MCID: STR077
MIFTS: 38

Streptococcal Toxic-Shock Syndrome

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Streptococcal Toxic-Shock Syndrome

MalaCards integrated aliases for Streptococcal Toxic-Shock Syndrome:

Name: Streptococcal Toxic-Shock Syndrome 60
Streptococcal Toxic Shock Syndrome 74
Streptococcal Tss 60

Characteristics:

Orphanet epidemiological data:

60
streptococcal toxic-shock syndrome
Inheritance: Not applicable; Prevalence: 1-9/1000000 (France),1-9/1000000 (United States),1-9/1000000 (Sweden),1-9/1000000 (Denmark);

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

ICD10 via Orphanet 35 A48.3
UMLS via Orphanet 75 C0343532
Orphanet 60 ORPHA99918
UMLS 74 C0343532

Summaries for Streptococcal Toxic-Shock Syndrome

MalaCards based summary : Streptococcal Toxic-Shock Syndrome, also known as streptococcal toxic shock syndrome, is related to fasciitis and infective endocarditis. An important gene associated with Streptococcal Toxic-Shock Syndrome is LTA (Lymphotoxin Alpha), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include eye, monocytes and heart.

Related Diseases for Streptococcal Toxic-Shock Syndrome

Diseases related to Streptococcal Toxic-Shock Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 303)
# Related Disease Score Top Affiliating Genes
1 fasciitis 30.8 CXCL8 IL6 TNF
2 infective endocarditis 30.5 IL6 TNF
3 pericarditis 30.5 IL6 TNF
4 peritonitis 30.4 CXCL8 IL6 TNF
5 pharyngitis 30.2 CXCL8 MYOM2
6 impetigo 30.2 IL6 MYOM2
7 arthritis 30.1 CXCL8 IL6 LTA TNF
8 vaginitis 30.0 CXCL8 IL6
9 endocarditis 29.9 CXCL8 IL6 TNF
10 toxic shock syndrome 29.7 C1S CXCL8 IL2 IL6 LTA MYOM2
11 necrotizing fasciitis 29.7 CXCL8 IL2 IL6 LTA MYOM2
12 rheumatoid arthritis 29.5 CXCL8 IL2 IL6 TNF
13 noonan syndrome 1 29.2 CXCL8 IL2 IL6 TNF
14 staphylococcal toxic shock syndrome 11.6
15 chickenpox 10.4
16 yellow fever 10.3 IL6 LTA
17 optic neuritis 10.3 LTA TNF
18 apnea, obstructive sleep 10.3 IL6 TNF
19 temporal arteritis 10.3 IL6 TNF
20 melioidosis 10.3 IL6 TNF
21 joint disorders 10.3 IL6 TNF
22 chikungunya 10.3 IL6 TNF
23 dengue shock syndrome 10.3 IL6 TNF
24 autoimmune disease of eyes, ear, nose and throat 10.3 IL6 TNF
25 ileitis 10.3 IL6 TNF
26 endometritis 10.3 IL6 TNF
27 dry eye syndrome 10.3 IL6 TNF
28 q fever 10.3 IL6 TNF
29 protein-energy malnutrition 10.3 IL6 TNF
30 crimean-congo hemorrhagic fever 10.3 IL6 TNF
31 keratoconjunctivitis sicca 10.3 IL6 TNF
32 plasmodium vivax malaria 10.3 IL6 TNF
33 periventricular leukomalacia 10.3 IL6 TNF
34 mycoplasma pneumoniae pneumonia 10.3 IL6 TNF
35 adult-onset still's disease 10.3 IL6 TNF
36 lacrimal apparatus disease 10.3 IL6 TNF
37 echinococcosis 10.3 IL6 TNF
38 hypersensitivity reaction type iii disease 10.3 IL6 TNF
39 spinal cord disease 10.3 IL6 TNF
40 complex regional pain syndrome 10.3 IL6 TNF
41 uveal disease 10.3 IL6 TNF
42 mixed connective tissue disease 10.3 IL6 TNF
43 extrinsic cardiomyopathy 10.3 IL6 TNF
44 localized scleroderma 10.3 IL6 TNF
45 rosacea 10.3 IL6 TNF
46 lymph node disease 10.3 IL6 TNF
47 eales disease 10.3 IL6 TNF
48 idiopathic neutropenia 10.3 IL6 TNF
49 rasmussen encephalitis 10.3 IL6 TNF
50 stromal keratitis 10.3 IL6 TNF

