MCID: STR103
MIFTS: 33

Streptococcus Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Streptococcus Pneumonia

Summaries for Streptococcus Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Streptococcus pneumoniae.

MalaCards based summary : Streptococcus Pneumonia is related to epiglottitis and irak4 deficiency. An important gene associated with Streptococcus Pneumonia is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Pertussis and Osteoclast differentiation. The drugs Mycophenolic acid and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and lung.

Related Diseases for Streptococcus Pneumonia

Diseases related to Streptococcus Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 epiglottitis 11.5
2 irak4 deficiency 11.3
3 myd88 deficiency 11.3
4 mycoplasma pneumoniae pneumonia 11.1
5 dacryocystitis 11.1
6 bacterial pneumonia 10.8
7 haemophilus influenzae 10.8
8 pneumonia 10.7
9 meningitis 10.7
10 otitis media 10.6
11 hemolytic-uremic syndrome 10.5
12 idiopathic severe pneumococcemia 10.3
13 purpura 10.3
14 influenza 10.3
15 purpura fulminans 10.3
16 pericarditis 10.3
17 conjunctivitis 10.3
18 bacterial meningitis 10.3
19 pleural empyema 10.3
20 fasciitis 10.3
21 necrotizing fasciitis 10.3
22 endocarditis 10.2
23 pneumococcal meningitis 10.2
24 meningoencephalitis 10.2
25 endophthalmitis 10.2
26 arthritis 10.2
27 lung abscess 10.1
28 trachoma 10.1
29 epidural abscess 10.1
30 aortitis 10.1
31 septic arthritis 10.1
32 sinusitis 10.1
33 osteomyelitis 10.1
34 systemic lupus erythematosus 10.1
35 tetralogy of fallot 10.1
36 pelvic inflammatory disease 10.1
37 legionnaires' disease 10.1
38 bronchitis 10.1
39 vasculitis 10.1
40 lupus erythematosus 10.1
41 myeloma, multiple 10.0
42 pulmonary disease, chronic obstructive 10.0
43 hepatitis 10.0
44 mastoiditis 10.0
45 parotitis 10.0
46 chlamydia 10.0
47 cellulitis 10.0
48 pyomyositis 10.0
49 viral infectious disease 10.0
50 sickle cell disease 10.0

Graphical network of the top 20 diseases related to Streptococcus Pneumonia:



Diseases related to Streptococcus Pneumonia

Symptoms & Phenotypes for Streptococcus Pneumonia

Drugs & Therapeutics for Streptococcus Pneumonia

Drugs for Streptococcus Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 309)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4,Phase 2 24280-93-1 446541
2
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
6
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
7 Strawberry Approved Phase 4,Phase 3
8
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 26787-78-0 33613
9
Zinc Approved, Investigational Phase 4,Phase 3,Not Applicable 7440-66-6
10
Zinc sulfate Approved, Investigational Phase 4,Not Applicable 7733-02-0
11
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
12
Adalimumab Approved Phase 4 331731-18-1 16219006
13
Infliximab Approved Phase 4 170277-31-3
14
Tetracycline Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 60-54-8 5353990
15
Ibuprofen Approved Phase 4 15687-27-1 3672
16
Acetaminophen Approved Phase 4,Phase 3 103-90-2 1983
17
Certolizumab pegol Approved Phase 4 428863-50-7
18
Methotrexate Approved Phase 4,Phase 3,Phase 2 59-05-2, 1959-05-2 126941
19
leucovorin Approved Phase 4,Phase 3,Phase 2 58-05-9 6006 143
20
belimumab Approved Phase 4,Phase 2 356547-88-1 5957 10451420
21
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
22
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
23
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
24
Telithromycin Approved Phase 4 191114-48-4 0 5462516
25
Cefuroxime Approved Phase 4 55268-75-2 5361202 5479529
26
Cefoxitin Approved Phase 4 35607-66-0 441199
27
Cefotaxime Approved Phase 4 63527-52-6 456256 5742673
28
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2 50-28-2 5757
29
Moxifloxacin Approved, Investigational Phase 4,Phase 2 354812-41-2, 151096-09-2 152946
30
Ethinyl Estradiol Approved Phase 4,Phase 2 57-63-6 5991
31
Polyestradiol phosphate Approved Phase 4,Phase 2 28014-46-2
32 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2 979-32-8
33
Norgestimate Approved, Investigational Phase 4,Phase 2 35189-28-7 6540478
34
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
35
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
36
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
37
Levofloxacin Approved, Investigational Phase 4,Phase 2,Phase 1 100986-85-4 149096
38
Ofloxacin Approved Phase 4,Phase 2,Phase 1 82419-36-1 4583
39
Lenalidomide Approved Phase 4,Phase 2 191732-72-6 216326
40
Ceftriaxone Approved Phase 4,Phase 3 73384-59-5 5479530 5361919
41
Ritonavir Approved, Investigational Phase 4,Not Applicable 155213-67-5 392622
42
Lopinavir Approved Phase 4,Not Applicable 192725-17-0 92727
43
Efavirenz Approved, Investigational Phase 4,Phase 3,Phase 2 154598-52-4 64139
44
Albendazole Approved, Vet_approved Phase 4 54965-21-8 2082
45
Bortezomib Approved, Investigational Phase 4,Phase 2 179324-69-7 387447 93860
46
Daratumumab Approved Phase 4 945721-28-8
47 Ixazomib Approved, Investigational Phase 4 1072833-77-2
48
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
49
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
50
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7

