MCID: STR077
MIFTS: 34

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 58
Streptococcal Toxic Shock Syndrome 70
Streptococcal Tss 58

Characteristics:

Orphanet epidemiological data:

58
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A48.3
UMLS via Orphanet 71 C0343532
Orphanet 58 ORPHA99918
UMLS 70 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to peritonitis and impetigo. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. Affiliated tissues include skin, bone and liver.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.7 TNF IL6 CXCL8
2 impetigo 30.7 MYOM2 IL6
3 scarlet fever 30.7 TNF MYOM2
4 cellulitis 30.6 TNF MYOM2 IL6
5 chickenpox 30.6 TNF IL6 IL2
6 adult respiratory distress syndrome 30.5 TNF IL6 CXCL8
7 laryngitis 30.4 TNF IL6
8 salpingitis 30.4 TNF IL6
9 pneumonia 30.3 TNF IL6 CXCL8
10 gastritis 30.3 TNF IL6 CXCL8
11 pharyngitis 30.3 TNF MYOM2 IL6 CXCL8
12 bacterial infectious disease 30.2 TNF IL6 CXCL8
13 vaginal discharge 30.2 TNF IL6 CXCL8
14 endocarditis 30.2 TNF IL6 CXCL8
15 reactive arthritis 30.2 TNF IL6 CXCL8
16 necrotizing fasciitis 30.1 MYOM2 LTA IL6 IL2 CXCL8
17 respiratory failure 30.0 TNF LTA IL6 CXCL8
18 exanthem 30.0 TNF IL6 IL2 CXCL8
19 disease by infectious agent 30.0 TNF LTA IL6 IL2
20 cerebrovascular disease 30.0 TNF LTA IL6
21 vaginitis 30.0 TNF IL6 CXCL8
22 endometritis 29.9 TNF IL6 CXCL8
23 toxic shock syndrome 29.9 TNF MYOM2 LTA IL6 IL2 CXCL8
24 gastric ulcer 29.9 TNF IL6 CXCL8
25 common cold 29.9 TNF IL6 CXCL8
26 pericarditis 29.9 TNF IL6 CXCL8
27 osteomyelitis 29.9 TNF IL6 CXCL8
28 alcoholic hepatitis 29.9 TNF IL6 CXCL8
29 myositis 29.9 TNF IL6 IL2 CXCL8
30 keratitis, hereditary 29.9 TNF IL6 CXCL8
31 aortic aneurysm, familial abdominal, 1 29.9 TNF IL6 CXCL8
32 acute pancreatitis 29.9 TNF IL6 CXCL8
33 fasciitis 29.8 TNF MYOM2 LTA IL6 IL2 CXCL8
34 rubella 29.8 TNF IL6 IL2
35 measles 29.7 TNF IL6 IL2
36 arthritis 29.6 TNF LTA IL6 CXCL8
37 diarrhea 29.6 TNF IL6 IL2 CXCL8
38 neutropenia 29.5 TNF IL6 IL2 CXCL8
39 tetanus 29.5 TNF LTA IL6 IL2
40 erysipelas 29.4 TNF MYOM2 IL6 IL2
41 rheumatic fever 29.4 TNF MYOM2 IL6 IL2
42 liver cirrhosis 29.3 TNF IL6 IL2 CXCL8
43 capillary leak syndrome 29.3 IL6 IL2 CXCL8 C1S
44 thrombocytopenia 29.2 TNF LTA IL6 IL2 CXCL8
45 rheumatoid arthritis 29.0 TNF LTA IL6 IL2 CXCL8
46 uveitis 29.0 TNF LTA IL6 IL2 CXCL8
47 disseminated intravascular coagulation 10.6
48 streptococcal group a invasive disease 10.5
49 purpura 10.4
50 septic arthritis 10.4

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Search Clinical Trials , NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

