MCID: STP004
MIFTS: 45

Staphylococcal Toxic Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

MalaCards integrated aliases for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 20 71
Bacterial Toxic-Shock Syndrome 20 58
Staphylococcal Toxic-Shock Syndrome 58
Staphylococcal Tss 58
Bacterial Tss 58

Characteristics:

Orphanet epidemiological data:

58
bacterial toxic-shock syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
staphylococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Staphylococcal Toxic Shock Syndrome

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 36234DefinitionBacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins, usually caused by an infection with Staphylococcus aureus in staphylococcal TSS (see this term) or Streptococcus pyogenes in streptococcal TSS (see this term).EpidemiologyThe worldwide prevalence is estimated at 1/30, 000.Clinical descriptionThe disease affects mainly young adult women with no previous medical conditions. However, non-menstrual TSS, which can also be observed in men and children, represents up to 50% of Staphylococcal TSS cases. Onset is sudden and includes high fever (>38.9?C), nausea, diarrhea, vomiting, myalgia, abdominal pain and sore throat. Staphylococcal TSS almost always exhibits an erythematous rash and skin peeling as one of its manifestations, whereas it is very rarely seen in streptococcal TSS, which can show signs of soft tissue infection. Serious manifestations include confusion, shock, renal and myocardial dysfunction, acute respiratory distress syndrome (ARDS; see this term) and coma.EtiologyStaphylococcal TSS is due to an infection with Staphylococcus aureus and streptococcal TSS is due to an infection with Streptococcus pyogenes, or rarely, group C or G Streptococcus. Superantigens produced by both bacteria are responsible for the massive and sudden immune reaction seen in TSS. Both forms have been associated with recent traumas (surgery or childbirth) and viral infections, while staphylococcal TSS has also been associated with high absorbency tampon use.Visit the Orphanet disease page for more resources.

MalaCards based summary : Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and exanthem. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include monocytes, t cells and endothelial, and related phenotypes are hypotension and shock

Related Diseases for Staphylococcal Toxic Shock Syndrome

Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 398)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 31.3 TNF IL1B IFNG HMGB1 CIITA
2 exanthem 30.6 TNF IL1B IFNG
3 chronic ulcer of skin 30.3 TNF IL1B
4 streptococcus pneumonia 30.3 TNF IL1B
5 pharyngitis 30.3 TNF IL1B
6 chickenpox 30.2 TNF IFNG
7 allergic disease 30.1 TNF IL1B IFNG
8 osteomyelitis 29.9 TNF IL1B IFNG
9 bronchiolitis 29.9 TNF IL1B IFNG
10 aspergillosis 29.9 TNF IL1B IFNG
11 conjunctivitis 29.6 TNF IGHE IFNG
12 dermatitis, atopic 29.6 TNF IL1B IGHE IFNG
13 dermatitis 29.2 TNF IL1B IGHE IFNG
14 staphylococcal scarlet fever 11.6
15 infective endocarditis 10.2
16 endocarditis 10.2
17 acute kidney failure 10.2
18 lymphopenia 10.2
19 cytokine deficiency 10.2
20 physiological polycythemia 10.2 TNF IL1B
21 vulvar vestibulitis syndrome 10.2 TNF IL1B
22 palladium allergic contact dermatitis 10.2 TNF IL1B
23 kashin-beck disease 10.2 TNF IL1B
24 ulcer of lower limbs 10.2 TNF IL1B
25 arachnoiditis 10.2 TNF IL1B
26 cerebritis 10.2 TNF IL1B
27 actinic prurigo 10.2 TNF IL1B
28 stachybotrys chartarum 10.2 TNF IL1B
29 congenital cytomegalovirus 10.2 TNF IL1B
30 bacterial conjunctivitis 10.2 TNF IL1B
31 tracheitis 10.2 TNF IL1B
32 carbuncle 10.2 TNF IL1B
33 hypopyon 10.2 TNF IL1B
34 chemical colitis 10.2 TNF IL1B
35 tenosynovitis 10.2 TNF IL1B
36 aortitis 10.2 TNF IL1B
37 palindromic rheumatism 10.2 TNF IL1B
38 dental pulp necrosis 10.2 TNF IL1B
39 anthracosis 10.2 TNF IL1B
40 pneumonic tularemia 10.2 TNF IL1B
41 tularemia 10.2 TNF IL1B
42 peptic esophagitis 10.2 TNF IL1B
43 gingival recession 10.2 TNF IL1B
44 bursitis 10.2 TNF IL1B
45 laryngitis 10.2 TNF IL1B
46 haemophilus meningitis 10.2 TNF IL1B
47 vaginal discharge 10.2 TNF IL1B
48 irritant dermatitis 10.2 TNF IL1B
49 background diabetic retinopathy 10.2 TNF IL1B
50 iridocyclitis 10.2 TNF IL1B

