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MCID: STT002
MIFTS: 45

Status Asthmaticus

Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Status Asthmaticus

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MalaCards integrated aliases for Status Asthmaticus:

Name: Status Asthmaticus 12 55 44 15 73
Asthma with Status Asthmaticus 12
Severe Asthma Attack 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:9362
ICD9CM 35 493.91
MeSH 44 D013224
NCIt 50 C122577
ICD10 33 J46
UMLS 73 C0038218
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Summaries for Status Asthmaticus

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Disease Ontology : 12 An asthma that is a life threatening condition with progressive respiratory failure, which does not respond to standard treatment.

MalaCards based summary : Status Asthmaticus, also known as asthma with status asthmaticus, is related to respiratory failure and allergic asthma. An important gene associated with Status Asthmaticus is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Immune response CCR3 signaling in eosinophils and IL-17 Family Signaling Pathways. The drugs Montelukast and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and neutrophil.

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Related Diseases for Status Asthmaticus

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Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 respiratory failure 30.3 CXCL8 ELANE PIK3C2A
2 allergic asthma 30.2 CCL5 CXCL8 IL5 RNASE3
3 alpha-1-antitrypsin deficiency 29.8 CXCL8 ELANE
4 sinusitis 29.7 CXCL8 IL5 RNASE3
5 bronchitis 28.8 CXCL8 ELANE IL5 RNASE3
6 asthma 28.1 ADRB2 CCL5 CCL7 CXCL8 ELANE IL5
7 pneumonia 27.4 CCL5 CXCL8 ELANE IL5 PIK3C2A
8 acute mountain sickness 10.5 ADRB2 PIK3C2A
9 trichinosis 10.5 IL5 PIK3C2A
10 loeffler endocarditis 10.5 IL5 RNASE3
11 cough variant asthma 10.5 IL5 RNASE3
12 inflammatory bowel disease 4 10.5 IL5 RNASE3
13 cow milk allergy 10.5 IL5 RNASE3
14 paragonimiasis 10.5 IL5 RNASE3
15 intrinsic asthma 10.5 IL5 RNASE3
16 atopic keratoconjunctivitis 10.5 IL5 RNASE3
17 eosinophilic gastroenteritis 10.4 IL5 RNASE3
18 latex allergy 10.4 IL5 RNASE3
19 urinary schistosomiasis 10.4 IL5 RNASE3
20 cryptogenic organizing pneumonia 10.4 CXCL8 PIK3C2A
21 erysipelas 10.4 ELANE PIK3C2A
22 cellulitis 10.4 IL5 RNASE3
23 toxic myocarditis 10.4 CXCL8 PIK3C2A
24 conjunctival disease 10.4 IL5 RNASE3
25 giant papillary conjunctivitis 10.4 CXCL8 RNASE3
26 milk allergy 10.4 IL5 RNASE3
27 elephantiasis 10.4 ELANE RNASE3
28 churg-strauss syndrome 10.4 IL5 RNASE3
29 bagassosis 10.4 CXCL8 IL5
30 necatoriasis 10.3 CXCL8 IL5
31 parasitic helminthiasis infectious disease 10.3 IL5 RNASE3
32 leptospirosis 10.3 CXCL8 PIK3C2A
33 pustulosis palmaris et plantaris 10.3 ELANE IL5
34 felty syndrome 10.3 CXCL8 ELANE
35 food allergy 10.2 IL5 RNASE3
36 cardiac rupture 10.2 CXCL8 ELANE
37 pulmonary edema 10.2 CXCL8 PIK3C2A
38 cyclic neutropenia 10.2 CXCL8 ELANE
39 capillary leak syndrome 10.2 CXCL8 ELANE
40 myopathy 10.2
41 periodontosis 10.2 CXCL8 ELANE
42 disseminated intravascular coagulation 10.2 ELANE PIK3C2A
43 bacterial meningitis 10.2 CXCL8 PIK3C2A
44 acute respiratory distress syndrome 10.1 CXCL8 ELANE
45 pollen allergy 10.1 ADRB2 IL5 RNASE3
46 allergic contact dermatitis 10.1 CXCL8 IL5
47 adult respiratory distress syndrome 10.1 CXCL8 ELANE
48 endocarditis 10.1 CXCL8 PIK3C2A
49 ige responsiveness, atopic 10.1 ADRB2 IL5 RNASE3
50 chorioamnionitis 10.1 CXCL8 ELANE

