MCID: STR103
MIFTS: 47

Streptococcus Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Streptococcus Pneumonia

Summaries for Streptococcus Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Streptococcus pneumoniae.

MalaCards based summary : Streptococcus Pneumonia is related to pneumonia and haemophilus influenzae. An important gene associated with Streptococcus Pneumonia is TRAF6 (TNF Receptor Associated Factor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and lung, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 73 Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic... more...

Related Diseases for Streptococcus Pneumonia

Diseases related to Streptococcus Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 831)
# Related Disease Score Top Affiliating Genes
1 pneumonia 30.6 TNF TLR4 TLR2 IL6 IL1B IL17A
2 haemophilus influenzae 30.5 TNF TLR2 CXCL8
3 pleural empyema 30.4 IL6 CRP CD4
4 vasculitis 30.1 TNF IL6 IL17A CRP
5 disseminated intravascular coagulation 30.1 TNF IL6 IL10 CRP
6 adult respiratory distress syndrome 29.9 TNF IL6 IL1B IL10 CXCL8
7 common variable immunodeficiency 29.8 TNF TLR9 TLR2 IL6 IL1B IL10
8 endocarditis 29.8 TNF TLR2 IL6 IL17A IL10 CXCL8
9 aortitis 29.8 TNF IL6 IL1B IL17A CRP CD4
10 neutropenia 29.8 TNF IL6 IL1B IL10 CXCL8 CRP
11 aortic aneurysm, familial abdominal, 1 29.8 TNF IL6 IL1B IL10 CXCL8 CRP
12 conjunctivitis 29.7 TNF TLR4 NLRP3 IL6 IL10 CXCL8
13 bronchitis 29.7 TNF TLR4 TLR2 IL6 IL1B IL10
14 candidiasis 29.5 TNF TLR4 TLR2 IL6 IL1B IL17A
15 toxic shock syndrome 29.5 TNF TLR4 TLR2 IL6 IL1B IL10
16 peritonitis 29.5 TNF TLR4 TLR2 NLRP3 IL6 IL1B
17 bacterial meningitis 29.4 TNF TLR9 TLR4 TLR2 IL6 IL1B
18 meningitis 29.3 TNF TLR9 TLR4 TLR2 NLRP3 IL6
19 respiratory failure 29.3 TNF TLR4 IL6 IL1B IL10 CXCL8
20 chlamydia 29.3 TNF TLR4 TLR2 IL6 IL1B IL17A
21 osteomyelitis 29.2 TNF TLR4 TLR2 NLRP3 IL6 IL1B
22 otitis media 29.1 TNF TLR4 TLR2 SFTPA2 SFTPA1 IL6
23 bacterial pneumonia 29.1 TNF TLR4 TLR2 IL6 IL1B IL17A
24 chlamydia pneumonia 29.1 TNF TLR4 TLR2 IL6 IL1B IL10
25 bronchopneumonia 29.0 TNF TLR4 IL6 IL1B IL17A IL10
26 bacterial infectious disease 28.9 TNF TLR9 TLR4 TLR2 IL6 IL1B
27 pulmonary disease, chronic obstructive 28.8 TNF TLR2 SIGLEC5 IL6 IL1B IL17A
28 immune deficiency disease 28.6 TNF TLR9 TLR2 SIGLEC5 IL6 IL1B
29 disease by infectious agent 28.4 TNF TLR9 TLR4 TLR2 SIGLEC5 IL6
30 lung disease 28.3 TNF TLR9 TLR4 TLR2 SFTPA2 SFTPA1
31 external pathological resorption 10.5 TNF IL6
32 scorpion envenomation 10.4 TNF IL6
33 punctate inner choroidopathy 10.4 TNF IL10
34 mycobacterium chelonae 10.4 TLR2 CXCL8
35 tropical endomyocardial fibrosis 10.4 TNF IL10
36 mycobacterium marinum 10.4 TLR2 CXCL8
37 staphylococcal toxic shock syndrome 10.4 TNF IL1B
38 anaerobic pneumonia 10.4 TLR2 IL6 IL1B
39 physiological polycythemia 10.4 TNF IL6 IL1B
40 periodontitis, chronic 10.4 IL6 IL1B
41 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
42 anti-basement membrane glomerulonephritis 10.4 CFHR2 CD4 CCR6
43 drug reaction with eosinophilia and systemic symptoms 10.4 TNF CRP
44 multifocal choroiditis 10.4 TNF IL10
45 ulcer of lower limbs 10.4 TNF IL6 IL1B
46 stachybotrys chartarum 10.4 TNF IL6 IL1B
47 spotted fever rickettsiosis 10.4 TNF IL10
48 carbuncle 10.4 TNF IL6 IL1B
49 cardiogenic shock 10.4 TNF IL6
50 kashin-beck disease 10.4 TNF IL1B