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to Staphylococcal Toxic Shock Syndrome

Symptoms & Phenotypes for Staphylococcal Toxic Shock Syndrome

Human phenotypes related to Staphylococcal Toxic Shock Syndrome:

58 31 (show top 50) (show all 60)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypotension 58 31 hallmark (90%) Very frequent (99-80%) HP:0002615
2 shock 58 31 hallmark (90%) Very frequent (99-80%) HP:0031273
3 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
4 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
5 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
6 increased serum lactate 58 31 frequent (33%) Frequent (79-30%) HP:0002151
7 metabolic acidosis 58 31 frequent (33%) Frequent (79-30%) HP:0001942
8 tachycardia 58 31 frequent (33%) Frequent (79-30%) HP:0001649
9 respiratory distress 58 31 frequent (33%) Frequent (79-30%) HP:0002098
10 fasciitis 58 31 frequent (33%) Frequent (79-30%) HP:0100537
11 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
12 recurrent skin infections 58 31 frequent (33%) Frequent (79-30%) HP:0001581
13 abnormality of facial soft tissue 58 31 frequent (33%) Frequent (79-30%) HP:0011799
14 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
15 vomiting 58 31 occasional (7.5%) Occasional (29-5%) HP:0002013
16 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
17 sinusitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000246
18 hepatitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012115
19 thrombocytopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001873
20 elevated serum creatine kinase 58 31 occasional (7.5%) Occasional (29-5%) HP:0003236
21 cellulitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100658
22 hypocalcemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002901
23 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
24 skin rash 58 31 occasional (7.5%) Occasional (29-5%) HP:0000988
25 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
26 osteomyelitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002754
27 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
28 abnormality of the upper limb 58 31 occasional (7.5%) Occasional (29-5%) HP:0002817
29 hypoalbuminemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003073
30 abnormality of the lower limb 58 31 occasional (7.5%) Occasional (29-5%) HP:0002814
31 abnormal blistering of the skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0008066
32 tachypnea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002789
33 pneumonia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002090
34 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
35 myositis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100614
36 peritonitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002586
37 abscess 58 31 occasional (7.5%) Occasional (29-5%) HP:0025615
38 septic arthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0003095
39 disseminated intravascular coagulation 58 31 occasional (7.5%) Occasional (29-5%) HP:0005521
40 glomerulonephritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000099
41 localized skin lesion 58 31 occasional (7.5%) Occasional (29-5%) HP:0011355
42 scaling skin 58 31 occasional (7.5%) Occasional (29-5%) HP:0040189
43 elevated serum creatinine 58 31 occasional (7.5%) Occasional (29-5%) HP:0003259
44 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
45 capillary leak 58 31 occasional (7.5%) Occasional (29-5%) HP:0030005
46 chills 58 31 occasional (7.5%) Occasional (29-5%) HP:0025143
47 pharyngitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0025439
48 ecchymosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0031364
49 bacteremia 58 31 occasional (7.5%) Occasional (29-5%) HP:0031864
50 severe varicella zoster infection 58 31 occasional (7.5%) Occasional (29-5%) HP:0032170

