Aliases & Classifications for Strabismus

MalaCards integrated aliases for Strabismus:

Name: Strabismus 57 12 76 29 55 6 15 73
Strabismus, Susceptibility to, 1 57 13
Strabismus, Susceptibility to 57
Susceptibility to Strabismus 29
Strabismus 1 57

Characteristics:

OMIM:

57
Inheritance:
familial, but no simple mendelian inheritance established


Classifications:



External Ids:

OMIM 57 185100
Disease Ontology 12 DOID:540
ICD9CM 35 378.7
MedGen 42 C1861449
SNOMED-CT via HPO 69 128602000 22066006

Summaries for Strabismus

OMIM : 57 Strabismus, a misalignment of the eyes also referred to as 'squint,' is one of the most common ocular disorders in humans, affecting 1 to 4% of the population. It is frequently associated with amblyopia (uniocular visual neglect) (Parikh et al., 2003). Strabismus is also a feature of several syndromic syndromes, including congenital fibrosis of extraocular muscles (see, e.g., FEOM1; 135700), Duane retraction syndrome (126800), and chronic progressive external ophthalmoplegia (530000). (185100)

MalaCards based summary : Strabismus, also known as strabismus, susceptibility to, 1, is related to esotropia and exotropia, and has symptoms including ophthalmoplegia, spasm of conjugate gaze and anomalies of divergence. An important gene associated with Strabismus is NALCN (Sodium Leak Channel, Non-Selective). The drugs Sevoflurane and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and thyroid, and related phenotypes are strabismus and behavior/neurological

Wikipedia : 76 Strabismus, also known as crossed eyes, is a condition in which the eyes do not properly align with each... more...

Related Diseases for Strabismus

Diseases related to Strabismus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
# Related Disease Score Top Affiliating Genes
1 esotropia 33.9 ADAT3 CHN1 SOBP TUBB3
2 exotropia 33.7 CHN1 PHOX2A TUBB3
3 paralytic squint 33.7 CHN1 PHOX2A TUBB3
4 hypertropia 33.1 CHN1 FGFR2 TUBB3
5 tukel syndrome 33.0 CHN1 PHOX2A TUBB3
6 amblyopia 32.7 CHN1 GALC SOBP TUBB3
7 hypotropia 32.5 CHN1 PHOX2A TUBB3
8 marcus gunn phenomenon 31.9 CHN1 TUBB3
9 ocular motility disease 31.8 CHN1 GPR143 PHOX2A TUBB3 VANGL2
10 congenital nystagmus 31.2 GPR143 TUBB3 TYR
11 congenital ptosis 30.1 CHN1 TUBB3
12 alacrima, achalasia, and mental retardation syndrome 29.6 DHX30 GNB1 MED13L MPP4
13 mental retardation, anterior maxillary protrusion, and strabismus 12.2
14 mechanical strabismus 12.2
15 hemifacial hyperplasia with strabismus 12.1
16 ptosis, strabismus, and ectopic pupils 12.1
17 speech development, delayed, with facial asymmetry, strabismus, and transverse earlobe crease 11.9
18 ptosis strabismus diastasis 11.8
19 severe intellectual disability-hypotonia-strabismus-coarse face-planovalgus syndrome 11.8
20 mehes syndrome 11.4
21 white-sutton syndrome 11.3
22 fourth cranial nerve palsy, familial congenital 11.3
23 upper thoracic spina bifida cystica 11.2 VANGL1 VANGL2
24 abducens nerve disease 11.2
25 crouzon syndrome 11.2
26 cervicothoracic spina bifida cystica 11.2 VANGL1 VANGL2
27 cervical spina bifida cystica 11.2 VANGL1 VANGL2
28 lumbosacral spina bifida cystica 11.2 VANGL1 VANGL2
29 mental retardation, autosomal recessive 36 11.2
30 thoracolumbosacral spina bifida cystica 11.1 VANGL1 VANGL2
31 fibrosis of extraocular muscles, congenital, 2 11.1
32 total spina bifida cystica 11.1 VANGL1 VANGL2
33 upper thoracic spina bifida aperta 11.1 VANGL1 VANGL2
34 retinoblastoma 11.1
35 thoracolumbosacral spina bifida aperta 11.1 VANGL1 VANGL2
36 brown syndrome 11.1
37 lumbosacral spina bifida aperta 11.1 VANGL1 VANGL2
38 cervical spina bifida aperta 11.1 VANGL1 VANGL2
39 cervicothoracic spina bifida aperta 11.0 VANGL1 VANGL2
40 total spina bifida aperta 11.0 VANGL1 VANGL2
41 duane retraction syndrome 1 11.0
42 fibrosis of extraocular muscles, congenital, 1 11.0
43 oculocutaneous albinism 10.9
44 congenital toxoplasmosis 10.9
45 cyclotropia 10.9
46 krauss herman holmes syndrome 10.9
47 arthrogryposis, distal, type 5 10.8
48 x-linked congenital stationary night blindness 10.8
49 pathologic nystagmus 10.8 GPR143 TUBB3
50 naegeli-franceschetti-jadassohn syndrome 10.8

