MCID: STP004
MIFTS: 41

Staphylococcal Toxic Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Staphylococcal Toxic Shock Syndrome

MalaCards integrated aliases for Staphylococcal Toxic Shock Syndrome:

Name: Staphylococcal Toxic Shock Syndrome 52 71
Bacterial Toxic-Shock Syndrome 52 58
Staphylococcal Toxic-Shock Syndrome 58
Staphylococcal Tss 58
Bacterial Tss 58

Characteristics:

Orphanet epidemiological data:

58
bacterial toxic-shock syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
staphylococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A48.3
UMLS via Orphanet 72 C3714602
UMLS 71 C3714602

Summaries for Staphylococcal Toxic Shock Syndrome

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 36234 Definition Bacterial toxic shock syndrome (TSS) is a potentially fatal, acute disease characterized by a sudden onset of high fever along with nausea, myalgia, vomiting and multisystem organ involvement, potentially leading to shock and death. TSS is mediated by superantigenic toxins , usually caused by an infection with Staphylococcus aureus in staphylococcal TSS (see this term) or Streptococcus pyogenes in streptococcal TSS (see this term). Epidemiology The worldwide prevalence is estimated at 1/30, 000. Clinical description The disease affects mainly young adult women with no previous medical conditions. However, non-menstrual TSS, which can also be observed in men and children, represents up to 50% of Staphylococcal TSS cases. Onset is sudden and includes high fever (>38.9?C), nausea, diarrhea, vomiting, myalgia, abdominal pain and sore throat. Staphylococcal TSS almost always exhibits an erythematous rash and skin peeling as one of its manifestations, whereas it is very rarely seen in streptococcal TSS, which can show signs of soft tissue infection. Serious manifestations include confusion, shock, renal and myocardial dysfunction, acute respiratory distress syndrome (ARDS; see this term) and coma. Etiology Staphylococcal TSS is due to an infection with Staphylococcus aureus and streptococcal TSS is due to an infection with Streptococcus pyogenes , or rarely, group C or G Streptococcus. Superantigens produced by both bacteria are responsible for the massive and sudden immune reaction seen in TSS. Both forms have been associated with recent traumas (surgery or childbirth) and viral infections, while staphylococcal TSS has also been associated with high absorbency tampon use. Visit the Orphanet disease page for more resources.

MalaCards based summary : Staphylococcal Toxic Shock Syndrome, also known as bacterial toxic-shock syndrome, is related to toxic shock syndrome and pharyngitis. An important gene associated with Staphylococcal Toxic Shock Syndrome is TNF (Tumor Necrosis Factor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Amoxicillin and Clavulanate have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and monocytes.

