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ISCHSTR
MCID: STR067
MIFTS: 85

Stroke, Ischemic (ISCHSTR)

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Metabolic diseases, Neuronal diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Stroke, Ischemic

About this section

MalaCards integrated aliases for Stroke, Ischemic:

Name: Stroke, Ischemic 57 41 38
Cerebral Infarction 57 41 12 75 55 44 15 73
Stroke 57 54 29 55 6 43 3 63
Ischemic Stroke 57 75 29 6 43 73
Cerebrovascular Accident 57 41 75 73
Cerebral Infarction, Susceptibility to 57 13 6
Stroke, Ischemic, Susceptibility to 57 29 40
Ischemic Stroke, Susceptibility to 57 6
Ischemic Cerebrovascular Accident 73
Stroke, Susceptibility to 57
Cva - Cerebral Infarction 12
Cerebral Infarct 12
Ischstr 75

Characteristics:

OMIM:

57
Inheritance:
multifactorial predisposition


Classifications:

MalaCards categories:
Global: Genetic diseases Metabolic diseases
Anatomical: Cardiovascular diseases Neuronal diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

OMIM 57 601367
Disease Ontology 12 DOID:3526
MeSH 44 D002544
NCIt 50 C50486
SNOMED-CT 68 20059004
SNOMED-CT via HPO 69 230690007
Sources

Summaries for Stroke, Ischemic

About this section
MedlinePlus : 43 A stroke is a medical emergency. Strokes happen when blood flow to your brain stops. Within minutes, brain cells begin to die. There are two kinds of stroke. The more common kind, called ischemic stroke, is caused by a blood clot that blocks or plugs a blood vessel in the brain. The other kind, called hemorrhagic stroke, is caused by a blood vessel that breaks and bleeds into the brain. "Mini-strokes" or transient ischemic attacks (TIAs), occur when the blood supply to the brain is briefly interrupted. Symptoms of stroke are Sudden numbness or weakness of the face, arm or leg (especially on one side of the body) Sudden confusion, trouble speaking or understanding speech Sudden trouble seeing in one or both eyes Sudden trouble walking, dizziness, loss of balance or coordination Sudden severe headache with no known cause If you have any of these symptoms, you must get to a hospital quickly to begin treatment. Acute stroke therapies try to stop a stroke while it is happening by quickly dissolving the blood clot or by stopping the bleeding. Post-stroke rehabilitation helps individuals overcome disabilities that result from stroke damage. Drug therapy with blood thinners is the most common treatment for stroke. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and intracranial embolism, and has symptoms including seizures, tremor and angina pectoris. An important gene associated with Stroke, Ischemic is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Valsartan and Angiotensin II have been mentioned in the context of this disorder. Affiliated tissues include Bone and Umbilical Cord, and related phenotypes are stroke and homeostasis/metabolism

Disease Ontology : 12 A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.

OMIM : 57 A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. It is said to be the third leading cause of death in the United States. Gunel and Lifton (1996) noted that about 20% of strokes are hemorrhagic, resulting in bleeding into the brain. Ischemic strokes, resulting from vascular occlusion, account for the majority of strokes. Bersano et al. (2008) reviewed genetic polymorphisms that have been implicated in the development of stroke. Candidate genes include those involved in hemostasis (see, e.g., F5; 612309), the renin-angiotensin-aldosterone system (see, e.g., ACE; 106180), homocysteine (see, e.g., MTHFR; 607093), and lipoprotein metabolism (see, e.g., APOE; 107741). See also hemorrhagic stroke, or intracerebral hemorrhage (ICH; 614519). (601367)

CDC : 3 Stroke is the fifth leading cause of death in the United States and is a major cause of serious disability for adults.1,2 About 795,000 people in the United States have a stroke each year.2Get more quick facts about stroke.