Graphical network of the top 20 diseases related to Strabismus:



Diseases related to Strabismus

Symptoms & Phenotypes for Strabismus

Symptoms via clinical synopsis from OMIM:

57
Eyes:
microtropia
strabismus
cyclic strabismus (periodic esotrophia)


Clinical features from OMIM:

185100

Human phenotypes related to Strabismus:

32
# Description HPO Frequency HPO Source Accession
1 strabismus 32 HP:0000486

UMLS symptoms related to Strabismus:


ophthalmoplegia, spasm of conjugate gaze, anomalies of divergence

MGI Mouse Phenotypes related to Strabismus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 PCDH19 PHOX2A SOBP STXBP1 TYR VANGL2
2 cellular MP:0005384 10 CHN1 FGFR2 GALC GNB1 MPP4 PCDH19
3 mortality/aging MP:0010768 9.93 GNB1 NALCN PHOX2A STXBP1 TUBB3 TYR
4 nervous system MP:0003631 9.83 CHN1 DHX30 FGFR2 GALC GNB1 GPR143
5 respiratory system MP:0005388 9.17 FGFR2 GNB1 NALCN PHOX2A TUBB3 VANGL1

Drugs & Therapeutics for Strabismus

Drugs for Strabismus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Not Applicable 50-02-2 5743
3
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 2078-54-8 4943
4
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
5
Fluorometholone Approved, Investigational Phase 4 426-13-1 9878
6
Acetylcholine Approved Phase 4,Phase 3,Not Applicable 51-84-3 187
7
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
8
Ketamine Approved, Vet_approved Phase 4,Phase 2 6740-88-1 3821
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10
Midazolam Approved, Illicit Phase 4,Not Applicable 59467-70-8 4192
11
Iodine Approved, Investigational Phase 4,Not Applicable 7553-56-2 807
12
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
13
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
14
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
15
Rimexolone Approved Phase 4 49697-38-3 39507
16
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
17
Povidone Approved Phase 4,Not Applicable 9003-39-8
18
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
20 tannic acid Approved, Nutraceutical Phase 4,Not Applicable
21 Chlorhexidine gluconate Phase 4
22 Dexamethasone acetate Phase 4,Not Applicable 1177-87-3
23 Analgesics Phase 4,Phase 1,Phase 2,Not Applicable
24 glucocorticoids Phase 4,Not Applicable
25
protease inhibitors Phase 4,Not Applicable
26 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Not Applicable
27 Adjuvants, Anesthesia Phase 4,Phase 3,Not Applicable
28 Gastrointestinal Agents Phase 4,Phase 1,Phase 2,Not Applicable
29 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
30 Analgesics, Non-Narcotic Phase 4,Phase 1,Phase 2,Not Applicable
31 Tetrahydrozoline Phase 4,Not Applicable
32 HIV Protease Inhibitors Phase 4,Not Applicable
33 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
34 Hormone Antagonists Phase 4,Not Applicable
35 Anesthetics, General Phase 4,Phase 2,Not Applicable
36 Anesthetics, Inhalation Phase 4,Not Applicable
37 Anesthetics, Intravenous Phase 4,Phase 2,Not Applicable
38 Ophthalmic Solutions Phase 4,Not Applicable
39 Hormones Phase 4,Not Applicable
40 Disinfectants Phase 4
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Not Applicable
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Hypnotics and Sedatives Phase 4,Phase 2,Not Applicable
44 Platelet Aggregation Inhibitors Phase 4,Not Applicable
45 Anti-Infective Agents Phase 4,Not Applicable
46 Antiemetics Phase 4,Not Applicable
47 Anti-Infective Agents, Local Phase 4,Not Applicable