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 14)


Anxiety Asthma
Bronchitis Chronic Maxillary Sinusitis
Chronic Myocardial Ischemia Chronic Pulmonary Heart Disease
Conn's Syndrome Esophagitis
Heart Disease Hypertension, Essential
Hypothyroidism Oral Candidiasis
Osteoporosis Respiratory Failure

Graphical network of the top 20 diseases related to Status Asthmaticus:



Diseases related to Status Asthmaticus
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Symptoms & Phenotypes for Status Asthmaticus

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Drugs & Therapeutics for Status Asthmaticus

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Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4,Phase 2,Phase 3,Not Applicable 158966-92-8 5281040
2
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-24-8 5755
3
Terbutaline Approved Phase 4,Not Applicable 23031-25-6 5403
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 83-43-2 6741
5
Ciclesonide Approved, Investigational Phase 4 126544-47-6, 141845-82-1 444033
6
Epinephrine Approved, Vet_approved Phase 4,Phase 1,Phase 2,Not Applicable 51-43-4 5816
7
Racepinephrine Approved Phase 4,Phase 1,Phase 2,Not Applicable 329-65-7 838
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
9
Prednisone Approved, Vet_approved Phase 4,Phase 1 53-03-2 5865
10 Prednisolone acetate Phase 4,Phase 2,Phase 3,Phase 1
11
Beclomethasone Phase 4 4419-39-0 20469
12 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
13 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Methylprednisolone acetate Phase 4,Phase 2,Phase 3,Phase 1
15 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3,Phase 1
16 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
17 Adrenergic Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Adrenergic beta-2 Receptor Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
19 Adrenergic beta-Agonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 Formoterol Fumarate Phase 4
21 Albuterol Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Gastrointestinal Agents Phase 4,Phase 1
23 Neuroprotective Agents Phase 4,Phase 1
24 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Tocolytic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
31 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3,Phase 1
32 Prednisolone phosphate Phase 4,Phase 2,Phase 3,Phase 1
33 Antiemetics Phase 4,Phase 1
34 Protective Agents Phase 4,Phase 1
35 Leukotriene Antagonists Phase 4,Phase 2,Phase 3,Not Applicable
36 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
38 Bronchodilator Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
39 Antineoplastic Agents, Hormonal Phase 4,Phase 1
40 Adrenergic alpha-Agonists Phase 4,Phase 1,Phase 2
41 Mydriatics Phase 4,Phase 1,Phase 2
42 Anti-Allergic Agents Phase 4
43 Vasoconstrictor Agents Phase 4,Phase 1,Phase 2
44 Epinephryl borate Phase 4,Phase 1,Phase 2,Not Applicable
45 Pharmaceutical Solutions Phase 4,Not Applicable
46 Dexamethasone acetate Phase 4,Phase 1 1177-87-3
47 BB 1101 Phase 4,Phase 1
48 Anti-Infective Agents Phase 4
49 Anti-Infective Agents, Local Phase 4
50 Benzalkonium Compounds Phase 4