Related Diseases for Staphylococcal Toxic Shock Syndrome

Diseases related to Staphylococcal Toxic Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 31.5 TNF IL1B IFNG HMGB1 CIITA
2 pharyngitis 30.2 TNF IL1B
3 chickenpox 30.1 TNF IFNG
4 diarrhea 29.8 TNF IL1B IFNG
5 osteomyelitis 29.6 TNF IL1B IFNG
6 aspergillosis 29.6 TNF IL1B IFNG
7 immune deficiency disease 29.6 TNF IFNG CIITA
8 allergic hypersensitivity disease 29.4 TNF IGHE IFNG
9 autoimmune disease 29.1 TNF IL1B IFNG CIITA
10 dermatitis, atopic 29.0 TNF IL1B IGHE IFNG
11 staphylococcal scarlet fever 12.0
12 exanthem 10.4
13 stromal keratitis 10.3 TNF CIITA
14 systemic onset juvenile idiopathic arthritis 10.2 TNF IL1B
15 vulvar vestibulitis syndrome 10.2 TNF IL1B
16 palladium allergic contact dermatitis 10.2 TNF IL1B
17 kashin-beck disease 10.2 TNF IL1B
18 congenital cytomegalovirus 10.2 TNF IL1B
19 actinic prurigo 10.2 TNF IL1B
20 macrophage activation syndrome 10.2 TNF HMGB1
21 stachybotrys chartarum 10.2 TNF IL1B
22 palindromic rheumatism 10.2 TNF IL1B
23 irritant dermatitis 10.2 TNF IL1B
24 autoimmune vasculitis 10.2 TNF IL1B
25 periapical periodontitis 10.2 TNF IL1B
26 dental pulp disease 10.2 TNF IL1B
27 laryngitis 10.2 TNF IL1B
28 bagassosis 10.2 TNF IL1B
29 glossitis 10.2 TNF IL1B
30 polyradiculopathy 10.2 TNF IL1B
31 subacute thyroiditis 10.2 TNF IL1B
32 opisthorchiasis 10.2 TNF IL1B
33 burning mouth syndrome 10.2 TNF IL1B
34 poems syndrome 10.2 TNF IL1B
35 chronic recurrent multifocal osteomyelitis 10.2 TNF IL1B
36 cerebral artery occlusion 10.2 TNF IL1B
37 endophthalmitis 10.2 TNF HMGB1
38 drug-induced lupus erythematosus 10.2 TNF IL1B
39 endometrial disease 10.2 TNF IL1B
40 vaginitis 10.2 TNF IL1B
41 pulpitis 10.2 TNF IL1B
42 bone deterioration disease 10.2 TNF IL1B
43 lacrimal apparatus disease 10.2 TNF IL1B
44 gingival disease 10.2 TNF IL1B
45 perinatal necrotizing enterocolitis 10.2 TNF IL1B
46 autoimmune myocarditis 10.2 TNF IFNG
47 spotted fever 10.1 TNF IFNG
48 spotted fever rickettsiosis 10.1 TNF IFNG
49 vaginal disease 10.1 TNF IL1B
50 adult-onset still's disease 10.1 TNF IL1B

Graphical network of the top 20 diseases related to Staphylococcal Toxic Shock Syndrome:



Diseases related to Staphylococcal Toxic Shock Syndrome

Symptoms & Phenotypes for Staphylococcal Toxic Shock Syndrome

Drugs & Therapeutics for Staphylococcal Toxic Shock Syndrome

Drugs for Staphylococcal Toxic Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
3
Rifampicin Approved Phase 4 13292-46-1 5381226 5458213
4
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
5
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
6 Immunologic Factors Phase 4
7 Antibiotics, Antitubercular Phase 4
8 Clindamycin palmitate Phase 4
9 Amoxicillin-Potassium Clavulanate Combination Phase 4
10 Rho(D) Immune Globulin Phase 4
11 Clindamycin phosphate Phase 4
12 Pharmaceutical Solutions Phase 4
13 gamma-Globulins Phase 4
14 Antibodies Phase 4
15 beta-Lactamase Inhibitors Phase 4
16 Immunoglobulins Phase 4
17 Anti-Bacterial Agents Phase 4
18 Anti-Infective Agents Phase 4
19 Immunoglobulins, Intravenous Phase 4
20
Proline Nutraceutical Phase 4 147-85-3 145742

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effectiveness of Intravenous Immunoglobulins (IVIG) in Toxic Shock Syndromes in Children: a Multicentre European Randomized Controlled Trial Not yet recruiting NCT02899702 Phase 4 PRIVIGEN (CSL Behring);Albumin

Search NIH Clinical Center for Staphylococcal Toxic Shock Syndrome

Genetic Tests for Staphylococcal Toxic Shock Syndrome

Anatomical Context for Staphylococcal Toxic Shock Syndrome

MalaCards organs/tissues related to Staphylococcal Toxic Shock Syndrome:

40
Skin, T Cells, Monocytes, Breast, B Cells, Bone, Testes

Publications for Staphylococcal Toxic Shock Syndrome

Articles related to Staphylococcal Toxic Shock Syndrome:

