MCID: STR067
MIFTS: 82

Stroke, Ischemic

Categories: Genetic diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Stroke, Ischemic

MalaCards integrated aliases for Stroke, Ischemic:

Name: Stroke, Ischemic 57 41 38
Cerebral Infarction 57 41 12 75 55 44 15 73
Stroke 57 54 29 55 6 43 3 63
Ischemic Stroke 57 75 29 6 43 73
Cerebrovascular Accident 57 41 75 73
Cerebral Infarction, Susceptibility to 57 13 6
Stroke, Ischemic, Susceptibility to 57 29 40
Ischemic Stroke, Susceptibility to 57 6
Ischemic Cerebrovascular Accident 73
Stroke, Susceptibility to 57
Cva - Cerebral Infarction 12
Cerebral Infarct 12
Ischstr 75

Characteristics:

OMIM:

57
Inheritance:
multifactorial predisposition


Classifications:



Summaries for Stroke, Ischemic

MedlinePlus : 43 A stroke is a medical emergency. Strokes happen when blood flow to your brain stops. Within minutes, brain cells begin to die. There are two kinds of stroke. The more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. The other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "Mini-strokes" or transient ischemic attacks (TIAs), occur when the blood supply to the brain is briefly interrupted. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause If you have any of these symptoms, you must get to a hospital quickly to begin treatment. Acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. Post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. Drug therapy with blood thinners is the most common treatment for stroke. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Stroke, Ischemic, also known as cerebral infarction, is related to neonatal stroke and sneddon syndrome, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Angiotensin II and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include Bone and Umbilical Cord, and related phenotypes are stroke and homeostasis/metabolism

OMIM : 57 A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. Gunel and Lifton (1996) noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano et al. (2008) reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309), the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see, e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519). (601367)

CDC : 3 Stroke is the fifth leading cause of death in the United States and is a major cause of serious disability for adults.1,2 About 795,000 people in the United States have a stroke each year.2Get more quick facts about stroke.

NINDS : 54 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: ischemic - blockage of a blood vessel supplying the brain, and hemorrhagic - bleeding into or around the brain.

UniProtKB/Swiss-Prot : 75 Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

PubMed Health : 63 About stroke: A stroke occurs if the flow of oxygen-rich blood to a portion of the brain is blocked. Without oxygen, brain cells start to die after a few minutes. Sudden bleeding in the brain also can cause a stroke if it damages brain cells.If brain cells die or are damaged because of a stroke, symptoms occur in the parts of the body that these brain cells control. Examples of stroke symptoms include sudden weakness; paralysis or numbness of the face, arms, or legs (paralysis is an inability to move); trouble speaking or understanding speech; and trouble seeing.A stroke is a serious medical condition that requires emergency care. A stroke can cause lasting brain damage, long-term disability, or even death.If you think you or someone else is having a stroke, call 9–1–1 right away. Do not drive to the hospital or let someone else drive you. Call an ambulance so that medical personnel can begin life-saving treatment on the way to the emergency room. During a stroke, every minute counts.

