MCID: STR008
MIFTS: 55

Strongyloidiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 76 53 59 55 3 44 15 73
Disseminated Strongyloidiasis 12 73
Anguilluliasis 59 73
Infection by Strongyloides 12
Threadworm Infection 53
Anguillulosis 59
Enterobiasis 73

Characteristics:

Orphanet epidemiological data:

59
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD10 33 B78 B78.9 B78.7
ICD9CM 35 127.2
MeSH 44 D013322
NCIt 50 C128398
SNOMED-CT 68 1214006
Orphanet 59 ORPHA76
MESH via Orphanet 45 D013322
ICD10 via Orphanet 34 B78.0 B78.9 B78.1 more
UMLS via Orphanet 74 C0038463 C0085810

Summaries for Strongyloidiasis

NIH Rare Diseases : 53 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin. Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to schistosomiasis and enterobiasis, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

CDC : 3 Strongyloidiasis was first described in French troops stationed in modern day Vietnam during the late 19th century who were suffering from severe, persistent diarrhea. It is a parasitic disease caused by nematodes, or roundworms, in the genus Strongyloides that enter the body through exposed skin, such as bare feet. Strongyloides is most common in tropical or subtropical climates.

Wikipedia : 76 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.4 IL5 IL13 IFNG
2 enterobiasis 30.0 IL5 IL13
3 common variable immunodeficiency 30.0 IL5 IFNG CD79A
4 giardiasis 30.0 TGFB1 CD79A
5 pneumonia 29.9 IL5 IL13 CCL11
6 filariasis 29.9 IL5 IFNG
7 paragonimiasis 29.9 IL5 IL13
8 intestinal schistosomiasis 29.8 IL5 IL13
9 cryptosporidiosis 29.8 CD79A CCL11
10 pulmonary disease, chronic obstructive 29.8 TGFB1 IL13 CCL11
11 asthma 29.7 TGFB1 IL5 IL13 IFNG CCL11
12 folliculitis 29.7 IL5 IFNG CCL11
13 dermatitis 29.4 IL5 IL13 IFNG CCL11
14 inflammatory bowel disease 29.1 CCL11 IFNG IL13 IL5 TGFB1
15 meningitis 10.2
16 cow milk allergy 10.2 IL5 CD79A
17 milk allergy 10.2 IL5 CD79A
18 nephrotic syndrome 10.2
19 pemphigoid gestationis 10.2 IL5 CCL11
20 chronic meningitis 10.2 IL5 CCL11
21 allergic contact dermatitis 10.2 IL5 IFNG
22 cytokine deficiency 10.2 IL5 IL13
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 IL5 IL13
24 respiratory syncytial virus infectious disease 10.2 IL5 IL13
25 eosinophilic gastroenteritis 10.2 IL5 CCL11
26 chronic eosinophilic pneumonia 10.2 IL5 CCL11
27 apple allergy 10.2 IL5 IL13
28 cephalosporin allergy 10.2 IL5 IFNG
29 inflammatory bowel disease 4 10.2 IL5 IL13
30 eosinophilic fasciitis 10.2 IL5 IFNG
31 kimura disease 10.2 IL5 CCL11
32 latex allergy 10.2 IL5 IL13
33 scleritis 10.2 IL5 IFNG
34 sporotrichosis 10.2 IFNG CD79A
35 atopic keratoconjunctivitis 10.2 IL5 IFNG
36 chronic tic disorder 10.2 IL5 IL13
37 cardiac sarcoidosis 10.2 IL5 IFNG
38 chronic graft versus host disease 10.2 IFNG CD79A
39 purpura 10.1
40 radiculopathy 10.1 IL5 CCL11
41 african tick-bite fever 10.1 IL13 IFNG
42 toxic oil syndrome 10.1 IL5 IFNG
43 penicillin allergy 10.1 IL13 IFNG
44 pollen allergy 10.1 IL5 IL13
45 systemic lupus erythematosus 10.1
46 lymphoma 10.1
47 lupus erythematosus 10.1
48 orofacial granulomatosis 10.1 IFNG CD79A
49 norwegian scabies 10.1 TGFB1 IL5
50 lipoid nephrosis 10.1 IL13 CD79A

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CD53 CD79A IFNG IL13 IL5
2 immune system MP:0005387 9.5 CCL11 CD53 CD79A IFNG IL13 IL5
3 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3,Not Applicable 54965-21-8 2082
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
4
Azithromycin Approved Phase 3 83905-01-5 55185 447043
5 Anti-Infective Agents Phase 3,Not Applicable
6 Antiparasitic Agents Phase 3,Not Applicable
7 Anthelmintics Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 3,Not Applicable
9 Antimitotic Agents Phase 3,Not Applicable
10 Lipoxygenase Inhibitors Phase 3
11 Anti-Bacterial Agents Phase 3
12
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
13
Formaldehyde Approved, Vet_approved 50-00-0 712
14 Disinfectants
15 Ether

