MCID: STT004
MIFTS: 40

Steatorrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Steatorrhea

MalaCards integrated aliases for Steatorrhea:

Name: Steatorrhea 12 29 55 44 15
Fatty Stool 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10602
MeSH 44 D045602
NCIt 50 C86917
SNOMED-CT 68 27868004 66187002
UMLS 73 C0038238

Summaries for Steatorrhea

MalaCards based summary : Steatorrhea, also known as fatty stool, is related to pancreatic steatorrhea and zollinger-ellison syndrome. An important gene associated with Steatorrhea is PNLIP (Pancreatic Lipase), and among its related pathways/superpathways are Lipoprotein metabolism and Bile secretion. The drugs Pancrelipase and Glycerol have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and liver, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Steatorrhea (or steatorrhoea) is the presence of excess fat in feces. Stools may be bulky and difficult... more...

Related Diseases for Steatorrhea

Diseases related to Steatorrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 pancreatic steatorrhea 33.3 CCK CELA1 PNLIP SCT
2 zollinger-ellison syndrome 30.3 SCT SST
3 diarrhea 29.9 CCK CFTR SST TMPRSS15
4 exocrine pancreatic insufficiency 29.9 CCK CFTR PNLIP SCT
5 pancreatic agenesis 1 29.7 CFTR PNLIP SCT
6 duodenal ulcer 29.6 CCK SCT SST
7 pancreatitis 29.5 APOC2 CCK CFTR PNLIP SCT SST
8 acute pancreatitis 28.6 APOC2 CCK CFTR PNLIP SCT SST
9 celiac disease 1 11.4
10 tropical sprue 11.4
11 blind loop syndrome 11.4
12 glucose intolerance 11.4
13 bile acid malabsorption, primary 11.2
14 bile acid synthesis defect, congenital, 2 11.1
15 bile acid synthesis defect, congenital, 1 11.1
16 pancreatitis, hereditary 11.1
17 hypoparathyroidism 10.3
18 cystic fibrosis 10.2
19 diabetes mellitus 10.2
20 familial lipoprotein lipase deficiency 10.2 APOC2 PNLIP
21 gastrinoma 10.1 SCT SST
22 hyperlipoproteinemia, type iv 10.1 APOC2 SLC10A2
23 glucagonoma 10.1 SCT SST
24 insulinomatosis and diabetes mellitus 10.1 SCT SST
25 angiodysplasia 10.1 SCT SST
26 vipoma 10.1 SCT SST
27 biliary dyskinesia 10.1 CCK SCT
28 dumping syndrome 10.1 SCT SST
29 recurrent acute pancreatitis 10.1 CFTR SCT
30 duodenal atresia 10.1 CFTR SCT
31 postcholecystectomy syndrome 10.1 CCK SST
32 small intestine cancer 10.1 SCT SST
33 space motion sickness 10.1 CCK SCT
34 maturity-onset diabetes of the young, type 7 10.0 CCK SCT
35 secretory diarrhea 10.0 CFTR SST
36 functional gastric disease 10.0 CCK SST
37 rasmussen encephalitis 10.0 CCK SST
38 bile duct disease 10.0 CCK SLC10A2
39 short bowel syndrome 10.0 CCK SST
40 biliary tract disease 10.0 CCK SLC10A2
41 dyspepsia 10.0 CCK SST
42 chylomicron retention disease 10.0 MTTP SLC10A2
43 duodenogastric reflux 10.0 CCK SCT SST
44 pancreatic cholera 10.0 CCK SCT SST
45 duodenal disease 10.0 CCK SCT SST
46 duodenal gastrinoma 9.9 CCK SCT SST
47 gastrointestinal system disease 9.9 CCK SCT SST
48 biliary cirrhosis, primary, 1 9.9
49 pernicious anemia 9.9
50 liver disease 9.9

Graphical network of the top 20 diseases related to Steatorrhea:



Diseases related to Steatorrhea

Symptoms & Phenotypes for Steatorrhea

MGI Mouse Phenotypes related to Steatorrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOC2 CCK CFTR MTTP PNLIP SLC10A2