Graphical network of the top 20 diseases related to Streptococcus Pneumonia:



Diseases related to Streptococcus Pneumonia

Symptoms & Phenotypes for Streptococcus Pneumonia

MGI Mouse Phenotypes related to Streptococcus Pneumonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CCR6 CD4 CD8A CYLD IL10 IL17A
2 homeostasis/metabolism MP:0005376 10.28 CCR6 CD4 CRP CYLD IL10 IL17A
3 immune system MP:0005387 10.27 CCR6 CD4 CD8A CRP CYLD IL10
4 digestive/alimentary MP:0005381 10.2 CD4 CYLD IL10 IL17A IL6 NLRP3
5 integument MP:0010771 10.1 CD4 CD8A CYLD IL10 IL17A IL1B
6 mortality/aging MP:0010768 10.1 CD4 CD8A CYLD IL10 IL17A IL1B
7 neoplasm MP:0002006 9.7 CYLD IL10 IL1B IL6 TLR2 TLR4
8 renal/urinary system MP:0005367 9.56 CD8A IL17A IL6 NLRP3 TLR2 TLR4
9 respiratory system MP:0005388 9.23 CYLD IL10 IL17A IL6 SFTPA1 TLR2

Drugs & Therapeutics for Streptococcus Pneumonia

Drugs for Streptococcus Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4 83905-01-5 55185 447043
2
Levoleucovorin Approved, Investigational Phase 4 68538-85-2 149436
3
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
4
Sulfamethoxazole Approved Phase 4 723-46-6 5329
5
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
6
Telithromycin Approved Phase 4 191114-48-4 5462516 70789201
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
8 Immunologic Factors Phase 4
9 Vaccines Phase 4
10 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
11 penicillins Phase 4
12 Anti-Bacterial Agents Phase 4
13 Anti-Infective Agents Phase 4
14 Folic Acid Antagonists Phase 4
15 Vitamin B9 Phase 4
16 Antiparasitic Agents Phase 4
17 Folate Phase 4
18 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
19 Vitamin B Complex Phase 4
20 Antimalarials Phase 4
21 Antiprotozoal Agents Phase 4
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 cefuroxime axetil Phase 4
24
Linezolid Approved, Investigational Phase 3 165800-03-3 441401
25 Immunoglobulins Phase 3
26 Immunoglobulin E Phase 3
27 Immunoglobulins, Intravenous Phase 3
28 Antibodies Phase 3
29 Antibiotics, Antitubercular Phase 3
30 Aluminum phosphate Phase 3
31 Adjuvants, Immunologic Phase 3
32 Broncho-Vaxom Phase 3
33
Aluminum hydroxide Approved, Investigational Phase 1, Phase 2 21645-51-2
34
BCG vaccine Approved, Investigational Phase 2
35
Aluminum sulfate Approved Phase 1, Phase 2 10043-01-3
36
Vancomycin Approved Phase 1 1404-90-6 441141 14969
37
Tetracycline Approved, Vet_approved Phase 1 60-54-8 5353990
38 methicillin Phase 1
39 Pharmaceutical Solutions Phase 1
40
Ciprofloxacin Approved, Investigational 85721-33-1 2764
41
Ofloxacin Approved 82419-36-1 4583
42
Moxifloxacin Approved, Investigational 151096-09-2, 354812-41-2 152946
43
Levofloxacin Approved, Investigational 100986-85-4 149096
44
Erythromycin Approved, Investigational, Vet_approved 114-07-8 12560
45
tannic acid Approved 1401-55-4
46
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
47 Anti-Retroviral Agents
48 Cephalosporins
49 Erythromycin Estolate
50 Erythromycin Ethylsuccinate

