MCID: STR008
MIFTS: 53

Strongyloidiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 75 53 59 55 3 44 15 17 72 33
Disseminated Strongyloidiasis 12 72 33
Anguilluliasis 59 72
Infection by Strongyloides 12
Threadworm Infection 53
Anguillulosis 59
Enterobiasis 72

Characteristics:

Orphanet epidemiological data:

59
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD9CM 35 127.2
MeSH 44 D013322
NCIt 50 C128398
SNOMED-CT 68 1214006
ICD10 33 B78 B78.7 B78.9
MESH via Orphanet 45 D013322
ICD10 via Orphanet 34 B78.0 B78.1 B78.7 more
UMLS via Orphanet 73 C0038463 C0085810
Orphanet 59 ORPHA76
UMLS 72 C0038463 C0085810 C0086227 more

Summaries for Strongyloidiasis

CDC : 3 Strongyloidiasis is a disease caused by a nematode, or a roundworm, in the genus Strongyloides. Though there are over 40 species within this genus that can infect birds, reptiles, amphibians, livestock and other primates, Strongyloides stercoralis is the primary species that accounts for human disease. It sometimes infects primates, dogs and cats, and some dog and primate infecting strains have been shown to be capable of causing human infection. We do not know if cat-infecting strains can infect humans or not. The larvae are small; the longest reach about 600 µm in length-making them very difficult to see with the naked eye.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to hypereosinophilic syndrome and ascaris lumbricoides infection, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Albendazole and Diethylcarbamazine have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

NIH Rare Diseases : 53 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin. Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

Wikipedia : 75 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 31.3 IL5 IL13 CCL11
2 ascaris lumbricoides infection 30.9 IL5 IL13
3 schistosomiasis 30.7 IL5 IL13 IFNG
4 giardiasis 30.6 TGFB1 CD79A
5 parasitic helminthiasis infectious disease 30.6 IL5 IL13
6 enterobiasis 30.6 IL5 IL13
7 cryptosporidiosis 30.4 CD79A CCL11
8 echinococcosis 30.3 IL5 IFNG
9 paragonimiasis 30.3 IL5 IL13
10 common variable immunodeficiency 30.3 IL5 IFNG CD79A
11 intestinal schistosomiasis 30.2 IL5 IL13
12 filariasis 30.0 IL5 IFNG
13 norwegian scabies 30.0 TGFB1 IL5
14 lung disease 30.0 TGFB1 IL5 IL13
15 lipoid nephrosis 30.0 IL13 CD79A
16 pulmonary disease, chronic obstructive 29.9 TGFB1 IL13 CCL11
17 folliculitis 29.9 IL5 IFNG CCL11
18 inflammatory bowel disease 29.8 TGFB1 IL13 IFNG
19 pneumonia 29.8 IL5 IL13 CCL11
20 onchocerciasis 29.8 IL5 IL13 CCL11
21 dermatitis 29.8 IL5 IL13 IFNG CCL11
22 ige responsiveness, atopic 29.7 IL5 IL13 IFNG
23 asthma 29.7 IL5 IL13 IFNG CCL11
24 idiopathic interstitial pneumonia 29.4 TGFB1 IL13 IFNG
25 human immunodeficiency virus type 1 29.4 IFNG CD4 CCL11
26 conjunctivitis 29.3 IL5 IL13 IFNG CCL11
27 bronchiolitis 29.3 IL5 IL13 IFNG CCL11
28 allergic hypersensitivity disease 29.3 IL5 IL13 IFNG CCL11
29 diarrhea 10.6
30 allergic contact dermatitis 10.5 IL5 IFNG
31 cow milk allergy 10.5 IL5 CD79A
32 milk allergy 10.5 IL5 CD79A
33 pemphigoid gestationis 10.5 IL5 CCL11
34 chronic meningitis 10.5 IL5 CCL11
35 cephalosporin allergy 10.5 IL5 IFNG
36 eosinophilic fasciitis 10.5 IL5 IFNG
37 eosinophilic gastroenteritis 10.5 IL5 CCL11
38 scleritis 10.5 IL5 IFNG
39 sporotrichosis 10.4 IFNG CD79A
40 atopic keratoconjunctivitis 10.4 IL5 IFNG
41 cytokine deficiency 10.4 IL5 IL13
42 chronic eosinophilic pneumonia 10.4 IL5 CCL11
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL5 IL13
44 respiratory syncytial virus infectious disease 10.4 IL5 IL13
45 meningitis 10.4
46 kimura disease 10.4 IL5 CCL11
47 inflammatory bowel disease 4 10.4 IL5 IL13
48 ileus 10.4
49 apple allergy 10.4 IL5 IL13
50 multicentric castleman disease 10.4 IL5 IFNG

