Status Asthmaticus

Categories: Respiratory diseases

Aliases & Classifications for Status Asthmaticus

MalaCards integrated aliases for Status Asthmaticus:

Name: Status Asthmaticus 12 54 44 15 17 70 32
Asthma with Status Asthmaticus 12
Severe Asthma Attack 12


External Ids:

Disease Ontology 12 DOID:9362
ICD9CM 34 493.91
MeSH 44 D013224
NCIt 50 C122577
SNOMED-CT 67 36979006
ICD10 32 J46
UMLS 70 C0038218

Summaries for Status Asthmaticus

Disease Ontology : 12 An acute asthma that is characterized by an acute episode with a progressive severity that is poorly responsive to standard therapeutic measures, regardless of disease severity or phenotypic variant.

MalaCards based summary : Status Asthmaticus, also known as asthma with status asthmaticus, is related to acute asthma and allergic asthma. An important gene associated with Status Asthmaticus is PIK3C2A (Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Dexamethasone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and eye, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Acute severe asthma, also known as status asthmaticus, is an acute exacerbation of asthma that does not... more...

Related Diseases for Status Asthmaticus

Diseases related to Status Asthmaticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 376)
# Related Disease Score Top Affiliating Genes
1 acute asthma 31.4 RNASE3 IL5 ADRB2
2 allergic asthma 31.3 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
3 chronic asthma 30.9 RNASE3 IL5 CCL11
4 near-fatal asthma 30.8 CCL5 ADRB2
5 ige responsiveness, atopic 30.3 RNASE3 IL5 IL10
6 bacterial pneumonia 30.2 IL10 ELANE CXCL8
7 enterocolitis 30.2 IL10 CXCL8
8 bronchopneumonia 30.0 IL10 ELANE CXCL8
9 pulmonary emphysema 29.9 MMP9 ELANE CXCL8
10 duodenal ulcer 29.8 IL1RN IL10 CXCL8
11 alpha-1-antitrypsin deficiency 29.8 MMP3 ELANE CXCL8
12 pertussis 29.7 IL10 CXCL8 CCL5 CCL11
13 esophagitis 29.6 RNASE3 IL5 IL10 CXCL8 CCL11
14 hypereosinophilic syndrome 29.6 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
15 allergic rhinitis 29.6 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
16 pre-eclampsia 29.5 MMP9 IL10 CXCL8 ADRB2
17 otitis media 29.4 RNASE3 MUC5AC IL5 IL10 CXCL8 CCL11
18 dermatitis 29.4 RNASE3 IL5 IL10 CXCL8 CCL5 CCL11
19 neutropenia 29.3 IL1RN IL10 ELANE CXCL8
20 adult respiratory distress syndrome 29.3 IL1RN IL1R1 IL10 ELANE CXCL8 ADRB2
21 gastritis 29.3 IL1RN IL10 CXCL8 CCL5
22 cerebral palsy 29.2 MMP3 IL10 CXCL8 CCL7 ADRB2
23 bronchitis 29.2 RNASE3 MMP9 IL5 IL10 ELANE CXCL8
24 rhinitis 29.2 RNASE3 IL5 IL10 CXCL8 CCL7 CCL5
25 body mass index quantitative trait locus 11 29.0 MMP3 IL10 CXCL8 CCL5 CCL11 ADRB2
26 thrombocytopenia 28.9 PIK3C2A MMP9 IL1RN IL10 CXCL8
27 asthma 28.8 RNASE3 MUC5AC MMP9 IL5 IL1RN IL1R1
28 respiratory failure 28.8 RNASE3 PIK3C2A MUC5AC IL5 IL1RN IL1R1
29 lung disease 28.5 RNASE3 MUC5AC MMP9 IL5 IL10 ELANE
30 proteasome-associated autoinflammatory syndrome 1 27.8 RNASE3 MMP9 IL5 IL1RN IL1R1 IL10
31 myopathy 10.6
32 pneumothorax 10.5
33 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.4
34 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.4
35 pemphigoid 10.4 IL5 CCL11
36 metabolic acidosis 10.4
37 loeffler endocarditis 10.4 RNASE3 IL5
38 perinephritis 10.3 PIK3C2A ADRB2
39 cough variant asthma 10.3 RNASE3 IL5
40 eosinophilic gastritis 10.3 IL5 CCL11
41 myoglobinuria 10.3
42 quadriplegia 10.3
43 respiratory syncytial virus infectious disease 10.3 IL5 CCL5
44 disseminated eosinophilic collagen disease 10.3 RNASE3 IL5
45 kimura disease 10.3 RNASE3 IL5
46 vernal conjunctivitis 10.3 RNASE3 MUC5AC
47 adhesive otitis media 10.3 RNASE3 CCL11
48 ceftriaxone allergy 10.3 IL5 IL10
49 lung mucoepidermoid carcinoma 10.3 MUC5AC CXCL8
50 eustachian tube disease 10.3 RNASE3 CCL11

