MCID: STC016
MIFTS: 30

Sticky Platelet Syndrome

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Sticky Platelet Syndrome

MalaCards integrated aliases for Sticky Platelet Syndrome:

Name: Sticky Platelet Syndrome 53

Classifications:



Summaries for Sticky Platelet Syndrome

MalaCards based summary : Sticky Platelet Syndrome is related to thrombophilia and thrombosis. An important gene associated with Sticky Platelet Syndrome is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include spinal cord and placenta, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 76 Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was... more...

Related Diseases for Sticky Platelet Syndrome

Diseases related to Sticky Platelet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 30.1 F5 SERPINC1 SERPINE1
2 thrombosis 30.1 F5 GP6 SERPINC1 SERPINE1
3 protein s deficiency 29.9 F5 SERPINC1
4 thrombophilia due to thrombin defect 29.9 F5 SERPINC1 SERPINE1
5 pulmonary embolism 29.9 F5 SERPINC1 SERPINE1
6 patent foramen ovale 29.7 F5 SERPINC1
7 optic nerve disease 10.1
8 neuropathy 10.1
9 primary thrombocytopenia 10.1 GP6 ITGB3
10 inferior vena cava interruption 10.1 F5 SERPINE1
11 amaurosis fugax 10.1 F5 SERPINE1
12 sudden sensorineural hearing loss 10.1 F5 ITGB3
13 von willebrand disease, type 2 10.1 GP6 ITGB3
14 cryptogenic cirrhosis 10.1 F5 SERPINE1
15 catastrophic antiphospholipid syndrome 10.1 F5 SERPINE1
16 quebec platelet disorder 10.1 F5 SERPINE1
17 factor xiii deficiency 10.1 F5 SERPINE1
18 thrombocytopenic purpura, autoimmune 10.1 GP6 ITGB3
19 arteritic anterior ischemic optic neuropathy 10.1 F5 ITGB3
20 thrombasthenia 10.1 F5 ITGB3
21 infective endocarditis 10.0 ITGB3 SERPINE1
22 spinal cord infarction 10.0 F5 SERPINC1
23 prothrombin deficiency, congenital 10.0 F5 SERPINC1
24 sagittal sinus thrombosis 10.0 F5 SERPINC1
25 ischemia 10.0
26 antiphospholipid syndrome 10.0 F5 SERPINC1
27 retinal vascular occlusion 10.0 F5 SERPINC1
28 antithrombin iii deficiency 10.0 F5 SERPINC1
29 peripheral vertigo 10.0 F5 SERPINC1
30 central retinal vein occlusion 10.0 F5 SERPINC1
31 intracranial thrombosis 10.0 F5 SERPINC1
32 blood protein disease 10.0 F5 SERPINC1
33 fibrinolytic defect 10.0 SERPINC1 SERPINE1
34 factor xii deficiency 10.0 F5 SERPINC1
35 aspirin allergy 10.0 SERPINC1 SERPINE1
36 pulmonary artery disease 10.0 F5 SERPINC1
37 argentine hemorrhagic fever 10.0 SERPINC1 SERPINE1
38 dysfibrinogenemia 10.0 F5 SERPINC1
39 blue toe syndrome 10.0 SERPINC1 SERPINE1
40 subendocardial myocardial infarction 10.0 SERPINC1 SERPINE1
41 livedoid vasculitis 10.0 SERPINC1 SERPINE1
42 placental abruption 9.9 F5 SERPINC1
43 inherited blood coagulation disease 9.9 ITGB3 SERPINC1
44 hepatic vascular disease 9.9 SERPINC1 SERPINE1
45 protein c deficiency 9.9 F5 SERPINC1
46 hepatic veno-occlusive disease 9.9 SERPINC1 SERPINE1
47 factor x deficiency 9.9 F5 SERPINC1
48 epileptic encephalopathy, childhood-onset 9.9 SERPINC1 SERPINE1
49 nonarteritic anterior ischemic optic neuropathy 9.9 F5 SERPINC1
50 placenta disease 9.9 F5 SERPINC1

Graphical network of the top 20 diseases related to Sticky Platelet Syndrome:



Diseases related to Sticky Platelet Syndrome

Symptoms & Phenotypes for Sticky Platelet Syndrome

MGI Mouse Phenotypes related to Sticky Platelet Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 GAS6 GP6 ITGB3 PEAR1 SERPINC1 SERPINE1
2 cardiovascular system MP:0005385 9.72 F5 GAS6 ITGB3 SERPINC1 SERPINE1
3 homeostasis/metabolism MP:0005376 9.7 F5 GAS6 GP6 ITGB3 PEAR1 SERPINC1
4 liver/biliary system MP:0005370 9.26 F5 ITGB3 SERPINC1 SERPINE1
5 renal/urinary system MP:0005367 8.92 GAS6 ITGB3 SERPINC1 SERPINE1

