Status Asthmaticus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: STT002 MIFTS: 49	Status Asthmaticus Categories: Respiratory diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Status Asthmaticus

MalaCards integrated aliases for Status Asthmaticus:

Name: Status Asthmaticus ¹² ⁵⁴ ⁴⁴ ¹⁵ ¹⁷ ⁷⁰ ³²

Asthma with Status Asthmaticus ¹²

Severe Asthma Attack ¹²

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the respiratory system

Chronic lower respiratory diseases

Status asthmaticus

External Ids:

Disease Ontology ¹² DOID:9362

ICD9CM ³⁴ 493.91

MeSH ⁴⁴ D013224

NCIt ⁵⁰ C122577

SNOMED-CT ⁶⁷ 36979006

ICD10 ³² J46

EFO ¹⁷ EFO_0008590

UMLS ⁷⁰ C0038218

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Summaries for Status Asthmaticus

Disease Ontology : ¹² An acute asthma that is characterized by an acute episode with a progressive severity that is poorly responsive to standard therapeutic measures, regardless of disease severity or phenotypic variant.

MalaCards based summary : Status Asthmaticus, also known as asthma with status asthmaticus, is related to acute asthma and allergic asthma. An important gene associated with Status Asthmaticus is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : ⁷³ Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not... more...

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Related Diseases for Status Asthmaticus

Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)

#	Related Disease	Score	Top Affiliating Genes
1	acute asthma	31.4	RNASE3 IL5 ADRB2
2	allergic asthma	31.3	RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
3	chronic asthma	30.9	RNASE3 IL5 CCL11
4	near-fatal asthma	30.8	CCL5 ADRB2
5	ige responsiveness, atopic	30.3	RNASE3 IL5 IL10
6	bacterial pneumonia	30.2	IL10 ELANE CXCL8
7	enterocolitis	30.2	IL10 CXCL8
8	bronchopneumonia	30.0	IL10 ELANE CXCL8
9	pulmonary emphysema	29.9	MMP9 ELANE CXCL8
10	duodenal ulcer	29.8	IL1RN IL10 CXCL8
11	alpha-1-antitrypsin deficiency	29.8	MMP3 ELANE CXCL8
12	pertussis	29.7	IL10 CXCL8 CCL5 CCL11
13	esophagitis	29.6	RNASE3 IL5 IL10 CXCL8 CCL11
14	hypereosinophilic syndrome	29.6	RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
15	allergic rhinitis	29.6	RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
16	pre-eclampsia	29.5	MMP9 IL10 CXCL8 ADRB2
17	otitis media	29.4	RNASE3 MUC5AC IL5 IL10 CXCL8 CCL11
18	dermatitis	29.4	RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
19	neutropenia	29.3	IL1RN IL10 ELANE CXCL8
20	adult respiratory distress syndrome	29.3	IL1RN IL1R1 IL10 ELANE CXCL8 ADRB2
21	gastritis	29.3	IL1RN IL10 CXCL8 CCL5
22	cerebral palsy	29.2	MMP3 IL10 CXCL8 CCL7 ADRB2
23	bronchitis	29.2	RNASE3 MMP9 IL5 IL10 ELANE CXCL8
24	rhinitis	29.2	RNASE3 IL5 IL10 CXCL8 CCL7 CCL5
25	body mass index quantitative trait locus 11	29.0	MMP3 IL10 CXCL8 CCL5 CCL11 ADRB2
26	thrombocytopenia	28.9	PIK3C2A MMP9 IL1RN IL10 CXCL8
27	asthma	28.8	RNASE3 MUC5AC MMP9 IL5 IL1RN IL1R1
28	respiratory failure	28.8	RNASE3 PIK3C2A MUC5AC IL5 IL1RN IL1R1
29	lung disease	28.5	RNASE3 MUC5AC MMP9 IL5 IL10 ELANE
30	proteasome-associated autoinflammatory syndrome 1	27.8	RNASE3 MMP9 IL5 IL1RN IL1R1 IL10
31	myopathy	10.6
32	pneumothorax	10.5
33	metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration	10.4
34	encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	10.4
35	pemphigoid	10.4	IL5 CCL11
36	metabolic acidosis	10.4
37	loeffler endocarditis	10.4	RNASE3 IL5
38	perinephritis	10.3	PIK3C2A ADRB2
39	cough variant asthma	10.3	RNASE3 IL5
40	eosinophilic gastritis	10.3	IL5 CCL11
41	myoglobinuria	10.3
42	quadriplegia	10.3
43	respiratory syncytial virus infectious disease	10.3	IL5 CCL5
44	disseminated eosinophilic collagen disease	10.3	RNASE3 IL5
45	kimura disease	10.3	RNASE3 IL5
46	vernal conjunctivitis	10.3	RNASE3 MUC5AC
47	adhesive otitis media	10.3	RNASE3 CCL11
48	ceftriaxone allergy	10.3	IL5 IL10
49	lung mucoepidermoid carcinoma	10.3	MUC5AC CXCL8
50	eustachian tube disease	10.3	RNASE3 CCL11

