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MCID: STR019
MIFTS: 32

Steroid-Induced Glaucoma

Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Steroid-Induced Glaucoma

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MalaCards integrated aliases for Steroid-Induced Glaucoma:

Name: Steroid-Induced Glaucoma 12 15
Corticosteroid-Induced Glaucoma 12 54 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9946
ICD9CM 34 365.3
SNOMED-CT 67 1654001
UMLS 71 C0339578
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Summaries for Steroid-Induced Glaucoma

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Disease Ontology : 12 A glaucoma characterized by elevated intraocular pressure secondary to chronic corticosteroid use, which leads to glaucomatous optic nerve atrophy and progressive vision loss and has symptom progressive decreased vision, visual field defects, and decreased peripheral vision. Steroid-induced glaucoma is caused by chronic corticosteroid use.

MalaCards based summary : Steroid-Induced Glaucoma, also known as corticosteroid-induced glaucoma, is related to glaucoma 1, open angle, a and open-angle glaucoma, and has symptoms including progressive decreased vision An important gene associated with Steroid-Induced Glaucoma is MYOC (Myocilin). The drugs Clotrimazole and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and thymus.

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Related Diseases for Steroid-Induced Glaucoma

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Diseases related to Steroid-Induced Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 glaucoma 1, open angle, a 32.5 OPTN MYOC
2 open-angle glaucoma 30.2 WDR36 TGFB2 OPTN MYOC CRYAA
3 intraocular pressure quantitative trait locus 30.2 WDR36 TGFB2 SERPINA3 PEX19 OPTN MYOC
4 optic nerve disease 29.9 WDR36 SERPINA3 OPTN MYOC CRYAA
5 ocular hypertension 29.5 WDR36 TGFB2 OPTN NR3C1 MYOC CRYAA
6 cataract 29.4 TGFB2 RAB3GAP2 NR3C1 FN1 CRYAA
7 eye disease 29.1 TGFB2 SERPINA3 OPTN MYOC FN1 CRYAA
8 glaucoma, primary open angle 28.8 WDR36 TMTC1 TGFB2 SERPINA3 PEX19 OPTN
9 steroid-induced glaucoma - borderline 12.6
10 residual stage corticosteroid-induced glaucoma 12.6
11 keratoconjunctivitis 10.4
12 cone-rod dystrophy, x-linked, 3 10.4 SERPINA3 CRYAA
13 preretinal fibrosis 10.3 TGFB2 FN1
14 vernal keratoconjunctivitis 10.3
15 morgagni cataract 10.3 PEX19 CRYAA
16 hydrophthalmos 10.3 WDR36 MYOC
17 peripheral retinal degeneration 10.3 WDR36 MYOC
18 mature cataract 10.3 PEX19 CRYAA
19 yemenite deaf-blind hypopigmentation syndrome 10.3
20 retinal perforation 10.3 FN1 CRYAA
21 uveitis 10.3
22 microphthalmia, isolated 2 10.3 WDR36 MYOC
23 vitreous disease 10.2 TGFB2 FN1 CRYAA
24 macular holes 10.2 TGFB2 FN1 CRYAA
25 axenfeld-rieger syndrome 10.2 WDR36 MYOC CRYAA
26 atypical depressive disorder 10.2 SERPINA3 NR3C1
27 chronic closed-angle glaucoma 10.2 TGFB2 PEX19 MYOC
28 phimosis 10.2 PEX19 CRYAA
29 giant cell reparative granuloma 10.2 SERPINA3 NR3C1
30 neovascular glaucoma 10.2 TGFB2 PEX19 CRYAA
31 uveal disease 10.2 SERPINA3 PEX19 CRYAA
32 keratitis, hereditary 10.2
33 conjunctivitis 10.2
34 renal infectious disease 10.1 NR3C1 NLRC4
35 amyotrophic lateral sclerosis 12 10.1 OPTN CRYAA
36 corneal disease 10.1 TGFB2 SERPINA3 FN1 CRYAA
37 macular dystrophy, dominant cystoid 10.1 PEX19 CRYAA
38 allergic conjunctivitis 10.1
39 macular retinal edema 10.1
40 lens disease 10.0 SERPINA3 PEX19 MYOC CRYAA
41 amyotrophic lateral sclerosis 9 10.0 OPTN CRYAA
42 leber optic atrophy 10.0 WDR36 MYOC CRYAA
43 glaucoma 3, primary congenital, a 10.0 WDR36 OPTN MYOC
44 acute closed-angle glaucoma 10.0 PEX19 OPTN MYOC
45 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 10.0 SERPINA3 FN1 CRYAA
46 microvascular complications of diabetes 5 10.0 THBS1 TGFB2 CRYAA
47 myopia 10.0 WDR36 TGFB2 MYOC CRYAA
48 vitiligo-associated multiple autoimmune disease susceptibility 6 9.9
49 dermatitis, atopic 9.9
50 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9

