MCID: STR008
MIFTS: 51

Strongyloidiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 74 52 58 54 3 43 15 17 71 32
Disseminated Strongyloidiasis 12 71 32
Anguilluliasis 58 71
Infection by Strongyloides 12
Threadworm Infection 52
Anguillulosis 58
Enterobiasis 71

Characteristics:

Orphanet epidemiological data:

58
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD9CM 34 127.2
MeSH 43 D013322
NCIt 49 C128398
SNOMED-CT 67 1214006
ICD10 32 B78 B78.7 B78.9
MESH via Orphanet 44 D013322
ICD10 via Orphanet 33 B78.0 B78.1 B78.7 more
UMLS via Orphanet 72 C0038463 C0085810
Orphanet 58 ORPHA76
UMLS 71 C0038463 C0085810 C0086227 more

Summaries for Strongyloidiasis

CDC : 3 Strongyloidiasis is a disease caused by a nematode, or a roundworm, in the genus Strongyloides. Though there are over 40 species within this genus that can infect birds, reptiles, amphibians, livestock and other primates, Strongyloides stercoralis is the primary species that accounts for human disease. It sometimes infects primates, dogs and cats, and some dog and primate infecting strains have been shown to be capable of causing human infection. We do not know if cat-infecting strains can infect humans or not. The larvae are small; the longest reach about 600 µm in length-making them very difficult to see with the naked eye.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to filariasis and respiratory failure, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Albendazole and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

NIH Rare Diseases : 52 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin . Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

Wikipedia : 74 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 471)
# Related Disease Score Top Affiliating Genes
1 filariasis 30.7 LGALS3BP IL5 IGHE IFNG
2 respiratory failure 30.5 IL5 IL13 CD4 CCL11
3 meningitis 30.5 IL5 IFNG CD40LG
4 hypereosinophilic syndrome 30.5 IL5 IL3 IL13 IGHE IFNG CCL11
5 enterobiasis 30.3 STH EPGN
6 scabies 30.3 IL5 CD4 CCL11
7 diarrhea 30.3 TGFB1 IL5 IFNG CD40LG
8 intestinal tuberculosis 30.3 IFNG CD4
9 loiasis 30.3 IL5 IL13
10 necatoriasis 30.2 IL5 EPGN
11 trichuriasis 30.1 STH IL13 EPGN
12 allergic bronchopulmonary aspergillosis 30.1 IL5 IGHE IFNG
13 urticaria 30.1 IL5 IL13 IGHE CD40LG
14 dermatitis 30.1 IL5 IL13 IGHE IFNG CCL11
15 t-cell adult acute lymphocytic leukemia 30.0 HBZ CD7 CD4
16 cryptococcosis 29.9 IL13 IFNG CD4
17 ige responsiveness, atopic 29.9 IL5 IL13 IGHE IFNG
18 idiopathic interstitial pneumonia 29.9 TGFB1 IL13 IFNG
19 angioedema 29.8 IL5 IGHE CD40LG
20 pulmonary disease, chronic obstructive 29.8 TGFB1 IL5 IL13 CD4 CCL11
21 amebiasis 29.7 CD79A CD40LG CD4
22 paragonimiasis 29.7 IL5 IL13 IGHE EPGN
23 gastroenteritis 29.7 IL5 IL3 IFNG CCL11
24 acquired immunodeficiency syndrome 29.7 IFNG CD79A CD40LG CD4
25 ascaris lumbricoides infection 29.7 STH IL5 IL13 IFNG EPGN
26 coccidiosis 29.7 IFNG CD40LG CD4
27 folliculitis 29.7 IL5 IFNG CD4 CCL11
28 toxocariasis 29.7 IL5 IGHE EPGN CD40LG
29 leishmaniasis 29.7 TGFB1 IL5 IL13 IFNG
30 chagas disease 29.7 TGFB1 IFNG CD4
31 cysticercosis 29.6 IGHE CD40LG CD4
32 giardiasis 29.6 TGFB1 CD79A CD40LG CD4
33 common variable immunodeficiency 29.6 IL5 IFNG CD79A CD40LG
34 conjunctivitis 29.6 IL5 IL13 IGHE IFNG CCL11
35 lung abscess 29.5 IFNG CD40LG CD4
36 lipoid nephrosis 29.5 IL13 CD79A CD40LG
37 schistosomiasis 29.5 TGFB1 IL5 IL13 IGHE IFNG CD40LG
38 echinococcosis 29.4 IL5 IGHE IFNG CD79A CD40LG
39 immune deficiency disease 29.4 IL13 IFNG CD79A CD40LG CD4
40 immunoglobulin alpha deficiency 29.4 CD79A CD40LG CD4
41 meningoencephalitis 29.4 CD79A CD40LG CD4
42 lung disease 29.3 TGFB1 IL5 IL13 IFNG CD40LG
43 cryptosporidiosis 29.3 CD79A CD40LG CD4 CCL11
44 temporal arteritis 29.2 IFNG CD40LG CD4
45 bronchitis 29.2 IL5 IL13 IGHE CD40LG CCL11
46 filarial elephantiasis 29.2 STH IL5 IL13 EPGN CD4
47 bacterial infectious disease 29.2 IL3 IFNG CD40LG CD4
48 drug allergy 29.2 IL5 IGHE CD40LG CD4
49 norwegian scabies 29.2 IL5 IL13 CD40LG CD4
50 onchocerciasis 29.1 STH LGALS3BP IL5 IL13 IGHE CCL11