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 13)

Anxiety	Asthma
Bronchitis	Chronic Maxillary Sinusitis
Chronic Pulmonary Heart Disease	Conn's Syndrome
Esophagitis	Heart Disease
Hypertension, Essential	Hypothyroidism
Oral Candidiasis	Osteoporosis
Respiratory Failure

Graphical network of the top 20 diseases related to Status Asthmaticus:

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Symptoms & Phenotypes for Status Asthmaticus

MGI Mouse Phenotypes related to Status Asthmaticus:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.7	ADRB2 CCL11 CCL5 ELANE IL10 IL1R1
2	immune system	MP:0005387	9.4	ADRB2 CCL11 CCL5 ELANE IL10 IL1R1

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Drugs & Therapeutics for Status Asthmaticus

Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dexamethasone

Approved, Investigational, Vet_approved

Phase 4

50-02-2

5743

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

6741

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 4

1177-87-3

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

5755

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

Formoterol Fumarate

Phase 4

Beclomethasone

Phase 4

4419-39-0

20469

Sympathomimetics

Phase 4

Respiratory System Agents

Phase 4

Anti-Asthmatic Agents

Phase 4

Adrenergic beta-Agonists

Phase 4

Adrenergic Agents

Phase 4

Adrenergic Agonists

Phase 4

Tocolytic Agents

Phase 4

Neurotransmitter Agents

Phase 4

Bronchodilator Agents

Phase 4

Pharmaceutical Solutions

Phase 4

Hormone Antagonists

Phase 4

Hormones

Phase 4

Gastrointestinal Agents

Phase 4

Antiemetics

Phase 4

Methylprednisolone Acetate

Phase 4

Anti-Inflammatory Agents

Phase 4

glucocorticoids

Phase 4

Antineoplastic Agents, Hormonal

Phase 4

BB 1101

Phase 4

Montelukast

Approved

Phase 2, Phase 3

158966-92-8

5281040

Ketamine

Approved, Vet_approved

Phase 3

6740-88-1

3821

Leukotriene Antagonists

Phase 2, Phase 3

Anesthetics, General

Phase 3

Anesthetics, Dissociative

Phase 3

Anesthetics

Phase 3

Excitatory Amino Acid Antagonists

Phase 3

Anesthetics, Intravenous

Phase 3

Analgesics

Phase 3

Benralizumab

Approved, Investigational

Phase 2

1044511-01-4

Immunoglobulins

Phase 2

Antibodies

Phase 2

Antibodies, Monoclonal

Phase 2

Budesonide

Approved

Phase 1

51333-22-3

63006 5281004

Hydrocortisone

Approved, Vet_approved

Phase 1

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 1

50-03-3

Cholinergic Agents

Phase 1

Cholinergic Antagonists

Phase 1

Neuroprotective Agents

Phase 1

Protective Agents

Phase 1

Interventional clinical trials:

(show all 36)

