MCID: STR008
MIFTS: 54

Strongyloidiasis

Categories: Rare diseases, Infectious diseases, Gastrointestinal diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 76 53 59 55 3 44 15 73
Disseminated Strongyloidiasis 12 73
Anguilluliasis 59 73
Infection by Strongyloides 12
Threadworm Infection 53
Anguillulosis 59
Enterobiasis 73

Characteristics:

Orphanet epidemiological data:

59
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD10 33 B78 B78.9 B78.7
ICD9CM 35 127.2
MeSH 44 D013322
Orphanet 59 ORPHA76
MESH via Orphanet 45 D013322
ICD10 via Orphanet 34 B78.0 B78.9 B78.1 more
UMLS via Orphanet 74 C0038463 C0085810

Summaries for Strongyloidiasis

NIH Rare Diseases : 53 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin. Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to enterobiasis and paragonimiasis, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are hematopoietic system and immune system

CDC : 3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

Wikipedia : 76 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 enterobiasis 30.2 IL13 IL5
2 paragonimiasis 30.2 IL13 IL5
3 intestinal schistosomiasis 30.1 IL13 IL5
4 cryptosporidiosis 30.1 CCL11 CD79A
5 giardiasis 30.0 CD79A TGFB1
6 filariasis 29.8 IFNG IL5
7 pneumonia 29.7 CCL11 IL13 IL5
8 bronchitis 29.6 CCL11 CD79A IL5
9 reactive arthritis 29.6 CD79A IFNG
10 folliculitis 29.4 CCL11 IFNG IL5
11 schistosomiasis 29.4 CD79A IFNG IL13 IL5
12 pulmonary disease, chronic obstructive 29.0 CCL11 IL13 TGFB1
13 dermatitis 28.6 CCL11 IFNG IL13 IL5
14 inflammatory bowel disease 27.5 CCL11 IFNG IL13 IL5 TGFB1
15 asthma 27.2 CCL11 CD79A IFNG IL13 IL5 TGFB1
16 cow milk allergy 10.6 CD79A IL5
17 pemphigoid gestationis 10.6 CCL11 IL5
18 chronic meningitis 10.6 CCL11 IL5
19 cytokine deficiency 10.6 IL13 IL5
20 eosinophilic gastroenteritis 10.6 CCL11 IL5
21 primary amebic meningoencephalitis 10.6 CD79A IL5
22 chronic eosinophilic pneumonia 10.6 CCL11 IL5
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL13 IL5
24 respiratory syncytial virus infectious disease 10.6 IL13 IL5
25 kimura disease 10.6 CCL11 IL5
26 anterior scleritis 10.5 CD79A IL5
27 inflammatory bowel disease 4 10.5 IL13 IL5
28 apple allergy 10.5 IL13 IL5
29 ascaris lumbricoides infection 10.5 IL13 IL5
30 latex allergy 10.5 IL13 IL5
31 eosinophilic fasciitis 10.5 IFNG IL5
32 milk allergy 10.5 CD79A IL5
33 chronic tic disorder 10.5 IL13 IL5
34 bullous skin disease 10.5 CD79A IL5
35 atopic keratoconjunctivitis 10.5 IFNG IL5
36 neuroschistosomiasis 10.5 CD79A IFNG
37 sporotrichosis 10.4 CD79A IFNG
38 chronic graft versus host disease 10.4 CD79A IFNG
39 multicentric castleman disease 10.4 IFNG IL5
40 toxic oil syndrome 10.4 IFNG IL5
41 blepharoconjunctivitis 10.4 CCL11 SHE
42 lipoid nephrosis 10.4 CD79A IL13
43 microscopic colitis 10.4 CD79A IFNG
44 esophageal disease 10.4 IL13 IL5
45 blepharitis 10.4 CCL11 SHE
46 vulvovaginal candidiasis 10.4 CD79A IFNG
47 orofacial granulomatosis 10.4 CD79A IFNG
48 african tick-bite fever 10.3 IFNG IL13
49 coccidiosis 10.3 CD79A IFNG
50 penicillin allergy 10.3 IFNG IL13

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CCL11 CD79A IFNG IL13 IL5 TGFB1
2 immune system MP:0005387 9.63 CCL11 CD79A IFNG IL13 IL5 TGFB1
3 neoplasm MP:0002006 9.26 CD79A IFNG IL5 TGFB1
4 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3,Not Applicable 54965-21-8 2082
3 Anti-Infective Agents Phase 3,Not Applicable
4 Antiparasitic Agents Phase 3,Not Applicable
5 Anthelmintics Phase 3,Not Applicable
6 Antimitotic Agents Phase 3,Not Applicable
7 Antiprotozoal Agents Phase 3,Not Applicable
8
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
9
Formaldehyde Approved, Vet_approved 50-00-0 712
10
Diethylcarbamazine Approved, Investigational, Vet_approved 90-89-1 3052
11 Disinfectants
12 Ether

