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MCID: STR019
MIFTS: 31

Steroid-Induced Glaucoma

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Steroid-Induced Glaucoma

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MalaCards integrated aliases for Steroid-Induced Glaucoma:

Name: Steroid-Induced Glaucoma 12 15
Corticosteroid-Induced Glaucoma 12 55 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9946
ICD9CM 35 365.3
SNOMED-CT 68 1654001
UMLS 73 C0339578
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Summaries for Steroid-Induced Glaucoma

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MalaCards based summary : Steroid-Induced Glaucoma, also known as corticosteroid-induced glaucoma, is related to steroid-induced glaucoma - borderline and residual stage corticosteroid-induced glaucoma. An important gene associated with Steroid-Induced Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are RAB GEFs exchange GTP for GDP on RABs and COPI-independent Golgi-to-ER retrograde traffic. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and thymus.

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Related Diseases for Steroid-Induced Glaucoma

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Diseases related to Steroid-Induced Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 steroid-induced glaucoma - borderline 12.5
2 residual stage corticosteroid-induced glaucoma 12.5
3 glaucoma 1, open angle, a 11.3
4 glaucoma, primary open angle 10.0
5 cataract 10.0
6 open-angle glaucoma 10.0
7 uveitis 10.0
8 warburg micro syndrome 10.0 RAB3GAP1 RAB3GAP2
9 warburg micro syndrome 2 10.0 RAB3GAP1 RAB3GAP2
10 warburg micro syndrome 1 10.0 RAB3GAP1 RAB3GAP2
11 warburg micro syndrome 4 9.9 RAB3GAP1 RAB3GAP2
12 neuromyelitis optica 9.9
13 carcinoid syndrome 9.9
14 martsolf syndrome 9.9 RAB3GAP1 RAB3GAP2
15 leukemia, acute lymphoblastic 9.9
16 leukemia 9.9
17 lymphocytic leukemia 9.9
18 panuveitis 9.9
19 vernal conjunctivitis 9.9
20 conjunctivitis 9.9
21 keratoconjunctivitis 9.9
22 vernal keratoconjunctivitis 9.9
23 spastic diplegia 9.8 RAB3GAP1 RAB3GAP2

Graphical network of the top 20 diseases related to Steroid-Induced Glaucoma:



Diseases related to Steroid-Induced Glaucoma
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Symptoms & Phenotypes for Steroid-Induced Glaucoma

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Drugs & Therapeutics for Steroid-Induced Glaucoma

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Drugs for Steroid-Induced Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4 Hormones Phase 4
5 Ophthalmic Solutions Phase 4
6 Anti-Infective Agents Phase 4
7 Immunologic Factors Phase 4,Phase 1,Phase 2
8 Antineoplastic Agents, Hormonal Phase 4
9 Cyclosporins Phase 4
10 Calcineurin Inhibitors Phase 4
11 Pharmaceutical Solutions Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Gastrointestinal Agents Phase 4
14 glucocorticoids Phase 4
15 HIV Protease Inhibitors Phase 4
16 Hormone Antagonists Phase 4
17 Immunosuppressive Agents Phase 4
18 Dermatologic Agents Phase 4
19
protease inhibitors Phase 4
20 Antifungal Agents Phase 4
21 Antirheumatic Agents Phase 4
22 Autonomic Agents Phase 4
23 Antiemetics Phase 4
24 BB 1101 Phase 4
25 Anti-Inflammatory Agents Phase 4
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
27
Hyaluronic acid Approved, Vet_approved Phase 1, Phase 2 9004-61-9 53477741
28
Ranibizumab Approved Phase 2 347396-82-1 459903
29 Adjuvants, Immunologic Phase 1, Phase 2
30 Protective Agents Phase 1, Phase 2
31 Viscosupplements Phase 1, Phase 2
32 Angiogenesis Inhibitors Phase 2,Phase 1
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 1 67-73-2 6215
35 Anecortave Investigational Phase 1 10184-70-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2 Provisc
3 The LIMO Study, Lucentis for Treatment of Uveitic Patients With Refractory Cystoid Macular Oedema Completed NCT01564108 Phase 2 Ranibizumab
4 Prophylactic Anecortave Acetate in Patients With a Retisert Implant Completed NCT00570479 Phase 1 anecortave acetate
5 Gene Polymorphisms of Corticosteroid-induced Ocular Hypertension Recruiting NCT03250819

