MCID: STR103
MIFTS: 47

Streptococcus Pneumonia

Categories: Infectious diseases, Respiratory diseases

Aliases & Classifications for Streptococcus Pneumonia

Summaries for Streptococcus Pneumonia

Disease Ontology : 12 A bacterial pneumonia has material basis in Streptococcus pneumoniae.

MalaCards based summary : Streptococcus Pneumonia is related to myd88 deficiency and irak4 deficiency. An important gene associated with Streptococcus Pneumonia is TRAF6 (TNF Receptor Associated Factor 6), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. The drugs Ceftaroline fosamil and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and lung, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 Streptococcus pneumoniae, or pneumococcus, is a Gram-positive, spherical bacteria, alpha-hemolytic... more...

Related Diseases for Streptococcus Pneumonia

Diseases related to Streptococcus Pneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 921)
# Related Disease Score Top Affiliating Genes
1 myd88 deficiency 33.0 TLR6 TLR5 TLR4 TLR2 TLR1
2 irak4 deficiency 32.6 TLR6 TLR5 TLR4 TLR2 TLR1
3 haemophilus influenzae 32.5 TNF TLR2 CXCL8
4 bacterial meningitis 32.1 TNF TLR9 TLR4 TLR2 IL6 IL1B
5 fasciitis 31.3 TNF IL6 CXCL8
6 necrotizing fasciitis 31.3 IL6 IL1B CXCL8
7 purpura 31.2 TNF IL6 IL10
8 tetanus 31.1 TNF IL6 IL1B IL10
9 conjunctivitis 31.1 TNF TLR3 IL6 IL10 CXCL8
10 meningitis 31.1 TNF TLR9 TLR4 TLR2 IL6 IL1B
11 lung abscess 31.1 TNF IL6 IL1B CD4
12 cholera 31.0 TNF IL6 IL1B CXCL8
13 pericarditis 31.0 TNF IL6 IL1B CXCL8 CD4
14 vasculitis 30.9 TNF IL6 IL17A IL10
15 bronchitis 30.9 TNF TLR4 TLR2 IL6 IL1B IL10
16 toxic shock syndrome 30.9 TNF TLR4 TLR2 IL6 IL1B IL10
17 endophthalmitis 30.9 TNF TLR2 IL6 IL1B CXCL8 CD4
18 trachoma 30.8 TNF IL6 IL17A IL10
19 meningococcal meningitis 30.8 TLR9 TLR4 TLR2
20 suppurative otitis media 30.8 TLR5 TLR4 TLR2 IL1B
21 graft-versus-host disease 30.8 TNF IL6 IL1B IL10
22 disseminated intravascular coagulation 30.8 TNF IL6 IL10
23 bronchiectasis 30.8 TNF TLR2 IL1B CXCL8
24 pneumonia 30.8 TNF TLR9 TLR6 TLR5 TLR4 TLR3
25 bacterial conjunctivitis 30.8 SIGLEC5 IL1B CXCL8
26 endocarditis 30.7 TNF TLR6 TLR2 IL6 IL17A IL10
27 prosthetic joint infection 30.7 TLR4 TLR2 IL6 IL1B
28 osteomyelitis 30.7 TNF TLR4 TLR2 IL6 IL1B IL10
29 pleurisy 30.7 TNF TLR4 TLR2 CXCL8
30 cellulitis 30.7 TNF IL6 IL1B IL17A IL10 CD4
31 infective endocarditis 30.6 TNF TLR6 TLR2 SIGLEC5 IL6 IL17A
32 peritonitis 30.6 TNF TLR4 TLR2 IL6 IL1B IL17A
33 chronic graft versus host disease 30.6 IL10 CD4
34 immune deficiency disease 30.6 TNF TLR9 TLR2 IL6 IL10 CD4
35 influenza 30.6 TNF TLR7 TLR4 TLR3 IL6 IL1B
36 acute disseminated encephalomyelitis 30.6 IL1B IL10 CCR6
37 aortitis 30.6 TNF IL6 IL1B IL17A CD4
38 neutropenia 30.6 TNF TLR4 IL6 IL1B IL10 CXCL8
39 pharyngitis 30.6 TNF IL6 IL1B CXCL8 CD4
40 legionnaire disease 30.5 TLR5 TLR4 TLR2
41 salpingitis 30.5 TNF TLR2 SIGLEC5 CD4
42 poliomyelitis 30.5 TNF IL10 CD4
43 pertussis 30.5 TNF TLR4 IL6 IL1B IL10 CXCL8
44 keratitis, hereditary 30.5 TNF TLR4 TLR2 IL6 IL1B IL17A
45 mixed connective tissue disease 30.5 TNF IL6 IL10
46 meningoencephalitis 30.5 TNF TLR3 IL6 IL1B IL10 CD4
47 acquired immunodeficiency syndrome 30.4 TNF IL6 IL1B IL10 CD4 CCR6
48 laryngitis 30.4 TNF IL6 IL1B
49 glossitis 30.4 TNF IL6 IL1B
50 obstructive jaundice 30.4 TNF TLR4 IL6 CXCL8

