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MCID: STR019
MIFTS: 30

Steroid-Induced Glaucoma

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Steroid-Induced Glaucoma

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MalaCards integrated aliases for Steroid-Induced Glaucoma:

Name: Steroid-Induced Glaucoma 12 15
Corticosteroid-Induced Glaucoma 12 55 73

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9946
ICD9CM 35 365.3
SNOMED-CT 68 1654001 193550003
UMLS 73 C0339578
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Summaries for Steroid-Induced Glaucoma

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MalaCards based summary : Steroid-Induced Glaucoma, also known as corticosteroid-induced glaucoma, is related to residual stage corticosteroid-induced glaucoma and steroid-induced glaucoma - borderline. An important gene associated with Steroid-Induced Glaucoma is MYOC (Myocilin), and among its related pathways/superpathways are RAB GEFs exchange GTP for GDP on RABs and COPI-independent Golgi-to-ER retrograde traffic. The drugs Ephedrine and Pseudoephedrine have been mentioned in the context of this disorder. Affiliated tissues include eye.

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Related Diseases for Steroid-Induced Glaucoma

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Diseases related to Steroid-Induced Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 residual stage corticosteroid-induced glaucoma 12.3
2 steroid-induced glaucoma - borderline 12.3
3 glaucoma 1, open angle, a 11.2
4 warburg micro syndrome 2 10.1 RAB3GAP1 RAB3GAP2
5 warburg micro syndrome 1 10.0 RAB3GAP1 RAB3GAP2
6 warburg micro syndrome 4 10.0 RAB3GAP1 RAB3GAP2
7 glaucoma, primary open angle 9.9
8 cataract 9.9
9 open-angle glaucoma 9.9
10 uveitis 9.9
11 martsolf syndrome 9.9 RAB3GAP1 RAB3GAP2
12 spastic diplegia 9.8 RAB3GAP1 RAB3GAP2
13 neuromyelitis optica 9.8
14 leukemia, acute lymphoblastic 9.8
15 leukemia 9.8
16 lymphoblastic leukemia 9.8
17 vernal conjunctivitis 9.8
18 retinitis 9.8
19 conjunctivitis 9.8
20 keratoconjunctivitis 9.8
21 vernal keratoconjunctivitis 9.8
22 warburg micro syndrome 9.6 RAB3GAP1 RAB3GAP2

Graphical network of the top 20 diseases related to Steroid-Induced Glaucoma:



Diseases related to Steroid-Induced Glaucoma
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Symptoms & Phenotypes for Steroid-Induced Glaucoma

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Drugs & Therapeutics for Steroid-Induced Glaucoma

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Drugs for Steroid-Induced Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ephedrine Approved Phase 4 299-42-3 9294
2
Pseudoephedrine Approved Phase 4 90-82-4 7028
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5 Dexamethasone acetate Phase 4 1177-87-3
6 glucocorticoids Phase 4
7
protease inhibitors Phase 4
8 Respiratory System Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 Nasal Decongestants Phase 4
11 Cyclosporins Phase 4
12 Tetrahydrozoline Phase 4
13 HIV Protease Inhibitors Phase 4
14 Hormone Antagonists Phase 4
15 Dermatologic Agents Phase 4
16 Ophthalmic Solutions Phase 4
17 Hormones Phase 4
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
19 Vasoconstrictor Agents Phase 4
20 Peripheral Nervous System Agents Phase 4
21 Pharmaceutical Solutions Phase 4
22 Immunosuppressive Agents Phase 4
23 Anti-Infective Agents Phase 4
24 Antiemetics Phase 4
25 Antifungal Agents Phase 4
26 Anti-Inflammatory Agents Phase 4
27 Antirheumatic Agents Phase 4
28 BB 1101 Phase 4
29 Autonomic Agents Phase 4
30 Calcineurin Inhibitors Phase 4
31 Antineoplastic Agents, Hormonal Phase 4
32
Hyaluronic acid Approved, Vet_approved Phase 1, Phase 2 9004-61-9 53477741
33
Ranibizumab Approved Phase 2 347396-82-1 459903
34 Adjuvants, Immunologic Phase 1, Phase 2
35 Angiogenesis Inhibitors Phase 2,Phase 1
36 Angiogenesis Modulating Agents Phase 2,Phase 1
37 Viscosupplements Phase 1, Phase 2
38 Protective Agents Phase 1, Phase 2
39
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 1 67-73-2 6215
40 Anecortave Investigational Phase 1 10184-70-0

