MCID: STR002
MIFTS: 36

Streptococcal Meningitis

Categories: Neuronal diseases

Aliases & Classifications for Streptococcal Meningitis

MalaCards integrated aliases for Streptococcal Meningitis:

Name: Streptococcal Meningitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11574
ICD10 33 G00.2
ICD9CM 35 320.2
SNOMED-CT 68 4510004
UMLS 73 C0154639

Summaries for Streptococcal Meningitis

Disease Ontology : 12 A bacterial meningitis that has material basis in streptococcal bacteria.

MalaCards based summary : Streptococcal Meningitis is related to meningitis and bacterial meningitis. An important gene associated with Streptococcal Meningitis is EARS2 (Glutamyl-TRNA Synthetase 2, Mitochondrial), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Hematopoietic cell lineage. The drugs Fluconazole and Tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and spinal cord, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Streptococcal Meningitis

Diseases related to Streptococcal Meningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.2 CFP CRP MBL2 TNF
2 bacterial meningitis 29.7 CFP CRP TNF
3 pneumonia 29.7 CRP MBL2 TNF
4 myeloma, multiple 29.1 CD44 CRP MYOM2 TNF
5 scabies 10.2 CFP MBL2
6 mannose-binding lectin deficiency 10.2 CFP MBL2
7 meningococcal meningitis 10.2 CFP MBL2
8 adult dermatomyositis 10.2 MBL2 TNF
9 ileocolitis 10.2 NOD2 TNF
10 granulomatous dermatitis 10.2 NOD2 TNF
11 meningococcemia 10.2 CFP MBL2
12 3mc syndrome 10.2 CFP MBL2
13 papilledema 10.2 IL1R1 MYOM2
14 streptococcal toxic-shock syndrome 10.2 MYOM2 TNF
15 scarlet fever 10.2 MYOM2 SPEG
16 crohn's colitis 10.2 NOD2 TNF
17 neisseria meningitidis infection 10.2 CFP IL1R1 MBL2
18 listeriosis 10.1 MBL2 TNF
19 peroneal neuropathy 10.1 EDN2 TNF
20 osteosclerotic myeloma 10.1 MYOM2 TNF
21 poems syndrome 10.1 MYOM2 TNF
22 spondylarthropathy 10.1 NOD2 TNF
23 vulvar vestibulitis syndrome 10.1 IL1R1 MBL2 TNF
24 inflammatory bowel disease 3 10.1 NOD2 TNF
25 cryopyrin-associated periodic syndrome 10.1 CRP IL1R1
26 pyoderma gangrenosum 10.1 IL1R1 NOD2 TNF
27 pyoderma 10.1 IL1R1 NOD2 TNF
28 mastoiditis 10.1 CRP SPEG
29 otitis media 10.1
30 schnitzler syndrome 10.1 CRP IL1R1
31 drug reaction with eosinophilia and systemic symptoms 10.1 CRP TNF
32 uveitis 10.1 IL1R1 NOD2 TNF
33 paratyphoid fever 10.1 CRP IL1R1
34 bacteremia 2 10.1 CRP MBL2
35 intestinal perforation 10.1 CRP NOD2
36 panencephalitis, subacute sclerosing 10.1 MAPT MYOM2
37 salpingitis 10.1 CRP TNF
38 mononeuritis multiplex 10.1 CRP MYOM2
39 rheumatic fever 10.1 MBL2 MYOM2 TNF
40 rheumatic heart disease 10.1 MBL2 MYOM2 TNF
41 burns 10.1 CRP TNF
42 melancholia 10.1 CRP TNF
43 hypersensitivity reaction type iv disease 10.1 MYOM2 NOD2 TNF
44 orofacial granulomatosis 10.1 NOD2 TNF
45 relapsing fever 10.1 CRP TNF
46 post-transplant lymphoproliferative disease 10.0 IL1R1 TNF
47 central nervous system vasculitis 10.0 CRP TNF
48 louse-borne relapsing fever 10.0 CRP TNF
49 tuberculous peritonitis 10.0 CRP TNF
50 mesenteric lymphadenitis 10.0 CRP NOD2

Graphical network of the top 20 diseases related to Streptococcal Meningitis:



Diseases related to Streptococcal Meningitis

Symptoms & Phenotypes for Streptococcal Meningitis

MGI Mouse Phenotypes related to Streptococcal Meningitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 CD44 EDN2 IL1R1 MAPT MBL2 NOD2
2 homeostasis/metabolism MP:0005376 9.65 CD44 CFP CRP EDN2 IL1R1 MAPT
3 immune system MP:0005387 9.32 CD44 CFP CRP IL1R1 MAPT MBL2

