
2008
36
Inhalation of Stachybotrys chartarum causes pulmonary arterial hypertension in mice. ( 18460072 )
2008
37
Testing antimicrobial paint efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18041646 )
2008
38
Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. ( 18007011 )
2008
39
Characterization of monoclonal antibodies to an antigenic protein from Stachybotrys chartarum and its measurement in house dust. ( 18242638 )
2008
40
Immunohistochemical and immunocytochemical detection of SchS34 antigen in Stachybotrys chartarum spores and spore impacted mouse lungs. ( 18046622 )
2008
41
Stachybotrys atra BP-A produces alkali-resistant and thermostable cellulases. ( 18454347 )
2008
42
An in vitro study of the toxic effects of Stachybotrys chartarum metabolites on lung cells. ( 17411351 )
2007
43
Testing antimicrobial cleaner efficacy on gypsum wallboard contaminated with Stachybotrys chartarum. ( 18062486 )
2007
44
The role of fungal proteinases in pathophysiology of Stachybotrys chartarum. ( 17610048 )
2007
45
DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins. ( 17534970 )
2007
46
Global gene expression changes underlying Stachybotrys chartarum toxin-induced apoptosis in murine alveolar macrophages: evidence of multiple signal transduction pathways. ( 17186382 )
2007
47
Acute pulmonary hemorrhage during isoflurane anesthesia in two cats exposed to toxic black mold (Stachybotrys chartarum). ( 17764432 )
2007
48
DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. ( 17420079 )
2007
49
Comparison of four different methods for extraction of Stachybotrys chartarum spore DNA and verification by real-time PCR. ( 17499865 )
2007
50
Biomechanics of conidial dispersal in the toxic mold Stachybotrys chartarum. ( 17267247 )
2007

Variations for Stachybotrys Chartarum

Expression for Stachybotrys Chartarum

Search GEO for disease gene expression data for Stachybotrys Chartarum.

Pathways for Stachybotrys Chartarum

Pathways related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
2
Show member pathways
13.86 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
3
Show member pathways
13.71 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
4
Show member pathways
13.6 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
5
Show member pathways
13.45 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
6
Show member pathways
13.4 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
7
Show member pathways
13.36 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
8
Show member pathways
13.28 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
9
Show member pathways
13.14 CCL2 CCL3 CCL4 CCL5 CXCL2 IL1B
10
Show member pathways
13.09 CCL2 CCL3 CCL4 CCL5 CXCL2 IL18
11
Show member pathways
12.94 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
12
Show member pathways
12.93 IL18 IL1A IL1B IL3 IL6 TNF
13
Show member pathways
12.9 CCL2 CCL5 IL18 IL1A IL1B IL6
14
Show member pathways
12.84 CCL4 CCL5 IL18 IL1B IL6 TNF
15
Show member pathways
12.75 IL1A IL1B IL3 IL6 TNF
16
Show member pathways
12.66 IL18 IL1A IL1B IL6 TNF
17
Show member pathways
12.66 CCL2 IL18 IL1B IL6 TNF
18 12.63 CCL2 CCL5 IL1B IL3 TNF
19
Show member pathways
12.46 CCL2 CCL5 CSF1 IL1B IL6 TNF
20
Show member pathways
12.46 CCL2 CCL7 CXCL2 IL1B IL6 TNF
21
Show member pathways
12.45 IL1A IL1B IL6 TNF
22
Show member pathways
12.37 IL18 IL1A IL1B IL3 IL6 TNF
23
Show member pathways
12.34 IL1A IL1B IL6 TNF
24 12.34 IL18 IL1A IL1B IL6 TNF
25
Show member pathways
12.34 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
26
Show member pathways
12.33 IL18 IL1A IL1B IL6 TNF
27 12.25 IL1A IL1B IL6 TNF
28
Show member pathways
12.22 CCL2 CCL3 CCL4 CCL5 CCL7 IL18
29 12.17 CCL2 IL1A IL1B TNF
30 12.16 CCL2 IL18 IL1A IL1B IL6 LIF
31 12.15 CCL2 CXCL2 IL1A IL1B IL6 TNF
32
Show member pathways
12.14 IL18 IL1B IL6 TNF
33 12.14 CCL2 CCL5 CSF1 CXCL2 IL1B IL6
34 12.13 CSF1 IL1A IL1B TNF
35
Show member pathways
12.13 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
36 12.09 CCL3 IL1A IL1B IL3 IL6
37 12.08 CSF1 IL3 IL6 TNF
38
Show member pathways
12.07 CCL3 CCL4 IL18 IL1B
39 12.05 IL3 IL6 LIF
40 12.05 CCL2 IL1A IL1B IL6 TNF
41 12.04 IL6 LIF TNF
42 12.04 CSF1 IL1A IL1B IL3 IL6 TNF
43
Show member pathways
12.02 IL1B IL6 TNF
44 12.01 CCL3 CCL4 CXCL2 IL18 IL1A IL1B
45 11.98 CCL4 CXCL2 IL1B TNF
46 11.91 CCL3 IL18 IL1B TNF
47 11.9 IL1B IL6 TNF
48 11.88 IL1A IL1B IL6 TNF
49 11.87 CSF1 IL1B IL6 TNF
50 11.86 CCL2 CCL3 CCL5 CSF1 IL18 IL1A