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 Treatment of Strongyloides Infection Recruiting NCT03605758 Phase 3 Ivermectin
4 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Not yet recruiting NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
5 Management of Soil-transmitted Helminthiasis and Strongyloidiasis Unknown status NCT01308268 Not Applicable Ivermectin + Albendazole
6 Host Response to Infection and Treatment in Lymphatic Filarial Disease in India Completed NCT00342576
7 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
8 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
9 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
10 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
11 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

41
Skin, Testes, Lung, T Cells, Colon, Tonsil, B Cells

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 772)
# Title Authors Year
1
Severe Strongyloidiasis in Solid Organ Transplant Recipients: Should We Preventively Treat the Recipient, the Donor, or Both? ( 29363441 )
2018
2
Molecular diagnosis of strongyloidiasis in a population of an endemic area through nested-PCR. ( 29564068 )
2018
3
Molecular and Immnune Diagnosis: Further Testing for Human Strongyloidiasis. ( 29934882 )
2018
4
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
5
Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment. ( 29360939 )
2018
6
Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis. ( 29436335 )
2018
7
Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated 'hives'. ( 29348277 )
2018
8
Worming Your Way Through the Gastrointestinal Tract: A Case of Strongyloidiasis. ( 29505750 )
2018
9
Pulmonary strongyloidiasis causing septic shock in a patient with Crohn's disease. ( 29977759 )
2018
10
Periumbilical purpura: dermatoscopic findings in disseminated strongyloidiasis. ( 29740812 )
2018
11
Metaperiodate deglycosylation of Strongyloides venezuelensis larvae: Immunochemical characterization and antigen production for human strongyloidiasis diagnosis. ( 29454735 )
2018
12
Fatal pancytopenia due to albendazole treatment for strongyloidiasis. ( 29942764 )
2018
13
Detection of immune complexes and evaluation of alcoholic individuals' serological profile in the diagnosis of strongyloidiasis. ( 29933043 )
2018
14
Management of severe strongyloidiasis attended at reference centers in Spain. ( 29474356 )
2018
15
Human Strongyloidiasis in Hawaii: A Retrospective Review of Enzyme-Linked Immunosorbent Assay Serodiagnostic Testing. ( 29943712 )
2018
16
Is Ivermectin Ineffective for Strongyloidiasis? ( 29788131 )
2018
17
Image Gallery: Periumbilical purpura: aA dermatological clue for disseminated strongyloidiasis. ( 29441550 )
2018
18
Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. ( 29381575 )
2018
19
Disseminated Strongyloidiasis in Association with Nephrotic Syndrome. ( 30197904 )
2018
20
Strongyloidiasis and Culture-Negative Suppurative Meningitis, Japan, 1993-2015. ( 30457540 )
2018
21
Parasitological versus molecular diagnosis of strongyloidiasis in serial stool samples: how many? ( 28112060 )
2018
22
Diagnostic performance of urinary IgG antibody detection: A novel approach for population screening of strongyloidiasis. ( 29985913 )
2018
23
OCCASIONAL DIGESTIVE HEMORRHAGE IN CHILDREN DUE TO STRONGYLOIDIASIS: IMPORTANCE OF PARASITOLOGIC TESTING. ( 30066826 )
2018
24
Investigations for the Possible Use of a Monoclonal Antibody Produced against Strongyloides ratti Antigen as an Immunodiagnostic Reagent for Active Strongyloidiasis. ( 30069204 )
2018
25
Strongyloidiasis in humans: diagnostic efficacy of four conventional methods and real-time polymerase chain reaction. ( 30133633 )
2018
26
Strongyloidiasis Presenting as Yellowish Nodules in Colonoscopy of an Immunocompetent Patient. ( 30157619 )
2018
27
Enterobius vermicularis infection mimicking strongyloidiasis: A case report. ( 30190233 )
2018
28
Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy. ( 30226142 )
2018
29
Pulmonary strongyloidiasis presenting micronodules on chest computed tomography. ( 30233896 )
2018
30
A case of chronic strongyloidiasis diagnosed by histopathological study. ( 30261269 )
2018
31
The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review. ( 30274446 )
2018
32
Argument for Inclusion of Strongyloidiasis in the Australian National Notifiable Disease List. ( 30274457 )
2018
33
Paediatric Strongyloidiasis in Central Australia. ( 30274460 )
2018
34
Donor-derived strongyloidiasis after organ transplantation in Norway. ( 30295406 )
2018
35
Severe strongyloidiasis and systemic vasculitis: comorbidity, association or both? Case-based review. ( 30353268 )
2018
36
Hypermetabolic Diffuse Proximal Small Bowel Wall Thickening on Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography? Consider Strongyloidiasis among the Differentials. ( 30386068 )
2018
37
Accuracy of Urine and Serum Assays for the Diagnosis of Strongyloidiasis by Three Enzyme-Linked Immunosorbent Assay Protocols. ( 30398144 )
2018
38
Fatal strongyloidiasis after corticosteroid therapy for presumed chronic obstructive pulmonary disease. ( 30425838 )
2018
39
Case Report: Central Nervous System Strongyloidiasis: Two Cases Diagnosed Antemortem. ( 30457095 )
2018
40
Gastroduodenal involvement in disseminated strongyloidiasis. ( 30483566 )
2018
41
Evidence-Based Guidelines for Screening and Management of Strongyloidiasis in Non-Endemic Countries. ( 28749768 )
2017
42
Twenty-five Years of Chronic Strongyloidiasis in an Immigrant. ( 28469498 )
2017
43
Intestinal strongyloidiasis: radiological findings that support the diagnosis. ( 28428660 )
2017
44
Purpuric lesion in an immunocompromised patient: a presentation of disseminated strongyloidiasis. ( 28261873 )
2017
45
An eleven-year retrospective hospital-based study of epidemiological data regarding human strongyloidiasis in northeast Thailand. ( 28923008 )
2017
46
Mass drug administration for the prevention human strongyloidiasis should consider concomitant treatment of dogs. ( 28837662 )
2017
47
Immune complex detection in saliva samples: an innovative proposal for the diagnosis of human strongyloidiasis. ( 29239289 )
2017
48
Avidity as a criterion for diagnosis of human strongyloidiasis increases specificity of IgG ELISA. ( 28969935 )
2017
49
Strongyloides Stercoralis (Strongyloidiasis) ( 28613795 )
2017
50
Screening of immunocompromised patients at risk of strongyloidiasis in western Turkey using ELISA and real-time PCR. ( 28618740 )
2017