Graphical network of the top 20 diseases related to Streptococcus Pneumonia:



Diseases related to Streptococcus Pneumonia

Symptoms & Phenotypes for Streptococcus Pneumonia

MGI Mouse Phenotypes related to Streptococcus Pneumonia:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.39 CCR6 CD4 CYLD IL10 IL17A IL1B
2 immune system MP:0005387 10.32 CCR6 CD4 CYLD IL10 IL17A IL1B
3 homeostasis/metabolism MP:0005376 10.31 CCR6 CD4 CYLD IL10 IL17A IL1B
4 digestive/alimentary MP:0005381 10.22 CD4 CYLD IL10 IL17A IL6 TLR2
5 cardiovascular system MP:0005385 10.19 CCR6 IL10 IL1B IL6 TLR2 TLR3
6 endocrine/exocrine gland MP:0005379 10.16 CD4 CYLD IL10 IL17A IL6 TLR2
7 mortality/aging MP:0010768 10.1 CD4 CYLD IL10 IL17A IL1B IL6
8 integument MP:0010771 10.02 CD4 CYLD IL10 IL17A IL1B IL6
9 neoplasm MP:0002006 9.76 CYLD IL10 IL1B IL6 TLR2 TLR3
10 renal/urinary system MP:0005367 9.56 IL17A IL6 TLR2 TLR4 TLR7 TLR8
11 respiratory system MP:0005388 9.28 CYLD IL10 IL17A IL6 TLR2 TLR3

Drugs & Therapeutics for Streptococcus Pneumonia

Drugs for Streptococcus Pneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftaroline fosamil Approved, Investigational Phase 4 229016-73-3
2 Vaccines Phase 4
3 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
4 Immunologic Factors Phase 4
5 Immunoglobulins Phase 4
6 Antibodies Phase 4
7 Anti-Bacterial Agents Phase 4
8 Anti-Infective Agents Phase 4
9
Amoxicillin Approved, Vet_approved Phase 3 26787-78-0 33613
10
Azithromycin Approved Phase 3 83905-01-5 447043 55185
11 Antibiotics, Antitubercular Phase 3
12 Aluminum phosphate Phase 2
13
Clotrimazole Approved, Vet_approved 23593-75-1 2812
14
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
15
Chitosan Experimental 9012-76-4 71853
16 Pharmaceutical Solutions
17 Antifungal Agents
18 Mitogens

