MCID: STR029
MIFTS: 25

Sternal Cleft

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Sternal Cleft

MalaCards integrated aliases for Sternal Cleft:

Name: Sternal Cleft 52 58 29 71
Congenital Sternal Cleft 52
Sternum Bifidum 58
Cleft Sternum 58

Characteristics:

Orphanet epidemiological data:

58
sternal cleft
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Antenatal,Neonatal;

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

MESH via Orphanet 44 C537489
ICD10 via Orphanet 33 Q76.7
UMLS via Orphanet 72 C0265696 C2931507
Orphanet 58 ORPHA2017
SNOMED-CT via HPO 68 11731003
UMLS 71 C2931507

Summaries for Sternal Cleft

MalaCards based summary : Sternal Cleft, also known as congenital sternal cleft, is related to phace association and asternia. Affiliated tissues include heart, eye and bone, and related phenotypes are webbed neck and abnormality of vision

Wikipedia : 74 Sternal clefts are rare congenital malformations that result from defective embryologic fusion of paired... more...

Related Diseases for Sternal Cleft

Diseases related to Sternal Cleft via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 phace association 11.7
2 asternia 11.7
3 pectus excavatum 10.4
4 ectopia cordis 10.4
5 hemangioma 10.4
6 heart septal defect 10.3
7 thoracoabdominal syndrome 10.2
8 aortic aneurysm 10.2
9 patent ductus arteriosus 1 10.2
10 ventricular septal defect 10.2
11 atrial heart septal defect 10.2
12 hemangiomas, cavernous, of face and supraumbilical midline raphe 10.1
13 tetralogy of fallot 10.1
14 cardiac arrest 10.1
15 poland syndrome 10.0
16 omphalocele 10.0
17 subendocardial myocardial infarction 10.0
18 dextrocardia 10.0
19 aneurysm 10.0
20 arteries, anomalies of 9.9
21 coarctation of aorta 9.9
22 coloboma of macula 9.9
23 vater/vacterl association 9.9
24 congenital heart defects, hamartomas of tongue, and polysyndactyly 9.9
25 craniosynostosis with fibular aplasia 9.9
26 gastroschisis 9.9
27 coffin-lowry syndrome 9.9
28 focal dermal hypoplasia 9.9
29 hyperlipoproteinemia, type iii 9.9
30 lipoprotein quantitative trait locus 9.9
31 congenital hypothyroidism 9.9
32 dextro-looped transposition of the great arteries 9.9
33 heart disease 9.9
34 hypothyroidism 9.9
35 vacterl association 9.9
36 mammary paget's disease 9.9
37 subglottic angioma 9.9
38 compartment syndrome 9.9
39 47,xyy 9.9
40 pulmonary venous return anomaly 9.9
41 abdominal wall defect 9.9
42 angiomatosis 9.9
43 dysphagia 9.9
44 bicornuate uterus 9.9
45 midline cervical cleft 9.9
46 right aortic arch 9.9

Graphical network of the top 20 diseases related to Sternal Cleft:



Diseases related to Sternal Cleft

Symptoms & Phenotypes for Sternal Cleft

Human phenotypes related to Sternal Cleft:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 webbed neck 58 31 hallmark (90%) Very frequent (99-80%) HP:0000465
2 abnormality of vision 58 31 hallmark (90%) Very frequent (99-80%) HP:0000504
3 abnormality of the eye 58 Very frequent (99-80%)
4 abnormality of the neck 58 Very frequent (99-80%)

Drugs & Therapeutics for Sternal Cleft

Search Clinical Trials , NIH Clinical Center for Sternal Cleft

Genetic Tests for Sternal Cleft

Genetic tests related to Sternal Cleft:

# Genetic test Affiliating Genes
1 Sternal Cleft 29

Anatomical Context for Sternal Cleft

MalaCards organs/tissues related to Sternal Cleft:

40
Heart, Eye, Bone, Skin, Liver, Thyroid

Publications for Sternal Cleft

Articles related to Sternal Cleft:

(show top 50) (show all 178)
# Title Authors PMID Year
1
Sternal cleft in a newborn. 61
32269149 2020
2
Surgical Repair of Complete Congenital Sternal Cleft Associated With Pectus Excavatum. 61
31207243 2020
3
Complete sternal cleft with tetralogy of Fallot. 61
32030041 2020
4
Ultrasound Evaluation of Dermal Sinuses/Fistulas in Pediatric Patients. 61
31063247 2019
5
Surgical repair of a sternal cleft malformation. 61
32082935 2019
6
Spontaneous Mediastinal Abscess and Sternal Cleft in the Medically Complex Neonate. 61
30939557 2019
7
Successful management of absent sternum in an infant using porcine acellular dermal matrix. 61
30967520 2019
8
Dental root abnormalities in four children with PHACE syndrome. 61
30933385 2019
9
Congenital sternal defect repair in an adult cat with incomplete pentalogy of Cantrell. 61
30986153 2019
10
Primary Closure of a Partial Superior Sternal Cleft in a 27-day-old Neonate: Case Report with Short Review of Literature. 61
31316874 2019
11
PHACES syndrome with ectopia cordis and hemihypertrophy. 61
31191138 2019
12
Congenital Superior Sternal Cleft Repair Using Primary Closure 61
30499240 2019
13
First Sternal Cleft Repair Using a Porous Alumina Ceramic Prosthesis in a 9-Year-Old Child. 61
31463174 2019
14
Oral propranolol in the treatment of proliferating infantile haemangiomas: British Society for Paediatric Dermatology consensus guidelines. 61
29774538 2018
15
Total congenital sternal cleft isolated in a newborn of 20 days: Rare case. 61
29447895 2018
16
Cantrell Syndrome-A Rare Complex Congenital Anomaly: A Case Report and Literature Review. 61
30065917 2018
17
A Neonate with an Unusual Midline Defect and Cardiovascular Anomaly. 61
29379702 2018
18
Evaluation of the morphological characteristic and sex differences of sternum by multi-detector computed tomography. 61
29345718 2018
19
Frequency of sternal variations in living individuals. 61
28396982 2017
20
Reconstruction of Congenital Sternal Clefts: Surgical Experience and Literature Review. 61
29263968 2017
21
Sternal malformations and anesthetic management. 61
29030926 2017
22
Sternal Development and Variations and Anomalies in Patients With Microtia: Evaluation Using 3-Dimensional Computed Tomography. 61
28296686 2017
23
Sternal cleft malformation in a newborn. 61
28801326 2017
24
Congenital cranial ventral abdominal hernia, peritoneopericardial diaphragmatic hernia and sternal cleft in a 4-year-old multiparous pregnant queen. 61
29318024 2017
25
Primary repair of complete sternal cleft associated with absent anterior pericardium. 61
28417483 2017
26
Isolated sternal cleft in a patient with atrial septal defect: A rare sole association. 61
28492212 2017
27
Repair of inferior sternal cleft using a titanium plate in an infant with pentalogy of Cantrell. 61
27609343 2016
28
[The unsightly chest: Analysis and anomaly. Curative or palliative approach?] 61
27423936 2016
29
A method to preserve limbus during penetrating keratoplasty for a case of presumed PHACES syndrome with sclerocornea: A case report. 61
27741106 2016
30
Incidental finding of sternal cleft on technetium-99m-methylene diphosphonate bone scan appearing as a necklace. 61
27833326 2016
31
Primary Closure of A Sternal Cleft in A Neonate. 61
27853697 2016
32
[STERNAL CLEFT – REPORT OF THREE CASES]. 61
30091973 2016
33
Complete sternal cleft - A rare congenital malformation and its repair in a 3-month-old boy: A case report. 61
27046980 2016
34
Isolated Sternal Cleft in a Patient With Coronary Artery Disease. 61
26701621 2016
35
Upper Sternal Cleft With a Complex Congenital Heart Defect: Repair in a Single Stage. 61
26777935 2016
36
Intrauterine diagnosed sternal cleft patient and her management. 61
29078476 2016
37
Complete sternal cleft associated with right clavicular, manubrial, and thyroid hypoplasia, pectus deformity, and spinal anomalies. 61
26456118 2016
38
Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome. 61
28352793 2016
39
Surgical Repair of a Superior Sternal Cleft in an Infant. 61
26788449 2015
40
Reversed autogenous sternal plate flaps for treatment of sternal clefts: A novel technique. 61
26316301 2015
41
Sternal foramina: incidence in Greek population, anatomy and clinical considerations. 61
25552238 2015
42
Sternal cleft: Anaesthetic management of a rare congenital anomaly. 61
26379304 2015
43
Sternal Cleft Associated with Cantrell's Pentalogy in a German Shepherd Dog. 61
26083439 2015
44
Propranolol and prednisolone combination for the treatment of segmental haemangioma in PHACES syndrome. 61
25639889 2015
45
PHACE(S) Syndrome With Absent Intracranial Internal Carotid Artery and Anomalous Circle of Willis. 61
26080245 2015
46
Sternal Cleft and Pectus Excavatum: A Combined Approach for the Correction of a Complex Anterior Chest Wall Malformation in a Teenager. 61
26046903 2015
47
Reconstruction of sternal cleft with autologous cartilage graft in an adult. 61
25178468 2015
48
Sternal "retraction": a novel application of a mandibular distractor in treating ectopia cordis with complete cleft sternum. 61
24042213 2015
49
The cleft sternum: a possible role for pliable prosthetic reconstruction. 61
25807722 2014
50
Mesh-repaired complete sternal cleft complicated by multi-resistant bacterial infection. 61
25374797 2014

Variations for Sternal Cleft

Expression for Sternal Cleft

Search GEO for disease gene expression data for Sternal Cleft.

Pathways for Sternal Cleft

GO Terms for Sternal Cleft

Sources for Sternal Cleft

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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