MCID: STR077
MIFTS: 37

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 58
Streptococcal Toxic Shock Syndrome 71
Streptococcal Tss 58

Characteristics:

Orphanet epidemiological data:

58
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 A48.3
UMLS via Orphanet 72 C0343532
Orphanet 58 ORPHA99918
UMLS 71 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to scarlet fever and impetigo. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are TGF-Beta Pathway and Akt Signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include lung, bone and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 498)
# Related Disease Score Top Affiliating Genes
1 scarlet fever 30.8 TNF MYOM2
2 impetigo 30.7 MYOM2 IL6
3 peritonitis 30.6 TNF IL6 CXCL8
4 vaginal discharge 30.4 IL6 CXCL8
5 laryngitis 30.4 TNF IL6
6 chickenpox 30.4 TNF IL6 IL2
7 gastritis 30.2 TNF IL6 CXCL8
8 adult respiratory distress syndrome 30.1 TNF IL6 CXCL8
9 bacterial infectious disease 30.1 TNF IL6 CXCL8
10 reactive arthritis 30.0 TNF IL6 CXCL8
11 pharyngitis 30.0 TNF MYOM2 IL6 CXCL8
12 vaginitis 29.8 TNF IL6 CXCL8
13 endometritis 29.8 TNF IL6 CXCL8
14 gastric ulcer 29.8 TNF IL6 CXCL8
15 pericarditis 29.8 TNF IL6 CXCL8
16 keratitis, hereditary 29.8 TNF IL6 CXCL8
17 alcoholic hepatitis 29.8 TNF IL6 CXCL8
18 osteomyelitis 29.8 TNF IL6 CXCL8
19 endocarditis 29.8 TNF IL6 CXCL8
20 acute pancreatitis 29.8 TNF IL6 CXCL8
21 respiratory failure 29.7 TNF LTA IL6 CXCL8
22 exanthem 29.7 TNF IL6 IL2 CXCL8
23 rubella 29.6 TNF IL6 IL2
24 necrotizing fasciitis 29.5 MYOM2 LTA IL6 IL2 CXCL8
25 fasciitis 29.5 TNF MYOM2 IL6 IL2 CXCL8
26 myositis 29.5 TNF IL6 IL2 CXCL8
27 end stage renal failure 29.5 TNF IL6 IL2
28 measles 29.5 TNF IL6 IL2
29 diarrhea 29.5 TNF IL6 IL2 CXCL8
30 arthritis 29.4 TNF LTA IL6 CXCL8
31 thrombocytopenia 29.2 TNF IL6 IL2 CXCL8
32 tetanus 29.1 TNF LTA IL6 IL2
33 toxic shock syndrome 29.1 TNF MYOM2 LTA IL6 IL2 CXCL8
34 erysipelas 29.0 TNF MYOM2 IL6 IL2
35 rheumatic fever 29.0 TNF MYOM2 IL6 IL2
36 pneumonia 28.9 TNF IL6 IL2 CXCL8
37 capillary leak syndrome 28.8 IL6 IL2 CXCL8 C1S
38 cervical cancer 28.7 TNF IL6 IL2 CXCL8
39 rheumatoid arthritis 28.4 TNF LTA IL6 IL2 CXCL8
40 uveitis 28.4 TNF LTA IL6 IL2 CXCL8
41 systemic lupus erythematosus 27.8 TNF LTA IL6 IL2 CXCL8 C1S
42 disseminated intravascular coagulation 10.6
43 streptococcal group a invasive disease 10.5
44 purpura 10.4
45 cellulitis 10.4
46 septic arthritis 10.4
47 purpura fulminans 10.3
48 staphylococcal toxic shock syndrome 10.3
49 staphylococcal scarlet fever 10.3
50 external pathological resorption 10.3 TNF IL6

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
2 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
3 Epidemiological Surveillance in India of Group A Streptococcal Infections Including Pharyngitis and Impetigo Supported by Indo-US Vaccine Action Program Completed NCT00342199
4 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