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine for Vernal Keratoconjunctivitis (VKC) in Rwanda Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2 Provisc
3 The LIMO Study, Lucentis for Treatment of Uveitic Patients With Refractory Cystoid Macular Oedema Completed NCT01564108 Phase 2 Ranibizumab
4 Prophylactic Anecortave Acetate in Patients With a Retisert Implant Completed NCT00570479 Phase 1 anecortave acetate
5 Gene Polymorphisms of Corticosteroid-induced Ocular Hypertension Recruiting NCT03250819

Search NIH Clinical Center for Steroid-Induced Glaucoma

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Genetic Tests for Steroid-Induced Glaucoma

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Anatomical Context for Steroid-Induced Glaucoma

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MalaCards organs/tissues related to Steroid-Induced Glaucoma:

41
Eye
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Publications for Steroid-Induced Glaucoma

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Articles related to Steroid-Induced Glaucoma:

(show top 50) (show all 52)
# Title Authors Year
1
Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma. ( 29850218 )
2018
2
Re: Maleki etA al.: Selective laser trabeculoplasty in controlled uveitis with steroid-induced glaucoma (Ophthalmology. 2016;123:2630-2632). ( 28734340 )
2017
3
Steroid-induced glaucoma in the pediatric population. ( 28087345 )
2017
4
DEX implant intravitreal injection, sustained intraocular hypertension, and steroid-induced glaucoma in patients with no risk factors. ( 28801709 )
2017
5
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness. ( 28924342 )
2017
6
Peripapillary retinoschisis and serous retinal elevation secondary to steroid-induced glaucoma. ( 27521684 )
2016
7
Selective Laser Trabeculoplasty in Controlled Uveitis with Steroid-Induced Glaucoma. ( 27594199 )
2016
8
Inducible scAAV2.GRE.MMP1 lowers IOP long-term in a large animal model for steroid-induced glaucoma gene therapy. ( 26855269 )
2016
9
ExPRESS Mini-Shunt as a Treatment Alternative for Medically Uncontrolled Steroid-Induced Glaucoma in a Pediatric Patient. ( 28101045 )
2016
10
Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma. ( 27341769 )
2016
11
Outcome of primary trabeculotomy ab interno (Trabectome) surgery in patients with steroid-induced glaucoma. ( 27977576 )
2016
12
Steroid-induced glaucoma and childhood blindness. ( 26002945 )
2015
13
Goniotomy for Steroid-Induced Glaucoma: Clinical and Tonographic Evidence to Support Therapeutic Goniotomy. ( 26053210 )
2015
14
Effect of Topical Calcium Channel Blockers on Intraocular Pressure in Steroid-induced Glaucoma. ( 26997802 )
2014
15
Comparison of trabeculectomy with mitomycin-C versus medical treatment in moderate stage of steroid induced glaucoma. ( 23715350 )
2013
16
Effects of thailanstatins on glucocorticoid response in trabecular meshwork and steroid-induced glaucoma. ( 23548621 )
2013
17
Successful trabeculotomy in a patient with corticosteroid-induced glaucoma with anti-aquaporin 4 antibody-positive neuromyelitis optica: a case report. ( 23575376 )
2013
18
Severe vernal keratoconjunctivitis requiring trabeculectomy with mitomycin C for corticosteroid-induced glaucoma. ( 21575117 )
2012
19
Glaukos(Ar) trabecular stent used to treat steroid-induced glaucoma. ( 22970451 )
2012
20
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21396622 )
2011
21
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21855676 )
2011
22
Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort study. ( 21855678 )
2011
23
Steroid-induced glaucoma in children with acute lymphoblastic leukemia: a possible complication. ( 19661822 )
2010
24
Control of steroid-induced glaucoma with surgical excision of sub-Tenon triamcinolone acetonide deposits: a clinical and biochemical approach. ( 20935694 )
2010
25
Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. ( 18386038 )
2008
26
Diagnosis of steroid-induced glaucoma after photorefractive keratectomy. ( 18500094 )
2008
27
Prospective, long-term evaluation of steroid-induced glaucoma. ( 16823461 )
2008
28
Steroid-induced glaucoma in an infant. ( 17629528 )
2007
29
Conservative management of refractory steroid-induced glaucoma following anterior subtenon steroid injection. ( 17362470 )
2007
30
Corneal topographic response to intraocular pressure reduction in patients with vernal keratoconjunctivitis and steroid-induced glaucoma. ( 16273087 )
2007
31
Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide. ( 16490518 )
2006
32
What's your diagnosis? Steroid-induced glaucoma. ( 17022158 )
2006
33
Preventing steroid-induced glaucoma. ( 16009853 )
2005
34
In vivo confocal microscopic findings in patients with steroid-induced glaucoma after LASIK. ( 15051211 )
2004
35
Steroid-induced glaucoma after laser in situ keratomileusis associated with interface fluid. ( 11927421 )
2002
36
Effect of latanoprost on intraocular pressure in steroid-induced glaucoma. ( 10782629 )
2000
37
External trabeculotomy for the treatment of steroid-induced glaucoma. ( 11131756 )
2000
38
Steroid-induced glaucoma in a young woman. ( 9786566 )
1998
39
TIGR gene in primary open-angle glaucoma and steroid-induced glaucoma. ( 9510647 )
1997
40
Steroid induced glaucoma: a report of two cases with a review of morbidity and prescribing in general practice. ( 2374915 )
1990
41
Steroid induced glaucoma and cataract. ( 2807493 )
1989
42
Management of vernal conjunctivitis with steroid induced glaucoma--a comparative study. ( 3150371 )
1987
43
Ophthalmology-important advances in clinical medicine: steroid-induced glaucoma. ( 18749495 )
1984
44
Histopathological and histochemical analysis of trabeculectomy specimens in open angle and steroid induced glaucoma--a clinicopathological study. ( 6544294 )
1983
45
Steroid induced glaucoma. ( 7166423 )
1982
46
Steroid-induced glaucoma and cataract in renal transplant recipients. ( 336581 )
1977
47
Steroid-induced glaucoma: A. Persistent elevation of intraocular pressure B. Histopathological aspects. ( 613525 )
1977
48
Blindness due to steroid induced glaucoma. ( 4393506 )
1969
49
Steroid induced glaucoma (experimental study). ( 5371045 )
1969
50
Medical control of steroid-induced glaucoma: a case report. ( 6039213 )
1967
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Variations for Steroid-Induced Glaucoma