Drugs & Therapeutics for Steatorrhea

Drugs for Steatorrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 53608-75-6
2
Glycerol Approved, Investigational Phase 4 56-81-5 753
3
Indomethacin Approved, Investigational Phase 4 53-86-1 3715
4 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 pancreatin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Cyclooxygenase Inhibitors Phase 4
7 Analgesics Phase 4
8 Tocolytic Agents Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Antirheumatic Agents Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anti-Inflammatory Agents Phase 4
14 Protective Agents Phase 4
15
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
16 Antacids Phase 3
17 Anti-Ulcer Agents Phase 3
18 Proton Pump Inhibitors Phase 3
19 Pharmaceutical Solutions Phase 2, Phase 3
20
Pioglitazone Approved, Investigational Phase 2 111025-46-8 4829
21
Metoclopramide Approved, Investigational Phase 2 364-62-5 4168
22
Heparin Approved, Investigational Phase 2 9005-49-6 772 46507594
23
Cefazolin Approved Phase 2 25953-19-9 656510 33255
24
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
25
Dalteparin Approved Phase 2 9005-49-6
26 Chelating Agents Phase 2
27 Caseins Phase 2
28 Hypoglycemic Agents Phase 2
29 Insulin, Globin Zinc Phase 2
30 insulin Phase 2
31 Anti-Bacterial Agents Phase 2
32 calcium heparin Phase 2
33 Antibiotics, Antitubercular Phase 2
34 Heparin, Low-Molecular-Weight Phase 2
35
Phytonadione Approved, Investigational Phase 1 84-80-0 4812 5284607
36
Menadione Approved, Nutraceutical Phase 1 58-27-5 4055
37 Micronutrients Phase 1
38 Vitamin K Phase 1
39 Menaquinone Phase 1
40 Trace Elements Phase 1
41 naphthoquinone Phase 1
42 Antifibrinolytic Agents Phase 1
43 Vitamins Phase 1
44 Coagulants Phase 1
45 Hemostatics Phase 1
46
Nicotine Approved Not Applicable 54-11-5 942 89594
47
Teriparatide Approved, Investigational 52232-67-4 16133850
48
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
49
Imidacloprid Vet_approved Not Applicable 105827-78-9 86418
50 Bile Acids and Salts