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Immunogenicity of Pneumococcal Vaccination and Revaccination in Older Adults Completed NCT00239694 Phase 4
2 Comparison of the Immunogenicity of the 3+1 Schedule and the 2+1 Schedule of 7-valent Pneumococcal Conjugated Vaccine in Young Chinese Infants Completed NCT02040402 Phase 4
3 Ceftaroline Pharmacokinetics in Critically Ill Patients Receiving Continuous Renal Replacement Therapy Recruiting NCT04152694 Phase 4
4 To Assess Safety, Reactogenicity and Immunogenicity of GSK Biologicals' 10-valent Pneumococcal Conjugate Vaccine, When Co-administered With DTPa-combined Vaccines and MenC or Hib-MenC Vaccines During the First 6 Months of Age. Completed NCT00334334 Phase 3
5 To Assess the Safety, Reactogenicity & Immunogenicity of a 4th Dose of GSK Biologicals' Pneumococcal Vaccine or Prevenar™ in Children (12-18 Months) Previously Vaccinated in the Primary Study NCT00307554 With Either Pneumococcal Vaccine or Prevenar™ Completed NCT00370396 Phase 3
6 To Assess Safety, Reactogenicity & Immunogenicity of a Booster Dose of Pneumococcal Conjugate Vaccine, Co-admin With GSK Biologicals' MMRV Vaccine in Children (2nd yr of Life) Primed With the Pneumococcal Conjugate Vaccine in Study 105553. Completed NCT00370227 Phase 3
7 Randomised Controlled Clinical Trial Investigating Benefits of Using Response to Broad Spectrum Antibiotics as an Exclusion Diagnostic for Tuberculosis (TB) in Primary Care Adult Patients Versus Risk of Antimicrobial Resistance (AMR) Recruiting NCT03545373 Phase 3 Azithromycin;Amoxicillin
8 Impact of the 7 Valent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of S. Pneumoniae in Healthy Jordanian Infants. Unknown status NCT00900978 Phase 1, Phase 2
9 A Multicenter, Double-Blind Study of the Safety, Tolerability, and Immunogenicity of a Pneumococcal Conjugate Vaccine (V114) Compared to Pneumococcal Polysaccharide Vaccine (PNEUMOVAX® 23) and PREVNAR 13® (Pneumococcal 13-Valent Conjugate Vaccine [Diphtheria CRM197 Protein]) in Healthy Adults 50 Years of Age or Older Completed NCT01513551 Phase 2
10 Oral and Tracheal Cultures in Pediatric ICU Patients Compared to Healthy Children Unknown status NCT03418272
11 Comparison of Nasal Saline Irrigation Bottle Contamination Between Two Solutions Unknown status NCT02413125 Normal saline
12 Assessment of the Nasopharyngeal Carriage of Streptococcus Pneumoniae (Sp) and Other Common Pathogens in Infants (6-30 Months of Age) With Acute Otitis Media and in Healthy Infants (6-30 Months of Age) Attending Day-care Centers Unknown status NCT02888457
13 Community Acquired Bacteremic Syndromes in Young Nigerian Children Unknown status NCT02946775
14 Pharyngeal Carriage Rates and Genetic Typing of Group A Streptococcus and Streptococcus Pneumonia Among Israeli Military Basic Trainees Completed NCT00808821
15 Streptococcus Pneumonia: Herd Effects and Emergence of Potentially Virulent Serotypes PCV13_Impact of NP Colonization, Herd Effects and Emergence of Potentially Virulent Serotypes of Pneumococci Completed NCT01109108
16 Prospective System Analysis of Seasonal Influenza - Virus Transmission and Evolution in Basle Town Completed NCT03451656
17 Etiology of Community Acquired Pneumonia Completed NCT00471757
18 An Incitative Multifaceted PROcedure for Pneumococcal Vaccination at the Emergency Department; A Multicenter Prospective Randomized Open Trial The IMPROVED Project Completed NCT01899365
19 Prospective Analysis of Seasonal Influenza - Viral Transmission and Evolution in the City of Basel, Switzerland [Prospektive Systemanalyse Der Saisonalen Influenza - Virustransmission Und Evolution in Der Stadt Basel] in German Completed NCT03010007
20 Rapid Test for Detection of the Focus of Infection in Post Neurosurgical Patients. Recruiting NCT03252028

