MCID: STR086
MIFTS: 23

Stromal Dystrophy

Categories: Eye diseases

Aliases & Classifications for Stromal Dystrophy

MalaCards integrated aliases for Stromal Dystrophy:

Name: Stromal Dystrophy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060442

Summaries for Stromal Dystrophy

Disease Ontology : 12 A corneal dystrophy that affects the corneal stroma.

MalaCards based summary : Stromal Dystrophy is related to schnyder corneal dystrophy and corneal dystrophy, congenital stromal. An important gene associated with Stromal Dystrophy is DCN (Decorin), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Diseases of glycosylation. Affiliated tissues include eye, endothelial and skin.

Related Diseases for Stromal Dystrophy

Graphical network of the top 20 diseases related to Stromal Dystrophy:



Diseases related to Stromal Dystrophy

Symptoms & Phenotypes for Stromal Dystrophy

Drugs & Therapeutics for Stromal Dystrophy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observational Study of Corneal Opacities in Adults Recruiting NCT02109471

Search NIH Clinical Center for Stromal Dystrophy

Genetic Tests for Stromal Dystrophy

Anatomical Context for Stromal Dystrophy

MalaCards organs/tissues related to Stromal Dystrophy:

41
Eye, Endothelial, Skin

Publications for Stromal Dystrophy

Articles related to Stromal Dystrophy:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Corneal biomechanics and intraocular pressure assessment after penetrating keratoplasty for non keratoconic patients, long term results. 38
31391006 2019
2
Recurrent corneal erosion: a comprehensive review. 38
30809089 2019
3
Macular corneal dystrophy: A review. 38
29604391 2018
4
Long-term clinical outcome of femtosecond laser-assisted lamellar keratectomy with phototherapeutic keratectomy in anterior corneal stromal dystrophy. 38
28611133 2018
5
Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders. 38
28346368 2017
6
In vivo confocal microscopy of pre-Descemet corneal dystrophy associated with X-linked ichthyosis: a case report. 38
28302098 2017
7
Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. 38
28234994 2017
8
Bilateral cloudy cornea: is the usual suspect congenital hereditary endothelial dystrophy or stromal dystrophy? 38
27107055 2016
9
Keratoconus in Patients with Macular Stromal Dystrophy. 38
27455826 2016
10
Changing indications and techniques for corneal transplantations at a tertiary referral center in Turkey, from 1995 to 2014. 38
27330270 2016
11
Prevalence and histopathological characteristics of corneal stromal dystrophies in Saudi Arabia. 38
25949075 2015
12
Granular corneal dystrophy: a novel approach to classification and treatment. 38
24413275 2014
13
Graft survival and visual outcome after simultaneous penetrating keratoplasty and cataract extraction. 38
23826538 2013
14
A novel decorin gene mutation in congenital hereditary stromal dystrophy: a Korean family. 38
22870031 2012
15
Outcomes of deep anterior lamellar keratoplasty following successful and failed 'big bubble'. 38
22133987 2012
16
Fibrillin-2, tenascin-C, matrilin-2, and matrilin-4 are strongly expressed in the epithelium of human granular and lattice type I corneal dystrophies. 38
22876117 2012
17
A novel mutation of the decorin gene identified in a Korean family with congenital hereditary stromal dystrophy. 38
21993463 2011
18
[Perspectives of deep anterior lamellar keratoplasty]. 38
21909871 2011
19
Decorin biology, expression, function and therapy in the cornea. 38
21342131 2011
20
TGFBI mutational analysis in a New Zealand population of inherited corneal dystrophy patients. 38
19948560 2010
21
Outcome of primary adult optical penetrating keratoplasty with imported donor corneas. 38
19165422 2010
22
Major shifts in corneal transplantation procedures in north China: 5316 eyes over 12 years. 38
19556213 2009
23
Outcome of primary adult penetrating keratoplasty in a Saudi Arabian population. 38
