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MCID: STT002
MIFTS: 49

Status Asthmaticus

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Status Asthmaticus

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MalaCards integrated aliases for Status Asthmaticus:

Name: Status Asthmaticus 12 54 44 15 17 71 32
Asthma with Status Asthmaticus 12
Severe Asthma Attack 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9362
ICD9CM 34 493.91
MeSH 44 D013224
NCIt 50 C122577
SNOMED-CT 67 36979006
ICD10 32 J46
UMLS 71 C0038218
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Summaries for Status Asthmaticus

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Disease Ontology : 12 An acute asthma that is characterized by an acute episode with a progressive severity that is poorly responsive to standard therapeutic measures, regardless of disease severity or phenotypic variant.

MalaCards based summary : Status Asthmaticus, also known as asthma with status asthmaticus, is related to acute asthma and allergic asthma. An important gene associated with Status Asthmaticus is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone acetate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, medulla oblongata and trachea, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not... more...

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Related Diseases for Status Asthmaticus

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Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 374)
# Related Disease Score Top Affiliating Genes
1 acute asthma 31.4 RNASE3 IL5 ADRB2
2 allergic asthma 31.3 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
3 chronic asthma 30.9 RNASE3 IL5 CCL11
4 near-fatal asthma 30.8 CCL5 ADRB2
5 ige responsiveness, atopic 30.3 RNASE3 IL5 IL10
6 bacterial pneumonia 30.2 IL10 ELANE CXCL8
7 enterocolitis 30.1 IL10 CXCL8
8 bronchopneumonia 30.0 IL10 ELANE CXCL8
9 pulmonary emphysema 29.9 MMP9 ELANE CXCL8
10 duodenal ulcer 29.8 IL1RN IL10 CXCL8
11 alpha-1-antitrypsin deficiency 29.8 MMP3 ELANE CXCL8
12 pertussis 29.7 IL10 CXCL8 CCL5 CCL11
13 esophagitis 29.6 RNASE3 IL5 IL10 CXCL8 CCL11
14 hypereosinophilic syndrome 29.5 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
15 allergic rhinitis 29.5 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
16 pre-eclampsia 29.5 MMP9 IL10 CXCL8 ADRB2
17 otitis media 29.4 RNASE3 MUC5AC IL5 IL10 CXCL8 CCL11
18 dermatitis 29.4 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
19 neutropenia 29.3 IL1RN IL10 ELANE CXCL8
20 adult respiratory distress syndrome 29.3 IL1RN IL1R1 IL10 ELANE CXCL8 ADRB2
21 gastritis 29.3 IL1RN IL10 CXCL8 CCL5
22 bronchitis 29.2 RNASE3 MMP9 IL5 IL10 ELANE CXCL8
23 rhinitis 29.2 RNASE3 IL5 IL10 CXCL8 CCL7 CCL5
24 thrombocytopenia 28.9 PIK3C2A MMP9 IL1RN IL10 CXCL8
25 asthma 28.8 RNASE3 MUC5AC MMP9 IL5 IL1RN IL1R1
26 respiratory failure 28.8 RNASE3 PIK3C2A MUC5AC IL5 IL1RN IL1R1
27 lung disease 28.4 RNASE3 MUC5AC MMP9 IL5 IL10 ELANE
28 proteasome-associated autoinflammatory syndrome 1 27.7 RNASE3 MMP9 IL5 IL1RN IL1R1 IL10
29 myopathy 10.6
30 pneumothorax 10.5
31 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.4
32 pemphigoid 10.4 IL5 CCL11
33 metabolic acidosis 10.4
34 loeffler endocarditis 10.4 RNASE3 IL5
35 perinephritis 10.3 PIK3C2A ADRB2
36 cough variant asthma 10.3 RNASE3 IL5
37 eosinophilic gastritis 10.3 IL5 CCL11
38 respiratory syncytial virus infectious disease 10.3 IL5 CCL5
39 disseminated eosinophilic collagen disease 10.3 RNASE3 IL5
40 kimura disease 10.3 RNASE3 IL5
41 adhesive otitis media 10.3 RNASE3 CCL11
42 ceftriaxone allergy 10.3 IL5 IL10
43 vernal conjunctivitis 10.3 RNASE3 MUC5AC
44 lung mucoepidermoid carcinoma 10.3 MUC5AC CXCL8
45 eustachian tube disease 10.3 RNASE3 CCL11
46 cow milk allergy 10.3 IL5 IL10
47 myoglobinuria 10.3
48 quadriplegia 10.3
49 lactic acidosis 10.3
50 mikulicz disease 10.3 IL5 IL10

