MCID: STT004
MIFTS: 41

Steatorrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Steatorrhea

MalaCards integrated aliases for Steatorrhea:

Name: Steatorrhea 12 29 55 44 15
Fatty Stool 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10602
MeSH 44 D045602
NCIt 50 C86917
UMLS 73 C0038238

Summaries for Steatorrhea

MalaCards based summary : Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and zollinger-ellison syndrome. An important gene associated with Steatorrhea is PNLIP (Pancreatic Lipase), and among its related pathways/superpathways are Lipoprotein metabolism and Bile secretion. The drugs Pancrelipase and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and colon, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may be bulky and difficult... more...

Related Diseases for Steatorrhea

Diseases related to Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 pancreatic steatorrhea 32.6 CCK CELA1 PNLIP SCT
2 zollinger-ellison syndrome 30.4 SCT SST
3 cystic fibrosis 29.6 CFTR PNLIP SCT
4 pancreatic agenesis 1 29.5 CFTR PNLIP SCT
5 diarrhea 29.4 CCK SST TMPRSS15
6 duodenal ulcer 29.2 CCK SCT SST
7 exocrine pancreatic insufficiency 29.0 CCK CFTR PNLIP SCT
8 pancreatitis 27.3 APOC2 CCK CFTR PNLIP SCT SST
9 acute pancreatitis 26.9 APOC2 CCK PNLIP SCT SST TMPRSS15
10 celiac disease 1 11.3
11 tropical sprue 11.3
12 blind loop syndrome 11.2
13 glucose intolerance 11.2
14 bile acid malabsorption, primary 11.0
15 pancreatitis, hereditary 10.9
16 bile acid synthesis defect, congenital, 2 10.9
17 bile acid synthesis defect, congenital, 1 10.9
18 hypobetalipoproteinemia, familial, 1 10.9
19 familial lipoprotein lipase deficiency 10.5 APOC2 PNLIP
20 pancreatic gastrinoma 10.5 SCT SST
21 hyperlipoproteinemia, type iv 10.4 APOC2 SLC10A2
22 glucagonoma 10.4 SCT SST
23 hyperinsulinemic hypoglycemia, familial, 2 10.4 SCT SST
24 angiodysplasia 10.4 SCT SST
25 vipoma 10.4 SCT SST
26 duodenal atresia 10.4 CFTR SCT
27 dumping syndrome 10.4 SCT SST
28 biliary dyskinesia 10.4 CCK SCT
29 duodenal disease 10.3 CCK SCT
30 recurrent acute pancreatitis 10.3 CFTR SCT
31 gastrinoma 10.3 SCT SST
32 postcholecystectomy syndrome 10.2 CCK SST
33 bile duct disease 10.2 CCK SLC10A2
34 biliary tract disease 10.2 CCK SLC10A2
35 secretory diarrhea 10.1 CFTR SST
36 hypoparathyroidism 10.1
37 functional gastric disease 10.1 CCK SST
38 rasmussen encephalitis 10.1 CCK SST
39 diabetes mellitus 10.0
40 duodenitis 10.0
41 short bowel syndrome 10.0 CCK SST
42 dyspepsia 10.0 CCK SST
43 stomach disease 9.9 CCK SST
44 chylomicron retention disease 9.9 MTTP SLC10A2
45 duodenogastric reflux 9.9 CCK SCT SST
46 lymphoma 9.9
47 pancreatic cholera 9.9 CCK SCT SST
48 duodenal gastrinoma 9.9 CCK SCT SST
49 gastrointestinal system disease 9.8 CCK SCT SST
50 cholelithiasis 9.8 CCK SST

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to Steatorrhea

Symptoms & Phenotypes for Steatorrhea

MGI Mouse Phenotypes related to Steatorrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOC2 CCK CFTR MTTP PNLIP SLC10A2