(show top 50) (show all 189)
# Title Authors PMID Year
1
An Elusive Case of Mycosis Fungoides: Case Report and Review of the Literature. 61
31388911 2019
2
Toxic Shock Syndrome Toxin 1 Evaluation and Antibiotic Impact in a Transgenic Model of Staphylococcal Soft Tissue Infection. 61
31597722 2019
3
[Staphylococcal toxic shock syndrome should be considered in the event of diffuse erythema with fever and shock]. 61
30691878 2019
4
Molecular Typing and Variations in Amount of tst Gene Expression of TSST-1-Producing Clinical Staphylococcus aureus Isolates. 61
31275293 2019
5
[Intravenous immunoglobulin therapy in non-menstrual staphylococcal toxic shock syndrome]. 61
29050863 2018
6
Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom. 61
29350159 2018
7
Erratum: Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. 61
28721224 2017
8
Staphylococcus enterotoxin profile of China isolates and the superantigenicity of some novel enterotoxins. 61
28235987 2017
9
Intense, flu-like symptoms in women using menstrual devices: always think of staphylococcal Toxic Shock Syndrome. 61
28580155 2017
10
[Staphylococcal toxic shock syndrome at a chronic hemodialysis]. 61
28979632 2017
11
HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model. 61
27863161 2017
12
Fatal endocarditis with methicilin-sensible Staphylococcus aureus and major complications: rhabdomyolysis, pericarditis, and intracerebral hematoma: A case report and review of the literature. 61
27741135 2016
13
Acute encephalopathy with biphasic seizures and late reduced diffusion associated with staphylococcal toxic shock syndrome caused by burns. 61
27117386 2016
14
Safety, tolerability, and immunogenicity of a recombinant toxic shock syndrome toxin (rTSST)-1 variant vaccine: a randomised, double-blind, adjuvant-controlled, dose escalation first-in-man trial. 61
27296693 2016
15
Nosocomial Staphylococcal Toxic Shock. Case Report. 61
29967853 2016
16
Lactobacilli require physical contact to reduce staphylococcal TSST-1 secretion and vaginal epithelial inflammatory response. 61
27060097 2016
17
The Management of Staphylococcal Toxic Shock Syndrome. A Case Report. 61
29967843 2016
18
Staphylococcal Toxic Shock Syndrome Caused by an Intravaginal Product. A Case Report. 61
29967837 2016
19
Unusual staphylococcal toxic shock syndrome presenting as a scarlet-like fever. 61
26543563 2015
20
Staphylococcal Purpura Fulminans: Report of a Case. 61
25099358 2015
21
A fatal case of staphylococcal toxic shock syndrome. 61
26265799 2015
22
Evidence of staphylococcal toxic shock syndrome caused by MRSA in a mother-newborn pair. 61
25260039 2015
23
Neutralization of staphylococcal enterotoxin B by an aptamer antagonist. 61
25624325 2015
24
[Severe burns related to steam inhalation therapy]. 61
24768268 2015
25
Staphylococcal toxic shock syndrome caused by tampon use. 61
25692047 2015
26
[Staphylococcal toxic shock syndrome after breast surgery]. 61
24636869 2014
27
Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression. 61
24816557 2014
28
The impact of Staphylococcus aureus-associated molecular patterns on staphylococcal superantigen-induced toxic shock syndrome and pneumonia. 61
25024509 2014
29
Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. 61
24423010 2014
30
Vaccination with plasmid DNA encoding a mutant toxic shock syndrome toxin-1 ameliorates toxin-induced lethal shock in mice. 61
23985881 2013
31
Images in clinical medicine. Staphylococcal toxic shock syndrome. 61
23984732 2013
32
Clinical features and etiology of adult patients with Fever and rash. 61
23197907 2012
33
Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1. 61
22431984 2012
34
Evolutionary blueprint for host- and niche-adaptation in Staphylococcus aureus clonal complex CC30. 61
22919639 2012
35
[Staphylococcal toxic shock syndrome in a 5 year-old child]. 61
21470720 2011
36
Staphylococcal toxic shock syndrome 2000-2006: epidemiology, clinical features, and molecular characteristics. 61
21860665 2011
37
Toxigenic status of Staphylococcus aureus isolated from bovine raw milk and Minas frescal cheese in Brazil. 61
21219740 2010
38
Staphylococcal toxic shock syndrome: mechanisms and management. 61
21308522 2010
39
Toxic shock syndrome toxin-1 (TSST-1) antibody levels in Japanese children. 61
20036064 2010
40
Use of recombinant human activated protein C in nonmenstrual staphylococcal toxic shock syndrome. 61
21253349 2010
41
TLR2 signalling: At the crossroads of commensalism, invasive infections and toxic shock syndrome by Staphylococcus aureus. 61
20363358 2010
42
Staphylococcal toxic shock syndrome, superantigenicity, and hypersensitivity. 61
20367234 2010
43
Staphylococcus aureus exotoxins are present in vivo in tampons. 61
20335433 2010
44
Staphylococcal toxic shock syndrome presenting as acute respiratory distress and cor pulmonale. 61
20196940 2010
45
Staphylococcal toxic shock syndrome erythroderma is associated with superantigenicity and hypersensitivity. 61
19911998 2009
46
Evaluation of surveillance methods for staphylococcal toxic shock syndrome. 61
19402965 2009
47
Biological characterization of the zinc site coordinating histidine residues of staphylococcal enterotoxin C2. 61
19246739 2009
48
Tigecycline attenuates staphylococcal superantigen-induced T-cell proliferation and production of cytokines and chemokines. 61
19874226 2009
49
Analysis of the early response to TSST-1 reveals Vbeta-unrestricted extravasation, compartmentalization of the response, and unresponsiveness but not anergy to TSST-1. 61
18923105 2009
50
[Production and characterization of anti-staphylococcal toxic shock syndrome toxin-1 monoclonal antibody]. 61
19127110 2008