Search NIH Clinical Center for Streptococcus Pneumonia

Genetic Tests for Streptococcus Pneumonia

Anatomical Context for Streptococcus Pneumonia

MalaCards organs/tissues related to Streptococcus Pneumonia:

40
Colon, Testes, Lung, Neutrophil, Brain, Skin, T Cells

Publications for Streptococcus Pneumonia

Articles related to Streptococcus Pneumonia:

(show top 50) (show all 525)
# Title Authors PMID Year
1
Co infection of respiratory syncytial viruses (RSV) and streptococcus pneumonia modulates pathogenesis and dependent of serotype and phase variant. 61
32173494 2020
2
Staphylococcus lentus Sinusitis: A New Sinonasal Pathogen. 61
31072191 2020
3
Airway bacterial carriage and childhood respiratory health: a population-based prospective cohort study. 61
32524657 2020
4
Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018. 61
32530357 2020
5
Severe Human Metapneumovirus and Group A Streptococcus Pneumonia in an Immunocompetent Adult. 61
31563939 2020
6
[Antimicrobial activity of Rosmarinus officinalis and Zingiber officinale extracts on the species of the genus Candida and on Streptococcus pneumonia.] 61
32565159 2020
7
Shen-ling-bai-zhu-san ameliorates inflammation and lung injury by increasing the gut microbiota in the murine model of Streptococcus pneumonia-induced pneumonia. 61
32460745 2020
8
Loop-Primer Endonuclease Cleavage-Loop-Mediated Isothermal Amplification Technology for Multiplex Pathogen Detection and Single-Nucleotide Polymorphism Identification. 61
32409120 2020
9
The large family of PC4-like domains - similar folds and functions throughout all kingdoms of life. 61
32476604 2020
10
Rhinovirus impairs the immune response of alveolar macrophages to facilitate Streptococcus pneumonia infection. 61
32358959 2020
11
An antifouling peptide-based biosensor for determination of Streptococcus pneumonia markers in human serum. 61
31999579 2020
12
Update on protracted bacterial bronchitis in children. 61
32228653 2020
13
[MORAXELLA OSLOENSIS BACTEREMIA WITH PNEUMONIA: FIRST REPORTED CASE IN ISRAEL]. 61
32186784 2020
14
Mathematical modeling of the 'inoculum effect': six applicable models and the MIC advancement point concept. 61
31960902 2020
15
Analysis Of Blood Culture Results Of Burn Septicaemia Patients Over A Period Of Nine Years In The Baghdad Burn Medical Centre. 61
32523492 2020
16
Detection of nasal microbiota in pediatric patients with antrochoanal polyps by TLDA. 61
31837561 2020
17
GC-MS and GC-FID analyses of the volatile constituents of Brachychiton rupestris and Brachychiton discolor, their biological activities and their differentiation using multivariate data analysis. 61
30445846 2020
18
PHD2 exerts anti-cancer and anti-inflammatory effects in colon cancer xenografts mice via attenuating NF-κB activity. 61
31838134 2020
19
Design, Synthesis and In-Vitro Biological Activity of Some New 1,3-Thiazolidine-4-One Derivatives as Chemotherapeutic Agents Using Virtual Screening Strategies. 61
31951175 2020
20
Deterministic epidemic model for ( SVCSyCAsyIR ) pneumonia dynamics, with vaccination and temporal immunity. 61
32154465 2020
21
Hypocrellin B-Mediated Photodynamic Inactivation of Gram-Positive Antibiotic-Resistant Bacteria: An In Vitro Study. 61
31634029 2020
22
Acute suppurative thyroiditis with thyroid abscess in adults: clinical presentation, treatment and outcomes. 61
31791298 2019
23
External Quality Assessment of Bacterial Identification and Antimicrobial Susceptibility Testing in African National Public Health Laboratories, 2011-2016. 61
31847247 2019
24
Differential IL-17A response to S. pneumoniae in adenoid tissue of children with sleep disordered breathing and otitis media with effusion. 61
31882693 2019