#	Name	Status	NCT ID	Phase	Drugs
1	Extra-fine Formoterol/Beclomethasone in the Treatment of Asthmatic Crisis	Unknown status	NCT02345993	Phase 4	Extra fine Formoterol/Beclomethasone
2	Efficacy of a Loading Dose of IV Salbutamol in Children Admitted to a PICU for Severe Acute Asthma or Severe Acute Wheeze	Completed	NCT03493503	Phase 4	Salbutamol;Sodium Chloride 0.9%
3	Double-blinded Randomized Trial of Terbutaline to Shorten ICU Length of Stay in the Treatment of Status Asthmaticus in Children	Completed	NCT00124995	Phase 4	terbutaline
4	Continuous Levalbuterol for Treatment of Status Asthmaticus in Children	Completed	NCT00124176	Phase 4	Racemic albuterol (R+S albuterol);Levalbuterol (R albuterol)
5	Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit	Enrolling by invitation	NCT03900624	Phase 4	Dexamethasone
6	Comparison of Benzalkonium Chloride Containing Albuterol Versus Preservative Free Albuterol for the Treatment of Status Asthmaticus	Suspended	NCT02966184	Phase 4	preservative free albuterol
7	Oral Dexamethasone Versus Oral Prednisone in Children Hospitalized With Asthma: A Randomized Control Study	Terminated	NCT02780479	Phase 4	Dexamethasone;Prednisone
8	Montelukast With Status Asthmaticus, Ages 2-5	Unknown status	NCT00491790	Phase 2, Phase 3	Montelukast
9	Pharmacokinetics and Pharmacodynamics of Montelukast in Children, Ages 6 Through 18 Years Old, With Status Asthmaticus Unresponsive to Conventional Treatment	Unknown status	NCT00494572	Phase 2, Phase 3	Montelukast
10	The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room	Completed	NCT01524198	Phase 2, Phase 3	Budesonide;Normal saline
11	The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study	Not yet recruiting	NCT03338205	Phase 3	Ketamine
12	Randomized Double Blind Placebo Controlled Trial of Benralizumab, an Antiinterleukin 5 Receptor α Monoclonal Antibody, Initiated During Hospitalization for Severe Asthma Attack in Reducing Severe Exacerbations: Phase 2B Study	Not yet recruiting	NCT04617171	Phase 2	Benralizumab 30 MG/ML [Fasenra];Placebos
13	A Phase II, Randomized, Modified Single-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of MN-221 When Administered Intravenously as an Adjunct to Standard Therapy to Adults With an Acute Exacerbation of Asthma	Terminated	NCT00683449	Phase 2	Dose Group 1;MN-221 placebo;Dose Group 2;Dose Group 3
14	A Prospective, Randomized, Controlled, Single Center Trial of the Use of Heliox in Children Admitted to the Hospital With Status Asthmaticus	Terminated	NCT00410150	Phase 2	Helium-oxygen-driven albuterol nebulizer;Oxygen
15	Effect Of Early Initiation Of Noninvasive Positive Pressure Ventilation On ICU Length Of Stay In Children With Status Asthmaticus, A Prospective Randomized Trial	Withdrawn	NCT01403428	Phase 2
16	High Fidelity Simulation (HFS) Versus Video-case(VC) Trainings in the Assessement and Management of Severe Asthma Attack Among Medical School Students: a Randomized Controlled Study	Completed	NCT02776358	Phase 1
17	A Phase I, Single Center, Placebo-Controlled, Blinded Pilot Study of Ipratropium Bromide in Children Admitted to the Intensive Care Unit With Status Asthmaticus	Completed	NCT02872597	Phase 1	Ipratropium;0.9% Sodium Chloride;Albuterol;corticosteroids
18	Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Managed in the Emergency Department: A Randomized Controlled Trial	Recruiting	NCT04016220	Phase 1	Budesonide;normal saline
19	Safety and Efficacy of Early Initiation of Noninvasive Positive Pressure Ventilation in Pediatric Patients Admitted With Status Asthmaticus	Withdrawn	NCT01188473	Phase 1
20	A Prospective Analysis of the Use of Oral Montelukast in Children With Status Asthmaticus	Unknown status	NCT01770899		Montelukast;Placebo
21	Pharmacokinetics and Pharmacodynamics of Terbutaline Given as a Continuous Intravenous Infusion in Severe Status Asthmaticus	Unknown status	NCT00750568
22	Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma	Unknown status	NCT02112305		isotonic magnesium sulphate;50% magnesium sulphate
23	Risk Factors for Intensive Care Admission of Children With Severe Acute Wheeze or Asthma (SAA)	Completed	NCT02936778
24	High Frequency Chest Wall Oscillation in Hospital Management of Asthmatic Children	Completed	NCT00722020
25	Effectiveness and Costs of Albuterol Delivered by MDI With Spacer Versus Nebulizer in Children Hospitalized With Moderate and Severe Asthma Exacerbations	Completed	NCT00623688
26	Using Pleth Variability to Triage Asthmatics in the Pediatric ED	Completed	NCT02302261
27	B2-Adrenergic Receptor Polymorphisms: Implications For The Treatment Of Status Asthmaticus In Children	Completed	NCT00279786
28	Optimizing Vitamin D Status in Children With Pre-school Wheeze or Asthma:a Pilot Study (OPTIVIT)	Completed	NCT02880930
29	Effectiveness of the Aeroneb Compared to a Jet Nebulizer Fort the Delivery of Bronchodilator Therapy of Acute Severe Asthma	Completed	NCT03029156
30	High Flow Nasal Cannula Versus Standard Oxygen Therapy in Children With Status Asthmaticus: a Randomized Controlled Trial	Recruiting	NCT03157102
31	Pilot Randomized Control Trial of Telemedical Support for Paramedics in Simulated Pre-hospital Pediatric Emergencies	Enrolling by invitation	NCT03742167
32	Bilevel Positive Airway Pressure (BPAP) in Pediatric Asthma Exacerbations: A Pilot Study	Not yet recruiting	NCT04656587
33	Use of High Frequency Chest Compression (HFCC) in Pediatric Status Asthmaticus	Terminated	NCT00552448
34	A Prospective, Randomized Trial of Early Versus Delayed BiPAP Administration or Non-positive Pressure Therapy in the Management of Pediatric Status Asthmaticus	Withdrawn	NCT02539420
35	A Prospective Open Randomized Clinical Trial Comparing Bilevel Positive Airway Pressure (BiPAP) Therapy Against Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma Unresponsive to Inhaled Bronchodilators.	Withdrawn	NCT02347462
36	A Randomized Controlled Trial of Non-Invasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations	Withdrawn	NCT03219736