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 13)


Anxiety Asthma
Bronchitis Chronic Maxillary Sinusitis
Chronic Pulmonary Heart Disease Conn's Syndrome
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Oral Candidiasis Osteoporosis
Respiratory Failure

Graphical network of the top 20 diseases related to Status Asthmaticus:



Diseases related to Status Asthmaticus
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Symptoms & Phenotypes for Status Asthmaticus

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MGI Mouse Phenotypes related to Status Asthmaticus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ADRB2 CCL11 CCL5 ELANE IL10 IL1R1
2 immune system MP:0005387 9.4 ADRB2 CCL11 CCL5 ELANE IL10 IL1R1
Sources

Drugs & Therapeutics for Status Asthmaticus

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Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
9
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 Bronchodilator Agents Phase 4
11 Formoterol Fumarate Phase 4
12
Beclomethasone Phase 4 4419-39-0 20469
13 Sympathomimetics Phase 4
14 Respiratory System Agents Phase 4
15 Anti-Asthmatic Agents Phase 4
16 Albuterol Phase 4
17 Adrenergic beta-Agonists Phase 4
18 Adrenergic Agents Phase 4
19 Neurotransmitter Agents Phase 4
20 Tocolytic Agents Phase 4
21 Adrenergic Agonists Phase 4
22 Pharmaceutical Solutions Phase 4
23 Hormone Antagonists Phase 4
24 Hormones Phase 4
25 Gastrointestinal Agents Phase 4
26 Anti-Inflammatory Agents Phase 4
27 Methylprednisolone Acetate Phase 4
28 glucocorticoids Phase 4
29 Antiemetics Phase 4
30 Antineoplastic Agents, Hormonal Phase 4
31 BB 1101 Phase 4
32
Montelukast Approved Phase 2, Phase 3 158966-92-8 5281040
33
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
34 Leukotriene Antagonists Phase 2, Phase 3
35 Anesthetics Phase 3
36 Analgesics Phase 3
37 Excitatory Amino Acid Antagonists Phase 3
38 Anesthetics, Dissociative Phase 3
39 Anesthetics, Intravenous Phase 3
40 Anesthetics, General Phase 3
41 Benralizumab Approved, Investigational Phase 2 1044511-01-4
42 Immunoglobulins Phase 2
43 Antibodies Phase 2
44 Antibodies, Monoclonal Phase 2
45
Budesonide Approved Phase 1 51333-22-3 63006 5281004
46
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
47
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
48 Protective Agents Phase 1
49 Neuroprotective Agents Phase 1
50 Cholinergic Antagonists Phase 1