GO Terms for Stachybotrys Chartarum

Cellular components related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
2 extracellular space GO:0005615 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Biological processes related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.99 CCL5 IL18 IL3 IL6 LIF
2 cytokine-mediated signaling pathway GO:0019221 9.97 CCL2 CCL3 CCL4 CCL5 CSF1 CXCL2
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.96 IL18 IL1B IL6 TNF
4 protein kinase B signaling GO:0043491 9.95 CCL2 CCL3 CCL5 IL1B TNF
5 chemokine-mediated signaling pathway GO:0070098 9.95 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
6 regulation of cell shape GO:0008360 9.93 CCL2 CCL3 CCL7
7 cellular response to organic cyclic compound GO:0071407 9.93 CCL2 CCL3 CCL5 IL18 IL1B TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 IL1B IL6 TNF
9 response to virus GO:0009615 9.92 CCL4 CCL5 TNF
10 positive regulation of smooth muscle cell proliferation GO:0048661 9.92 CCL5 IL18 IL6 TNF
11 lymphocyte chemotaxis GO:0048247 9.92 CCL2 CCL3 CCL4 CCL5 CCL7
12 cellular calcium ion homeostasis GO:0006874 9.91 CCL3 CCL5 CCL7
13 response to toxic substance GO:0009636 9.91 CCL3 CCL4 CCL5
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 IL3 IL6 LIF
15 cell chemotaxis GO:0060326 9.9 CCL2 CCL3 CCL5
16 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.9 IL6 LIF TNF
17 positive regulation of inflammatory response GO:0050729 9.89 CCL3 IL18 TNF
18 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.89 CCL5 IL18 TNF
19 regulation of insulin secretion GO:0050796 9.88 CCL5 IL1B TNF
20 response to glucocorticoid GO:0051384 9.88 IL1B IL6 TNF
21 monocyte chemotaxis GO:0002548 9.88 CCL2 CCL3 CCL4 CCL5 CCL7 IL6
22 positive regulation of T cell proliferation GO:0042102 9.87 CCL5 IL1B IL6
23 positive regulation of interleukin-6 production GO:0032755 9.87 IL1B IL6 TNF
24 humoral immune response GO:0006959 9.87 CCL2 IL6 TNF
25 neutrophil chemotaxis GO:0030593 9.87 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
26 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.86 IL18 IL1B TNF
27 positive regulation of interferon-gamma production GO:0032729 9.85 IL18 IL1B TNF
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 CCL2 CCL3 CCL5 IL18 IL1B TNF
29 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.83 IL1A IL1B TNF
30 positive regulation of calcium ion transport GO:0051928 9.83 CCL3 CCL4 CCL5
31 eosinophil chemotaxis GO:0048245 9.83 CCL2 CCL3 CCL4 CCL5 CCL7
32 negative regulation of neurogenesis GO:0050768 9.82 IL1B IL6 TNF
33 positive regulation of glial cell proliferation GO:0060252 9.81 IL1B IL6 TNF
34 macrophage chemotaxis GO:0048246 9.81 CCL2 CCL3 CCL5
35 positive regulation of natural killer cell chemotaxis GO:2000503 9.81 CCL3 CCL4 CCL5 CCL7
36 negative regulation by host of viral transcription GO:0043922 9.8 CCL3 CCL4 CCL5
37 positive regulation of neuroinflammatory response GO:0150078 9.8 IL18 IL1B IL6 TNF
38 immune response GO:0006955 9.77 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
39 positive regulation of osteoclast differentiation GO:0045672 9.76 CSF1 TNF
40 positive regulation of chemokine production GO:0032722 9.76 IL6 TNF
41 negative regulation of lipid catabolic process GO:0050995 9.75 IL1B TNF
42 positive regulation of calcium-mediated signaling GO:0050850 9.75 CCL3 CCL4
43 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.75 CSF1 IL18
44 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.75 IL1B TNF
45 positive regulation of calcium ion import GO:0090280 9.75 CCL2 CCL3
46 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.75 IL1B TNF
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.75 IL1B TNF
48 positive regulation of macrophage chemotaxis GO:0010759 9.74 CCL5 CSF1
49 positive regulation of macrophage differentiation GO:0045651 9.74 CSF1 LIF
50 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.74 IL1A IL1B

Molecular functions related to Stachybotrys Chartarum according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.67 CSF1 IL3 IL6 LIF
2 CCR chemokine receptor binding GO:0048020 9.65 CCL2 CCL3 CCL4 CCL5 CCL7
3 CCR5 chemokine receptor binding GO:0031730 9.5 CCL3 CCL4 CCL5
4 interleukin-1 receptor binding GO:0005149 9.48 IL1A IL1B
5 cytokine activity GO:0005125 9.47 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1
6 CCR1 chemokine receptor binding GO:0031726 9.46 CCL3 CCL4 CCL5 CCL7
7 CCR2 chemokine receptor binding GO:0031727 9.43 CCL2 CCL7
8 chemokine activity GO:0008009 9.43 CCL2 CCL3 CCL4 CCL5 CCL7 CXCL2
9 phospholipase activator activity GO:0016004 9.4 CCL3 CCL5
10 protein binding GO:0005515 10.27 CCL2 CCL3 CCL4 CCL5 CCL7 CSF1

Sources for Stachybotrys Chartarum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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