Search NIH Clinical Center for Status Asthmaticus

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :

Enflurane

ethyl ether

Halothane

Hydrocortisone

hydrocortisone acetate

HYDROCORTISONE ACETATE PWDR

HYDROCORTISONE ACETONIDE

Hydrocortisone butyrate

hydrocortisone cypionate

hydrocortisone probutate

HYDROCORTISONE PWDR

Hydrocortisone sodium phosphate

Hydrocortisone sodium succinate

hydrocortisone valerate

HYDROCORTISONE,NONSTERILE PWDR

Isoflurane

Cochrane evidence based reviews: status asthmaticus

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Genetic Tests for Status Asthmaticus

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Anatomical Context for Status Asthmaticus

MalaCards organs/tissues related to Status Asthmaticus:

⁴⁰

Heart, Lung, Eye, Bone, Brain, Kidney, Smooth Muscle

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Publications for Status Asthmaticus

Articles related to Status Asthmaticus:

(show top 50) (show all 1387)

#	Title	Authors	PMID	Year
1	Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. ⁵⁴ ⁶¹	Mehta R...Wheeler DS	16912630	2006
2	Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. ⁶¹ ⁵⁴	Elbahlawan L...Dahmer MK	16395068	2006
3	Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. ⁵⁴ ⁶¹	Binaei S...Quasney M	12628991	2003
4	Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study. ⁶¹	Ruman-Colombier M...Pauchard JY	33089387	2021
5	Point-of-Care Lung Ultrasound to Diagnose the Etiology of Acute Respiratory Failure at Admission to the PICU. ⁶¹	DeSanti RL...Kory PD	33739956	2021
6	High frequency percussive ventilation as a rescue mode for refractory status asthmaticus - a case study. ⁶¹	Albecker D...Franklin Lewis B	31668108	2021
7	Characterization of ketamine usage in a large tertiary-care emergency department. ⁶¹	McKinley K...Yousef D	33812331	2021
8	Difficulty Ventilating: A Case Report on Ventilation Considerations of an Intubated Asthmatic Undergoing Air Medical Critical Care Transport. ⁶¹	Cavaliere GA...Lawner BJ	33637279	2021
9	Implementation of a Critical Care Asthma Pathway in the PICU. ⁶¹	Miksa M...Katyal C	33604577	2021
10	Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus. ⁶¹	Ryan KS...Sochet AA	31608716	2021
11	Systemic glucocorticoid at discharge after hospitalization for pediatric asthma: a prospective pilot study. ⁶¹	Sharma S...Eby Halvorson E	33492180	2021
12	Comparison of Two Assessment Tools for Hospitalized Subjects With Asthma. ⁶¹	Schroeder SK...Nevin MA	32962997	2021
13	Salbutamol-induced lactic acidosis in status asthmaticus survivor. ⁶¹	Phoophiboon V...Sriprasart T	33435939	2021
14	High-flow nasal cannula and bilevel positive airway pressure for pediatric status asthmaticus: a single center, retrospective descriptive and comparative cohort study. ⁶¹	Russi BW...Sochet AA	33401990	2021
15	Extracorporeal Carbon Dioxide Removal in the Treatment of Status Asthmaticus. ⁶¹	Bromberger BJ...Sonett JR	33031151	2020
16	Emergency Department Airway Management for Status Asthmaticus With Respiratory Failure. ⁶¹	Godwin HT...Brown CA	32723860	2020
17	Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. ⁶¹	Dean PN...Lautz AJ	32896033	2020
18	Physiologically variable ventilation in a rabbit model of asthma exacerbation. ⁶¹	Dos Santos Rocha A...Habre W	33070949	2020
19	Burden of Asthma in Elderly Japanese Patients: Using Hospital-Based Administrative Claims Data. ⁶¹	Sato K...Kaise T	32504384	2020
20	Descriptions and outcomes of cardiac evaluations in pediatric patients hospitalized for asthma. ⁶¹	Parlar-Chun R...Singh M	31288567	2020