Related Diseases for Stroke, Ischemic

Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 neonatal stroke 35.3 MTHFR SERPINE1
2 sneddon syndrome 35.0 APOH F2 F5 SERPINC1
3 cerebrovascular disease 34.1 ACE F2 F5 MTHFR NOTCH3 PDE4D
4 intracranial embolism 34.0 F2 PLAT SERPINC1
5 patent foramen ovale 32.0 F2 F5 MTHFR SERPINC1
6 acute myocardial infarction 31.8 ACE CDKN2B-AS1 PLAT SERPINC1 SERPINE1
7 myocardial infarction 31.6 ACE ALOX5AP CDKN2B-AS1 F2 F5 MIAT
8 ischemic heart disease 31.4 ACE F2 NOS3
9 heart disease 31.3 ACE F2 FBN1 MTHFR NOS3 SERPINC1
10 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 12.4
11 pediatric arterial ischemic stroke 12.3
12 mini stroke 12.2
13 atrial fibrillation and stroke 12.1
14 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 12.1
15 hereditary endotheliopathy, retinopathy, nephropathy, and stroke 12.0
16 cerebral sinovenous thrombosis 11.4 APOH F2 F5
17 sagittal sinus thrombosis 11.4 F2 F5 SERPINC1
18 paracetamol poisoning 11.3 F2 F5
19 inferior vena cava interruption 11.3 F5 MTHFR SERPINE1
20 may-thurner syndrome 11.3 APOH F5
21 porencephaly 11.3 F2 F5 MTHFR
22 sudden sensorineural hearing loss 11.3 F2 F5 MTHFR SERPINC1
23 amaurosis fugax 11.3 F5 MTHFR SERPINE1
24 prothrombin deficiency, congenital 11.3 APOH F2 F5 SERPINC1
25 ischemic colitis 11.3 APOH F2 F5 SERPINC1
26 blood protein disease 11.3 F2 MTHFR SERPINC1
27 aortic coarctation 11.3 ACE FBN1 NOS3
28 carotid artery occlusion 11.3 APOH F5 NOS3
29 fibrinolytic defect 11.3 PLAT SERPINC1 SERPINE1
30 cryptogenic cirrhosis 11.3 F2 F5 MTHFR SERPINE1
31 sticky platelet syndrome 11.3 F5 SERPINC1 SERPINE1
32 prothrombin deficiency 11.3 APOH F2 F5 SERPINC1
33 peripheral vertigo 11.3 APOH F2 F5 SERPINC1
34 dysfibrinogenemia 11.3 F2 F5 PLAT SERPINC1
35 blue toe syndrome 11.3 F2 SERPINC1 SERPINE1
36 acanthamoeba keratitis 11.3 APOH F5
37 hepatoportal sclerosis 11.3 ACE F2
38 post-thrombotic syndrome 11.3 F2 F5 SERPINC1 SERPINE1
39 protein c deficiency 11.3 F2 F5 MTHFR SERPINC1
40 arteritic anterior ischemic optic neuropathy 11.3 ACE F2 F5 MTHFR NOS3
41 subendocardial myocardial infarction 11.3 F2 SERPINC1 SERPINE1
42 thrombasthenia 11.3 F2 F5 MTHFR
43 blood coagulation disease 11.3 F2 F5 MTHFR SERPINC1
44 carotid artery thrombosis 11.3 NOS3 PLAT SERPINE1
45 argentine hemorrhagic fever 11.3 PLAT SERPINC1 SERPINE1
46 pulmonary edema 11.3 ACE F2 NOS3 SERPINC1
47 coronary restenosis 11.3 ACE PLAT SERPINC1
48 marantic endocarditis 11.3 F2 MTHFR PLAT SERPINC1
49 factor x deficiency 11.3 F2 F5 SERPINC1
50 catastrophic antiphospholipid syndrome 11.3 APOH F5 MTHFR SERPINE1

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to Stroke, Ischemic

Symptoms & Phenotypes for Stroke, Ischemic

Symptoms via clinical synopsis from OMIM:

57
Neuro:
stroke
motor, sensory and/or cognitive function loss


Clinical features from OMIM:

601367

Human phenotypes related to Stroke, Ischemic:

32
# Description HPO Frequency HPO Source Accession
1 stroke 32 HP:0001297

UMLS symptoms related to Stroke, Ischemic:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, equilibration disorder, sleeplessness