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Search Clinical Trials , NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

40
Monocytes, T Cells, Endothelial

Publications for Staphylococcal Toxic Shock Syndrome

Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50) (show all 195)
# Title Authors PMID Year
1
An overlooked cause of septic shock: Staphylococcal Toxic Shock Syndrome secondary to an axillary abscess. 61
33473349 2021
2
Staphylococcal toxic shock syndrome in a child with interleukin-17 inhibitor treatment for psoriasis. 61
32533569 2020
3
Kawasaki Disease and COVID-19. 61
33196004 2020
4
IntegraⓇ dermal regeneration template as the nidus of staphylococcal toxic shock syndrome: A case report. 61
32613072 2020
5
Staphylococcal toxic shock syndrome in a lactating mother with breast abscess: A case report. 61
32760582 2020
6
A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec. 61
32872362 2020
7
Searching the staphylococcal toxic shock syndrome toxin -1 in septic children with negative cultures: A comparative study in Tehen,Iran. 61
32735530 2020
8
An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature. 61
31388911 2019
9
Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection. 61
31597722 2019
10
[Staphylococcal toxic shock syndrome should be considered in the event of diffuse erythema with fever and shock]. 61
30691878 2019
11
Molecular Typing and Variations in Amount of tst Gene Expression of TSST-1-Producing Clinical Staphylococcus aureus Isolates. 61
31275293 2019
12
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. 61
29350159 2018
13
[Intravenous immunoglobulin therapy in non-menstrual staphylococcal toxic shock syndrome]. 61
29050863 2018
14
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. 61
28721224 2017
15
Staphylococcus enterotoxin profile of China isolates and the superantigenicity of some novel enterotoxins. 61
28235987 2017
16
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. 61
28580155 2017
17
[Staphylococcal toxic shock syndrome at a chronic hemodialysis]. 61
28979632 2017
18
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. 61
27863161 2017
19
Fatal endocarditis with methicilin-sensible Staphylococcus aureus and major complications: rhabdomyolysis, pericarditis, and intracerebral hematoma: A case report and review of the literature. 61
27741135 2016
20
Acute encephalopathy with biphasic seizures and late reduced diffusion associated with staphylococcal toxic shock syndrome caused by burns. 61
27117386 2016
21
Safety, tolerability, and immunogenicity of a recombinant toxic shock syndrome toxin (rTSST)-1 variant vaccine: a randomised, double-blind, adjuvant-controlled, dose escalation first-in-man trial. 61
27296693 2016
22
Nosocomial Staphylococcal Toxic Shock. Case Report. 61
29967853 2016
23
Lactobacilli require physical contact to reduce staphylococcal TSST-1 secretion and vaginal epithelial inflammatory response. 61
27060097 2016
24
The Management of Staphylococcal Toxic Shock Syndrome. A Case Report. 61
29967843 2016
25
Staphylococcal Toxic Shock Syndrome Caused by an Intravaginal Product. A Case Report. 61
29967837 2016
26
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. 61
26543563 2015
27
Staphylococcal Purpura Fulminans: Report of a Case. 61
25099358 2015
28
A fatal case of staphylococcal toxic shock syndrome. 61
26265799 2015
29
Evidence of staphylococcal toxic shock syndrome caused by MRSA in a mother-newborn pair. 61
25260039 2015
30
Neutralization of staphylococcal enterotoxin B by an aptamer antagonist. 61
25624325 2015
31
[Severe burns related to steam inhalation therapy]. 61
24768268 2015
32
Staphylococcal toxic shock syndrome caused by tampon use. 61
25692047 2015
33
[Staphylococcal toxic shock syndrome after breast surgery]. 61
24636869 2014
34
Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. 61
24816557 2014
35
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. 61
24423010 2014
36
The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia. 61
25024509 2014
37
Vaccination with plasmid DNA encoding a mutant toxic shock syndrome toxin-1 ameliorates toxin-induced lethal shock in mice. 61
23985881 2013
38
Images in clinical medicine. Staphylococcal toxic shock syndrome. 61
23984732 2013
39
Clinical features and etiology of adult patients with Fever and rash. 61
23197907 2012
40
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. 61
22431984 2012
41
Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30. 61
22919639 2012
42
[Staphylococcal toxic shock syndrome in a 5 year-old child]. 61
21470720 2011
43
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. 61
21860665 2011
44
Toxigenic status of Staphylococcus aureus isolated from bovine raw milk and Minas frescal cheese in Brazil. 61
21219740 2010
45
Staphylococcal toxic shock syndrome: mechanisms and management. 61
21308522 2010
46
Toxic shock syndrome toxin-1 (TSST-1) antibody levels in Japanese children. 61
20036064 2010
47
TLR2 signalling: At the crossroads of commensalism, invasive infections and toxic shock syndrome by Staphylococcus aureus. 61
20363358 2010
48
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. 61
21253349 2010
49
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. 61
20367234 2010
50
Staphylococcus aureus exotoxins are present in vivo in tampons. 61
20335433 2010