21	Greater length of stay and hospital charges for severe asthma in children with depression or anxiety. ⁶¹	Munoz FA...Seckeler MD	32902930	2020
22	Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. ⁶¹	Bradford LE...Loughlin CE	31352844	2020
23	Comparison of two continuous nebulized albuterol doses in critically ill children with status asthmaticus. ⁶¹	Lin AT...Karsies TJ	31119958	2020
24	Bilevel Positive Airway Pressure ventilation efficiently improves respiratory distress in initial hours treating children with severe asthma exacerbation. ⁶¹	Kang CM...Yen TA	31806384	2020
25	A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency. ⁶¹	Sofian ZM...Jones SA	33043128	2020
26	Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding. ⁶¹	Sochet AA...Nakagawa TA	31046509	2020
27	Unsuspected foreign-body aspiration in adult patient with status asthmaticus: Case report. ⁶¹	Fernandez-Trujillo L...Bautista DF	32551105	2020
28	Terbutaline and aminophylline as second-line therapies for status asthmaticus in the pediatric intensive care unit. ⁶¹	Stulce C...Kane JM	32426910	2020
29	Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017. ⁶¹	Mittal V...Shah SS	32584247	2020
30	Usefulness of extracorporeal membrane oxygenation in status asthmaticus with severe tracheal stenosis. ⁶¹	Odigwe C...Arya RR	32675965	2020
31	Improving the Pediatric Emergency Department Learning Experience: A Simulation-Based Orientation for Pediatric PGY 1 Residents. ⁶¹	Holzemer NF...Tomlinson S	32656335	2020
32	Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children. ⁶¹	Medar SS...Rastogi D	32227683	2020
33	The Reemergence of Ketamine for Treatment in Critically Ill Adults. ⁶¹	Hurth KP...Wohlfarth KM	32317593	2020
34	Pediatric Boot Camp Series: Longitudinal Care for a Child With Asthma-From the Emergency Department to Outpatient Clinic. ⁶¹	Metz J...Burns R	32656327	2020
35	Asthma deaths in North Carolina: 1999-2016. ⁶¹	Kearney GD...O'Brien K	30810458	2020
36	Outcome of status asthmaticus at a pediatric intensive care unit in Hong Kong. ⁶¹	Cheng WT...Qian SY	31965725	2020
37	SCAMP-ering Toward Improved Quality of Care in Children With Status Asthmaticus. ⁶¹	Carroll CL	32358332	2020
38	Standardized Protocol Is Associated With a Decrease in Continuous Albuterol Use and Length of Stay in Critical Status Asthmaticus. ⁶¹	Melendez E...Wong J	32084098	2020
39	Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study. ⁶¹	Oddone F...VISIONARY Study Group	32072493	2020
40	Status asthmaticus requiring extracorporeal membrane oxygenation associated with rhinovirus infection. ⁶¹	Greenawald L...Chidekel A	30882258	2020
41	Improving Influenza Vaccination in Hospitalized Children With Asthma. ⁶¹	Foradori DM...Lo HY	32107285	2020
42	Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study. ⁶¹	Shi P...Huang G	32164622	2020
43	Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options. ⁶¹	Ramirez IA...Arteta M	31986238	2020
44	Association of various weight-based doses of continuous albuterol on hospital length of stay. ⁶¹	Parlar-Chun R...Arnold K	31994959	2020
45	A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature. ⁶¹	Medar SS...Peek GJ	31860773	2020
46	Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus. ⁶¹	Vet NJ...de Hoog M	31432470	2020
47	Enoximone in status asthmaticus. ⁶¹	Schulz O...Busch M	32280667	2020
48	Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation. ⁶¹	LaGrew JE...Frantz A	31948977	2020
49	Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report. ⁶¹	De Rosa S...Ronco C	32042585	2020
50	High-frequency oscillatory ventilation as a rescue for severe asthma crisis in a child. ⁶¹	Sharma K...Vidal R	32974029	2020

