MCID: STR077
MIFTS: 40

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 59
Streptococcal Toxic Shock Syndrome 73
Streptococcal Tss 59

Characteristics:

Orphanet epidemiological data:

59
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA99918
UMLS via Orphanet 74 C0343532
ICD10 via Orphanet 34 A48.3
UMLS 73 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to fasciitis and vaginitis. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include t cells, monocytes and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 fasciitis 30.8 CXCL8 IL6 TNF
2 vaginitis 30.5 CXCL8 IL6
3 infective endocarditis 30.5 IL6 TNF
4 pericarditis 30.4 IL6 TNF
5 reactive arthritis 30.4 IL6 TNF
6 peritonitis 30.4 CXCL8 IL6 TNF
7 impetigo 30.0 IL6 MYOM2
8 endocarditis 29.8 CXCL8 IL6 TNF
9 pharyngitis 29.7 CXCL8 MYOM2
10 arthritis 29.7 CXCL8 IL6 LTA TNF
11 rheumatoid arthritis 29.2 CXCL8 IL2 IL6 TNF
12 necrotizing fasciitis 28.4 CXCL8 IL2 IL6 LTA MYOM2
13 toxic shock syndrome 27.4 C1S CXCL8 IL2 IL6 LTA MYOM2
14 staphylococcal toxic shock syndrome 11.4
15 scorpion envenomation 10.6 IL6 TNF
16 leukomalacia 10.6 IL6 TNF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
18 critical limb ischemia 10.6 IL6 TNF
19 retinitis pigmentosa 55 10.6 IL6 TNF
20 anca-associated vasculitis 10.6 IL6 TNF
21 laryngitis 10.6 IL6 TNF
22 acute vascular insufficiency of intestine 10.6 IL6 TNF
23 posterior urethral valves 10.6 IL6 TNF
24 central nervous system vasculitis 10.6 IL6 TNF
25 stachybotrys chartarum 10.6 IL6 TNF
26 listeriosis 10.6 IL6 TNF
27 spondylarthropathy 10.5 LTA TNF
28 transient hypogammaglobulinemia 10.5 LTA TNF
29 ischemic heart disease 10.5 IL6 TNF
30 crimean-congo hemorrhagic fever 10.5 IL6 TNF
31 eales disease 10.5 IL6 TNF
32 hemorrhagic fever 10.5 IL6 TNF
33 idiopathic achalasia 10.5 LTA TNF
34 myelitis 10.5 IL6 TNF
35 stromal keratitis 10.5 IL6 TNF
36 recurrent corneal erosion 10.5 CXCL8 IL6
37 listeria meningitis 10.5 LTA TNF
38 sympathetic ophthalmia 10.5 LTA TNF
39 bagassosis 10.5 CXCL8 IL6
40 endometritis 10.5 IL6 TNF
41 acute transverse myelitis 10.5 CXCL8 IL6
42 rosacea 10.5 IL6 TNF
43 systolic heart failure 10.5 IL6 TNF
44 joint disorders 10.5 IL6 TNF
45 denture stomatitis 10.5 CXCL8 IL6
46 papillary conjunctivitis 10.5 CXCL8 IL6
47 localized scleroderma 10.5 IL6 TNF
48 juvenile spondyloarthropathy 10.5 IL2 LTA
49 funisitis 10.5 CXCL8 IL6
50 uremic pruritus 10.5 IL2 IL6

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
2 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
3 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

41
T Cells, Monocytes, Skin, Colon, Eye

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 193)
# Title Authors Year
1
Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis. ( 29788397 )
2018
2
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
3
Fulminant streptococcal toxic shock syndrome. ( 29741523 )
2018
4
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
5
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
6
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
7
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
8
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to <i>Streptococcus dysgalactiae</i> subsp. <i>equisimilis</i> Infection in a Hemodialysis Patient. ( 29457020 )
2017
9
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
10
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
11
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2017
12
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
13
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
14
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
15
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
16
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
17
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
18
Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage. ( 27579001 )
2016
19
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
20
Group A streptococcal toxic shock syndrome secondary to necrotizing pelvic inflammatory disease in a postmenopausal woman. ( 27419069 )
2016
21
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016
22
Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome. ( 27485878 )
2016
23
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. ( 27124845 )
2016
24
A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. ( 27553071 )
2016
25
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. ( 26025992 )
2015
26
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. ( 25703404 )
2015
27
Streptococcal toxic shock syndrome secondary to group AA Streptococcus vaginitis. ( 26386777 )
2015
28
Management of primary iliopsoas abscess in an immunocompetent patient followed by streptococcal toxic shock syndrome: A case report. ( 27489682 )
2015
29
Efficacy of Polyspecific Intravenous Immunoglobulin Therapy in Streptococcal Toxic Shock Syndrome. ( 25313253 )
2014
30
Phlegmonous gastritis associated with group a streptococcal toxic shock syndrome. ( 25400190 )
2014
31
Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. ( 24928291 )
2014
32
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
33
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24780814 )
2014
34
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. ( 25228196 )
2014
35
Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient. ( 24464696 )
2014
36
Cases of death due to serious group A streptococcal toxic shock syndrome in pregnant females in Japan. ( 25194311 )
2014
37
Case of streptococcal toxic shock syndrome caused by rapidly progressive group A hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer. ( 23937219 )
2014
38
Streptococcal toxic shock syndrome complicating a peritonsillar abscess. ( 25342572 )
2014
39
Necrotizing fasciitis and streptococcal toxic shock syndrome secondary to varicella in a healthy child. ( 25653688 )
2014
40
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. ( 23370754 )
2013
41
Streptococcal Toxic Shock Syndrome. ( 24297338 )
2013
42
Streptococcal toxic shock syndrome secondary to a deep neck space infection presenting with no throat or neck symptoms. ( 23709536 )
2013
43
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24112488 )
2013
44
Trivial trauma, lethal outcome: streptococcal toxic shock syndrome presenting to the ED. ( 23702056 )
2013
45
Fatal streptococcal toxic shock syndrome from an intrauterine device. ( 23394954 )
2013
46
Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome. ( 22965090 )
2012
47
Palpable purpura complicated by streptococcal toxic shock syndrome resulting in limb necrosis and amputation: a case of levamisole and cocaine coingestion. ( 22392427 )
2012
48
A case of streptococcal toxic shock syndrome due to Group G streptococci identified as Streptococcus dysgalactiae subsp. equisimilis. ( 22327489 )
2012
49
Travel-related Streptococcal toxic shock syndrome caused by emm type 78 Streptococcus pyogenes. ( 21632896 )
2011
50
Role of a type IV-like secretion system of Streptococcus suis 2 in the development of streptococcal toxic shock syndrome. ( 21673039 )
2011

