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MCID: STT002
MIFTS: 50

Status Asthmaticus

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Status Asthmaticus

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MalaCards integrated aliases for Status Asthmaticus:

Name: Status Asthmaticus 12 54 43 15 17 71 32
Asthma with Status Asthmaticus 12
Severe Asthma Attack 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:9362
ICD9CM 34 493.91
MeSH 43 D013224
NCIt 49 C122577
SNOMED-CT 67 708090002
ICD10 32 J46
UMLS 71 C0038218
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Summaries for Status Asthmaticus

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Disease Ontology : 12 An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment.

MalaCards based summary : Status Asthmaticus, also known as asthma with status asthmaticus, is related to allergic asthma and bronchopneumonia. An important gene associated with Status Asthmaticus is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Dobutamine and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and prostate, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not... more...

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Related Diseases for Status Asthmaticus

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Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 367)
# Related Disease Score Top Affiliating Genes
1 allergic asthma 31.7 RNASE3 IL5 IL13 IL10 CXCL8 CCL5
2 bronchopneumonia 30.2 IL10 ELANE CXCL8
3 bacterial pneumonia 30.1 IL10 ELANE CXCL8
4 pulmonary emphysema 30.0 MMP9 ELANE CXCL8
5 ige responsiveness, atopic 30.0 RNASE3 IL5 IL13 IL10
6 duodenal ulcer 29.9 IL1RN IL10 CXCL8
7 adult respiratory distress syndrome 29.8 IL1R1 IL10 ELANE CXCL8 ADRB2
8 pertussis 29.8 IL10 CXCL8 CCL5 CCL11
9 traumatic brain injury 29.6 MMP9 IL10
10 pulmonary edema 29.6 PIK3C2A IL13 IL10 CXCL8
11 neutropenia 29.5 IL1RN IL10 ELANE CXCL8
12 gastritis 29.5 IL1RN IL10 CXCL8 CCL5
13 dermatitis 29.3 IL5 IL13 IL10 CXCL8 CCL11
14 cerebral palsy 29.3 IL13 IL10 CXCL8 CCL7 ADRB2
15 esophagitis 29.1 IL5 IL13 IL10 CXCL8 CCL5 CCL11
16 hypereosinophilic syndrome 29.0 RNASE3 IL5 IL13 IL10 CXCL8 CCL5
17 allergic rhinitis 29.0 RNASE3 IL5 IL13 IL10 CXCL8 CCL5
18 asthma 28.7 RNASE3 MUC5AC MMP9 IL5 IL1RN IL1R1
19 rhinitis 28.6 RNASE3 IL5 IL13 IL10 CXCL8 CCL7
20 bronchitis 28.6 RNASE3 MMP9 IL5 IL13 IL10 ELANE
21 allergic hypersensitivity disease 28.4 RNASE3 IL5 IL13 IL10 CXCL8 CCL7
22 myocardial infarction 28.0 PIK3C2A MMP9 MMP3 IL1RN IL10 CXCL8
23 respiratory failure 27.9 RNASE3 PIK3C2A MUC5AC IL5 IL1RN IL1R1
24 lung disease 27.2 RNASE3 MUC5B MUC5AC MMP9 IL5 IL13
25 proteasome-associated autoinflammatory syndrome 1 26.9 RNASE3 MMP9 IL5 IL1RN IL1R1 IL13
26 otitis media 26.5 RNASE3 MUC5B MUC5AC IL5 IL1RN IL13
27 pneumonia 26.0 PIK3C2A MUC5B MMP9 IL5 IL1RN IL13
28 myopathy 10.6
29 pneumothorax 10.6
30 loeffler endocarditis 10.5 RNASE3 IL5
31 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.4
32 atopic keratoconjunctivitis 10.4 RNASE3 MUC5AC IL5
33 metabolic acidosis 10.3
34 pemphigoid gestationis 10.3 RNASE3 IL5 CCL11
35 spotted fever rickettsiosis 10.3 IL10 CCL5
36 neurosyphilis 10.3 IL10 CXCL8
37 eosinophilic gastroenteritis 10.3 RNASE3 IL5 CCL11
38 myoglobinuria 10.3
39 quadriplegia 10.3
40 cytokine deficiency 10.3 IL5 IL13
41 nut allergy 10.3 IL5 IL13
42 lung mucoepidermoid carcinoma 10.3 MUC5AC CXCL8
43 giant papillary conjunctivitis 10.3 RNASE3 CXCL8 CCL11
44 aztreonam allergy 10.3 IL5 IL13
45 endomyocardial fibrosis 10.3 RNASE3 IL5 IL10
46 toxocariasis 10.3 RNASE3 IL5 IL10
47 cow milk allergy 10.3 RNASE3 IL5 IL10
48 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
49 folliculitis 10.3 IL5 CCL5 CCL11
50 cefaclor allergy 10.2 IL5 IL13