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 1-Year Longitudinal Follow-up Study of Serologic Responses to 7-valent Pneumococcal Conjugated Vaccination and Opsonophagocytic Activities for Streptococcus Pneumoniae Among Patients With Human Immunodeficiency Virus Infection Unknown status NCT00885625 Phase 4
2 A Randomised Controlled Trial Comparing Two-Dose Priming With the 10-Valent Pneumococcal Conjugate Vaccine at 6 and 10 Weeks to 6 and 14 Weeks in Nepali Children Completed NCT02385513 Phase 4
3 An Evaluation of the Impact of Cotrimoxazole Prophylaxis for HIV-Infected Adults on the Development of Antifolate Resistance Among Plasmodium Falciparum, Streptococcus Pneumoniae, and Escherichia Coli Completed NCT00137657 Phase 4 Cotrimoxazole (trimethoprim sulfamethoxazole)
4 Response to Pneumococcal Vaccination in Patients After Community Acquired Pneumonia With Streptococcus Pneumoniae Compared to Pneumonia Patients With Another Pathogen. Completed NCT02141009 Phase 4
5 Streptococcus Pneumoniae Colonization and Immunogenicity of 13-valent Conjugate Pneumococcal Vaccine in Patients 50 Years or Older With End Stage Renal Disease on Dialysis. Completed NCT01974817 Phase 4
6 An Open-label, Randomized, Multicenter, Clinical Study to Compare the Effects of Telithromycin, Azithromycin and Cefuroxime Axetil on the Penicillin or Macrolide Resistance of Streptococcus Pneumoniae in Patients With Acute Exacerbation of Chronic Bronchitis Completed NCT00132938 Phase 4 telithromycin
7 The Effect Of Polivalent Mechanical Bacterial Lysate On The Clinical Course Of Grass Pollen-Induced Allergic Rhinitis In Children Completed NCT04270552 Phase 3 Ismigen;Placebo
8 A Phase 3b, Randomized, Open-Label, Multi-Center Study to Evaluate the Safety and Immunogenicity of 2 or 3 Doses of MenACWY Conjugate Vaccine in Healthy Infants and the Effects of a Booster Dose of MenACWY Administered in the Second Year of Life. Completed NCT01214837 Phase 3
9 The Effect of Polyvalent Mechanical Bacterial Lysate on the Reduction of Nasal Staphylococcus Aureus Carriage in Children With Pollen Allergic Rhinitis Completed NCT04637425 Phase 3 Ismigen;Placebo
10 Multicentre, Randomised, Double Blind, Placebo-controlled Study of the Efficacy and Safety of Broncho-Vaxom (OM 85 BV) in Children Suffering From Atopic Dermatitis Completed NCT03047954 Phase 3 Broncho-Vaxom;Placebo - Cap
11 An Alternative Booster Vaccine Against Meningitis and Ear Infections. Completed NCT01443416 Phase 3
12 Immunogenicity and Safety Study of the 13-valent Pneumococcal Polysaccharide Conjugate Vaccine Developed Cooperatively by YunNan Walvax Biotechnology Co., Lt and Yuxi Walvax Biotechnology Co., Lt Among 2-71 Months (the Youngest Could be 6 Weeks) Healthy Infants and Toddlers by Randomized Blind Method With Similar Control in Multi-centers. Completed NCT02736240 Phase 3
13 Immunogenicity and Safety of a Booster Dose of Polysaccharide Pneumococcal Vaccine (Pneumo 23®) in 12 to 18 Months-Old Children Primed With Three Doses of Pneumococcal Conjugate Vaccine (Prevnar®) in Thailand. Completed NCT00594347 Phase 3
14 Effect of 2 Versus 3 Pneumococcal Conjugate Vaccinations Prevnar on Nasopharyngeal Carriage, Transmission and Herd-immunity;a Randomized, Controlled Study Completed NCT00189020 Phase 3
15 A Phase 3, Randomized, Active-Controlled, Double-blind Trial Evaluating the Impact of a 13-valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Colonization With Vaccine Serotypes of Streptococcus Pneumoniae in Healthy Infants in Israel. Completed NCT00508742 Phase 3
16 Serological Response to Antipneumococcal Vaccination and Consequent Impact on Streptococcus Pneumoniae Nasal Carriage in HIV Positive Adults: a Prospective Study Using 13-valent Conjugate Vaccine Completed NCT02123433 Phase 3
17 Linezolid in the Treatment of Penicillin-Resistant Streptococcus Pneumoniae Pneumonia: An Open-Label, Non-Comparator Study Completed NCT00035269 Phase 3 Antibiotic
18 The Effect of Immunostimulation With Polyvalent Mechanical Bacterial Lysate on Changes in the Concentration of iNKT Cells in Children With Allergic Rhinitis. Enrolling by invitation NCT04802616 Phase 3 Ismigen;Placebo
19 Impact of the 7 Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. Pneumoniae in Healthy Jordanian Infants. Unknown status NCT00900978 Phase 1, Phase 2
20 Phase 1-2 Safety and Immunogenicity Study of PATH-wSP in Kenyan Adults and Toddlers Completed NCT02543892 Phase 1, Phase 2
21 A Phase II Study Evaluating the Safety and Immunogenicity of a New TB Vaccine, MVA85A, in Healthy Children and Infants After BCG Vaccination at Birth Completed NCT00679159 Phase 2
22 A Dose-Finding Study to Assess the Safety, Tolerability, and Immunogenicity of Inactivated Streptococcus Pneumoniae Whole Cell Vaccine Formulated With Alum (PATH-wSP) in Healthy Kenyan Young Adults and PCV-Primed Toddlers Completed NCT02097472 Phase 1, Phase 2
23 Evaluation of a 9-valent CRM 197- Conjugated Pneumococcal Polysaccharide Vaccine in Elderly Adults Completed NCT00133549 Phase 2 Placebo