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 Management of Soil-transmitted Helminthiasis and Strongyloidiasis Unknown status NCT01308268 Not Applicable Ivermectin + Albendazole
4 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
5 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
6 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
7 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
8 Host Response to Infection and Treatment in Lymphatic Filarial Disease in India Recruiting NCT00342576
9 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

41
Skin, Testes, Lung, T Cells, Kidney, Colon, Liver

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 629)
# Title Authors Year
1
Severe Strongyloidiasis in Solid Organ Transplant Recipients: Should We Preventively Treat the Recipient, the Donor, or Both? ( 29363441 )
2018
2
Molecular diagnosis of strongyloidiasis in a population of an endemic area through nested-PCR. ( 29564068 )
2018
3
Molecular and Immnune Diagnosis: Further Testing for Human Strongyloidiasis. ( 29934882 )
2018
4
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
5
Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment. ( 29360939 )
2018
6
Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis. ( 29436335 )
2018
7
Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated 'hives'. ( 29348277 )
2018
8
Worming Your Way Through the Gastrointestinal Tract: A Case of Strongyloidiasis. ( 29505750 )
2018
9
Pulmonary strongyloidiasis causing septic shock in a patient with Crohn's disease. ( 29977759 )
2018
10
Periumbilical purpura: dermatoscopic findings in disseminated strongyloidiasis. ( 29740812 )
2018
11
Metaperiodate deglycosylation of Strongyloides venezuelensis larvae: Immunochemical characterization and antigen production for human strongyloidiasis diagnosis. ( 29454735 )
2018
12
Fatal pancytopenia due to albendazole treatment for strongyloidiasis. ( 29942764 )
2018
13
Detection of immune complexes and evaluation of alcoholic individuals' serological profile in the diagnosis of strongyloidiasis. ( 29933043 )
2018
14
Management of severe strongyloidiasis attended at reference centers in Spain. ( 29474356 )
2018
15
Human Strongyloidiasis in Hawaii: A Retrospective Review of Enzyme-Linked Immunosorbent Assay Serodiagnostic Testing. ( 29943712 )
2018
16
Is Ivermectin Ineffective for Strongyloidiasis? ( 29788131 )
2018
17
Image Gallery: Periumbilical purpura: aA dermatological clue for disseminated strongyloidiasis. ( 29441550 )
2018
18
Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. ( 29381575 )
2018
19
Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries. ( 28749768 )
2017
20
Twenty-five Years of Chronic Strongyloidiasis in an Immigrant. ( 28469498 )
2017
21
Intestinal strongyloidiasis: radiological findings that support the diagnosis. ( 28428660 )
2017
22
Purpuric lesion in an immunocompromised patient: a presentation of disseminated strongyloidiasis. ( 28261873 )
2017
23
An eleven-year retrospective hospital-based study of epidemiological data regarding human strongyloidiasis in northeast Thailand. ( 28923008 )
2017
24
Mass drug administration for the prevention human strongyloidiasis should consider concomitant treatment of dogs. ( 28837662 )
2017
25
Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis. ( 29239289 )
2017
26
Avidity as a criterion for diagnosis of human strongyloidiasis increases specificity of IgG ELISA. ( 28969935 )
2017
27
Strongyloides Stercoralis (Strongyloidiasis) ( 28613795 )
2017
28
Screening of immunocompromised patients at risk of strongyloidiasis in western Turkey using ELISA and real-time PCR. ( 28618740 )
2017
29
Occurrence of strongyloidiasis in privately owned and sheltered dogs: clinical presentation and treatment outcome. ( 28728589 )
2017
30
A Case of Strongyloidiasis: An Immigrant Healthcare Worker Presenting with Fatigue and Weight Loss. ( 28744381 )
2017
31
A case of adenocarcinoma developed in the small intestine with chronic strongyloidiasis. ( 28988405 )
2017
32
Strongyloidiasis ( 28613526 )
2017
33
Pulmonary strongyloidiasis: assessment between manifestation and radiological findings in 16 severe strongyloidiasis cases. ( 28464844 )
2017
34
Strongyloidiasis Current Status with Emphasis in Diagnosis and Drug Research. ( 28210503 )
2017
35
Seroepidemiological trend of strongyloidiasis in the Bolivian Chaco (1987-2013) in the absence of disease-specific control measures. ( 28929562 )
2017
36
The severely under-recognized public health risk of strongyloidiasis in North American cities-A One Health approach. ( 28670749 )
2017
37
Different but overlapping populations of Strongyloides stercoralis in dogs and humans-Dogs as a possible source for zoonotic strongyloidiasis. ( 28793306 )
2017
38
Acute strongyloidiasis in a child recently returned from vacation in Cuba. ( 29158455 )
2017
39
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells. ( 28676845 )
2017
40
Surveillance of strongyloidiasis in Spanish in-patients (1998-2014). ( 29284005 )
2017
41
Disseminated strongyloidiasis and concomitant Aspergillus infection with central nervous system involvement. ( 28139968 )
2017
42
Strongyloidiasis-Related IRIS. ( 27733639 )
2017
43
Parasitological versus molecular diagnosis of strongyloidiasis in serial stool samples: how many? ( 28112060 )
2017
44
Advocating for both Environmental and Clinical Approaches to Control Human Strongyloidiasis. ( 27706031 )
2016
45
Short epitope-based synthetic peptides for serodiagnosis of human strongyloidiasis. ( 26956434 )
2016
46
Epidemiological Characteristics of Strongyloidiasis in Inhabitants of Indigenous Communities in Borneo Island, Malaysia. ( 27853126 )
2016
47
A case of disseminated strongyloidiasis in adelaide diagnosed on peritoneal biopsy. ( 27773170 )
2016
48
Potential immunological markers for diagnosis of human strongyloidiasis using heterologous antigens. ( 27894367 )
2016
49
Acute strongyloidiasis in a traveller returning from South East Asia. ( 27192701 )
2016
50
Strong-LAMP: A LAMP Assay for Strongyloides spp. Detection in Stool and Urine Samples. Towards the Diagnosis of Human Strongyloidiasis Starting from a Rodent Model. ( 27415764 )
2016