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 13)


Anxiety Asthma
Bronchitis Chronic Maxillary Sinusitis
Chronic Pulmonary Heart Disease Conn's Syndrome
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Oral Candidiasis Osteoporosis
Respiratory Failure

Graphical network of the top 20 diseases related to Status Asthmaticus:



Diseases related to Status Asthmaticus
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Symptoms & Phenotypes for Status Asthmaticus

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MGI Mouse Phenotypes related to Status Asthmaticus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 ADRB2 CCL11 CCL5 ELANE IL10 IL13
2 homeostasis/metabolism MP:0005376 9.93 ADRB2 ELANE IL10 IL13 IL1R1 IL1RN
3 immune system MP:0005387 9.8 ADRB2 CCL11 CCL5 ELANE IL10 IL13
4 respiratory system MP:0005388 9.17 CCL11 IL10 IL13 IL1R1 IL5 MMP9
Sources

Drugs & Therapeutics for Status Asthmaticus

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Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dobutamine Approved Phase 4 34368-04-2 36811
2
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
3
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
8 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
9
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
10
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
11
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
12 Neuroprotective Agents Phase 4
13 Protective Agents Phase 4
14 Cholinergic Antagonists Phase 4
15 Anti-Arrhythmia Agents Phase 4
16 Anticonvulsants Phase 4
17 Calcium, Dietary Phase 4
18 calcium channel blockers Phase 4
19 Formoterol Fumarate Phase 4
20
Beclomethasone Phase 4 4419-39-0 20469
21 Adrenergic beta-Agonists Phase 4
22 Adrenergic Agents Phase 4
23 Adrenergic Agonists Phase 4
24 Tocolytic Agents Phase 4
25 Sympathomimetics Phase 4
26 Adrenergic alpha-Agonists Phase 4
27 Vasoconstrictor Agents Phase 4
28 Mydriatics Phase 4
29 Neurotransmitter Agents Phase 4
30 Anesthetics Phase 4
31 Excitatory Amino Acid Antagonists Phase 4
32 Anesthetics, Dissociative Phase 4
33 Anesthetics, General Phase 4
34 Anesthetics, Intravenous Phase 4
35 Analgesics Phase 4
36 Pharmaceutical Solutions Phase 4
37 Hormones Phase 4
38 Antineoplastic Agents, Hormonal Phase 4
39 Hormone Antagonists Phase 4
40 glucocorticoids Phase 4
41 Methylprednisolone Acetate Phase 4
42 Antiemetics Phase 4
43 Gastrointestinal Agents Phase 4
44 Anti-Inflammatory Agents Phase 4
45 BB 1101 Phase 4
46
Calcium Nutraceutical Phase 4 7440-70-2 271
47
Montelukast Approved Phase 2, Phase 3 158966-92-8 5281040
48
Budesonide Approved Phase 3 51333-22-3 63006 5281004
49 Leukotriene Antagonists Phase 2, Phase 3
50 Respiratory System Agents Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Efficacy of a Loading Dose of IV Salbutamol in Children Admitted to a PICU for Severe Acute Asthma or Severe Acute Wheeze Unknown status NCT03493503 Phase 4 Salbutamol;Sodium Chloride 0.9%
2 Extra-fine Formoterol/Beclomethasone in the Treatment of Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
3 Efficacy of Nebulized Magnesium Sulfate as an Adjunct to Standard Therapy in Asthma Exacerbation. A Randomized Controlled Trial Unknown status NCT02584738 Phase 4 Nebulized Magnesium Sulfate;Nebulized isotonic saline;Nebulized Salbutamol;Ipratropium bromide;Methylprednisolone or Prednisolone
4 MRI With a Lymph Node Specific Contrast Agent: an Alternative for CT-Scanning and Lymph Node Dissection in Patients With Prostate Cancer? Unknown status NCT00185029 Phase 4
5 Double-blinded Randomized Trial of Terbutaline to Shorten ICU Length of Stay in the Treatment of Status Asthmaticus in Children Completed NCT00124995 Phase 4 terbutaline