48 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2,Not Applicable
49 BB 1101 Phase 4,Not Applicable
50 Autonomic Agents Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 149)
# Name Status NCT ID Phase Drugs
1 Propofol for Treatment on Emergence Agitation Unknown status NCT02738814 Phase 4 propofol
2 Comparison of Intra Ocular Pressure After Insertion of the LMA Supreme and LMA Proseal in Pediatric Patients Unknown status NCT02508181 Phase 4
3 Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery Completed NCT01901588 Phase 4 Dexmedetomidine
4 Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery Completed NCT02816905 Phase 4 0.1 % Dexamethasone;0.1% Fluorometholone;1% Rimexolone
5 Comparison of Two Treatments for Strabismus Correction: Botulinum Toxin A Associated to Surgery and Surgery Alone Completed NCT01460355 Phase 4 Botulinum Toxin Type A;saline solution
6 The Effect of Anaesthesia Depth on Oculo-cardiac Reflex Completed NCT02379546 Phase 4 Desflurane
7 Povidone-iodine Antisepsis for Strabismus Surgery Completed NCT00461656 Phase 4 Preoperative conjunctival irrigation with 5% or 1.25% PI
8 Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children Completed NCT01895023 Phase 4 Dexmedetomidine;Midazolam;Saline
9 Intranasal Dexmedetomidine vs Midazolam-ketamine Combination for Premedication of Pediatric Patients Completed NCT02072083 Phase 4 Dexmedetomidine;Ketamine
10 Functional Effects of Botox on the Brain Using MRS and fMRI Completed NCT03373162 Phase 4 onabotulinumtoxinA
11 The Effect of Povidone-iodine Ophthalmic Surgical Prep Solution on Respiration in Children Undergoing Strabismus Surgery With General Anesthesia. Recruiting NCT03349515 Phase 4 Provodine-Iodine Solution;Group B will receive three drops in each eye of ophthalmic balanced salt solution.
12 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
13 Frontalis Botulinum Toxin Not yet recruiting NCT03186001 Phase 4 Abobotulinum toxin A
14 Vision In Preschoolers Study (VIP Study) Unknown status NCT00038753 Phase 3
15 A Trial of Bifocals in Myopic Children With Esophoria Unknown status NCT00000128 Phase 3
16 Efficacy and Safety of GSK1358820 (Botulinum Toxin Type A) in Patients With Strabismus Completed NCT01584843 Phase 3 GSK1358820
17 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
18 The Prism Adaptation Study (PAS) Completed NCT00000121 Phase 3
19 Amblyopia (Lazy Eye) Treatment Study Completed NCT00001864 Phase 3 Atropine
20 Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia Completed NCT00000170 Phase 3 Atropine
21 Trial to Evaluate 2 Hours of Daily Patching for Amblyopia in Children Completed NCT00091923 Phase 3
22 Orthoptic Changes Following Photorefractive Keratectomy Completed NCT01279993 Phase 3
23 Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds Completed NCT00315328 Phase 3 Atropine
24 Full-time Bangerter Filters Versus Part-time Daily Patching for Moderate Amblyopia in Children Completed NCT00525174 Phase 3
25 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
26 The Effect of Slanted Recession of Horizontal Muscle on Horizontal Strabismus With Abnormal Accommodative Convergence /Accommodation Ratio (AC/A) Recruiting NCT03555045 Phase 2, Phase 3
27 Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia Active, not recruiting NCT02371460 Phase 3
28 Botox Instead of Strabismus Surgery (BISS) Not yet recruiting NCT03459092 Phase 3 Botulinum toxin type A