MGI Mouse Phenotypes related to Stroke, Ischemic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ACE ALOX5AP APOH F2 F5 FBN1
2 cardiovascular system MP:0005385 10.2 ACE F2 F5 FBN1 NOS3 NOTCH3
3 growth/size/body region MP:0005378 10.17 ACE F2 F5 FBN1 MTHFR NOS3
4 hematopoietic system MP:0005397 10.1 SERPINE1 ACE ALOX5AP F2 FBN1 NOS3
5 immune system MP:0005387 10.06 ACE ALOX5AP F2 FBN1 NOS3 NOTCH3
6 mortality/aging MP:0010768 9.97 ACE APOH F2 F5 FBN1 MTHFR
7 integument MP:0010771 9.91 F5 FBN1 MTHFR NOTCH3 PIK3CA PLAT
8 renal/urinary system MP:0005367 9.5 ACE FBN1 NOS3 NOTCH3 PTGIS SERPINC1
9 reproductive system MP:0005389 9.28 ACE F2 FBN1 MTHFR NOS3 NOTCH3

Drugs & Therapeutics for Stroke, Ischemic

PubMedHealth treatment related to Stroke, Ischemic: 63

Treatment for a stroke depends on whether it is ischemic or hemorrhagic. Treatment for a transient ischemic attack (TIA) depends on its cause, how much time has passed since symptoms began, and whether you have other medical conditions.Strokes and TIAs are medical emergencies. If you have stroke symptoms, call 9–1–1 right away. Do not drive to the hospital or let someone else drive you. Call an ambulance so that medical personnel can begin life-saving treatment on the way to the emergency room. During a stroke, every minute counts.Once you receive initial treatment, your doctor will try to treat your stroke risk factors and prevent complications.

Drugs for Stroke, Ischemic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 635)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
3
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
4
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-66-6 23994
5
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
6 Nadroparin Approved, Investigational Phase 4 9041-08-1
7
Atenolol Approved Phase 4 29122-68-7 2249
8
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Not Applicable 73963-72-1 2754
10
Probucol Approved, Investigational Phase 4 23288-49-5 4912
11
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 120202-66-6, 113665-84-2 60606
12
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 55142-85-3 5472
13
Colchicine Approved Phase 4,Phase 3 64-86-8 6167 2833
14
Menthol Approved Phase 4,Phase 3,Early Phase 1,Not Applicable 2216-51-5 16666
15
Nimodipine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 66085-59-4 4497
16
Nicardipine Approved, Investigational Phase 4,Phase 3,Not Applicable 55985-32-5 4474
17
Amlodipine Approved Phase 4,Phase 2,Not Applicable 88150-42-9 2162
18
Rivaroxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 366789-02-8
19
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
20
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 6691 54678486
21
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
22
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
23
Abciximab Approved Phase 4,Phase 3,Phase 2 143653-53-6
24
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
25
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
26
Enoxaparin Approved Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772
27
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
28
Dipyridamole Approved Phase 4,Phase 3,Phase 2,Not Applicable 58-32-2 3108
29
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
30
Apixaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 503612-47-3 10182969
31
Enalapril Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 75847-73-3 5362032 40466924
32
Enalaprilat Approved Phase 4,Phase 3,Phase 2,Not Applicable 76420-72-9 6917719
33
Ethanol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 64-17-5 702
34
Pitavastatin Approved Phase 4,Phase 3,Not Applicable 147511-69-1, 147526-32-7 6366718 5282452
35 Edoxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 480449-70-5
36
Glyburide Approved Phase 4,Phase 2,Phase 1 10238-21-8 3488
37
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
38
Acenocoumarol Approved, Investigational Phase 4,Phase 3,Not Applicable 152-72-7 9052 54676537
39
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 113775-47-6 68602 5311068
40
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 437-38-7 3345
41
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 137-58-6 3676
42
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Not Applicable 59467-70-8 4192
43
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
44
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
45
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
46 Piracetam Approved, Investigational Phase 4 7491-74-9
47
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
48
Saxagliptin Approved Phase 4 361442-04-8 11243969
49
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 75614-87-8, 51-45-6 774
50
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 74863-84-6 152951

Interventional clinical trials:

(show top 50) (show all 1883)
# Name Status NCT ID Phase Drugs
1 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
2 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
3 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
4 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
5 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
6 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
7 Exploratory Study on the Effects of Early Rosuvastatin Treatment in Patients With Acute Ischemic Stroke Unknown status NCT02643784 Phase 4 Rosuvastatin
8 Preventive Effects of Ginseng Against Atherosclerosis Unknown status NCT02796664 Phase 4
9 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
10 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
11 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
12 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
13 The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke Unknown status NCT02452502 Phase 4
14 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
15 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
16 Clopidogrel for Acute Ischaemia of Recent Onset Unknown status NCT02776540 Phase 4 Clopidogrel;Aspirin
17 Colchicine for Acute Coronary Syndromes Unknown status NCT01906749 Phase 4 Colchicine;Placebo
18 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
19 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
20 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
21 Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients Unknown status NCT01394770 Phase 4 Aliskiren
22 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
23 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
24 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging Unknown status NCT02041117 Phase 4 Rosuvastatin
25 Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT02594800 Phase 4 Rosuvastatin
26 Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation Unknown status NCT00776633 Phase 4 aspirin;clopidogrel;oral anticoagulation
27 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
28 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
29 Optimal Anti-platelet Treatment for Patients With Clopidogrel Low Response Unknown status NCT01955200 Phase 4 Ticagrelor;Clopidogrel;Cilostazol;Clopidogrel;Clopidogrel
30 Acute Candesartan Cilexetil Outcomes Stroke Trial (ACCOST) Unknown status NCT00108706 Phase 4 Candesartan
31 Exploring Efficacy of Intensive Rosuvastatin Treatment Peri-PCI in Chinese Patients With Non ST-segment Elevated Acute Coronary Syndrome(NSTE-ACS) Unknown status NCT02284503 Phase 4 Rosuvastatin
32 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
33 Anti-inflammatory Effects of Rivaroxaban Versus Dabigatran Unknown status NCT02331602 Phase 4 Rivaroxaban;Dabigatran
34 Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMI Unknown status NCT01158846 Phase 4 prasugrel/bivalirudin;clopidogrel/abciximab
35 The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels Unknown status NCT01926834 Phase 4 Erigeron Injection;placebo
36 The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized and Cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction Unknown status NCT02411903 Phase 4 atorvastatin and clopidogrel;rosuvastatin and clopidogrel
37 A Randomized Double Blind Placebo Control Study of Huang-Chi-Wu-Wu- Tang in Patients With Intracranial Arterial Stenosis Unknown status NCT01553643 Phase 4 Chinese Herb Huang-Chi-Wu-Wu-Tang;placebo
38 Registry for Estimation of Warfarin and Rivaroxaban in Atrial Fibrillation Patients With Coronary Stent Implantation Unknown status NCT02024230 Phase 4 Warfarin or Rivaroxaban
39 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
40 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
41 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
42 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
43 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
44 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
45 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
46 Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients Completed NCT03385538 Phase 4 Clopidogrel
47 AdminiStration of Statin On Acute Ischemic stRoke patienT Trial Completed NCT02549846 Phase 4 Statin
48 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
49 The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED) Completed NCT00754429 Phase 4 losartan;amlodipine
50 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Cerecellgram-Stroke, bone marrow-derived mesenchymal stem cells for treatment of ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905
Bone marrow-derived mononuclear cells (family) PMIDs: 22960888
Bone marrow-derived mononuclear cells PMIDs: 17635049
Bone marrow-derived mononuclear cells PMIDs: 20629187 20395386
Bone marrow-derived mesenchymal stem cells (Cerecellgram-Stroke)
Neural stem cells PMIDs: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285
Fetal spinal cord stem cells (NSI-566) PMIDs: 22415942 19326469
Olfactory ensheathing cells
Placenta-derived cells
Neural stem cell line (CTX0E03) PMIDs: 19633272 23185625 17981710
Notch-transfected mesenchymal stromal cells (SB623) PMIDs: 19530164 23430693 20350349 21982515
Trophic factor-induced mesenchymal stem cells PMIDs: 19530164 23430693 20350349 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne PMIDs: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Cochrane evidence based reviews: cerebral infarction