Search NIH Clinical Center for Steroid-Induced Glaucoma

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Genetic Tests for Steroid-Induced Glaucoma

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Anatomical Context for Steroid-Induced Glaucoma

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MalaCards organs/tissues related to Steroid-Induced Glaucoma:

41
Eye, Endothelial, Thymus
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Publications for Steroid-Induced Glaucoma

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Articles related to Steroid-Induced Glaucoma:

(show top 50) (show all 64)
# Title Authors Year
1
Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma. ( 29850218 )
2018
2
The rescue effect of adalimumab in the treatment of refractory pediatric panuveitis complicated with steroid-induced glaucoma. ( 30294530 )
2018
3
Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in Postpenetrating Keratoplasty Steroid-induced Glaucoma: A Case Report. ( 30059406 )
2018
4
Canaloplasty in Corticosteroid-Induced Glaucoma. Preliminary Results. ( 29439499 )
2018
5
Re: Maleki etA al.: Selective laser trabeculoplasty in controlled uveitis with steroid-induced glaucoma (Ophthalmology. 2016;123:2630-2632). ( 28734340 )
2017
6
Steroid-induced glaucoma in the pediatric population. ( 28087345 )
2017
7
DEX implant intravitreal injection, sustained intraocular hypertension, and steroid-induced glaucoma in patients with no risk factors. ( 28801709 )
2017
8
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness. ( 28924342 )
2017
9
Peripapillary retinoschisis and serous retinal elevation secondary to steroid-induced glaucoma. ( 27521684 )
2016
10
Selective Laser Trabeculoplasty in Controlled Uveitis with Steroid-Induced Glaucoma. ( 27594199 )
2016
11
Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy. ( 26855269 )
2016
12
ExPRESS Mini-Shunt as a Treatment Alternative for Medically Uncontrolled Steroid-Induced Glaucoma in a Pediatric Patient. ( 28101045 )
2016
13
Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma. ( 27341769 )
2016
14
Outcome of primary trabeculotomy ab interno (Trabectome) surgery in patients with steroid-induced glaucoma. ( 27977576 )
2016
15
Steroid-induced glaucoma and childhood blindness. ( 26002945 )
2015
16
Goniotomy for Steroid-Induced Glaucoma: Clinical and Tonographic Evidence to Support Therapeutic Goniotomy. ( 26053210 )
2015
17
Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. ( 26997802 )
2014
18
Comparison of trabeculectomy with mitomycin-C versus medical treatment in moderate stage of steroid induced glaucoma. ( 23715350 )
2013
19
Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma. ( 23548621 )
2013
20
Successful trabeculotomy in a patient with corticosteroid-induced glaucoma with anti-aquaporin 4 antibody-positive neuromyelitis optica: a case report. ( 23575376 )
2013
21
Severe vernal keratoconjunctivitis requiring trabeculectomy with mitomycin C for corticosteroid-induced glaucoma. ( 21575117 )
2012
22
Glaukos(Ar) trabecular stent used to treat steroid-induced glaucoma. ( 22970451 )
2012
23
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21396622 )
2011
24
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21855676 )
2011
25
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21855678 )
2011
26
Steroid-induced glaucoma in children with acute lymphoblastic leukemia: a possible complication. ( 19661822 )
2010
27
Control of steroid-induced glaucoma with surgical excision of sub-Tenon triamcinolone acetonide deposits: a clinical and biochemical approach. ( 20935694 )
2010
28
Visual loss caused by corticosteroid-induced glaucoma: how to avoid it. ( 19734759 )
2009
29
Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. ( 18386038 )
2008
30
Diagnosis of steroid-induced glaucoma after photorefractive keratectomy. ( 18500094 )
2008
31
Prospective, long-term evaluation of steroid-induced glaucoma. ( 16823461 )
2008
32
Steroid-induced glaucoma in an infant. ( 17629528 )
2007
33
Conservative management of refractory steroid-induced glaucoma following anterior subtenon steroid injection. ( 17362470 )
2007
34
Corneal topographic response to intraocular pressure reduction in patients with vernal keratoconjunctivitis and steroid-induced glaucoma. ( 16273087 )
2007
35
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide. ( 16490518 )
2006
36
What's your diagnosis? Steroid-induced glaucoma. ( 17022158 )
2006
37
Corticosteroid-induced glaucoma: a review of the literature. ( 15877093 )
2006
38
Preventing steroid-induced glaucoma. ( 16009853 )
2005
39
In vivo confocal microscopic findings in patients with steroid-induced glaucoma after LASIK. ( 15051211 )
2004
40
Alteration in Matrix Metalloproteinases (MMPS) Activity in Fibroblast Cell Line by Dexamethasone: A Possible Mechanism in Corticosteroid-Induced Glaucoma. ( 17301371 )
2003
41
Steroid-induced glaucoma after laser in situ keratomileusis associated with interface fluid. ( 11927421 )
2002
42
Corticosteroid-induced glaucoma in a child after a scleral reinforcement procedure. ( 12213166 )
2002
43
Effect of latanoprost on intraocular pressure in steroid-induced glaucoma. ( 10782629 )
2000
44
External trabeculotomy for the treatment of steroid-induced glaucoma. ( 11131756 )
2000
45
Corticosteroid-induced glaucoma attributable to an adrenocorticotropin-secreting malignant carcinoid tumor of the thymus. ( 10482103 )
1999
46
Steroid-induced glaucoma in a young woman. ( 9786566 )
1998
47
TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma. ( 9510647 )
1997
48
Corticosteroid-induced glaucoma. ( 8325728 )
1993
49
Steroid induced glaucoma: a report of two cases with a review of morbidity and prescribing in general practice. ( 2374915 )
1990
50
Steroid induced glaucoma and cataract. ( 2807493 )
1989
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Variations for Steroid-Induced Glaucoma