Interventional clinical trials:

(show top 50) (show all 793)
# Name Status NCT ID Phase Drugs
1 7-valent Pneumococcal Conjugated Vaccination Unknown status NCT00885625 Phase 4
2 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
3 Study on the Efficacy of Phenytoin in the Prophylaxis of Seizures of Patients With Pneumococcal Meningitis at Least 50 Yrs Old. Unknown status NCT01478035 Phase 4 Phenytoin;placebo
4 B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic Individuals Unknown status NCT01846923 Phase 4
5 PCV13 + Hepatitis A Vaccine for Adults Unknown status NCT01926860 Phase 4
6 Pneumonia Vaccine in Liver Transplant Recipients: a Booster Strategy Using a Conjugate Vaccine Unknown status NCT00152802 Phase 4
7 Testing if BCG (Bacille Calmette-Guérin) Vaccination Can Induce Innate Immune Training in Adult People Above 50 Years of Age in Guinea-Bissau Unknown status NCT02953327 Phase 4
8 Polysaccharide Antibody Response Study Unknown status NCT02429531 Phase 4
9 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
10 Pertussis (Tdap) Vaccination in Pregnancy Unknown status NCT01698346 Phase 4
11 Influence of BCG on TDaP-IPV Vaccination Unknown status NCT02771782 Phase 4
12 Study Response of 13-valent Conjugate Pneumococcal Vaccine in Patients With End Stage Renal Disease Completed NCT01974817 Phase 4
13 PCV10 Immunogenicity Study Nepal 2015 Completed NCT02385513 Phase 4
14 Targeting of Immune Response After Pneumococcal Vaccination Completed NCT01402245 Phase 4
15 Protection Against Pneumococcal Infection in Children With T1DM Completed NCT01939522 Phase 4
16 Impact and Cost of a Pharmacist Pneumococcal Vaccination Program With PNEUMOVAX® 23 at an Urban Senior Center Completed NCT01944462 Phase 4
17 Safety and Immunogenicity of Sequential Pneumococcal Immunization in Preschool Asthmatics Completed NCT00836641 Phase 4
18 The Immunogenicity of Simultaneous Administration of Quadrivalent Influenza Vaccine and 23-valent Pneumococcal Vaccine Completed NCT02592486 Phase 4
19 13 Valent Pneumococcal Conjugate Vaccine - Follow-on Study Completed NCT01095471 Phase 4
20 Study Evaluating the Effiacy of a 13-Valent Pneumococcal Conjugate Vaccine (13vPnC) in Adults Completed NCT00744263 Phase 4
21 A Study To Assess The Safety And Effectiveness Of Prevenar In Chinese Children Who Have Not Previously Received A Vaccine Against Pneumococcal Bacteria Completed NCT01193582 Phase 4
22 Community Acquired Pneumonia: Outcome, Quality of Life and Immune Status Completed NCT02141009 Phase 4
23 Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults Completed NCT02062281 Phase 4
24 Pneumococcal Vaccination for Splenectomised Thalassemia Major Patients in Indonesia Completed NCT03095326 Phase 4 Sucrose
25 Concomitant Administration of 13-valent Pneumococcal Conjugate Vaccine (13vPnC) With Influenza Vaccine in 23-valent Pneumococcal Polysaccharide (23vPS) Pre-vaccinated Adults. Completed NCT02124161 Phase 4
26 Humoral Determinants of Immunity to Pneumococcal Infection Completed NCT00304382 Phase 4