NINDS : 54 A stroke occurs when the blood supply to part of the brain is suddenly interrupted or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding brain cells. Brain cells die when they no longer receive oxygen and nutrients from the blood or there is sudden bleeding into or around the brain. The symptoms of a stroke include sudden numbness or weakness, especially on one side of the body; sudden confusion or trouble speaking or understanding speech; sudden trouble seeing in one or both eyes; sudden trouble with walking, dizziness, or loss of balance or coordination; or sudden severe headache with no known cause. There are two forms of stroke: ischemic - blockage of a blood vessel supplying the brain, and hemorrhagic - bleeding into or around the brain.

UniProtKB/Swiss-Prot : 75 Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

PubMed Health : 63 About stroke: A stroke occurs if the flow of oxygen-rich blood to a portion of the brain is blocked. Without oxygen, brain cells start to die after a few minutes. Sudden bleeding in the brain also can cause a stroke if it damages brain cells.If brain cells die or are damaged because of a stroke, symptoms occur in the parts of the body that these brain cells control. Examples of stroke symptoms include sudden weakness; paralysis or numbness of the face, arms, or legs (paralysis is an inability to move); trouble speaking or understanding speech; and trouble seeing.A stroke is a serious medical condition that requires emergency care. A stroke can cause lasting brain damage, long-term disability, or even death.If you think you or someone else is having a stroke, call 9–1–1 right away. Do not drive to the hospital or let someone else drive you. Call an ambulance so that medical personnel can begin life-saving treatment on the way to the emergency room. During a stroke, every minute counts.

Sources

Related Diseases for Stroke, Ischemic

About this section

Diseases related to Stroke, Ischemic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1394)
# Related Disease Score Top Affiliating Genes
1 sneddon syndrome 33.9 APOH F2 SERPINC1
2 intracranial embolism 32.9 F2 PLAT SERPINC1
3 cerebrovascular disease 32.8 ACE F2 F5 MTHFR NOTCH3 PDE4D
4 porencephaly 32.4 F2 F5 MTHFR
5 retinal vascular occlusion 31.8 APOH F2 F5 MTHFR SERPINC1
6 carotid artery occlusion 31.8 APOH F5 NOS3
7 buerger disease 31.6 APOH F2 MTHFR NOS3
8 myocardial infarction 31.0 ACE ALOX5AP CDKN2B-AS1 F2 F5 MIAT
9 endocarditis 30.8 APOH F2 PLAT SERPINC1
10 patent foramen ovale 30.8 APOH F2 F5 MTHFR PLAT SERPINC1
11 acute myocardial infarction 30.8 ACE CDKN2B-AS1 PLAT SERPINC1
12 vascular disease 30.7 ACE APOH F2 F5 MTHFR NOS3
13 peripheral artery disease 30.7 ACE CDKN2B-AS1 NOS3
14 cerebral sinovenous thrombosis 30.6 APOH F2 F5
15 hypertension, essential 30.6 ACE CDKN2B-AS1 NOS3 PLAT PTGIS
16 aortic coarctation 30.6 ACE FBN1 NOS3
17 carotid stenosis 30.6 ACE CDKN2B-AS1 MTHFR
18 antiphospholipid syndrome 30.6 APOH F2 F5 MTHFR PLAT SERPINC1
19 vascular dementia 30.5 ACE MTHFR NOTCH3
20 thrombosis 30.5 APOH F2 F5 MTHFR PLAT SERPINC1
21 thrombophilia due to activated protein c resistance 30.5 APOH F2 F5 MTHFR PLAT SERPINC1
22 retinal artery occlusion 30.4 ACE APOH F2 F5 MTHFR SERPINC1
23 pulmonary embolism 30.4 APOH F2 F5 MTHFR PLAT SERPINC1
24 eclampsia 30.4 F2 MTHFR SERPINC1
25 protein c deficiency 30.4 F2 F5 MTHFR SERPINC1
26 marantic endocarditis 30.4 F2 MTHFR PLAT SERPINC1
27 thrombophilia 30.4 APOH F2 F5 MTHFR SERPINC1
28 coronary artery anomaly 30.4 ACE F2 F5 NOS3 PLAT
29 migraine with aura 30.4 ACE F2 MTHFR NOS3 NOTCH3
30 antithrombin iii deficiency 30.4 APOH F2 F5 MTHFR SERPINC1
31 intermittent claudication 30.4 ACE APOH F2 SERPINC1
32 retinal vein occlusion 30.4 APOH F2 F5 MTHFR SERPINC1
33 thrombophilia due to thrombin defect 30.4 APOH F2 F5 MTHFR PLAT SERPINC1
34 intracranial hypertension 30.3 APOH F2 F5 MTHFR SERPINC1
35 arteries, anomalies of 30.3 ACE NOS3 PLAT SERPINC1
36 coronary heart disease 1 30.3 ACE CDKN2B-AS1 MTHFR NOS3 PLAT
37 purpura 30.3 APOH F2 SERPINC1
38 ischemic optic neuropathy 30.3 ACE APOH F2 F5 MTHFR NOS3
39 disseminated intravascular coagulation 30.3 F2 F5 PLAT SERPINC1
40 spinal cord infarction 30.3 APOH F2 F5 MTHFR SERPINC1
41 homocysteinemia 30.2 F2 F5 MTHFR NOS3 SERPINC1
42 portal vein thrombosis 30.2 APOH F2 F5 MTHFR SERPINC1
43 protein s deficiency 30.2 APOH F2 F5 MTHFR SERPINC1
44 homocystinuria 30.2 F5 FBN1 MTHFR SERPINC1
45 cerebral atherosclerosis 30.2 ACE MTHFR
46 sudden sensorineural hearing loss 30.2 APOH F2 F5 MTHFR
47 arteritic anterior ischemic optic neuropathy 30.1 ACE F2 F5 MTHFR NOS3
48 ischemic heart disease 30.1 ACE MTHFR NOS3
49 varicose veins 30.1 F2 F5 MTHFR SERPINC1
50 branch retinal artery occlusion 30.1 APOH F2 MTHFR SERPINC1