29 ASIS for Enbrel in Plaque Psoriasis Unknown status NCT02112097 Phase 1, Phase 2 Gadolinium;Gadolinium;Gadolinium;Efficacy of Enbrel subcutaneously at Week 12;Efficacy of Enbrel subcutaneously at Week 24;Efficacy of Enbrel subcutaneously at Week 36;Efficacy of Enbrel subdermally at Week 12;Efficacy of Enbrel subdermally at Week 24;Efficacy of Enbrel subdermally at Week 36;PASI 75 n(%) subcutaneously at Week 12;PASI 75 n(%) subcutaneously at Week 24;PASI 75 n(%) subcutaneously at Week 36;PASI 75 n(%) subdermally at Week 12;PASI 75 n(%) subdermally at Week 24;PASI 75 n(%) subdermally at Week 36;Adverse Reactions of Enbrel subcutaneously;Adverse Reactions of Enbrel subdermally at Week 36;Gadolinium;Gadolinium;Gadolinium
30 Prevention of Complications of Eye Surgery Completed NCT00478907 Phase 2 KETAMINE, PROPOFOL, THIOPENTAL
31 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
32 Open-Label, Dose-Escalating Study Assessing Safety, Tolerability, Efficacy, of RP103 in Mitochondrial Disease Completed NCT02023866 Phase 2 Cysteamine Bitartrate
33 Grading Versus Classic Inferior Oblique Anterior Transposition in Patient With Asymmetric Dissociated Vertical Deviation Recruiting NCT03135938 Phase 1, Phase 2
34 Effect of Intravenous Nalbuphine on Emergence Agitation Not yet recruiting NCT03470077 Phase 2 IV nalbuphine 0.1 mg/kg with induction of anesthesia.;IV nalbuphine 0.1 mg/kg at the end of surgery.
35 Study of Non-surgical Treatment Versus Observation in Asian Children With Intermittent Exotropia Terminated NCT01267500 Phase 2
36 A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease Terminated NCT02473445 Phase 2 Cysteamine Bitartrate
37 The Effect of Vision Therapy/Orthoptic on Motor & Sensory Status of the 3 to 7 Years Old Strabismic Patients Unknown status NCT00917982 Phase 1
38 Monovision for the Treatment of Diplopia Completed NCT01426672 Phase 1
39 Assessment of Fibrin Glue in Pterygium Surgery and Other Forms of External Eye Surgery Completed NCT00344201 Phase 1
40 Visual Cortex Stimulation in Patients With Amblyopia Completed NCT00097162 Phase 1
41 Dichoptic Virtual Reality Therapy for Amblyopia in Adults Terminated NCT02246556 Phase 1
42 Comparison of Propofol 1mg/kg and Propofol 0.5mg/kg for Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery During Sevoflurane Anesthesia Unknown status NCT02152787 Not Applicable Injection of propofol 1.0mg/kg;propofol 0.5mg/kg;normal saline
43 Pain Medications in Children Undergoing Strabismus Surgery Unknown status NCT02789969 Not Applicable Hydromorphone;Fentanyl
44 Dexamethasone (Sterodex) Versus Loteprendol (Lotemax) Eye Drops Following Strabismus Surgery Unknown status NCT02825186 Not Applicable Loteprendol etabonate 0.5%;Dexamethasone 0.1%
45 The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years Unknown status NCT02810847 Not Applicable
46 The Effect of Remifentanil Infusion During Emergence on the Incidence of Emergence Delirium Unknown status NCT02108795 Not Applicable Remifentanil;Placebo
47 Surgery for Esotropia Under Topical Anesthesia Unknown status NCT00993174 Not Applicable
48 Determining the Efficacy of Full-time Occlusion Therapy in Severe Amblyopia at Different Ages Unknown status NCT02113709 Not Applicable
49 New Pediatric Patching Method to Improve Compliance Unknown status NCT02236351 Not Applicable
50 The Antigagging Effect of Granisetron (Kytril), an Antiemetic Drug, in Dental Situations Unknown status NCT00502437 Not Applicable GRANISETRON