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Extra-fine Formoterol/Beclomethasone in the Treatment of Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
2 Efficacy of a Loading Dose of IV Salbutamol in Children Admitted to a PICU for Severe Acute Asthma or Severe Acute Wheeze Completed NCT03493503 Phase 4 Salbutamol;Sodium Chloride 0.9%
3 Double-blinded Randomized Trial of Terbutaline to Shorten ICU Length of Stay in the Treatment of Status Asthmaticus in Children Completed NCT00124995 Phase 4 terbutaline
4 Continuous Levalbuterol for Treatment of Status Asthmaticus in Children Completed NCT00124176 Phase 4 Racemic albuterol (R+S albuterol);Levalbuterol (R albuterol)
5 Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit Enrolling by invitation NCT03900624 Phase 4 Dexamethasone
6 Comparison of Benzalkonium Chloride Containing Albuterol Versus Preservative Free Albuterol for the Treatment of Status Asthmaticus Suspended NCT02966184 Phase 4 preservative free albuterol
7 Oral Dexamethasone Versus Oral Prednisone in Children Hospitalized With Asthma: A Randomized Control Study Terminated NCT02780479 Phase 4 Dexamethasone;Prednisone
8 Pharmacokinetics and Pharmacodynamics of Montelukast in Children, Ages 6 Through 18 Years Old, With Status Asthmaticus Unresponsive to Conventional Treatment Unknown status NCT00494572 Phase 2, Phase 3 Montelukast
9 Montelukast With Status Asthmaticus, Ages 2-5 Unknown status NCT00491790 Phase 2, Phase 3 Montelukast
10 The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room Completed NCT01524198 Phase 2, Phase 3 Budesonide;Normal saline
11 The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study Not yet recruiting NCT03338205 Phase 3 Ketamine
12 Randomized Double Blind Placebo Controlled Trial of Benralizumab, an Antiinterleukin 5 Receptor α Monoclonal Antibody, Initiated During Hospitalization for Severe Asthma Attack in Reducing Severe Exacerbations: Phase 2B Study Not yet recruiting NCT04617171 Phase 2 Benralizumab 30 MG/ML [Fasenra];Placebos
13 A Phase II, Randomized, Modified Single-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of MN-221 When Administered Intravenously as an Adjunct to Standard Therapy to Adults With an Acute Exacerbation of Asthma Terminated NCT00683449 Phase 2 Dose Group 1;MN-221 placebo;Dose Group 2;Dose Group 3
14 A Prospective, Randomized, Controlled, Single Center Trial of the Use of Heliox in Children Admitted to the Hospital With Status Asthmaticus Terminated NCT00410150 Phase 2 Helium-oxygen-driven albuterol nebulizer;Oxygen
15 Effect Of Early Initiation Of Noninvasive Positive Pressure Ventilation On ICU Length Of Stay In Children With Status Asthmaticus, A Prospective Randomized Trial Withdrawn NCT01403428 Phase 2
16 High Fidelity Simulation (HFS) Versus Video-case(VC) Trainings in the Assessement and Management of Severe Asthma Attack Among Medical School Students: a Randomized Controlled Study Completed NCT02776358 Phase 1
17 A Phase I, Single Center, Placebo-Controlled, Blinded Pilot Study of Ipratropium Bromide in Children Admitted to the Intensive Care Unit With Status Asthmaticus Completed NCT02872597 Phase 1 Ipratropium;0.9% Sodium Chloride;Albuterol;corticosteroids
18 Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Managed in the Emergency Department: A Randomized Controlled Trial Recruiting NCT04016220 Phase 1 Budesonide;normal saline
19 Safety and Efficacy of Early Initiation of Noninvasive Positive Pressure Ventilation in Pediatric Patients Admitted With Status Asthmaticus Withdrawn NCT01188473 Phase 1
20 A Prospective Analysis of the Use of Oral Montelukast in Children With Status Asthmaticus Unknown status NCT01770899 Montelukast;Placebo
21 Pharmacokinetics and Pharmacodynamics of Terbutaline Given as a Continuous Intravenous Infusion in Severe Status Asthmaticus Unknown status NCT00750568
22 Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma Unknown status NCT02112305 isotonic magnesium sulphate;50% magnesium sulphate
23 Risk Factors for Intensive Care Admission of Children With Severe Acute Wheeze or Asthma (SAA) Completed NCT02936778
24 B2-Adrenergic Receptor Polymorphisms: Implications For The Treatment Of Status Asthmaticus In Children Completed NCT00279786
25 High Frequency Chest Wall Oscillation in Hospital Management of Asthmatic Children Completed NCT00722020
26 Optimizing Vitamin D Status in Children With Pre-school Wheeze or Asthma:a Pilot Study (OPTIVIT) Completed NCT02880930
27 Effectiveness and Costs of Albuterol Delivered by MDI With Spacer Versus Nebulizer in Children Hospitalized With Moderate and Severe Asthma Exacerbations Completed NCT00623688
28 Using Pleth Variability to Triage Asthmatics in the Pediatric ED Completed NCT02302261
29 Effectiveness of the Aeroneb Compared to a Jet Nebulizer Fort the Delivery of Bronchodilator Therapy of Acute Severe Asthma Completed NCT03029156
30 High Flow Nasal Cannula Versus Standard Oxygen Therapy in Children With Status Asthmaticus: a Randomized Controlled Trial Recruiting NCT03157102
31 Pilot Randomized Control Trial of Telemedical Support for Paramedics in Simulated Pre-hospital Pediatric Emergencies Enrolling by invitation NCT03742167
32 Bilevel Positive Airway Pressure (BPAP) in Pediatric Asthma Exacerbations: A Pilot Study Not yet recruiting NCT04656587
33 Use of High Frequency Chest Compression (HFCC) in Pediatric Status Asthmaticus Terminated NCT00552448
34 A Prospective, Randomized Trial of Early Versus Delayed BiPAP Administration or Non-positive Pressure Therapy in the Management of Pediatric Status Asthmaticus Withdrawn NCT02539420
35 A Randomized Controlled Trial of Non-Invasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Withdrawn NCT03219736
36 A Prospective Open Randomized Clinical Trial Comparing Bilevel Positive Airway Pressure (BiPAP) Therapy Against Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma Unresponsive to Inhaled Bronchodilators. Withdrawn NCT02347462