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 CD53 CD79A IFNG IL13 IL5
2
Show member pathways
13.27 CCL11 IFNG IL13 IL5 TGFB1
3
Show member pathways
13.1 CCL11 IFNG IL13 IL5 TGFB1
4
Show member pathways
12.61 CCL11 IFNG IL13 IL5 TGFB1
5 12.59 IFNG IL13 IL5 TGFB1
6
Show member pathways
12.38 IFNG IL13 IL5 TGFB1
7
Show member pathways
12.2 IFNG IL5 TGFB1
8
Show member pathways
12.16 IFNG IL13 IL5
9
Show member pathways
12.09 CCL11 IFNG IL13 IL5
10
Show member pathways
12.03 IFNG IL13 IL5 TGFB1
11 11.8 CD79A IFNG IL5
12 11.78 CCL11 IL13 TGFB1
13
Show member pathways
11.73 CCL11 IFNG IL13 IL5 TGFB1
14 11.6 IFNG IL13 IL5
15 11.57 IFNG IL13 IL5
16 11.41 CCL11 IFNG IL13 TGFB1
17 11.32 IFNG TGFB1
18 11.3 IFNG TGFB1
19 11.26 CCL11 IL13 IL5 TGFB1
20 11.12 IFNG IL5
21 11.11 IFNG IL13 IL5
22 11.03 IFNG IL13 TGFB1
23 10.99 CCL11 IL13 IL5
24 10.96 IFNG IL13 IL5
25 10.92 CCL11 IFNG IL13 IL5
26 10.78 CCL11 IL13 IL5 TGFB1
27 10.39 IFNG IL13 IL5 TGFB1

GO Terms for Strongyloidiasis

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.69 CD53 CD79A IFNG
2 immune response GO:0006955 9.67 CCL11 IFNG IL13 IL5
3 extrinsic apoptotic signaling pathway GO:0097191 9.52 IFNG TGFB1
4 positive regulation of B cell proliferation GO:0030890 9.49 IL13 IL5
5 positive regulation of protein secretion GO:0050714 9.48 IL13 TGFB1
6 response to radiation GO:0009314 9.46 CCL11 TGFB1
7 inflammatory response GO:0006954 9.46 CCL11 IL13 IL5 TGFB1
8 positive regulation of protein complex assembly GO:0031334 9.43 IFNG TGFB1
9 protein import into nucleus, translocation GO:0000060 9.4 IFNG TGFB1
10 regulation of regulatory T cell differentiation GO:0045589 9.32 IFNG TGFB1
11 negative regulation of interleukin-17 production GO:0032700 9.26 IFNG TGFB1
12 cytokine-mediated signaling pathway GO:0019221 9.26 CCL11 IL13 IL5 TGFB1
13 regulation of signaling receptor activity GO:0010469 9.02 CCL11 IFNG IL13 IL5 TGFB1

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.61 CCL11 CD53 CD79A IFNG IL13 IL5
2 cytokine activity GO:0005125 9.02 CCL11 IFNG IL13 IL5 TGFB1

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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