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SE
MCID: STT001
MIFTS: 59

Status Epilepticus (SE)

Categories: Neuronal diseases, Rare diseases
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Aliases & Classifications for Status Epilepticus

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MalaCards integrated aliases for Status Epilepticus:

Name: Status Epilepticus 11 19 28 53 5 43 14 16 71 75 31 33
Grand Mal Status Epilepticus 71 31
Generalized Convulsive Status Epilepticus 19
Epilepsy with Status Epilepticus 33
Grand Mal Status 11
Gcse 19
Se 19

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 31
ICD11: 33


External Ids:

Disease Ontology 11 DOID:1824
MeSH 43 D013226
NCIt 49 C85079
SNOMED-CT 68 155039002
ICD10 31 G41 G41.0 G41.9
UMLS 71 C0038220 C0311335
Sources

Summaries for Status Epilepticus

About this section

GARD: 19 A life-threatening situation in which the brain is in a continuous state of seizure.

MalaCards based summary: Status Epilepticus, also known as grand mal status epilepticus, is related to epilepsy, pyridoxine-dependent and lennox-gastaut syndrome, and has symptoms including seizures and symptomatic seizures. An important gene associated with Status Epilepticus is GALC (Galactosylceramidase), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Dopamine-DARPP32 Feedback onto cAMP Pathway. The drugs Phenytoin and Levetiracetam have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and amygdala, and related phenotypes are nervous system and normal

Wikipedia: 75 Status epilepticus (SE), or status seizure, is a single seizure lasting more than 5 minutes or 2 or more... more...
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Related Diseases for Status Epilepticus

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Diseases related to Status Epilepticus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 989)
# Related Disease Score Top Affiliating Genes
1 epilepsy, pyridoxine-dependent 32.4 SCN1A PCDH19 KCNQ2
2 lennox-gastaut syndrome 32.2 SCN1A PCDH19 KCNQ2 GRIN2B
3 generalized epilepsy with febrile seizures plus 32.1 SCN1A PVALB PCDH19 LGI1 KCNQ2
4 dravet syndrome 32.1 SCN1A PVALB PCDH19 LGI1 KCNQ2 GRIN2B
5 temporal lobe epilepsy 31.7 PVALB NPY LGI1 GRIN2B GFAP CALB1
6 neonatal hypoxic and ischemic brain injury 31.5 PVALB ENO2 BDNF
7 limbic encephalitis 31.3 LGI1 GRIN2B GRIA1
8 early myoclonic encephalopathy 31.3 SCN1A POLG PCDH19 LGI1 KCNQ2
9 toxic encephalopathy 31.2 JUN GRIN2B GRIA1 GFAP BDNF
10 epilepsy 31.2 SCN1A PVALB POLG PCDH19 NPY LGI1
11 focal epilepsy 31.2 SCN1A PVALB PCDH19 NPY LGI1 KCNQ2
12 epilepsy, idiopathic generalized 31.1 SCN1A PVALB PCDH19 LGI1 KCNQ2
13 landau-kleffner syndrome 31.1 SCN1A PCDH19 KCNQ2 GRIN2B
14 epilepsy, myoclonic juvenile 31.0 SCN1A PVALB PCDH19 LGI1 KCNQ2
15 movement disease 31.0 POLG LGI1 GFAP BDNF
16 alcohol use disorder 31.0 NPY GRIN2B BDNF
17 amnestic disorder 31.0 LGI1 GRIN2B GRIA1 FOS BDNF
18 childhood absence epilepsy 30.9 SCN1A PVALB PCDH19 LGI1 KCNQ2 GRIN2B
19 benign epilepsy with centrotemporal spikes 30.9 SCN1A PCDH19 LGI1 KCNQ2 GRIN2B
20 headache 30.8 SCN1A NPY BDNF
21 hydrocephalus 30.8 NPY GFAP ENO2 BDNF
22 autism spectrum disorder 30.8 SCN1A PCDH19 GRIN2B GRIA2 GRIA1 GFAP
23 progressive myoclonus epilepsy 30.7 SCN1A PCDH19 KCNQ2
24 akinetic mutism 30.7 LGI1 ENO2
25 speech and communication disorders 30.7 LGI1 GRIN2B GFAP BDNF
26 west syndrome 30.7 SCN1A PVALB POLG PCDH19 NPY LGI1
27 psychotic disorder 30.7 PVALB NPY GRIN2B GRIA2 GRIA1 FOS
28 anxiety 30.7 NPY GRIN2B GRIA1 FOS BDNF
29 withdrawal disorder 30.7 GRIN2B FOS BDNF
30 anterograde amnesia 30.6 LGI1 FOS BDNF
31 encephalomalacia 30.6 GFAP GALC BDNF
32 major depressive disorder 30.5 PVALB NPY GRIA1 FOS BDNF
33 partial motor epilepsy 30.5 SCN1A POLG PCDH19 LGI1 KCNQ2
34 dystonia 30.5 PVALB POLG NPY GRIN2B BDNF
35 ganglioglioma 30.5 PVALB GFAP ENO2
36 choreatic disease 30.5 PVALB POLG LGI1 GRIN2B BDNF
37 early infantile epileptic encephalopathy 30.4 TRAK1 SCN1A PCDH19 KCNQ2 GRIN2B
38 bipolar disorder 30.4 PVALB POLG GRIN2B GRIA2 GRIA1 GFAP
39 epilepsy with generalized tonic-clonic seizures 30.4 SCN1A PCDH19 KCNQ2
40 speech disorder 30.4 PVALB LGI1 GRIN2B CALB1
41 sleep disorder 30.4 NPY FOS BDNF
42 migraine with or without aura 1 30.4 SCN1A POLG NPY KCNQ2 GRIN2B GRIA1
43 attention deficit-hyperactivity disorder 30.4 SCN1A PVALB NPY GRIN2B GRIA2 GRIA1
44 fragile x syndrome 30.4 GRIN2B GRIA2 GRIA1 BDNF
45 episodic ataxia 30.4 SCN1A LGI1 KCNQ2
46 developmental and epileptic encephalopathy 30.3 TRAK1 SCN1A PVALB POLG PCDH19 LGI1
47 substance abuse 30.3 NPY GRIN2B FOS BDNF
48 wernicke-korsakoff syndrome 30.3 PVALB CALB1 BDNF
49 pertussis 30.3 NPY JUN FOS
50 developmental and epileptic encephalopathy 7 30.2 SCN1A KCNQ2

