MCID: STC016
MIFTS: 29

Sticky Platelet Syndrome

Categories: Blood diseases, Rare diseases

Aliases & Classifications for Sticky Platelet Syndrome

MalaCards integrated aliases for Sticky Platelet Syndrome:

Name: Sticky Platelet Syndrome 54

Classifications:



Summaries for Sticky Platelet Syndrome

MalaCards based summary : Sticky Platelet Syndrome is related to protein s deficiency and thrombophilia. An important gene associated with Sticky Platelet Syndrome is GP6 (Glycoprotein VI Platelet), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include spinal cord and placenta, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 77 Sticky platelet syndrome is a term used by some to describe a disorder of platelet function. It was... more...

Related Diseases for Sticky Platelet Syndrome

Diseases related to Sticky Platelet Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 protein s deficiency 30.0 F5 SERPINC1
2 thrombophilia 29.9 F5 SERPINC1 SERPINE1
3 livedoid vasculitis 29.8 SERPINC1 SERPINE1
4 thrombosis 29.7 F5 GP6 SERPINC1 SERPINE1
5 patent foramen ovale 29.6 F5 SERPINC1
6 thrombophilia due to thrombin defect 29.6 F5 SERPINC1 SERPINE1
7 pulmonary embolism 29.6 F5 SERPINC1 SERPINE1
8 thrombophilia due to activated protein c resistance 29.3 F5 SERPINC1 SERPINE1
9 primary thrombocytopenia 10.2 GP6 ITGB3
10 von willebrand disease, type 2 10.2 GP6 ITGB3
11 thrombocytopenic purpura, autoimmune 10.2 GP6 ITGB3
12 sudden sensorineural hearing loss 10.1 F5 ITGB3
13 optic nerve disease 10.1
14 neuropathy 10.1
15 arteritic anterior ischemic optic neuropathy 10.1 F5 ITGB3
16 thrombasthenia 10.1 F5 ITGB3
17 inherited blood coagulation disease 10.1 ITGB3 SERPINC1
18 spinal cord infarction 10.1 F5 SERPINC1
19 prothrombin deficiency, congenital 10.0 F5 SERPINC1
20 sagittal sinus thrombosis 10.0 F5 SERPINC1
21 antiphospholipid syndrome 10.0 F5 SERPINC1
22 retinal vascular occlusion 10.0 F5 SERPINC1
23 antithrombin iii deficiency 10.0 F5 SERPINC1
24 peripheral vertigo 10.0 F5 SERPINC1
25 central retinal vein occlusion 10.0 F5 SERPINC1
26 intracranial thrombosis 10.0 F5 SERPINC1
27 blood protein disease 10.0 F5 SERPINC1
28 factor xii deficiency 10.0 F5 SERPINC1
29 pulmonary artery disease 10.0 F5 SERPINC1
30 dysfibrinogenemia 10.0 F5 SERPINC1
31 purpura 10.0 ITGB3 SERPINC1
32 placental abruption 10.0 F5 SERPINC1
33 stiff-person syndrome 10.0
34 ischemia 10.0
35 protein c deficiency 10.0 F5 SERPINC1
36 factor x deficiency 10.0 F5 SERPINC1
37 nonarteritic anterior ischemic optic neuropathy 9.9 F5 SERPINC1
38 inferior vena cava interruption 9.9 F5 SERPINE1
39 amaurosis fugax 9.9 F5 SERPINE1
40 placenta disease 9.9 F5 SERPINC1
41 cryptogenic cirrhosis 9.9 F5 SERPINE1
42 catastrophic antiphospholipid syndrome 9.9 F5 SERPINE1
43 quebec platelet disorder 9.9 F5 SERPINE1
44 severe pre-eclampsia 9.9 F5 SERPINC1
45 factor xiii deficiency 9.9 F5 SERPINE1
46 budd-chiari syndrome 9.9 F5 SERPINC1
47 infective endocarditis 9.9 ITGB3 SERPINE1
48 blood platelet disease 9.9 ITGB3 SERPINC1
49 homocysteinemia 9.9 F5 SERPINC1
50 fibrinolytic defect 9.9 SERPINC1 SERPINE1