Comorbidity relations with Status Asthmaticus via Phenotypic Disease Network (PDN): (show all 13)

Anxiety Asthma
Bronchitis Chronic Maxillary Sinusitis
Chronic Pulmonary Heart Disease Conn's Syndrome
Esophagitis Heart Disease
Hypertension, Essential Hypothyroidism
Oral Candidiasis Osteoporosis
Respiratory Failure

Graphical network of the top 20 diseases related to Status Asthmaticus:

Diseases related to Status Asthmaticus

Symptoms & Phenotypes for Status Asthmaticus

MGI Mouse Phenotypes related to Status Asthmaticus:

# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 ADRB2 CCL11 CCL5 ELANE IL10 IL1R1
2 immune system MP:0005387 9.4 ADRB2 CCL11 CCL5 ELANE IL10 IL1R1

Drugs & Therapeutics for Status Asthmaticus

Drugs for Status Asthmaticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 Formoterol Fumarate Phase 4
Beclomethasone Phase 4 4419-39-0 20469
12 Sympathomimetics Phase 4
13 Respiratory System Agents Phase 4
14 Anti-Asthmatic Agents Phase 4
15 Adrenergic beta-Agonists Phase 4
16 Adrenergic Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Tocolytic Agents Phase 4
19 Neurotransmitter Agents Phase 4
20 Bronchodilator Agents Phase 4
21 Pharmaceutical Solutions Phase 4
22 Hormone Antagonists Phase 4
23 Hormones Phase 4
24 Gastrointestinal Agents Phase 4
25 Antiemetics Phase 4
26 Methylprednisolone Acetate Phase 4
27 Anti-Inflammatory Agents Phase 4
28 glucocorticoids Phase 4
29 Antineoplastic Agents, Hormonal Phase 4
30 BB 1101 Phase 4
Montelukast Approved Phase 2, Phase 3 158966-92-8 5281040
Ketamine Approved, Vet_approved Phase 3 6740-88-1 3821
33 Leukotriene Antagonists Phase 2, Phase 3
34 Anesthetics, General Phase 3
35 Anesthetics, Dissociative Phase 3
36 Anesthetics Phase 3
37 Excitatory Amino Acid Antagonists Phase 3
38 Anesthetics, Intravenous Phase 3
39 Analgesics Phase 3
Benralizumab Approved, Investigational Phase 2 1044511-01-4
41 Immunoglobulins Phase 2
42 Antibodies Phase 2
43 Antibodies, Monoclonal Phase 2
Budesonide Approved Phase 1 51333-22-3 63006 5281004
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
47 Cholinergic Agents Phase 1
48 Cholinergic Antagonists Phase 1
49 Neuroprotective Agents Phase 1
50 Protective Agents Phase 1