Comorbidity relations with Status Epilepticus via Phenotypic Disease Network (PDN): (show all 17)


Acute Cystitis Alzheimer Disease, Familial, 1
Bronchitis Cerebral Atherosclerosis
Decubitus Ulcer Deficiency Anemia
Encephalopathy Epilepsy, Focal, with Speech Disorder and with or Without Impaired Intellectual Development
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Status Epilepticus:



Diseases related to Status Epilepticus
Sources

Symptoms & Phenotypes for Status Epilepticus

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UMLS symptoms related to Status Epilepticus:


seizures; symptomatic seizures

MGI Mouse Phenotypes related to Status Epilepticus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.23 BDNF CALB1 ENO2 FOS GALC GAP43
2 normal MP:0002873 10.07 BDNF CALB1 FOS GFAP GRIA1 GRIA2
3 growth/size/body region MP:0005378 10.03 BDNF ENO2 FOS GALC GAP43 GFAP
4 behavior/neurological MP:0005386 9.89 BDNF CALB1 ENO2 FOS GALC GFAP
5 no phenotypic analysis MP:0003012 9.87 BDNF GRIA1 GRIA2 GRIN2B JUN POLG
6 mortality/aging MP:0010768 9.5 BDNF FOS GALC GAP43 GFAP GRIA2
Sources