Variations for Staphylococcal Toxic Shock Syndrome

Expression for Staphylococcal Toxic Shock Syndrome

Search GEO for disease gene expression data for Staphylococcal Toxic Shock Syndrome.

Pathways for Staphylococcal Toxic Shock Syndrome

Pathways related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 TNF IL1B IGHE IFNG HMGB1 CIITA
2
Show member pathways
13.11 TNF IL1B IGHE IFNG CIITA
3
Show member pathways
12.99 TNF IL1B IFNG HMGB1
4
Show member pathways
12.66 TNF IL1B IFNG CIITA
5
Show member pathways
12.62 TNF IL1B IFNG CIITA
6
Show member pathways
12.56 TNF IL1B IFNG HMGB1
7
Show member pathways
12.47 TNF IL1B IFNG
8
Show member pathways
12.45 TNF IGHE IFNG
9
Show member pathways
12.41 TNF IL1B IFNG
10
Show member pathways
12.4 TNF IL1B IFNG
11
Show member pathways
12.39 TNF IL1B IFNG
12 12.35 TNF IL1B IFNG CIITA
13
Show member pathways
12.17 TNF IL1B IFNG
14
Show member pathways
12.16 TNF IL1B IFNG
15
Show member pathways
12.14 TNF IL1B IFNG
16
Show member pathways
12.07 TNF IL1B IFNG
17
Show member pathways
12.04 TNF IL1B IFNG
18 11.96 TNF IL1B IFNG
19
Show member pathways
11.95 TNF IL1B IFNG CIITA
20
Show member pathways
11.92 TNF IL1B IFNG
21 11.91 TNF IL1B IFNG
22 11.87 TNF IL1B IFNG
23 11.83 TNF IL1B IGHE
24 11.81 TNF IL1B IFNG CIITA
25 11.77 TNF IL1B IFNG
26 11.72 TNF IL1B IFNG
27
Show member pathways
11.69 IL1B IFNG
28
Show member pathways
11.69 TNF IL1B IFNG HMGB1
29 11.65 TNF IL1B IFNG
30 11.6 TNF IL1B IFNG
31 11.57 TNF IL1B IFNG
32
Show member pathways
11.5 TNF IL1B IFNG
33 11.48 TNF IFNG
34 11.47 TNF IL1B
35 11.41 TNF IFNG
36
Show member pathways
11.4 TNF IFNG
37 11.39 TNF IL1B
38 11.39 TNF IL1B IFNG
39 11.38 TNF HMGB1
40 11.35 TNF IL1B IFNG
41 11.33 TNF IL1B IFNG
42
Show member pathways
11.32 TNF IL1B
43 11.29 TNF IL1B IFNG
44 11.22 TNF IL1B
45 11.18 IL1B IFNG CIITA
46 11.16 TNF IL1B
47 11.15 TNF IL1B IFNG
48 11.06 IL1B IFNG
49
Show member pathways
11.02 TNF IL1B IFNG HMGB1
50 11 TNF IL1B IFNG