40
Lung, Bone, Skin, Liver, Neutrophil, Heart, Thyroid

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 630)
# Title Authors PMID Year
1
T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017. 61
31735631 2020
2
Isorhamnetin attenuates Streptococcus suis virulence by inhibiting the inflammatory response. 61
31650368 2020
3
Changes over an 8-year period in Streptococcus pyogenes emm types in pharyngeal isolates from non-invasive infection patients at a pediatric facility. 61
32009072 2020
4
Molecular Characterization of Streptococcus pyogenes Causing Invasive Disease in Pediatric Population in Spain A 12-year Study. 61
31738331 2019
5
Streptococcal toxic shock syndrome in a returning traveller. 61
30369302 2019
6
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. 61
30981616 2019
7
Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 61
31151810 2019
8
MAIT Cells Are Major Contributors to the Cytokine Response in Group A Streptococcal Toxic Shock Syndrome. 61
31772015 2019
9
["Tempus fugit, venit mors" - about streptococcal toxic shock syndrome: a case report and mini-review]. 61
31760775 2019
10
Clindamycin inhibits nociceptive response by reducing tumor necrosis factor-α and CXCL-1 production and activating opioidergic mechanisms. 61
31768707 2019
11
Streptococcal Toxic Shock Syndrome in a Patient with a Phlycten. 61
31858009 2019
12
Diagnosis and treatment of streptococcal toxic shock syndrome in the pediatric intensive care unit: a case report. 61
31967236 2019
13
Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs. 61
31335381 2019
14
Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition. 61
31403217 2019
15
Associations between common respiratory viruses and invasive group A streptococcal infection: A time-series analysis. 61
31237087 2019
16
[Invasive Eyelid Infections by β-Hemolytic Streptococci of Serogroup A]. 61
31509883 2019
17
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. 61
30085250 2019
18
Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal Toxic Shock Syndrome in Japan. 61
31196924 2019
19
Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. 61
30744988 2019
20
Periorbital necrotising fasciitis secondary to scratching. 61
30733068 2019
21
Another Fatality Due to Postpartum Group A Streptococcal Endometritis in the Modern Era. 61
31312545 2019
22
Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro. 61
30996209 2019
23
Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model. 61
30025835 2019
24
Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects. 61
30977463 2019
25
Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes. 61
30698306 2019
26
Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF. 61
30837977 2019
27
Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. 61
30881983 2019
28
Propionibacterium acnes Osteomyelitis after Intraosseous Cannulation in a Child. 61
31885985 2019
29
A Patient of Using Presepsin to Diagnose Streptococcal Toxic Shock Syndrome during Anticancer Drug Treatment. 61
31139474 2019
30
[Rapidly fatal streptococcal toxic shock syndrome due to Streptococcus agalactiae in a patient with chronic myeloid leukemia and cirrhosis]. 61
31484888 2019
31
Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. 61
30691408 2019
32
Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus. 61
30224551 2018
33
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. 61
29601458 2018
34
Streptococcus pyogenes bacteremia and toxic shock syndrome related to Strongyloides stercoralis hyperinfection: a case report. 61
30463627 2018
35
Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014. 61
30462264 2018
36
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. 61
29788397 2018
37
Epidemiology of an upsurge of invasive group A streptococcal infections in Ireland, 2012-2015. 61
29935196 2018
38
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. 61
30170621 2018
39
Fasciitis and Streptococcal Toxic-shock Syndrome: The Importance of Early Diagnosis and Surgical Management. 61
30740378 2018
40
Streptococcal toxic shock syndrome in the intensive care unit. 61
30225523 2018
41
[Streptococcal toxic shock syndrome caused by Streptococcus pyogenes: a retrospective study of 15 pediatric cases]. 61
30078239 2018
42
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. 61
28426384 2018
43
[Investigation of Streptococcus pyogenes virulence factors and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method]. 61
30156510 2018
44
Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases. 61
29722472 2018
45
Invasive disease by Streptococcus pyogenes: patients hospitalized for 6 years. 61
28705427 2018
46
Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection. 61
29581121 2018
47
A case report of hemolytic streptococcal gangrene in the danger triangle of the face with thrombocytopenia and hepatitis. 61
29933752 2018
48
Fulminant streptococcal toxic shock syndrome. 61
29741523 2018
49
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. 61
29107650 2018
50
An aggressive and fatal craniofacial group A Streptococcus infection resulting from a minimally displaced orbital floor fracture. 61
28803736 2018