Graphical network of the top 20 diseases related to Streptococcal Toxic-Shock Syndrome:



Diseases related to Streptococcal Toxic-Shock Syndrome

Symptoms & Phenotypes for Streptococcal Toxic-Shock Syndrome

Drugs & Therapeutics for Streptococcal Toxic-Shock Syndrome

Search Clinical Trials , NIH Clinical Center for Streptococcal Toxic-Shock Syndrome

Genetic Tests for Streptococcal Toxic-Shock Syndrome

Anatomical Context for Streptococcal Toxic-Shock Syndrome

MalaCards organs/tissues related to Streptococcal Toxic-Shock Syndrome:

42
Eye, Monocytes, Heart, Spinal Cord, T Cells, Skin, Colon

Publications for Streptococcal Toxic-Shock Syndrome

Articles related to Streptococcal Toxic-Shock Syndrome:

(show top 50) (show all 203)
# Title Authors Year
1
Streptococcal toxic shock syndrome caused by β-hemolytic streptococci: Clinical features and cytokine and chemokine analyses of 15 cases. ( 30744988 )
2019
2
Streptococcal Toxic Shock Syndrome After Insertion of a Levonorgestrel Intrauterine Device. ( 30981616 )
2019
3
Fasciitis and Streptococcal Toxic-shock Syndrome: The Importance of Early Diagnosis and Surgical Management. ( 30740378 )
2018
4
Successful Treatment of Streptococcal Toxic Shock Syndrome with Both Diffuse Peritonitis and Necrotizing Fasciitis. ( 30510834 )
2018
5
Streptococcal toxic shock syndrome with primary group A streptococcus peritonitis in a healthy female. ( 30356961 )
2018
6
A 2-year-old boy with circulatory failure owing to streptococcal toxic shock syndrome: case report. ( 28426384 )
2018
7
Molecular characterization and antibiotic resistance of Streptococcus dysgalactiae subspecies equisimilis isolated from patients with streptococcal toxic shock syndrome. ( 29107650 )
2018
8
Fulminant streptococcal toxic shock syndrome. ( 29741523 )
2018
9
Polyspecific Intravenous Immunoglobulin in Clindamycin-treated Patients With Streptococcal Toxic Shock Syndrome: A Systematic Review and Meta-analysis. ( 29788397 )
2018
10
Streptococcal toxic shock syndrome - a life-threatening condition caused by various streptococcal species. ( 30126285 )
2018
11
Successful treatment of out-of-hospital cardiopulmonary arrest due to streptococcal toxic shock syndrome - effectiveness of extracorporeal membrane oxygenation and the rapid antigen group A streptococcus test: a case report. ( 30170621 )
2018
12
Streptococcal toxic shock syndrome in the intensive care unit. ( 30225523 )
2018
13
Streptococcal toxic shock syndrome in a returning traveller. ( 30369302 )
2018
14
Infective Endocarditis Associated with Streptococcal Toxic Shock Syndrome due to Streptococcus dysgalactiae subsp. equisimilis Infection in a Hemodialysis Patient. ( 29457020 )
2017
15
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
16
Rare presentation of necrotising fasciitis and streptococcal toxic shock syndrome by group A streptococcus. ( 28954758 )
2017
17
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
18
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
19
Pleural empyema and streptococcal toxic shock syndrome due to Streptococcus pyogenes in a healthy Spanish traveler in Japan. ( 28725562 )
2017
20
Group B Streptococcal Toxic Shock Syndrome and covR/S Mutations Revisited. ( 27983484 )
2017
21
Streptococcal Toxic Shock Syndrome Caused by Group G Streptococcus, United Kingdom. ( 27983491 )
2017
22
Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. ( 28698738 )
2017
23
Streptococcal toxic shock syndrome occurring in the third trimester of pregnancy: A case report. ( 28762570 )
2017
24