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Extra-fine Formoterol/Beclomethasone in the Treatment of Asthmatic Crisis Unknown status NCT02345993 Phase 4 Extra fine Formoterol/Beclomethasone
2 Efficacy of a Loading Dose of IV Salbutamol in Children Admitted to a PICU for Severe Acute Asthma or Severe Acute Wheeze Completed NCT03493503 Phase 4 Salbutamol;Sodium Chloride 0.9%
3 Double-blinded Randomized Trial of Terbutaline to Shorten ICU Length of Stay in the Treatment of Status Asthmaticus in Children Completed NCT00124995 Phase 4 terbutaline
4 Continuous Levalbuterol for Treatment of Status Asthmaticus in Children Completed NCT00124176 Phase 4 Racemic albuterol (R+S albuterol);Levalbuterol (R albuterol)
5 Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit Enrolling by invitation NCT03900624 Phase 4 Dexamethasone
6 Comparison of Benzalkonium Chloride Containing Albuterol Versus Preservative Free Albuterol for the Treatment of Status Asthmaticus Suspended NCT02966184 Phase 4 preservative free albuterol
7 Oral Dexamethasone Versus Oral Prednisone in Children Hospitalized With Asthma: A Randomized Control Study Terminated NCT02780479 Phase 4 Dexamethasone;Prednisone
8 Montelukast With Status Asthmaticus, Ages 2-5 Unknown status NCT00491790 Phase 2, Phase 3 Montelukast
9 Pharmacokinetics and Pharmacodynamics of Montelukast in Children, Ages 6 Through 18 Years Old, With Status Asthmaticus Unresponsive to Conventional Treatment Unknown status NCT00494572 Phase 2, Phase 3 Montelukast
10 The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room Completed NCT01524198 Phase 2, Phase 3 Budesonide;Normal saline
11 The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study Not yet recruiting NCT03338205 Phase 3 Ketamine
12 Randomized Double Blind Placebo Controlled Trial of Benralizumab, an Antiinterleukin 5 Receptor α Monoclonal Antibody, Initiated During Hospitalization for Severe Asthma Attack in Reducing Severe Exacerbations: Phase 2B Study Not yet recruiting NCT04617171 Phase 2 Benralizumab 30 MG/ML [Fasenra];Placebos
13 A Phase II, Randomized, Modified Single-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety and Efficacy of MN-221 When Administered Intravenously as an Adjunct to Standard Therapy to Adults With an Acute Exacerbation of Asthma Terminated NCT00683449 Phase 2 Dose Group 1;MN-221 placebo;Dose Group 2;Dose Group 3
14 A Prospective, Randomized, Controlled, Single Center Trial of the Use of Heliox in Children Admitted to the Hospital With Status Asthmaticus Terminated NCT00410150 Phase 2 Helium-oxygen-driven albuterol nebulizer;Oxygen
15 Effect Of Early Initiation Of Noninvasive Positive Pressure Ventilation On ICU Length Of Stay In Children With Status Asthmaticus, A Prospective Randomized Trial Withdrawn NCT01403428 Phase 2
16 High Fidelity Simulation (HFS) Versus Video-case(VC) Trainings in the Assessement and Management of Severe Asthma Attack Among Medical School Students: a Randomized Controlled Study Completed NCT02776358 Phase 1