27 Study Evaluating a 13-valent Pneumococcal Conjugate Vaccine in Preterm Compared to Term Infants. Completed NCT01193335 Phase 4
28 A Study to Assess the Antibody Response of Healthy Chinese Children Who Have Been Vaccinated Previously With 4-doses of Prevenar (a Pneumococcal Vaccine) as Babies and Toddlers Completed NCT01298544 Phase 4
29 Study Comparing Prevenar® to Pneumo 23 in Reducing Carriage in Children Completed NCT00580684 Phase 4
30 Induction of Immunity Against Streptococcus Pneumoniae in Adults With Inflammatory Bowel Disease Completed NCT01908283 Phase 4
31 Efficacy Study of Pneumococcal Vaccination in Crohn's Disease Completed NCT01505855 Phase 4 23-valent polysaccharide pneumococcal vaccine
32 Effectiveness of the Pneumococcal Polysaccharide Vaccine in Military Recruits Completed NCT02079701 Phase 4
33 The Effect of Live Attenuated Inactivated Influenza Vaccine on Experimental Human Pneumococcal Carriage Study Completed NCT03502291 Phase 4
34 Study Evaluating Prevenar Immunogenicity in High Risk Children Completed NCT00581620 Phase 4
35 Influenza Vaccine and Pneumococcal Vaccine Completed NCT02582047 Phase 4
36 PPSV23 Pneumococcal Vaccine in Chronic Obstructive Pulmonary Disease (COPD) Completed NCT01381367 Phase 4 Normal Saline
37 Study to Evaluate the Immune Response to Pneumococcal Vaccine in Alefacept-treated Adults With Chronic Plaque Psoriasis Completed NCT00493324 Phase 4 alefacept;polyvalent pneumococcal vaccine
38 Study of Evaluation Indexes for Antibody Production in Sera After Immunization Completed NCT00964769 Phase 4
39 Immunogenicity and Reactogenicity of PCV13 Among Infants and Children in Burkina Faso Completed NCT01577771 Phase 4
40 Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13® Completed NCT01392378 Phase 4 Paracetamol;Ibuprofen;Paracetamol;Ibuprofen
41 A Trial Evaluating a 7-valent Pneumococcal Conjugate Vaccine Given With Diphtheria, Tetanus, and Acellular Pertussis Vaccine (DTaP) in Healthy Japanese Infants. Completed NCT01250756 Phase 4
42 Response of United Kingdom (UK) Infants to a Reduced Primary Schedule With Meningococcal C and Pneumococcal Conjugate Vaccines Completed NCT00197808 Phase 4
43 Revaccination With PNEUMOVAX™ 23 in Older Japanese Adults (V110-902) Completed NCT02260882 Phase 4
44 Immunogenicity of 3+1 Versus 2+1 Schedule for PCV7 Completed NCT02040402 Phase 4
45 Immunogenicity of 7-Valent Pneumococcal Conjugate Vaccine in Lung Fluid of Adults With and Without HIV Infection Completed NCT00371878 Phase 4
46 MF59-adjuvanted Influenza Vaccine and 23-valent Pneumococcal Polysaccharide Vaccine Completed NCT02225327 Phase 4
47 13-valent Pneumococcal Conjugate Vaccine Study in Adults and Children in India Completed NCT02034877 Phase 4
48 Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment Completed NCT01235949 Phase 4 Ibuprofen;Paracetamol
49 Immunogenicity and Safety of a Tetanus-diphtheria Vaccine and a 13-valent Pneumococcal Conjugate Vaccine Completed NCT03552445 Phase 4
50 Immunogenicity and Safety of PCV13 and Fluad in Adults Aged ≥60 Years Completed NCT02215863 Phase 4