25
[TREATMENT OF SECRETORY OTITIS MEDIA IN CHILDREN, DEPENDING ON THE STAGE OF THE PROCESS AND ON THE BACKGROUND OF THE PATHOLOGICAL CONDITIONS]. 61
31889704 2019
26
A Case Report of Pneumococcal Septic Arthritis Following a Respiratory and Gastrointestinal Prodrome with Accompanying Literature Review. 61
31679684 2019
27
Notch1 Signaling Pathway Promotes Proliferation and Mediates Differentiation Direction in Hippocampus of Streptococcus pneumonia Meningitis Rats. 61
31433841 2019
28
Primary pyogenic ventriculitis caused by Streptococcal pneumoniae in adults. 61
31803684 2019
29
FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis. 61
31738885 2019
30
Risk of otitis media with effusion (OME) in children by Pseudomonas aeruginosa. 61
31229854 2019
31
When kidneys and lungs suffer together. 61
30523563 2019
32
Design, synthesis and antibacterial evaluation of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1, 2, 3-triazole side chain. 61
31323617 2019
33
Phytochemical Screening, Antibacterial Activity and Heavy Metal Analysis of Ethnomedicinal Recipes and Their Sources Used Against Infectious Diseases. 61
31717808 2019
34
Comparative Analysis of Blood Clot, Plasma Rich in Growth Factors and Platelet-Rich Fibrin Resistance to Bacteria-Induced Fibrinolysis. 61
31500263 2019
35
[The Epidemiological Profile of the Isolation of 'Problem' Microorganisms]. 61
31493364 2019
36
Environmentally benign fabrication of SnO2-CNT nanohybrids and their multifunctional efficiency as an adsorbent, catalyst and antimicrobial agent for water decontamination. 61
31506452 2019
37
Multiscale Computational Study on the Catalytic Mechanism of the Nonmetallo Amidase Maleamate Amidohydrolase (NicF). 61
31433182 2019
38
Prevalence of Immunodeficiency in Children With Invasive Pneumococcal Disease in the Pneumococcal Vaccine Era: A Systematic Review. 61
31566672 2019
39
Rapid Streptococcus Pneumonia Antigen Detection on Postmortem Urine in a Death Due to Pneumococcal Meningitis. 61
30663991 2019
40
Influenza a virus and Streptococcus pneumonia coinfection potentially promotes bacterial colonization and enhances B lymphocyte depression and reduction. 61
31637902 2019
41
Empyema necessitans in a six-month-old girl. 61
29790830 2019
42
Protective potency of recombinant meningococcal IgA1 protease and its structural derivatives upon animal invasion with meningococcal and pneumococcal infections. 61
30797878 2019
43
Antimicrobial sensitivity pattern, demographic findings and risk factors amongst meningitis and non-meningitis invasive Streptococcus pneumoniae at Aga Khan University Hospital Clinical Laboratory, Karachi, Pakistan. 61
31431765 2019
44
[Screening and antibiotic resistance analysis of nasal colonized bacteria in patients with chronic rhinosinusitis]. 61
31446729 2019
45
First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of Streptococcus pneumoniae. 61
31405060 2019
46
Antimicrobial stewardship approach: Prevalence of antimicrobial resistant bacteria at a regional hospital in South Africa. 61
32069260 2019
47
Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations. 61
31409845 2019
48
Trends in antimicrobial resistance of bacterial pathogens in Harare, Zimbabwe, 2012-2017: a secondary dataset analysis. 61
31455256 2019
49
Retrospective evaluation of the clinical presentation, magnetic resonance imaging findings, and outcome of dogs diagnosed with intracranial empyema (2008-2015): 9 cases. 61
31218823 2019
50
Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD). 61
31362724 2019

Variations for Streptococcus Pneumonia

Expression for Streptococcus Pneumonia

Search GEO for disease gene expression data for Streptococcus Pneumonia.