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 Control of Steatorrhea in Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT01327703 Phase 4 Panzytrat® 25,000;Kreon® 25,000
2 Malabsorption Blood Test:Toward a Novel Approach to Quantify Steatorrhea Completed NCT00572975 Phase 4
3 Enzyme Suppletion in Exocrine Pancreatic Dysfunction Completed NCT01430234 Phase 4 Panzytrat 25.000 FIP-E units of Lipase
4 Rectal Indomethacin to Prevent Post ESWL-pancreatitis Recruiting NCT02797067 Phase 4 indomethacin suppository;Glycerin Suppository
5 Pancreatic Enzyme Suppletion in Pancreatic Cancer Withdrawn NCT01401387 Phase 4
6 Use of Ultrase® MT12 in Young Cystic Fibrosis Children (CF) Completed NCT00880100 Phase 3 Ultrase® MT12
7 Safety and Efficacy Study of Viokase® 16 for the Correction of Steatorrhea Completed NCT00559364 Phase 3 Viokase® 16;Placebo;Proton pump inhibitor (PPI);Omeprazole
8 Evaluation of the Safety and Efficacy of Pancrecarb® MS-16 in Cystic Fibrosis Completed NCT00432861 Phase 3 PANCRECARB® (pancrelipase);Placebo
9 Safety and Efficacy Study of ULTRASE® MT20 in Participants With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (PI) Completed NCT00408317 Phase 3 Ultrase® MT20;Placebo
10 A Study of the Efficacy and Tolerability of Pancrelipase Microtablet (MT) Capsules for the Treatment of Cystic Fibrosis-dependent Exocrine Pancreatic Insufficiency Completed NCT00662675 Phase 3 Pancrease MT 10.5, or MT 21;Placebo for Pancrease MT 10.5 or MT 21
11 Efficacy and Safety of Ultrase® MT20 in Improving the Coefficient of Fat Absorption (CFA) in Children With Cystic Fibrosis (CF) and Pancreatic Insufficiency (PI) Completed NCT00513682 Phase 3 Ultrase® MT20
12 Study of Pancreatic Enzyme Product in Pediatric Participants With Cystic Fibrosis and Exocrine Pancreatic Insufficiency Completed NCT00981214 Phase 3 EUR-1008 (APT-1008)
13 Efficacy and Safety of Reparixin in Pancreatic Islet Auto-transplantation Completed NCT01967888 Phase 2, Phase 3 Reparixin;Placebo
14 Creon in HIV Patients With Steatorrhea Terminated NCT00623025 Phase 3 Creon 25000;Placebo
15 Effectiveness of Pancreatic Enzymes in Patients Pancreatic Insufficient: Comparison of Two Drugs Withdrawn NCT01228643 Phase 3
16 An Effectiveness, Safety, and Palatability Study of Pancrelipase Microtablets in Infants and Toddlers With Cystic Fibrosis and Fat Malabsorption Completed NCT00217204 Phase 2 Pancrelipase microtablets
17 Tolerance and Digestibility of a New Formula in Healthy Infants Completed NCT01184378 Phase 2
18 An Open-Label Study to Evaluate the Intraduodenal Delivery of Enzymes From Administration of VIOKASE16 in Exocrine Pancreatic Insufficiency (EPI) Completed NCT00559052 Phase 2 VIOKASE 16
19 Chronic Pancreatitis. Effect of Pioglitazone on Endocrine Function, Exocrine Function & Structure, Pain & Life Quality Completed NCT00782795 Phase 2 Pioglitazone;Placebo
20 Islet Autotransplantation in Patients at Very High-risk Pancreatic Anastomosis Recruiting NCT01346098 Phase 2
21 A Study of the Enzyme Activity and Safety of Pancrelipase in Patients With Severe Exocrine Pancreatic Insufficiency (EPI) Completed NCT00676702 Phase 1 Pancrelipase in combination with Ensure Plus
22 Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy Unknown status NCT01023594 Not Applicable
23 Special Investigation (All Cases) of LipaCreon in Patients With Pancreatic Exocrine Insufficiency Due to Cystic Fibrosis Unknown status NCT01427712
24 Randomized Study of Pancrelipase With Bicarbonate (PANCRECARB) Capsules in Reducing Steatorrhea in Patients With Cystic Fibrosis Completed NCT00006063 Not Applicable pancrelipase with bicarbonate
25 Effect of Potato Fiber on Appetite and Fecal Fat Excretion Completed NCT02957318 Not Applicable
26 Horton & Maizy Pilot Study for Resistant to Starch Completed NCT01338571
27 Incidence and Risk Factor of Post-ERCP Pancreatitis in Chronic Pancreatitis Completed NCT02781987
28 The Management of Neuroendocrine Tumours: A Nutritional Viewpoint. Completed NCT03592940
29 Timing of Surgical Intervention After Percutaneous Catheter Drainage in STEP UP Approach for Severe Acute Pancreatitis Completed NCT01527084 Not Applicable
30 Isolated Roux Loop Pancreaticojejunostomy Versus Pancreaticogastrostomy After Pancreaticoduodenectomy Completed NCT01859806 Not Applicable
31 The FOCCUS Study: "Focusing on Cancers Chemotherapys' Untreated Symptoms" Completed NCT02121626
32 Special Investigation of LipaCreon on Long-term Use in Patients With Pancreatic Exocrine Insufficiency Completed NCT01427725
33 Celiac Disease Diagnosis in Patients With Weakly Positive Serum Anti-Transglutaminase: Duodenal Anti-Endomysium Assay. Recruiting NCT02242123
34 The REPLACE Registry Recruiting NCT03115086
35 Single-anastomosis Duodeno Ileal Bypass (SADI) Versus Roux-en-Y Gastric Bypass Recruiting NCT03610256 Not Applicable
36 Study of the Diagnostic Value of Stable Calcium Isotope Profiling in Bone and Calcium Disorders Recruiting NCT02252679
37 The Natural History of Chronic Pancreatitis Active, not recruiting NCT03324698
38 Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following Surgery Withdrawn NCT01094535 Not Applicable Synthetic Human Secretin

