MCID: STR072
MIFTS: 51

Stromal Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Stromal Keratitis

MalaCards integrated aliases for Stromal Keratitis:

Name: Stromal Keratitis 59 73

Characteristics:

Orphanet epidemiological data:

59
stromal keratitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA137599
UMLS via Orphanet 74 C1318020
ICD10 via Orphanet 34 H16.3
UMLS 73 C1318020

Summaries for Stromal Keratitis

MalaCards based summary : Stromal Keratitis is related to uveitis and lyme disease. An important gene associated with Stromal Keratitis is PAX6 (Paired Box 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Acyclovir and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are blindness and keratitis

Related Diseases for Stromal Keratitis

Diseases related to Stromal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 uveitis 30.1 CCL2 CXCL10 IL17A IL2RA TNF
2 lyme disease 30.0 IL17A IL6 TNF
3 anterior uveitis 30.0 IL2RA IL6 TNF
4 scleritis 29.9 CCL2 TNF
5 viral infectious disease 29.8 CCL3 CXCL10 IL6 TNF
6 arthritis 29.8 CCL2 CIITA IL17A IL6 TNF
7 keratitis, hereditary 11.6
8 herpes simplex 10.7
9 staphylococcal toxic shock syndrome 10.3 CIITA TNF
10 scorpion envenomation 10.2 IL6 TNF
11 leukomalacia 10.2 IL6 TNF
12 trichosporonosis 10.2 IL17A TNF
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL6 TNF
14 autoimmune uveitis 10.2 CCL2 IL17A TNF
15 rheumatoid lung disease 10.2 IL17A TNF
16 critical limb ischemia 10.2 IL6 TNF
17 streptococcal toxic-shock syndrome 10.2 IL6 TNF
18 central nervous system vasculitis 10.2 IL17A IL6 TNF
19 diabetic foot ulcers 10.2 CCL2 IL6
20 ileocolitis 10.2 IL2RA TNF
21 autoimmune disease of eyes, ear, nose and throat 10.2 IL17A IL6 TNF
22 transverse myelitis 10.2 IL17A IL6 TNF
23 myelitis 10.2 IL17A IL6 TNF
24 juvenile ankylosing spondylitis 10.2 IL6 TNF
25 mycoplasma pneumoniae pneumonia 10.2 IL17A IL6 TNF
26 joint disorders 10.2 IL17A IL6 TNF
27 ileitis 10.2 IL17A IL6 TNF
28 ischemic heart disease 10.2 CCL2 IL6 TNF
29 cardiogenic shock 10.2 IL6 TNF
30 echinococcosis 10.2 IL17A IL6 TNF
31 radiculopathy 10.2 CCL2 IL17A IL6
32 bronchiolitis obliterans 10.2 IL17A IL6 TNF
33 dengue shock syndrome 10.2 CCL2 IL6 TNF
34 spondyloarthropathy 10.2 IL17A IL6 TNF
35 complex regional pain syndrome 10.2 CCL2 IL6 TNF
36 opportunistic mycosis 10.2 IL17A IL17RA TNF
37 chikungunya 10.2 CCL2 IL6 TNF
38 autoimmune disease of musculoskeletal system 10.2 IL17A IL6 TNF
39 pyelonephritis 10.2 CCL2 IL6 TNF
40 leptospirosis 10.2 CCL2 IL6 TNF
41 temporal arteritis 10.2 CCL2 IL6 TNF
42 pulmonary sarcoidosis 10.2 CCL2 IL2RA TNF
43 upper respiratory tract disease 10.2 IL17A IL6 TNF
44 bronchial disease 10.2 IL17A IL6 TNF
45 intermediate uveitis 10.2 IL2RA IL6 TNF
46 spondylitis 10.2 IL17A IL6 TNF
47 posterior uveitis 10.2 IL2RA IL6 TNF
48 pneumoconiosis 10.2 CCL2 IL6 TNF
49 chorioamnionitis 10.1 CCL2 IL6 TNF
50 toxic shock syndrome 10.1 CIITA IL6 TNF

Graphical network of the top 20 diseases related to Stromal Keratitis:



Diseases related to Stromal Keratitis

Symptoms & Phenotypes for Stromal Keratitis

Human phenotypes related to Stromal Keratitis:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 blindness 59 32 occasional (7.5%) Occasional (29-5%) HP:0000618
2 keratitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000491
3 deep anterior chamber 59 32 hallmark (90%) Very frequent (99-80%) HP:0007765
4 corneal stromal edema 59 32 hallmark (90%) Very frequent (99-80%) HP:0012040
5 herpetiform corneal ulceration 59 32 frequent (33%) Frequent (79-30%) HP:0007812
6 descemet membrane folds 59 32 frequent (33%) Frequent (79-30%) HP:0012039
7 decreased corneal sensation 59 32 frequent (33%) Frequent (79-30%) HP:0012155
8 corneal perforation 59 32 frequent (33%) Frequent (79-30%) HP:0100583
9 reduced visual acuity 59 Very frequent (99-80%)
10 primary open angle glaucoma 59 Very frequent (99-80%)
11 increased lacrimation 59 Frequent (79-30%)
12 epiphora 32 frequent (33%) HP:0009926
13 open angle glaucoma 32 hallmark (90%) HP:0012108

GenomeRNAi Phenotypes related to Stromal Keratitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CCL2 CCL20 CCL3 CCR6 CD69 IL17A

MGI Mouse Phenotypes related to Stromal Keratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 CCR6 CD69 CIITA CXCL10 IL17A IL17RA
2 homeostasis/metabolism MP:0005376 9.7 AIMP1 CCR6 CIITA CXCL10 IL17A IL17RA
3 immune system MP:0005387 9.47 AIMP1 CCL2 CCR6 CD69 CIITA CXCL10

Drugs & Therapeutics for Stromal Keratitis

Drugs for Stromal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acyclovir Approved Phase 4,Phase 3 59277-89-3 2022
2
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
6
Difluprednate Approved Phase 4 23674-86-4 443936
7
Prednisolone hemisuccinate Experimental Phase 4,Phase 3 2920-86-7
8 Anti-Infective Agents Phase 4,Phase 3
9 Antiviral Agents Phase 4,Phase 3
10 Prednisolone acetate Phase 4,Phase 3
11 Methylprednisolone acetate Phase 4,Phase 3
12 valacyclovir Phase 4
13 Ophthalmic Solutions Phase 4
14 Protective Agents Phase 3
15 Autonomic Agents Phase 3
16 Gastrointestinal Agents Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Hormones Phase 3
19 Neuroprotective Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Zoster Eye Disease Study Recruiting NCT03134196 Phase 4 Masked Placebo;Masked Oral Valacyclovir
2 A Randomized Trial of Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) Keratitis Not yet recruiting NCT03626376 Phase 4 oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily;oral acyclovir 400 mg BID OR valacyclovir 500 mg qdaily + topical corticosteroid eye drops
3 Herpetic Eye Disease Study (HEDS) I Unknown status NCT00000138 Phase 3 Prednisolone Phosphate;Acyclovir
4 Herpetic Eye Disease Study (HEDS) II Completed NCT00000139 Phase 3 Acyclovir

Search NIH Clinical Center for Stromal Keratitis

Genetic Tests for Stromal Keratitis

Anatomical Context for Stromal Keratitis

MalaCards organs/tissues related to Stromal Keratitis:

41
Eye, T Cells, Endothelial, Neutrophil, Lung, Bone, Heart

Publications for Stromal Keratitis

Articles related to Stromal Keratitis:

(show top 50) (show all 238)
# Title Authors Year
1
Immune stromal keratitis: a rare ocular presentation of tuberculosis. ( 29622703 )
2018
2
Stromal Keratitis with Endophthalmitis Caused by Vittaforma Corneae in an Immunocompetent Patient: A Case Report. ( 29672246 )
2018
3
Application of our understanding of pathogenesis of herpetic stromal keratitis for novel therapy. ( 29329934 )
2018
4
Reactivation of Herpes Zoster Stromal Keratitis After HZ/su Adjuvanted Herpes Zoster Subunit Vaccine. ( 30318037 )
2018
5
Development of Inflammatory Hypoxia and Prevalence of Glycolytic Metabolism in Progressing Herpes Stromal Keratitis Lesions. ( 30530484 )
2018
6
Topical cyclosporine-A versus prednisolone for herpetic stromal keratitis: a randomized controlled trial. ( 30284385 )
2018
7
An unusual occurrence of stromal keratitis in dengue fever. ( 30355887 )
2018
8
CXCL9 compensates for the absence of CXCL10 during recurrent Herpetic stromal keratitis. ( 28282568 )
2017
9
Azacytidine Treatment Inhibits the Progression of Herpes Stromal Keratitis by Enhancing Regulatory T Cell Function. ( 28100624 )
2017
10
Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis. ( 29296556 )
2017
11
Delayed onset of pressure-induced interlamellar stromal keratitis in a patient with recurrent uveitis: A case report. ( 29310395 )
2017
12
Coexistence of herpes simplex virus infection in microsporidial stromal keratitis associated with granulomatous inflammation. ( 28513490 )
2017
13
Potential Clue to the Pathogenesis of Varicella-Zoster Virus Stromal Keratitis. ( 28799957 )
2017
14
Stromal keratitis in a neonate: Herpes virus a diagnosis to consider. ( 26710660 )
2016
15
Targeting Autophagy in Dendritic Cells as a Mechanism to Limit Immunopathogenesis in Herpetic Stromal Keratitis. ( 26758184 )
2016
16
Amniotic membrane transplantation in bacterial and herpetic stromal keratitis. ( 27511511 )
2016
17
Management of Neonatal Herpes Simplex Infection: A Rare Case of Blepharoconjunctivitis and Concurrent Epithelial and Stromal Keratitis. ( 27849421 )
2016
18
A Central Role for Sympathetic Nerves in Herpes Stromal Keratitis in Mice. ( 27070108 )
2016
19
Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis. ( 27798158 )
2016
20
Painful Acute Corneal Ulceration and Anterior Stromal Keratitis in an Adolescent With Reactive Arthritis. ( 27977029 )
2016
21
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient. ( 27528053 )
2016
22
Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole. ( 28123915 )
2016
23
LASIK Interface Complications: Pressure-induced Stromal Keratitis (PISK), Interface Fluid Syndrome (IFS) and Post-LASIK Edema-induced Keratopathy (PLEK). ( 27257731 )
2016
24
Microsporidial Stromal Keratitis: Clinical Features, Unique Diagnostic Criteria, and Treatment Outcomes in a Large Case Series. ( 27467044 )
2016
25
Herpetic Stromal Keratitis following Selective Laser Trabeculoplasty. ( 26989540 )
2016
26
Real-time polymerase chain reaction for the diagnosis of necrotizing herpes stromal keratitis. ( 27275421 )
2016
27
Clinical evaluation of deep anterior lamellar keratoplasty using glycerol-cryopreserved corneal tissues for refractory herpetic stromal keratitis: An observational study. ( 27684823 )
2016
28
Do Unilateral Herpetic Stromal Keratitis and Neurotrophic Ulcers Cause Bilateral Dry Eye? ( 25933398 )
2015
29
Idiopathic stromal keratitis resembling central toxic keratopathy. ( 26210054 )
2015
30
Prevention of herpes simplex virus induced stromal keratitis by a glycoprotein B-specific monoclonal antibody. ( 25587898 )
2015
31
Large Amounts of Reactivated Virus in Tears Precedes Recurrent Herpes Stromal Keratitis in Stressed Rabbits Latently Infected with Herpes Simplex Virus. ( 25859798 )
2015
32
Confocal Microscopic Analysis of a Rabbit Eye Model of High-Incidence Recurrent Herpes Stromal Keratitis. ( 26555580 )
2015
33
Impaired Fas-Fas Ligand Interactions Result in Greater Recurrent Herpetic Stromal Keratitis in Mice. ( 26504854 )
2015
34
Therapeutic Use of Soluble Fas Ligand Ameliorates Acute and Recurrent Herpetic Stromal Keratitis in Mice. ( 26444718 )
2015
35
Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. ( 26590045 )
2015
36
Evaluation of Effect of Topical Tacrolimus Treatment on Herpetic Stromal Keratitis in a Rat Model. ( 25996419 )
2015
37
IL-2/anti-IL-2 antibody complex treatment inhibits the development but not the progression of herpetic stromal keratitis. ( 25411200 )
2015
38
Robo 4 Counteracts Angiogenesis in Herpetic Stromal Keratitis. ( 26720197 )
2015
39
Role of miR-155 in the Pathogenesis of Herpetic Stromal Keratitis. ( 25700796 )
2015
40
Dendritic Cell Autophagy Contributes to Herpes Simplex Virus-Driven Stromal Keratitis and Immunopathology. ( 26507231 )
2015
41
Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis. ( 26342658 )
2015
42
Microsporidial stromal keratitis masquerading as acute graft rejection. ( 25533000 )
2015
43
Conjunctival flap covering combined with antiviral and steroid therapy for severe herpes simplex virus necrotizing stromal keratitis. ( 25785282 )
2015
44
Femtosecond laser-assisted anterior lamellar keratoplasty in stromal keratitis caused by an Endoreticulatus-like microsporidia. ( 25826328 )
2015
45
Corneal lymphangiogenesis in herpetic stromal keratitis. ( 25444520 )
2015
46
A young immunocompetent patient with bilateral immune stromal keratitis due to varicella zoster and herpes simplex. ( 24985896 )
2014
47
Reversible nerve damage and corneal pathology in murine herpes simplex stromal keratitis. ( 24789786 )
2014
48
Correlation between matrix metalloproteinase expression and activation of the focal adhesion kinase signaling pathway in herpes stromal keratitis. ( 24348806 )
2014
49
CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. ( 24442436 )
2014
50
Herpes zoster stromal keratitis after varicella vaccine booster in a pediatric patient. ( 25062334 )
2014