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
2 Trial of Terbutaline for the Treatment of Status Asthmaticus in Children Completed NCT00124995 Phase 4 terbutaline
3 Continuous Levalbuterol for Treatment of Status Asthmaticus in Children Completed NCT00124176 Phase 4 Racemic albuterol (R+S albuterol);Levalbuterol (R albuterol)
4 Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma Completed NCT01333800 Phase 4 Beclomethasone;Ciclesonide
5 Acute Montelukast in Asthma Completed NCT01011452 Phase 4 Montelukast;Placebo
6 Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients Completed NCT00627731 Phase 4 methylprednisolone sodium succinate (mPSL);prednisolone (PSL)
7 Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation Completed NCT01705964 Phase 4 IM epinephrine 1:1000
8 Status Asthmaticus on the PICU; Intravenous Salbutamol Recruiting NCT03493503 Phase 4 Salbutamol;Sodium Chloride 0.9%
9 Comparison of Albuterol for Status Asthmaticus Not yet recruiting NCT02966184 Phase 4 preservative free albuterol
10 Steroids in Children Hospitalized With Asthma Terminated NCT02780479 Phase 4 Dexamethasone;Prednisone
11 Montelukast With Status Asthmaticus, Ages 6-18 Unknown status NCT00494572 Phase 2, Phase 3 Montelukast
12 Montelukast With Status Asthmaticus, Ages 2-5 Unknown status NCT00491790 Phase 2, Phase 3 Montelukast
13 Non Invasive Ventilation in Acute Asthma Unknown status NCT00510991 Phase 3
14 The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room Completed NCT01524198 Phase 2, Phase 3 Budesonide;Normal saline
15 Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
16 Fish Oil Supplementation During Pregnancy for Prevention of Asthma, Eczema and Allergies in Childhood Active, not recruiting NCT00798226 Phase 3
17 Vitamin D Supplementation During Pregnancy for Prevention of Asthma in Childhood Active, not recruiting NCT00856947 Phase 2, Phase 3
18 The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus Not yet recruiting NCT03338205 Phase 3 Ketamine
19 Nebulized Magnesium Sulfate in Pediatric Asthma Terminated NCT00522444 Phase 3 Nebulized Magnesium Sulfate
20 Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations Not yet recruiting NCT03277170 Phase 2 Montelukast Oral Granules
21 Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation Terminated NCT00410150 Phase 2 Helium-oxygen-driven albuterol nebulizer;Oxygen
22 Study Evaluating the Safety and Effects of MN-221 in Subjects Experiencing an Acute Exacerbation of Asthma Terminated NCT00683449 Phase 2 Dose Group 1;MN-221 placebo;Dose Group 2;Dose Group 3
23 Randomized, Placebo/Active Crossover Dose-ranging Study for Safety and Efficacy in Asthma Patients. Terminated NCT01025648 Phase 1, Phase 2 E004 (epinephrine inhalation aerosol), 90 mcg/actuation;E004 Placebo;E004 (epinephrine inhalation aerosol), 125 mcg;E004 (epinephrine inhalation aerosol), 220 mcg;epinephrine inhalation aerosol, CFC propelled;E004 (epinephrine inhalation aerosol), 160 mcg
24 Non Invasive Positive Pressure Ventilation in Status Asthmaticus Withdrawn NCT01403428 Phase 2
25 Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus Recruiting NCT02872597 Phase 1 Ipratropium;0.9% Sodium Chloride;Albuterol;corticosteroids
26 Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus Withdrawn NCT01188473 Phase 1
27 Evaluation Montelukast in the Treatment of Status Asthmaticus Unknown status NCT01770899 Not Applicable Montelukast;Placebo
28 Intravenous Terbutaline in Severe Status Asthmaticus Unknown status NCT00750568
29 Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children Unknown status NCT02112305 Not Applicable isotonic magnesium sulphate;50% magnesium sulphate
30 A Real Life Evaluation of the Performance of a Large Volume Nebulizer Unknown status NCT00632112
31 Mechanisms of Exacerbation of Asthma Unknown status NCT00594750
32 Pleth Variability and Asthma Severity in Children Completed NCT02302261
33 B2-Adrenergic Receptor Polymorphisms Completed NCT00279786
34 Effectiveness and Cost Study Comparing Two Ways to Deliver Albuterol for the Treatment of Asthma in the Hospital Completed NCT00623688 Not Applicable
35 HFCWO in Hospitalized Asthmatic Children Completed NCT00722020 Not Applicable
36 Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma Completed NCT01227070
37 Lung Function Changes of Induced Asthma Children Treated With Inhaled MgSO4 Completed NCT01856959 Not Applicable Magnesium Sulfate;magnesium sulfate & albuterol;Albuterol
38 Status Asthmaticus on the Intensive Care Prospective - STATIC PRO Recruiting NCT02936778
39 Effectiveness of the Aeroneb in Acute Severe Asthma Recruiting NCT03029156 Not Applicable
40 Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT) Recruiting NCT02880930 Not Applicable
41 NiPPV in the Treatment of Acute Asthma Exacerbations Active, not recruiting NCT03219736 Not Applicable
42 Cohort Analysis of Clinical and Biological Severe Childhood Asthma Active, not recruiting NCT02114034
43 High Flow Nasal Cannula in Children With Status Asthmaticus Not yet recruiting NCT03157102 Not Applicable
44 Use of High Frequency Chest Compression in Pediatric Status Asthmaticus Terminated NCT00552448 Not Applicable
45 A Prospective Trial of BiPAP Administration vs. Non-positive Pressure Therapy for Pediatric Status Asthmaticus Withdrawn NCT02539420 Not Applicable
46 Bilevel Positive Airway Pressure (BiPAP) for the Treatment of Moderate to Severe Acute Asthma Exacerbations Withdrawn NCT02347462 Not Applicable