6 Continuous Levalbuterol for Treatment of Status Asthmaticus in Children Completed NCT00124176 Phase 4 Racemic albuterol (R+S albuterol);Levalbuterol (R albuterol)
7 Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation Completed NCT01705964 Phase 4 IM epinephrine 1:1000
8 Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis Completed NCT01310790 Phase 4
9 Pre-hospital Utilization of Nebulized Sub-dissociative Dose Ketamine for Managing Acute Traumatic Extremity Pain: a Prospective Observational Study Recruiting NCT04162028 Phase 4 Nebutlized Ketamine
10 Comparison of Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED: A Prospective, Randomized Double-Blind Trial Recruiting NCT03950817 Phase 4 Nebulized Sub-dissociative Dose Ketamine at either 0.75 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1 mg/kg;Nebulized Sub-dissociative Dose Ketamine at 1.5 mg/kg.
11 Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit Enrolling by invitation NCT03900624 Phase 4 Dexamethasone
12 Comparison of Benzalkonium Chloride Containing Albuterol Versus Preservative Free Albuterol for the Treatment of Status Asthmaticus Suspended NCT02966184 Phase 4 preservative free albuterol
13 Oral Dexamethasone Versus Oral Prednisone in Children Hospitalized With Asthma: A Randomized Control Study Terminated NCT02780479 Phase 4 Dexamethasone;Prednisone
14 Pharmacokinetics and Pharmacodynamics of Montelukast in Children, Ages 6 Through 18 Years Old, With Status Asthmaticus Unresponsive to Conventional Treatment Unknown status NCT00494572 Phase 2, Phase 3 Montelukast
15 Montelukast With Status Asthmaticus, Ages 2-5 Unknown status NCT00491790 Phase 2, Phase 3 Montelukast
16 The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room Completed NCT01524198 Phase 2, Phase 3 Budesonide;Normal saline
17 Effectiveness of Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Acute Asthma in Children in Suez Canal University Hospital Emergency Department: A Randomized Control Trial Completed NCT03816267 Phase 3 Salbutamol
18 Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose With/Without Nebulized Budesonide for the Emergency Management of the Severe Asthma. A Randomized Controlled Trial. Recruiting NCT02455687 Phase 3 Hi-dose iv MgSO4;Nebulized budesonide;Std-dose iv MgSO4;Nebulized normal saline
19 The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study Not yet recruiting NCT03338205 Phase 3 Ketamine
20 A Prospective, Randomized, Controlled, Single Center Trial of the Use of Heliox in Children Admitted to the Hospital With Status Asthmaticus Terminated NCT00410150 Phase 2 Helium-oxygen-driven albuterol nebulizer;Oxygen
21 A Randomized, Double-blinded or Evaluator-blinded, Placebo and Active Controlled, Six-arm, Crossover, Single Dose, Dose-ranging Study, for Initial Evaluation of Safety and Efficacy in Asthma Patients Terminated NCT01025648 Phase 1, Phase 2 E004 (epinephrine inhalation aerosol), 90 mcg/actuation;E004 Placebo;E004 (epinephrine inhalation aerosol), 125 mcg;E004 (epinephrine inhalation aerosol), 220 mcg;epinephrine inhalation aerosol, CFC propelled;E004 (epinephrine inhalation aerosol), 160 mcg
22 A Phase II, Randomized, Modified Single-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of MN-221 When Administered Intravenously as an Adjunct to Standard Therapy to Adults With an Acute Exacerbation of Asthma Terminated NCT00683449 Phase 2 Dose Group 1;MN-221 placebo;Dose Group 2;Dose Group 3
23 Effect Of Early Initiation Of Noninvasive Positive Pressure Ventilation On ICU Length Of Stay In Children With Status Asthmaticus, A Prospective Randomized Trial Withdrawn NCT01403428 Phase 2
24 A Phase I, Single Center, Placebo-Controlled, Blinded Pilot Study of Ipratropium Bromide in Children Admitted to the Intensive Care Unit With Status Asthmaticus Completed NCT02872597 Phase 1 Ipratropium;0.9% Sodium Chloride;Albuterol;corticosteroids