Graphical network of the top 20 diseases related to Sticky Platelet Syndrome:



Diseases related to Sticky Platelet Syndrome

Symptoms & Phenotypes for Sticky Platelet Syndrome

MGI Mouse Phenotypes related to Sticky Platelet Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 GAS6 GP6 ITGB3 PEAR1 SERPINC1 SERPINE1
2 cardiovascular system MP:0005385 9.72 F5 GAS6 ITGB3 SERPINC1 SERPINE1
3 homeostasis/metabolism MP:0005376 9.7 F5 GAS6 GP6 ITGB3 PEAR1 SERPINC1
4 liver/biliary system MP:0005370 9.26 F5 ITGB3 SERPINC1 SERPINE1
5 renal/urinary system MP:0005367 8.92 GAS6 ITGB3 SERPINC1 SERPINE1

Drugs & Therapeutics for Sticky Platelet Syndrome

Search Clinical Trials , NIH Clinical Center for Sticky Platelet Syndrome

Genetic Tests for Sticky Platelet Syndrome

Anatomical Context for Sticky Platelet Syndrome

MalaCards organs/tissues related to Sticky Platelet Syndrome:

42
Spinal Cord, Placenta

Publications for Sticky Platelet Syndrome

Articles related to Sticky Platelet Syndrome:

(show all 42)
# Title Authors Year
1
Commentary: Controversies in Thrombosis and Hemostasis Part 2-Does Sticky Platelet Syndrome Exist? ( 30630203 )
2019
2
Sticky Platelet Syndrome: 35 Years of Growing Evidence. ( 30630207 )
2019
3
Primary Thrombophilia in Mexico XIII: Localization of the Thrombotic Events in Mexican Mestizos With the Sticky Platelet Syndrome. ( 30968703 )
2019
4
Primary Thrombophilia XIV: Worldwide Identification of Sticky Platelet Syndrome. ( 31041794 )
2019
5
GP6 Haplotype of Missense Variants is Associated with Sticky Platelet Syndrome Manifested by Fetal Loss. ( 28041267 )
2018
6
Sticky Platelet Syndrome: An Unrecognized Cause of Acute Thrombosis and Graft Loss. ( 29850310 )
2018
7
Progress in the Understanding of Sticky Platelet Syndrome. ( 27299808 )
2017
8
Primary Thrombophilia in Mexico XII: Miscarriages Are More Frequent in People with Sticky Platelet Syndrome. ( 28179211 )
2017
9
Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. ( 26567442 )
2016
10
Primary thrombophilia in México X: a prospective study of the treatment of the sticky platelet syndrome. ( 24057395 )
2015
11
Different models of inheritance in selected genes in patients with sticky platelet syndrome and fetal loss. ( 25703520 )
2015
12
The sticky platelet syndrome during carotid endarterectomy. ( 26032011 )
2015
13
Genetic variations of the GP6 regulatory region in patients with sticky platelet syndrome and miscarriage. ( 26308704 )
2015
14
Response to "Comment on Sticky platelet syndrome". ( 24497123 )
2014
15
Comment on Sticky platelet syndrome. ( 24500576 )
2014
16
Sticky platelet syndrome: history and future perspectives. ( 24911675 )
2014
17
Nine kindreds of familial sticky platelet syndrome phenotype. ( 22431856 )
2013
18
Primary thrombophilia in Mexico IX: the glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome phenotype. ( 22751911 )
2013
19
The sticky platelet syndrome. ( 23433500 )
2013
20
Sticky platelet syndrome. ( 23934738 )
2013
21
Sticky platelet syndrome in patients with uninduced venous thrombosis. ( 24385753 )
2013
22
Variability of GP6 gene in patients with sticky platelet syndrome and deep venous thrombosis and/or pulmonary embolism. ( 22821001 )
2012
23
The prevalence of the platelet glycoprotein VI polymorphisms in patients with sticky platelet syndrome and ischemic stroke. ( 23168074 )
2012
24
Recurrent strokes under anticoagulation therapy: Sticky platelet syndrome combined with a patent foramen ovale. ( 21716756 )
2011
25
Extensive thrombosis and first-trimester pregnancy loss caused by sticky platelet syndrome. ( 21252804 )
2011
26
Are the platelets activated in sticky platelet syndrome? ( 21450332 )
2011
27
Is Gas6 protein associated with sticky platelet syndrome? ( 19696043 )
2010
28
Sticky platelet syndrome as a possible cause for free flap failure--a case report. ( 20238381 )
2010
29
Sticky platelet syndrome: an unusual presentation of arterial ischemia. ( 20363102 )
2010
30
Bilateral simultaneous anterior ischaemic optic neuropathy associated with Sticky Platelet Syndrome. ( 18662911 )
2009
31
Sticky platelet syndrome type II presenting with arterial microemboli in the fingers. ( 18995884 )
2009
32
Sticky platelet syndrome: a manageable risk factor for posttransplant thromboembolic events. ( 18093268 )
2008
33
Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients. ( 17532753 )
2007
34
Sticky platelet syndrome and anterior ischaemic optic neuropathy. ( 17997790 )
2007
35
The glycoprotein IIIa PL(A1/A2) polymorphism--a defect responsible for the sticky platelet syndrome? ( 16444447 )
2006
36
Sticky platelet syndrome. ( 16981665 )
2006
37
Sticky platelet syndrome and thrombocythemia. ( 12627663 )
2003
38
Primary thrombophilia in Mexico III: A prospective study of the sticky platelet syndrome. ( 12361206 )
2002
39
Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes. ( 9973658 )
1999
40
Sticky platelet syndrome. ( 10548069 )
1999
41
Sticky Platelet Syndrome: a Cause of Neurovascular Thrombosis and Thrombo-embolism. ( 20678352 )
1997
42
"Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis? ( 2465231 )
1988