Drugs & Therapeutics for Status Epilepticus

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Drugs for Status Epilepticus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
2
Levetiracetam Approved Phase 3 102767-28-2 441341 5284583
3
Clonazepam Approved, Illicit Phase 3 1622-61-3 2802
4
Fosphenytoin Approved, Investigational Phase 3 93390-81-9 56339
5
Paraldehyde Approved, Investigational Phase 3 123-63-7 31264
6
Ganaxolone Approved, Investigational Phase 3 38398-32-2 22023730 6918305
7
Valproic acid Approved, Investigational Phase 3 99-66-1 3121
8
Topiramate Approved Phase 3 97240-79-4 5284627
9
Alprazolam Approved, Illicit, Investigational Phase 3 28981-97-7 2118
10
Thiopental Approved, Vet_approved Phase 3 76-75-5 3000715
11
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 2, Phase 3 439-14-5 3016
12
Pentobarbital Approved, Investigational, Vet_approved Phase 3 76-74-4 4737
13
Acetazolamide Approved, Vet_approved Phase 2, Phase 3 59-66-5, 1424-27-7 1986
14 Nootropic Agents Phase 3
15 Pharmaceutical Solutions Phase 3
16 Sodium Channel Blockers Phase 3
17 Diuretics, Potassium Sparing Phase 3
18 Anti-Anxiety Agents Phase 3
19 Psychotropic Drugs Phase 3
20 Antiemetics Phase 3
21 Gastrointestinal Agents Phase 3
22 Carbonic Anhydrase Inhibitors Phase 2, Phase 3
23 diuretics Phase 2, Phase 3
24
Coal tar Approved Phase 1, Phase 2 8007-45-2
25
Ethanol Approved Phase 1 64-17-5 702
26 Strawberry Approved Phase 1
27
Cannabidiol Approved, Investigational Phase 1 13956-29-1 521372 644019
28
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
29
Clobazam Approved, Illicit 22316-47-8 2789
30
Vigabatrin Approved 60643-86-9, 68506-86-5 5665
31
Eltanolone Approved, Investigational 516-54-1, 128-20-1 31402 92786
32
Sage Approved
33 Liver Extracts
34 Epinephryl borate
35 GABA Agonists
36 Neurosteroids

Interventional clinical trials:

(show top 50) (show all 84)
# Name Status NCT ID Phase Drugs
1 Levetiracetam Versus Phenytoin in Management of Pediatric Status Epilepticus: a Randomized Clinical Trial Unknown status NCT04176887 Phase 4 Levetiracetam Injection;Phenytoin Injection
2 Comparison of Efficacy of Phenytoin With Levetireacetam for the Management of Children With Status Epilepticus Recruiting NCT04829838 Phase 4 intravenous levetireacetam
3 Efficacy of add-on PEramPanel in Focal Motor Status Epilepticus Unknown status NCT04309721 Phase 3 Perampanel;Placebo
4 Refractory Status Epilepticus: Plasmatic Levels Monitorization Utility Completed NCT01586208 Phase 3 valproic acid (VPA)
5 A Multi-center, Open-label, Non-controlled Study To Evaluate The Efficacy And Safety Of Lorazepam Intravenously Administered In Subjects With Status Epilepticus Or Repetitive Status Epilepticus Completed NCT02239380 Phase 3 Lorazepam
6 Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus in Adults Patients Completed NCT01870024 Phase 3 Clonazepam;Fosphenytoin;Placebo;Lorazepam
7 A Double-blind Randomized Clinical Trial of the Efficacy of IM Midazolam Versus IV Lorazepam in the Pre-hospital Treatment of Status Epilepticus by Paramedics Completed NCT00809146 Phase 3 Intramuscular route of active treatment;Intravenous route of active treatment
8 A Phase 3, Multicenter, Open-label Extension Study of Buccally Administered MHOS/SHP615 in Pediatric Patients With Status Epilepticus (Convulsive) in Community Settings Completed NCT03336450 Phase 3 SHP615;MHOS/SHP615
9 A Multicenter, Randomized, Blinded, Comparative Effectiveness Study of Fosphenytoin, Valproic Acid, or Levetiracetam in the Emergency Department Treatment of Patients With Benzodiazepine-refractory Status Epilepticus. Completed NCT01960075 Phase 3 Fosphenytoin;Levetiracetam;Valproic acid
10 A Phase 3, Multicenter, Open-label Study to Determine the Efficacy, Safety, and Pharmacokinetics of Buccally Administered MHOS/SHP615 in Pediatric Patients With Status Epilepticus (Convulsive) in the Hospital or Emergency Room Completed NCT03336645 Phase 3 SHP615
11 Intra-Nasal vs. Intra-Venous Lorazepam for Control of Acute Seizures in Children: Prospective Open Labeled Randomized Equivalence Trial Completed NCT00735527 Phase 3 Lorazepam
12 Use Of Lorazepam For The Treatment Of Pediatric Status Epilepticus: A Randomized, Double-Blinded Trial Of Lorazepam And Diazepam Completed NCT00621478 Phase 2, Phase 3 lorazepam or diazepam
13 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of SAGE-547 Injection in the Treatment of Subjects With Super-Refractory Status Epilepticus Completed NCT02477618 Phase 3 SAGE-547;Placebo
14 Phase III Randomized Study of Diazepam Vs Lorazepam Vs Placebo for Prehospital Treatment of Status Epilepticus Completed NCT00004297 Phase 3 diazepam;lorazepam
15 Childhood Convulsive Status Epilepticus - In Search Of Optimal Drug Management In A Resource Limited Setting Completed NCT03650270 Phase 3 Phenobarbital
16 A Randomised Trial to Compare the Efficacy and Safety of Intranasal Lorazepam and Intramuscular Paraldehyde in the Treatment of Convulsions in Children Completed NCT00116064 Phase 3 intranasal lorazepam;intramuscular paraldehyde
17 Evaluation of the Interests of a Therapeutic Hypothermia Procedure in Convulsive Status EPILEPTICUS in Adults in Intensive Care - HYBERNATUS Study Completed NCT01359332 Phase 3
18 Efficiency of Levetiracetam Intravenous in Association With Clonazepam Versus Clonazepam Alone in Prehospital Care of Generalised Tonicoclonic Status Epilepticus Completed NCT01150331 Phase 3 Levetiracetam/Clonazepam;Clonazepam/Placebo levetiracetam IV
19 A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy and Safety of Intravenous Ganaxolone in Status Epilepticus Recruiting NCT04391569 Phase 3 Ganaxolone;Placebo
20 Possible Immuno-Modulatory Effect of Tocilizumab in Patients With Refractory Status Epilepticus. Recruiting NCT05346666 Phase 3 Tocilizumab Prefilled Syringe [Actemra]. propofole, phenobarbital, midazolam
21 Efficacy of Lacosamide in Neonatal Status Epilepticus: A Randomized Controlled Study Recruiting NCT05291455 Phase 3 Lacosamide;Phenobarbital
22 Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial) Recruiting NCT05263674 Phase 3 Rapid sedation