Genetic Tests for Stroke, Ischemic

Genetic tests related to Stroke, Ischemic:

# Genetic test Affiliating Genes
1 Ischemic Stroke 29 ALOX5AP F2 F5 NOS3 PRKCH
2 Stroke 29
3 Stroke, Ischemic, Susceptibility to 29

Anatomical Context for Stroke, Ischemic

MalaCards organs/tissues related to Stroke, Ischemic:

41
Brain, Bone, Heart, Endothelial, Bone Marrow, Eye, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells

Publications for Stroke, Ischemic

Articles related to Stroke, Ischemic:

(show top 50) (show all 996)
# Title Authors Year
1
Cerebral infarction following cyanoacrylate endoscopic therapy of duodenal varices in a patient with a patent foramen ovale. ( 29948836 )
2018
2
Multiple Cerebral Infarctions Due to Patent Foramen Ovale in a Patient with Eosinophilic Granulomatosis with Polyangiitis. ( 29373226 )
2018
3
Large pulmonary arteriovenous malformation with paradoxical cerebral infarction. ( 29534345 )
2018
4
Reversible Parkinsonism and Multiple Cerebral Infarctions after Pulmonary Endarterectomy in a Patient with Antiphospholipid Syndrome. ( 29321405 )
2018
5
Pulmonary arteriovenous fistula complicated by venous thromboembolism and paradoxical cerebral infarction during early pregnancy. ( 29437680 )
2018
6
Silent cerebral infarct definitions and full-scale IQ loss in children with sickle cell anemia. ( 29263226 )
2018
7
Stroke, Ischemic ( 29763173 )
2018
8
Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect. ( 29636612 )
2018
9
A devastating case of diarrhea-associated hemolytic uremic syndrome associated with extensive cerebral infarction; why we need to do better. ( 28599619 )
2017
10
A Successfully Treated Case of Gastrointestinal Stromal Tumor Causing Severe Anemia and Localized Peritonitis Showing Angina Pectoris Resulting in Watershed Cerebral Infarction. ( 28912818 )
2017
11
GPVIa89Fca89PEG improves cerebral infarct volume and cerebral thrombosis in mouse model with cerebral thrombosis. ( 28944903 )
2017
12
Recurrent Cerebral Infarction in Anterior and Posterior Circulation Territories Associated with Persistent Primitive Hypoglossal Artery and Carotid Artery Dissection: A Case Report. ( 29166846 )
2017
13
ANCA-Negative Churg-Strauss Syndrome Presenting as Acute Multiple Cerebral Infarcts: A Case Report. ( 28065613 )
2017
14
Intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator (rt-PA) therapy for acute cerebral infarction in a patient with ANCA-associated vasculitis. ( 28740062 )
2017
15
Promoter hypomethylation of microRNA223 gene is associated with atherosclerotic cerebral infarction. ( 28683362 )
2017
16
Hypertensive encephalopathy mimicking cerebral vasculitis with pontine oedema, cerebellar white matter lesions and multiple cerebral infarctions. ( 28724595 )
2017
17
Serum Resistin Levels May Contribute to an Increased Risk of Acute Cerebral Infarction. ( 26899574 )
2017
18
Higher Serum Uric Acid May Contribute to Cerebral Infarction in Patients with Type 2 Diabetes Mellitus: a Meta-Analysis. ( 27696108 )
2017
19
Obstructive sleep apnea and silent cerebral infarction in hypertensive individuals. ( 28631309 )
2017
20
A case of Plasmodium vivax malaria presenting as acute cerebral infarct. ( 28748845 )
2017
21
Posttraumatic cerebral infarction after decompressive craniectomy for traumatic brain injury: incidence, risk factors and outcome. ( 28944947 )
2017
22
The Expression of microRNA-223 and FAM5C in Cerebral Infarction Patients with Diabetes Mellitus. ( 26717922 )
2017
23