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.2 CCL11 IFNG IL13 IL5 TGFB1
2
Show member pathways
13.07 CCL11 IFNG IL13 IL5 TGFB1
3
Show member pathways
12.6 CCL11 IFNG IL13 IL5 TGFB1
4 12.57 IFNG IL13 IL5 TGFB1
5
Show member pathways
12.36 IFNG IL13 IL5
6
Show member pathways
12.32 CD79A IL13 IL5
7
Show member pathways
12.2 IFNG IL13 IL5 TGFB1
8
Show member pathways
12.17 IFNG IL5 TGFB1
9
Show member pathways
12.07 CCL11 IFNG IL13 IL5
10 11.78 CD79A IFNG IL5
11 11.76 CCL11 IL13 TGFB1
12
Show member pathways
11.67 CCL11 IFNG IL13 IL5 TGFB1
13 11.6 IFNG IL13 IL5
14 11.57 IFNG IL13 IL5
15 11.38 IFNG TGFB1
16 11.3 IFNG TGFB1
17 11.28 IFNG TGFB1
18 11.26 CCL11 IL13 IL5 TGFB1
19 11.09 IFNG IL5
20 11.09 IFNG IL13 IL5
21 10.99 IFNG IL13 TGFB1
22 10.92 CCL11 IFNG IL13 IL5
23 10.91 IFNG IL13 IL5
24 10.4 IFNG IL13 IL5 TGFB1

GO Terms for Strongyloidiasis

Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CCL11 IFNG IL13 IL5 TGFB1

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 CCL11 IFNG IL13 IL5
2 extrinsic apoptotic signaling pathway GO:0097191 9.51 IFNG TGFB1
3 positive regulation of B cell proliferation GO:0030890 9.49 IL13 IL5
4 positive regulation of protein secretion GO:0050714 9.48 IL13 TGFB1
5 response to radiation GO:0009314 9.46 CCL11 TGFB1
6 inflammatory response GO:0006954 9.46 CCL11 IL13 IL5 TGFB1
7 protein import into nucleus, translocation GO:0000060 9.43 IFNG TGFB1
8 positive regulation of protein complex assembly GO:0031334 9.4 IFNG TGFB1
9 regulation of regulatory T cell differentiation GO:0045589 9.37 IFNG TGFB1
10 negative regulation of interleukin-17 production GO:0032700 9.26 IFNG TGFB1
11 cytokine-mediated signaling pathway GO:0019221 9.26 CCL11 IL13 IL5 TGFB1
12 regulation of signaling receptor activity GO:0010469 9.02 CCL11 IFNG IL13 IL5 TGFB1

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CCL11 IFNG IL13 IL5 TGFB1

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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