23 A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Outpatient, Parallel-Group Study to Assess the Efficacy and Safety of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures Recruiting NCT05077904 Phase 3 Staccato alprazolam
24 An Open-Label, Multicenter, Outpatient Extension Study to Evaluate the Safety and Tolerability of Staccato Alprazolam in Study Participants 12 Years of Age and Older With Stereotypical Prolonged Seizures Enrolling by invitation NCT05076617 Phase 3 Staccato alprazolam
25 Efficacy of Ketamine in Refractory Convulsive Status Epilepticus in Children: a Multicenter, Randomized, Controlled, Open-label, No-profit, With Sequential Design Study. Terminated NCT02431663 Phase 3 Ketamine
26 Buccal, Intranasal or Intravenous Lorazepam for the Treatment of Acute Convulsions in Children in Blantyre, Malawi: a Randomized Trial Terminated NCT00343096 Phase 3 Lorazepam
27 A Randomized Clinical Trial for the Treatment of Refractory Status Epilepticus Terminated NCT00265616 Phase 3 propofol;thiopental/pentobarbital
28 Non-inferiority Prospective Randomized Trial of Acetazolamide Versus Diazepam in Patients With Continuous Spike and Wave in Sleep (CSWS)/Landau Kleffner Syndrome (LKS) Terminated NCT02904265 Phase 2, Phase 3 Diazepam;Acetazolamide
29 Evaluation of Efficacy and Safety of Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus Withdrawn NCT02726867 Phase 3 levetiracetam;lacosamide;Ketamine;Phenobarbital
30 Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus- a Pilot Study Withdrawn NCT03115489 Phase 2, Phase 3 Traditional Treatment (Group T);Ketamine Infusion (Group K)
31 Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China Unknown status NCT03025906 Phase 2 Phenobarbital;Valproate
32 Safety and Tolerability of Add-on Levetiracetam in Status Epilepticus Unknown status NCT00362141 Phase 2 levetiracetam (add-on)
33 Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children Completed NCT04926844 Phase 2 Levetiracetam;Midazolam;Placebo
34 A Double-Blind Randomized, Placebo Controlled Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Intravenous Ganaxolone as Adjunctive Therapy to Treat Subjects With Status Epilepticus Completed NCT03350035 Phase 2 IV Ganaxolone active;IV Placebo, non-active
35 An Open-Label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of SAGE-547 Injection as Adjunctive Therapy for the Treatment of Super-Refractory Status Epilepticus Completed NCT02052739 Phase 1, Phase 2 SAGE-547
36 Levetiracetam Versus Sodium Valproate in Children With Refractory Generalized Convulsive Status Epilepticus : An Open Randomized Study Completed NCT02920060 Phase 2 Intravenous levetiracetam;Sodium valproate
37 VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa Recruiting NCT04772547 Phase 2 Vigabatrin Only Product
38 Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus Withdrawn NCT00603135 Phase 2 first-line i/v-levetiracetam
39 Phase 1, Open-Label, Comparison Study to Evaluate the Safety and Pharmacokinetics of a Single Intramuscular Administration of 10 mg Midazolam Using an Auto-Injector vs Marketed Midazolam Vials in Healthy Adults. Completed NCT04679623 Phase 1 Seizalam
40 Use of Lorazepam for the Treatment of Status Epilepticus Completed NCT00114569 Phase 1 lorazepam
41 Efficacy of Epidiolex in Patients With Electrical Status Epilepticus of Sleep (ESES). Recruiting NCT04721691 Phase 1 Epidiolex 100 mg/mL Oral Solution
42 Management of Non Convulsive Status Epilepticus Unknown status NCT03245099
43 Diagnostic Value of Prehospital EEG in Non-convulsive Status Epilepticus Unknown status NCT02344706
44 Management Strategies for Electrical Status Epilepticus During Sleep Unknown status NCT03251820 corticosteroid
45 A Multi-center Clinical Study of Children With Status Epilepticus in China Unknown status NCT03378687
46 Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures Unknown status NCT01268904 Valproate
47 Feasibility and Tolerability of the Ketogenic Diet in the Treatment of Refractory Status Epilepticus in a Neurointensive Care Unit. Completed NCT01796574
48 Efficacy of Intravenous Clonazepam According to the Dosage in Children Status Epilepticus Completed NCT04287361
49 Pilot Randomized Control Trial of Telemedical Support for Paramedics in Simulated Pre-hospital Pediatric Emergencies Completed NCT03742167
50 Creation, Implementation, and Analysis of a Seizure Action Plan Completed NCT02995759