25 High Fidelity Simulation (HFS) Versus Video-case(VC) Trainings in the Assessement and Management of Severe Asthma Attack Among Medical School Students: a Randomized Controlled Study Completed NCT02776358 Phase 1
26 Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Managed in the Emergency Department: A Randomized Controlled Trial Recruiting NCT04016220 Phase 1 Budesonide;normal saline
27 Safety and Efficacy of Early Initiation of Noninvasive Positive Pressure Ventilation in Pediatric Patients Admitted With Status Asthmaticus Withdrawn NCT01188473 Phase 1
28 Pharmacokinetics and Pharmacodynamics of Terbutaline Given as a Continuous Intravenous Infusion in Severe Status Asthmaticus Unknown status NCT00750568
29 A Prospective Analysis of the Use of Oral Montelukast in Children With Status Asthmaticus Unknown status NCT01770899 Montelukast;Placebo
30 Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma Unknown status NCT02112305 isotonic magnesium sulphate;50% magnesium sulphate
31 A Real Life Evaluation of the Performance of a Large Volume Nebulizer Unknown status NCT00632112
32 Salbutamol in the Pediatric Emergencies: Nebulization Estimated Via AerogeN or Jet Unknown status NCT03042065
33 Risk Factors for Intensive Care Admission of Children With Severe Acute Wheeze or Asthma (SAA) Completed NCT02936778
34 High Frequency Chest Wall Oscillation in Hospital Management of Asthmatic Children Completed NCT00722020
35 Using Pleth Variability to Triage Asthmatics in the Pediatric ED Completed NCT02302261
36 B2-Adrenergic Receptor Polymorphisms: Implications For The Treatment Of Status Asthmaticus In Children Completed NCT00279786
37 Stimulation of the Cervical Sympathetic Ganglion for Treatment of Asthma. Completed NCT01724307
38 Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma Completed NCT01227070
39 Effectiveness and Costs of Albuterol Delivered by MDI With Spacer Versus Nebulizer in Children Hospitalized With Moderate and Severe Asthma Exacerbations Completed NCT00623688
40 Community - Based Asthma Intervention in Subsidized Preschools Completed NCT00304304
41 Effectiveness of the Aeroneb Compared to a Jet Nebulizer Fort the Delivery of Bronchodilator Therapy of Acute Severe Asthma Completed NCT03029156
42 Optimizing Vitamin D Status in Children With Pre-school Wheeze or Asthma:a Pilot Study (OPTIVIT) Completed NCT02880930
43 The Impact of High-Flow Nasal Cannula on Swallow Function Completed NCT03590457
44 High Flow Nasal Cannula Versus Standard Oxygen Therapy in Children With Status Asthmaticus: a Randomized Controlled Trial Recruiting NCT03157102
45 Efficacy of Two Doses of Parenteral Amoxicillin Plus Single Dose Gentamicin Compared to Four Doses of Parenteral Ampicillin Plus Single Dose Gentamicin in Managing Children Hospitalized With WHO Classified Severe Pneumonia: a RCT Recruiting NCT03369093 Amoxicillin
46 Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care Active, not recruiting NCT00458926
47 Randomized Control Trial of Telemedical Support for Paramedics in Simulated Pre-hospital Pediatric Emergencies Suspended NCT03742167
48 Use of High Frequency Chest Compression (HFCC) in Pediatric Status Asthmaticus Terminated NCT00552448
49 A Prospective, Randomized Trial of Early Versus Delayed BiPAP Administration or Non-positive Pressure Therapy in the Management of Pediatric Status Asthmaticus Withdrawn NCT02539420
50 A Prospective Open Randomized Clinical Trial Comparing Bilevel Positive Airway Pressure (BiPAP) Therapy Against Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma Unresponsive to Inhaled Bronchodilators. Withdrawn NCT02347462