24 An Open, Phase II Study to Evaluate the Response Rate to the Licensed Single-Dose Polysaccharide Pneumococcal Vaccine Pneumovax 23™ (MSD Aventis Pasteur) in Elderly Population. Completed NCT00307008 Phase 2
25 Immunogenicity of a Reduced Primary Schedule for Pneumococcal Conjugate Vaccine in UK Infants Completed NCT00197769 Phase 2
26 Evaluation of the Immunogenicity and Reactogenicity of a Pneumococcal Conjugate Vaccine in Healthy Adults Completed NCT00197821 Phase 2
27 A Phase I-II, Randomized, Double-Blind, Study to Evaluate the Safety, Tolerability, and Immunogenicity of V114 in Healthy Adults and Infants Completed NCT02037984 Phase 1, Phase 2
28 A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects Completed NCT02135302 Phase 1 eravacycline
29 A Study to Evaluate GlaxoSmithKline (GSK) Biologicals' Investigational Vaccination Regimen in Healthy Young Adults Completed NCT00814489 Phase 1
30 A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Dose Escalation Study to Evaluate the Safety, Tolerability, and Immunogenicity of GEN-004, a Streptococcus Pneumoniae Protein Subunit Vaccine, in Adult Subjects Completed NCT01995617 Phase 1
31 A Phase 1 Randomized, Double-Blind, Dose-Escalation Study to Assess the Safety, Tolerability and Immunogenicity of Inactivated Streptococcus Pneumoniae Whole Cell Vaccine Formulated With Alum (SPWCV+Alum) in Healthy Adults Completed NCT01537185 Phase 1
32 An Open-Label Phase 1 Study Assessing the Safety, Immunogenicity and Dose Response of IC47, a New Vaccine Against Streptococcus Pneumoniae, in Healthy Subjects. Completed NCT00873431 Phase 1
33 Randomised, Multicentre, Double-blind, Placebo-controlled Study to Assess the Safety, Efficacy and Pharmacodynamics After the Intravenous Administration of CAL02 in Severe Community-acquired Pneumonia Due to Streptococcus Pneumoniae Completed NCT02583373 Phase 1 CAL02 Low-dose;CAL02 High-dose;Placebo
34 Comparative Phase I Safety and Immunogenicity in Adult Volunteers of Three Recombinant Attenuated Salmonella Typhi Vaccine Vectors Producing Streptococcus Pneumoniae Surface Protein Antigen PspA Completed NCT01033409 Phase 1
35 Safety and Immunogenicity of a Candidate Bioconjugate Vaccine Against Streptococcus Pneumoniae When Administered to Adult and Elderly Healthy Subjects. A Phase I Randomized Study. Completed NCT03303976 Phase 1
36 An Observer-blind, Safety Study of GSK Biologicals' Haemophilus Influenzae and Streptococcus Pneumoniae Candidate Vaccine in Adults. Terminated NCT00849069 Phase 1
37 Longitudinal Pattern of Streptococcus Pneumoniae Nasopharyngeal Carriage and Antimicrobial Susceptibility in Healthy Children Aged Less Then 5 Years, in the Area of Milan and Surroundings, Lombardy, Italy. Unknown status NCT01443793
38 Evaluation of Quantitative and Qualitative Antibody Responses to Streptococcus Pneumoniae and Haemophilus Influenzae Type b Conjugate Vaccines Amongst HIV-1-Exposed-Infected Children That Are Receiving Vs. Those Not Receiving Antiretroviral Therapy, as Well as Among HIV-1-Exposed-Uninfected Children and HIV-1-Unexposed-Uninfected Children Unknown status NCT00099658
39 Streptococcus Pneumoniae Nasopharyngeal Carriage Among Children Attending Day-care Centres in the Alpes Maritimes. Substudy: Enterobacterial Intestinal Carriage and Susceptibility to 3rd Generation Cephalosporins Unknown status NCT01485029
40 Global Active Surveillance for Community-Acquired Pneumonia (CAP) in Adults 50 Years and Older Completed NCT00929721
41 Immune Response to Pneumococcal Vaccination in Aging HIV Positive Individuals Completed NCT03039491 Early Phase 1
42 An Epidemiological Survey to Establish the Spectrum of Circulating Serotypes of S. Pneumoniae, in Patients Older 18 Years: Healthy Carriage, Patients With Non-invasive and Invasive Pneumococcal Infections in the Russian Federation Completed NCT04464291
43 Etiology of Community Acquired Pneumonia Completed NCT00471757
44 A Prospective Study to Evaluate the Immune Response of UK Infants Receiving the 13-valent Pneumococcal Conjugate Vaccine as Part of Their Routine Primary Immunisation Schedule at 2 and 4 Months Completed NCT01425372
45 Effects of Pneumococcal Vaccine on Nasopharyngeal Carriage: a FinIP Effectiveness Trial Satellite Study During PCV National Vaccination Programme Completed NCT01925222
46 Neisseria Meningitidis Burden of Disease Completed NCT01730391
47 Prevalence of Nasopharyngeal Carriage of Streptococcus Pneumoniae in Healthy Children Aged 12-18 Months in Six Cities of China Completed NCT00952367
48 Assessment of the Nasopharyngeal Carriage of Streptococcus Pneumoniae (Sp) and Other Common Pathogens in Infants (6-30 Months of Age) With Acute Otitis Media and in Healthy Infants (6-30 Months of Age) Attending Day-care Centers Completed NCT02888457
49 An Evaluation of Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Taiwanese Children Attending Pediatric Clinics in Hospitals, Day Care Centers, or Kindergartens Completed NCT00471822
50 Pharyngeal Carriage Rates and Genetic Typing of Group A Streptococcus and Streptococcus Pneumonia Among Israeli Military Basic Trainees Completed NCT00808821

