MCID: STC016
MIFTS: 24

Sticky Platelet Syndrome

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Sticky Platelet Syndrome

MalaCards integrated aliases for Sticky Platelet Syndrome:

Name: Sticky Platelet Syndrome 20

Classifications:



Summaries for Sticky Platelet Syndrome

MalaCards based summary : Sticky Platelet Syndrome is related to blood platelet disease and thrombophilia due to thrombin defect. An important gene associated with Sticky Platelet Syndrome is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include spinal cord and placenta, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was... more...

Related Diseases for Sticky Platelet Syndrome

Diseases related to Sticky Platelet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 blood platelet disease 29.9 SERPINC1 ITGB3 GP6
2 thrombophilia due to thrombin defect 29.9 SERPINE1 SERPINC1 F5
3 thrombophilia 29.9 SERPINE1 SERPINC1 ITGB3 F5
4 livedoid vasculitis 29.8 SERPINE1 SERPINC1
5 protein s deficiency 29.8 SERPINC1 F5
6 thrombophilia due to activated protein c resistance 29.7 SERPINE1 SERPINC1 F5
7 placenta disease 29.6 SERPINC1 F5
8 carotid artery thrombosis 29.5 SERPINE1 SERPINC1 GP6
9 patent foramen ovale 29.4 SERPINE1 SERPINC1 F5
10 pulmonary embolism 29.4 SERPINE1 SERPINC1 GP6 F5
11 thrombosis 29.3 SERPINE1 SERPINC1 ITGB3 GP6 F5
12 optic nerve disease 10.3
13 neuropathy 10.1
14 amaurosis fugax 10.1 SERPINE1 F5
15 aspirin resistance 10.1 ITGB3 F5
16 sudden sensorineural hearing loss 10.1 ITGB3 F5
17 catastrophic antiphospholipid syndrome 10.1 SERPINE1 F5
18 arteritic anterior ischemic optic neuropathy 10.1 ITGB3 F5
19 cryptogenic cirrhosis 10.1 SERPINE1 F5
20 thrombocytopenic purpura, autoimmune 10.1 ITGB3 GP6
21 thrombasthenia 10.0 ITGB3 F5
22 quebec platelet disorder 10.0 SERPINE1 F5
23 venous insufficiency 10.0 SERPINE1 F5
24 glanzmann thrombasthenia 1 10.0 ITGB3 GP6
25 angina pectoris 10.0
26 limb ischemia 10.0
27 transient cerebral ischemia 10.0
28 ischemia 10.0
29 infertility 10.0
30 infective endocarditis 10.0 SERPINE1 ITGB3
31 spinal cord infarction 9.9 SERPINC1 F5
32 vitamin k deficiency bleeding 9.9 SERPINC1 GAS6
33 prothrombin deficiency, congenital 9.9 SERPINC1 F5
34 sagittal sinus thrombosis 9.9 SERPINC1 F5
35 sneddon syndrome 9.9 SERPINC1 F5
36 fibrinolytic defect 9.9 SERPINE1 SERPINC1
37 peripheral vertigo 9.9 SERPINC1 F5
38 purpura fulminans 9.9 SERPINC1 F5
39 retinal vascular occlusion 9.9 SERPINC1 F5
40 dysfibrinogenemia, congenital 9.9 SERPINC1 F5
41 dic in newborn 9.9 SERPINE1 SERPINC1
42 central retinal vein occlusion 9.9 SERPINC1 F5
43 antithrombin iii deficiency 9.9 SERPINC1 F5
44 factor xii deficiency 9.9 SERPINC1 F5
45 argentine hemorrhagic fever 9.9 SERPINE1 SERPINC1
46 factor xi deficiency 9.9 SERPINC1 F5
47 purpura 9.9 SERPINC1 ITGB3
48 placental abruption 9.8 SERPINC1 F5
49 factor viii deficiency 9.8 SERPINC1 F5
50 hepatic vascular disease 9.8 SERPINE1 SERPINC1

Graphical network of the top 20 diseases related to Sticky Platelet Syndrome:



Diseases related to Sticky Platelet Syndrome

Symptoms & Phenotypes for Sticky Platelet Syndrome

MGI Mouse Phenotypes related to Sticky Platelet Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 GAS6 GP6 ITGB3 PEAR1 SERPINC1 SERPINE1
2 homeostasis/metabolism MP:0005376 9.17 F5 GAS6 GP6 ITGB3 PEAR1 SERPINC1

Drugs & Therapeutics for Sticky Platelet Syndrome

Search Clinical Trials , NIH Clinical Center for Sticky Platelet Syndrome

Genetic Tests for Sticky Platelet Syndrome

Anatomical Context for Sticky Platelet Syndrome

MalaCards organs/tissues related to Sticky Platelet Syndrome:

40
Spinal Cord, Placenta

Publications for Sticky Platelet Syndrome

Articles related to Sticky Platelet Syndrome:

