MCID: STR077
MIFTS: 38

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 59
Streptococcal Toxic Shock Syndrome 72
Streptococcal Tss 59

Characteristics:

Orphanet epidemiological data:

59
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 34 A48.3
UMLS via Orphanet 73 C0343532
Orphanet 59 ORPHA99918
UMLS 72 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to fasciitis and impetigo. An important gene associated with Streptococcal Toxic-Shock Syndrome is IL6 (Interleukin 6), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include neutrophil, lung and skin.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 fasciitis 31.1 TNF IL6 CXCL8
2 impetigo 31.1 MYOM2 IL6
3 pharyngitis 30.9 MYOM2 CXCL8
4 laryngitis 30.7 TNF IL6
5 peritonitis 30.7 TNF IL6 CXCL8
6 endometritis 30.6 TNF IL6
7 infective endocarditis 30.6 TNF IL6
8 vaginitis 30.5 IL6 CXCL8
9 pericarditis 30.4 TNF IL6
10 exanthem 30.4 TNF IL6 IL2
11 adult respiratory distress syndrome 30.3 TNF IL6 CXCL8
12 bacterial infectious disease 30.2 TNF IL6 CXCL8
13 endocarditis 29.9 TNF IL6 CXCL8
14 alcoholic hepatitis 29.9 TNF IL6 CXCL8
15 osteomyelitis 29.9 TNF IL6 CXCL8
16 pneumonia 29.9 TNF IL6 CXCL8
17 acute respiratory distress syndrome 29.7 TNF LTA IL6 CXCL8
18 arthritis 29.3 TNF LTA IL6 CXCL8
19 necrotizing fasciitis 29.3 MYOM2 LTA IL6 IL2 CXCL8
20 rheumatic fever 28.9 TNF MYOM2 IL6 IL2
21 noonan syndrome 1 28.8 TNF IL6 IL2 CXCL8
22 rheumatoid arthritis 28.7 TNF IL6 IL2 CXCL8
23 capillary leak syndrome 28.7 IL6 IL2 CXCL8 C1S
24 toxic shock syndrome 28.5 TNF MYOM2 LTA IL6 IL2 CXCL8
25 systemic lupus erythematosus 28.3 TNF LTA IL6 IL2 C1S
26 disseminated intravascular coagulation 10.6
27 chickenpox 10.6
28 myelitis 10.5 TNF IL6
29 spondyloarthropathy 10.5 TNF IL6
30 streptococcal group a invasive disease 10.5
31 scorpion envenomation 10.5 TNF IL6
32 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
33 autoimmune myocarditis 10.5 TNF IL6
34 limb ischemia 10.5 TNF IL6
35 cardiogenic shock 10.5 TNF IL6
36 juvenile ankylosing spondylitis 10.5 TNF IL6
37 retinitis pigmentosa 55 10.5 TNF IL6
38 myositis 10.5
39 glossitis 10.5 TNF IL6
40 posterior urethral valves 10.4 TNF IL6
41 acute vascular insufficiency of intestine 10.4 TNF IL6
42 periapical periodontitis 10.4 TNF IL6
43 stachybotrys chartarum 10.4 TNF IL6
44 central nervous system vasculitis 10.4 TNF IL6
45 listeriosis 10.4 TNF IL6
46 autoimmune disease of eyes, ear, nose and throat 10.4 TNF IL6
47 transient hypogammaglobulinemia 10.4 TNF LTA
48 eales disease 10.4 TNF IL6
49 hypersensitivity reaction type iii disease 10.4 TNF IL6
50 mycoplasma pneumoniae pneumonia 10.4 TNF IL6

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Drugs for Streptococcal Toxic-Shock Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
2 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
3 Epidemiological Surveillance in India of Group A Streptococcal Infections Including Pharyngitis and Impetigo Supported by Indo-US Vaccine Action Program Completed NCT00342199
4 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
5 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Leon, Nicaragua Terminated NCT00170521