Search NIH Clinical Center for Streptococcus Pneumonia

Genetic Tests for Streptococcus Pneumonia

Anatomical Context for Streptococcus Pneumonia

MalaCards organs/tissues related to Streptococcus Pneumonia:

40
Bone, Skin, Lung, Heart, Liver, Eye, Lymph Node

Publications for Streptococcus Pneumonia

Articles related to Streptococcus Pneumonia:

(show top 50) (show all 553)
# Title Authors PMID Year
1
Protective effects of Re-yan-ning mixture on Streptococcus pneumonia in rats based on network pharmacology. 61
33678123 2021
2
The human natural anti-αGal antibody targets common pathogens by broad-spectrum polyreactivity. 61
33340093 2021
3
Aetiology and antimicrobial susceptibility pattern of bacterial isolates in community acquired pneumonia patients at Asir region, Saudi Arabia. 61
33448574 2021
4
A Case Report of Acquired Factor X Deficiency in a Patient With Multiple Myeloma. 61
33728224 2021
5
Infectious keratitis: trends in microbiological and antibiotic sensitivity patterns. 61
33469134 2021
6
The microbiologic spectrum of dacryocystitis. 61
33430825 2021
7
Targeting protein tyrosine phosphatase to unravel possible inhibitors for Streptococcus pneumoniae using molecular docking, molecular dynamics simulations coupled with free energy calculations. 61
33164832 2021
8
Analysis of Pathogen Distribution and Its Antimicrobial Resistance in Bloodstream Infections in Hospitalized Children in East China, 2015-2018. 61
33367870 2021
9
[Anti-microbial activity of Rosmarinus officinalis and Zingiber officinale extracts on the species of the genus Candida and on Streptococcus pneumonia]. 61
32565159 2021
10
The identification of co-expressed gene modules in Streptococcus pneumonia from colonization to infection to predict novel potential virulence genes. 61
33334315 2020
11
Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children-A Population-Based Study From Norway. 61
33298760 2020
12
Biosynthesis of silver nanoparticles from marine diatoms Chaetoceros sp., Skeletonema sp., Thalassiosira sp., and their antibacterial study. 61
33312881 2020
13
Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018. 61
32530357 2020
14
Green synthesis, characterization, antimicrobial and cytotoxic effect of silver nanoparticles using arabinoxylan isolated from Kalmegh. 61
32599238 2020
15
Children discharged from an emergency department with bacteraemia had lower C-reactive protein and better outcomes than admissions. 61
33128310 2020
16
Pertussis-like syndrome often not associated with Bordetella pertussis: 5-year study in a large children's hospital. 61
32589094 2020
17
The importance of intracellular bacterial biofilm in infectious diseases. 61
32711113 2020
18
Isolated Native Tricuspid Valve Endocarditis in an HIV Patient due to Streptococcus Pneumoniae: A Rare Clinical Phenomenon. 61
33154848 2020
19
The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life. 61
32476604 2020
20
Structural insights into the formation of oligomeric state by a type I Hsp40 chaperone. 61
32621942 2020
21
Otitis media with effusion is not a sterile inflammatory process: scanning electron microscope evidence. 61
32889624 2020
22
Microbiological spectrum of microbial keratitis in patients presenting with nasolacrimal duct obstruction. 61
32615806 2020
23
Staphylococcus lentus Sinusitis: A New Sinonasal Pathogen. 61
31072191 2020
24
Co infection of respiratory syncytial viruses (RSV) and streptococcus pneumonia modulates pathogenesis and dependent of serotype and phase variant. 61
32173494 2020
25