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Genes for Status Asthmaticus

Genes related to Status Asthmaticus (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	19.23	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16912630
2	ADRB2	Adrenoceptor Beta 2	Protein Coding	18.82	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	16395068 12628991
3	IL5	Interleukin 5	Protein Coding	13.3	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	12.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	RNASE3	Ribonuclease A Family Member 3	Protein Coding	12.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	12.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	11.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	ELANE	Elastase, Neutrophil Expressed	Protein Coding	11.94	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	11.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	IL10	Interleukin 10	Protein Coding	11.47	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	CCL7	C-C Motif Chemokine Ligand 7	Protein Coding	10.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	MMP9	Matrix Metallopeptidase 9	Protein Coding	10.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	MMP3	Matrix Metallopeptidase 3	Protein Coding	10.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	10.07	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	10	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

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Variations for Status Asthmaticus

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Expression for Status Asthmaticus

Search GEO for disease gene expression data for Status Asthmaticus.

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Pathways for Status Asthmaticus

Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.78	RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.53	IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
3	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.4	IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.23	IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.09	IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.08	MMP9 MMP3 IL5 IL1RN IL1R1 IL10
7	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.72	RNASE3 IL5 IL10 CXCL8 CCL11
8	Immune response CCR3 signaling in eosinophils ²³ Show member pathways Inhibitory action of Lipoxins on neutrophil migration ²³	12.22	CXCL8 CCL7 CCL5 CCL11
9	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.17	IL10 CXCL8 CCL7 CCL5 CCL11
10	Transcriptional misregulation in cancer ³⁶	12.11	MMP9 MMP3 ELANE CXCL8
11	IL-1 Family Signaling Pathways ⁶⁴ Show member pathways Immune response IL-1 signaling pathway ²³ Mucin expression in CF via TLRs, EGFR signaling pathways ²³	12.06	MUC5AC IL1RN IL1R1 CXCL8
12	MAPK Pathway ⁶⁹ Show member pathways Toll-like Receptor Pathway ⁶⁹	11.91	PIK3C2A IL5 IL1R1
13	Spinal Cord Injury ¹	11.89	MMP9 IL1R1 CXCL8
14	TNF signaling pathway ³⁶	11.85	MMP9 MMP3 CCL5
15	Amoebiasis ³⁶	11.8	IL1R1 IL10 CXCL8
16	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁵ Inhibition of Matrix Metalloproteinases ⁶³	11.78	MMP9 MMP3 ELANE
17	Rheumatoid arthritis ³⁶	11.75	MMP3 CXCL8 CCL5
18	Interleukin-4 and 13 signaling ⁶⁵	11.71	MMP9 MMP3 IL10 CXCL8 CCL11
19	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.68	IL5 IL1R1 IL10
20	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.54	MMP9 MMP3 CXCL8
21	IL4-mediated signaling events ¹	11.53	IL5 IL10 CCL11
22	Cell adhesion_ECM remodeling ²³	11.51	MMP9 MMP3 CXCL8
23	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	11.5	MUC5AC MMP9 MMP3 IL5 CXCL8 CCL7
24	Lung fibrosis ¹	11.35	MMP9 IL5 CXCL8 CCL5 CCL11
25	Th2 Differentiation Pathway ⁶⁴	11.33	IL5 IL10 CCL11
26	Cell adhesion_Cell-matrix glycoconjugates ²³	11.26	MMP9 MMP3 ELANE CCL5
27	Interleukin-10 signaling ⁶⁵	11.04	IL1RN IL1R1 IL10 CXCL8 CCL5
28	Syndecan-1-mediated signaling events ¹	10.87	MMP9 CCL5
29	G-protein signaling_Rap2B regulation pathway ²³	10.84	IL5 IL10 CXCL8 CCL7 CCL5 CCL11