17 A Phase I, Single Center, Placebo-Controlled, Blinded Pilot Study of Ipratropium Bromide in Children Admitted to the Intensive Care Unit With Status Asthmaticus Completed NCT02872597 Phase 1 Ipratropium;0.9% Sodium Chloride;Albuterol;corticosteroids
18 Nebulized Budesonide Combined With Systemic Corticosteroid in Acute Severe Asthma Managed in the Emergency Department: A Randomized Controlled Trial Recruiting NCT04016220 Phase 1 Budesonide;normal saline
19 Safety and Efficacy of Early Initiation of Noninvasive Positive Pressure Ventilation in Pediatric Patients Admitted With Status Asthmaticus Withdrawn NCT01188473 Phase 1
20 A Prospective Analysis of the Use of Oral Montelukast in Children With Status Asthmaticus Unknown status NCT01770899 Montelukast;Placebo
21 Pharmacokinetics and Pharmacodynamics of Terbutaline Given as a Continuous Intravenous Infusion in Severe Status Asthmaticus Unknown status NCT00750568
22 Comparison Efficacy of Nebulized Magnesium Sulphate to Intravenous Magnesium Sulphate in Children With Severe Acute Asthma Unknown status NCT02112305 isotonic magnesium sulphate;50% magnesium sulphate
23 Risk Factors for Intensive Care Admission of Children With Severe Acute Wheeze or Asthma (SAA) Completed NCT02936778
24 High Frequency Chest Wall Oscillation in Hospital Management of Asthmatic Children Completed NCT00722020
25 Effectiveness and Costs of Albuterol Delivered by MDI With Spacer Versus Nebulizer in Children Hospitalized With Moderate and Severe Asthma Exacerbations Completed NCT00623688
26 Using Pleth Variability to Triage Asthmatics in the Pediatric ED Completed NCT02302261
27 B2-Adrenergic Receptor Polymorphisms: Implications For The Treatment Of Status Asthmaticus In Children Completed NCT00279786
28 Optimizing Vitamin D Status in Children With Pre-school Wheeze or Asthma:a Pilot Study (OPTIVIT) Completed NCT02880930
29 Effectiveness of the Aeroneb Compared to a Jet Nebulizer Fort the Delivery of Bronchodilator Therapy of Acute Severe Asthma Completed NCT03029156
30 High Flow Nasal Cannula Versus Standard Oxygen Therapy in Children With Status Asthmaticus: a Randomized Controlled Trial Recruiting NCT03157102
31 Pilot Randomized Control Trial of Telemedical Support for Paramedics in Simulated Pre-hospital Pediatric Emergencies Enrolling by invitation NCT03742167
32 Bilevel Positive Airway Pressure (BPAP) in Pediatric Asthma Exacerbations: A Pilot Study Not yet recruiting NCT04656587
33 Use of High Frequency Chest Compression (HFCC) in Pediatric Status Asthmaticus Terminated NCT00552448
34 A Prospective, Randomized Trial of Early Versus Delayed BiPAP Administration or Non-positive Pressure Therapy in the Management of Pediatric Status Asthmaticus Withdrawn NCT02539420
35 A Prospective Open Randomized Clinical Trial Comparing Bilevel Positive Airway Pressure (BiPAP) Therapy Against Standard Therapy for Children Hospitalized With an Acute Exacerbation of Asthma Unresponsive to Inhaled Bronchodilators. Withdrawn NCT02347462
36 A Randomized Controlled Trial of Non-Invasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations Withdrawn NCT03219736