Graphical network of the top 20 diseases related to Stroke, Ischemic:



Diseases related to Stroke, Ischemic
Sources

Symptoms & Phenotypes for Stroke, Ischemic

About this section

Symptoms via clinical synopsis from OMIM:

57
Neuro:
stroke
motor, sensory and/or cognitive function loss


Clinical features from OMIM:

601367

Human phenotypes related to Stroke, Ischemic:

32
# Description HPO Frequency HPO Source Accession
1 stroke 32 HP:0001297

UMLS symptoms related to Stroke, Ischemic:


seizures, tremor, angina pectoris, edema, back pain, pain, chest pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, equilibration disorder, sleeplessness

MGI Mouse Phenotypes related to Stroke, Ischemic:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ACE ACSL4 ALOX5AP APOH F2 F5
2 cardiovascular system MP:0005385 10.2 ACE ACSL4 F2 F5 FBN1 NOS3
3 growth/size/body region MP:0005378 10.17 ACE ACSL4 F2 F5 FBN1 MTHFR
4 hematopoietic system MP:0005397 10.1 ACE ACSL4 ALOX5AP F2 FBN1 NOS3
5 immune system MP:0005387 10.02 ACE ALOX5AP F2 FBN1 NOS3 NOTCH3
6 mortality/aging MP:0010768 9.97 ACE ACSL4 APOH F2 F5 FBN1
7 integument MP:0010771 9.86 F2 F5 FBN1 MTHFR NOTCH3 PIK3CA
8 reproductive system MP:0005389 9.65 ACE ACSL4 F2 FBN1 MTHFR NOS3
9 skeleton MP:0005390 9.28 ACSL4 ALOX5AP F2 FBN1 MTHFR NOS3
Sources