40
Skin, Bone, Liver, Heart, Kidney, Lung, Myeloid

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 662)
# Title Authors PMID Year
1
Early intravenous immunoglobulin therapy for group A β-haemolytic streptococcal meningitis with toxic shock syndrome. 61
33664027 2021
2
Molecular characterization and antimicrobial resistance of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2013 to 2018. 61
33756191 2021
3
Nationwide study of mortality and survival in pregnancy-related streptococcal toxic shock syndrome. 61
33350021 2021
4
Necrotizing Fasciitis Shock Syndrome by Group A Hemolytic Streptococcus: Report of 6 Cases and Clinical Management. 61
33739051 2021
5
Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase. 61
33563838 2021
6
Streptococcal toxic shock syndrome with fatal outcome: Report on four forensic autopsy cases. 61
33578046 2021
7
Tailored liposomal nanotraps for the treatment of Streptococcal infections. 61
33588835 2021
8
A case report of streptococcal toxic shock syndrome caused by Streptococcus mitis in a healthy adult. 61
33549044 2021
9
Genetics, Structure, and Function of Group A Streptococcal Pili. 61
33633705 2021
10
Screening for phagocytosis resistance-related genes via a transposon mutant library of Streptococcus suis serotype 2. 61
32614642 2020
11
Pneumatocele formation in a fatal adult pneumonia patient coinfected with Streptococcus pyogenes emm-type 3 and influenza A: a case report. 61
33243155 2020
12
Retiform Purpura as a Sign of Necrotizing Cellulitis in an Immunocompetent Boy. 61
32970024 2020
13
Outcomes of β-Hemolytic Streptococcal Necrotizing Skin and Soft-tissue Infections and the Impact of Clindamycin Resistance. 61
33151283 2020
14
Gastrointestinal mucormycosis due to Rhizopus microsporus following Streptococcus pyogenes toxic shock syndrome in an HIV patient: a case report. 61
33167878 2020
15
Multisystemic Involvement: Streptococcal Toxic Shock Syndrome. 61
32277887 2020
16
Streptococcal toxic shock syndrome revealed phlegmasia cerulea dolens of the arm. 61
33098783 2020
17
Quantitative proteomics revealed modulation of macrophages by MetQ gene of Streptococcus suis serotype 2. 61
33125582 2020
18
Change during an 8-Year Period in Streptococcus Pyogenes emm Types in Pharyngeal Isolates from Children with Noninvasive Infections. 61
32009072 2020
19
An anti-perfringolysin O monoclonal antibody cross-reactive with streptolysin O protects against streptococcal toxic shock syndrome. 61
32891180 2020
20
Non-Necrotizing Soft Tissue Infection and Streptococcal Toxic Shock Syndrome Caused by a Novel Streptococcus pyogenes Subtype (emm76.10). 61
32350222 2020
21
Invasive Group A streptococcal postpartum endometritis associated with multi-organ infarctions: an uncommon case presentation and literature review. 61
32379557 2020
22
Invasive Group A Streptococcal Infections Among People Who Inject Drugs and People Experiencing Homelessness in the United States, 2010-2017. 61
32803254 2020
23
Manifestations of Toxic Shock Syndrome in Children, Columbus, Ohio, USA, 2010-20171. 61
32442091 2020
24
Acquisition of genetic mutations in Group A Streptococci at infection site and subsequent systemic dissemination of the mutants with lethal mutations in a streptococcal toxic shock syndrome mouse model. 61
32135223 2020
25
A rare case of group A streptococcal toxic-shock syndrome in a postpartum adolescent leading to multi-organ failure. 61
32477519 2020
26
Clinical Description and Outcomes of Australian Children With Invasive Group A Streptococcal Disease. 61
32091492 2020
27
Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms. 61
31768707 2020
28
Human infection caused by Streptococcus suis serotype 2 in China: report of two cases and epidemic distribution based on sequence type. 61
32171281 2020
29
Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014. 61
30462264 2020
30
T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017. 61
31735631 2020
31
[Invasive Eyelid Infections by β-Hemolytic Streptococci of Serogroup A]. 61
31509883 2020
32
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response. 61
31650368 2020
33
Early surgery for limb preservation in Group A Streptococcus-induced necrotizing soft tissue infection and subsequent soft tissue infection: A case report. 61
33204629 2020
34
Novel Hyaluronate Lyase Involved in Pathogenicity of Streptococcus dysgalactiae subsp. equisimilis. 61
33072013 2020
35
Treatment of Necrotizing Soft Tissue Infections: IVIG. 61
33079366 2020
36
Streptococcal toxic shock syndrome in a patient with community-acquired pneumonia. Impact of rapid diagnostics on patient management. 61
32974603 2020
37
Infected abdominal aorta aneurysm secondary to streptococcal toxic shock syndrome due to Streptococcus pyogenes: a case report from Japan. 61
33364037 2020
38
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. 61
30981616 2019
39
Molecular Characterization of Streptococcus pyogenes Causing Invasive Disease in Pediatric Population in Spain A 12-year Study. 61
31738331 2019
40
Streptococcal toxic shock syndrome in a returning traveller. 61
30369302 2019
41
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome. 61
31772015 2019
42
Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 61
31151810 2019
43
["Tempus fugit, venit mors" - about streptococcal toxic shock syndrome: a case report and mini-review]. 61
31760775 2019
44
Streptococcal Toxic Shock Syndrome in a Patient with a Phlycten. 61
31858009 2019
45
Diagnosis and treatment of streptococcal toxic shock syndrome in the pediatric intensive care unit: a case report. 61
31967236 2019
46
Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition. 61
31403217 2019
47
Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs. 61
31335381 2019
48
Associations between common respiratory viruses and invasive group A streptococcal infection: A time-series analysis. 61
31237087 2019
49
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. 61
30085250 2019
50
Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal Toxic Shock Syndrome in Japan. 61
31196924 2019