Search NIH Clinical Center for Status Epilepticus

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Amobarbital
AMOBARBITAL NA PWDR
Amobarbital Sodium
Diazepam
Etomidate
fosphenytoin
Fosphenytoin sodium
Lorazepam
Midazolam
Midazolam Hydrochloride
Pentobarbital
PENTOBARBITAL NA PWDR
Pentobarbital Sodium
Propofol

Cochrane evidence based reviews: status epilepticus

Sources

Genetic Tests for Status Epilepticus

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Genetic tests related to Status Epilepticus:

# Genetic test Affiliating Genes
1 Status Epilepticus 28
Sources

Anatomical Context for Status Epilepticus

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Organs/tissues related to Status Epilepticus:

MalaCards : Brain, Temporal Lobe, Amygdala, Cortex, Bone Marrow, Liver, Occipital Lobe
Sources

Publications for Status Epilepticus

About this section

Articles related to Status Epilepticus:

(show top 50) (show all 14069)
# Title Authors PMID Year
1
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. 53 62
20138553 2010
2
Vascular changes in epilepsy: functional consequences and association with network plasticity in pilocarpine-induced experimental epilepsy. 53 62
20004712 2010
3
The unfolding clinical spectrum of POLG mutations. 53 62
19578034 2009
4
Elevated serum neuron-specific enolase in patients with temporal lobe epilepsy: a video-EEG study. 53 62
18595663 2008
5
Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus. 53 62
18294203 2008
6
Cyclophosphamide for anti-GAD antibody-positive refractory status epilepticus. 53 62
18177354 2008
7
Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation. 53 62
17727632 2007
8
Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. 53 62
16901909 2006
9
Histone modifications in status epilepticus induced by kainate. 53 62
16598677 2006
10
Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. 53 62
16469864 2006
11
Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression. 53 62
16091474 2005
12
Reciprocal changes of CD44 and GAP-43 expression in the dentate gyrus inner molecular layer after status epilepticus in mice. 53 62
15191797 2004
13
Use of neuron-specific enolase for assessing the severity and outcome in patients with neurological disorders. 53 62
14689039 2004
14
Transient downregulation of Sema3A mRNA in a rat model for temporal lobe epilepsy. A novel molecular event potentially contributing to mossy fiber sprouting. 53 62
12821384 2003
15
Serum neuron-specific enolase in children with febrile seizures: time profile and prognostic implications. 53 62
12767459 2003
16
Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic-clonic seizures. 53 62
11166790 2001
17
Knockdown of AMPA receptor GluR2 expression causes delayed neurodegeneration and increases damage by sublethal ischemia in hippocampal CA1 and CA3 neurons. 53 62
10531425 1999
18
Serum neuron-specific enolase in the major subtypes of status epilepticus. 53 62
10078721 1999
19
Status epilepticus increases CSF levels of neuron-specific enolase and alters the blood-brain barrier. 53 62
9595992 1998
20
Selective reduction of GluR2 protein in adult hippocampal CA3 neurons following status epilepticus but prior to cell loss. 53 62
9825961 1998
21
Serum NSE in status epilepticus. 53 62
8649598 1996
22
The GluR2 hypothesis: Ca(++)-permeable AMPA receptors in delayed neurodegeneration. 53 62
9246466 1996
23
Serum neuron-specific enolase in human status epilepticus. 53 62
7783877 1995
24
Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury? 53 62
8326831 1993
25
Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel. 62
36018183 2023
26
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review. 62
36474454 2023
27
Status Epilepticus: A Neurologic Emergency. 62
36333039 2023
28
Pharmacist involvement with antiepileptic therapy for status epilepticus in the emergency department. 62
36192245 2023
29
Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus. 62
35912523 2023
30
Expression of Concern "4,4'-Diisothiocyanatostilbene-2,2'-disulfonic acid attenuates spontaneous recurrent seizures and vasogenic edema following lithium-pilocarpine induced status epilepticus" [Neurosci. Lett. 653 (2017) 51-57]. 62
36435618 2023
31
Seizure detection based on wearable devices: A review of device, mechanism, and algorithm. 62
36255131 2022
32
Prevalence and Predictors of Seizure Clusters in Pediatric Patients With Epilepsy: The Harvard-Yale Pediatric Seizure Cluster Study. 62
36208614 2022
33
Status Epilepticus Related Takotsubo Syndrome - A Case Report. 62
35470412 2022
34
[New aspects in neurointensive and emergency medicine: the most important studies in a review and overview]. 62
35380221 2022
35
Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit. 62
36285875 2022
36
Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice. 62
36094027 2022
37
Development and Validation of a Nomogram Based on the Epidemiology-Based Mortality Score in Status Epilepticus (EMSE) Parameters to Predict 30-day Mortality in Status Epilepticus. 62
35778648 2022
38
The clinical analysis of new-onset status epilepticus. 62
36214088 2022
39
Modulation of Microglia M2 Polarization and Alleviation of Hippocampal Neuron Injury By MiR-106b-5p/RGMa in a Mouse Model of Status Epilepticus. 62
35789312 2022
40
Parthanatos participates in glutamate-mediated HT22 cell injury and hippocampal neuronal death in kainic acid-induced status epilepticus rats. 62
35909335 2022
41
Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection. 62
35916714 2022
42
Epilepsy and inborn errors of metabolism in adults: The diagnostic odyssey of a young woman with medium-chain acyl-coenzyme A dehydrogenase deficiency. 62
35869793 2022
43
A Delayed Presentation of Arginase Deficiency Presenting with Status Epilepticus. 62
36474391 2022
44
Glymphatic system impairment in patients with status epilepticus. 62
35835880 2022
45
Outcomes from a Spanish Expanded Access Program on cannabidiol treatment in pediatric and adult patients with epilepsy. 62
36327646 2022
46
Causes of New-Onset Seizures and Their Treatment in Children With Non-CNS Malignancies: A Retrospective Study in a Tertiary Care Center. 62
36182697 2022
47
[Genetic analysis of a child with combined oxidative phosphorylation deficiency 14 due to variant of FARS2 gene]. 62
36453966 2022
48
Parallel roles of neuroinflammation in feline and human epilepsies. 62
36209994 2022
49
Usefulness of arterial spin labeling in identifying status epilepticus secondary to acquired thrombotic thrombocytopenic purpura. 62
36425942 2022
50
Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency. 62
36149836 2022
Sources

Variations for Status Epilepticus

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ClinVar genetic disease variations for Status Epilepticus:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SRRM2 NM_016333.4(SRRM2):c.6777_6778del (p.Arg2260fs) MICROSAT Likely Pathogenic
 1707520 GRCh37: 16:2817303-2817304
GRCh38: 16:2767302-2767303
2 GALC NM_000153.4(GALC):c.850G>A (p.Gly284Ser) SNV Likely Pathogenic
 374024 rs377274761 GRCh37: 14:88434737-88434737
GRCh38: 14:87968393-87968393
3 GALC NM_000153.4(GALC):c.196G>A (p.Ala66Thr) SNV Likely Pathogenic
 374023 rs1057518843 GRCh37: 14:88454867-88454867
GRCh38: 14:87988523-87988523
4 overlap with 4 genes GRCh37/hg19 Xp22.31(chrX:6624655-7894210)x1 CN LOSS Uncertain Significance
 1330205 GRCh37: X:6624655-7894210
GRCh38:
Sources

