MCID: STR002
MIFTS: 41

Streptococcal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Streptococcal Meningitis

MalaCards integrated aliases for Streptococcal Meningitis:

Name: Streptococcal Meningitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11574
ICD10 33 G00.2
ICD9CM 35 320.2
SNOMED-CT 68 4510004
UMLS 73 C0154639

Summaries for Streptococcal Meningitis

MalaCards based summary : Streptococcal Meningitis is related to otitis media and meningitis. An important gene associated with Streptococcal Meningitis is EARS2 (Glutamyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Hematopoietic cell lineage. The drugs Amphotericin B and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and pituitary, and related phenotypes are hematopoietic system and cardiovascular system

Related Diseases for Streptococcal Meningitis

Diseases related to Streptococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 otitis media 30.4 CD40LG MBL2 TNF
2 meningitis 29.7 ADA CD40LG CFP CRP MBL2 TNF
3 bacterial meningitis 29.6 CFP CRP TNF
4 suppurative otitis media 29.5 CD40LG CRP
5 purpura 29.3 CD40LG CRP TNF
6 pneumonia 28.9 CD40LG CRP MBL2 TNF
7 myeloma, multiple 27.3 CD40LG CD44 CRP MYOM2 TNF
8 scabies 10.8 CFP MBL2
9 mannose-binding lectin deficiency 10.7 CFP MBL2
10 immunoglobulin g deficiency 10.7 CD40LG MBL2
11 adult dermatomyositis 10.7 MBL2 TNF
12 granulomatous dermatitis 10.7 NOD2 TNF
13 meningococcal meningitis 10.7 CFP MBL2
14 neisseria meningitidis infection 10.6 CFP IL1R1 MBL2
15 ileocolitis 10.6 NOD2 TNF
16 scarlet fever 10.6 MYOM2 SPEG
17 streptococcal toxic-shock syndrome 10.6 MYOM2 TNF
18 coccidioidomycosis 10.6 CD40LG MBL2
19 trench fever 10.6 CD40LG TNF
20 encephalitozoonosis 10.6 CD40LG TNF
21 rheumatoid lung disease 10.5 CD40LG TNF
22 schnitzler syndrome 10.5 CD40LG IL1R1
23 vulvar vestibulitis syndrome 10.5 IL1R1 MBL2 TNF
24 miller fisher syndrome 10.5 CD40LG TNF
25 papilledema 10.5 IL1R1 MYOM2
26 ocular toxoplasmosis 10.5 CD40LG NOD2
27 mononeuritis of upper limb and mononeuritis multiplex 10.5 CD40LG MYOM2
28 polyclonal hypergammaglobulinemia 10.5 CD40LG MYOM2
29 pyoderma 10.4 IL1R1 NOD2 TNF
30 pulmonary tuberculosis 10.4 ADA MBL2 TNF
31 iga glomerulonephritis 10.4 CD40LG CFP MBL2
32 chronic polyneuropathy 10.4 CD40LG MYOM2
33 peroneal neuropathy 10.4 EDN2 TNF
34 mycobacterium tuberculosis 1 10.4 ADA MBL2 TNF
35 cryopyrin-associated periodic syndrome 10.4 CRP IL1R1
36 rheumatic heart disease 10.4 MBL2 MYOM2 TNF
37 uveitis 10.4 IL1R1 NOD2 TNF
38 diffuse glomerulonephritis 10.4 CD40LG CFP
39 mastoiditis 10.4 CRP SPEG
40 abdominal tuberculosis 10.4 ADA CRP
41 sarcoidosis 1 10.4 ADA NOD2 TNF
42 murray valley encephalitis 10.3 CD40LG MYOM2
43 q fever 10.3 CD40LG NOD2 TNF
44 leprosy 3 10.2 CD40LG NOD2 TNF
45 acalculous cholecystitis 10.2 CD40LG CRP
46 immune deficiency disease 10.2 ADA CD40LG TNF
47 mononeuritis multiplex 10.2 CD40LG CRP
48 osteosclerotic myeloma 10.2 CD40LG MYOM2 TNF
49 monoclonal gammopathy of uncertain significance 10.2 CD40LG MYOM2 TNF
50 commensal bacterial infectious disease 10.2 CD40LG MYOM2 TNF

Graphical network of the top 20 diseases related to Streptococcal Meningitis:



Diseases related to Streptococcal Meningitis

Symptoms & Phenotypes for Streptococcal Meningitis

MGI Mouse Phenotypes related to Streptococcal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 MBL2 NOD2 SPEG SRR TNF ADA
2 cardiovascular system MP:0005385 9.97 ADA CD40LG CD44 CFP CRP IL1R1
3 homeostasis/metabolism MP:0005376 9.93 ADA CD40LG CD44 CFP CRP EDN2
4 immune system MP:0005387 9.73 ADA CD40LG CD44 CFP CRP IL1R1
5 renal/urinary system MP:0005367 9.1 CD44 IL1R1 MAPT MBL2 ADA CD40LG

Drugs & Therapeutics for Streptococcal Meningitis

Drugs for Streptococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 2 1397-89-3 14956 5280965
2
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Tamoxifen Approved Phase 2 10540-29-1 2733526
5 Anti-Bacterial Agents Phase 2
6 Antifungal Agents Phase 2
7 Anti-Infective Agents Phase 2
8 Antineoplastic Agents, Hormonal Phase 2
9 Antiparasitic Agents Phase 2
10 Antiprotozoal Agents Phase 2
11 Bone Density Conservation Agents Phase 2
12 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
13 Cytochrome P-450 CYP3A Inhibitors Phase 2
14 Cytochrome P-450 Enzyme Inhibitors Phase 2
15 Estrogen Antagonists Phase 2
16 Estrogen Receptor Modulators Phase 2
17 Estrogens Phase 2
18 Hormone Antagonists Phase 2
19 Hormones Phase 2
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
21 Liposomal amphotericin B Phase 2
22 Selective Estrogen Receptor Modulators Phase 2
23 Steroid Synthesis Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole

Search NIH Clinical Center for Streptococcal Meningitis

Genetic Tests for Streptococcal Meningitis

Anatomical Context for Streptococcal Meningitis

MalaCards organs/tissues related to Streptococcal Meningitis:

41
Bone, Brain, Pituitary, Neutrophil, Spinal Cord

Publications for Streptococcal Meningitis

Articles related to Streptococcal Meningitis:

(show top 50) (show all 179)
# Title Authors Year
1
Acute streptococcal meningitis presenting as bilateral conductive hearing loss. ( 29655501 )
2018
2
Multiple myeloma presenting with bilateral ankle pain (microangiopathy) and complicated by streptococcal meningitis and Pneumocystis carinii pneumonia. ( 28174184 )
2017
3
Group B streptococcal meningitis in a previously healthy man. ( 26759446 )
2016
4
A Nonpregnant Woman with Group B Streptococcal Meningitis and Multifocal Embolic Infarctions. ( 27819425 )
2016
5
Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India. ( 25745315 )
2015
6
Late-Onset Group B Streptococcal Meningitis in Infants. ( 26092542 )
2015
7
Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India. ( 26713032 )
2015
8
Late-onset Group B Streptococcal Meningitis, Potential Effectiveness of a Vaccine by Maternal Immunization? ( 26376311 )
2015
9
Late-onset group B streptococcal meningitis has cerebrovascular complications. ( 25919727 )
2015
10
Comparative Genomics of the Mucoid and Nonmucoid Strains of Streptococcus pyogenes, Isolated from the Same Patient with Streptococcal Meningitis. ( 25883280 )
2015
11
The first documented case of hemorrhagic stroke caused by Group B streptococcal meningitis. ( 26793476 )
2015
12
Presumed Group B Streptococcal Meningitis After Epidural Blood Patch. ( 26050248 )
2015
13
Group A streptococcal meningitis: emm type distribution and theoretical vaccine coverage in children. ( 26319426 )
2015
14
Group A Streptococcal meningitis in adults. ( 25614959 )
2015
15
Maternal and Fetal Death following Group A Streptococcal Meningitis in Mid-Term Pregnancy. ( 24883215 )
2014
16
Group B streptococcal meningitis in infants beyond the neonatal period. ( 23881480 )
2014
17
Group B streptococcal meningitis in an adult: A possible complication of olecranon bursitis. ( 25097614 )
2014
18
Group A streptococcal meningitis in children: French surveillance network from 2001 to 2012. ( 24008745 )
2013
19
Group a streptococcal meningitis in a patient with palmoplantar pustulosis. ( 24292762 )
2013
20
Group A streptococcal meningitis: a case report. ( 24177305 )
2013
21
A case of postpartum Group B streptococcal meningitis. ( 27579128 )
2012
22
Long-term outcomes of group B streptococcal meningitis. ( 22689869 )
2012
23
Viridans streptococcal meningitis following penetrating cervical injury. ( 21206253 )
2011
24
Molecular epidemiology of group B streptococcal meningitis in children beyond the neonatal period from Angola. ( 21474607 )
2011
25
Stroke patterns in neonatal group B streptococcal meningitis. ( 21397170 )
2011
26
Pneumocephalus; a rare presentation of streptococcal meningitis. ( 21963754 )
2011
27
Group-A-streptococcal meningitis in a 7-year-old child--a rare pathogen in a non-immune compromised patient. ( 22669958 )
2011
28
Group-A-streptococcal meningitis in a 7-year-old child--a rare pathogen in a non-immune compromised patient. ( 22674699 )
2011
29
Late-onset group B streptococcal meningitis in a neonate with early antibiotic prophylaxis. ( 20713290 )
2010
30
Clinical, microbiological and molecular characteristics of six cases of group A streptococcal meningitis in western Norway. ( 20465489 )
2010
31
Early outcomes of group B streptococcal meningitis in the 21st century. ( 20555292 )
2010
32
Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis. ( 19767158 )
2009
33
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance. ( 19019714 )
2009
34
Postpartum Group B streptococcal meningitis. ( 18296821 )
2008
35
Group A streptococcal meningitis in a pediatric patient. ( 19436512 )
2008
36
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. ( 18377371 )
2008
37
Neonatal group A streptococcal meningitis: a case report and review of the literature. ( 18710558 )
2008
38
Group B streptococcal meningitis in a middle-aged woman. ( 17536989 )
2007
39
Fatal Group A Streptococcal meningitis in an adult. ( 17582195 )
2007
40
Fatal afebrile streptococcal meningitis in a chronic alcoholic patient. ( 17157703 )
2007
41
Streptococcal meningitis following myelogram procedures. ( 17464927 )
2007
42
Severe, widespread vasculopathy in late-onset group B streptococcal meningitis. ( 18045311 )
2007
43
Cervical pregnancy complicated with group B streptococcal meningitis. ( 17674249 )
2007
44
Septic shock as a result of group A beta-hemolytic streptococcal meningitis with empyema in pregnancy. ( 17445816 )
2007
45
A case of group A streptococcal meningitis following acute otitis media. ( 16969237 )
2006
46
Group A streptococcal meningitis in a pediatric patient following cochlear implantation: report of the first case and review of the literature. ( 16272530 )
2005
47
Group B streptococcal meningitis in a patient with horizontal transmission: beware of toothbrushing on Sunday mornings. ( 15780419 )
2005
48
Group A streptococcal meningitis: case report and review of the literature. ( 16038740 )
2005
49
Postpartum maternal group B streptococcal meningitis. ( 15842217 )
2005
50
A 6-week-old girl with Group B streptococcal meningitis. ( 15462571 )
2004

Variations for Streptococcal Meningitis

Expression for Streptococcal Meningitis

Search GEO for disease gene expression data for Streptococcal Meningitis.

Pathways for Streptococcal Meningitis

GO Terms for Streptococcal Meningitis

Cellular components related to Streptococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.8 ADA CD40LG CFP CRP EDN2 MBL2
2 extracellular region GO:0005576 9.76 CD40LG CFP CRP EDN2 IL1R1 MAPT
3 external side of plasma membrane GO:0009897 9.26 ADA CD40LG IL1R1 TNF
4 cell surface GO:0009986 9.17 ADA CD40LG CD44 IL1R1 MBL2 NOD2

Biological processes related to Streptococcal Meningitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 CD40LG NOD2 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.61 CRP MBL2 TNF
3 positive regulation of smooth muscle contraction GO:0045987 9.54 ADA EDN2
4 regulation of inflammatory response GO:0050727 9.54 IL1R1 NOD2 TNF
5 positive regulation of heart rate GO:0010460 9.51 ADA EDN2
6 embryonic digestive tract development GO:0048566 9.49 ADA TNF
7 positive regulation of superoxide anion generation GO:0032930 9.48 CRP MAPT
8 negative regulation of growth of symbiont in host GO:0044130 9.46 MBL2 TNF
9 defense response to bacterium GO:0042742 9.46 CFP MBL2 NOD2 TNF
10 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.4 CD44 TNF
11 negative regulation of lipid storage GO:0010888 9.32 CRP TNF
12 opsonization GO:0008228 9.26 CRP MBL2
13 regulation of immunoglobulin secretion GO:0051023 8.96 CD40LG TNF
14 positive regulation of prostaglandin-endoperoxide synthase activity GO:0060585 8.62 EDN2 NOD2

Sources for Streptococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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