Variations for Stromal Keratitis

Expression for Stromal Keratitis

Search GEO for disease gene expression data for Stromal Keratitis.

Pathways for Stromal Keratitis

Pathways related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CCL2 CCL20 CCL3 CCR6 CIITA CXCL10
2
Show member pathways
13.8 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
3
Show member pathways
13.61 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
4
Show member pathways
13.32 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
5
Show member pathways
13.17 CCL2 CCL20 CCL3 CCR6 CXCL10 IL17A
6
Show member pathways
13.14 CCL2 CCL20 CCL3 CIITA CXCL10 IL17A
7
Show member pathways
12.86 CIITA IL17A IL2RA IL6 TNF TRB
8
Show member pathways
12.82 CCL2 CCL20 CCL3 CCR6 CXCL10
9
Show member pathways
12.77 CCL2 CIITA CXCL10 IL2RA IL6 TNF
10
Show member pathways
12.59 IL17A IL1RAP IL2RA IL6 TNF TRB
11
Show member pathways
12.52 CCL2 IL17A IL6 TNF
12 12.52 CCL2 CIITA CXCL10 IL17A IL2RA TNF
13
Show member pathways
12.37 IL17A IL6 TNF TRB
14
Show member pathways
12.28 CCL2 CCL20 CXCL10 IL17A IL17RA IL6
15
Show member pathways
12.17 CCL2 CCL20 CCL3 CCR6 CXCL10
16
Show member pathways
12.17 CCL20 CXCL10 IL1RAP IL6 TNF
17
Show member pathways
12.08 CCL2 CCL20 CCL3 IL17A IL2RA IL6
18
Show member pathways
12.05 IL17A IL1RAP IL6 TNF
19 12.01 CCL2 CXCL10 IL6 TNF
20
Show member pathways
12 CCL2 CCL20 CCL3 CCR6 CXCL10
21 11.99 CD69 IL2RA IL6 TNF
22 11.97 CCL2 IL17A IL6 TNF
23 11.96 CCL2 CCL20 CXCL10 IL6 TNF
24
Show member pathways
11.91 CCL3 IL2RA TRB
25 11.85 CCL2 IL6 TNF
26 11.84 IL2RA IL6 TNF
27
Show member pathways
11.82 IL17A IL17RA IL6
28 11.81 CCL3 CCR6 IL17A IL2RA TNF
29 11.75 CCL2 CCL20 CCL3 IL17A IL6 TNF
30 11.7 IL17RA IL6 TNF
31 11.68 CCL2 CCL3 IL6 TNF
32 11.56 IL1RAP TNF TRB
33 11.52 CCL2 IL6 TNF
34 11.49 IL2RA IL6 TNFSF4
35 11.32 CCL2 CCL20 CCL3 CXCL10 IL6 TNF
36 11.31 IL17A IL6 TNF
37 11.26 IL6 TNF TRB
38 11.02 CCL2 CCL20 CCL3 CXCL10 IL17A IL6
39 10.98 CCL2 CCL3 TNF
40 10.98 CCL2 CCL20 CCL3 CXCL10 IL17A IL6
41 10.79 CCL2 CCL20 CCL3 CXCL10 IL17A IL6

GO Terms for Stromal Keratitis

Cellular components related to Stromal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.92 CCL2 CCL20 CCL3 CCR6 CXCL10 IL2RA
2 cell surface GO:0009986 9.8 AIMP1 CCR6 CD69 CIITA IL2RA TNF
3 extracellular space GO:0005615 9.65 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A
4 external side of plasma membrane GO:0009897 9.63 CCR6 CD69 CXCL10 IL17A IL2RA TNF
5 extracellular region GO:0005576 9.36 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A