19654527 2009
24
Postoperative complications after primary adult optical penetrating keratoplasty: prevalence and impact on graft survival. 38
19411956 2009
25
Corneal crystalline stromal dystrophy and lipidic metabolism in the dog. 38
18685968 2008
26
Staged automated lamellar keratoplasty for anterior stromal corneal dystrophies. 38
18556939 2008
27
Suppression of keratoepithelin and myocilin by small interfering RNAs (siRNA) in vitro. 38
18079684 2007
28
Congenital corneal opacities: a review with a focus on genetics. 38
18097987 2007
29
Histopathologic study of corneal stromal dystrophies: a 10-year experience. 38
17893527 2007
30
[Femtosecond-assisted anterior lamellar keratoplasty]. 38
17878821 2007
31
Suppression of keratoepithelin and myocilin by small interfering RNA (an American Ophthalmological Society thesis). 38
18427622 2007
32
Deep Anterior Lamellar Keratoplasty (DALK): visual outcome and complications for a heterogeneous group of corneal pathologies. 38
17198015 2007
33
Repeat penetrating keratoplasty: indications, graft survival, and visual outcome. 38
16488955 2006
34
Influence of interleukin-1alpha and tumor necrosis factor-alpha production on corneal graft survival. 38
16489698 2006
35
Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. 38
15671264 2005
36
Risk factors for corneal regraft in patients on the French waiting list. 38
15448497 2004
37
Central discoid corneal dystrophy. 38
12410027 2002
38
[Ocular Manifestation of Mucopolysaccharidosis I-S (Scheie's Syndrome)]. 38
12447720 2002
39
Corneal electrolysis for recurrence of corneal stromal dystrophy after keratoplasty. 38
11864880 2002
40
Ocular lipid deposition and hyperlipoproteinaemia. 38
12062534 2002
41
Report of a new family with dominant congenital heredity stromal dystrophy of the cornea. 38
11805522 2002
42
Profile of cytokines in aqueous humor from corneal graft recipients. 38
11740849 2001
43
[Autosomal dominant inherited corneal dystrophies associated with TGFBI mutation]. 38
11692612 2001
44
Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. 38
11438047 2001
45
Annular granular corneal opacity: a rare corneal stromal dystrophy or degeneration? 38
11202916 2000
46
Association of autosomal dominantly inherited corneal dystrophies with BIGH3 gene mutations in Japan. 38
11024425 2000
47
Keratocyte apoptosis associated with keratoconus. 38
10548467 1999
48
Confocal microscopy in Bowman and stromal corneal dystrophies. 38
10485537 1999
49
[Photo-therapeutic keratectomy (PTK)--a successful treatment for Thiel-Behnke dystrophy and its recurrence]. 38
10509078 1999
50
[Lattice corneal dystrophy. Detection of a point mutation in the kerato-epithelin gene]. 38
10429500 1999

Variations for Stromal Dystrophy

Expression for Stromal Dystrophy

Search GEO for disease gene expression data for Stromal Dystrophy.

Pathways for Stromal Dystrophy

GO Terms for Stromal Dystrophy

Cellular components related to Stromal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.43 TGFBI LUM DCN
2 Golgi lumen GO:0005796 9.33 LUM KERA DCN
3 extracellular matrix GO:0031012 9.26 TGFBI LUM KERA DCN
4 lysosomal lumen GO:0043202 8.8 LUM KERA DCN

Biological processes related to Stromal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.43 TGFBI LUM DCN
2 visual perception GO:0007601 9.33 TGFBI LUM KERA
3 keratan sulfate catabolic process GO:0042340 8.96 LUM KERA
4 keratan sulfate biosynthetic process GO:0018146 8.8 LUM KERA CHST6

Molecular functions related to Stromal Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.26 TGFBI DCN
2 glycosaminoglycan binding GO:0005539 9.16 EPYC DCN
3 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.96 LUM DCN
4 collagen binding GO:0005518 8.8 TGFBI LUM DCN

Sources for Stromal Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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