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 CCL11 CD4 CD53 CD79A IFNG IL13
2 digestive/alimentary MP:0005381 9.65 CD4 IFNG IL13 IL5 TGFB1
3 immune system MP:0005387 9.56 CCL11 CD4 CD53 CD79A IFNG IL13
4 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
3
Azithromycin Approved Phase 3 83905-01-5 447043 55185
4 Tubulin Modulators Phase 3
5 Antimitotic Agents Phase 3
6 Antiprotozoal Agents Phase 3
7 Lipoxygenase Inhibitors Phase 3
8 Anti-Bacterial Agents Phase 3
9
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
10 Antiparasitic Agents Phase 2
11 Anti-Infective Agents Phase 2
12 Anthelmintics Phase 2
13 Milbemycin Phase 2
14
Formaldehyde Approved, Vet_approved 50-00-0 712
15
Mebendazole Approved, Vet_approved 31431-39-7 4030
16 Disinfectants
17 Ether

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomized, Open-label, Multi Centre Phase III Clinical Trial on Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Efficacy and Safety of Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
4 A Comparative Study of Two Regimens of Ivermectin for the Treatment of Strongyloides Stercoralis Infection Recruiting NCT03605758 Phase 3 Ivermectin
5 Efficacy, Safety and Pharmacokinetics of Ascending Dosages of Moxidectin Alone and in Comparison to Ivermectin Against Strongyloidiasis Stercoralis in Adults: a Randomized Controlled Trial Not yet recruiting NCT04056325 Phase 2 Moxidectin;Ivermectin;Placebo oral tablet
6 Community-based Approach for the Management of Soil-transmitted Helminthiasis in General and Strongyloidiasis in Particular in a Highly Endemic Area Unknown status NCT01308268 Ivermectin + Albendazole
7 Study of Patients With Known or Suspected Infection With Strongyloides Stercoralis Completed NCT00001245
8 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
9 Host Response to Infection and Treatment in Lymphatic Filarial Disease Strongyloidiasis in India Completed NCT00342576
10 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
11 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
12 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Albendazole
Ivermectin
Mebendazole
Mebendazole
Pyrantel
Pyrantel Pamoate
Thiabendazole

Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

41
Skin, Testes, T Cells, Lung, Eye, Kidney, Small Intestine

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 1816)
# Title Authors PMID Year
1
Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. 9 38
19513105 2009
2
Eosinophil-selective mediators in human strongyloidiasis. 9 38
16879311 2006
3
The mutual influence of nematode infection and allergy. 9 38
16210900 2006
4
Strongyloides ratti antigenic components recognized by IgE antibodies in immunoblotting as an additional tool for improving the immunodiagnosis in human strongyloidiasis. 9 38
15057354 2004
5
Heterologous antigen extract in ELISA for the detection of human IgE anti-Strongyloides stercoralis. 9 38
14743666 2003
6
Immunoglobulin-E and anti-IgE treatment in lung disease. 9 38
11980283 2001
7
A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis. 9 38
11802274 2001
8
Influence of human T-cell lymphocytotropic virus type 1 infection on serologic and skin tests for strongyloidiasis. 9 38
11716123 2001
9
HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. 9 38
11589779 2001
10
L3 antigen-specific antibody isotype responses in human strongyloidiasis: correlations with larval output. 9 38
10587378 1999
11
Differentially enhanced cytokine gene expression in CD4+ and CD8+ T cells in mesenteric lymph nodes in rats infected with Nippostrongylus brasiliensis. 9 38
10610496 1999
12
Interferon-gamma and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis. 9 38
9815251 1998
13
Humoral responses in human strongyloidiasis: correlations with infection chronicity. 9 38
9463683 1997
14
Total serum IgE and parasite-specific IgG and IgA antibodies in human strongyloidiasis. 9 38
8115797 1993
15
Strongyloides stercoralis hyperinfection in a carrier of HTLV-I virus with evidence of selective immunosuppression. 9 38
1543206 1992
16
Highly specific and sensitive anti-Strongyloides venezuelensis IgY antibodies applied to the human strongyloidiasis immunodiagnosis. 38
31128257 2019
17
Parasitic infections in Malaysian aborigines with pulmonary tuberculosis: a comparative cross-sectional study. 38
31363922 2019
18
First molecular identification of Strongyloides fuelleborni in long-tailed macaques in Thailand and Lao People's Democratic Republic reveals considerable genetic diversity. 38
30027858 2019
19
Ivermectin: From theory to clinical application. 38
31071469 2019
20
Case Report: Two Cases of Strongyloidiasis Presenting with Thrombotic Events. 38
31218995 2019
21
Lateral Flow Dipstick Test for Serodiagnosis of Strongyloidiasis. 38
31218996 2019
22
Strongyloides stercoralis Infection at Different Altitudes of the Cusco Region in Peru. 38
31264557 2019
23
Utility of PCR in Patients with Strongyloides stercoralis and HTLV-1 Coinfection in French Guiana. 38
31436152 2019
24
Detection of classic and cryptic Strongyloides genotypesby deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities. 38
31430282 2019
25
Septic Meningitis and Liver Abscess due to Hypermucoviscous Klebsiella pneumoniae Complicated with Chronic Strongyloidiasis in a Human T-lymphotropic Virus 1 Carrier. 38
31434825 2019
26
Clinical and Diagnostic Features of 413 Patients Treated for Imported Strongyloidiasis at the Hospital for Tropical Diseases, London. 38
31219002 2019
27
Methotrexate exposure and risk of strongyloidiasis. 38
31302948 2019
28
Strongyloidiasis hyperinfection after renal transplant presenting as diffuse alveolar hemorrhage with respiratory failure. 38
31384205 2019
29
Disseminated strongyloidiasis complicated by alveolar hemorrhage, meningitis, and septic shock treated with albendazole and subcutaneous ivermectin. 38
31279610 2019
30
Corticosteroid-induced immunodeficiency in a patient with gliomatosis cerebri: Are corticosteroids indicated in all brain tumors? 38
30964431 2019
31
Strongyloides stercoralis infection in human immunodeficiency virus-infected patients and related risk factors: A systematic review and meta-analysis. 38
31359566 2019
32
Prevalence and risk factors of Strongyloides stercoralis infection among Orang Asli schoolchildren: new insights into the epidemiology, transmission and diagnosis of strongyloidiasis in Malaysia. 38
31303180 2019
33
Seroprevalence of Strongyloides stercoralis and Evaluation of Universal Screening in Kidney Transplant Candidates: A Single-Center Experience in Houston (2012-2017). 38
31363770 2019
34
The Anthelmintic effect on Strongyloides venezuelensis induced by BnSP-6, a Lys49-phospholipase A2 homologue from Bothrops pauloensis venom. 38
31340738 2019
35
HTLV-1-associated adult T-cell leukemia/lymphoma with disseminated strongyloidiasis. 38
31196878 2019
36
Microfilaria and Strongyloides larva diagnosed in cerebrospinal fluid and ascitic fluid, respectively: Approach to their morphology on cytology. 38
31211515 2019
37
Disseminated Strongyloidiasis. 38
31188402 2019
38
Strongyloidiasis in Ethiopia: systematic review on risk factors, diagnosis, prevalence and clinical outcomes. 38
31200770 2019
39
Strongyloides stercoralis in Patients on Corticosteroids Therapy Using Enzyme-Linked Immunosorbent Assay and Gelatin Particles Indirect Agglutination Tests: A Diagnostic Approach. 38
31069645 2019
40
Morbidity Associated with Chronic Strongyloides stercoralis Infection: A Systematic Review and Meta-Analysis. 38
30963990 2019
41
Strongyloides stercoralis hyperinfection syndrome: a deeper understanding of a neglected disease. 38
31263320 2019
42
Serodiagnosis and early detection of Strongyloides stercoralis infection. 38
30482708 2019
43
Parasitic Infections of the Stem Cell Transplant Recipient and the Hematologic Malignancy Patient, Including Toxoplasmosis and Strongyloidiasis. 38
31005139 2019
44
Production of recombinant 14-3-3 protein and determination of its immunogenicity for application in serodiagnosis of strongyloidiasis. 38
30856271 2019
45
Imported strongyloidiasis: Data from 1245 cases registered in the +REDIVI Spanish Collaborative Network (2009-2017). 38
31095570 2019
46
Disseminated strongyloidiasis in an immunocompetent male: A Case Report. 38
31105313 2019
47
[Screening the asymptomatic traveler returning from the tropics]. 38
31050236 2019
48
A case report suggestive of strongyloidiasis infection occurring in temperate Australia. 38
31084034 2019
49
Comparison of ELISA and PCR of the 18S rRNA gene for detection of human strongyloidiasis using serum sample. 38
30773081 2019
50
Strongyloides stercoralis infection in a patient with rheumatoid arthritis and type 2 diabetes mellitus: a case-based review. 38
31123976 2019