Search NIH Clinical Center for Strabismus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Strabismus

Genetic tests related to Strabismus:

# Genetic test Affiliating Genes
1 Susceptibility to Strabismus 29
2 Strabismus 29

Anatomical Context for Strabismus

MalaCards organs/tissues related to Strabismus:

41
Eye, Testes, Thyroid, Brain, Cortex, Retina, Colon

Publications for Strabismus

Articles related to Strabismus:

(show top 50) (show all 1045)
# Title Authors Year
1
Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy. ( 29339065 )
2018
2
Binocular stereo acuity affects monocular three-dimensional shape perception in patients with strabismus. ( 29306865 )
2018
3
Position matching between the visual fields in strabismus. ( 29356815 )
2018
4
Effect of intravenous preoperative versus postoperative paracetamol on postoperative nausea and vomiting in patients undergoing strabismus surgery: A prospective randomized study. ( 29450877 )
2018
5
Strabismus Postoperative Instructions to Patients and Parents. ( 29796675 )
2018
6
Vergence and Strabismus in Neurodegenerative Disorders. ( 29867716 )
2018
7
Intramuscular Distribution of the Abducens Nerve in the Lateral Rectus Muscle for the Management of Strabismus. ( 29447480 )
2018
8
Clinical features of strabismus and nystagmus in bilateral congenital cataracts. ( 29862181 )
2018
9
Congenital Restrictive Strabismus. ( 29346468 )
2018
10
Our experience with strabismus surgery under topical anesthesia performed at a tertiary eye care center. ( 29380804 )
2018
11
Hypohidrotic ectodermal dysplasia with strabismus. ( 29573265 )
2018
12
The impact of strabismus surgery on gait pattern in patients with congenital or starting within one year of age strabismus. ( 29339174 )
2018
13
Amblyopia, Strabismus and Refractive Errors in Congenital Ptosis: a systematic review and meta-analysis. ( 29844360 )
2018
14
Dry eye disease in strabismus patients: Does eye deviation harm ocular surface? ( 29406988 )
2018
15
Adjustable Strabismus Surgery under Topical Anesthesia: Alignment in Supine vs Seated Position. ( 29313409 )
2018
16
The effect of amniotic membrane grafting on healing and wound strength after strabismus surgery in a rabbit model. ( 29225157 )
2018
17
One-Muscle Strabismus Surgery: A Review. ( 29913025 )
2018
18
Multiple-Choice Answer Form Completion Time in Children With Amblyopia and Strabismus. ( 29902312 )
2018
19
Sugammadex affects emergence agitation in children undergoing strabismus surgery. ( 29962259 )
2018
20
Efficacy and Safety of Loteprednol 0.5% and Fluorometholone 0.1% After Strabismus Surgery in Children. ( 29958057 )
2018
21
Endophthalmitis following Strabismus Surgery: IPOSC Global Study. ( 29966454 )
2018
22
Scleral dellen following strabismus surgery. ( 29848534 )
2018
23
Differentiating Acute and Subacute Vertical Strabismus Using Different Head Positions During the Upright-Supine Test. ( 29450486 )
2018
24
Transient ischemic attack characterized by external strabismus of the left eye: A case report. ( 29901646 )
2018
25
Botulinum toxin chemodenervation for childhood strabismus in England: National and local patterns of practice. ( 29902283 )
2018
26
Botulinum Toxin for the Treatment of Cyclic Strabismus in Children: Three Case Reports. ( 29452451 )