Search NIH Clinical Center for Status Asthmaticus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: status asthmaticus

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Genetic Tests for Status Asthmaticus

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Anatomical Context for Status Asthmaticus

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MalaCards organs/tissues related to Status Asthmaticus:

41
Lung, Bone, Neutrophil, Testes, Brain
Sources

Publications for Status Asthmaticus

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Articles related to Status Asthmaticus:

(show top 50) (show all 535)
# Title Authors Year
1
Effects of a PICU Status Asthmaticus De-Escalation Pathway on Length of Stay and Albuterol Use. ( 29664873 )
2018
2
The effectiveness of magnesium sulfate for status asthmaticus outside the intensive care setting. ( 29660840 )
2018
3
Early Administration of Venovenous Extracorporeal Life Support for Status Asthmaticus during Anaesthetic Induction: Case Report and Literature Review. ( 29577091 )
2018
4
Characteristics and outcomes of treatment in status asthmaticus patients at emergency department. ( 29888929 )
2018
5
Extracorporeal membrane oxygenation (ECMO) and ultraprotective mechanical ventilation for near-fatal status asthmaticus. ( 28927779 )
2017
6
An Unusual Complication With the Administration of a Volatile Anesthetic Agent for Status Asthmaticus in the Pediatric Intensive Care Unit: Case Report and Review of the Literature. ( 28612677 )
2017
7
Nasal high flow in management of children with status asthmaticus: a retrospective observational study. ( 28534235 )
2017
8
Non-invasive ventilation use in status asthmaticus: 16a88years of experience in a tertiary intensive care. ( 29131536 )
2017
9
Management of status asthmaticus in children. ( 28137226 )
2017
10
A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus. ( 28555168 )
2017
11
Status Asthmaticus and Central Herniation: A Case for Multidisciplinary Critical Care. ( 28328592 )
2017
12
Adjunct Therapies for Refractory Status Asthmaticus in Children. ( 28546381 )
2017
13
High variability of treatments for paediatric status asthmaticus: a retrospective study in PICUs. ( 28634664 )
2017
14
Adjunctive extracorporeal carbon dioxide removal in refractory status asthmaticus. ( 28754757 )
2017
15
Allocating Staff-Intensive Therapies in Pediatric Status Asthmaticus. ( 27292859 )
2016
16
Anti-inflammatory dosing of theophylline in the treatment of status asthmaticus in children. ( 27785078 )
2016
17
Severe subcutaneous emphysema and pneumomediastinum secondary to noninvasive ventilation support in status asthmaticus. ( 27303140 )
2016
18
Idiopathic Hemothorax in a Patient with Status Asthmaticus. ( 27042969 )
2016
19
Status asthmaticus with pseudo-dextrocardia, complicated by iatrogenic tension pneumothorax. ( 27583095 )
2016
20
ECMO for intractable status asthmaticus following atracurium. ( 27933398 )
2016
21
The use of life-saving extracorporeal membrane oxygenation (ECMO) for pregnant woman with status asthmaticus. ( 27340744 )
2016
22
To: Heliox in the treatment of status asthmaticus: case reports. ( 27737430 )
2016
23
Potential factors involved in the causation of rhabdomyolysis following status asthmaticus. ( 27555875 )