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 TGFB1 IL5 IL13 IFNG CD79A CD53
2
Show member pathways
13.45 TGFB1 IL5 IL13 IFNG CD4 CCL11
3
Show member pathways
13.31 TGFB1 IL5 IL13 IFNG CD4 CCL11
4
Show member pathways
13.18 TGFB1 IL5 IL13 CD4 CCL11
5
Show member pathways
13.12 TGFB1 IL5 IL13 IFNG CD4 CCL11
6
Show member pathways
13.07 TGFB1 IL5 IL13 CD4 CCL11
7
Show member pathways
12.65 TGFB1 IL5 IL13 IFNG CD4 CCL11
8 12.64 TGFB1 IL5 IL13 IFNG
9
Show member pathways
12.41 TGFB1 IL5 IL13 IFNG CD4
10
Show member pathways
12.39 TGFB1 IL5 IFNG CD4
11
Show member pathways
12.19 IL5 IL13 IFNG
12
Show member pathways
12.16 IL5 IL13 IFNG CCL11
13
Show member pathways
12.09 TGFB1 IL5 IL13 IFNG
14
Show member pathways
11.9 TGFB1 IFNG CD4
15 11.82 TGFB1 IL13 CCL11
16 11.82 IL5 IFNG CD79A CD4
17
Show member pathways
11.75 TGFB1 IL5 IL13 IFNG CD4 CCL11
18 11.67 IL5 IL13 IFNG
19 11.61 IL5 IL13 IFNG CD4
20 11.6 TGFB1 IFNG CD4
21 11.52 TGFB1 IL13 IFNG CCL11
22 11.42 TGFB1 IL5 IL13 CCL11
23 11.35 TGFB1 IFNG
24 11.34 TGFB1 IFNG
25 11.21 CD79A CD4
26 11.19 IL5 IL13 IFNG
27 11.16 IL5 IFNG
28 11.09 IL5 IL13 IFNG
29 11.04 IL5 IL13 CCL11
30 11.02 IL5 IL13 IFNG CD4 CCL11
31 10.9 TGFB1 IL13 IFNG CD4
32 10.83 TGFB1 IL5 IL13 CCL11
33 10.48 TGFB1 IL5 IL13 IFNG CD4

GO Terms for Strongyloidiasis

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.74 IFNG CD79A CD4
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.69 TGFB1 CD4 CCL11
3 positive regulation of protein phosphorylation GO:0001934 9.63 TGFB1 IFNG CD4
4 inflammatory response GO:0006954 9.62 TGFB1 IL5 IL13 CCL11
5 T cell activation GO:0042110 9.58 TGFB1 CD4
6 extrinsic apoptotic signaling pathway GO:0097191 9.56 TGFB1 IFNG
7 positive regulation of protein secretion GO:0050714 9.55 TGFB1 IL13
8 positive regulation of B cell proliferation GO:0030890 9.54 IL5 IL13
9 T cell differentiation GO:0030217 9.52 TGFB1 CD4
10 response to radiation GO:0009314 9.49 TGFB1 CCL11
11 positive regulation of protein complex assembly GO:0031334 9.48 TGFB1 IFNG
12 response to vitamin D GO:0033280 9.43 TGFB1 CD4
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 TGFB1 IL5 CD4
14 regulation of regulatory T cell differentiation GO:0045589 9.4 TGFB1 IFNG
15 negative regulation of interleukin-17 production GO:0032700 9.37 TGFB1 IFNG
16 immune response GO:0006955 9.35 IL5 IL13 IFNG CD4 CCL11
17 cell surface receptor signaling pathway GO:0007166 9.33 IFNG CD79A CD4
18 cytokine-mediated signaling pathway GO:0019221 9.02 TGFB1 IL5 IL13 CD4 CCL11

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.61 TGFB1 SHE IL5 IL13 IFNG CD79A
2 cytokine activity GO:0005125 9.02 TGFB1 IL5 IL13 IFNG CCL11

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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