Streptococcal toxic shock syndrome caused by the dissemination of an invasive emm3/ST15 strain of Streptococcus pyogenes. ( 29254479 )
2017
25
Right in Front of Our Eyes: Evolution of Streptococcal Toxic Shock Syndrome with Ischemic Optic Neuropathy. ( 27903001 )
2016
26
Group A streptococcal toxic shock syndrome secondary to necrotizing pelvic inflammatory disease in a postmenopausal woman. ( 27419069 )
2016
27
Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK. ( 26861052 )
2016
28
Intrauterine device infection causing concomitant streptococcal toxic shock syndrome and pelvic abscess with Actinomyces odontolyticus bacteraemia. ( 26965406 )
2016
29
Profuse watery diarrhoea: An unusual presenting feature of streptococcal toxic shock syndrome. ( 27124845 )
2016
30
Spontaneous mutations in Streptococcus pyogenes isolates from streptococcal toxic shock syndrome patients play roles in virulence. ( 27349341 )
2016
31
Recurrent SDSE bacteraemia resulting in streptococcal toxic shock syndrome in a patient with Noonan syndrome. ( 27485878 )
2016
32
A fatal case of streptococcal toxic shock syndrome caused by Streptococcus suis carrying tet (40) and tet (O/W/32/O), Italy. ( 27553071 )
2016
33
Streptococcal Toxic Shock Syndrome: Life Saving Role of Peritoneal Lavage and Drainage. ( 27579001 )
2016
34
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2015
35
Cases of death due to serious group A streptococcal toxic shock syndrome in pregnant females in Japan. ( 25194311 )
2015
36
Efficacy of polyspecific intravenous immunoglobulin therapy in streptococcal toxic shock syndrome. ( 25313253 )
2015
37
Streptococcal toxic shock syndrome complicating a peritonsillar abscess. ( 25342572 )
2015
38
Increased prevalence of group A streptococcus isolates in streptococcal toxic shock syndrome cases in Japan from 2010 to 2012. ( 25703404 )
2015
39
Role of intravenous immune globulin in streptococcal toxic shock syndrome and Clostridium difficile infection. ( 26025992 )
2015
40
Streptococcal toxic shock syndrome secondary to group A Streptococcus vaginitis. ( 26386777 )
2015
41
Management of primary iliopsoas abscess in an immunocompetent patient followed by streptococcal toxic shock syndrome: A case report. ( 27489682 )
2015
42
Necrotizing fasciitis and streptococcal toxic shock syndrome secondary to varicella in a healthy child. ( 25653688 )
2014
43
Phlegmonous gastritis associated with group A streptococcal toxic shock syndrome. ( 25400190 )
2014
44
Treatment of postoperative purulent pericarditis and streptococcal toxic shock syndrome by intensive blood purification. ( 25228196 )
2014
45
Case of streptococcal toxic shock syndrome caused by rapidly progressive group A hemolytic streptococcal infection during postoperative chemotherapy for cervical cancer. ( 23937219 )
2014
46
Streptococcal Toxic Shock syndrome. ( 24297338 )
2014
47
Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient. ( 24464696 )
2014
48
Streptococcal toxic shock syndrome following total thyroidectomy. ( 24780814 )
2014
49
Clinical efficacy of polyspecific intravenous immunoglobulin therapy in patients with streptococcal toxic shock syndrome: a comparative observational study. ( 24928291 )
2014
50
A fatal case of streptococcal toxic shock syndrome due to Streptococcus dysgalactiae subsp. equisimilis possibly caused by an intramuscular injection. ( 23370754 )
2013

Variations for Streptococcal Toxic-Shock Syndrome

Expression for Streptococcal Toxic-Shock Syndrome

Search GEO for disease gene expression data for Streptococcal Toxic-Shock Syndrome.