Search NIH Clinical Center for Steatorrhea

Cochrane evidence based reviews: steatorrhea

Genetic Tests for Steatorrhea

Genetic tests related to Steatorrhea:

# Genetic test Affiliating Genes
1 Steatorrhea 29

Anatomical Context for Steatorrhea

MalaCards organs/tissues related to Steatorrhea:

41
Testes, Bone, Liver, Colon, Pancreas, Small Intestine, Bone Marrow

Publications for Steatorrhea

Articles related to Steatorrhea:

(show top 50) (show all 321)
# Title Authors Year
1
Risk factor for steatorrhea in pediatric chronic pancreatitis patients. ( 30518343 )
2018
2
Fecal Elastase Fails to Detect Steatorrhea in Patients With Locally Advanced Pancreatic Cancer. ( 29521945 )
2018
3
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass. ( 28089681 )
2017
4
RE: Steatorrhea, Hyperoxaluria andA Colonic Hyperproliferation After Roux-en-Y Gastric Bypass. ( 28881188 )
2017
5
Dietary green-plant thylakoids decrease gastric emptying and gut transit, promote changes in the gut microbial flora, but does not cause steatorrhea. ( 27777602 )
2016
6
Risk Factors for Steatorrhea in Chronic Pancreatitis: A Cohort of 2,153 Patients. ( 26877248 )
2016
7
50 years ago in the journal of pediatrics: disaccharidase deficiencies with steatorrhea. ( 24359902 )
2014
8
Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. ( 23395568 )
2013
9
Steatorrhea and hyperoxaluria occur after gastric bypass surgery in obese rats regardless of dietary fat or oxalate. ( 23499748 )
2013
10
Pancreatic lipomatosis with massive steatorrhea. ( 22081194 )
2011
11
Education and imaging. Gastrointestinal: "floating oil droplets in the colonic fluid": colonoscopic findings in a patient with pancreatic exocrine insufficiency and steatorrhea. ( 21564288 )
2011
12
Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes? ( 21377551 )
2011
13
Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea. ( 20146370 )
2010
14
Lipoprotein lipase mutation S447X associated with pancreatic calcification and steatorrhea in hyperlipidemic pancreatitis. ( 19034041 )
2009
15
Treatment of irritable bowel syndrome-diarrhea with pancrealipase or colesevelam and association with steatorrhea. ( 19238028 )
2009
16
Spontaneous exocrine pancreas hypoplasia in specific pathogen-free C3HeB/FeJ and 101/H mouse pups causes steatorrhea and runting. ( 17536623 )
2007
17
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution. ( 16954337 )
2007
18
Does pancreatic elastase-1 in stools predict steatorrhea in type 1 diabetes? ( 16505538 )
2006
19
The effects of oral pancreatic enzymes (Creon 10 capsule) on steatorrhea: a multicenter, placebo-controlled, parallel group trial in subjects with chronic pancreatitis. ( 16868481 )
2006
20
Unresponsive or non-compliant steatorrhea in cystic fibrosis? ( 16765107 )
2006
21
An enteric-coated high-buffered pancrelipase reduces steatorrhea in patients with cystic fibrosis: a prospective, randomized study. ( 16863712 )
2006
22
The incidence, pathogenesis and natural history of steatorrhea after bone marrow transplantation. ( 12728924 )
2003
23
High prevalence of steatorrhea in 101 diabetic patients likely to suffer from exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations: a prospective multicenter study. ( 14560984 )
2003
24
Rethinking growth failure in Alagille syndrome: the role of dietary intake and steatorrhea. ( 12394373 )
2002
25
Association between steatorrhea, growth, and immunologic status in children with perinatally acquired HIV infection. ( 11177089 )
2001
26
Massive steatorrhea in a child due to isolated pancreatic hypoplasia. ( 11721073 )
2001
27