Expression for Status Epilepticus

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Search GEO for disease gene expression data for Status Epilepticus.
Sources

Pathways for Status Epilepticus

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Pathways related to Status Epilepticus according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Neuropathic Pain-Signaling in Dorsal Horn Neurons 64
Show member pathways
 12.32 SCN1A GRIN2B GRIA2 GRIA1 FOS BDNF
2
Dopamine-DARPP32 Feedback onto cAMP Pathway 64
12.14 KCNQ2 GRIN2B GRIA2 GRIA1
3
Transcriptional Regulation by MECP2 66
Show member pathways
 12.11 PVALB GRIN2B GRIA2 BDNF
4
Neuroscience 3
11.85 SCN1A NPY KCNQ2 GRIN2B GRIA2 GRIA1
5
Fragile X syndrome 74
Show member pathways
 11.8 GRIN2B GRIA2 GRIA1 BDNF
6
Spinal cord injury 74
11.73 BDNF FOS GAP43 GFAP
7
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 22
Show member pathways
 11.68 GRIN2B GRIA2 GRIA1
8
Unblocking of NMDA receptors, glutamate binding and activation 66
Show member pathways
 11.65 GRIN2B GRIA2 GRIA1
9
Neuroinflammation and glutamatergic signaling 74
11.58 GRIN2B GRIA2 GRIA1 GFAP FOS BDNF
10
Neural Stem Cells and Lineage-specific Markers 65
11.57 GFAP GALC BDNF
11
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.26 JUN FOS CALB1
12
Vitamin D-sensitive calcium signaling in depression 74
10.99 PVALB KCNQ2 GRIN2B CALB1
13
Pathogenesis of ALS 64
10.9 GRIN2B GRIA2 GRIA1
14
S1P2 pathway 61
10.77 JUN FOS
15
Quercetin and Nf-kB / AP-1 induced apoptosis 74
10.73 JUN FOS
16
MIF Action Through Endocytic Pathway 64
10.62 JUN FOS
17
Neuroinflammation 74
10.55 JUN FOS
Sources

GO Terms for Status Epilepticus

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Cellular components related to Status Epilepticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 10.1 TRAK1 GRIA2 GRIA1 GAP43 CALB1 BDNF
2 synaptic membrane GO:0097060 9.85 GRIN2B GRIA1 ENO2
3 neuron projection GO:0043005 9.81 CALB1 ENO2 FOS GRIA1 GRIN2B NPY
4 neuronal cell body GO:0043025 9.7 SCN1A PVALB GRIA2 GRIA1 ENO2 CALB1
5 transcription factor AP-1 complex GO:0035976 9.56 JUN FOS
6 synapse GO:0045202 9.36 PVALB LGI1 KCNQ2 GRIN2B GRIA2 GRIA1

Biological processes related to Status Epilepticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 10.02 NPY KCNQ2 GRIN2B GRIA2 GRIA1
2 monoatomic ion transmembrane transport GO:0034220 9.8 SCN1A KCNQ2 GRIN2B GRIA2 GRIA1
3 ionotropic glutamate receptor signaling pathway GO:0035235 9.63 GRIN2B GRIA2 GRIA1
4 glutamate receptor signaling pathway GO:0007215 9.26 GRIN2B GRIA2 GRIA1
5 regulation of presynaptic membrane potential GO:0099505 8.8 SCN1A GRIN2B GRIA1

Molecular functions related to Status Epilepticus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ligand-gated monoatomic ion channel activity GO:0015276 9.63 GRIN2B GRIA2 GRIA1
2 AMPA glutamate receptor activity GO:0004971 9.56 GRIA2 GRIA1
3 ionotropic glutamate receptor activity GO:0004970 9.26 GRIN2B GRIA2 GRIA1
4 monoatomic ion channel activity GO:0005216 9.02 SCN1A KCNQ2 GRIN2B GRIA2 GRIA1
Sources

Sources for Status Epilepticus

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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