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MCID: STR019
MIFTS: 30

Steroid-Induced Glaucoma

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Steroid-Induced Glaucoma

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MalaCards integrated aliases for Steroid-Induced Glaucoma:

Name: Steroid-Induced Glaucoma 12 15
Corticosteroid-Induced Glaucoma 12 54 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9946
ICD9CM 34 365.3
SNOMED-CT 67 1654001
UMLS 71 C0339578
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Summaries for Steroid-Induced Glaucoma

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Disease Ontology : 12 A glaucoma characterized by elevated intraocular pressure secondary to chronic corticosteroid use, which leads to glaucomatous optic nerve atrophy and progressive vision loss and has symptom progressive decreased vision, visual field defects, and decreased peripheral vision. Steroid-induced glaucoma is caused by chronic corticosteroid use.

MalaCards based summary : Steroid-Induced Glaucoma, also known as corticosteroid-induced glaucoma, is related to glaucoma 1, open angle, a and keratitis, hereditary, and has symptoms including progressive decreased vision An important gene associated with Steroid-Induced Glaucoma is MYOC (Myocilin). The drugs Hyaluronic acid and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and thymus.

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Related Diseases for Steroid-Induced Glaucoma

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Diseases related to Steroid-Induced Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 glaucoma 1, open angle, a 32.0 MYOC CYP1B1
2 keratitis, hereditary 30.3 MYOC CYP1B1 CRYAA
3 ocular hypertension 30.1 TGFB2 NR3C1 MYOC CRYAA
4 optic nerve disease 29.9 WDR36 SERPINA3 MYOC ELN CRYAA
5 intraocular pressure quantitative trait locus 29.8 WDR36 TGFB2 SERPINA3 MYOC ELN CYP1B1
6 eye disease 29.4 TGFB2 SERPINA3 MYOC FN1 CYP1B1 CRYAA
7 cataract 29.3 TGFB2 RAB3GAP2 NR3C1 FN1 CRYAA
8 open-angle glaucoma 28.7 WDR36 TGFB2 NR3C1 MYOC ELN CYP1B1
9 glaucoma, primary open angle 28.6 WDR36 TGFB2 SERPINA3 MYOC FN1 ELN
10 steroid-induced glaucoma - borderline 11.4
11 residual stage corticosteroid-induced glaucoma 11.3
12 keratoconjunctivitis 10.4
13 yemenite deaf-blind hypopigmentation syndrome 10.3
14 uveitis 10.3
15 vernal keratoconjunctivitis 10.3
16 chronic closed-angle glaucoma 10.3 TGFB2 MYOC
17 cone-rod dystrophy, x-linked, 3 10.3 SERPINA3 CRYAA
18 preretinal fibrosis 10.3 TGFB2 FN1
19 retinal perforation 10.2 FN1 CRYAA
20 peripheral retinal degeneration 10.2 WDR36 MYOC
21 neovascular glaucoma 10.2 TGFB2 MYOC CRYAA
22 uveal disease 10.2 SERPINA3 MYOC CRYAA
23 vitreous disease 10.2 TGFB2 FN1 CRYAA
24 macular holes 10.2 TGFB2 FN1 CRYAA
25 vitreoretinopathy, neovascular inflammatory 10.2 TGFB2 FN1 CRYAA
26 traumatic glaucoma 10.2 MYOC CYP1B1
27 early-onset glaucoma 10.2 MYOC CYP1B1
28 conjunctivitis 10.2
29 acute closed-angle glaucoma 10.1 MYOC CYP1B1
30 deafness, autosomal dominant 56 10.1 FN1 COCH
31 weber syndrome 10.1 FN1 CYP1B1
32 allergic conjunctivitis 10.1
33 macular retinal edema 10.1
34 corneal disease 10.1 TGFB2 SERPINA3 FN1 CRYAA
35 cranial nerve disease 10.1 WDR36 SERPINA3 MYOC CRYAA
36 axenfeld-rieger syndrome, type 1 10.0 CYP1B1 CRYAA
37 corneal edema 10.0 MYOC FN1 CYP1B1
38 excessive tearing 10.0 WDR36 MYOC CYP1B1
39 glaucoma-related pigment dispersion syndrome 10.0 WDR36 MYOC CYP1B1
40 microphthalmia, isolated 2 10.0 WDR36 MYOC CYP1B1
41 leber hereditary optic neuropathy, modifier of 10.0 WDR36 MYOC CRYAA
42 hydrophthalmos 10.0 WDR36 MYOC CYP1B1
43 megalocornea 10.0 WDR36 MYOC CYP1B1
44 aniridia 1 10.0 MYOC CYP1B1 CRYAA
45 glaucoma 3, primary congenital, a 10.0 WDR36 MYOC CYP1B1
46 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.0 SERPINA3 FN1 CRYAA
47 arterial tortuosity syndrome 10.0 TGFB2 ELN
48 mitral valve disease 10.0 TGFB2 SERPINA3 ELN
49 atypical depressive disorder 9.9 SERPINA3 NR3C1
50 aortic disease 9.9 TGFB2 SERPINA3 ELN

