MCID: STR015
MIFTS: 31

Stereotypic Movement Disorder

Categories: Mental diseases

Aliases & Classifications for Stereotypic Movement Disorder

MalaCards integrated aliases for Stereotypic Movement Disorder:

Name: Stereotypic Movement Disorder 12 44 15 70
Stereotyped Repetitive Movements 12
Stereotypy Habit Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2303
ICD9CM 34 307.3
MeSH 44 D019956
SNOMED-CT 67 5507002
ICD10 32 F98.4
UMLS 70 C0038273

Summaries for Stereotypic Movement Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking.

MalaCards based summary : Stereotypic Movement Disorder, also known as stereotyped repetitive movements, is related to trichotillomania and alacrima, achalasia, and mental retardation syndrome, and has symptoms including clonus, tremor and myoclonus. An important gene associated with Stereotypic Movement Disorder is PRODH (Proline Dehydrogenase 1), and among its related pathways/superpathways are Salivary secretion and Galactose metabolism. Affiliated tissues include skin and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Stereotypic movement disorder (SMD) is a motor disorder with onset in childhood involving repetitive,... more...

Related Diseases for Stereotypic Movement Disorder

Diseases related to Stereotypic Movement Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 trichotillomania 10.4
2 alacrima, achalasia, and mental retardation syndrome 10.3
3 impulse control disorder 10.2
4 schizophreniform disorder 10.2 PRODH PRL
5 social phobia 10.1 PRODH PRL
6 echolalia 10.1 PRODH MECP2
7 bone structure disease 10.1 PRODH MECP2
8 potocki-lupski syndrome 10.1 PRODH MECP2
9 sotos syndrome 1 10.1 PRODH MECP2
10 speech disorder 10.1 PRODH MECP2
11 attention deficit-hyperactivity disorder 10.0
12 obsessive-compulsive disorder 10.0
13 pervasive developmental disorder 10.0
14 autism spectrum disorder 10.0
15 tic disorder 10.0
16 movement disease 10.0
17 eating disorder 10.0
18 developmental coordination disorder 10.0
19 developmental dyspraxia 10.0
20 schizoaffective disorder 10.0 PRODH PRL
21 congenital nervous system abnormality 10.0 PRODH MECP2
22 chromosomal duplication syndrome 10.0 PRODH MECP2
23 immunodeficiency-centromeric instability-facial anomalies syndrome 10.0 MECP2 HELLS
24 sleep disorder 9.9 PRODH PRL
25 prader-willi syndrome 9.9 PRODH PRL MECP2
26 fragile x syndrome 9.8 PRODH MECP2 HELLS
27 anxiety 9.8 PRODH PRL AMY1A
28 learning disability 9.8 PRODH MECP2
29 avoidant personality disorder 9.7 AMY1C AMY1B AMY1A
30 sick building syndrome 9.7 AMY1C AMY1B AMY1A
31 dental anomalies and short stature 9.7 AMY1C AMY1B AMY1A
32 phobic disorder 9.5 PRODH AMY1C AMY1B AMY1A
33 major depressive disorder 9.5 PRL AMY1C AMY1B AMY1A
34 bruxism 9.5 MECP2 AMY1C AMY1B AMY1A
35 disease of mental health 8.9 PRODH PRL MECP2 AMY1C AMY1B AMY1A

Graphical network of the top 20 diseases related to Stereotypic Movement Disorder:



Diseases related to Stereotypic Movement Disorder

Symptoms & Phenotypes for Stereotypic Movement Disorder

UMLS symptoms related to Stereotypic Movement Disorder:


clonus; tremor; myoclonus; involuntary movements; athetosis; muscular fasciculation; recurrent muscle twitches (symptom)

GenomeRNAi Phenotypes related to Stereotypic Movement Disorder according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 10.62 AMY1A AMY1B AMY1C
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 10.62 AMY1A AMY1B AMY1C
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 10.62 PRODH
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 10.62 PRODH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 10.62 AMY1A AMY1B AMY1C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-192 10.62 PRODH
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 10.62 PRODH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 10.62 PRODH
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 10.62 PRODH
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-45 10.62 HELLS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 10.62 PRODH
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 10.62 PRODH
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 10.62 AMY1A AMY1B AMY1C PRODH
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-90 10.62 HELLS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-98 10.62 HELLS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-198 9.28 AMY1A AMY1B AMY1C
17 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.28 AMY1A AMY1B AMY1C
18 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.28 AMY1A AMY1B AMY1C

Drugs & Therapeutics for Stereotypic Movement Disorder

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Using Mobile Technology to Reduce Stereotypy in Children With Autism Spectrum Disorders Completed NCT02124720
2 Age Stereotype Priming and Moderating Effects of Social Participation Recruiting NCT04202120

Search NIH Clinical Center for Stereotypic Movement Disorder

Cochrane evidence based reviews: stereotypic movement disorder

Genetic Tests for Stereotypic Movement Disorder

Anatomical Context for Stereotypic Movement Disorder

MalaCards organs/tissues related to Stereotypic Movement Disorder:

40
Skin, Eye

Publications for Stereotypic Movement Disorder

Articles related to Stereotypic Movement Disorder:

(show all 31)
# Title Authors PMID Year
1
Characterization of an unbalanced translocation causing 3q28qter duplication and 10q26.2qter deletion in a patient with global developmental delay and self-injury. 61
33335013 2020
2
Developmental Motor Profile in Preschool Children with Primary Stereotypic Movement Disorder. 61
30895189 2019
3
Stereotypic movement disorder: a case for Procrustes? 61
25039962 2014
4
[Motor disorders in neurodevelopmental disorders. Tics and stereotypies]. 61
25252672 2014
5
Stereotyped movement disorder in ICD-11. 61
25388614 2014
6
Cheek-biting disorder: another stereotypic movement disorder? 61
21889295 2011
7
Autism spectrum disorder in Down syndrome: cluster analysis of Aberrant Behaviour Checklist data supports diagnosis. 61
21883598 2011
8
[Clinical characteristics of Rett Syndrome]. 61
22076893 2011
9
Stereotypic movement disorder: easily missed. 61
20187883 2010
10
Trichotillomania (hair pulling disorder), skin picking disorder, and stereotypic movement disorder: toward DSM-V. 61
20533371 2010
11
Low dimensional temporal organization of spontaneous eye blinks in adults with developmental disabilities and stereotyped movement disorder. 61
19819672 2010
12
Escitalopram treatment of stereotypic movement disorder in an adolescent with mitochondrial disorder and mental retardation. 61
19519269 2009
13
Is trichotillomania a stereotypic movement disorder? An analysis of body-focused repetitive behaviors in people with hair-pulling. 61
19034750 2008
14
Trichotillomania, stereotypic movement disorder, and related disorders. 61
17880861 2007
15
Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities. 61
16958028 2007
16
An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditions. 61
17075554 2006
17
Animal models of obsessive-compulsive disorder: rationale to understanding psychobiology and pharmacology. 61
16650714 2006
18
Psychomotor development and psychopathology in childhood. 61
16697292 2006
19
Psychosurgery for self-injurious behavior in Tourette's disorder. 61
15662144 2004
20
[Stereotypic movement disorder]. 61
14626071 2003
21
Opiate sensitivity test in patients with stereotypic movement disorder and trichotillomania. 61
12369265 2002
22
Stereotypic movement disorder after acquired brain injury. 61
12097226 2002
23
Characteristics of stereotypic movement disorder and self-injurious behavior assessed with the Diagnostic Assessment for the Severely Handicapped (DASH-II). 61
9403928 1997
24
Fluvoxamine for stereotypic behavior in patients with dementia. 61
9161652 1997
25
Stereotypic movement disorder. 61
9164434 1997
26
Dyskinetic movement disorder among adults with mental retardation: phenomenology and co-occurrence with stereotypy. 61
8883667 1996
27
DSM-IV stereotypic movement disorder: persistence of stereotypies of infancy in intellectually normal adolescents and adults. 61
8617696 1996
28
Open trial lamotrigine in the treatment of self-injurious behavior in an adolescent with profound mental retardation. 61
9231320 1996
29
Growth differences associated with compulsive and stereotyped behavior disorders in adults with mental retardation. 61
9160607 1996
30
Psychiatric disorders associated with fragile X in the young female. 61
8380924 1993
31
Electroencephalographic findings in Rett syndrome. 61
2428589 1986

Variations for Stereotypic Movement Disorder

Expression for Stereotypic Movement Disorder

Search GEO for disease gene expression data for Stereotypic Movement Disorder.

Pathways for Stereotypic Movement Disorder

Pathways related to Stereotypic Movement Disorder according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.87 AMY1C AMY1B AMY1A
2
Show member pathways
11.41 AMY1C AMY1B AMY1A
3 10.8 AMY1C AMY1B AMY1A
4 9.75 AMY1C AMY1B AMY1A

GO Terms for Stereotypic Movement Disorder

Cellular components related to Stereotypic Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 PRL MECP2 AMY1C AMY1B AMY1A

Biological processes related to Stereotypic Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin silencing GO:0006342 9.16 MECP2 HELLS
2 carbohydrate metabolic process GO:0005975 9.13 AMY1C AMY1B AMY1A
3 oligosaccharide metabolic process GO:0009311 8.8 AMY1C AMY1B AMY1A

Molecular functions related to Stereotypic Movement Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation binding GO:0043169 9.43 AMY1C AMY1B AMY1A
2 chloride ion binding GO:0031404 9.33 AMY1C AMY1B AMY1A
3 alpha-amylase activity (releasing maltohexaose) GO:0103025 9.13 AMY1C AMY1B AMY1A
4 alpha-amylase activity GO:0004556 8.8 AMY1C AMY1B AMY1A

Sources for Stereotypic Movement Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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