Search NIH Clinical Center for Status Asthmaticus

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Enflurane
ethyl ether
Halothane
Hydrocortisone
hydrocortisone acetate
HYDROCORTISONE ACETATE PWDR
HYDROCORTISONE ACETONIDE
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
HYDROCORTISONE PWDR
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate
HYDROCORTISONE,NONSTERILE PWDR
Isoflurane

Cochrane evidence based reviews: status asthmaticus

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Genetic Tests for Status Asthmaticus

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Anatomical Context for Status Asthmaticus

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MalaCards organs/tissues related to Status Asthmaticus:

40
Eye, Medulla Oblongata, Trachea, Neutrophil, Smooth Muscle, Skin, Pituitary
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Publications for Status Asthmaticus

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Articles related to Status Asthmaticus:

(show top 50) (show all 1378)
# Title Authors PMID Year
1
Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. 61 54
16912630 2006
2
Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. 54 61
16395068 2006
3
Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. 61 54
12628991 2003
4
Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus. 61
31608716 2021
5
Systemic glucocorticoid at discharge after hospitalization for pediatric asthma: a prospective pilot study. 61
33492180 2021
6
Implementation of a Critical Care Asthma Pathway in the PICU. 61
33604577 2021
7
Comparison of Two Assessment Tools for Hospitalized Subjects With Asthma. 61
32962997 2021
8
Salbutamol-induced lactic acidosis in status asthmaticus survivor. 61
33435939 2021
9
High-flow nasal cannula and bilevel positive airway pressure for pediatric status asthmaticus: a single center, retrospective descriptive and comparative cohort study. 61
33401990 2021
10
Extracorporeal Carbon Dioxide Removal in the Treatment of Status Asthmaticus. 61
33031151 2020
11
Emergency Department Airway Management for Status Asthmaticus With Respiratory Failure. 61
32723860 2020
12
Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. 61
32896033 2020
13
Physiologically variable ventilation in a rabbit model of asthma exacerbation. 61
33070949 2020
14
Burden of Asthma in Elderly Japanese Patients: Using Hospital-Based Administrative Claims Data. 61
32504384 2020
15
Descriptions and outcomes of cardiac evaluations in pediatric patients hospitalized for asthma. 61
31288567 2020
16
Greater length of stay and hospital charges for severe asthma in children with depression or anxiety. 61
32902930 2020
17
Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. 61
31352844 2020
18
Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study. 61
33089387 2020
19
Bilevel Positive Airway Pressure ventilation efficiently improves respiratory distress in initial hours treating children with severe asthma exacerbation. 61
31806384 2020
20
Comparison of two continuous nebulized albuterol doses in critically ill children with status asthmaticus. 61
31119958 2020
21
A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency. 61
33043128 2020
22
Unsuspected foreign-body aspiration in adult patient with status asthmaticus: Case report. 61
32551105 2020
23
Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding. 61
31046509 2020
24
Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017. 61
32584247 2020
25
Terbutaline and aminophylline as second-line therapies for status asthmaticus in the pediatric intensive care unit. 61
32426910 2020
26
Usefulness of extracorporeal membrane oxygenation in status asthmaticus with severe tracheal stenosis. 61
32675965 2020
27
Improving the Pediatric Emergency Department Learning Experience: A Simulation-Based Orientation for Pediatric PGY 1 Residents. 61
32656335 2020
28
Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children. 61
32227683 2020
29
The Reemergence of Ketamine for Treatment in Critically Ill Adults. 61
32317593 2020
30
Pediatric Boot Camp Series: Longitudinal Care for a Child With Asthma-From the Emergency Department to Outpatient Clinic. 61
32656327 2020
31
Asthma deaths in North Carolina: 1999-2016. 61
30810458 2020
32
SCAMP-ering Toward Improved Quality of Care in Children With Status Asthmaticus. 61
