MCID: STR077
MIFTS: 37

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 58
Streptococcal Toxic Shock Syndrome 71
Streptococcal Tss 58

Characteristics:

Orphanet epidemiological data:

58
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A48.3
UMLS via Orphanet 72 C0343532
Orphanet 58 ORPHA99918
UMLS 71 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to scarlet fever and impetigo. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 534)
# Related Disease Score Top Affiliating Genes
1 scarlet fever 30.8 TNF MYOM2
2 impetigo 30.7 MYOM2 IL6
3 peritonitis 30.6 TNF IL6 CXCL8
4 laryngitis 30.4 TNF IL6
5 myositis 30.4 TNF IL6 CXCL8
6 chickenpox 30.4 TNF IL6 IL2
7 septic arthritis 30.3 TNF IL6 CXCL8
8 gastritis 30.2 TNF IL6 CXCL8
9 adult respiratory distress syndrome 30.1 TNF IL6 CXCL8
10 cellulitis 30.1 TNF IL6 IL2
11 bacterial infectious disease 30.1 TNF IL6 CXCL8
12 vaginal discharge 30.0 TNF IL6 CXCL8
13 reactive arthritis 30.0 TNF IL6 CXCL8
14 pharyngitis 30.0 TNF MYOM2 IL6 CXCL8
15 cerebrovascular disease 29.9 TNF LTA IL6
16 vaginitis 29.8 TNF IL6 CXCL8
17 endometritis 29.8 TNF IL6 CXCL8
18 gastric ulcer 29.8 TNF IL6 CXCL8
19 pericarditis 29.8 TNF IL6 CXCL8
20 alcoholic hepatitis 29.8 TNF IL6 CXCL8
21 endocarditis 29.8 TNF IL6 CXCL8
22 osteomyelitis 29.8 TNF IL6 CXCL8
23 acute pancreatitis 29.7 TNF IL6 CXCL8
24 respiratory failure 29.7 TNF LTA IL6 CXCL8
25 exanthem 29.7 TNF IL6 IL2 CXCL8
26 rubella 29.5 TNF IL6 IL2
27 necrotizing fasciitis 29.5 MYOM2 LTA IL6 IL2 CXCL8
28 kawasaki disease 29.5 TNF IL6 IL2
29 diarrhea 29.4 TNF IL6 IL2 CXCL8
30 arthritis 29.4 TNF LTA IL6 CXCL8
31 tetanus 29.1 TNF LTA IL6 IL2
32 neutropenia 29.1 TNF IL6 IL2 CXCL8
33 toxic shock syndrome 29.1 TNF MYOM2 LTA IL6 IL2 CXCL8
34 fasciitis 29.1 TNF MYOM2 LTA IL6 IL2 CXCL8
35 erysipelas 29.0 TNF MYOM2 IL6 IL2
36 rheumatic fever 29.0 TNF MYOM2 IL6 IL2
37 pneumonia 28.9 TNF IL6 IL2 CXCL8
38 measles 28.9 TNF IL6 IL2 CXCL8
39 capillary leak syndrome 28.8 IL6 IL2 CXCL8 C1S
40 thrombocytopenia 28.8 TNF LTA IL6 IL2 CXCL8
41 cervical cancer 28.7 TNF IL6 IL2 CXCL8
42 rheumatoid arthritis 28.4 TNF LTA IL6 IL2 CXCL8
43 uveitis 28.4 TNF LTA IL6 IL2 CXCL8
44 systemic lupus erythematosus 27.8 TNF LTA IL6 IL2 CXCL8 C1S
45 disseminated intravascular coagulation 10.6
46 streptococcal group a invasive disease 10.5
47 purpura 10.4
48 purpura fulminans 10.3
49 staphylococcal toxic shock syndrome 10.3
50 staphylococcal scarlet fever 10.3

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
2 Epidemiological Surveillance in India of Group A Streptococcal Infections Including Pharyngitis and Impetigo Supported by Indo-US Vaccine Action Program Completed NCT00342199
3 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
4 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