Drugs & Therapeutics for Streptococcal Meningitis

Drugs for Streptococcal Meningitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluconazole Approved, Investigational Phase 2 86386-73-4 3365
2
Tamoxifen Approved Phase 2 10540-29-1 2733526
3
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
4
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
5 Estrogen Antagonists Phase 2
6 Cytochrome P-450 Enzyme Inhibitors Phase 2
7 Anti-Bacterial Agents Phase 2
8 Liposomal amphotericin B Phase 2
9 Antiprotozoal Agents Phase 2
10 Steroid Synthesis Inhibitors Phase 2
11 Hormone Antagonists Phase 2
12 Cytochrome P-450 CYP2C19 Inhibitors Phase 2
13 Cytochrome P-450 CYP3A Inhibitors Phase 2
14 Antifungal Agents Phase 2
15 Cytochrome P-450 CYP2C9 Inhibitors Phase 2
16 Anti-Infective Agents Phase 2
17 Estrogens Phase 2
18 Selective Estrogen Receptor Modulators Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Estrogen Receptor Modulators Phase 2
21 Antineoplastic Agents, Hormonal Phase 2
22 Bone Density Conservation Agents Phase 2
23 Antiparasitic Agents Phase 2
24 Estrogen Receptor Antagonists Phase 2
25 Hormones Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Tamoxifen in Cryptococcal Meningitis Recruiting NCT03112031 Phase 2 Tamoxifen;Amphotericin B;Fluconazole

Search NIH Clinical Center for Streptococcal Meningitis

Genetic Tests for Streptococcal Meningitis

Anatomical Context for Streptococcal Meningitis

MalaCards organs/tissues related to Streptococcal Meningitis:

41
Brain, Pituitary, Spinal Cord, Neutrophil, Lung, Heart, Lymph Node

Publications for Streptococcal Meningitis

Articles related to Streptococcal Meningitis:

(show top 50) (show all 187)
# Title Authors Year
1
Acute streptococcal meningitis presenting as bilateral conductive hearing loss. ( 29655501 )
2018
2
Community-acquired group B streptococcal meningitis in adults: 33 cases from prospective cohort studies. ( 30063913 )
2018
3
Patterns of ischemic injury on brain images in neonatal group B Streptococcal meningitis. ( 30130950 )
2018
4
Brain imaging can predict neurodevelopmental outcome of Group B streptococcal meningitis in neonates. ( 30256462 )
2018
5
Multiple myeloma presenting with bilateral ankle pain (microangiopathy) and complicated by streptococcal meningitis and Pneumocystis carinii pneumonia. ( 28174184 )
2017
6
Group B streptococcal meningitis in a previously healthy man. ( 26759446 )
2016
7
A Nonpregnant Woman with Group B Streptococcal Meningitis and Multifocal Embolic Infarctions. ( 27819425 )
2016
8
Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India. ( 25745315 )
2015
9
Late-Onset Group B Streptococcal Meningitis in Infants. ( 26092542 )
2015
10
Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India. ( 26713032 )
2015
11
Late-onset Group B Streptococcal Meningitis, Potential Effectiveness of a Vaccine by Maternal Immunization? ( 26376311 )
2015
12
Late-onset group B streptococcal meningitis has cerebrovascular complications. ( 25919727 )
2015
13
Comparative Genomics of the Mucoid and Nonmucoid Strains of Streptococcus pyogenes, Isolated from the Same Patient with Streptococcal Meningitis. ( 25883280 )
2015
14
The first documented case of hemorrhagic stroke caused by Group B streptococcal meningitis. ( 26793476 )
2015
15
Presumed Group B Streptococcal Meningitis After Epidural Blood Patch. ( 26050248 )
2015
16
Group A streptococcal meningitis: emm type distribution and theoretical vaccine coverage in children. ( 26319426 )
2015
17
Group A Streptococcal meningitis in adults. ( 25614959 )
2015
18
Maternal and Fetal Death following Group A Streptococcal Meningitis in Mid-Term Pregnancy. ( 24883215 )
2014
19
Group B streptococcal meningitis in infants beyond the neonatal period. ( 23881480 )
2014
20
Group B streptococcal meningitis in an adult: A possible complication of olecranon bursitis. ( 25097614 )
2014
21
Group A streptococcal meningitis in children: French surveillance network from 2001 to 2012. ( 24008745 )
2013
22
Group a streptococcal meningitis in a patient with palmoplantar pustulosis. ( 24292762 )
2013
23
Group A streptococcal meningitis: a case report. ( 24177305 )
2013
24
A case of postpartum Group B streptococcal meningitis. ( 27579128 )
2012
25
Long-term outcomes of group B streptococcal meningitis. ( 22689869 )
2012
26
Viridans streptococcal meningitis following penetrating cervical injury. ( 21206253 )
2011
27
Molecular epidemiology of group B streptococcal meningitis in children beyond the neonatal period from Angola. ( 21474607 )
2011
28
Stroke patterns in neonatal group B streptococcal meningitis. ( 21397170 )
2011
29
Pneumocephalus; a rare presentation of streptococcal meningitis. ( 21963754 )
2011
30
Group-A-streptococcal meningitis in a 7-year-old child--a rare pathogen in a non-immune compromised patient. ( 22669958 )
2011
31
Group-A-streptococcal meningitis in a 7-year-old child--a rare pathogen in a non-immune compromised patient. ( 22674699 )
2011
32
Late-onset group B streptococcal meningitis in a neonate with early antibiotic prophylaxis. ( 20713290 )
2010
33
Clinical, microbiological and molecular characteristics of six cases of group A streptococcal meningitis in western Norway. ( 20465489 )
2010
34
Early outcomes of group B streptococcal meningitis in the 21st century. ( 20555292 )
2010
35
Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis. ( 19767158 )
2009
36
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance. ( 19019714 )
2009
37
Postpartum Group B streptococcal meningitis. ( 18296821 )
2008
38
Group A streptococcal meningitis in a pediatric patient. ( 19436512 )
2008
39
Transient isolated oculomotor nerve paralysis in neonatal group B streptococcal meningitis. ( 18377371 )
2008
40
Neonatal group A streptococcal meningitis: a case report and review of the literature. ( 18710558 )
2008
41
Group B streptococcal meningitis in a middle-aged woman. ( 17536989 )
2007
42
Fatal Group A Streptococcal meningitis in an adult. ( 17582195 )
2007
43
Fatal afebrile streptococcal meningitis in a chronic alcoholic patient. ( 17157703 )
2007
44
Streptococcal meningitis following myelogram procedures. ( 17464927 )
2007
45
Severe, widespread vasculopathy in late-onset group B streptococcal meningitis. ( 18045311 )
2007
46
Cervical pregnancy complicated with group B streptococcal meningitis. ( 17674249 )
2007
47
Septic shock as a result of group A beta-hemolytic streptococcal meningitis with empyema in pregnancy. ( 17445816 )
2007
48
A case of group A streptococcal meningitis following acute otitis media. ( 16969237 )
2006
49
Group A streptococcal meningitis in a pediatric patient following cochlear implantation: report of the first case and review of the literature. ( 16272530 )
2005
50
Group B streptococcal meningitis in a patient with horizontal transmission: beware of toothbrushing on Sunday mornings. ( 15780419 )
2005

Variations for Streptococcal Meningitis

Expression for Streptococcal Meningitis

Search GEO for disease gene expression data for Streptococcal Meningitis.

Pathways for Streptococcal Meningitis

GO Terms for Streptococcal Meningitis

Cellular components related to Streptococcal Meningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 CFP CRP EDN2 IL1R1 MAPT MBL2
2 cell surface GO:0009986 9.02 CD44 IL1R1 MBL2 NOD2 TNF

Biological processes related to Streptococcal Meningitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CD44 CRP IL1R1 TNF
2 defense response to Gram-positive bacterium GO:0050830 9.58 CRP MBL2 TNF
3 positive regulation of interleukin-8 production GO:0032757 9.52 NOD2 TNF
4 microglial cell activation GO:0001774 9.51 MAPT TNF
5 positive regulation of superoxide anion generation GO:0032930 9.48 CRP MAPT
6 negative regulation of growth of symbiont in host GO:0044130 9.46 MBL2 TNF
7 defense response to bacterium GO:0042742 9.46 CFP MBL2 NOD2 TNF
8 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.43 CD44 TNF
9 astrocyte activation GO:0048143 9.37 MAPT TNF
10 negative regulation of lipid storage GO:0010888 9.32 CRP TNF
11 opsonization GO:0008228 9.26 CRP MBL2
12 regulation of inflammatory response GO:0050727 9.13 IL1R1 NOD2 TNF
13 positive regulation of prostaglandin-endoperoxide synthase activity GO:0060585 8.62 EDN2 NOD2

Sources for Streptococcal Meningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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