2018
27
Erratum for &amp;quot;Comparison of Minimally Invasive Strabismus (MISS) and Conventional Strabismus Surgery Using the Limbal Approach&amp;quot;. ( 29378080 )
2018
28
Strabismus surgery for diplopia in chronic progressive external ophthalmoplegia. ( 29582258 )
2018
29
Use of a Binocular Optical Coherence Tomography System to Evaluate Strabismus in Primary Position. ( 29852032 )
2018
30
Strabismus Recognition Using Eye-Tracking Data and Convolutional Neural Networks. ( 29854365 )
2018
31
The Effect of Botulinum Toxin Augmentation on Strabismus Surgery for Large-Angle InfantileA Esotropia. ( 29476725 )
2018
32
Congenital melanocytic naevus and congenital strabismus. ( 29808480 )
2018
33
Developing Binocular Optical Coherence Tomography for Strabismus: Not a Simple Task. ( 29852035 )
2018
34
Changes in conjunctival-scleral thickness after strabismus surgery measured with anterior segment optical coherence tomography. ( 29980870 )
2018
35
Endophthalmitis Following Pediatric Cataract Surgery: An International Pediatric Ophthalmology and Strabismus Council Global Perspective. ( 28991343 )
2018
36
Prevalence and risk factors of strabismus in children and adolescents in South Korea: Korea National Health and Nutrition Examination Survey, 2008-2011. ( 29444106 )
2018
37
Long-term follow-up of cryopreserved amniotic membrane transplant during strabismus reoperations: Up 85 months' follow-up. ( 29952631 )
2018
38
Improvement in Both Primary and Eccentric Ocular Alignment After Thyroid Eye Disease-Strabismus Surgery With Tenon's Recession. ( 29923963 )
2018
39
Food and Drug Administration, American Academy of Ophthalmology, American Academy of Optometry, American Association for Pediatric Ophthalmology and Strabismus, American Optometric Association, American Society of Cataract and Refractive Surgery, and Contact Lens Association of Ophthalmologists Co-Sponsored Workshop: Controlling the Progression of Myopia: Contact Lenses and Future Medical Devices. ( 29923881 )
2018
40
Deep lateral wall orbital decompression following strabismus surgery in patients with Type II ophthalmic Graves' disease. ( 29319400 )
2018
41
Comparison of three models of saccade disconjugacy in strabismus. ( 28904108 )
2017
42
Population-Based Incidence of Strabismus: Why Is It Important? ( 28859195 )
2017
43
Ocular Causes of Abnormal Head Position: Strabismus Clinic Data. ( 28845325 )
2017
44
Strabismus Incidence in a Danish Population-Based Cohort of Children. ( 28859196 )
2017
45
Surgical outcomes of unilateral recession-resection for vertical strabismus in patients with thyroid eye disease. ( 28089937 )
2017
46
Observations on the relationship between anisometropia, amblyopia and strabismus. ( 28404522 )
2017
47
A Strabismus Syndrome Causing Chronic Innocuous Headache. ( 28927675 )
2017
48
Expression of schizophrenia biomarkers in extraocular muscles from patients with strabismus: an explanation for the link between exotropia and schizophrenia? ( 29302405 )
2017
49
Plication as an alternative to resection in horizontal strabismus: A randomized clinical trial. ( 28905830 )
2017
50
Pedigree Analysis of Familial Primary Concomitant Horizontal Strabismus in Northern India. ( 28796570 )
2017