32358332 2020
33
Standardized Protocol Is Associated With a Decrease in Continuous Albuterol Use and Length of Stay in Critical Status Asthmaticus. 61
32084098 2020
34
Outcome of status asthmaticus at a pediatric intensive care unit in Hong Kong. 61
31965725 2020
35
Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study. 61
32072493 2020
36
Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study. 61
32164622 2020
37
Status asthmaticus requiring extracorporeal membrane oxygenation associated with rhinovirus infection. 61
30882258 2020
38
Improving Influenza Vaccination in Hospitalized Children With Asthma. 61
32107285 2020
39
Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options. 61
31986238 2020
40
Association of various weight-based doses of continuous albuterol on hospital length of stay. 61
31994959 2020
41
A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature. 61
31860773 2020
42
Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus. 61
31432470 2020
43
Enoximone in status asthmaticus. 61
32280667 2020
44
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation. 61
31948977 2020
45
High-frequency oscillatory ventilation as a rescue for severe asthma crisis in a child. 61
32974029 2020
46
Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report. 61
32042585 2020
47
Neuromuscular blockade management in the critically Ill patient. 61
32483489 2020
48
Negative results for ketamine use in severe acute bronchospasm: a randomised controlled trial. 61
32876408 2020
49
Safety of prolonged magnesium sulfate infusions during treatment for severe pediatric status asthmaticus. 61
31478612 2019
50
High frequency percussive ventilation as a rescue mode for refractory status asthmaticus - a case study. 61
31668108 2019
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Variations for Status Asthmaticus

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Expression for Status Asthmaticus

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Search GEO for disease gene expression data for Status Asthmaticus.
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Pathways for Status Asthmaticus

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Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.78 RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN
2
PEDF Induced Signaling 63
Show member pathways
 13.53 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
3
TGF-Beta Pathway 63
Show member pathways
 13.4 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
4
Akt Signaling 63
Show member pathways
 13.22 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
5
PAK Pathway 63
Show member pathways
 13.09 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
6
Cytokine Signaling in Immune system 65
Show member pathways
 13.08 MMP9 MMP3 IL5 IL1RN IL1R1 IL10
7
Allograft rejection 36 1
Show member pathways
 12.72 RNASE3 IL5 IL10 CXCL8 CCL11
8
Immune response CCR3 signaling in eosinophils 23
Show member pathways
 12.21 CXCL8 CCL7 CCL5 CCL11
9
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.17 IL10 CXCL8 CCL7 CCL5 CCL11
10
Transcriptional misregulation in cancer 36
12.09 MMP9 MMP3 ELANE CXCL8
11
MAPK Pathway 70
Show member pathways
 11.91 PIK3C2A IL5 IL1R1
12
Spinal Cord Injury 1
11.88 MMP9 IL1R1 CXCL8
13
TNF signaling pathway 36
11.85 MMP9 MMP3 CCL5
14
Amoebiasis 36
11.8 IL1R1 IL10 CXCL8
15
Matrix Metalloproteinases 1
Show member pathways
 11.78 MMP9 MMP3 ELANE
16
Rheumatoid arthritis 36
11.74 MMP3 CXCL8 CCL5
17
Interleukin-4 and 13 signaling 65
11.71 MMP9 MMP3 IL10 CXCL8 CCL11
18
Innate Lymphoid Cell Differentiation Pathways 64
11.67 IL5 IL1R1 IL10
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.53 MMP9 MMP3 CXCL8
20
IL4-mediated signaling events 1
11.52 IL5 IL10 CCL11
21
Cell adhesion_ECM remodeling 23
11.5 MMP9 MMP3 CXCL8
22
IL-17 Family Signaling Pathways 64
Show member pathways
 11.5 MUC5AC MMP9 MMP3 IL5 CXCL8 CCL7
23
Lung fibrosis 1
11.35 MMP9 IL5 CXCL8 CCL5 CCL11
24
Th2 Differentiation Pathway 64
11.33 IL5 IL10 CCL11
25
Cell adhesion_Cell-matrix glycoconjugates 23
11.26 MMP9 MMP3 ELANE CCL5
26
Interleukin-10 signaling 65
11.04 IL1RN IL1R1 IL10 CXCL8 CCL5
27
Syndecan-1-mediated signaling events 1
10.86 MMP9 CCL5
28
G-protein signaling_Rap2B regulation pathway 23
10.84 IL5 IL10 CXCL8 CCL7 CCL5 CCL11
Sources