Variations for Sticky Platelet Syndrome

Expression for Sticky Platelet Syndrome

Search GEO for disease gene expression data for Sticky Platelet Syndrome.

Pathways for Sticky Platelet Syndrome

GO Terms for Sticky Platelet Syndrome

Cellular components related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.55 GAS6 GP6 ITGB3 SERPINC1 SERPINE1
2 endoplasmic reticulum lumen GO:0005788 9.13 F5 GAS6 SERPINC1
3 platelet alpha granule lumen GO:0031093 8.8 F5 GAS6 SERPINE1

Biological processes related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.7 F5 GAS6 SERPINC1
2 cellular protein metabolic process GO:0044267 9.65 F5 GAS6 SERPINC1
3 leukocyte migration GO:0050900 9.63 GAS6 GP6 ITGB3
4 viral entry into host cell GO:0046718 9.54 GAS6 ITGB3
5 platelet activation GO:0030168 9.54 GAS6 GP6 ITGB3
6 protein kinase B signaling GO:0043491 9.51 GAS6 PEAR1
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 GAS6 SERPINE1
8 apoptotic cell clearance GO:0043277 9.43 GAS6 ITGB3
9 hemostasis GO:0007599 9.43 F5 GP6 SERPINC1
10 cell-substrate adhesion GO:0031589 9.4 GAS6 ITGB3
11 platelet aggregation GO:0070527 9.33 GAS6 ITGB3 PEAR1
12 enzyme linked receptor protein signaling pathway GO:0007167 9.32 GAS6 GP6
13 platelet degranulation GO:0002576 9.26 F5 GAS6 ITGB3 SERPINE1
14 blood coagulation GO:0007596 9.02 F5 GAS6 GP6 ITGB3 SERPINC1

Molecular functions related to Sticky Platelet Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 ITGB3 SERPINC1 SERPINE1

Sources for Sticky Platelet Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....