Search NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

41
Neutrophil, Lung, Skin, Heart, T Cells, Breast, Colon

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 618)
# Title Authors PMID Year
1
Associations between common respiratory viruses and invasive group A streptococcal infection: A time-series analysis. 38
31237087 2019
2
Prevalence of emm1 Streptococcus pyogenes having a novel type of genomic composition. 38
31403217 2019
3
Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUs. 38
31335381 2019
4
Complete Genome Sequence of emm1 Streptococcus pyogenes 10-85, a Strain Isolated from a Patient with Streptococcal Toxic Shock Syndrome in Japan. 38
31196924 2019
5
Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. 38
30744988 2019
6
Periorbital necrotising fasciitis secondary to scratching. 38
30733068 2019
7
Another Fatality Due to Postpartum Group A Streptococcal Endometritis in the Modern Era. 38
31312545 2019
8
Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro. 38
30996209 2019
9
Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 38
31151810 2019
10
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. 38
30981616 2019
11
Human polyspecific immunoglobulin attenuates group A streptococcal virulence factor activity and reduces disease severity in a murine necrotizing fasciitis model. 38
30025835 2019
12
Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects. 38
30977463 2019
13
Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes. 38
30698306 2019
14
Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF. 38
30837977 2019
15
Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System. 38
30881983 2019
16
A Patient of Using Presepsin to Diagnose Streptococcal Toxic Shock Syndrome during Anticancer Drug Treatment. 38
31139474 2019
17
Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus. 38
30691408 2019
18
Heterogeneity in FoxP3- and GARP/LAP-Expressing T Regulatory Cells in an HLA Class II Transgenic Murine Model of Necrotizing Soft Tissue Infections by Group A Streptococcus. 38
30224551 2018
19
Epidemiology and Clinical Relevance of Toxic Shock Syndrome in US Children. 38
29601458 2018
20
Streptococcus pyogenes bacteremia and toxic shock syndrome related to Strongyloides stercoralis hyperinfection: a case report. 38
30463627 2018
21
Characteristics of Intracranial Group A Streptococcal Infections in US Children, 1997-2014. 38
30462264 2018
22
Streptococcal toxic shock syndrome in a returning traveller. 38
30369302 2018
23
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. 38
29788397 2018
24
Epidemiology of an upsurge of invasive group A streptococcal infections in Ireland, 2012-2015. 38
29935196 2018
25
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. 38
30170621 2018
26
Fasciitis and Streptococcal Toxic-shock Syndrome: The Importance of Early Diagnosis and Surgical Management. 38
30740378 2018
27
Streptococcal toxic shock syndrome in the intensive care unit. 38
30225523 2018
28
[Streptococcal toxic shock syndrome caused by Streptococcus pyogenes: a retrospective study of 15 pediatric cases]. 38
30078239 2018
29
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. 38
28426384 2018
30
[Investigation of Streptococcus pyogenes virulence factors and typing by multiple locus variable number tandem repeat fingerprinting (MLVF) method]. 38
30156510 2018
31
Fulminant group A streptococcal infection without gangrene in the extremities: Analysis of five autopsy cases. 38
29722472 2018
32
Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome. 38
30085250 2018
33
A case report of hemolytic streptococcal gangrene in the danger triangle of the face with thrombocytopenia and hepatitis. 38
29933752 2018
34
Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3β and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection. 38
29581121 2018
35
Invasive disease by Streptococcus pyogenes: patients hospitalized for 6 years. 38
28705427 2018
36
Fulminant streptococcal toxic shock syndrome. 38
29741523 2018
37
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. 38
29107650 2018
38
Pathogenicity Induced by Invasive Infection of Streptococcus dysgalactiae subsp. equisimilis in a Mouse Model of Diabetes. 38
30298057 2018
39
Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein. 38
28973822 2018
40
An aggressive and fatal craniofacial group A Streptococcus infection resulting from a minimally displaced orbital floor fracture. 38
28803736 2018
41
Streptococcal toxic shock syndrome with primary group A streptococcus peritonitis in a healthy female. 38
30356961 2018
42
Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis. 38
30510834 2018
43
Streptococcal toxic shock syndrome - a life-threatening condition caused by various streptococcal species. 38
30126285 2018
44
Similarities and Differences Between Staphylococcal and Streptococcal Toxic Shock Syndromes in Children: Results From a 30-Case Cohort. 38
30547021 2018
45
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. 38
29254479 2017
46
Emerging group C and group G streptococcal endocarditis: A Canadian perspective. 38
29097247 2017
47
Treatment with antibodies against primary group A streptococcal peritonitis: A case report and a review of the literature. 38
29384948 2017
48
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. 38
28762570 2017
49
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. 38
28954758 2017
50
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp. equisimilis Infection in a Hemodialysis Patient. 38
29457020 2017