GO Terms for Status Asthmaticus

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Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN
2 extracellular region GO:0005576 9.44 RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
2 positive regulation of cell migration GO:0030335 9.88 MMP9 CCL7 CCL5 CCL11
3 cellular response to tumor necrosis factor GO:0071356 9.83 CXCL8 CCL7 CCL5 CCL11
4 cellular response to interferon-gamma GO:0071346 9.79 CCL7 CCL5 CCL11
5 cellular calcium ion homeostasis GO:0006874 9.76 ELANE CCL7 CCL5 CCL11
6 extracellular matrix disassembly GO:0022617 9.74 MMP9 MMP3 ELANE
7 monocyte chemotaxis GO:0002548 9.72 CCL7 CCL5 CCL11
8 cellular response to interleukin-1 GO:0071347 9.71 CXCL8 CCL7 CCL5 CCL11
9 inflammatory response GO:0006954 9.7 IL5 IL1RN IL1R1 CXCL8 CCL7 CCL5
10 lymphocyte chemotaxis GO:0048247 9.69 CCL7 CCL5 CCL11
11 positive regulation of JAK-STAT cascade GO:0046427 9.67 IL5 IL10 CCL5
12 neutrophil chemotaxis GO:0030593 9.67 CXCL8 CCL7 CCL5 CCL11
13 chemotaxis GO:0006935 9.65 RNASE3 CXCL8 CCL7 CCL5 CCL11
14 positive regulation of immunoglobulin production GO:0002639 9.63 IL5 IL10
15 response to amyloid-beta GO:1904645 9.63 MMP9 MMP3
16 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CXCL8 CCL5
17 neutrophil activation GO:0042119 9.62 CXCL8 CCL5
18 chemokine-mediated signaling pathway GO:0070098 9.62 CXCL8 CCL7 CCL5 CCL11
19 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 MMP3
20 eosinophil chemotaxis GO:0048245 9.61 CCL7 CCL5 CCL11
21 cellular response to UV-A GO:0071492 9.6 MMP9 MMP3
22 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.59 IL1RN IL10
23 response to molecule of bacterial origin GO:0002237 9.58 IL10 CXCL8
24 positive regulation of natural killer cell chemotaxis GO:2000503 9.56 CCL7 CCL5
25 immune response GO:0006955 9.56 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
26 positive regulation of cellular biosynthetic process GO:0031328 9.54 CXCL8 CCL5
27 cytokine-mediated signaling pathway GO:0019221 9.28 MMP9 MMP3 IL5 IL1RN IL1R1 IL10

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP3 ELANE
2 CCR chemokine receptor binding GO:0048020 9.33 CCL7 CCL5 CCL11
3 CCR1 chemokine receptor binding GO:0031726 9.26 CCL7 CCL5
4 chemokine activity GO:0008009 9.26 CXCL8 CCL7 CCL5 CCL11
5 cytokine activity GO:0005125 9.17 IL5 IL1RN IL10 CXCL8 CCL7 CCL5
Sources

Sources for Status Asthmaticus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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