Variations for Staphylococcal Toxic Shock Syndrome

Expression for Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for Staphylococcal Toxic Shock Syndrome

Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 TNF IL1B IGHE IFNG HMGB1 CIITA
2
Show member pathways
13.09 TNF IL1B IGHE IFNG CIITA
3
Show member pathways
12.98 TNF IL1B IFNG HMGB1
4
Show member pathways
12.65 TNF IL1B IFNG CIITA
5
Show member pathways
12.62 TNF IL1B IFNG CIITA
6
Show member pathways
12.47 TNF IL1B IFNG
7
Show member pathways
12.41 TNF IL1B IFNG
8
Show member pathways
12.4 TNF IL1B IFNG
9
Show member pathways
12.39 TNF IL1B IFNG
10
Show member pathways
12.35 TNF IFNG HMGB1
11 12.34 TNF IL1B IFNG CIITA
12
Show member pathways
12.16 TNF IL1B IFNG
13
Show member pathways
12.16 TNF IL1B IFNG
14
Show member pathways
12.13 TNF IL1B IFNG
15
Show member pathways
12.07 TNF IL1B IFNG
16
Show member pathways
12.02 TNF IL1B IFNG
17 11.94 TNF IL1B IFNG
18 11.9 TNF IL1B IFNG
19
Show member pathways
11.9 TNF IL1B IFNG CIITA
20 11.85 TNF IL1B IFNG
21 11.82 TNF IL1B IGHE
22 11.76 TNF IL1B IFNG
23 11.71 TNF IL1B IFNG
24 11.71 TNF IL1B IFNG CIITA
25
Show member pathways
11.69 IL1B IFNG
26 11.64 TNF IL1B IFNG
27
Show member pathways
11.6 TNF IL1B IFNG
28 11.58 TNF IL1B IFNG
29
Show member pathways
11.49 TNF IL1B IFNG
30 11.41 TNF IFNG
31
Show member pathways
11.41 TNF IFNG
32 11.39 TNF IL1B
33 11.38 TNF HMGB1
34 11.37 TNF IL1B IFNG
35 11.33 TNF IL1B IFNG
36
Show member pathways
11.31 TNF IL1B
37 11.31 TNF IL1B IFNG
38 11.26 TNF IL1B IFNG
39
Show member pathways
11.23 TNF IFNG
40 11.21 TNF IL1B
41 11.15 TNF IL1B
42 11.15 IL1B IFNG CIITA
43
Show member pathways
11.15 TNF IL1B IFNG HMGB1
44 11.11 TNF IL1B IFNG
45 11.05 IL1B IFNG
46 10.98 TNF IL1B
47 10.94 TNF IL1B IFNG
48 10.84 TNF IL1B
49 10.59 TNF IL1B IFNG