Variations for Strabismus

ClinVar genetic disease variations for Strabismus:

6
(show top 50) (show all 69)
# Gene Variation Type Significance SNP ID Assembly Location
1 TYR NM_000372.4(TYR): c.265T> C (p.Cys89Arg) single nucleotide variant Pathogenic rs28940877 GRCh37 Chromosome 11, 88911386: 88911386
2 TYR NM_000372.4(TYR): c.265T> C (p.Cys89Arg) single nucleotide variant Pathogenic rs28940877 GRCh38 Chromosome 11, 89178218: 89178218
3 DMBX1 NM_147192.2(DMBX1): c.367C> T (p.Arg123Trp) single nucleotide variant Likely pathogenic rs730882203 GRCh38 Chromosome 1, 46510953: 46510953
4 DMBX1 NM_147192.2(DMBX1): c.367C> T (p.Arg123Trp) single nucleotide variant Likely pathogenic rs730882203 GRCh37 Chromosome 1, 46976625: 46976625
5 SPART NM_001142294.1(SPART): c.1450dupA (p.Thr484Asnfs) duplication Likely pathogenic rs730882198 GRCh38 Chromosome 13, 36314260: 36314260
6 SPART NM_001142294.1(SPART): c.1450dupA (p.Thr484Asnfs) duplication Likely pathogenic rs730882198 GRCh37 Chromosome 13, 36888397: 36888397
7 NF1 NM_001042492.2(NF1): c.1987G> A (p.Gly663Arg) single nucleotide variant Uncertain significance rs140653372 GRCh37 Chromosome 17, 29552254: 29552254
8 NF1 NM_001042492.2(NF1): c.1987G> A (p.Gly663Arg) single nucleotide variant Uncertain significance rs140653372 GRCh38 Chromosome 17, 31225236: 31225236
9 STXBP1 NM_003165.3(STXBP1): c.364C> T (p.Arg122Ter) single nucleotide variant Pathogenic rs794727792 GRCh37 Chromosome 9, 130423419: 130423419
10 STXBP1 NM_003165.3(STXBP1): c.364C> T (p.Arg122Ter) single nucleotide variant Pathogenic rs794727792 GRCh38 Chromosome 9, 127661140: 127661140
11 PCDH19 NM_001184880.1(PCDH19): c.1091dupC (p.Tyr366Leufs) duplication Pathogenic rs758946412 GRCh37 Chromosome X, 99662505: 99662505
12 PCDH19 NM_001184880.1(PCDH19): c.1091dupC (p.Tyr366Leufs) duplication Pathogenic rs758946412 GRCh38 Chromosome X, 100407507: 100407507
13 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh37 Chromosome 1, 1737942: 1737942
14 GNB1 NM_002074.4(GNB1): c.239T> C (p.Ile80Thr) single nucleotide variant Pathogenic rs752746786 GRCh38 Chromosome 1, 1806503: 1806503
15 MED13L t(12;19)(q24.21;q12) Translocation Pathogenic NCBI36 Chromosome 12, 114971734: 114971744
16 MED13L t(12;19)(q24.21;q12) Translocation Pathogenic NCBI36 Chromosome 19, 35769937: 35769968
17 NALCN NM_052867.3(NALCN): c.3390G> A (p.Pro1130=) single nucleotide variant Pathogenic rs869312873 GRCh37 Chromosome 13, 101742197: 101742197
18 NALCN NM_052867.3(NALCN): c.3390G> A (p.Pro1130=) single nucleotide variant Pathogenic rs869312873 GRCh38 Chromosome 13, 101089846: 101089846
19 GNB1 NM_002074.4(GNB1): c.284T> C (p.Leu95Pro) single nucleotide variant Pathogenic rs869312824 GRCh37 Chromosome 1, 1736004: 1736004
20 GNB1 NM_002074.4(GNB1): c.284T> C (p.Leu95Pro) single nucleotide variant Pathogenic rs869312824 GRCh38 Chromosome 1, 1804565: 1804565
21 GNB1 NM_002074.4(GNB1): c.233A> G (p.Lys78Arg) single nucleotide variant Pathogenic rs869312823 GRCh38 Chromosome 1, 1806509: 1806509
22 GNB1 NM_002074.4(GNB1): c.233A> G (p.Lys78Arg) single nucleotide variant Pathogenic rs869312823 GRCh37 Chromosome 1, 1737948: 1737948
23 GNB1 NM_002074.4(GNB1): c.228T> G (p.Asp76Glu) single nucleotide variant Pathogenic rs869312822 GRCh37 Chromosome 1, 1737953: 1737953
24 GNB1 NM_002074.4(GNB1): c.228T> G (p.Asp76Glu) single nucleotide variant Pathogenic rs869312822 GRCh38 Chromosome 1, 1806514: 1806514
25 RSRC2 NM_023012.5(RSRC2): c.425G> A (p.Arg142Gln) single nucleotide variant Likely pathogenic rs752134549 GRCh37 Chromosome 12, 123001951: 123001951
26 RSRC2 NM_023012.5(RSRC2): c.425G> A (p.Arg142Gln) single nucleotide variant Likely pathogenic rs752134549 GRCh38 Chromosome 12, 122517404: 122517404
27 46;XY;t(1;5)(p35.3;q31.3)dn Translocation Pathogenic
28 46;XX;t(3;12)(q13.2;q14)dn Translocation Pathogenic
