Aliases & Classifications for Storm Syndrome

MalaCards integrated aliases for Storm Syndrome:

Name: Storm Syndrome 57 20 70
Pleiotropic, Autosomal Dominant Disorder Affecting Connective Tissue 20

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
storm syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 185069
MedGen 41 C1861452
UMLS 70 C1861452

Summaries for Storm Syndrome

MalaCards based summary : Storm Syndrome, also known as pleiotropic, autosomal dominant disorder affecting connective tissue, is related to cytokine deficiency and covid-19. An important gene associated with Storm Syndrome is IL6 (Interleukin 6). The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and liver, and related phenotypes are mitral valve calcification and fat malabsorption

More information from OMIM: 185069

Related Diseases for Storm Syndrome

Graphical network of the top 20 diseases related to Storm Syndrome:



Diseases related to Storm Syndrome

Symptoms & Phenotypes for Storm Syndrome

Human phenotypes related to Storm Syndrome:

31 (show all 10)
# Description HPO Frequency HPO Source Accession
1 mitral valve calcification 31 HP:0004382
2 fat malabsorption 31 HP:0002630
3 aortic valve calcification 31 HP:0004380
4 mitral stenosis 31 HP:0001718
5 aortic valve stenosis 31 HP:0001650
6 excessive wrinkling of palmar skin 31 HP:0007605
7 polyarticular arthropathy 31 HP:0005195
8 sparse and thin eyebrow 31 HP:0000535
9 myxomatous mitral valve degeneration 31 HP:0004764
10 early progressive calcific cardiac valvular disease 31 HP:0006694

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Cardiac:
mitral valve prolapse
myxomatous mitral valve degeneration
early progressive calcific cardiac valvular disease
calcific mitral stenosis
calcific aortic stenosis

Joints:
polyarticular arthropathy

Eyes:
no cataracts

Skin:
prematurely aged appearance
excessive wrinkling of palmar skin
taut skin over hands and face
no scleroderma-type changes

Hair:
loss of eyebrows and eyelashes
thinning and graying of scalp hair in adolescence

G I:
intestinal fat malabsorption

Clinical features from OMIM®:

185069 (Updated 05-Apr-2021)

Drugs & Therapeutics for Storm Syndrome

Drugs for Storm Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 3
2 Interleukin 1 Receptor Antagonist Protein Phase 3
3
Prazosin Approved Phase 2 19216-56-9 4893
4 Adrenergic alpha-1 Receptor Antagonists Phase 2
5 Adrenergic alpha-Antagonists Phase 2
6 Adrenergic Antagonists Phase 2
7 Neurotransmitter Agents Phase 2
8 Adrenergic Agents Phase 2
9 Antihypertensive Agents Phase 2
10 Pharmaceutical Solutions Phase 2
11
Infliximab Approved 170277-31-3
12 Dermatologic Agents
13 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Trial of the Use of Anakinra in Cytokine Storm Syndrome Secondary to Covid-19. A Phase 2/3, Randomized, Open-label, Parallel Group, 2-arm, Multicenter Study Investigating the Efficacy and Safety of Intravenous Administrations of Anakinra, an Interleukin-1(IL-1) Receptor Antagonist, Added to Standard of Care, Versus Standard of Care, in Reducing Hyper-inflammation and Respiratory Distress in Patients With SARS- CoV-2 Infection Recruiting NCT04443881 Phase 2, Phase 3 Anakinra 149 MG/ML Prefilled Syringe [Kineret]
2 Early Treatment of Cytokine Storm Syndrome in Covid-19 Recruiting NCT04362111 Phase 3 Anakinra;Normal saline
3 Alpha-1 Adrenergic Receptor Antagonism to Prevent COVID-19 Cytokine Storm Syndrome and Acute Respiratory Distress Syndrome: A Randomized Study Comparing the Efficacy of Prazosin vs. Standard of Care for SARS-CoV-2 Infection Recruiting NCT04365257 Phase 2 Prazosin
4 Anakinra in Adults With Severe COVID-19 and Features of Cytokine Storm Syndrome: A Randomized, Double-blind, Placebo-controlled Trial Not yet recruiting NCT04603742 Phase 2 Anakinra;0.9% Saline
5 Comparison of Tocilizumab Versus Tocilizumab/Infliximab in Patients With COVID-19-associated Cytokine Storm Syndrome Recruiting NCT04734678 Tocilizumab;Infliximab
6 Randomized Open Controlled Clinical Trial to Evaluate the Effectiveness of a Eucaloric Ketogenic Nutrition in Comparison With a Standard Nutrition in Covid-19 Disease in Reducing Cytokine Storm Syndrome and ARDS Recruiting NCT04492228

Search NIH Clinical Center for Storm Syndrome

Genetic Tests for Storm Syndrome

Anatomical Context for Storm Syndrome

MalaCards organs/tissues related to Storm Syndrome:

40
Lung, Heart, Liver, Myeloid, Monocytes, T Cells, Neutrophil

Publications for Storm Syndrome

Articles related to Storm Syndrome:

(show top 50) (show all 186)
# Title Authors PMID Year
1
COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue. 61
33522893 2021
2
Machine learning-based cytokine microarray digital immunoassay analysis. 61
33647790 2021
3
ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. 61
33723527 2021
4
Worsening of heart failure by coronavirus disease 2019 is associated with high mortality. 61
33498096 2021
5
COVID-19 and cytokine storm syndrome: are there lessons from macrophage activation syndrome? 61
33684592 2021
6
COVID-19: disease pathways and gene expression changes predict methylprednisolone can improve outcome in severe cases. 61
33693506 2021
7
COVID-19-induced hyperinflammation, immunosuppression, recovery and survival: how causal inference may help draw robust conclusions. 61
33790049 2021
8
Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs. 61
33745077 2021
9
Prognostic Values of Serum Ferritin and D-Dimer Trajectory in Patients with COVID-19. 61
33807920 2021
10
Treatment With Tocilizumab for Patients With COVID-19 Infections: A Case-Series Study. 61
33180360 2021
11
Clinical Characteristics of Paediatric Hyperinflammatory Syndrome in the Era of Corona Virus Disease 2019 (COVID-19). 61
33716413 2021
12
Response to: 'Correspondence on 'Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study'' by Charles. 61
33658235 2021
13
Rapid Implementation of a Multidisciplinary COVID-19 Cytokine Storm Syndrome Task Force. 61
33547873 2021
14
Non-canonical autophagy functions of ATG16L1 in epithelial cells limit lethal infection by influenza A virus. 61
33586810 2021
15
Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2. 61
32988772 2021
16
Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019. 61
33445833 2021
17
Cytokine storm syndrome in coronavirus disease 2019: A narrative review. 61
32696489 2021
18
Response to: 'Correspondence on 'Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study'' by De Santis et al. 61
33593737 2021
19
Infliximab and Intravenous Gammaglobulin in Hospitalized Severe COVID-19 Patients in Intensive Care Unit. 61
33636983 2021
20
COVID-19: Immunology, Immunopathogenesis and Potential Therapies. 61
33641587 2021
21
COVID-19 cytokine storm syndrome: a threshold concept. 61
33655230 2021
22
Comparison of baseline laboratory findings of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis and multisystem inflammatory syndrome in children. 61
33550678 2021
23
Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients. 61
33348065 2021
24
CNS implications of COVID-19: a comprehensive review. 61
33550782 2021
25
Response to: 'Correspondence on 'Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study'' by Charles. 61
33589439 2021
26
SARS-CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges. 61
33557330 2021
27
Correspondence on 'Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study'. 61
33593740 2021
28
Correspondence on 'Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study'. 61
33589440 2021
29
Ruxolitinib as adjunctive therapy for secondary hemophagocytic lymphohistiocytosis: A case series. 61
33523540 2021
30
Association of α1-Blocker Receipt With 30-Day Mortality and Risk of Intensive Care Unit Admission Among Adults Hospitalized With Influenza or Pneumonia in Denmark. 61
33566109 2021
31
The Impact of SARS-CoV-2 Infection on the Development of Neurodegeneration in Multiple Sclerosis. 61
33670394 2021
32
COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied? 61
33550983 2021
33
Response to Treatment with an Anti-Interleukin-6 Receptor Antibody (Tocilizumab) in a Patient with Hemophagocytic Syndrome Secondary to Immune Checkpoint Inhibitors. 61
33628551 2021
34
Nucleocapsid and Spike Proteins of the Coronavirus SARS-CoV-2 Induce IL6 in Monocytes and Macrophages-Potential Implications for Cytokine Storm Syndrome. 61
33467724 2021
35
Infusion of HLA-matched and static magnetic field-exposed allogenic lymphocytes treating lymphocytopenia and cytokine storm syndrome: A treatment proposal for COVID-19 patients. 61
33073612 2021
36
Diagnosis of Adult Onset Still's Disease in a Patient Who has recovered from Coronavirus-19. 61
33679145 2021
37
Relationship between disease severity and serum IL-6 levels in COVID-19 anosmia. 61
33152573 2021
38
Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy. 61
33414226 2021
39
Hemophagocytic lymphohistiocytosis: a review inspired by the COVID-19 pandemic. 61
32588191 2021
40
Ultraefficiently Calming Cytokine Storm Using Ti3C2T x MXene. 61
33786372 2021
41
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes. 61
33558024 2021
42
Weathering the COVID-19 storm: Lessons from hematologic cytokine syndromes. 61
32425294 2021
43
Ischaemic stroke as an initial presentation in patients with COVID-19: evaluation of a case series in an emergency in Brazil. 61
33455541 2021
44
Therapeutic agents against COVID-19 with clinical evidence. 61
33459226 2021
45
SARS-CoV-2 morbidity and mortality in racial/ethnic minority populations: A window into the stress related inflammatory basis of health disparities? 61
33052326 2020
46
Distinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine storm. 61
33187979 2020
47
Acute pancreatitis in a COVID-19 patient: An unusual presentation. 61
33363941 2020
48
Cytokine storms caused by novel coronavirus 2019 and treatment for cardiac injury. 61
33336773 2020
49
Treatment of cytokine storm syndrome with IL-1 receptor antagonist anakinra in a patient with ARDS caused by COVID-19 infection: A case report. 61
33363865 2020
50
A Cytokine Circus with a Viral Ringleader: SARS-CoV-2-Associated Cytokine Storm Syndromes. 61
33051104 2020

Variations for Storm Syndrome

Expression for Storm Syndrome

Search GEO for disease gene expression data for Storm Syndrome.

Pathways for Storm Syndrome

GO Terms for Storm Syndrome

Sources for Storm Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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