2016
24
Comparison of Two High-Dose Magnesium Infusion Regimens in the Treatment of Status Asthmaticus. ( 27453701 )
2016
25
Reply to: Heliox in the treatment of status asthmaticus: case reports. ( 27737414 )
2016
26
Extracorporeal membrane oxygenation support for life-threatening acute severe status asthmaticus. ( 27758969 )
2016
27
Heliox in the treatment of status asthmaticus: case reports. ( 27096682 )
2016
28
Impact of Obesity on Clinical Outcomes in Urban Children Hospitalized for Status Asthmaticus. ( 27012614 )
2016
29
Sevoflurane administration initiated out of the ED for life-threatening status asthmaticus. ( 25662208 )
2015
30
1291: EARLY VENOVENOUS ECMO FOR REFRACTORY STATUS ASTHMATICUS IN A PEDIATRIC ADOLESCENT. ( 26570951 )
2015
31
Effect of high-dose continuous albuterol nebulization on clinical variables in children with status asthmaticus. ( 25560428 )
2015
32
Volatile anesthetics for status asthmaticus in pediatric patients: a comprehensive review and case series. ( 25580870 )
2015
33
Accelerated Idioventricular Rhythm in a Child With Status Asthmaticus. ( 26169431 )
2015
34
An Asthma Protocol Improved Adherence to Evidence-Based Guidelines for Pediatric Subjects With Status Asthmaticus in the Emergency Department. ( 26106203 )
2015
35
524: SLEEP EEG CHARACTERISTICS OF CRITICALLY ILL CHILDREN WITH STATUS ASTHMATICUS. ( 26570185 )
2015
36
Noninvasive ventilation in status asthmaticus in children: levels of evidence. ( 26761478 )
2015
37
1256: ARTERIOVENOUS CO2 REMOVAL (AVCO2R) IN A POST-PARTUM PATIENT WITH REFRACTORY STATUS ASTHMATICUS. ( 26570917 )
2015
38
Aminophylline infusion for status asthmaticus in the pediatric critical care unit setting is independently associated with increased length of stay and time for symptom improvement. ( 23523660 )
2014
39
Ketamine for Status Asthmaticus with Respiratory Failure. ( 25216536 )
2014
40
Extracorporeal carbon dioxide removal for refractory status asthmaticus: experience in distinct exacerbation phenotypes. ( 23842616 )
2014
41
Outcomes of invasive mechanical ventilation in children and adolescents hospitalized due to status asthmaticus in United States: a population based study. ( 25295383 )
2014
42
Transient intrapulmonary shunting in a patient treated with I^a88-adrenergic agonists for status asthmaticus. ( 24639274 )
2014
43
Emergency treatment of status asthmaticus with enoximone. ( 24638233 )
2014
44
Clinical course and outcome of acute severe asthma (status asthmaticus) in adults. ( 25831649 )
2014
45
Cesarean delivery for refractory status asthmaticus. ( 23344394 )
2013
46
Just a lot of hot air? Volatile anesthetics in children with status asthmaticus. ( 23648873 )
2013
47
Tracheobronchial mycosis in a retrospective case-series study of five status asthmaticus patients. ( 23280490 )
2013
48
High-dose magnesium sulfate infusion protocol for status asthmaticus: a safety and pharmacokinetics cohort study. ( 23129148 )
2013
49
Pediatric status asthmaticus. ( 23537669 )
2013
50
Extracorporeal membrane oxygenation is indicated for status asthmaticus refractory to maximal conventional therapy. ( 23535097 )
2013
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Variations for Status Asthmaticus