29 46;XX;inv(14)(q24.1q32.1)dn inversion Uncertain significance
30 46;XY;t(6;11)(p12.3;p14.2)dn Translocation Pathogenic
31 46;XX;inv(5)(q14q33)dn inversion Uncertain significance
32 46;X;t(X;3)(p21.3;p25.1)dn Translocation Pathogenic
33 46;XX;t(6;21)(q14;q21)dn Translocation Likely pathogenic
34 46;XX;t(2;10)(q22;22.3)dn Translocation Pathogenic
35 46;XX;ins(2;9)(q24.3;p22.1p24.3)dn Translocation Pathogenic
36 FOXP1 NM_001244810.1(FOXP1): c.1396C> G (p.Pro466Ala) single nucleotide variant Likely pathogenic rs1057518926 GRCh38 Chromosome 3, 70977675: 70977675
37 FOXP1 NM_001244810.1(FOXP1): c.1396C> G (p.Pro466Ala) single nucleotide variant Likely pathogenic rs1057518926 GRCh37 Chromosome 3, 71026826: 71026826
38 SOX5 NM_006940.5(SOX5): c.482-2A> C single nucleotide variant Likely pathogenic rs1057518845 GRCh38 Chromosome 12, 23755726: 23755726
39 SOX5 NM_006940.5(SOX5): c.482-2A> C single nucleotide variant Likely pathogenic rs1057518845 GRCh37 Chromosome 12, 23908660: 23908660
40 GALC NM_000153.3(GALC): c.850G> A (p.Gly284Ser) single nucleotide variant Pathogenic/Likely pathogenic rs377274761 GRCh38 Chromosome 14, 87968393: 87968393
41 GALC NM_000153.3(GALC): c.850G> A (p.Gly284Ser) single nucleotide variant Pathogenic/Likely pathogenic rs377274761 GRCh37 Chromosome 14, 88434737: 88434737
42 GALC NM_000153.3(GALC): c.196G> A (p.Ala66Thr) single nucleotide variant Likely pathogenic rs1057518843 GRCh38 Chromosome 14, 87988523: 87988523
43 GALC NM_000153.3(GALC): c.196G> A (p.Ala66Thr) single nucleotide variant Likely pathogenic rs1057518843 GRCh37 Chromosome 14, 88454867: 88454867
44 KIF7 NM_198525.2(KIF7): c.434A> C (p.Tyr145Ser) single nucleotide variant Likely pathogenic rs758361736 GRCh37 Chromosome 15, 90193067: 90193067
45 KIF7 NM_198525.2(KIF7): c.434A> C (p.Tyr145Ser) single nucleotide variant Likely pathogenic rs758361736 GRCh38 Chromosome 15, 89649836: 89649836
46 SMARCA4 NM_001128849.1(SMARCA4): c.1358C> T (p.Thr453Ile) single nucleotide variant Likely benign rs1057518862 GRCh38 Chromosome 19, 10991262: 10991262
47 SMARCA4 NM_001128849.1(SMARCA4): c.1358C> T (p.Thr453Ile) single nucleotide variant Likely benign rs1057518862 GRCh37 Chromosome 19, 11101938: 11101938
48 MPP4 NM_033066.2(MPP4): c.946T> C (p.Trp316Arg) single nucleotide variant Pathogenic rs1057519443 GRCh37 Chromosome 2, 202539978: 202539978
49 MPP4 NM_033066.2(MPP4): c.946T> C (p.Trp316Arg) single nucleotide variant Pathogenic rs1057519443 GRCh38 Chromosome 2, 201675255: 201675255
50 DHX30 NM_138615.2(DHX30): c.1478G> A (p.Arg493His) single nucleotide variant Pathogenic rs1057519436 GRCh37 Chromosome 3, 47888040: 47888040

Copy number variations for Strabismus from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 195555 5 152100000 155600000 Deletion AK124699 strabismus
2 195560 5 152100000 155600000 Deletion C5ORF21 strabismus
3 195565 5 152100000 155600000 Deletion C5ORF3 strabismus
4 195570 5 152100000 155600000 Deletion GALNT10 strabismus
5 195575 5 152100000 155600000 Deletion HAND1 strabismus
6 195580 5 152100000 155600000 Deletion MFAP3 strabismus
7 195585 5 152100000 155600000 Deletion NR2F1 strabismus
8 195590 5 152100000 155600000 Deletion SAP30L strabismus

Expression for Strabismus

Search GEO for disease gene expression data for Strabismus.

Pathways for Strabismus

GO Terms for Strabismus

Cellular components related to Strabismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome membrane GO:0033162 8.62 GPR143 TYR

Biological processes related to Strabismus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membranous septum morphogenesis GO:0003149 8.96 FGFR2 VANGL2
2 eye pigment biosynthetic process GO:0006726 8.62 GPR143 TYR

Sources for Strabismus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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