Graphical network of the top 20 diseases related to Steroid-Induced Glaucoma:



Diseases related to Steroid-Induced Glaucoma
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Symptoms & Phenotypes for Steroid-Induced Glaucoma

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Symptoms:

12
  • • progressive decreased vision
Sources

Drugs & Therapeutics for Steroid-Induced Glaucoma

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Drugs for Steroid-Induced Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
5 Immunologic Factors Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Hormones Phase 4
10 Anti-Infective Agents Phase 4
11 Antiemetics Phase 4
12 Cyclosporins Phase 4
13 Hormone Antagonists Phase 4
14 Immunosuppressive Agents Phase 4
15 Dermatologic Agents Phase 4
16 glucocorticoids Phase 4
17 Ophthalmic Solutions Phase 4
18 Antifungal Agents Phase 4
19 Calcineurin Inhibitors Phase 4
20 Antirheumatic Agents Phase 4
21
Hyaluronic acid Approved, Vet_approved Phase 1, Phase 2 9004-61-9 53477741
22
Hydrocortisone Approved, Vet_approved Phase 1, Phase 2 50-23-7 5754
23
Hydrocortisone acetate Approved, Vet_approved Phase 1, Phase 2 50-03-3
24 Anecortave Investigational Phase 1, Phase 2 10184-70-0
25 Viscosupplements Phase 1, Phase 2
26 Adjuvants, Immunologic Phase 1, Phase 2
27 Protective Agents Phase 1, Phase 2
28 Hydrocortisone 17-butyrate 21-propionate Phase 1, Phase 2
29 Hydrocortisone hemisuccinate Phase 1, Phase 2
30 Angiogenesis Inhibitors Phase 1, Phase 2
31
Adalimumab Approved Phase 1 331731-18-1 16219006
32
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 1 67-73-2 6215

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Cyclosporine in the Treatment of Vernal Keratoconjunctivitis in a Rwandan Eye Clinic; a Prospective Randomized Double-masked Clinical Trial Completed NCT01211327 Phase 4 Cyclosporine A;Dexamethasone
2 Comparative Study of the Efficacy and Safety of Ologen Collagen Implant Versus Cohesive Viscoelastic in Trabeculectomy Performed for Steroid Induced Glaucoma Completed NCT01912638 Phase 1, Phase 2 Provisc
3 Treatment of Chronic Central Serous Chorioretinopathy With Open-label Anecortave Acetate Completed NCT00489840 Phase 1, Phase 2 Anecortave Acetate Sterile suspension 15 mg;Anecortave Acetate
4 The Safety and Tolerability of Intravitreal Adalimumab in Patients With Refractory Diabetic Macular Retinopathy or Choroidal Neovascularization or Uveitis: A Pilot Study Unknown status NCT00855608 Phase 1 adalimumab
5 Prevention of Steroid-induced Glaucoma Using Anecortave Acetate Completed NCT00570479 Phase 1 anecortave acetate
6 Corneal Endothelial Cell Loss After Trabeculectomy Versus Combined Trabeculectomy Phakoemulsification and IOL Implantation Unknown status NCT03107000
7 Genetic Association Study on Corticosteroid-induced Elevation of the Intraocular Pressure Completed NCT03250819
8 Exploring Immune Cell Signatures in Autoimmunity and Ocular Surface Stress Recruiting NCT02715323

Search NIH Clinical Center for Steroid-Induced Glaucoma

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Genetic Tests for Steroid-Induced Glaucoma

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Anatomical Context for Steroid-Induced Glaucoma