Bioguided chemical study of Boswellia dalzielii Hutch. (Burseraceae) for antibacterial agents and a new glucopyranoxylmethoxybenzyle. 61
32729328 2020
26
Searching the staphylococcal toxic shock syndrome toxin -1 in septic children with negative cultures: A comparative study in Tehen,Iran. 61
32735530 2020
27
Severe Human Metapneumovirus and Group A Streptococcus Pneumonia in an Immunocompetent Adult. 61
31563939 2020
28
Loop-Primer Endonuclease Cleavage-Loop-Mediated Isothermal Amplification Technology for Multiplex Pathogen Detection and Single-Nucleotide Polymorphism Identification. 61
32409120 2020
29
Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia. 61
32460745 2020
30
Rhinovirus impairs the immune response of alveolar macrophages to facilitate Streptococcus pneumonia infection. 61
32358959 2020
31
Detection of nasal microbiota in pediatric patients with antrochoanal polyps by TLDA. 61
31837561 2020
32
An antifouling peptide-based biosensor for determination of Streptococcus pneumonia markers in human serum. 61
31999579 2020
33
Mathematical modeling of the 'inoculum effect': six applicable models and the MIC advancement point concept. 61
31960902 2020
34
Analysis Of Blood Culture Results Of Burn Septicaemia Patients Over A Period Of Nine Years In The Baghdad Burn Medical Centre. 61
32523492 2020
35
Update on protracted bacterial bronchitis in children. 61
32228653 2020
36
[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL]. 61
32186784 2020
37
GC-MS and GC-FID analyses of the volatile constituents of Brachychiton rupestris and Brachychiton discolor, their biological activities and their differentiation using multivariate data analysis. 61
30445846 2020
38
PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-κB activity. 61
31838134 2020
39
Design, Synthesis and In vitro Biological Activity of Some New 1,3- thiazolidine-4-one Derivatives as Chemotherapeutic Agents using Virtual Screening Strategies. 61
31951175 2020
40
Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children. 61
33306743 2020
41
Targeting Glycans on Human Pathogens for Vaccine Design. 61
30046985 2020
42
Considering Interim Interventions to Control COVID-19 Associated Morbidity and Mortality-Perspectives. 61
33072682 2020
43
Fine Particulate Matter Exposure Alters Pulmonary Microbiota Composition and Aggravates Pneumococcus-Induced Lung Pathogenesis. 61
33195201 2020
44
Deterministic epidemic model for ( SVCSyCAsyIR ) pneumonia dynamics, with vaccination and temporal immunity. 61
32154465 2020
45
Hypocrellin B-Mediated Photodynamic Inactivation of Gram-Positive Antibiotic-Resistant Bacteria: An In Vitro Study. 61
31634029 2020
46
The Pneumococcal Polysaccharide-Tetanus Toxin Native C-Fragment Conjugate Vaccine: The Carrier Effect and Immunogenicity. 61
32714092 2020
47
[Molecular epidemiology peculiarities in forming of antimicrobial resistance of Streptococcus pneumonia strains, isolated in elderly patients.] 61
33280331 2020
48
The Expression of NOX From Synthetic Promoters Reveals an Important Role of the Redox Status in Regulating Secondary Metabolism of Saccharopolyspora erythraea. 61
32766231 2020
49
A case of fulminant pneumococcus meningoencephalitis progressing with white matter involvement despite two doses of conjugated pneumococcus vaccine. 61
33372445 2020
50
Austrian syndrome: The deadly triad. 61
32923368 2020

Variations for Streptococcus Pneumonia

Expression for Streptococcus Pneumonia

Search GEO for disease gene expression data for Streptococcus Pneumonia.