Pathways for Streptococcus Pneumonia

Pathways related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 TRAF6 TNF IL6 IL1B IL17A IL10
2
Show member pathways
13.74 TNF TLR4 IL6 IL1B IL17A IL10
3
Show member pathways
13.7 TRAF6 TLR9 TLR8 TLR7 TLR6 TLR5
4
Show member pathways
13.45 TRAF6 TNF IL6 IL1B IL17A IL10
5
Show member pathways
13.41 TNF IL6 IL1B IL17A IL10 CXCL8
6
Show member pathways
13.41 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
7
Show member pathways
13.22 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
8
Show member pathways
13.13 TRAF6 TNF TLR4 TLR3 TLR2 IL6
9
Show member pathways
13.06 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
10
Show member pathways
13.03 TRAF6 TNF TLR9 TLR7 TLR4 TLR3
11
Show member pathways
13 TNF IL6 IL1B IL17A IL10 CXCL8
12
Show member pathways
12.95 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
13 12.94 TRAF6 TNF TLR9 TLR3 TLR2 IL6
14
Show member pathways
12.87 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
15
Show member pathways
12.83 TRAF6 TNF TLR9 TLR4 TLR2 IL6
16
Show member pathways
12.82 TNF TLR5 TLR4 TLR2 IL6 IL1B
17
Show member pathways
12.8 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
18
Show member pathways
12.8 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
19 12.78 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
20
Show member pathways
12.73 TNF IL6 IL1B IL17A IL10 CD4
21
Show member pathways
12.65 TRAF6 TLR9 TLR8 TLR7 TLR6 TLR5
22 12.58 TRAF6 TNF TLR9 TLR6 TLR5 TLR4
23
Show member pathways
12.57 TRAF6 TNF TLR5 TLR2 IL6 IL1B
24 12.56 TRAF6 TNF TLR5 TLR4 IL1B CXCL8
25
Show member pathways
12.52 TRAF6 TNF TLR4 TLR3 IL6 IL1B
26
Show member pathways
12.5 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
27 12.49 TRAF6 TNF TLR5 TLR4 IL6 IL1B
28 12.49 TRAF6 TNF TLR9 TLR6 TLR4 TLR2
29 12.47 TNF TLR9 TLR8 TLR7 TLR6 TLR5
30
Show member pathways
12.46 TNF IL6 IL10 CXCL8 CCR6
31
Show member pathways
12.44 TRAF6 TNF TLR4 TLR2 IL1B IL10
32
Show member pathways
12.44 TNF TLR9 TLR8 IL6 IL1B IL10
33 12.42 TRAF6 TNF TLR4 IL6 IL1B CXCL8
34
Show member pathways
12.4 TNF IL6 IL1B IL17A IL10 CXCL8
35
Show member pathways
12.4 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
36
Show member pathways
12.38 TLR2 TLR1 CD4 CCR6
37
Show member pathways
12.35 TNF TLR4 TLR3 IL1B CYLD
38 12.32 TNF IL6 IL1B IL10 CXCL8
39
Show member pathways
12.32 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
40 12.27 TRAF6 TNF TLR4 IL6 IL1B IL10
41
Show member pathways
12.25 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
42 12.21 TNF IL6 IL1B IL17A IL10 CXCL8
43 12.18 TNF TLR4 IL6 IL1B CXCL8
44 12.17 TNF TLR4 TLR2 IL6 IL1B IL10
45 12.16 TRAF6 TNF TLR4 IL1B CYLD CXCL8
46
Show member pathways
12.16 TNF TLR9 TLR8 TLR7 TLR6 TLR5
47 12.15 TRAF6 TNF IL1B CYLD
48 12.13 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
49 12.12 TNF TLR4 TLR2 IL6 IL1B IL17A
50 12.1 TNF IL6 IL10 CD4