Search NIH Clinical Center for Status Asthmaticus

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Enflurane
ethyl ether
Halothane
Hydrocortisone
hydrocortisone acetate
HYDROCORTISONE ACETATE PWDR
HYDROCORTISONE ACETONIDE
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
HYDROCORTISONE PWDR
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate
HYDROCORTISONE,NONSTERILE PWDR
Isoflurane

Cochrane evidence based reviews: status asthmaticus

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Genetic Tests for Status Asthmaticus

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Anatomical Context for Status Asthmaticus

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MalaCards organs/tissues related to Status Asthmaticus:

40
Lung, Lymph Node, Prostate, Heart, Brain, Testes, Eye
Sources

Publications for Status Asthmaticus

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Articles related to Status Asthmaticus:

(show top 50) (show all 1365)
# Title Authors PMID Year
1
Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. 54 61
16912630 2006
2
Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. 61 54
16395068 2006
3
Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. 61 54
12628991 2003
4
Unsuspected foreign-body aspiration in adult patient with status asthmaticus: Case report. 61
32551105 2020
5
Terbutaline and aminophylline as second-line therapies for status asthmaticus in the pediatric intensive care unit. 61
32426910 2020
6
Burden of Asthma in Elderly Japanese Patients: Using Hospital-Based Administrative Claims Data. 61
32504384 2020
7
The Reemergence of Ketamine for Treatment in Critically Ill Adults. 61
32317593 2020
8
Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children. 61
32227683 2020
9
Asthma deaths in North Carolina: 1999-2016. 61
30810458 2020
10
Outcome of status asthmaticus at a pediatric intensive care unit in Hong Kong. 61
31965725 2020
11
SCAMP-ering Toward Improved Quality of Care in Children With Status Asthmaticus. 61
32358332 2020
12
Standardized Protocol Is Associated With a Decrease in Continuous Albuterol Use and Length of Stay in Critical Status Asthmaticus. 61
32084098 2020
13
Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study. 61
32072493 2020
14
Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study. 61
32164622 2020
15
Improving Influenza Vaccination in Hospitalized Children With Asthma. 61
32107285 2020
16
Status asthmaticus requiring extracorporeal membrane oxygenation associated with rhinovirus infection. 61
30882258 2020
17
Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options. 61
31986238 2020
18
A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature. 61
31860773 2020
19
Association of various weight-based doses of continuous albuterol on hospital length of stay. 61
31994959 2020
20
Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus. 61
31432470 2020
21
Neuromuscular blockade management in the critically Ill patient. 61
32483489 2020
22
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation. 61
31948977 2020
23
Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report. 61
32042585 2020
24
Enoximone in status asthmaticus. 61
32280667 2020
25
Bilevel Positive Airway Pressure ventilation efficiently improves respiratory distress in initial hours treating children with severe asthma exacerbation. 61
31806384 2019
26
Safety of prolonged magnesium sulfate infusions during treatment for severe pediatric status asthmaticus. 61
31478612 2019
27
High frequency percussive ventilation as a rescue mode for refractory status asthmaticus - a case study. 61
31668108 2019
28
Successful Treatment of Refractory Status Asthmaticus Accompanied by Right Ventricular Dysfunction Using a Protek Duo Tandem Heart Device. 61
31076305 2019
29
Predictors of severe asthma attack re-attendance in Ecuadorian children: a cohort study. 61
31515399 2019
30
Acute severe asthma (status asthmaticus). 61
31690381 2019
31
Continuous Albuterol in Pediatric Acute Care: Study Demonstrates Safety Outside the Intensive Care Unit. 61
32010852 2019
32
Implementing a Respiratory Therapist-Driven Continuous Albuterol Weaning Protocol in the Pediatric ICU. 61
30890627 2019
33
Procalcitonin Levels in Critically Ill Children With Status Asthmaticus. 61
31593980 2019
34
Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus. 61
31608716 2019
35
Refractory Status Asthmaticus: Treatment With Sevoflurane. 61
31768099 2019
36
Tonsillectomy does not reduce asthma in children: A longitudinal follow-up study using a national sample cohort. 61
31527814 2019
37
Novel pediatric-automated respiratory score using physiologic data and machine learning in asthma. 61
31006993 2019
38
Current Use of Neuromuscular Blocking Agents in Intensive Care Units. 61
31380507 2019
39
Descriptions and outcomes of cardiac evaluations in pediatric patients hospitalized for asthma. 61
31288567 2019
40
Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. 61
31352844 2019
41
Comparison of two continuous nebulized albuterol doses in critically ill children with status asthmaticus. 61
31119958 2019
42
Characteristics and outcomes of treatment in status asthmaticus patients at emergency department. 61
29888929 2019
43
Pharmacokinetics of Ketamine at Dissociative Doses in an Adult Patient With Refractory Status Asthmaticus Receiving Extracorporeal Membrane Oxygenation Therapy. 61
30929859 2019
44
School Nurses on the Front Lines of Medicine: Emergencies Associated With Sport and Physical Activities: Part 1. 61
30741088 2019
45
Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding. 61
31046509 2019
46
Persistent hypoxemia after an asthma attack. 61
31359291 2019
47
Predictors of Hospital Reuse Among Publicly Insured Children Hospitalized for Status Asthmaticus. 61
30718385 2019
48
Omalizumab Rescue Therapy for Refractory Status Asthmaticus. 61
30458534 2019
49
The anatomic substrate of irreversible airway obstruction and barotrauma in a case of hurricane-triggered fatal status asthmaticus during puerperium: Lessons from an autopsy. 61
30603604 2019
50
Subdissociative Ketamine Use in the Emergency Department. 61
30702529 2019
Sources