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TNF LTA IL6 IL2 CXCL8 C1S
2
Show member pathways
13.47 TNF LTA IL6 IL2 CXCL8
3
Show member pathways
13.34 TNF LTA IL6 IL2 CXCL8
4
Show member pathways
13.22 TNF LTA IL6 IL2 CXCL8
5
Show member pathways
13.17 TNF LTA IL6 IL2 CXCL8
6
Show member pathways
13.11 TNF LTA IL6 IL2 CXCL8
7
Show member pathways
12.93 TNF IL6 IL2 CXCL8
8
Show member pathways
12.63 TNF LTA IL6 IL2
9
Show member pathways
12.62 TNF LTA IL6 IL2 CXCL8
10
Show member pathways
12.55 TNF LTA IL6 IL2
11
Show member pathways
12.44 TNF IL6 IL2
12
Show member pathways
12.44 TNF IL6 IL2
13
Show member pathways
12.43 TNF IL6 IL2
14
Show member pathways
12.21 TNF IL6 IL2
15
Show member pathways
12.2 TNF IL6 CXCL8
16
Show member pathways
12.18 TNF IL6 CXCL8
17 12.18 TNF LTA IL6 IL2
18
Show member pathways
12.14 TNF IL6 CXCL8
19
Show member pathways
12.1 TNF IL6 CXCL8
20
Show member pathways
12.09 TNF IL6 IL2
21
Show member pathways
12.06 TNF IL6 CXCL8
22 12.05 TNF IL6 CXCL8
23
Show member pathways
11.94 TNF IL6 C1S
24 11.89 TNF IL6 IL2
25 11.88 TNF IL6 CXCL8
26 11.86 TNF LTA IL6
27
Show member pathways
11.86 TNF LTA IL6 IL2 CXCL8
28
Show member pathways
11.82 TNF LTA IL6 IL2
29 11.81 TNF IL6 CXCL8
30 11.8 TNF IL6 CXCL8
31 11.8 TNF LTA CXCL8
32 11.76 TNF IL6 CXCL8
33 11.75 TNF IL6 IL2 CXCL8
34
Show member pathways
11.7 LTA IL2 CXCL8
35 11.69 IL6 IL2 CXCL8
36 11.67 TNF LTA IL2
37
Show member pathways
11.64 TNF IL2 CXCL8
38 11.62 TNF IL6 IL2
39 11.59 TNF IL6 IL2
40 11.53 TNF IL6 CXCL8
41 11.47 TNF LTA
42 11.47 TNF IL6 CXCL8
43 11.44 IL6 CXCL8
44
Show member pathways
11.43 TNF LTA
45 11.41 TNF IL6 IL2
46 11.4 TNF IL2
47 11.4 TNF IL6
48 11.39 IL6 CXCL8
49 11.38 TNF IL6 CXCL8
50 11.37 TNF IL6

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TNF LTA IL6 IL2 CXCL8 C1S
2 extracellular space GO:0005615 9.1 TNF LTA IL6 IL2 CXCL8 C1S

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.75 TNF LTA IL6
2 cellular response to lipopolysaccharide GO:0071222 9.7 TNF IL6 CXCL8
3 cytokine-mediated signaling pathway GO:0019221 9.67 TNF IL6 IL2 CXCL8
4 defense response to Gram-positive bacterium GO:0050830 9.63 TNF LTA IL6
5 negative regulation of fat cell differentiation GO:0045599 9.57 TNF IL6
6 negative regulation of neurogenesis GO:0050768 9.56 TNF IL6
7 positive regulation of chemokine production GO:0032722 9.55 TNF IL6
8 embryonic digestive tract development GO:0048566 9.54 TNF CXCL8
9 negative regulation of growth of symbiont in host GO:0044130 9.51 TNF LTA
10 humoral immune response GO:0006959 9.5 TNF LTA IL6
11 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL6 IL2
12 negative regulation of lipid storage GO:0010888 9.48 TNF IL6
13 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6
14 positive regulation of interferon-gamma production GO:0032729 9.43 TNF LTA IL2
15 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.4 TNF LTA
16 immune response GO:0006955 9.35 TNF LTA IL6 IL2 CXCL8
17 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.16 TNF LTA
18 positive regulation of glial cell proliferation GO:0060252 8.8 TNF LTA IL6

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TNF LTA IL6 IL2 CXCL8
2 tumor necrosis factor receptor binding GO:0005164 8.96 TNF LTA

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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