Search NIH Clinical Center for Streptococcus Pneumonia

Genetic Tests for Streptococcus Pneumonia

Anatomical Context for Streptococcus Pneumonia

MalaCards organs/tissues related to Streptococcus Pneumonia:

41
Colon, Testes, Lung, Neutrophil

Publications for Streptococcus Pneumonia

Articles related to Streptococcus Pneumonia:

(show all 39)
# Title Authors Year
1
Synthetic avenues towards a tetrasaccharide related to <i>Streptococcus pneumonia</i> of serotype 6A. ( 29977381 )
2018
2
Sacroiliitis and osteomyelitis caused by serotype 3 Streptococcus pneumonia in a previously healthy adult: a case report. ( 30122960 )
2018
3
Insights into the antibacterial mechanism of PEGylated nano-bacitracin A against Streptococcus pneumonia: both penicillin-sensitive and penicillin-resistant strains. ( 30349251 )
2018
4
Selection of DNA aptamers to Streptococcus pneumonia and fabrication of graphene oxide based fluorescent assay. ( 29964028 )
2018
5
Molecular Characterization and Correlation with β-lactam Resistance of Streptococcus pneumonia Isolates in Hangzhou, China. ( 29866221 )
2018
6
Subtractive genome analysis for in silico identification and characterization of novel drug targets in Streptococcus pneumonia strain JJA. ( 29277475 )
2018
7
Prolonged extracorporeal membrane oxygenation for pediatric necrotizing pneumonia due to Streptococcus pneumonia and influenza H1N1 co-infection: how long should we wait for native lung recovery? ( 29404795 )
2018
8
Inhibition of Glycogen Synthase Kinase 3β Blocks Mesomesenchymal Transition and Attenuates Streptococcus pneumonia-Mediated Pleural Injury in Mice. ( 29073967 )
2017
9
Fatal infection in adults by pneumolysin & autolysin producing, non-vaccine serotype Streptococcus pneumonia. ( 27377510 )
2016
10
Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis. ( 25755670 )
2015
11
Molecular analysis of pbp2b in Streptococcus pneumonia isolated from clinical and normal flora samples. ( 25274412 )
2015
12
Structural and biochemical analyses of the Streptococcus pneumonia L,D-carboxypeptidase DacB. ( 25664738 )
2015
13
The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice. ( 25700108 )
2015
14
pspK gene prevalence and characterization of non-typable Streptococcus pneumonia isolates from Asian countries. ( 25750083 )
2015
15
Correction: Host glycan sugar-specific pathways in Streptococcus pneumonia: galactose as a key sugar in colonisation and infection. ( 25928559 )
2015
16
Cylindromatosis (CYLD) inhibits Streptococcus pneumonia-induced plasminogen activator inhibitor-1 expression via interacting with TRAF-6. ( 26056944 )
2015
17
Prevalence of Nasopharyngeal Carriage of Streptococcus pneumonia in Iran: A Meta-Analysis. ( 26411658 )
2015
18
Nasopharyngeal carriage of Streptococcus pneumonia in pneumonia-prone age groups in Semarang, Java Island, Indonesia. ( 24498104 )
2014
19
Attributable healthcare utilization and cost of pneumonia due to drug-resistant streptococcus pneumonia: a cost analysis. ( 24851182 )
2014
20
Frequency of Streptococcus pneumonia and Haemophilus influenza in acute exacerbation of chronic obstructive airway disease and their sensitivity to levofloxacin. ( 24864632 )
2014
21
Streptococcus pneumonia. ( 25412638 )
2014
22
Catalytic mechanism of hyaluronate lyase from Streptococcus pneumonia [corrected] : quantum mechanical/molecular mechanical and density functional theory studies. ( 23944739 )
2013
23
Serotype distribution and antibiotics susceptibility pattern of Streptococcus pneumonia in Iran. ( 24693373 )
2013
24
Endovascular repair of a Streptococcus pneumonia-induced aortitis complicated by an iliacocaval fistula. ( 22956511 )
2012
25
Report on invasive disease and meningitis due to Haemophilus influenzae and Streptococcus pneumonia from the Network for Surveillance of Pneumococcal Disease in the East African Region. ( 19191610 )
2009
26
Safety and efficacy of vaccination against streptococcus pneumonia in patients with rheumatic diseases. ( 17412304 )
2007
27
Streptococcus pneumonia endocarditis associated with gastrointestinal malignancy. ( 17523295 )
2007
28
In-vitro susceptibility and molecular characterisation of macrolide resistance mechanisms among Streptococcus pneumonia isolates in The Netherlands: the DUEL 2 study. ( 15760429 )
2005
29
Serum concentrations of pneumococcal anticapsular antibodies in children with pneumonia associated with Streptococcus pneumonia infection. ( 14557973 )
2003
30
Streptococcus pneumonia YlxR at 1.35 A shows a putative new fold. ( 11679764 )
2001
31
Ceftriaxone treatment failure of meningitis due to penicillin and ceftriaxone resistant streptococcus pneumonia. ( 27704130 )
1998
32
Roentgenographic findings of pneumonia caused by Chlamydia pneumoniae. A comparison with streptococcus pneumonia. ( 8790080 )
1996
33
A household cluster of fulminant group A streptococcus pneumonia associated with toxic shock syndrome-Quebec. ( 8935389 )
1996
34
Analysis of the gene encoding type 12 PspA of Streptococcus pneumonia EF5668. ( 8586190 )
1995
35
Optochin sensitivity is encoded by the atpC gene of the Streptococcus pneumonia atp (F0F1 H(+)-ATPase) operon. ( 8586191 )
1995
36
Fatal Streptococcus pneumonia infection due to hyposplenism. ( 7992772 )
1994
37
Interruption of capsule production in Streptococcus pneumonia serotype 3 by insertion of transposon Tn916. ( 2167295 )
1990
38
Spontaneous streptococcus pneumonia peritonitis in a patient with metastatic gastric cancer: a case report and etiologic consideration. ( 870172 )
1977
39
SERUM TREATMENT OF HEMOLYTIC STREPTOCOCCUS PNEUMONIA. ( 16694172 )
1933

Variations for Streptococcus Pneumonia

Expression for Streptococcus Pneumonia

Search GEO for disease gene expression data for Streptococcus Pneumonia.

Pathways for Streptococcus Pneumonia

GO Terms for Streptococcus Pneumonia

Biological processes related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hydrogen peroxide GO:0070301 8.96 CBX8 MAPK13
2 nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 8.62 CYLD TRAF6

Sources for Streptococcus Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....