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 TNF LTA IL6 IL2 CXCL8
2
Show member pathways
13.22 TNF LTA IL6 IL2 CXCL8
3
Show member pathways
13.18 TNF LTA IL6 IL2 CXCL8
4
Show member pathways
13.12 TNF LTA IL6 IL2 CXCL8
5
Show member pathways
12.96 TNF IL6 IL2 CXCL8
6
Show member pathways
12.67 TNF IL6 IL2 CXCL8
7
Show member pathways
12.64 TNF LTA IL6 IL2
8
Show member pathways
12.62 TNF LTA IL6 IL2 CXCL8
9
Show member pathways
12.56 TNF LTA IL6 IL2
10
Show member pathways
12.21 TNF IL6 CXCL8
11
Show member pathways
12.21 TNF IL6 IL2
12
Show member pathways
12.19 TNF IL6 CXCL8
13 12.18 TNF IL6 CXCL8
14
Show member pathways
12.15 TNF IL6 CXCL8
15 12.15 TNF LTA IL6 IL2
16 12.12 TNF IL6 CXCL8
17
Show member pathways
12.11 TNF IL6 CXCL8
18
Show member pathways
12.1 TNF IL6 IL2
19
Show member pathways
12.07 TNF IL6 CXCL8
20 12.06 TNF IL6 CXCL8
21
Show member pathways
11.94 TNF IL6 C1S
22 11.89 TNF IL6 IL2
23 11.88 TNF IL6 CXCL8
24 11.87 TNF LTA IL6
25
Show member pathways
11.86 TNF LTA IL6 IL2 CXCL8
26
Show member pathways
11.85 TNF LTA IL6 IL2
27 11.82 TNF LTA CXCL8
28 11.81 TNF IL6 CXCL8
29 11.8 TNF IL6 CXCL8
30 11.78 TNF IL6 IL2 CXCL8
31 11.76 TNF IL6 CXCL8
32 11.75 TNF IL6 IL2 CXCL8
33
Show member pathways
11.7 LTA IL2 CXCL8
34 11.69 IL6 IL2 CXCL8
35 11.68 TNF LTA IL2
36
Show member pathways
11.65 TNF IL2 CXCL8
37 11.63 TNF IL6 IL2
38 11.6 TNF IL6 IL2
39 11.54 TNF IL6 CXCL8
40 11.49 TNF IL6 CXCL8
41 11.43 TNF IL6 IL2
42 11.41 TNF IL6 CXCL8
43 11.39 TNF IL6 CXCL8
44
Show member pathways
11.36 TNF LTA IL6 IL2 CXCL8
45 11.34 TNF IL6 CXCL8 C1S
46 11.29 TNF IL6
47 11.26 TNF IL6
48 11.25 IL6 CXCL8
49 11.22 TNF IL6
50 11.2 TNF IL6

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TNF LTA IL6 IL2 CXCL8 C1S
2 extracellular space GO:0005615 9.1 TNF LTA IL6 IL2 CXCL8 C1S

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.71 CXCL8 IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.67 CXCL8 IL2 IL6 TNF
3 defense response to Gram-positive bacterium GO:0050830 9.63 IL6 LTA TNF
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 IL2 IL6 TNF
5 positive regulation of JAK-STAT cascade GO:0046427 9.57 IL6 TNF
6 negative regulation of neurogenesis GO:0050768 9.56 IL6 TNF
7 positive regulation of chemokine production GO:0032722 9.55 IL6 TNF
8 embryonic digestive tract development GO:0048566 9.52 CXCL8 TNF
9 positive regulation of immunoglobulin secretion GO:0051024 9.51 IL2 IL6
10 humoral immune response GO:0006959 9.5 IL6 LTA TNF
11 positive regulation of neuroinflammatory response GO:0150078 9.49 IL6 TNF
12 negative regulation of lipid storage GO:0010888 9.48 IL6 TNF
13 positive regulation of interferon-gamma production GO:0032729 9.43 IL2 LTA TNF
14 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.4 LTA TNF
15 immune response GO:0006955 9.35 CXCL8 IL2 IL6 LTA TNF
16 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 LTA TNF
17 positive regulation of glial cell proliferation GO:0060252 8.8 IL6 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA IL6 IL2 CXCL8
2 tumor necrosis factor receptor binding GO:0005164 8.96 TNF LTA

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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