Drugs & Therapeutics for Stroke, Ischemic

About this section

PubMedHealth treatment related to Stroke, Ischemic: 63

Treatment for a stroke depends on whether it is ischemic or hemorrhagic. Treatment for a transient ischemic attack (TIA) depends on its cause, how much time has passed since symptoms began, and whether you have other medical conditions.Strokes and TIAs are medical emergencies. If you have stroke symptoms, call 9–1–1 right away. Do not drive to the hospital or let someone else drive you. Call an ambulance so that medical personnel can begin life-saving treatment on the way to the emergency room. During a stroke, every minute counts.Once you receive initial treatment, your doctor will try to treat your stroke risk factors and prevent complications.

Drugs for Stroke, Ischemic (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 606)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
2
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
3
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 7440-66-6
4 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
5
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
6
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2 9005-49-6 772 46507594
7
Nadroparin Approved, Investigational Phase 4
8
Atenolol Approved Phase 4 29122-68-7 2249
9
Cilostazol Approved, Investigational Phase 4,Phase 3,Phase 1 73963-72-1 2754
10
Probucol Approved, Investigational Phase 4 23288-49-5 4912
11
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
12
Colchicine Approved Phase 4,Phase 3 64-86-8 6167 2833
13
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
14
Nicardipine Approved, Investigational Phase 4,Phase 3 55985-32-5 4474
15
Warfarin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81-81-2 6691 54678486
16
Amlodipine Approved Phase 4,Phase 3,Phase 2,Not Applicable 88150-42-9 2162
17
Rivaroxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 366789-02-8
18
Ticagrelor Approved Phase 4,Phase 3,Phase 2 274693-27-5 9871419
19
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 113665-84-2, 120202-66-6 60606
20
Ticlopidine Approved Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable 55142-85-3 5472
21
Phenprocoumon Approved, Investigational Phase 4 435-97-2 54680692 9908
22
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
23
Bivalirudin Approved, Investigational Phase 4,Phase 3 128270-60-0 16129704
24
Abciximab Approved Phase 4,Phase 3,Phase 2 143653-53-6
25
Apixaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 503612-47-3 10182969
26 Edoxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 480449-70-5
27
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
28
Enoxaparin Approved Phase 4,Phase 2,Phase 3,Not Applicable 9005-49-6 772
29
Midazolam Approved, Illicit Phase 4,Phase 2,Phase 3,Not Applicable 59467-70-8 4192
30
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
31
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
32
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 437-38-7 3345
34
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
35
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 113775-47-6 68602 5311068
36
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 60-80-0 2206
37
Glyburide Approved Phase 4,Phase 2,Phase 1 10238-21-8 3488
38
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
39
Phytonadione Approved, Investigational Phase 4,Phase 3 84-80-0 4812 5284607
40
leucovorin Approved Phase 4,Phase 2,Phase 3 58-05-9 6006 143
41
Argatroban Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 74863-84-6 152951
42
Allopurinol Approved Phase 4 315-30-0 2094
43
Losartan Approved Phase 4,Phase 3 114798-26-4 3961
44
Fluoxetine Approved, Vet_approved Phase 4,Phase 2,Not Applicable 54910-89-3 3386
45
Alprostadil Approved, Investigational Phase 4 745-65-3 149351 5280723
46
Saxagliptin Approved Phase 4 361442-04-8 11243969
47
Desflurane Approved Phase 4 57041-67-5 42113
48
Succinylcholine Approved Phase 4,Phase 3 306-40-1 5314
49
Etomidate Approved Phase 4,Phase 3,Not Applicable 33125-97-2 667484 36339
50
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-45-6, 75614-87-8 774

Interventional clinical trials:

(show top 50) (show all 1702)
# Name Status NCT ID Phase Drugs
1 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
2 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
3 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
4 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
5 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
6 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
7 Exploratory Study on the Effects of Early Rosuvastatin Treatment in Patients With Acute Ischemic Stroke Unknown status NCT02643784 Phase 4 Rosuvastatin
8 Preventive Effects of Ginseng Against Atherosclerosis Unknown status NCT02796664 Phase 4
9 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
10 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
11 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
12 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
13 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
14 The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke Unknown status NCT02452502 Phase 4
15 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
16 Intensive Statin Treatment in Acute Ischemic Stroke Patients With INtracranial Atherosclerosis Unknown status NCT02458755 Phase 4 High-dose statin: Atorvastatin 40mg or Rosuvastatin 20mg
17 Safety Study of Melatonin in Stroke Patients Unknown status NCT01863277 Phase 4 Melatonin;placebo
18 Assess the Penumbra System in the Treatment of Acute Stroke Unknown status NCT01429350 Phase 4 intravenous (IV) recombinant human tissue plasminogen activator (rtPA)
19 Colchicine for Acute Coronary Syndromes Unknown status NCT01906749 Phase 4 Colchicine;Placebo
20 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
21 Cerebral Artery Stenosis, Coronary Artery Disease and Arrhythmia Unknown status NCT00247533 Phase 4
22 IV Double and Triple Concentrated Nicardipine for Stroke and ICH Unknown status NCT00325793 Phase 4 Nicardipine
23 The Efficacy and Safety Study of Dabigatran and Warfarin to Non-valvular Atrial Fibrillation Patients Unknown status NCT02646267 Phase 4 standard intensity warfarin;low intensity warfarin;dabigatran etexilate
24 Aliskiren or Amlodipine in Hypertensive Hemodialysed Patients Unknown status NCT01394770 Phase 4 Aliskiren
25 RAAS Inhibitor Drugs in Dialysis Patients Unknown status NCT01635387 Phase 4 aliskiren
26 Rivaroxaban in Patients With Atrial Fibrillation and Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Unknown status NCT02334254 Phase 4 rivaroxaban and ticagrel therapy;triple antithrombotic regimen with warfarin, asipirin and clopidogrel
27 Resuvastatin Treatment for Symptomatic Middle Cerebral Artery Stenosis Based on High-resolution Magnetic Resonance Imaging Unknown status NCT02041117 Phase 4 Rosuvastatin
28 Intensive Rosuvastatin Therapy on Cerebral Hemodynamics in Patients With Atherosclerotic Intracranial Arterial Stenosis Unknown status NCT02594800 Phase 4 Rosuvastatin
29 Triple Therapy in Patients on Oral Anticoagulation After Drug Eluting Stent Implantation Unknown status NCT00776633 Phase 4 aspirin;clopidogrel;oral anticoagulation
30 Multifactorial Intervention in Type 2 Diabetes - Italy Unknown status NCT01240070 Phase 4
31 Plasma and Platelet microRNAs in Clopidogrel Low Response Patients Unknown status NCT02447809 Phase 4 Clopidogrel;acetylsalicylic acid (ASA)
32 Optimal Anti-platelet Treatment for Patients With Clopidogrel Low Response Unknown status NCT01955200 Phase 4 Ticagrelor;Clopidogrel;Cilostazol;Clopidogrel;Clopidogrel
33 Acute Candesartan Cilexetil Outcomes Stroke Trial (ACCOST) Unknown status NCT00108706 Phase 4 Candesartan
34 The Effect of Dan-shen Extract On Lipoprotein Associated PHospholipase A2 Levels IN Patients With Stable Angina Pectoris Unknown status NCT02870764 Phase 4 Dan-shen extract;Placebo
35 Exploring Efficacy of Intensive Rosuvastatin Treatment Peri-PCI in Chinese Patients With Non ST-segment Elevated Acute Coronary Syndrome(NSTE-ACS) Unknown status NCT02284503 Phase 4 Rosuvastatin
36 Atrial Fibrillation and Ischemic Events With Rivaroxaban in Patients With Stable Coronary Artery Disease Study Unknown status NCT02642419 Phase 4 Rivaroxaban and single antiplatelet drug (aspirin, clopidogrel or prasugrel);Rivaroxaban
37 Anti-inflammatory Effects of Rivaroxaban Versus Dabigatran Unknown status NCT02331602 Phase 4 Rivaroxaban;Dabigatran
38 Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMI Unknown status NCT01158846 Phase 4 prasugrel/bivalirudin;clopidogrel/abciximab
39 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
40 Effects of Intranasal Nerve Growth Factor for Acute Ischemic Stroke Recruiting NCT03686163 Phase 4 Nerve Growth Factors;normal saline
41 Curative Efficacy of Secondary Prevention for Patients With Ischemic Stroke Through Syndrome Differentiation of TCM Completed NCT02334969 Phase 4 Naoxintong Capsule;Placebo
42 OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial Not yet recruiting NCT03759938 Phase 4 Direct oral anticoagulant (DOAC)
43 Effectiveness of Butylphthalide on Dynamic Cerebral Autoregulation in Patients With Acute Ischemic Stroke. Recruiting NCT03413202 Phase 4 butylphthalide(NBP);placebo
44 Xingnaojing for Moderate-to-severe Acute Ischemic Stroke (XMAS) Recruiting NCT02728180 Phase 4 Xingnaojing injection
45 Butyphthalide in Combination With Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke Recruiting NCT03394950 Phase 4 Butyphthalide combined with rtPA;rtPA
46 Argatroban Combined With Antiplatelet Versus Antiplatelet for Acute Ischemic Stroke Recruiting NCT03552354 Phase 4 Argatroban plus dual antiplatelet
47 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
48 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin，chinese herbs；
49 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
50 Tongxinluo Capsule in Ischemic Stroke Patients（TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule

Search NIH Clinical Center for Stroke, Ischemic

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Stroke, Ischemic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Stroke, Ischemic:
ALD-401, bone marrow-derived cells for stroke
Autologous bone marrow-derived mononuclear cells for treatment of acute ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Bone marrow-derived mononuclear cells for ischemic stroke
Cerecellgram-Stroke, bone marrow-derived mesenchymal stem cells for treatment of ischemic stroke
Embryonic stem cell-derived neural stem cells for ischemic stroke
Mesenchymal stem cells for ischemic stroke
MultiStem�, bone marrow-derived cells for ischemic and neonatal stroke
NSI-566, spinal cord stem cells for neurological disorders
Olfactory ensheathing cells transplantion for treatment of old stroke ischemic patients
PDA001, Placenta-derived cells for ischemic stroke
ReN001, human neural stem cells for the treatment of stroke
SB623, Notch1-transfected mesenchymal stem cells for stroke
Stemedyne�-MSC, mesenchymal stem cells for ischemic stroke
Umbilical cord blood-derived CD34+ stem cells for treatment of chronic ischemic stroke
Umbilical cord-derived mesenchymal stem cells for treatment of stroke
Embryonic/Adult Cultured Cells Related to Stroke, Ischemic:
Bone marrow-derived ALDH+ cells (ALD) PMIDs: 10430905
Bone marrow-derived mononuclear cells (family) PMIDs: 22960888
Bone marrow-derived mononuclear cells PMIDs: 17635049
Bone marrow-derived mononuclear cells PMIDs: 20629187 20395386
Bone marrow-derived mesenchymal stem cells (Cerecellgram-Stroke)
Neural stem cells PMIDs: 18286199
Bone marrow-derived mesenchymal stem cells (family)
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285
Fetal spinal cord stem cells (NSI-566) PMIDs: 22415942 19326469
Olfactory ensheathing cells
Placenta-derived cells
Neural stem cell line (CTX0E03) PMIDs: 19633272 23185625 17981710
Notch-transfected mesenchymal stromal cells (SB623) PMIDs: 19530164 23430693 20350349 21982515
Trophic factor-induced mesenchymal stem cells PMIDs: 19530164 23430693 20350349 21982515
Bone marrow-derived mesenchymal stem cells (Stemedyne�-MSC, itMSC) PMIDs: 23295150
Umbilical cord blood-derived hematopoietic stem cells (family)
Umbilical cord-derived mesenchymal stem cells