Drugs & Therapeutics for Sticky Platelet Syndrome

Search Clinical Trials , NIH Clinical Center for Sticky Platelet Syndrome

Genetic Tests for Sticky Platelet Syndrome

Anatomical Context for Sticky Platelet Syndrome

MalaCards organs/tissues related to Sticky Platelet Syndrome:

41
Spinal Cord, Placenta

Publications for Sticky Platelet Syndrome

Articles related to Sticky Platelet Syndrome:

(show all 38)
# Title Authors Year
1
Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss. ( 29850310 )
2018
2
Progress in the Understanding of Sticky Platelet Syndrome. ( 27299808 )
2017
3
Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in People with Sticky Platelet Syndrome. ( 28179211 )
2017
4
GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. ( 28041267 )
2016
5
Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. ( 26567442 )
2016
6
Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. ( 26308704 )
2015
7
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. ( 25703520 )
2015
8
The sticky platelet syndrome during carotid endarterectomy. ( 26032011 )
2015
9
Comment on Sticky platelet syndrome. ( 24500576 )
2014
10
Sticky platelet syndrome: history and future perspectives. ( 24911675 )
2014
11
Response to "Comment on Sticky platelet syndrome". ( 24497123 )
2014
12
Nine kindreds of familial sticky platelet syndrome phenotype. ( 22431856 )
2013
13
The sticky platelet syndrome. ( 23433500 )
2013
14
Primary Thrombophilia in Mexico X: A Prospective Study of the Treatment of the Sticky Platelet Syndrome. ( 24057395 )
2013
15
Sticky platelet syndrome in patients with uninduced venous thrombosis. ( 24385753 )
2013
16
Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. ( 22751911 )
2013
17
Sticky platelet syndrome. ( 23934738 )
2013
18
Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. ( 22821001 )
2012
19
The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. ( 23168074 )
2012
20
Are the platelets activated in sticky platelet syndrome? ( 21450332 )
2011
21
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. ( 21716756 )
2011
22
Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. ( 21252804 )
2011
23
Is Gas6 protein associated with sticky platelet syndrome? ( 19696043 )
2010
24
Sticky platelet syndrome as a possible cause for free flap failure--a case report. ( 20238381 )
2010
25
Sticky platelet syndrome: an unusual presentation of arterial ischemia. ( 20363102 )
2010
26
Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. ( 18662911 )
2009
27
Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. ( 18995884 )
2009
28
Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. ( 18093268 )
2008
29
Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. ( 17532753 )
2007
30
Sticky platelet syndrome and anterior ischaemic optic neuropathy. ( 17997790 )
2007
31
The glycoprotein IIIa PL(A1/A2) polymorphism--a defect responsible for the sticky platelet syndrome? ( 16444447 )
2006
32
Sticky platelet syndrome. ( 16981665 )
2006
33
Sticky platelet syndrome and thrombocythemia. ( 12627663 )
2003
34
Primary thrombophilia in Mexico III: A prospective study of the sticky platelet syndrome. ( 12361206 )
2002
35
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. ( 9973658 )
1999
36
Sticky platelet syndrome. ( 10548069 )
1999
37
Sticky Platelet Syndrome: a Cause of Neurovascular Thrombosis and Thrombo-embolism. ( 20678352 )
1997
38
"Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis? ( 2465231 )
1988

Variations for Sticky Platelet Syndrome

Expression for Sticky Platelet Syndrome

Search GEO for disease gene expression data for Sticky Platelet Syndrome.

Pathways for Sticky Platelet Syndrome

GO Terms for Sticky Platelet Syndrome

Cellular components related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 GAS6 GP6 ITGB3 SERPINC1 SERPINE1
2 endoplasmic reticulum lumen GO:0005788 9.13 F5 GAS6 SERPINC1
3 platelet alpha granule lumen GO:0031093 8.8 F5 GAS6 SERPINE1

Biological processes related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.7 F5 GAS6 SERPINC1
2 cellular protein metabolic process GO:0044267 9.65 F5 GAS6 SERPINC1
3 leukocyte migration GO:0050900 9.63 GAS6 GP6 ITGB3
4 viral entry into host cell GO:0046718 9.54 GAS6 ITGB3
5 platelet activation GO:0030168 9.54 GAS6 GP6 ITGB3
6 protein kinase B signaling GO:0043491 9.51 GAS6 PEAR1
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 GAS6 SERPINE1
8 apoptotic cell clearance GO:0043277 9.43 GAS6 ITGB3
9 hemostasis GO:0007599 9.43 F5 GP6 SERPINC1
10 cell-substrate adhesion GO:0031589 9.4 GAS6 ITGB3
11 platelet aggregation GO:0070527 9.33 GAS6 ITGB3 PEAR1
12 enzyme linked receptor protein signaling pathway GO:0007167 9.32 GAS6 GP6
13 platelet degranulation GO:0002576 9.26 F5 GAS6 ITGB3 SERPINE1
14 blood coagulation GO:0007596 9.02 F5 GAS6 GP6 ITGB3 SERPINC1

Molecular functions related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 ITGB3 SERPINC1 SERPINE1

Sources for Sticky Platelet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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