Are minimicrosphere pancrelipase capsules effective enough for the treatment of pancreatic steatorrhea? ( 11374718 )
2001
28
Positive results on tests for steatorrhea in persons consuming olestra potato chips. ( 10681282 )
2000
29
A comparison of the efficacy and tolerance of pancrelipase and placebo in the treatment of steatorrhea in cystic fibrosis patients with clinical exocrine pancreatic insufficiency. ( 10950038 )
2000
30
Fecal weight determination can unfortunately not replace unpopular and costly fecal fat estimation in the diagnosis of steatorrhea. ( 10211425 )
1999
31
Study on pancreatic insufficiency (chronic pancreatitis) and steatorrhea in Japanese patients with low fat intake. ( 10026440 )
1999
32
Steatorrhea and weight loss in a 72-year-old man: primary biliary cirrhosis? Celiac disease? Bacterial overgrowth? What else? ( 9820402 )
1998
33
Steatorrhea cannot be excluded where there is a fecal weight below 0.200 kg per day and a high fecal consistency. ( 9890341 )
1998
34
Esophageal impairment in adult celiac disease with steatorrhea. ( 9707045 )
1998
35
Prevalence and significance of steatorrhea in patients with active Graves' disease. ( 9672342 )
1998
36
Determination of fecal fat concentration by near infrared spectrometry for the screening of pancreatic steatorrhea. ( 9520087 )
1998
37
Can pancreatic steatorrhea be diagnosed without chemical analysis? ( 9387033 )
1997
38
Bacterial lipase and high-fat diets in canine exocrine pancreatic insufficiency: a new therapy of steatorrhea? ( 9178698 )
1997
39
Pancreatic steatorrhea, malabsorption, and nutrition biochemistry: a comparison of Japanese, European, and American patients with chronic pancreatitis. ( 9163777 )
1997
40
Acid steatocrit: a simple, rapid gravimetric method to determine steatorrhea. ( 9399770 )
1997
41
Bone mineral density in patients with pancreatic insufficiency and steatorrhea. ( 9149203 )
1997
42
Evaluation of steatorrhea during acute infectious enteritis. ( 8890096 )
1996
43
Steatorrhea: a common manifestation in patients with HIV/AIDS. ( 8878143 )
1996
44
Intestinal lymphangiectasia in a patient with autoimmune polyglandular disease type I and steatorrhea. ( 7883852 )
1995
45
Steatorrhea in Japanese patients with chronic pancreatitis. ( 7719419 )
1995
46
Fat-soluble vitamin concentration in chronic alcohol-induced pancreatitis. Relationship with steatorrhea. ( 8174441 )
1994
47
New enteric-coated high-lipase pancreatic extract in the treatment of pancreatic steatorrhea. ( 8113582 )
1994
48
Steatocrit: a reliable semiquantitative method for detection of steatorrhea. ( 7806830 )
1994
49
Octreotide decreases biliary and pancreatic exocrine function, and induces steatorrhea in healthy subjects. ( 7827373 )
1994
50
Can diarrhea cause secondary steatorrhea? ( 1587441 )
1992

Variations for Steatorrhea

Expression for Steatorrhea

Search GEO for disease gene expression data for Steatorrhea.

Pathways for Steatorrhea

GO Terms for Steatorrhea

Cellular components related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 APOC2 CCK CELA1 PNLIP SCT SST
2 extracellular space GO:0005615 9.1 APOC2 CCK CELA1 PNLIP SCT SST

Biological processes related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 digestion GO:0007586 9.16 CCK SST
2 lipoprotein transport GO:0042953 8.96 APOC2 MTTP
3 chylomicron assembly GO:0034378 8.62 APOC2 MTTP

Molecular functions related to Steatorrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CCK SCT SST

Sources for Steatorrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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