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.34 TNF LTA IL6 IL2 CXCL8
2
Show member pathways
13.22 TNF LTA IL6 IL2 CXCL8
3
Show member pathways
13.17 TNF LTA IL6 IL2 CXCL8
4
Show member pathways
13.12 TNF LTA IL6 IL2 CXCL8
5
Show member pathways
12.67 TNF IL6 IL2 CXCL8
6
Show member pathways
12.64 TNF LTA IL6 IL2
7
Show member pathways
12.62 TNF LTA IL6 IL2 CXCL8
8
Show member pathways
12.55 TNF LTA IL6 IL2
9
Show member pathways
12.29 TNF IL6 CXCL8
10
Show member pathways
12.21 TNF IL6 IL2
11
Show member pathways
12.21 TNF IL6 CXCL8
12
Show member pathways
12.18 TNF IL6 CXCL8
13 12.15 TNF LTA IL6 IL2
14
Show member pathways
12.14 TNF IL6 CXCL8
15 12.12 TNF IL6 CXCL8
16
Show member pathways
12.1 TNF IL6 CXCL8
17
Show member pathways
12.09 TNF IL6 IL2
18
Show member pathways
12.07 TNF IL6 CXCL8
19 12.05 TNF IL6 CXCL8
20
Show member pathways
11.93 TNF LTA IL6 IL2 CXCL8
21 11.89 TNF IL6 IL2
22 11.88 TNF IL6 CXCL8
23 11.87 TNF LTA IL6
24 11.87 TNF IL6 IL2 CXCL8
25 11.83 TNF LTA CXCL8
26 11.81 TNF IL6 CXCL8
27 11.8 TNF IL6 CXCL8
28 11.78 TNF IL6 IL2 CXCL8
29 11.76 TNF IL6 CXCL8
30
Show member pathways
11.71 LTA IL2 CXCL8
31 11.69 IL6 IL2 CXCL8
32 11.68 TNF LTA IL2
33
Show member pathways
11.65 TNF IL2 CXCL8
34 11.63 TNF IL6 IL2
35 11.57 TNF LTA IL6
36 11.54 TNF IL6 CXCL8
37 11.49 TNF IL6 CXCL8
38
Show member pathways
11.44 TNF LTA IL6 IL2
39 11.43 TNF IL6 IL2
40 11.41 TNF IL6 CXCL8
41 11.39 TNF IL6 CXCL8
42
Show member pathways
11.36 TNF LTA IL6 IL2 CXCL8
43 11.34 TNF IL6 CXCL8 C1S
44 11.29 TNF IL6
45
Show member pathways
11.27 TNF IL2
46 11.26 TNF IL6
47 11.25 IL6 CXCL8
48 11.21 TNF IL6
49 11.2 TNF IL6
50 11.12 LTA IL2

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TNF LTA IL6 IL2 CXCL8 C1S
2 extracellular space GO:0005615 9.1 TNF LTA IL6 IL2 CXCL8 C1S

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.72 TNF IL6 CXCL8
2 cytokine-mediated signaling pathway GO:0019221 9.67 TNF IL6 IL2 CXCL8
3 defense response to Gram-positive bacterium GO:0050830 9.65 TNF LTA IL6
4 positive regulation of chemokine production GO:0032722 9.6 TNF IL6
5 positive regulation of JAK-STAT cascade GO:0046427 9.59 TNF IL6
6 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6
7 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.58 TNF IL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 TNF IL6 IL2
9 positive regulation of immunoglobulin production GO:0002639 9.57 IL6 IL2
10 positive regulation of interleukin-17 production GO:0032740 9.56 IL6 IL2
11 embryonic digestive tract development GO:0048566 9.54 TNF CXCL8
12 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.52 TNF IL6
13 positive regulation of neuroinflammatory response GO:0150078 9.51 TNF IL6
14 positive regulation of interferon-gamma production GO:0032729 9.5 TNF LTA IL2
15 negative regulation of lipid storage GO:0010888 9.49 TNF IL6
16 vascular endothelial growth factor production GO:0010573 9.46 TNF IL6
17 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.43 TNF LTA
18 humoral immune response GO:0006959 9.43 TNF LTA IL6
19 immune response GO:0006955 9.35 TNF LTA IL6 IL2 CXCL8
20 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 TNF LTA
21 positive regulation of glial cell proliferation GO:0060252 8.8 TNF LTA IL6

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA IL6 IL2 CXCL8
2 tumor necrosis factor receptor binding GO:0005164 8.96 TNF LTA

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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