40
Neutrophil, Lung, Skin, Heart, T Cells, Breast, Colon

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 639)
# Title Authors PMID Year
1
Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010-20171. 61
32442091 2020
2
Acquisition of genetic mutations in Group A Streptococci at infection site and subsequent systemic dissemination of the mutants with lethal mutations in a streptococcal toxic shock syndrome mouse model. 61
32135223 2020
3
A rare case of group A streptococcal toxic-shock syndrome in a postpartum adolescent leading to multi-organ failure. 61
32477519 2020
4
Clinical Description and Outcomes of Australian Children With Invasive Group A Streptococcal Disease. 61
32091492 2020
5
Invasive Group A streptococcal postpartum endometritis associated with multi-organ infarctions: an uncommon case presentation and literature review. 61
32379557 2020
6
Multisystemic Involvement: Streptococcal Toxic Shock Syndrome. 61
32277887 2020
7
Non-necrotizing soft tissue infection and streptococcal toxic shock syndrome caused by a novel Streptococcus pyogenes subtype (emm76.10). 61
32350222 2020
8
Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms. 61
31768707 2020
9
Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type. 61
32171281 2020
10
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response. 61
31650368 2020
11
T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017. 61
31735631 2020
12
Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014. 61
30462264 2020
13
[Invasive Eyelid Infections by β-Hemolytic Streptococci of Serogroup A]. 61
31509883 2020
14
Changes over an 8-year period in Streptococcus pyogenes emm types in pharyngeal isolates from non-invasive infection patients at a pediatric facility. 61
32009072 2020
15
Molecular Characterization of Streptococcus pyogenes Causing Invasive Disease in Pediatric Population in Spain A 12-year Study. 61
31738331 2019
16
Streptococcal toxic shock syndrome in a returning traveller. 61
30369302 2019
17
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. 61
30981616 2019
18
Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 61
31151810 2019
19
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome. 61
31772015 2019
20
["Tempus fugit, venit mors" - about streptococcal toxic shock syndrome: a case report and mini-review]. 61
31760775 2019
21
Streptococcal Toxic Shock Syndrome in a Patient with a Phlycten. 61
31858009 2019
22
Diagnosis and treatment of streptococcal toxic shock syndrome in the pediatric intensive care unit: a case report. 61
31967236 2019
23
Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs. 61
31335381 2019
24
Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition. 61
31403217 2019
25
Associations between common respiratory viruses and invasive group A streptococcal infection: A time-series analysis. 61
31237087 2019
26
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. 61
30085250 2019
27
Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal Toxic Shock Syndrome in Japan. 61
31196924 2019
28
Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. 61
30744988 2019
29
Periorbital necrotising fasciitis secondary to scratching. 61
30733068 2019
30
Another Fatality Due to Postpartum Group A Streptococcal Endometritis in the Modern Era. 61
31312545 2019
31
Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro. 61
30996209 2019
32
Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model. 61
30025835 2019
33
Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects. 61
30977463 2019
34
Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes. 61
30698306 2019
35
Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF. 61
30837977 2019
36
Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. 61
30881983 2019
37
Propionibacterium acnes Osteomyelitis after Intraosseous Cannulation in a Child. 61
31885985 2019
38
A Patient of Using Presepsin to Diagnose Streptococcal Toxic Shock Syndrome during Anticancer Drug Treatment. 61
31139474 2019
39
[Rapidly fatal streptococcal toxic shock syndrome due to Streptococcus agalactiae in a patient with chronic myeloid leukemia and cirrhosis]. 61
31484888 2019
40
Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. 61
30691408 2019
41
Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus. 61
30224551 2018
42
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. 61
29601458 2018
43
Streptococcus pyogenes bacteremia and toxic shock syndrome related to Strongyloides stercoralis hyperinfection: a case report. 61
30463627 2018
44
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. 61
29788397 2018
45
Epidemiology of an upsurge of invasive group A streptococcal infections in Ireland, 2012-2015. 61
29935196 2018
46
Fasciitis and Streptococcal Toxic-shock Syndrome: The Importance of Early Diagnosis and Surgical Management. 61
30740378 2018
47
Streptococcal toxic shock syndrome in the intensive care unit. 61
30225523 2018
48
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. 61
30170621 2018
49
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. 61
28426384 2018
50
[Streptococcal toxic shock syndrome caused by Streptococcus pyogenes: a retrospective study of 15 pediatric cases]. 61
30078239 2018