Variations for Status Asthmaticus

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Expression for Status Asthmaticus

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Search GEO for disease gene expression data for Status Asthmaticus.
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Pathways for Status Asthmaticus

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Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.81 RNASE3 MUC5B MUC5AC MMP9 MMP3 IL5
2
ERK Signaling 63
Show member pathways
 13.74 IL5 IL1R1 IL13 IL10 CXCL8 CCL7
3
PEDF Induced Signaling 63
Show member pathways
 13.57 IL5 IL1RN IL1R1 IL13 IL10 CXCL8
4
TGF-Beta Pathway 63
Show member pathways
 13.44 IL5 IL1R1 IL13 IL10 CXCL8 CCL7
5
Akt Signaling 63
Show member pathways
 13.31 IL5 IL1R1 IL13 IL10 CXCL8 CCL7
6
PAK Pathway 63
Show member pathways
 13.18 IL5 IL1R1 IL13 IL10 CXCL8 CCL7
7
Cytokine Signaling in Immune system 65
Show member pathways
 13.13 MMP9 MMP3 IL5 IL1RN IL1R1 IL13
8
Allograft rejection 1 36
Show member pathways
 12.74 RNASE3 IL5 IL13 IL10 CXCL8 CCL11
9
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.62 MUC5B MUC5AC IL1RN IL1R1 CXCL8
10
Th17 cell differentiation 36
Show member pathways
 12.51 IL5 IL1R1 IL13 IL10
11
Apoptosis Pathway 70
Show member pathways
 12.36 PIK3C2A IL5 IL1R1 IL13
12
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 12.27 CXCL8 CCL7 CCL5 CCL11
13
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.23 IL10 CXCL8 CCL7 CCL5 CCL11
14
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.18 IL5 IL13 IL10 CXCL8
15
Transcriptional misregulation in cancer 36
12.18 MMP9 MMP3 ELANE CXCL8
16
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.09 IL1RN IL13 IL10 CXCL8
17
MAPK Pathway 70
Show member pathways
 11.96 PIK3C2A IL5 IL1R1 IL13
18
Spinal Cord Injury 1
11.93 MMP9 IL1R1 CXCL8
19
TNF signaling pathway 36
11.88 MMP9 MMP3 CCL5
20
Amoebiasis 36
11.84 IL1R1 IL10 CXCL8
21
Matrix Metalloproteinases 1
Show member pathways
 11.82 MMP9 MMP3 ELANE
22
Rheumatoid arthritis 36
11.79 MMP3 CXCL8 CCL5
23
Interleukin-4 and 13 signaling 65
11.79 MMP9 MMP3 IL13 IL10 CXCL8 CCL11
24
Glucocorticoid receptor regulatory network 1
11.72 IL5 IL13 CXCL8
25
Innate Lymphoid Cells Differentiation 64
11.68 IL5 IL1R1 IL13 IL10
26
IL-17 Family Signaling Pathways 64
Show member pathways
 11.61 MUC5B MUC5AC MMP9 MMP3 IL5 IL13
27
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 MMP9 MMP3 CXCL8
28
IL4-mediated signaling events 1
11.59 IL5 IL10 CCL11
29
Cell adhesion_ECM remodeling 22
11.57 MMP9 MMP3 CXCL8
30
Th2 Differentiation 64
11.4 IL5 IL13 IL10 CCL11
31
Interleukin-10 signaling 65
11.32 IL1RN IL1R1 IL13 IL10 CXCL8 CCL5
32
Cell adhesion_Cell-matrix glycoconjugates 22
11.3 MMP9 MMP3 ELANE CCL5
33
Lung fibrosis 1
11.3 MUC5B MMP9 IL5 IL13 CXCL8 CCL5
34
Cytokines and Inflammatory Response 1
11.19 IL5 IL13 IL10
35
OX40 Pathway 63
11.13 IL5 IL13 IL10
36
Syndecan-1-mediated signaling events 1
10.9 MMP9 CCL5
37
G-protein signaling_Rap2B regulation pathway 22
10.9 IL5 IL13 IL10 CXCL8 CCL7 CCL5
38
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.72 IL5 IL13
Sources