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 C1S CXCL8 IL2 IL6 LTA TNF
2
Show member pathways
13.47 CXCL8 IL2 IL6 LTA TNF
3
Show member pathways
13.31 CXCL8 IL2 IL6 LTA TNF
4
Show member pathways
13.21 CXCL8 IL2 IL6 LTA TNF
5
Show member pathways
13.15 CXCL8 IL2 IL6 LTA TNF
6
Show member pathways
13.1 CXCL8 IL2 IL6 LTA TNF
7
Show member pathways
12.84 CXCL8 IL2 IL6 TNF
8
Show member pathways
12.73 IL2 IL6 LTA TNF
9
Show member pathways
12.6 CXCL8 IL2 IL6 LTA TNF
10
Show member pathways
12.54 IL2 IL6 LTA TNF
11
Show member pathways
12.45 CXCL8 IL2 IL6 LTA TNF
12
Show member pathways
12.43 IL2 IL6 TNF
13
Show member pathways
12.42 CXCL8 IL6 TNF
14
Show member pathways
12.31 IL2 IL6 TNF
15
Show member pathways
12.29 IL2 IL6 TNF
16 12.23 IL2 IL6 LTA TNF
17
Show member pathways
12.2 IL2 IL6 TNF
18
Show member pathways
12.2 CXCL8 IL6 TNF
19
Show member pathways
12.15 CXCL8 IL2 IL6 LTA TNF
20
Show member pathways
12.14 CXCL8 IL6 TNF
21
Show member pathways
12.13 CXCL8 IL6 TNF
22
Show member pathways
12.09 CXCL8 IL6 TNF
23
Show member pathways
12.08 IL2 IL6 TNF
24
Show member pathways
12.05 CXCL8 IL6 TNF
25 12.04 CXCL8 IL6 TNF
26
Show member pathways
12.01 IL2 IL6 LTA TNF
27 11.88 IL2 IL6 TNF
28 11.87 CXCL8 IL6 TNF
29 11.84 IL6 LTA TNF
30 11.79 CXCL8 IL6 TNF
31 11.77 CXCL8 IL6 TNF
32 11.76 CXCL8 LTA TNF
33 11.73 CXCL8 IL6 TNF
34 11.7 CXCL8 IL2 IL6 TNF
35
Show member pathways
11.69 CXCL8 IL2 LTA
36 11.67 CXCL8 IL2 IL6
37 11.66 IL2 LTA TNF
38
Show member pathways
11.62 CXCL8 IL2 TNF
39 11.6 IL2 IL6 TNF
40 11.52 CXCL8 IL6 TNF
41 11.46 LTA TNF
42 11.45 CXCL8 IL6 TNF
43 11.43 CXCL8 IL6
44
Show member pathways
11.42 LTA TNF
45 11.4 IL6 TNF
46 11.4 IL2 TNF
47 11.39 CXCL8 IL6
48 11.39 IL2 IL6 TNF
49 11.37 IL6 TNF
50 11.36 CXCL8 IL6 TNF

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 C1S CXCL8 IL2 IL6 LTA TNF
2 extracellular space GO:0005615 9.1 C1S CXCL8 IL2 IL6 LTA TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.75 IL6 LTA TNF
2 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL2 IL6 TNF
3 cellular response to lipopolysaccharide GO:0071222 9.67 CXCL8 IL6 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.61 IL6 LTA TNF
5 positive regulation of interleukin-6 production GO:0032755 9.57 IL6 TNF
6 negative regulation of fat cell differentiation GO:0045599 9.56 IL6 TNF
7 positive regulation of leukocyte chemotaxis GO:0002690 9.55 CXCL8 IL6
8 positive regulation of chemokine production GO:0032722 9.54 IL6 TNF
9 embryonic digestive tract development GO:0048566 9.52 CXCL8 TNF
10 negative regulation of growth of symbiont in host GO:0044130 9.51 LTA TNF
11 humoral immune response GO:0006959 9.5 IL6 LTA TNF
12 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL2 IL6
13 negative regulation of lipid storage GO:0010888 9.46 IL6 TNF
14 positive regulation of interferon-gamma production GO:0032729 9.43 IL2 LTA TNF
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.37 LTA TNF
16 immune response GO:0006955 9.35 CXCL8 IL2 IL6 LTA TNF
17 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
18 regulation of signaling receptor activity GO:0010469 9.02 CXCL8 IL2 IL6 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL2 IL6 LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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