MCID: STC016
MIFTS: 27

Sticky Platelet Syndrome

Categories: Rare diseases, Blood diseases

Aliases & Classifications for Sticky Platelet Syndrome

MalaCards integrated aliases for Sticky Platelet Syndrome:

Name: Sticky Platelet Syndrome 53

Classifications:



Summaries for Sticky Platelet Syndrome

MalaCards based summary : Sticky Platelet Syndrome is related to livedoid vasculopathy and patent foramen ovale. An important gene associated with Sticky Platelet Syndrome is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 76 Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was... more...

Related Diseases for Sticky Platelet Syndrome

Diseases related to Sticky Platelet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 livedoid vasculopathy 30.1 F5 SERPINE1
2 patent foramen ovale 29.7 F5 SERPINC1
3 protein s deficiency 29.6 F5 SERPINC1
4 thrombophilia 29.1 F5 SERPINC1 SERPINE1
5 thrombosis 29.0 F5 SERPINC1 SERPINE1
6 thrombophilia due to thrombin defect 28.9 F5 SERPINC1 SERPINE1
7 pulmonary embolism 28.9 F5 SERPINC1 SERPINE1
8 thrombocytopenic purpura, autoimmune 10.3 GP6 ITGB3
9 arteritic anterior ischemic optic neuropathy 10.2 F5 ITGB3
10 inferior vena cava interruption 10.2 F5 SERPINE1
11 amaurosis fugax 10.2 F5 SERPINE1
12 catastrophic antiphospholipid syndrome 10.2 F5 SERPINE1
13 cryptogenic cirrhosis 10.2 F5 SERPINE1
14 thrombasthenia 10.2 F5 ITGB3
15 factor xiii deficiency 10.2 F5 SERPINE1
16 quebec platelet disorder 10.1 F5 SERPINE1
17 infective endocarditis 10.0 ITGB3 SERPINE1
18 spinal cord infarction 10.0 F5 SERPINC1
19 prothrombin deficiency, congenital 10.0 F5 SERPINC1
20 sagittal sinus thrombosis 10.0 F5 SERPINC1
21 ischemic colitis 10.0 F5 SERPINC1
22 sneddon syndrome 9.9 F5 SERPINC1
23 intracranial thrombosis 9.9 F5 SERPINC1
24 retinal vascular occlusion 9.9 F5 SERPINC1
25 prothrombin deficiency 9.9 F5 SERPINC1
26 antithrombin iii deficiency 9.9 F5 SERPINC1
27 peripheral vertigo 9.9 F5 SERPINC1
28 central retinal vein occlusion 9.9 F5 SERPINC1
29 factor xii deficiency 9.9 F5 SERPINC1
30 dysfibrinogenemia 9.9 F5 SERPINC1
31 inherited blood coagulation disease 9.9 ITGB3 SERPINC1
32 vein disease 9.8 F5 SERPINC1
33 placental abruption 9.8 F5 SERPINC1
34 hemorrhagic fever 9.8 ITGB3 SERPINC1
35 protein c deficiency 9.8 F5 SERPINC1
36 fibrinolytic defect 9.8 SERPINC1 SERPINE1
37 factor x deficiency 9.8 F5 SERPINC1
38 argentine hemorrhagic fever 9.8 SERPINC1 SERPINE1
39 nonarteritic anterior ischemic optic neuropathy 9.8 F5 SERPINC1
40 blue toe syndrome 9.8 SERPINC1 SERPINE1
41 placenta disease 9.8 F5 SERPINC1
42 subendocardial myocardial infarction 9.8 SERPINC1 SERPINE1
43 angina pectoris 9.7 SERPINC1 SERPINE1
44 severe pre-eclampsia 9.7 F5 SERPINC1
45 budd-chiari syndrome 9.7 F5 SERPINC1
46 homocysteinemia 9.7 F5 SERPINC1
47 hepatic vascular disease 9.7 SERPINC1 SERPINE1
48 varicose veins 9.7 F5 SERPINC1
49 hepatic veno-occlusive disease 9.7 SERPINC1 SERPINE1
50 antiphospholipid syndrome 9.6 F5 SERPINC1

Graphical network of the top 20 diseases related to Sticky Platelet Syndrome:



Diseases related to Sticky Platelet Syndrome

Symptoms & Phenotypes for Sticky Platelet Syndrome

MGI Mouse Phenotypes related to Sticky Platelet Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 GAS6 GP6 ITGB3 PEAR1 SERPINC1 SERPINE1
2 cardiovascular system MP:0005385 9.72 F5 GAS6 ITGB3 SERPINC1 SERPINE1
3 homeostasis/metabolism MP:0005376 9.7 F5 GAS6 GP6 ITGB3 PEAR1 SERPINC1
4 liver/biliary system MP:0005370 9.26 SERPINE1 F5 ITGB3 SERPINC1
5 renal/urinary system MP:0005367 8.92 GAS6 ITGB3 SERPINC1 SERPINE1

Drugs & Therapeutics for Sticky Platelet Syndrome

Search Clinical Trials , NIH Clinical Center for Sticky Platelet Syndrome

Genetic Tests for Sticky Platelet Syndrome

Anatomical Context for Sticky Platelet Syndrome

Publications for Sticky Platelet Syndrome

Articles related to Sticky Platelet Syndrome:

(show all 25)
# Title Authors Year
1
Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss. ( 29850310 )
2018
2
Progress in the Understanding of Sticky Platelet Syndrome. ( 27299808 )
2017
3
Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in People with Sticky Platelet Syndrome. ( 28179211 )
2017
4
GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. ( 28041267 )
2016
5
Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. ( 26567442 )
2016
6
Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. ( 26308704 )
2015
7
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. ( 25703520 )
2015
8
The sticky platelet syndrome during carotid endarterectomy. ( 26032011 )
2015
9
Livedoid vasculopathy (LV) associated with sticky platelets syndrome type 3 (SPS type 3) and enhanced activity of plasminogen activator inhibitor (PAI-1) anomalies. ( 25131360 )
2014
10
Comment on Sticky platelet syndrome. ( 24500576 )
2014
11
Sticky platelet syndrome: history and future perspectives. ( 24911675 )
2014
12
Nine kindreds of familial sticky platelet syndrome phenotype. ( 22431856 )
2013
13
Sticky platelets syndrome in a young patient with massive pulmonary embolism. ( 23826459 )
2013
14
The sticky platelet syndrome. ( 23433500 )
2013
15
Primary Thrombophilia in Mexico X: A Prospective Study of the Treatment of the Sticky Platelet Syndrome. ( 24057395 )
2013
16
Sticky platelet syndrome in patients with uninduced venous thrombosis. ( 24385753 )
2013
17
Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. ( 22751911 )
2013
18
Sticky platelet syndrome. ( 23934738 )
2013
19
Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. ( 22821001 )
2012
20
The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. ( 23168074 )
2012
21
Are the platelets activated in sticky platelet syndrome? ( 21450332 )
2011
22
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. ( 21716756 )
2011
23
Is Gas6 protein associated with sticky platelet syndrome? ( 19696043 )
2010
24
Primary thrombophilia in Mexico III: A prospective study of the sticky platelet syndrome. ( 12361206 )
2002
25
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. ( 9973658 )
1999

Variations for Sticky Platelet Syndrome

Expression for Sticky Platelet Syndrome

Search GEO for disease gene expression data for Sticky Platelet Syndrome.

Pathways for Sticky Platelet Syndrome

GO Terms for Sticky Platelet Syndrome

Cellular components related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.13 F5 GAS6 SERPINC1
2 platelet alpha granule lumen GO:0031093 8.8 F5 GAS6 SERPINE1

Biological processes related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.69 F5 GAS6 SERPINC1
2 cellular protein metabolic process GO:0044267 9.63 F5 GAS6 SERPINC1
3 leukocyte migration GO:0050900 9.61 GAS6 GP6 ITGB3
4 viral entry into host cell GO:0046718 9.52 GAS6 ITGB3
5 platelet aggregation GO:0070527 9.49 GAS6 ITGB3
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.48 GAS6 SERPINE1
7 platelet activation GO:0030168 9.43 GAS6 GP6 ITGB3
8 apoptotic cell clearance GO:0043277 9.4 GAS6 ITGB3
9 cell-substrate adhesion GO:0031589 9.37 GAS6 ITGB3
10 hemostasis GO:0007599 9.33 F5 GP6 SERPINC1
11 enzyme linked receptor protein signaling pathway GO:0007167 9.32 GAS6 GP6
12 platelet degranulation GO:0002576 9.26 F5 GAS6 ITGB3 SERPINE1
13 blood coagulation GO:0007596 9.02 F5 GAS6 GP6 ITGB3 SERPINC1

Molecular functions related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 ITGB3 SERPINC1 SERPINE1

Sources for Sticky Platelet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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