Sources

GO Terms for Status Asthmaticus

Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.73	RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN
2	extracellular region	GO:0005576	9.44	RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 27)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.13	IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
2	positive regulation of cell migration	GO:0030335	9.88	MMP9 CCL7 CCL5 CCL11
3	cellular response to tumor necrosis factor	GO:0071356	9.83	CXCL8 CCL7 CCL5 CCL11
4	cellular response to interferon-gamma	GO:0071346	9.79	CCL7 CCL5 CCL11
5	cellular calcium ion homeostasis	GO:0006874	9.76	ELANE CCL7 CCL5 CCL11
6	extracellular matrix disassembly	GO:0022617	9.74	MMP9 MMP3 ELANE
7	monocyte chemotaxis	GO:0002548	9.72	CCL7 CCL5 CCL11
8	cellular response to interleukin-1	GO:0071347	9.71	CXCL8 CCL7 CCL5 CCL11
9	inflammatory response	GO:0006954	9.7	IL5 IL1RN IL1R1 CXCL8 CCL7 CCL5
10	lymphocyte chemotaxis	GO:0048247	9.69	CCL7 CCL5 CCL11
11	positive regulation of JAK-STAT cascade	GO:0046427	9.67	IL5 IL10 CCL5
12	neutrophil chemotaxis	GO:0030593	9.67	CXCL8 CCL7 CCL5 CCL11
13	chemotaxis	GO:0006935	9.65	RNASE3 CXCL8 CCL7 CCL5 CCL11
14	positive regulation of immunoglobulin production	GO:0002639	9.63	IL5 IL10
15	response to amyloid-beta	GO:1904645	9.63	MMP9 MMP3
16	negative regulation of G protein-coupled receptor signaling pathway	GO:0045744	9.62	CXCL8 CCL5
17	neutrophil activation	GO:0042119	9.62	CXCL8 CCL5
18	chemokine-mediated signaling pathway	GO:0070098	9.62	CXCL8 CCL7 CCL5 CCL11
19	regulation of neuroinflammatory response	GO:0150077	9.61	MMP9 MMP3
20	eosinophil chemotaxis	GO:0048245	9.61	CCL7 CCL5 CCL11
21	cellular response to UV-A	GO:0071492	9.6	MMP9 MMP3
22	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.59	IL1RN IL10
23	response to molecule of bacterial origin	GO:0002237	9.58	IL10 CXCL8
24	positive regulation of natural killer cell chemotaxis	GO:2000503	9.56	CCL7 CCL5
25	immune response	GO:0006955	9.56	IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
26	positive regulation of cellular biosynthetic process	GO:0031328	9.54	CXCL8 CCL5
27	cytokine-mediated signaling pathway	GO:0019221	9.28	MMP9 MMP3 IL5 IL1RN IL1R1 IL10

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endopeptidase activity	GO:0004175	9.5	MMP9 MMP3 ELANE
2	CCR chemokine receptor binding	GO:0048020	9.33	CCL7 CCL5 CCL11
3	CCR1 chemokine receptor binding	GO:0031726	9.26	CCL7 CCL5
4	chemokine activity	GO:0008009	9.26	CXCL8 CCL7 CCL5 CCL11
5	cytokine activity	GO:0005125	9.17	IL5 IL1RN IL10 CXCL8 CCL7 CCL5

Sources

Sources for Status Asthmaticus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Status Asthmaticus

Aliases & Classifications for Status Asthmaticus

MalaCards integrated aliases for Status Asthmaticus:

Classifications:

External Ids:

Summaries for Status Asthmaticus

Related Diseases for Status Asthmaticus

Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 13)

Graphical network of the top 20 diseases related to Status Asthmaticus:

Symptoms & Phenotypes for Status Asthmaticus

MGI Mouse Phenotypes related to Status Asthmaticus:

Drugs & Therapeutics for Status Asthmaticus

Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Cochrane evidence based reviews: status asthmaticus

Genetic Tests for Status Asthmaticus

Anatomical Context for Status Asthmaticus

MalaCards organs/tissues related to Status Asthmaticus:

Publications for Status Asthmaticus

Articles related to Status Asthmaticus:

Genes for Status Asthmaticus

Genes related to Status Asthmaticus (0 elite genes):

Variations for Status Asthmaticus

Expression for Status Asthmaticus

Pathways for Status Asthmaticus

Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

GO Terms for Status Asthmaticus

Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

Sources for Status Asthmaticus

Inferred drug relations via UMLS ⁷⁰ / NDF-RT ⁵¹ :