GO Terms for Staphylococcal Toxic Shock Syndrome

Cellular components related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 TNF IL1B IGHE IFNG HMGB1

Biological processes related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 TNF IL1B HMGB1 CIITA
2 negative regulation of transcription by RNA polymerase II GO:0000122 9.96 TNF IFNG HMGB1 CIITA
3 inflammatory response GO:0006954 9.87 TNF IL1B HMGB1 CIITA
4 cytokine-mediated signaling pathway GO:0019221 9.85 TNF IL1B IGHE
5 positive regulation of protein phosphorylation GO:0001934 9.81 TNF IL1B IFNG
6 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL1B HMGB1
7 positive regulation of JNK cascade GO:0046330 9.73 TNF IL1B HMGB1
8 immune response GO:0006955 9.72 TNF IL1B IGHE IFNG CIITA
9 regulation of insulin secretion GO:0050796 9.71 TNF IL1B IFNG
10 humoral immune response GO:0006959 9.7 TNF IFNG
11 positive regulation of protein localization to plasma membrane GO:1903078 9.7 TNF IFNG
12 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.7 TNF HMGB1
13 positive regulation of autophagy GO:0010508 9.69 IFNG HMGB1
14 extrinsic apoptotic signaling pathway GO:0097191 9.69 TNF IFNG
15 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 TNF IL1B HMGB1
16 positive regulation of interferon-gamma production GO:0032729 9.68 TNF IL1B
17 positive regulation of protein complex assembly GO:0031334 9.68 TNF IFNG
18 protein kinase B signaling GO:0043491 9.68 TNF IL1B
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 TNF IL1B
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF IL1B
21 microglial cell activation GO:0001774 9.67 TNF IFNG
22 positive regulation of interleukin-6 production GO:0032755 9.67 TNF IL1B HMGB1
23 negative regulation of neurogenesis GO:0050768 9.66 TNF IL1B
24 positive regulation of interleukin-8 production GO:0032757 9.66 TNF IL1B
25 positive regulation of interleukin-12 production GO:0032735 9.65 IFNG HMGB1
26 positive regulation of osteoclast differentiation GO:0045672 9.65 TNF IFNG
27 positive regulation of phagocytosis GO:0050766 9.65 TNF IL1B IFNG
28 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 TNF IL1B
29 positive regulation of glial cell proliferation GO:0060252 9.64 TNF IL1B
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 TNF IL1B IFNG
31 positive regulation of amyloid-beta formation GO:1902004 9.62 TNF IFNG
32 negative regulation of lipid catabolic process GO:0050995 9.62 TNF IL1B
33 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B
34 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TNF IL1B
35 positive regulation of neuroinflammatory response GO:0150078 9.6 TNF IL1B
36 negative regulation of amyloid-beta clearance GO:1900222 9.59 TNF IFNG
37 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IFNG CIITA
38 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
39 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
40 positive regulation of interleukin-6 secretion GO:2000778 9.54 TNF IL1B HMGB1
41 sequestering of triglyceride GO:0030730 9.52 TNF IL1B
42 positive regulation of vitamin D biosynthetic process GO:0060557 9.43 TNF IFNG
43 astrocyte activation GO:0048143 9.43 TNF IL1B IFNG
44 positive regulation of nitrogen compound metabolic process GO:0051173 9.4 TNF IFNG
45 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.33 TNF IL1B IFNG
46 positive regulation of chemokine biosynthetic process GO:0045080 9.13 TNF IL1B IFNG
47 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 TNF IL1B IFNG

Molecular functions related to Staphylococcal Toxic Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.13 TNF HMGB1 CIITA
2 cytokine activity GO:0005125 8.92 TNF IL1B IFNG HMGB1

Sources for Staphylococcal Toxic Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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