Cochrane evidence based reviews: cerebral infarction

Sources

Genetic Tests for Stroke, Ischemic

About this section

Genetic tests related to Stroke, Ischemic:

# Genetic test Affiliating Genes
1 Ischemic Stroke 29 ALOX5AP F2 F5 NOS3 PRKCH
2 Stroke 29
3 Stroke, Ischemic, Susceptibility to 29
Sources

Anatomical Context for Stroke, Ischemic

About this section

MalaCards organs/tissues related to Stroke, Ischemic:

41
Brain, Heart, Endothelial, Testes, Bone, Kidney, Spinal Cord
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Stroke, Ischemic:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate
2 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells
Sources

Publications for Stroke, Ischemic

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Articles related to Stroke, Ischemic:

(show top 50) (show all 1991)
# Title Authors Year
1
Hemorrhagic Transformation After Acute Ischemic Stroke in Atrial Fibrillation Patients. ( 30539757 )
2019
2
The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes. ( 30554496 )
2019
3
Strengthening nursing role and functions in stroke rehabilitation 24/7: A mixed-methods study assessing the feasibility and acceptability of an educational intervention programme. ( 30534406 )
2019
4
Predictors of Direct Enteral Tube Placement After Acute Stroke. ( 30539755 )
2019
5
Impact of Relative Blood Glucose Changes on Mortality Risk of Patient with Acute Ischemic Stroke and Treated with Mechanical Thrombectomy. ( 30539756 )
2019
6
Combining anti-inflammatory and unfolding protein responses to fight stroke. ( 30539812 )
2019
7
Association of G-protein coupled purinergic receptor P2Y2 with ischemic stroke in a Han Chinese population of North China. ( 30539820 )
2019
8
Edonerpic Maleate: A Promising Pharmacological Agent for Stroke Recovery. ( 30551191 )
2019
9
Neuroprotective agents in Acute Ischemic Stroke-A Reality Check. ( 30551514 )
2019
10
Council on Cardiovascular and Stroke Nursing Liaison Report. ( 30520853 )
2019
11
Diffusion kurtosis imaging of microstructural changes in brain tissue affected by acute ischemic stroke in different locations. ( 30531010 )
2019
12
Neuronal autophagy aggravates microglial inflammatory injury by downregulating CX3CL1/fractalkine after ischemic stroke. ( 30531011 )
2019
13
Cerebral ischemic stroke: cellular fate and therapeutic opportunities. ( 30468665 )
2019
14
Stroke in Pregnancy: An Update. ( 30470272 )
2019
15
Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke. ( 30472160 )
2019
16
System-integrated technology-enabled model of care to improve the health of stroke patients in rural China: protocol for SINEMA-a cluster-randomized controlled trial. ( 30408621 )
2019
17
An international cluster-randomized quality improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE Trial. ( 30415083 )
2019
18
Blood pressure differences between home monitoring and daytime ambulatory values and their reproducibility in treated hypertensive stroke and TIA patients. ( 30415084 )
2019
19
Positioning the six-month review in the recovery process post-stroke: The ideology of personal responsibility. ( 30375706 )
2019
20
Hyperforin improves post-stroke social isolation‑induced exaggeration of PSD and PSA via TGF-β. ( 30387813 )
2019
21
High serum nerve growth factor concentrations are associated with good functional outcome at 3 months following acute ischemic stroke. ( 30393197 )
2019
22
Cerebral infarction following cyanoacrylate endoscopic therapy of duodenal varices in a patient with a patent foramen ovale. ( 29948836 )
2018
23
Large pulmonary arteriovenous malformation with paradoxical cerebral infarction. ( 29534345 )
2018
24