Pathways for Streptococcus Pneumonia

Pathways related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 TRAF6 TNF TLR9 TLR4 TLR2 SIGLEC5
2
Show member pathways
13.87 TRAF6 TNF IL6 IL1B IL17A IL10
3
Show member pathways
13.74 TNF TLR4 IL6 IL1B IL17A IL10
4
Show member pathways
13.54 TRAF6 TNF TLR9 TLR4 TLR2 IL6
5
Show member pathways
13.45 TRAF6 TNF IL6 IL1B IL17A IL10
6
Show member pathways
13.4 TNF IL6 IL1B IL17A IL10 CXCL8
7
Show member pathways
13.31 TRAF6 TNF TLR9 TLR4 TLR2 SFTPA2
8
Show member pathways
13.08 TRAF6 TNF TLR4 TLR2 IL6 IL1B
9
Show member pathways
13.01 TNF IL6 IL1B IL17A IL10 CXCL8
10
Show member pathways
12.99 TRAF6 TNF TLR9 TLR4 TLR2 NLRP3
11 12.9 TRAF6 TNF TLR9 TLR2 IL6 IL1B
12
Show member pathways
12.89 TRAF6 TNF TLR9 TLR4 TLR2 IL1B
13
Show member pathways
12.89 TRAF6 TNF TLR9 TLR4 TLR2 NLRP3
14
Show member pathways
12.85 TRAF6 TNF TLR9 TLR4 TLR2 IL6
15
Show member pathways
12.78 TNF TLR4 TLR2 IL6 IL1B IL17A
16 12.73 TRAF6 TNF TLR9 TLR2 IL1B IL17A
17
Show member pathways
12.72 TRAF6 TNF IL1B IL10 CYLD
18
Show member pathways
12.72 TNF IL6 IL1B IL17A IL10 CD4
19
Show member pathways
12.72 TRAF6 TNF TLR9 TLR4 TLR2 IL1B
20
Show member pathways
12.6 TRAF6 TNF TLR9 TLR4 TLR2 IL6
21 12.56 TRAF6 TNF TLR4 NLRP3 IL1B CXCL8
22
Show member pathways
12.53 TRAF6 TNF TLR2 IL6 IL1B IL17A
23
Show member pathways
12.52 TRAF6 TNF TLR9 TLR4 TLR2 NLRP3
24
Show member pathways
12.47 TRAF6 TNF TLR4 IL6 IL1B CXCL8
25
Show member pathways
12.46 TRAF6 TNF TLR9 TLR4 TLR2 IL6
26
Show member pathways
12.45 TNF IL6 IL10 CXCL8 CCR6
27
Show member pathways
12.43 TRAF6 TNF TLR4 TLR2 IL1B IL10
28 12.42 TRAF6 TNF TLR4 NLRP3 IL6 IL1B
29
Show member pathways
12.4 TNF IL6 IL1B IL17A IL10 CXCL8
30
Show member pathways
12.4 TRAF6 TNF TLR2 IL6 IL1B CXCL8
31
Show member pathways
12.39 TNF TLR9 NLRP3 IL6 IL1B IL10
32
Show member pathways
12.38 TNF IL6 IL1B CRP
33 12.38 TRAF6 TNF TLR9 TLR4 TLR2 IL6
34
Show member pathways
12.34 TNF TLR4 NLRP3 IL1B CYLD
35 12.32 TNF TLR9 TLR4 TLR2 IL6
36 12.31 TNF IL6 IL1B IL10 CXCL8
37
Show member pathways
12.24 TRAF6 TNF TLR9 TLR4 TLR2 SFTPA1
38 12.22 TLR4 TLR2 SFTPA2 SFTPA1
39 12.19 TNF IL6 IL1B IL17A IL10 CXCL8
40 12.18 TNF TLR4 IL6 IL1B CXCL8
41 12.16 TNF IL6 IL10 CD8A CD4
42 12.14 TRAF6 TNF TLR4 IL1B CYLD CXCL8
43
Show member pathways
12.13 TLR9 TLR4 TLR2 IL1B
44 12.1 TNF TLR4 TLR2 IL6 IL1B IL10
45
Show member pathways
12.08 TRAF6 IL1B CD8A CD4
46 12.08 TNF IL6 IL1B CD8A CD4
47
Show member pathways
12.05 TRAF6 TLR4 IL6 IL17A CXCL8
48 12.02 TNF IL6 IL1B CXCL8
49 12.02 TNF TLR4 TLR2 IL6 IL1B IL17A
50
Show member pathways
12 TLR9 TLR4 TLR2 IL6 IL1B IL17A

GO Terms for Streptococcus Pneumonia

Cellular components related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 TNF SFTPA2 SFTPA1 IL6 IL1B IL17A
2 extracellular region GO:0005576 9.44 TNF TLR9 SFTPA2 SFTPA1 NLRP3 IL6
3 external side of plasma membrane GO:0009897 9.43 TNF TLR4 IL17A CD8A CD4 CCR6
4 lamellar body GO:0042599 9.26 SFTPA2 SFTPA1