Graphical network of the top 20 diseases related to Steroid-Induced Glaucoma:



Diseases related to Steroid-Induced Glaucoma
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Symptoms & Phenotypes for Steroid-Induced Glaucoma

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Symptoms:

12
  • • progressive decreased vision
Sources

Drugs & Therapeutics for Steroid-Induced Glaucoma

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Drugs for Steroid-Induced Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 1, Phase 2 9004-61-9 53477741
2 Protective Agents Phase 1, Phase 2
3 Immunologic Factors Phase 1, Phase 2
4 Viscosupplements Phase 1, Phase 2
5 Adjuvants, Immunologic Phase 1, Phase 2
6
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 1 67-73-2 6215
7 Anecortave Investigational Phase 1 10184-70-0
8 Angiogenesis Inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparative Study of the Efficacy and Safety of Ologen Collagen Implant Versus Cohesive Viscoelastic in Trabeculectomy Performed for Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2 Provisc
2 Prevention of Steroid-induced Glaucoma Using Anecortave Acetate Completed NCT00570479 Phase 1 anecortave acetate
3 Viscotrabeculotomy Versus Trabeculectomy With "MMC" for the Management of Medically Uncontrolled Steroid Induced Glaucoma Recruiting NCT04673201

Search NIH Clinical Center for Steroid-Induced Glaucoma

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Genetic Tests for Steroid-Induced Glaucoma

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Anatomical Context for Steroid-Induced Glaucoma

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MalaCards organs/tissues related to Steroid-Induced Glaucoma:

40
Eye, Endothelial, Thymus, Retina
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Publications for Steroid-Induced Glaucoma

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Articles related to Steroid-Induced Glaucoma:

(show top 50) (show all 222)
# Title Authors PMID Year
1
Overexpression of myocilin in cultured human trabecular meshwork cells. 54 61
15194423 2004
2
The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes. 61
33189813 2021
3
Acute Benign Paroxysmal Positional Vertigo After Endothelial Keratoplasty-A Unique Cause of Postoperative Nausea and Headache. 61
33252384 2020
4
Intraocular Pressure Peaks After Suprachoroidal Stent Implantation. 61
32740501 2020
5
Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management. 61
32057761 2020
6
Intraocular pressure-lowering effects of ripasudil in uveitic glaucoma, exfoliation glaucoma, and steroid-induced glaucoma patients: ROCK-S, a multicentre historical cohort study. 61
32587304 2020
7
Role of combined immunomodulator therapy in severe steroid intolerant vernal keratoconjunctivitis. 61
32518397 2020
8
Steroid-induced glaucoma and blindness in vernal keratoconjunctivitis. 61
31055451 2020
9
Efficacy and Safety of High-Energy Selective Laser Trabeculoplasty for Steroid-Induced Glaucoma in Patients with Quiescent Uveitis. 61
31902258 2020
10
Outcomes of Epiretinal Membrane Removal Utilizing Triamcinolone Acetonide Visualization and Internal Limiting Membrane Forceps. 61
33239859 2020
11
Combining Ab Interno Kahook Trabeculectomy with Gonioscopy-Assisted Transluminal Trabeculotomy Reduces Intraocular Pressure. 61
31247075 2019
12
Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies. 61
31489974 2019
13
Case of paediatric steroid-induced glaucoma showing extremely fast progression with deformation of lamina cribrosa. 61
30995695 2019
14
Hypotony maculopathy: a surgeon's nightmare. 61
31712237 2019
15
Pattern of steroid misuse in vernal keratoconjunctivitis resulting in steroid induced glaucoma and visual disability in Indian rural population: An important public health problem in pediatric age group. 61
31546501 2019
16
Gonioscopy-assisted Transluminal Trabeculotomy in a Pediatric Patient With Steroid-induced Glaucoma. 61
31574020 2019
17
Surgical Outcomes of Prolene Gonioscopy-assisted Transluminal Trabeculotomy in Patients With Moderate to Advanced Open-Angle Glaucoma. 61
31385914 2019
18
Suture-Probe Canaloplasty as an Alternative to Canaloplasty Using the iTrack Microcatheter. 61
31283701 2019
19
Gonioscopy-assisted Transluminal Trabeculotomy (GATT) is An Effective Procedure for Steroid-induced Glaucoma. 61
31259756 2019
20
CUSHING DISEASE MASQUERADING AS GLAUCOMA. 61
31967055 2019
21
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
22
In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. 61
30651311 2019
23
Congenital Corneal Opacities Associated With Trisomy 8 Mosaicism Syndrome. 61
30272617 2018
24
Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in Postpenetrating Keratoplasty Steroid-induced Glaucoma: A Case Report. 61
30059406 2018
25
The rescue effect of adalimumab in the treatment of refractory pediatric panuveitis complicated with steroid-induced glaucoma. 61
30294530 2018
26
[Topical Corticosteroids and Non-steroidal Anti-inflammatory Drugs in the Therapy of Non-infectious Uveitis]. 61
29739028 2018
27
The relationship between outflow resistance and trabecular meshwork stiffness in mice. 61
29643342 2018
28
Canaloplasty in Corticosteroid-Induced Glaucoma. Preliminary Results. 61
29439499 2018
29
Clinical Outcomes of Adjunctive Sustained-Release Intravitreal Dexamethasone Implants in Tuberculosis-Associated Multifocal Serpigenoid Choroiditis. 61
29020496 2018
30
Case series of children with steroid-Induced glaucoma. 61
30800232 2018
31
DEX implant intravitreal injection, sustained intraocular hypertension, and steroid-induced glaucoma in patients with no risk factors. 61
28801709 2018
32
Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma. 61
29850218 2018
33
Patch Grafting Using an Ologen Collagen Matrix to Manage Tubal Exposure in Glaucoma Tube Shunt Surgery. 61
29643776 2018
34
Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone. 61
29499052 2018
35
Uveal effusion syndrome in 104 eyes: Response to corticosteroids - The 2017 Axel C. Hansen lecture. 61
29133632 2017
36
Re: Maleki et al.: Selective laser trabeculoplasty in controlled uveitis with steroid-induced glaucoma (Ophthalmology. 2016;123:2630-2632). 61
28734340 2017
37
Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells. 61
28526237 2017
38
Trabeculectomy or Transscleral Cyclophotocoagulation as Initial Treatment of Secondary Childhood Glaucoma in Northern Tanzania. 61
28448293 2017
39
A Review of Selective Laser Trabeculoplasty: Recent Findings and Current Perspectives. 61
28258400 2017
40
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness. 61
28924342 2017
41
Persistent Epithelial Defects and Corneal Opacity After Collagen Cross-Linking With Substitution of Dextran (T-500) With Dextran Sulfate in Compounded Topical Riboflavin. 61
28129292 2017
42
Rodent models of glaucoma and their applicability for drug discovery. 61
28075618 2017
43
Steroid-induced glaucoma in the pediatric population. 61
28087345 2017
44
[Steroid-Induced Glaucoma as a Complication of Atopic Eczema Local Treatment]. 61
28931299 2017
45
FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25. 61
28575017 2017
46
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. 61
27666015 2017
47
SUBRETINAL CANNULATION AS A COMPLICATION OF SUTURE TRABECULOTOMY SURGERY IN A PEDIATRIC PATIENT. 61
26967964 2017
48
[Cortisol levels in plasma and aqueous humour of patients with steroid induced and other glaucomas]. 61
28524138 2017
49
Selective Laser Trabeculoplasty in Controlled Uveitis with Steroid-Induced Glaucoma. 61
27594199 2016
50
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. 61
26961753 2016
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Variations for Steroid-Induced Glaucoma

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Expression for Steroid-Induced Glaucoma

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Search GEO for disease gene expression data for Steroid-Induced Glaucoma.
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Pathways for Steroid-Induced Glaucoma

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GO Terms for Steroid-Induced Glaucoma

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Cellular components related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.17 TGFB2 SERPINA3 MYOC FN1 ELN COCH
2 platelet alpha granule lumen GO:0031093 9.13 TGFB2 SERPINA3 FN1

Biological processes related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.33 TGFB2 SERPINA3 FN1
2 stress fiber assembly GO:0043149 8.96 PDLIM1 ELN
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 TGFB2 MYOC FN1
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Sources for Steroid-Induced Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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