GO Terms for Streptococcus Pneumonia

Cellular components related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.25 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
2 cytoplasmic vesicle GO:0031410 9.93 TLR9 TLR7 TLR6 TLR2 TLR1 IL1B
3 cell surface GO:0009986 9.91 TNF TLR4 TLR3 TLR2 CD4 CCR6
4 integral component of plasma membrane GO:0005887 9.81 TNF TLR6 TLR5 TLR4 TLR3 TLR2
5 external side of plasma membrane GO:0009897 9.73 TNF TLR8 TLR4 IL17A CD4 CCR6
6 membrane raft GO:0045121 9.72 TNF TLR6 TLR2 TLR1 CD4
7 phagocytic vesicle membrane GO:0030670 9.65 TLR6 TLR2 TLR1
8 endosome membrane GO:0010008 9.43 TRAF6 TLR9 TLR8 TLR7 TLR4 TLR3
9 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.37 TLR2 TLR1
10 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3

Biological processes related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.4 TRAF6 TLR9 TLR8 TLR7 TLR6 TLR5
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.37 TRAF6 TNF TLR9 TLR4 TLR3 TLR2
3 innate immune response GO:0045087 10.32 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
4 immune system process GO:0002376 10.3 TRAF6 TLR9 TLR8 TLR7 TLR6 TLR5
5 positive regulation of gene expression GO:0010628 10.27 TNF TLR9 TLR6 TLR4 TLR3 TLR2
6 cytokine-mediated signaling pathway GO:0019221 10.23 TRAF6 TNF IL6 IL1B IL17A IL10
7 defense response to bacterium GO:0042742 10.2 TNF TLR9 TLR6 TLR5 TLR4 TLR3
8 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.19 TRAF6 TNF TLR9 TLR6 TLR4 TLR3
9 negative regulation of cell proliferation GO:0008285 10.18 TLR2 IL6 IL1B IL10 CXCL8
10 cellular response to lipopolysaccharide GO:0071222 10.18 TRAF6 TNF TLR5 TLR4 IL6 IL1B
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.13 TRAF6 TNF TLR9 TLR6 TLR4 TLR3
12 defense response to virus GO:0051607 10.12 TLR9 TLR8 TLR7 TLR3 IL6
13 positive regulation of JNK cascade GO:0046330 10.12 TRAF6 TNF TLR9 TLR4 TLR3 IL1B
14 cellular response to mechanical stimulus GO:0071260 10.11 TLR8 TLR7 TLR5 TLR4 TLR3 IL1B
15 positive regulation of inflammatory response GO:0050729 10.11 TNF TLR9 TLR7 TLR4 TLR3 TLR2
16 positive regulation of DNA-binding transcription factor activity GO:0051091 10.09 TRAF6 TNF IL6 IL1B IL10
17 I-kappaB kinase/NF-kappaB signaling GO:0007249 10.08 TRAF6 TNF TLR9 TLR8 TLR7 TLR4
18 response to lipopolysaccharide GO:0032496 10.07 TLR4 TLR2 IL1B IL10
19 defense response GO:0006952 10.06 TNF TLR3 TLR1 CXCL8
20 positive regulation of interleukin-6 secretion GO:2000778 10.06 TNF TLR8 TLR4 TLR2 IL1B IL17A
21 activation of MAPK activity GO:0000187 10.05 TRAF6 TNF TLR4 IL1B
22 positive regulation of nitric oxide biosynthetic process GO:0045429 10.05 TNF TLR6 TLR5 TLR4 IL1B
23 defense response to Gram-negative bacterium GO:0050829 10.03 TLR9 TLR4 IL6 CD4
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.03 TNF TLR6 TLR4 IL6 IL17A
25 positive regulation of NIK/NF-kappaB signaling GO:1901224 10.03 TRAF6 TNF TLR9 TLR7 TLR4 TLR3
26 microglial cell activation GO:0001774 10.02 TNF TLR8 TLR7 TLR6 TLR3 TLR2
27 positive regulation of T cell proliferation GO:0042102 10.01 TRAF6 IL6 IL1B CD4
28 positive regulation of tumor necrosis factor production GO:0032760 10 TLR9 TLR4 TLR3 TLR2
29 positive regulation of interleukin-6 biosynthetic process GO:0045410 10 TRAF6 TNF TLR6 TLR1 IL1B
30 positive regulation of interleukin-8 biosynthetic process GO:0045416 10 TNF TLR9 TLR8 TLR7 TLR4
31 positive regulation of JUN kinase activity GO:0043507 9.99 TRAF6 TNF TLR9 TLR6
32 negative regulation of interleukin-6 production GO:0032715 9.99 TNF TLR9 TLR4 IL10
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.98 TNF TLR4 TLR2 IL1B
34 positive regulation of interferon-beta production GO:0032728 9.98 TLR9 TLR4 TLR3 TLR2
35 positive regulation of interleukin-12 production GO:0032735 9.97 TLR9 TLR4 TLR3 TLR2
36 positive regulation of interleukin-8 secretion GO:2000484 9.97 TNF TLR4 TLR2 TLR1
37 positive regulation of interleukin-8 production GO:0032757 9.97 TNF TLR9 TLR7 TLR5 TLR4 TLR3
38 positive regulation of interleukin-6 production GO:0032755 9.97 TNF TLR9 TLR8 TLR7 TLR4 TLR3
39 apoptotic signaling pathway GO:0097190 9.96 TNF TLR4 TLR3
40 toll-like receptor 9 signaling pathway GO:0034162 9.96 TRAF6 TLR9 TLR8 TLR7
41 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.96 TLR9 TLR8 TLR7 TLR3
42 I-kappaB phosphorylation GO:0007252 9.96 TLR9 TLR7 TLR4 TLR3 TLR2
43 response to glucocorticoid GO:0051384 9.95 TNF IL6 IL10
44 regulation of protein phosphorylation GO:0001932 9.95 TNF TLR8 TLR7
45 positive regulation of smooth muscle cell proliferation GO:0048661 9.95 TRAF6 TNF IL6
46 humoral immune response GO:0006959 9.95 TNF IL6 CCR6
47 response to molecule of bacterial origin GO:0002237 9.95 TLR9 TLR2 IL10 CXCL8
48 positive regulation of chemokine production GO:0032722 9.95 TNF TLR9 TLR7 TLR4 TLR3 TLR2
49 positive regulation of interferon-gamma production GO:0032729 9.94 TNF TLR4 IL1B
50 regulation of cytokine secretion GO:0050707 9.93 TLR9 TLR8 TLR6 TLR5 TLR2 TLR1