Pathways for Streptococcal Toxic-Shock Syndrome

Pathways related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 C1S CXCL8 IL2 IL6 LTA TNF
2
Show member pathways
13.47 CXCL8 IL2 IL6 LTA TNF
3
Show member pathways
13.34 CXCL8 IL2 IL6 LTA TNF
4
Show member pathways
13.22 CXCL8 IL2 IL6 LTA TNF
5
Show member pathways
13.17 CXCL8 IL2 IL6 LTA TNF
6
Show member pathways
13.11 CXCL8 IL2 IL6 LTA TNF
7
Show member pathways
12.93 CXCL8 IL2 IL6 TNF
8
Show member pathways
12.63 IL2 IL6 LTA TNF
9
Show member pathways
12.61 CXCL8 IL2 IL6 LTA TNF
10
Show member pathways
12.55 IL2 IL6 LTA TNF
11
Show member pathways
12.44 IL2 IL6 TNF
12
Show member pathways
12.44 IL2 IL6 TNF
13
Show member pathways
12.42 IL2 IL6 TNF
14
Show member pathways
12.21 IL2 IL6 TNF
15
Show member pathways
12.2 CXCL8 IL6 TNF
16
Show member pathways
12.18 CXCL8 IL6 TNF
17 12.18 IL2 IL6 LTA TNF
18
Show member pathways
12.14 CXCL8 IL6 TNF
19
Show member pathways
12.1 CXCL8 IL6 TNF
20
Show member pathways
12.09 IL2 IL6 TNF
21
Show member pathways
12.06 CXCL8 IL6 TNF
22 12.05 CXCL8 IL6 TNF
23
Show member pathways
11.94 C1S IL6 TNF
24 11.89 IL2 IL6 TNF
25 11.88 CXCL8 IL6 TNF
26 11.86 IL6 LTA TNF
27
Show member pathways
11.86 CXCL8 IL2 IL6 LTA TNF
28
Show member pathways
11.82 IL2 IL6 LTA TNF
29 11.8 CXCL8 IL6 TNF
30 11.79 CXCL8 LTA TNF
31 11.78 CXCL8 IL6 TNF
32 11.75 CXCL8 IL6 TNF
33 11.75 CXCL8 IL2 IL6 TNF
34
Show member pathways
11.7 CXCL8 IL2 LTA
35 11.69 CXCL8 IL2 IL6
36 11.67 IL2 LTA TNF
37
Show member pathways
11.64 CXCL8 IL2 TNF
38 11.62 IL2 IL6 TNF
39 11.59 IL2 IL6 TNF
40 11.53 CXCL8 IL6 TNF
41 11.47 LTA TNF
42 11.46 CXCL8 IL6 TNF
43 11.44 CXCL8 IL6
44
Show member pathways
11.43 LTA TNF
45 11.41 IL2 IL6 TNF
46 11.4 IL6 TNF
47 11.4 IL2 TNF
48 11.39 CXCL8 IL6
49 11.38 CXCL8 IL6 TNF
50 11.37 IL6 TNF

GO Terms for Streptococcal Toxic-Shock Syndrome

Cellular components related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 C1S CXCL8 IL2 IL6 LTA TNF
2 extracellular space GO:0005615 9.1 C1S CXCL8 IL2 IL6 LTA TNF

Biological processes related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.76 IL6 LTA TNF
2 cellular response to lipopolysaccharide GO:0071222 9.71 CXCL8 IL6 TNF
3 cytokine-mediated signaling pathway GO:0019221 9.71 CXCL8 IL2 IL6 TNF
4 defense response to Gram-positive bacterium GO:0050830 9.65 IL6 LTA TNF
5 negative regulation of fat cell differentiation GO:0045599 9.58 IL6 TNF
6 negative regulation of neurogenesis GO:0050768 9.57 IL6 TNF
7 positive regulation of chemokine production GO:0032722 9.56 IL6 TNF
8 embryonic digestive tract development GO:0048566 9.55 CXCL8 TNF
9 immune response GO:0006955 9.55 CXCL8 IL2 IL6 LTA TNF
10 humoral immune response GO:0006959 9.54 IL6 LTA TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.52 LTA TNF
12 positive regulation of immunoglobulin secretion GO:0051024 9.51 IL2 IL6
13 positive regulation of interferon-gamma production GO:0032729 9.5 IL2 LTA TNF
14 negative regulation of lipid storage GO:0010888 9.49 IL6 TNF
15 positive regulation of neuroinflammatory response GO:0150078 9.46 IL6 TNF
16 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.43 LTA TNF
17 regulation of signaling receptor activity GO:0010469 9.35 CXCL8 IL2 IL6 LTA TNF
18 positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 9.26 LTA TNF
19 positive regulation of glial cell proliferation GO:0060252 8.8 IL6 LTA TNF

Molecular functions related to Streptococcal Toxic-Shock Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CXCL8 IL2 IL6 LTA TNF
2 tumor necrosis factor receptor binding GO:0005164 8.96 LTA TNF

Sources for Streptococcal Toxic-Shock Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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