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MalaCards organs/tissues related to Steroid-Induced Glaucoma:

40
Eye, Endothelial, Thymus, Retina, Kidney
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Publications for Steroid-Induced Glaucoma

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Articles related to Steroid-Induced Glaucoma:

(show top 50) (show all 218)
# Title Authors PMID Year
1
Overexpression of myocilin in cultured human trabecular meshwork cells. 54 61
15194423 2004
2
Steroid-induced glaucoma: Epidemiology, pathophysiology, and clinical management. 61
32057761 2020
3
Role of combined immunomodulator therapy in severe steroid intolerant vernal keratoconjunctivitis. 61
32518397 2020
4
Steroid-induced glaucoma and blindness in vernal keratoconjunctivitis. 61
31055451 2020
5
Efficacy and Safety of High-Energy Selective Laser Trabeculoplasty for Steroid-Induced Glaucoma in Patients with Quiescent Uveitis. 61
31902258 2020
6
Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies. 61
31489974 2019
7
Combining Ab Interno Kahook Trabeculectomy with Gonioscopy-Assisted Transluminal Trabeculotomy Reduces Intraocular Pressure. 61
31247075 2019
8
Hypotony maculopathy: a surgeon's nightmare. 61
31712237 2019
9
Case of paediatric steroid-induced glaucoma showing extremely fast progression with deformation of lamina cribrosa. 61
30995695 2019
10
Gonioscopy-assisted Transluminal Trabeculotomy in a Pediatric Patient With Steroid-induced Glaucoma. 61
31574020 2019
11
Surgical Outcomes of Prolene Gonioscopy-assisted Transluminal Trabeculotomy in Patients With Moderate to Advanced Open-Angle Glaucoma. 61
31385914 2019
12
Pattern of steroid misuse in vernal keratoconjunctivitis resulting in steroid induced glaucoma and visual disability in Indian rural population: An important public health problem in pediatric age group. 61
31546501 2019
13
Suture-Probe Canaloplasty as an Alternative to Canaloplasty Using the iTrack Microcatheter. 61
31283701 2019
14
CUSHING DISEASE MASQUERADING AS GLAUCOMA. 61
31967055 2019
15
Gonioscopy-assisted Transluminal Trabeculotomy (GATT) is An Effective Procedure for Steroid-induced Glaucoma. 61
31259756 2019
16
Gonioscopy-assisted Transluminal Trabebeculotomy in a Pediatric Patient with Steroid-induced Glaucoma. 61
31306363 2019
17
[Application of corticosteroid eye drops for allergic eye diseases in children]. 61
30798620 2019
18
In vivo measurement of trabecular meshwork stiffness in a corticosteroid-induced ocular hypertensive mouse model. 61
30651311 2019
19
Congenital Corneal Opacities Associated With Trisomy 8 Mosaicism Syndrome. 61
30272617 2018
20
Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in Postpenetrating Keratoplasty Steroid-induced Glaucoma: A Case Report. 61
30059406 2018
21
The rescue effect of adalimumab in the treatment of refractory pediatric panuveitis complicated with steroid-induced glaucoma. 61
30294530 2018
22
[Topical Corticosteroids and Non-steroidal Anti-inflammatory Drugs in the Therapy of Non-infectious Uveitis]. 61
29739028 2018
23
The relationship between outflow resistance and trabecular meshwork stiffness in mice. 61
29643342 2018
24
Canaloplasty in Corticosteroid-Induced Glaucoma. Preliminary Results. 61
29439499 2018
25
Case series of children with steroid-Induced glaucoma. 61
30800232 2018
26
Outcome of Primary Nonpenetrating Deep Sclerectomy in Patients with Steroid-Induced Glaucoma. 61
29850218 2018
27
Patch Grafting Using an Ologen Collagen Matrix to Manage Tubal Exposure in Glaucoma Tube Shunt Surgery. 61
29643776 2018
28
Clinical Outcomes of Adjunctive Sustained-Release Intravitreal Dexamethasone Implants in Tuberculosis-Associated Multifocal Serpigenoid Choroiditis. 61
29020496 2018
29
DEX implant intravitreal injection, sustained intraocular hypertension, and steroid-induced glaucoma in patients with no risk factors. 61
28801709 2018
30
Absence of a secondary glucocorticoid response in C57BL/6J mice treated with topical dexamethasone. 61
29499052 2018
31
Uveal effusion syndrome in 104 eyes: Response to corticosteroids - The 2017 Axel C. Hansen lecture. 61
29133632 2017
32
Small-molecule inhibition of Wnt signaling abrogates dexamethasone-induced phenotype of primary human trabecular meshwork cells. 61
28526237 2017
33
Re: Maleki et al.: Selective laser trabeculoplasty in controlled uveitis with steroid-induced glaucoma (Ophthalmology. 2016;123:2630-2632). 61
28734340 2017
34
Trabeculectomy or Transscleral Cyclophotocoagulation as Initial Treatment of Secondary Childhood Glaucoma in Northern Tanzania. 61
28448293 2017
35
A Review of Selective Laser Trabeculoplasty: Recent Findings and Current Perspectives. 61
28258400 2017
36
Steroid-induced Glaucoma: An Avoidable Irreversible Blindness. 61
28924342 2017
37
Persistent Epithelial Defects and Corneal Opacity After Collagen Cross-Linking With Substitution of Dextran (T-500) With Dextran Sulfate in Compounded Topical Riboflavin. 61
28129292 2017
38
Rodent models of glaucoma and their applicability for drug discovery. 61
28075618 2017
39
Steroid-induced glaucoma in the pediatric population. 61
28087345 2017
40
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine. 61
27666015 2017
41
[Steroid-Induced Glaucoma as a Complication of Atopic Eczema Local Treatment]. 61
28931299 2017
42
FOXC1 modulates MYOC secretion through regulation of the exocytic proteins RAB3GAP1, RAB3GAP2 and SNAP25. 61
28575017 2017
43
SUBRETINAL CANNULATION AS A COMPLICATION OF SUTURE TRABECULOTOMY SURGERY IN A PEDIATRIC PATIENT. 61
26967964 2017
44
[Cortisol levels in plasma and aqueous humour of patients with steroid induced and other glaucomas]. 61
28524138 2017
45
Vernal Keratoconjunctivitis in Kashmir: A temperate zone. 61
26961753 2016
46
Steroid-induced glaucoma treated with trabecular ablation in a matched comparison with primary open-angle glaucoma. 61
27341769 2016
47
Outcome of primary trabeculotomy ab interno (Trabectome) surgery in patients with steroid-induced glaucoma. 61
27977576 2016
48
Selective Laser Trabeculoplasty in Controlled Uveitis with Steroid-Induced Glaucoma. 61
27594199 2016
49
Topical difluprednate for the treatment of retinal vasculitis associated with birdshot chorioretinitis. 61
29503901 2016
50
ExPRESS Mini-Shunt as a Treatment Alternative for Medically Uncontrolled Steroid-Induced Glaucoma in a Pediatric Patient. 61
28101045 2016
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Variations for Steroid-Induced Glaucoma

