MCID: STC016
MIFTS: 28

Sticky Platelet Syndrome

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Sticky Platelet Syndrome

MalaCards integrated aliases for Sticky Platelet Syndrome:

Name: Sticky Platelet Syndrome 54

Classifications:



Summaries for Sticky Platelet Syndrome

MalaCards based summary : Sticky Platelet Syndrome is related to thrombophilia and protein s deficiency. An important gene associated with Sticky Platelet Syndrome is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was... more...

Related Diseases for Sticky Platelet Syndrome

Diseases related to Sticky Platelet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 29.9 F5 SERPINC1 SERPINE1
2 protein s deficiency 29.8 F5 SERPINC1
3 thrombosis 29.8 F5 GP6 SERPINC1 SERPINE1
4 thrombophilia due to thrombin defect 29.7 F5 SERPINC1 SERPINE1
5 pulmonary embolism 29.7 F5 SERPINC1 SERPINE1
6 patent foramen ovale 29.5 F5 SERPINC1
7 primary thrombocytopenia 10.2 GP6 ITGB3
8 von willebrand disease, type 2 10.2 GP6 ITGB3
9 thrombocytopenic purpura, autoimmune 10.1 GP6 ITGB3
10 sudden sensorineural hearing loss 10.1 F5 ITGB3
11 optic nerve disease 10.1
12 neuropathy 10.1
13 inferior vena cava interruption 10.1 F5 SERPINE1
14 amaurosis fugax 10.1 F5 SERPINE1
15 cryptogenic cirrhosis 10.1 F5 SERPINE1
16 catastrophic antiphospholipid syndrome 10.1 F5 SERPINE1
17 arteritic anterior ischemic optic neuropathy 10.1 F5 ITGB3
18 quebec platelet disorder 10.1 F5 SERPINE1
19 factor xiii deficiency 10.1 F5 SERPINE1
20 thrombasthenia 10.1 F5 ITGB3
21 infective endocarditis 10.1 ITGB3 SERPINE1
22 ischemia 10.0
23 hemorrhagic fever 10.0 ITGB3 SERPINC1
24 inherited blood coagulation disease 9.9 ITGB3 SERPINC1
25 fibrinolytic defect 9.9 SERPINC1 SERPINE1
26 spinal cord infarction 9.9 F5 SERPINC1
27 aspirin allergy 9.9 SERPINC1 SERPINE1
28 argentine hemorrhagic fever 9.9 SERPINC1 SERPINE1
29 prothrombin deficiency, congenital 9.9 F5 SERPINC1
30 sagittal sinus thrombosis 9.9 F5 SERPINC1
31 blue toe syndrome 9.9 SERPINC1 SERPINE1
32 antiphospholipid syndrome 9.9 F5 SERPINC1
33 subendocardial myocardial infarction 9.9 SERPINC1 SERPINE1
34 livedoid vasculitis 9.9 SERPINC1 SERPINE1
35 retinal vascular occlusion 9.9 F5 SERPINC1
36 antithrombin iii deficiency 9.9 F5 SERPINC1
37 peripheral vertigo 9.9 F5 SERPINC1
38 central retinal vein occlusion 9.9 F5 SERPINC1
39 intracranial thrombosis 9.9 F5 SERPINC1
40 blood protein disease 9.9 F5 SERPINC1
41 factor xii deficiency 9.9 F5 SERPINC1
42 hepatic vascular disease 9.9 SERPINC1 SERPINE1
43 pulmonary artery disease 9.9 F5 SERPINC1
44 dysfibrinogenemia 9.9 F5 SERPINC1
45 purpura 9.9 ITGB3 SERPINC1
46 hepatic veno-occlusive disease 9.9 SERPINC1 SERPINE1
47 placental abruption 9.9 F5 SERPINC1
48 epileptic encephalopathy, childhood-onset 9.9 SERPINC1 SERPINE1
49 protein c deficiency 9.9 F5 SERPINC1
50 intermittent claudication 9.8 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Sticky Platelet Syndrome:



Diseases related to Sticky Platelet Syndrome

Symptoms & Phenotypes for Sticky Platelet Syndrome

MGI Mouse Phenotypes related to Sticky Platelet Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 GAS6 GP6 ITGB3 PEAR1 SERPINC1 SERPINE1
2 cardiovascular system MP:0005385 9.72 F5 GAS6 ITGB3 SERPINC1 SERPINE1
3 homeostasis/metabolism MP:0005376 9.7 F5 GAS6 GP6 ITGB3 PEAR1 SERPINC1
4 liver/biliary system MP:0005370 9.26 F5 ITGB3 SERPINC1 SERPINE1
5 renal/urinary system MP:0005367 8.92 GAS6 ITGB3 SERPINC1 SERPINE1

Drugs & Therapeutics for Sticky Platelet Syndrome

Search Clinical Trials , NIH Clinical Center for Sticky Platelet Syndrome

Genetic Tests for Sticky Platelet Syndrome

Anatomical Context for Sticky Platelet Syndrome

Publications for Sticky Platelet Syndrome

Articles related to Sticky Platelet Syndrome:

(show all 40)
# Title Authors Year
1
Commentary: Controversies in Thrombosis and Hemostasis Part 2-Does Sticky Platelet Syndrome Exist? ( 30630203 )
2019
2
Sticky Platelet Syndrome: 35 Years of Growing Evidence. ( 30630207 )
2019
3
Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss. ( 29850310 )
2018
4
Progress in the Understanding of Sticky Platelet Syndrome. ( 27299808 )
2017
5
Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in People with Sticky Platelet Syndrome. ( 28179211 )
2017
6
GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. ( 28041267 )
2016
7
Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. ( 26567442 )
2016
8
Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. ( 26308704 )
2015
9
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. ( 25703520 )
2015
10
The sticky platelet syndrome during carotid endarterectomy. ( 26032011 )
2015
11
Comment on Sticky platelet syndrome. ( 24500576 )
2014
12
Sticky platelet syndrome: history and future perspectives. ( 24911675 )
2014
13
Response to "Comment on Sticky platelet syndrome". ( 24497123 )
2014
14
Nine kindreds of familial sticky platelet syndrome phenotype. ( 22431856 )
2013
15
The sticky platelet syndrome. ( 23433500 )
2013
16
Primary Thrombophilia in Mexico X: A Prospective Study of the Treatment of the Sticky Platelet Syndrome. ( 24057395 )
2013
17
Sticky platelet syndrome in patients with uninduced venous thrombosis. ( 24385753 )
2013
18
Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. ( 22751911 )
2013
19
Sticky platelet syndrome. ( 23934738 )
2013
20
Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. ( 22821001 )
2012
21
The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. ( 23168074 )
2012
22
Are the platelets activated in sticky platelet syndrome? ( 21450332 )
2011
23
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. ( 21716756 )
2011
24
Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. ( 21252804 )
2011
25
Is Gas6 protein associated with sticky platelet syndrome? ( 19696043 )
2010
26
Sticky platelet syndrome as a possible cause for free flap failure--a case report. ( 20238381 )
2010
27
Sticky platelet syndrome: an unusual presentation of arterial ischemia. ( 20363102 )
2010
28
Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. ( 18662911 )
2009
29
Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. ( 18995884 )
2009
30
Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. ( 18093268 )
2008
31
Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. ( 17532753 )
2007
32
Sticky platelet syndrome and anterior ischaemic optic neuropathy. ( 17997790 )
2007
33
The glycoprotein IIIa PL(A1/A2) polymorphism--a defect responsible for the sticky platelet syndrome? ( 16444447 )
2006
34
Sticky platelet syndrome. ( 16981665 )
2006
35
Sticky platelet syndrome and thrombocythemia. ( 12627663 )
2003
36
Primary thrombophilia in Mexico III: A prospective study of the sticky platelet syndrome. ( 12361206 )
2002
37
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. ( 9973658 )
1999
38
Sticky platelet syndrome. ( 10548069 )
1999
39
Sticky Platelet Syndrome: a Cause of Neurovascular Thrombosis and Thrombo-embolism. ( 20678352 )
1997
40
"Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis? ( 2465231 )
1988

Variations for Sticky Platelet Syndrome

Expression for Sticky Platelet Syndrome

Search GEO for disease gene expression data for Sticky Platelet Syndrome.

Pathways for Sticky Platelet Syndrome

GO Terms for Sticky Platelet Syndrome

Cellular components related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 GAS6 GP6 ITGB3 SERPINC1 SERPINE1
2 endoplasmic reticulum lumen GO:0005788 9.13 F5 GAS6 SERPINC1
3 platelet alpha granule lumen GO:0031093 8.8 F5 GAS6 SERPINE1

Biological processes related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.7 F5 GAS6 SERPINC1
2 cellular protein metabolic process GO:0044267 9.65 F5 GAS6 SERPINC1
3 leukocyte migration GO:0050900 9.63 GAS6 GP6 ITGB3
4 viral entry into host cell GO:0046718 9.54 GAS6 ITGB3
5 platelet activation GO:0030168 9.54 GAS6 GP6 ITGB3
6 protein kinase B signaling GO:0043491 9.51 GAS6 PEAR1
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 GAS6 SERPINE1
8 apoptotic cell clearance GO:0043277 9.43 GAS6 ITGB3
9 hemostasis GO:0007599 9.43 F5 GP6 SERPINC1
10 cell-substrate adhesion GO:0031589 9.4 GAS6 ITGB3
11 platelet aggregation GO:0070527 9.33 GAS6 ITGB3 PEAR1
12 enzyme linked receptor protein signaling pathway GO:0007167 9.32 GAS6 GP6
13 platelet degranulation GO:0002576 9.26 F5 GAS6 ITGB3 SERPINE1
14 blood coagulation GO:0007596 9.02 F5 GAS6 GP6 ITGB3 SERPINC1

Molecular functions related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 ITGB3 SERPINC1 SERPINE1

Sources for Sticky Platelet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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