Search NIH Clinical Center for Status Asthmaticus

Inferred drug relations via UMLS 70 / NDF-RT 51 :

ethyl ether
hydrocortisone acetate
Hydrocortisone butyrate
hydrocortisone cypionate
hydrocortisone probutate
Hydrocortisone sodium phosphate
Hydrocortisone sodium succinate
hydrocortisone valerate

Cochrane evidence based reviews: status asthmaticus

Genetic Tests for Status Asthmaticus

Anatomical Context for Status Asthmaticus

MalaCards organs/tissues related to Status Asthmaticus:

Heart, Lung, Eye, Bone, Brain, Kidney, Smooth Muscle

Publications for Status Asthmaticus

Articles related to Status Asthmaticus:

(show top 50) (show all 1387)
# Title Authors PMID Year
Acute rhabdomyolysis complicating status asthmaticus in children: case series and review. 54 61
16912630 2006
Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. 61 54
16395068 2006
Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. 54 61
12628991 2003
Prevalence and risk factors of lactic acidosis in children with acute moderate and severe asthma, a prospective observational study. 61
33089387 2021
Point-of-Care Lung Ultrasound to Diagnose the Etiology of Acute Respiratory Failure at Admission to the PICU. 61
33739956 2021
High frequency percussive ventilation as a rescue mode for refractory status asthmaticus - a case study. 61
31668108 2021
Characterization of ketamine usage in a large tertiary-care emergency department. 61
33812331 2021
Difficulty Ventilating: A Case Report on Ventilation Considerations of an Intubated Asthmatic Undergoing Air Medical Critical Care Transport. 61
33637279 2021
Implementation of a Critical Care Asthma Pathway in the PICU. 61
33604577 2021
Pediatric asthma severity scores distinguish suitable inpatient level of care for children admitted for status asthmaticus. 61
31608716 2021
Systemic glucocorticoid at discharge after hospitalization for pediatric asthma: a prospective pilot study. 61
33492180 2021
Comparison of Two Assessment Tools for Hospitalized Subjects With Asthma. 61
32962997 2021
Salbutamol-induced lactic acidosis in status asthmaticus survivor. 61
33435939 2021
High-flow nasal cannula and bilevel positive airway pressure for pediatric status asthmaticus: a single center, retrospective descriptive and comparative cohort study. 61
33401990 2021
Extracorporeal Carbon Dioxide Removal in the Treatment of Status Asthmaticus. 61
33031151 2020
Emergency Department Airway Management for Status Asthmaticus With Respiratory Failure. 61
32723860 2020
Identification of the Physiologically Difficult Airway in the Pediatric Emergency Department. 61
32896033 2020
Physiologically variable ventilation in a rabbit model of asthma exacerbation. 61
33070949 2020
Burden of Asthma in Elderly Japanese Patients: Using Hospital-Based Administrative Claims Data. 61
32504384 2020
Descriptions and outcomes of cardiac evaluations in pediatric patients hospitalized for asthma. 61
31288567 2020
Greater length of stay and hospital charges for severe asthma in children with depression or anxiety. 61
32902930 2020
Danger in the vapor? ECMO for adolescents with status asthmaticus after vaping. 61
31352844 2020
Comparison of two continuous nebulized albuterol doses in critically ill children with status asthmaticus. 61
31119958 2020
Bilevel Positive Airway Pressure ventilation efficiently improves respiratory distress in initial hours treating children with severe asthma exacerbation. 61
31806384 2020
A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency. 61
33043128 2020
Stress ulcer prophylaxis in children with status asthmaticus receiving systemic corticosteroids: a descriptive study assessing frequency of clinically important bleeding. 61
31046509 2020
Unsuspected foreign-body aspiration in adult patient with status asthmaticus: Case report. 61
32551105 2020
Terbutaline and aminophylline as second-line therapies for status asthmaticus in the pediatric intensive care unit. 61
32426910 2020
Trends in Intravenous Magnesium Use and Outcomes for Status Asthmaticus in Children's Hospitals from 2010 to 2017. 61
32584247 2020
Usefulness of extracorporeal membrane oxygenation in status asthmaticus with severe tracheal stenosis. 61
32675965 2020
Improving the Pediatric Emergency Department Learning Experience: A Simulation-Based Orientation for Pediatric PGY 1 Residents. 61
32656335 2020
Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children. 61
32227683 2020
The Reemergence of Ketamine for Treatment in Critically Ill Adults. 61
32317593 2020
Pediatric Boot Camp Series: Longitudinal Care for a Child With Asthma-From the Emergency Department to Outpatient Clinic. 61
32656327 2020
Asthma deaths in North Carolina: 1999-2016. 61
30810458 2020
Outcome of status asthmaticus at a pediatric intensive care unit in Hong Kong. 61
31965725 2020
SCAMP-ering Toward Improved Quality of Care in Children With Status Asthmaticus. 61
32358332 2020
Standardized Protocol Is Associated With a Decrease in Continuous Albuterol Use and Length of Stay in Critical Status Asthmaticus. 61
32084098 2020
Treatment of Open-Angle Glaucoma and Ocular Hypertension with Preservative-Free Tafluprost/Timolol Fixed-Dose Combination Therapy: The VISIONARY Study. 61
32072493 2020
Status asthmaticus requiring extracorporeal membrane oxygenation associated with rhinovirus infection. 61
30882258 2020
Improving Influenza Vaccination in Hospitalized Children With Asthma. 61
32107285 2020
Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study. 61
32164622 2020
Recurrent endobronchial inflammatory myofibroblastic tumors: Novel treatment options. 61
31986238 2020
Association of various weight-based doses of continuous albuterol on hospital length of stay. 61
31994959 2020
A winter to remember! Extracorporeal membrane oxygenation for life-threatening asthma in children: A case series and review of literature. 61
31860773 2020
Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus. 61
31432470 2020
Enoximone in status asthmaticus. 61
32280667 2020
Volatile anaesthetic for treatment of respiratory failure from status asthmaticus requiring extracorporeal membrane oxygenation. 61
31948977 2020
Extracorporeal carbon dioxide removal in heart-beating donor with acute severe asthma: A case report. 61
32042585 2020
High-frequency oscillatory ventilation as a rescue for severe asthma crisis in a child. 61
32974029 2020

Variations for Status Asthmaticus

Expression for Status Asthmaticus

Search GEO for disease gene expression data for Status Asthmaticus.