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Expression for Status Asthmaticus

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Search GEO for disease gene expression data for Status Asthmaticus.
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Pathways for Status Asthmaticus

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Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 11.89 CCL5 CCL7 CXCL8
2
IL-17 Family Signaling Pathways 65
Show member pathways
 11.83 CCL7 CXCL8 IL5
3
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 65
Show member pathways
 11.4 CCL5 CCL7 CXCL8
4
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.27 CCL5 CCL7 CXCL8 IL5
5
Interleukin-10 signaling 66
11.12 CCL5 CXCL8
6
Cell adhesion_Cell-matrix glycoconjugates 22
11 CCL5 ELANE
7
EBV LMP1 signaling 1
10.64 CCL5 CXCL8
8
Lung fibrosis 1
10.6 CCL5 CXCL8 IL5
Sources

GO Terms for Status Asthmaticus

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Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL5 CCL7 CXCL8 ELANE IL5 RNASE3
2 extracellular space GO:0005615 9.1 CCL5 CCL7 CXCL8 ELANE IL5 RNASE3

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CCL5 CCL7 CXCL8 IL5
2 cell-cell signaling GO:0007267 9.76 ADRB2 CCL5 CCL7
3 regulation of signaling receptor activity GO:0010469 9.76 CCL5 CCL7 CXCL8 IL5
4 cytokine-mediated signaling pathway GO:0019221 9.75 CCL5 CXCL8 IL5
5 chemotaxis GO:0006935 9.69 CCL5 CCL7 CXCL8
6 inflammatory response GO:0006954 9.67 CCL5 CCL7 CXCL8 IL5
7 cellular response to tumor necrosis factor GO:0071356 9.65 CCL5 CCL7 CXCL8
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.6 CCL5 ELANE
9 antimicrobial humoral response GO:0019730 9.59 ELANE RNASE3
10 monocyte chemotaxis GO:0002548 9.57 CCL5 CCL7
11 lymphocyte chemotaxis GO:0048247 9.56 CCL5 CCL7
12 cellular response to fibroblast growth factor stimulus GO:0044344 9.55 CCL5 CXCL8
13 positive regulation of JAK-STAT cascade GO:0046427 9.54 CCL5 IL5
14 eosinophil chemotaxis GO:0048245 9.52 CCL5 CCL7
15 cellular calcium ion homeostasis GO:0006874 9.5 CCL5 CCL7 ELANE
16 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.43 CCL5 CXCL8
17 cellular response to interleukin-1 GO:0071347 9.43 CCL5 CCL7 CXCL8
18 neutrophil activation GO:0042119 9.4 CCL5 CXCL8
19 positive regulation of natural killer cell chemotaxis GO:2000503 9.16 CCL5 CCL7
20 chemokine-mediated signaling pathway GO:0070098 9.13 CCL5 CCL7 CXCL8
21 neutrophil chemotaxis GO:0030593 8.8 CCL5 CCL7 CXCL8

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.26 CCL5 CCL7
2 CCR1 chemokine receptor binding GO:0031726 9.16 CCL5 CCL7
3 chemokine activity GO:0008009 9.13 CCL5 CCL7 CXCL8
4 cytokine activity GO:0005125 8.92 CCL5 CCL7 CXCL8 IL5
Sources

Sources for Status Asthmaticus

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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