Biological processes related to Stromal Keratitis according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.97 CCL2 CXCL10 IL17RA IL2RA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 CCL2 CCL20 CCL3 TNF
3 MAPK cascade GO:0000165 9.95 CCL2 CCL3 IL2RA TNF
4 cell-cell signaling GO:0007267 9.93 AIMP1 CCL20 CCL3 CXCL10 IL17A
5 regulation of signaling receptor activity GO:0010469 9.91 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A
6 cellular response to lipopolysaccharide GO:0071222 9.88 CCL2 CXCL10 IL6 TNF TNFSF4
7 animal organ morphogenesis GO:0009887 9.87 CCL2 PAX6 TNF
8 response to virus GO:0009615 9.86 CXCL10 TNF TNFSF4
9 cellular response to interferon-gamma GO:0071346 9.85 CCL2 CCL20 CCL3 CIITA
10 neutrophil chemotaxis GO:0030593 9.83 CCL2 CCL20 CCL3 CXCL10
11 cellular response to organic cyclic compound GO:0071407 9.82 CCL2 CCL3 TNF
12 cellular response to interleukin-1 GO:0071347 9.81 CCL2 CCL20 CCL3 IL17A
13 cytokine-mediated signaling pathway GO:0019221 9.81 CCL2 CCL20 CCL3 CXCL10 IL17A IL1RAP
14 positive regulation of interleukin-6 production GO:0032755 9.8 IL6 TNF TNFSF4
15 positive regulation of inflammatory response GO:0050729 9.8 CCL3 IL17RA TNF TNFSF4
16 cell chemotaxis GO:0060326 9.8 CCL2 CCL20 CCL3 CCR6 CXCL10
17 chemotaxis GO:0006935 9.8 AIMP1 CCL2 CCL20 CCL3 CCR6 CXCL10
18 protein kinase B signaling GO:0043491 9.77 CCL2 CCL3 TNF
19 chemokine-mediated signaling pathway GO:0070098 9.77 CCL2 CCL20 CCL3 CCR6 CXCL10
20 lipopolysaccharide-mediated signaling pathway GO:0031663 9.76 CCL2 CCL3 TNF
21 humoral immune response GO:0006959 9.76 CCL2 CCR6 IL6 TNF
22 lymphocyte chemotaxis GO:0048247 9.75 CCL2 CCL20 CCL3
23 negative regulation of neurogenesis GO:0050768 9.73 IL6 PAX6 TNF
24 monocyte chemotaxis GO:0002548 9.73 CCL2 CCL20 CCL3 IL6
25 inflammatory response GO:0006954 9.7 AIMP1 CCL2 CCL20 CCL3 CIITA CXCL10
26 negative regulation of collagen biosynthetic process GO:0032966 9.69 CIITA IL6
27 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.69 IL17A IL17RA
28 positive regulation of glial cell proliferation GO:0060252 9.68 IL6 TNF
29 positive regulation of calcium ion import GO:0090280 9.68 CCL2 CCL3
30 positive regulation of T cell migration GO:2000406 9.68 CCL20 CXCL10
31 macrophage chemotaxis GO:0048246 9.67 CCL2 CCL3
32 positive regulation of immunoglobulin secretion GO:0051024 9.67 IL6 TNFSF4
33 T cell chemotaxis GO:0010818 9.66 CCL3 CXCL10
34 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
35 positive regulation of interleukin-13 production GO:0032736 9.65 IL1RAP TNFSF4
36 interleukin-17-mediated signaling pathway GO:0097400 9.64 IL17A IL17RA
37 T cell migration GO:0072678 9.63 CCL20 CCR6
38 astrocyte cell migration GO:0043615 9.62 CCL2 CCL3
39 positive regulation of neuroinflammatory response GO:0150078 9.62 IL6 TNF
40 granulocyte chemotaxis GO:0071621 9.61 CCL3 IL17RA
41 positive regulation of interleukin-23 production GO:0032747 9.61 IL17A IL17RA
42 fibroblast activation GO:0072537 9.59 IL17A IL17RA
43 thymocyte migration GO:0072679 9.57 CCL20 CCR6
44 immune response GO:0006955 9.4 CCL2 CCL20 CCL3 CCR6 CIITA CXCL10

Molecular functions related to Stromal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.65 CCL2 CXCL10 IL17RA LCN1 TNFSF4
2 CCR chemokine receptor binding GO:0048020 9.33 CCL2 CCL20 CCL3
3 cytokine activity GO:0005125 9.28 AIMP1 CCL2 CCL20 CCL3 CXCL10 IL17A
4 chemokine activity GO:0008009 9.26 CCL2 CCL20 CCL3 CXCL10

Sources for Stromal Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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