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 TNF LTA IL6 IL2 CXCL8
2
Show member pathways
13.21 TNF LTA IL6 IL2 CXCL8
3
Show member pathways
13.17 TNF LTA IL6 IL2 CXCL8
4
Show member pathways
13.12 TNF LTA IL6 IL2 CXCL8
5
Show member pathways
12.89 TNF IL6 IL2 CXCL8
6
Show member pathways
12.67 TNF IL6 IL2 CXCL8
7
Show member pathways
12.63 TNF LTA IL6 IL2
8
Show member pathways
12.62 TNF LTA IL6 IL2 CXCL8
9
Show member pathways
12.55 TNF LTA IL6 IL2
10
Show member pathways
12.21 TNF IL6 CXCL8
11
Show member pathways
12.2 TNF IL6 IL2
12
Show member pathways
12.18 TNF IL6 CXCL8
13 12.18 TNF IL6 CXCL8
14 12.15 TNF LTA IL6 IL2
15 12.14 TNF IL6 CXCL8
16
Show member pathways
12.14 TNF IL6 CXCL8
17 12.11 TNF IL6 CXCL8
18
Show member pathways
12.09 TNF IL6 IL2
19
Show member pathways
12.07 TNF IL6 CXCL8
20 12.05 TNF IL6 CXCL8
21 11.89 TNF IL6 IL2
22 11.88 TNF IL6 CXCL8
23 11.86 TNF LTA IL6
24
Show member pathways
11.86 TNF LTA IL6 IL2 CXCL8
25 11.83 TNF LTA CXCL8
26 11.81 TNF IL6 CXCL8
27 11.81 TNF IL6 IL2 CXCL8
28 11.79 TNF IL6 CXCL8
29 11.78 TNF IL6 IL2 CXCL8
30 11.76 TNF IL6 CXCL8
31
Show member pathways
11.69 LTA IL2 CXCL8
32 11.69 IL6 IL2 CXCL8
33 11.67 TNF LTA IL2
34
Show member pathways
11.65 TNF LTA IL6 IL2
35
Show member pathways
11.64 TNF IL2 CXCL8
36 11.62 TNF IL6 IL2
37 11.54 TNF IL6 CXCL8
38 11.49 TNF IL6 CXCL8
39 11.43 TNF IL6 IL2
40 11.41 TNF IL6 CXCL8
41 11.39 TNF IL6 CXCL8
42
Show member pathways
11.36 TNF LTA IL6 IL2 CXCL8
43 11.34 TNF IL6 CXCL8 C1S
44 11.29 TNF IL6
45
Show member pathways
11.27 TNF IL2
46 11.26 TNF IL6
47 11.25 IL6 CXCL8
48 11.21 TNF IL6
49 11.2 TNF IL6
50 11.12 LTA IL2

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TNF LTA IL6 IL2 CXCL8 C1S
2 extracellular space GO:0005615 9.1 TNF LTA IL6 IL2 CXCL8 C1S

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.72 TNF IL6 CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.67 TNF IL6 IL2 CXCL8
3 defense response to Gram-positive bacterium GO:0050830 9.63 TNF LTA IL6
4 positive regulation of JAK-STAT cascade GO:0046427 9.58 TNF IL6
5 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 TNF IL6 IL2
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.57 TNF IL6
8 positive regulation of chemokine production GO:0032722 9.56 TNF IL6
9 embryonic digestive tract development GO:0048566 9.54 TNF CXCL8
10 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 TNF IL6
11 positive regulation of neuroinflammatory response GO:0150078 9.51 TNF IL6
12 humoral immune response GO:0006959 9.5 TNF LTA IL6
13 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL6 IL2
14 negative regulation of lipid storage GO:0010888 9.48 TNF IL6
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.43 TNF LTA
16 positive regulation of interferon-gamma production GO:0032729 9.43 TNF LTA IL2
17 immune response GO:0006955 9.35 TNF LTA IL6 IL2 CXCL8
18 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 TNF LTA
19 positive regulation of glial cell proliferation GO:0060252 8.8 TNF LTA IL6

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA IL6 IL2 CXCL8
2 tumor necrosis factor receptor binding GO:0005164 8.96 TNF LTA

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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