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Expression for Steroid-Induced Glaucoma

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Search GEO for disease gene expression data for Steroid-Induced Glaucoma.
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Pathways for Steroid-Induced Glaucoma

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Pathways related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
RAB GEFs exchange GTP for GDP on RABs 66
10.91 RAB3GAP1 RAB3GAP2
2
COPI-independent Golgi-to-ER retrograde traffic 66
10.07 RAB3GAP1 RAB3GAP2
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GO Terms for Steroid-Induced Glaucoma

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Biological processes related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of GTPase activity GO:0043087 9.4 RAB3GAP1 RAB3GAP2
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.37 DCN MYOC
3 positive regulation of autophagosome assembly GO:2000786 9.32 RAB3GAP1 RAB3GAP2
4 positive regulation of mitochondrial depolarization GO:0051901 9.26 DCN MYOC
5 positive regulation of endoplasmic reticulum tubular network organization GO:1903373 9.16 RAB3GAP1 RAB3GAP2
6 positive regulation of protein lipidation GO:1903061 8.96 RAB3GAP1 RAB3GAP2
7 establishment of protein localization to endoplasmic reticulum membrane GO:0097051 8.62 RAB3GAP1 RAB3GAP2

Molecular functions related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab GTPase binding GO:0017137 8.96 RAB3GAP1 RAB3GAP2
2 Rab guanyl-nucleotide exchange factor activity GO:0017112 8.62 RAB3GAP1 RAB3GAP2
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Sources for Steroid-Induced Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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