Biological processes related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.38 TRAF6 TLR9 TLR4 TLR2 NLRP3 IL6
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.29 TRAF6 TNF TLR9 TLR4 TLR2 NLRP3
3 innate immune response GO:0045087 10.22 TLR9 TLR4 TLR2 NLRP3 IL17A CYLD
4 immune system process GO:0002376 10.2 TRAF6 TLR9 TLR4 TLR2 NLRP3 IL17A
5 negative regulation of cell proliferation GO:0008285 10.14 TLR2 IL6 IL1B IL10 CXCL8
6 positive regulation of gene expression GO:0010628 10.14 TNF TLR9 TLR4 TLR2 IL6 IL1B
7 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.07 TRAF6 TNF TLR9 TLR4 CD4
8 cytokine-mediated signaling pathway GO:0019221 10.06 TRAF6 TNF IL6 IL1B IL17A IL10
9 response to lipopolysaccharide GO:0032496 10.03 TLR4 TLR2 IL1B IL10
10 positive regulation of DNA-binding transcription factor activity GO:0051091 10.03 TRAF6 TNF IL6 IL1B IL10
11 activation of MAPK activity GO:0000187 10.01 TRAF6 TNF TLR4 IL1B
12 defense response to Gram-positive bacterium GO:0050830 10.01 TNF TLR2 IL6 IL17A CRP
13 positive regulation of inflammatory response GO:0050729 9.99 TNF TLR9 TLR4 TLR2 IL1B
14 negative regulation of interleukin-6 production GO:0032715 9.98 TNF TLR9 TLR4 IL10
15 positive regulation of tumor necrosis factor production GO:0032760 9.98 TLR9 TLR4 TLR2 IL6 IL17A
16 defense response to Gram-negative bacterium GO:0050829 9.97 TLR9 TLR4 IL6 IL17A CD4
17 positive regulation of JNK cascade GO:0046330 9.97 TRAF6 TNF TLR9 TLR4 IL1B
18 positive regulation of interferon-gamma production GO:0032729 9.96 TNF TLR9 TLR4 IL1B
19 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.96 TRAF6 TNF TLR9 TLR4
20 positive regulation of T cell proliferation GO:0042102 9.96 TRAF6 IL6 IL1B CD4
21 regulation of insulin secretion GO:0050796 9.92 TNF IL6 IL1B
22 response to glucocorticoid GO:0051384 9.92 TNF IL6 IL10
23 positive regulation of interleukin-10 production GO:0032733 9.92 TLR9 TLR4 TLR2 IL6
24 positive regulation of interleukin-1 beta production GO:0032731 9.92 TNF TLR4 NLRP3 IL6 IL17A
25 cellular response to lipopolysaccharide GO:0071222 9.92 TRAF6 TNF TLR4 NLRP3 IL6 IL1B
26 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 TRAF6 TNF IL6
27 humoral immune response GO:0006959 9.91 TNF IL6 CCR6
28 lipopolysaccharide-mediated signaling pathway GO:0031663 9.91 TNF TLR4 TLR2 IL1B
29 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.91 TRAF6 TNF TLR9 TLR4 TLR2 IL1B
30 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF TLR4 IL1B
31 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.9 TRAF6 TLR9 TLR4 TLR2
32 positive regulation of interferon-beta production GO:0032728 9.89 TLR9 TLR4 TLR2
33 positive regulation of interleukin-12 production GO:0032735 9.89 TRAF6 TLR9 TLR4 TLR2 IL17A
34 positive regulation of JAK-STAT cascade GO:0046427 9.88 TNF IL6 IL10
35 positive regulation of JUN kinase activity GO:0043507 9.88 TRAF6 TNF TLR9
36 positive regulation of interleukin-2 production GO:0032743 9.88 TRAF6 IL1B CD4
37 positive regulation of chemokine production GO:0032722 9.88 TNF TLR9 TLR4 TLR2 IL6
38 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR9 TLR4 TLR2 IL6 IL1B
39 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.87 TRAF6 TNF IL1B
40 negative regulation of neurogenesis GO:0050768 9.87 TNF IL6 IL1B
41 positive regulation of osteoclast differentiation GO:0045672 9.87 TRAF6 TNF IL17A
42 positive regulation of immunoglobulin production GO:0002639 9.86 TLR9 IL6 IL10
43 positive regulation of glial cell proliferation GO:0060252 9.86 TNF IL6 IL1B
44 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.86 TNF TLR4 IL6 IL17A
45 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.86 TRAF6 TNF TLR9 TLR4 TLR2 NLRP3
46 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.85 TLR9 TLR4 TLR2
47 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.85 TNF IL1B IL10
48 toll-like receptor signaling pathway GO:0002224 9.85 TRAF6 TLR9 TLR4 TLR2 SFTPA2 SFTPA1
49 inflammatory response GO:0006954 9.85 TNF TLR9 TLR4 TLR2 NLRP3 IL6
50 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.84 TRAF6 TNF IL6

Molecular functions related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TRAF6 TNF TLR9 TLR4 TLR2 SIGLEC5
2 identical protein binding GO:0042802 9.86 TRAF6 TNF TLR4 TLR2 NLRP3 CRP
3 signaling receptor activity GO:0038023 9.62 TLR4 TLR2 CD4 CCR6
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR4 TLR2
5 cytokine activity GO:0005125 9.1 TNF IL6 IL1B IL17A IL10 CXCL8

Sources for Streptococcus Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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