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Expression for Steroid-Induced Glaucoma

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Search GEO for disease gene expression data for Steroid-Induced Glaucoma.
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Pathways for Steroid-Induced Glaucoma

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Pathways related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
RAB GEFs exchange GTP for GDP on RABs 66
10.91 RAB3GAP1 RAB3GAP2
2
COPI-independent Golgi-to-ER retrograde traffic 66
10.07 RAB3GAP1 RAB3GAP2
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GO Terms for Steroid-Induced Glaucoma

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Biological processes related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of GTPase activity GO:0043087 9.4 RAB3GAP1 RAB3GAP2
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.37 DCN MYOC
3 positive regulation of autophagosome assembly GO:2000786 9.32 RAB3GAP1 RAB3GAP2
4 positive regulation of mitochondrial depolarization GO:0051901 9.26 DCN MYOC
5 positive regulation of protein lipidation GO:1903061 9.16 RAB3GAP1 RAB3GAP2
6 positive regulation of endoplasmic reticulum tubular network organization GO:1903373 8.96 RAB3GAP1 RAB3GAP2
7 establishment of protein localization to endoplasmic reticulum membrane GO:0097051 8.62 RAB3GAP1 RAB3GAP2

Molecular functions related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Rab guanyl-nucleotide exchange factor activity GO:0017112 8.62 RAB3GAP1 RAB3GAP2
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Sources for Steroid-Induced Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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