Molecular functions related to Streptococcus Pneumonia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.4 TRAF6 TNF TLR9 TLR8 TLR7 TLR6
2 identical protein binding GO:0042802 10.1 TRAF6 TNF TLR6 TLR4 TLR3 TLR2
3 cytokine activity GO:0005125 9.85 TNF IL6 IL1B IL17A IL10 CXCL8
4 amyloid-beta binding GO:0001540 9.71 TLR6 TLR4 TLR2
5 double-stranded RNA binding GO:0003725 9.7 TLR8 TLR7 TLR3
6 interleukin-1 receptor binding GO:0005149 9.63 TLR9 TLR5 IL1B
7 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.62 TLR6 TLR4 TLR2 TLR1
8 lipopeptide binding GO:0071723 9.61 TLR6 TLR2 TLR1
9 transmembrane signaling receptor activity GO:0004888 9.61 TLR9 TLR8 TLR7 TLR6 TLR5 TLR4
10 NAD(P)+ nucleosidase activity GO:0050135 9.56 TLR6 TLR4 TLR2 TLR1
11 siRNA binding GO:0035197 9.55 TLR9 TLR7
12 lipopolysaccharide receptor activity GO:0001875 9.51 TLR4 TLR2
13 Toll-like receptor 2 binding GO:0035663 9.48 TLR6 TLR1
14 pattern recognition receptor activity GO:0038187 9.46 TLR9 TLR8 TLR7 TLR2
15 signaling receptor activity GO:0038023 9.28 TLR8 TLR6 TLR5 TLR4 TLR3 TLR2

Sources for Streptococcus Pneumonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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