GO Terms for Staphylococcal Toxic Shock Syndrome

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 TNF IL1B IGHE IFNG HMGB1

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.97 TNF IFNG HMGB1 CIITA
2 inflammatory response GO:0006954 9.87 TNF IL1B HMGB1 CIITA
3 cytokine-mediated signaling pathway GO:0019221 9.86 TNF IL1B IGHE
4 cellular response to lipopolysaccharide GO:0071222 9.81 TNF IL1B HMGB1
5 positive regulation of inflammatory response GO:0050729 9.75 TNF IL1B IFNG
6 positive regulation of JNK cascade GO:0046330 9.73 TNF IL1B HMGB1
7 regulation of insulin secretion GO:0050796 9.71 TNF IL1B IFNG
8 positive regulation of protein complex assembly GO:0031334 9.7 TNF IFNG
9 positive regulation of cytokine production GO:0001819 9.7 TNF IFNG
10 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.7 TNF HMGB1
11 negative regulation of blood vessel endothelial cell migration GO:0043537 9.7 TNF HMGB1
12 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF IFNG
13 positive regulation of interleukin-12 production GO:0032735 9.69 IFNG HMGB1
14 protein kinase B signaling GO:0043491 9.69 TNF IL1B
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 TNF IL1B HMGB1
16 positive regulation of chemokine production GO:0032722 9.68 TNF IFNG
17 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 TNF IL1B
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.68 TNF IL1B
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 TNF IL1B
20 microglial cell activation GO:0001774 9.67 TNF IFNG
21 positive regulation of interleukin-8 production GO:0032757 9.67 TNF IL1B HMGB1
22 negative regulation of neurogenesis GO:0050768 9.66 TNF IL1B
23 positive regulation of osteoclast differentiation GO:0045672 9.66 TNF IFNG
24 positive regulation of amyloid-beta formation GO:1902004 9.65 TNF IFNG
25 positive regulation of glial cell proliferation GO:0060252 9.65 TNF IL1B
26 negative regulation of lipid catabolic process GO:0050995 9.65 TNF IL1B
27 positive regulation of interleukin-1 beta production GO:0032731 9.65 TNF IFNG HMGB1
28 immune response GO:0006955 9.65 TNF IL1B IGHE IFNG CIITA
29 astrocyte activation GO:0048143 9.64 TNF IFNG
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 TNF IL1B
31 macrophage activation involved in immune response GO:0002281 9.63 IFNG HMGB1
32 positive regulation of phagocytosis GO:0050766 9.63 TNF IL1B IFNG
33 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.62 IL1B HMGB1
34 positive regulation of neuroinflammatory response GO:0150078 9.62 TNF IL1B
35 positive regulation of protein phosphorylation GO:0001934 9.62 TNF IL1B IFNG HMGB1
36 negative regulation of amyloid-beta clearance GO:1900222 9.61 TNF IFNG
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IFNG CIITA
38 positive regulation of nitric oxide biosynthetic process GO:0045429 9.61 TNF IL1B IFNG
39 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.6 TNF HMGB1
40 regulation of establishment of endothelial barrier GO:1903140 9.59 TNF IL1B
41 vascular endothelial growth factor production GO:0010573 9.58 TNF IL1B
42 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
43 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
44 positive regulation of vitamin D biosynthetic process GO:0060557 9.4 TNF IFNG
45 positive regulation of nitrogen compound metabolic process GO:0051173 9.37 TNF IFNG
46 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.33 TNF IL1B IFNG
47 positive regulation of interleukin-6 production GO:0032755 9.26 TNF IL1B IFNG HMGB1
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.13 TNF HMGB1 CIITA
2 cytokine activity GO:0005125 8.92 TNF IL1B IFNG HMGB1

Sources for Staphylococcal Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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