(show top 50) (show all 68)
# Title Authors PMID Year
1
Possible association between haemostasis dysfunction and early onset of microvascular complications in patients with type 1 diabetes. 61
32564584 2020
2
MicroRNA and hyperaggregability of platelets in women with sticky platelet syndrome and pregnancy complications. 61
32955900 2020
3
High Prevalence of Sticky Platelet Syndrome in Patients with Infertility and Pregnancy Loss. 61
31466364 2019
4
Primary Thrombophilia XIV: Worldwide Identification of Sticky Platelet Syndrome. 61
31041794 2019
5
Sticky Platelet Syndrome: 35 Years of Growing Evidence. 61
30630207 2019
6
Commentary: Controversies in Thrombosis and Hemostasis Part 2-Does Sticky Platelet Syndrome Exist? 61
30630203 2019
7
Primary Thrombophilia in Mexico XIII: Localization of the Thrombotic Events in Mexican Mestizos With the Sticky Platelet Syndrome. 61
30968703 2019
8
Glycoprotein VI Gene Variants Affect Pregnancy Loss in Patients With Platelet Hyperaggregability. 61
30278775 2018
9
Association of Genetic Variability in Selected Genes in Patients With Deep Vein Thrombosis and Platelet Hyperaggregability. 61
29865896 2018
10
Rare thrombophilic conditions. 61
30306081 2018
11
Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss. 61
29850310 2018
12
GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. 61
28041267 2018
13
Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in People with Sticky Platelet Syndrome. 61
28179211 2017
14
Progress in the Understanding of Sticky Platelet Syndrome. 61
27299808 2017
15
Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. 61
26567442 2016
16
Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. 61
26308704 2015
17
The sticky platelet syndrome during carotid endarterectomy. 61
26032011 2015
18
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. 61
25703520 2015
19
Platelet Hyperaggregability is Highly Prevalent in Patients With Chronic Kidney Disease: An Underestimated Risk Indicator of Thromboembolic Events. 61
23728835 2015
20
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. 61
24057395 2015
21
Decreased Threshold of Aggregation to Low-Dose Epinephrine is Evidence of Platelet Hyperaggregability in Patients with Thrombosis. 61
25317317 2014
22
Sticky platelet syndrome: history and future perspectives. 61
24911675 2014
23
Response to "Comment on Sticky platelet syndrome". 61
24497123 2014
24
Comment on Sticky platelet syndrome. 61
24500576 2014
25
Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. 61
22751911 2013
26
Sticky platelet syndrome. 61
23934738 2013
27
Nine kindreds of familial sticky platelet syndrome phenotype. 61
22431856 2013
28
The sticky platelet syndrome. 61
23433500 2013
29
Sticky platelet syndrome in patients with uninduced venous thrombosis. 61
24385753 2013
30
[Experience with outpatient treatment for thromboses and thrombophilias]. 61
24640667 2013
31
Platelet aggregation abnormalities in patients with fetal losses: the GP6 gene polymorphism. 61
22901851 2012
32
The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. 61
23168074 2012
33
Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. 61
22821001 2012
34
Are the platelets activated in sticky platelet syndrome? 61
21450332 2011
35
Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. 61
21252804 2011
36
Hypercoagulable state in a patient with a retinal vein occlusion. 61
25389688 2011
37
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. 61
21716756 2011
38
Is Gas6 protein associated with sticky platelet syndrome? 61
19696043 2010
39
Sticky platelet syndrome as a possible cause for free flap failure--a case report. 61
20238381 2010
40
Sticky platelet syndrome: an unusual presentation of arterial ischemia. 61
20363102 2010
41
Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. 61
18662911 2009
42
Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. 61
18995884 2009
43
Inherited trombophilic states and pulmonary embolism. 61
21772860 2009
44
Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. 61
18093268 2008
45
Sticky platelet syndrome and anterior ischaemic optic neuropathy. 61
17997790 2007
46
[Primary thrombophilia in México. VI: lack of statistical association among the inherited thrombophilic conditions]. 61
17969840 2007
47
Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. 61
17532753 2007
48
Transient visual loss triggered by scuba diving in a patient with a petrous epidermoid and combined thrombotic risk factors. 61
20299779 2007
49
Sticky platelet syndrome. 61
16981665 2006
50
[Disseminated coronary occlusions and massive pulmonary embolism in a 40-year-old woman]. 61
16555173 2006

Variations for Sticky Platelet Syndrome

Expression for Sticky Platelet Syndrome

Search GEO for disease gene expression data for Sticky Platelet Syndrome.

Pathways for Sticky Platelet Syndrome

GO Terms for Sticky Platelet Syndrome

Cellular components related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 SERPINE1 SERPINC1 ITGB3 GP6 GAS6
2 endoplasmic reticulum lumen GO:0005788 9.13 SERPINC1 GAS6 F5
3 platelet alpha granule lumen GO:0031093 8.8 SERPINE1 GAS6 F5

Biological processes related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.69 SERPINC1 GAS6 F5
2 cellular protein metabolic process GO:0044267 9.61 SERPINC1 GAS6 F5
3 leukocyte migration GO:0050900 9.58 ITGB3 GP6 GAS6
4 platelet aggregation GO:0070527 9.49 PEAR1 ITGB3
5 protein kinase B signaling GO:0043491 9.48 PEAR1 GAS6
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.46 SERPINE1 GAS6
7 apoptotic cell clearance GO:0043277 9.37 ITGB3 GAS6
8 hemostasis GO:0007599 9.33 SERPINC1 GP6 F5
9 cell-substrate adhesion GO:0031589 9.32 ITGB3 GAS6
10 enzyme linked receptor protein signaling pathway GO:0007167 9.26 GP6 GAS6
11 platelet degranulation GO:0002576 9.26 SERPINE1 ITGB3 GAS6 F5
12 blood coagulation GO:0007596 9.02 SERPINC1 ITGB3 GP6 GAS6 F5

Molecular functions related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 SERPINE1 SERPINC1 ITGB3

Sources for Sticky Platelet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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