Pathways for Status Asthmaticus

Pathways related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.53 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
Show member pathways
13.4 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
Show member pathways
13.23 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
Show member pathways
13.09 IL5 IL1R1 IL10 CXCL8 CCL7 CCL5
Show member pathways
13.08 MMP9 MMP3 IL5 IL1RN IL1R1 IL10
Show member pathways
12.72 RNASE3 IL5 IL10 CXCL8 CCL11
Show member pathways
12.22 CXCL8 CCL7 CCL5 CCL11
Show member pathways
12.17 IL10 CXCL8 CCL7 CCL5 CCL11
10 12.11 MMP9 MMP3 ELANE CXCL8
Show member pathways
Show member pathways
11.91 PIK3C2A IL5 IL1R1
13 11.89 MMP9 IL1R1 CXCL8
14 11.85 MMP9 MMP3 CCL5
15 11.8 IL1R1 IL10 CXCL8
Show member pathways
17 11.75 MMP3 CXCL8 CCL5
18 11.71 MMP9 MMP3 IL10 CXCL8 CCL11
19 11.68 IL5 IL1R1 IL10
Show member pathways
11.54 MMP9 MMP3 CXCL8
21 11.53 IL5 IL10 CCL11
22 11.51 MMP9 MMP3 CXCL8
Show member pathways
24 11.35 MMP9 IL5 CXCL8 CCL5 CCL11
25 11.33 IL5 IL10 CCL11
26 11.26 MMP9 MMP3 ELANE CCL5
27 11.04 IL1RN IL1R1 IL10 CXCL8 CCL5
28 10.87 MMP9 CCL5
29 10.84 IL5 IL10 CXCL8 CCL7 CCL5 CCL11

GO Terms for Status Asthmaticus

Cellular components related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN
2 extracellular region GO:0005576 9.44 RNASE3 MUC5AC MMP9 MMP3 IL5 IL1RN

Biological processes related to Status Asthmaticus according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.13 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
2 positive regulation of cell migration GO:0030335 9.88 MMP9 CCL7 CCL5 CCL11
3 cellular response to tumor necrosis factor GO:0071356 9.83 CXCL8 CCL7 CCL5 CCL11
4 cellular response to interferon-gamma GO:0071346 9.79 CCL7 CCL5 CCL11
5 cellular calcium ion homeostasis GO:0006874 9.76 ELANE CCL7 CCL5 CCL11
6 extracellular matrix disassembly GO:0022617 9.74 MMP9 MMP3 ELANE
7 monocyte chemotaxis GO:0002548 9.72 CCL7 CCL5 CCL11
8 cellular response to interleukin-1 GO:0071347 9.71 CXCL8 CCL7 CCL5 CCL11
9 inflammatory response GO:0006954 9.7 IL5 IL1RN IL1R1 CXCL8 CCL7 CCL5
10 lymphocyte chemotaxis GO:0048247 9.69 CCL7 CCL5 CCL11
11 positive regulation of JAK-STAT cascade GO:0046427 9.67 IL5 IL10 CCL5
12 neutrophil chemotaxis GO:0030593 9.67 CXCL8 CCL7 CCL5 CCL11
13 chemotaxis GO:0006935 9.65 RNASE3 CXCL8 CCL7 CCL5 CCL11
14 positive regulation of immunoglobulin production GO:0002639 9.63 IL5 IL10
15 response to amyloid-beta GO:1904645 9.63 MMP9 MMP3
16 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CXCL8 CCL5
17 neutrophil activation GO:0042119 9.62 CXCL8 CCL5
18 chemokine-mediated signaling pathway GO:0070098 9.62 CXCL8 CCL7 CCL5 CCL11
19 regulation of neuroinflammatory response GO:0150077 9.61 MMP9 MMP3
20 eosinophil chemotaxis GO:0048245 9.61 CCL7 CCL5 CCL11
21 cellular response to UV-A GO:0071492 9.6 MMP9 MMP3
22 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.59 IL1RN IL10
23 response to molecule of bacterial origin GO:0002237 9.58 IL10 CXCL8
24 positive regulation of natural killer cell chemotaxis GO:2000503 9.56 CCL7 CCL5
25 immune response GO:0006955 9.56 IL5 IL1RN IL1R1 IL10 CXCL8 CCL7
26 positive regulation of cellular biosynthetic process GO:0031328 9.54 CXCL8 CCL5
27 cytokine-mediated signaling pathway GO:0019221 9.28 MMP9 MMP3 IL5 IL1RN IL1R1 IL10

Molecular functions related to Status Asthmaticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.5 MMP9 MMP3 ELANE
2 CCR chemokine receptor binding GO:0048020 9.33 CCL7 CCL5 CCL11
3 CCR1 chemokine receptor binding GO:0031726 9.26 CCL7 CCL5
4 chemokine activity GO:0008009 9.26 CXCL8 CCL7 CCL5 CCL11
5 cytokine activity GO:0005125 9.17 IL5 IL1RN IL10 CXCL8 CCL7 CCL5

Sources for Status Asthmaticus

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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