GO Terms for Status Asthmaticus

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Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 RNASE3 MUC5B MUC5AC MMP9 MMP3 IL5
2 extracellular region GO:0005576 9.5 RNASE3 MUC5B MUC5AC MMP9 MMP3 IL5

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
2 positive regulation of cell migration GO:0030335 9.88 MMP9 CCL7 CCL5 CCL11
3 chemotaxis GO:0006935 9.83 CXCL8 CCL7 CCL5 CCL11
4 cellular response to tumor necrosis factor GO:0071356 9.81 CXCL8 CCL7 CCL5 CCL11
5 cellular response to interferon-gamma GO:0071346 9.79 CCL7 CCL5 CCL11
6 inflammatory response GO:0006954 9.76 IL5 IL1RN IL1R1 IL13 CXCL8 CCL7
7 extracellular matrix disassembly GO:0022617 9.74 MMP9 MMP3 ELANE
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 IL13 ELANE CCL5
9 cellular calcium ion homeostasis GO:0006874 9.73 ELANE CCL7 CCL5 CCL11
10 monocyte chemotaxis GO:0002548 9.71 CCL7 CCL5 CCL11
11 lymphocyte chemotaxis GO:0048247 9.67 CCL7 CCL5 CCL11
12 cellular response to interleukin-1 GO:0071347 9.67 CXCL8 CCL7 CCL5 CCL11
13 positive regulation of JAK-STAT cascade GO:0046427 9.63 IL5 IL10 CCL5
14 response to amyloid-beta GO:1904645 9.62 MMP9 MMP3
15 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CXCL8 CCL5
16 neutrophil chemotaxis GO:0030593 9.62 CXCL8 CCL7 CCL5 CCL11
17 neutrophil activation GO:0042119 9.61 CXCL8 CCL5
18 immune response GO:0006955 9.61 IL5 IL1RN IL1R1 IL13 IL10 CXCL8
19 regulation of neuroinflammatory response GO:0150077 9.6 MMP9 MMP3
20 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.59 IL1RN IL10
21 response to molecule of bacterial origin GO:0002237 9.58 IL10 CXCL8
22 eosinophil chemotaxis GO:0048245 9.58 CCL7 CCL5 CCL11
23 chemokine-mediated signaling pathway GO:0070098 9.56 CXCL8 CCL7 CCL5 CCL11
24 positive regulation of natural killer cell chemotaxis GO:2000503 9.55 CCL7 CCL5
25 cytokine-mediated signaling pathway GO:0019221 9.32 MMP9 MMP3 IL5 IL1RN IL1R1 IL13

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP3 ELANE
2 CCR chemokine receptor binding GO:0048020 9.33 CCL7 CCL5 CCL11
3 CCR1 chemokine receptor binding GO:0031726 9.26 CCL7 CCL5
4 chemokine activity GO:0008009 9.26 CXCL8 CCL7 CCL5 CCL11
5 cytokine activity GO:0005125 9.23 IL5 IL1RN IL13 IL10 CXCL8 CCL7
Sources

Sources for Status Asthmaticus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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