Cisplatin-related Cerebral Infarction in Testicular Germ Cell Cancer: Short Report of Three Cases and P in testicular germ cell cancer: Short report of three cases and pathomechanism. ( 27923208 )
2017
24
Importance of Distinguishing Between Mitochondrial Encephalomyopathy With Elderly Onset of Stroke-Like Episodes and Cerebral Infarction. ( 28811861 )
2017
25
RBP4/Lp-PLA2/Netrin-1 signaling regulation of cognitive dysfunction in diabetic nephropathy complicated with silent cerebral infarction. ( 28704853 )
2017
26
Cerebral Infarct Topography and Early Outcome after Surgery for Symptomatic Carotid Stenosis: A Multicentre Study. ( 28910807 )
2017
27
Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction. ( 29076904 )
2017
28
Higher prevalence of spontaneous cerebral vasculopathy and cerebral infarcts in a mouse model of sickle cell disease. ( 28925802 )
2017
29
Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. ( 28007413 )
2017
30
Multiple Thromboembolic Cerebral Infarctions from the Aorta in a Patient with Churg-Strauss Syndrome. ( 27993446 )
2017
31
Circulating protein Z concentration, PROZ variants, and unexplained cerebral infarction in young and middle-aged adults. ( 27683756 )
2017
32
Middle cerebral artery dissection causing subarachnoid hemorrhage and cerebral infarction: Trapping with high-flow bypass preserving the lenticulostriate artery. ( 28808606 )
2017
33
Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population. ( 28552715 )
2017
34
Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction. ( 28215748 )
2017
35
Association of the LOX-1 rs1050283 Polymorphism with Risk for Atherosclerotic Cerebral Infarction and its Effect on sLOX-1 and LOX-1 Expression in a Chinese Population. ( 27840386 )
2017
36
A Cerebral Infarction in a Girl With Sturge-Weber Syndrome. ( 27663490 )
2016
37
Cerebral infarction pattern in tuberculous meningitis. ( 27958312 )
2016
38
The D9N, N291S, and T495G Polymorphisms of the Lipoprotein Lipase Gene Are Not Associated with Cerebral Infarction. ( 26853140 )
2016
39
Multiple Cerebral Infarctions in a Patient with Adenomyosis on Hormone Replacement Therapy: A Case Report. ( 27520610 )
2016
40
Associations between hematopoietic growth factors and risks of venous thromboembolism, stroke, ischemic heart disease and myelodysplastic syndrome: findings from a large population-based cohort of women with breast cancer. ( 27059219 )
2016
41
Vasculitis, cerebral infarction and persistent Bartonella henselae infection in a child. ( 27161220 )
2016
42
Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study. ( 26253723 )
2016
43
Copeptin Levels in Cerebral Infarction, Intracranial Hemorrhage and Subarachnoid Hemorrhage. ( 28164562 )
2016
44
Significance of decreased serum interleukin-10 levels in the progression of cerebral infarction. ( 25847570 )
2016
45
[Association of extracellular superoxide dismutase gene methylation with cerebral infarction]. ( 27264826 )
2016
46
Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction. ( 25916953 )
2016
47
Plasma MicroRNA-16 Is a Biomarker for Diagnosis, Stratification, and Prognosis of Hyperacute Cerebral Infarction. ( 27846323 )
2016
48
Elevated Adiponectin Antibody Levels in Sera of Patients with Atherosclerosis-Related Coronary Artery Disease, Cerebral Infarction and Diabetes Mellitus. ( 28936256 )
2016
49
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
50
Multiple cerebral infarctions in a patient with idiopathic thrombocytopenic purpura. ( 27648181 )
2016