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Expression for Steroid-Induced Glaucoma

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Search GEO for disease gene expression data for Steroid-Induced Glaucoma.
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Pathways for Steroid-Induced Glaucoma

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GO Terms for Steroid-Induced Glaucoma

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Cellular components related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 9.26 THBS1 TGFB2 SERPINA3 FN1
2 fibrinogen complex GO:0005577 9.16 THBS1 FN1
3 collagen-containing extracellular matrix GO:0062023 9.1 THBS1 TGFB2 SERPINA3 MYOC FN1 ANGPTL7

Biological processes related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide cross-linking GO:0018149 9.16 THBS1 FN1
2 negative regulation of cell-matrix adhesion GO:0001953 8.96 THBS1 MYOC
3 platelet degranulation GO:0002576 8.92 THBS1 TGFB2 SERPINA3 FN1

Molecular functions related to Steroid-Induced Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 THBS1 OPTN NLRC4 FN1 CRYAA ANGPTL7
2 protein binding GO:0005515 9.53 WDR36 TMTC1 THBS1 TGFB2 SERPINA3 RAB3GAP2
3 fibronectin binding GO:0001968 9.26 THBS1 MYOC
4 proteoglycan binding GO:0043394 8.96 THBS1 FN1
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Sources for Steroid-Induced Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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