Drugs & Therapeutics for Steatorrhea

Drugs for Steatorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53608-75-6
2
Glycerol Approved, Investigational Phase 4 56-81-5 753
3
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
4 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 pancreatin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Analgesics Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Antirheumatic Agents Phase 4
11 Cyclooxygenase Inhibitors Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Protective Agents Phase 4
14 Tocolytic Agents Phase 4
15
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
16 Antacids Phase 3
17 Anti-Ulcer Agents Phase 3
18 Proton Pump Inhibitors Phase 3
19 Pharmaceutical Solutions Phase 2, Phase 3
20
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
21
Cefazolin Approved Phase 2 25953-19-9 656510 33255
22
Dalteparin Approved Phase 2 9005-49-6
23
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
24
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
25
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
26 Hypoglycemic Agents Phase 2
27 insulin Phase 2
28 Insulin, Globin Zinc Phase 2
29 Anti-Bacterial Agents Phase 2
30 Antibiotics, Antitubercular Phase 2
31 calcium heparin Phase 2
32 Heparin, Low-Molecular-Weight Phase 2
33
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
34
Phytonadione Approved, Investigational, Nutraceutical Phase 1 84-80-0 4812 5284607
35 Antifibrinolytic Agents Phase 1
36 Coagulants Phase 1
37 Hemostatics Phase 1
38 Micronutrients Phase 1
39 Trace Elements Phase 1
40 Vitamins Phase 1
41 Menaquinone Nutraceutical Phase 1
42 naphthoquinone Nutraceutical Phase 1
43 Vitamin K Nutraceutical Phase 1
44
Nicotine Approved Not Applicable 54-11-5 942 89594
45
Teriparatide Approved, Investigational 52232-67-4 16133850
46
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
47 Bile Acids and Salts
48 Antibodies
49 Immunoglobulins
50 Cholic Acids

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4 Panzytrat® 25,000;Kreon® 25,000
2 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
3 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
4 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;glycerin suppository
5 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
6 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3 Ultrase® MT12
7 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3 Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
8 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3 PANCRECARB® (pancrelipase);Placebo
9 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3 Ultrase® MT20;Placebo
10 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3 Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
11 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3 Ultrase® MT20
12 Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00981214 Phase 3 EUR-1008 (APT-1008)
13 Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation Completed NCT01967888 Phase 2, Phase 3 Reparixin;Placebo
14 Creon in HIV Patients With Steatorrhea Terminated NCT00623025 Phase 3 Creon 25000;Placebo
15 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
16 An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption Completed NCT00217204 Phase 2 Pancrelipase microtablets
17 Tolerance and Digestibility of a New Formula in Healthy Infants Completed NCT01184378 Phase 2
18 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2 VIOKASE 16
19 Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality Completed NCT00782795 Phase 2 Pioglitazone;Placebo
20 Islet Autotransplantation in Patients at Very High-risk Pancreatic Anastomosis Recruiting NCT01346098 Phase 2
21 A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Completed NCT00676702 Phase 1 Pancrelipase in combination with Ensure Plus
22 Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy Unknown status NCT01023594 Not Applicable
23 Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis Completed NCT00006063 Not Applicable pancrelipase with bicarbonate
24 Effect of Potato Fiber on Appetite and Fecal Fat Excretion Completed NCT02957318 Not Applicable
25 Horton & Maizy Pilot Study for Resistant to Starch Completed NCT01338571
26 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
27 Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis Completed NCT01527084 Not Applicable
28 Isolated Roux Loop Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy Completed NCT01859806 Not Applicable
29 The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms" Completed NCT02121626
30 Special Investigation of LipaCreon on Long-term Use in Patients With Pancreatic Exocrine Insufficiency Completed NCT01427725
31 Celiac Disease Diagnosis in Patients With Weakly Positive Serum Anti-Transglutaminase: Duodenal Anti-Endomysium Assay. Recruiting NCT02242123
32 The REPLACE Registry Recruiting NCT03115086
33 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
34 Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Recruiting NCT01427712
35 The Natural History of Chronic Pancreatitis Active, not recruiting NCT03324698
36 Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following Surgery Withdrawn NCT01094535 Not Applicable Synthetic Human Secretin

Search NIH Clinical Center for Steatorrhea

Cochrane evidence based reviews: steatorrhea

Genetic Tests for Steatorrhea

Genetic tests related to Steatorrhea:

# Genetic test Affiliating Genes
1 Steatorrhea 29

Anatomical Context for Steatorrhea

MalaCards organs/tissues related to Steatorrhea:

41
Testes, Bone, Colon, Pancreatic Islet, Pancreas, Liver, Small Intestine

Publications for Steatorrhea

Articles related to Steatorrhea:

(show top 50) (show all 316)
# Title Authors Year
1
Fecal Elastase Fails to Detect Steatorrhea in Patients With Locally Advanced Pancreatic Cancer. ( 29521945 )
2018
2
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass. ( 28089681 )
2017
3
RE: Steatorrhea, Hyperoxaluria andA Colonic Hyperproliferation After Roux-en-Y Gastric Bypass. ( 28881188 )
2017
4
Dietary green-plant thylakoids decrease gastric emptying and gut transit, promote changes in the gut microbial flora, but does not cause steatorrhea. ( 27777602 )
2016
5
Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. ( 26877248 )
2016
6
50 years ago in the journal of pediatrics: disaccharidase deficiencies with steatorrhea. ( 24359902 )
2014
7
Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. ( 23395568 )
2013
8
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate. ( 23499748 )
2013
9
Pancreatic lipomatosis with massive steatorrhea. ( 22081194 )
2011
10
Education and imaging. Gastrointestinal: "floating oil droplets in the colonic fluid": colonoscopic findings in a patient with pancreatic exocrine insufficiency and steatorrhea. ( 21564288 )
2011
11
Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes? ( 21377551 )
2011
12
Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. ( 20146370 )
2010
13
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. ( 19034041 )
2009
14
Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. ( 19238028 )
2009
15
Spontaneous exocrine pancreas hypoplasia in specific pathogen-free C3HeB/FeJ and 101/H mouse pups causes steatorrhea and runting. ( 17536623 )
2007
16
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. ( 16954337 )
2007
17
Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes? ( 16505538 )
2006
18
The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. ( 16868481 )
2006
19
Unresponsive or non-compliant steatorrhea in cystic fibrosis? ( 16765107 )
2006
20
An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. ( 16863712 )
2006
21
The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. ( 12728924 )
2003
22
High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. ( 14560984 )
2003
23
Rethinking growth failure in Alagille syndrome: the role of dietary intake and steatorrhea. ( 12394373 )
2002
24
Association between steatorrhea, growth, and immunologic status in children with perinatally acquired HIV infection. ( 11177089 )
2001
25
Massive steatorrhea in a child due to isolated pancreatic hypoplasia. ( 11721073 )
2001
26
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? ( 11374718 )
2001
27
Positive results on tests for steatorrhea in persons consuming olestra potato chips. ( 10681282 )
2000
28
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. ( 10950038 )
2000
29
Fecal weight determination can unfortunately not replace unpopular and costly fecal fat estimation in the diagnosis of steatorrhea. ( 10211425 )
1999
30
Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake. ( 10026440 )
1999
31
Steatorrhea and weight loss in a 72-year-old man: primary biliary cirrhosis? Celiac disease? Bacterial overgrowth? What else? ( 9820402 )
1998
32
Steatorrhea cannot be excluded where there is a fecal weight below 0.200 kg per day and a high fecal consistency. ( 9890341 )
1998
33
Esophageal impairment in adult celiac disease with steatorrhea. ( 9707045 )
1998
34
Prevalence and significance of steatorrhea in patients with active Graves' disease. ( 9672342 )
1998
35
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. ( 9520087 )
1998
36
Can pancreatic steatorrhea be diagnosed without chemical analysis? ( 9387033 )
1997
37
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? ( 9178698 )
1997
38
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. ( 9163777 )
1997
39
Acid steatocrit: a simple, rapid gravimetric method to determine steatorrhea. ( 9399770 )
1997
40
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. ( 9149203 )
1997
41
Evaluation of steatorrhea during acute infectious enteritis. ( 8890096 )
1996
42
Steatorrhea: a common manifestation in patients with HIV/AIDS. ( 8878143 )
1996
43
Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. ( 7883852 )
1995
44
Steatorrhea in Japanese patients with chronic pancreatitis. ( 7719419 )
1995
45
Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. ( 8174441 )
1994
46
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. ( 8113582 )
1994
47
Steatocrit: a reliable semiquantitative method for detection of steatorrhea. ( 7806830 )
1994
48
Octreotide decreases biliary and pancreatic exocrine function, and induces steatorrhea in healthy subjects. ( 7827373 )
1994
49
Can diarrhea cause secondary steatorrhea? ( 1587441 )
1992
50
Fecal alpha 1-antitrypsin clearance in the differential diagnosis of steatorrhea. ( 1300854 )
1992

Variations for Steatorrhea

Expression for Steatorrhea

Search GEO for disease gene expression data for Steatorrhea.

Pathways for Steatorrhea

GO Terms for Steatorrhea

Cellular components related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOC2 CCK CELA1 PNLIP SCT SST
2 extracellular space GO:0005615 9.1 APOC2 CCK CELA1 PNLIP SCT SST

Biological processes related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.16 APOC2 PNLIP
2 lipoprotein transport GO:0042953 8.96 APOC2 MTTP
3 chylomicron assembly GO:0034378 8.62 APOC2 MTTP

Molecular functions related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CCK SCT SST

Sources for Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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