Pulmonary arteriovenous fistula complicated by venous thromboembolism and paradoxical cerebral infarction during early pregnancy. ( 29437680 )
2018
25
Stroke, Ischemic ( 29763173 )
2018
26
Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect. ( 29636612 )
2018
27
Acquired hemophilia A developing cerebral infarction 36 days after the frequent administration of bypass hemostatic agents. ( 30283617 )
2018
28
The Dipyridamole Added to Dual Antiplatelet Therapy in Cerebral Infarction After First Acute Myocardial Infarction: A Nationwide, Case-Control Study. ( 30538667 )
2018
29
Cerebral infarction associated with benign mucin-producing adenomyosis: report of two cases. ( 30286732 )
2018
30
Nonbacterial Thrombotic Endocarditis Complicated by Cerebral Infarction in a Patient with Adenomyosis with High Serum CA125 Level; A Case Report. ( 29102541 )
2018
31
How do aging and comorbidities impact risk of ischemic stroke in patients with atrial fibrillation. ( 30446380 )
2018
32
Antiepileptic Drug Use and the Risk of Stroke Among Community-Dwelling People With Alzheimer Disease: A Matched Cohort Study. ( 30371186 )
2018
33
Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris. ( 30371177 )
2018
34
Antiphospholipid Syndrome With Isolated Isotype M Anticardiolipin and/or Anti-B2GPI Antibody Is Associated With Stroke. ( 30355196 )
2018
35
Association Between Anxiety, Depression, and Post-traumatic Stress Disorder and Outcomes After Ischemic Stroke. ( 30450075 )
2018
36
SIRT1: The Value of Functional Outcome, Stroke-Related Dementia, Anxiety, and Depression in Patients with Acute Ischemic Stroke. ( 30361109 )
2018
37
Impairments in the Comprehension of Indoor Object/Body Part Words and Family Relationships in a Patient with Aphasia due to Cerebral Infarction of the Left Parietal and Temporal Lobes. ( 30140218 )
2018
38
Relative contributions of lesion location and lesion size to predictions of varied language deficits in post-stroke aphasia. ( 30380520 )
2018
39
Robotic Arm Rehabilitation in Chronic Stroke Patients With Aphasia May Promote Speech and Language Recovery (but Effect Is Not Enhanced by Supplementary tDCS). ( 30405512 )
2018
40
Efficacy of a self-administered treatment using a smart tablet to improve functional vocabulary in post-stroke aphasia: a case-series study. ( 30426650 )
2018
41
Psychometric properties of the Chinese-version Stroke and Aphasia Quality of Life Scale 39-generic version (SAQOL-39g). ( 30451594 )
2018
42
Crossed aphasia following cerebral infarction in a right-handed patient with atypical cerebral language dominance. ( 29777360 )
2018
43
A case of symmetric retrograde thromboembolic cerebral infarction in an 8-year-old child due to arterial thoracic outlet syndrome. ( 30019112 )
2018
44
Pearls & Oy-sters: Neuro-Sweet disease presenting as ischemic stroke and aseptic meningitis. ( 30510029 )
2018
45
Clinical significance and efficacy analysis of atorvastatin in the treatment of patients with cerebral infarction and aspiration pneumonia. ( 30542469 )
2018
46
Dysphagia and aspiration pneumonia in elderly hospitalization stroke patients: Risk factors, cerebral infarction area comparison. ( 30223382 )
2018
47
Impact of dronedarone on the risk of myocardial infarction and stroke in atrial fibrillation patients followed in general practices in Germany. ( 30528621 )
2018
48
Development and validation of a score to detect paroxysmal atrial fibrillation after stroke. ( 30530796 )
2018
49
Mean Platelet Volume in Patients with Acute Ischemic Stroke with Nonvalvular Atrial Fibrillation. ( 30549988 )
2018
50
A New Model to Predict Ischemic Stroke in Patients with Atrial Fibrillation Using Warfarin or Direct Oral Anticoagulants. ( 30550837 )
2018