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CD4 CD40LG CD7 CD79A EPGN
2 immune system MP:0005387 9.36 CCL11 CD4 CD40LG CD7 CD79A EPGN

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2
Azithromycin Approved Phase 3 83905-01-5 55185 447043
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
4 Antimitotic Agents Phase 3
5 Antiprotozoal Agents Phase 3
6 Anti-Bacterial Agents Phase 3
7
Ivermectin Approved, Investigational, Vet_approved Phase 2 70288-86-7 6474909
8 Antiparasitic Agents Phase 2
9 Anti-Infective Agents Phase 2
10 Anthelmintics Phase 2
11 Milbemycin Phase 2
12
Formaldehyde Approved, Vet_approved 50-00-0 712
13
Mebendazole Approved, Vet_approved 31431-39-7 4030
14 Ether
15 Disinfectants

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomized, Open-label, Multi Centre Phase III Clinical Trial on Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Efficacy and Safety of Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
4 A Comparative Study of Two Regimens of Ivermectin for the Treatment of Strongyloides Stercoralis Infection Recruiting NCT03605758 Phase 3 Ivermectin
5 Efficacy, Safety and Pharmacokinetics of Ascending Dosages of Moxidectin Alone and in Comparison to Ivermectin Against Strongyloidiasis Stercoralis in Adults: a Randomized Controlled Trial Not yet recruiting NCT04056325 Phase 2 Moxidectin;Ivermectin;Placebo oral tablet
6 Community-based Approach for the Management of Soil-transmitted Helminthiasis in General and Strongyloidiasis in Particular in a Highly Endemic Area Unknown status NCT01308268 Ivermectin + Albendazole
7 Study of Patients With Known or Suspected Infection With Strongyloides Stercoralis Completed NCT00001245
8 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
9 Host Response to Infection and Treatment in Lymphatic Filarial Disease Strongyloidiasis in India Completed NCT00342576
10 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
11 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
12 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate
Thiabendazole

Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

40
Skin, T Cells, Lung, Testes, Eye, Kidney, Bone

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 1860)
# Title Authors PMID Year
1
Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. 54 61
19513105 2009
2
Eosinophil-selective mediators in human strongyloidiasis. 54 61
16879311 2006
3
The mutual influence of nematode infection and allergy. 54 61
16210900 2006
4
Strongyloides ratti antigenic components recognized by IgE antibodies in immunoblotting as an additional tool for improving the immunodiagnosis in human strongyloidiasis. 54 61
15057354 2004
5
Heterologous antigen extract in ELISA for the detection of human IgE anti-Strongyloides stercoralis. 54 61
14743666 2003
6
A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis. 54 61
11802274 2001
7
Immunoglobulin-E and anti-IgE treatment in lung disease. 54 61
11980283 2001
8
Influence of human T-cell lymphocytotropic virus type 1 infection on serologic and skin tests for strongyloidiasis. 54 61
11716123 2001
9
HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. 54 61
11589779 2001
10
Differentially enhanced cytokine gene expression in CD4+ and CD8+ T cells in mesenteric lymph nodes in rats infected with Nippostrongylus brasiliensis. 54 61
10610496 1999
11
L3 antigen-specific antibody isotype responses in human strongyloidiasis: correlations with larval output. 54 61
10587378 1999
12
Interferon-gamma and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis. 54 61
9815251 1998
13
Humoral responses in human strongyloidiasis: correlations with infection chronicity. 54 61
9463683 1997
14
Total serum IgE and parasite-specific IgG and IgA antibodies in human strongyloidiasis. 54 61
8115797 1993
15
Strongyloides stercoralis hyperinfection in a carrier of HTLV-I virus with evidence of selective immunosuppression. 54 61
1543206 1992
16
Mapping the Prevalence of Strongyloides stercoralis Infection in Ecuador: A Serosurvey. 61
31833465 2020
17
Rapid Progress toward Elimination of Strongyloidiasis in North Queensland, Tropical Australia, 2000-2018. 61
31802738 2020
18
Progress towards the Control of Strongyloidiasis in Tropical Australia? 61
31912774 2020
19
Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants. 61
31914335 2020
20
Schistosomiasis, strongyloidiasis and Chagas disease: the leading imported neglected tropical diseases in Italy. 61
31840757 2020
21
Epidemiology of Parasitic Infections in the West Bank and Gaza Strip, Palestine. 61
31769396 2020
22
Ivermectin concentration in breastmilk of a woman with Strongyloides stercoralis and human T-lymphotropic virus-I co-infection. 61
31678122 2020
23
Parasitological and immunological aspects of oral and subcutaneous prednisolone treatment in rats experimentally infected with Strongyloides venezuelensis. 61
31958413 2020
24
Septic Meningitis and Liver Abscess due to Hypermucoviscous Klebsiella pneumoniae Complicated with Chronic Strongyloidiasis in a Human T-lymphotropic Virus 1 Carrier. 61
31434825 2020
25
Strategies for management of strongyloidiasis in migrants from Sub-Saharan Africa recently arrived in Italy: A cost-effectiveness analysis. 61
31982632 2020
26
Shotgun proteomics of Strongyloides venezuelensis infective third stage larvae: Insights into host-parasite interaction and novel targets for diagnostics. 61
31881239 2020
27
Schistosoma and Strongyloides screening in migrants initiating HIV Care in Canada: a cross sectional study. 61
31992216 2020
28
PICTORIAL REVIEW OF THORACIC PARASITIC DISEASES: A RADIOLOGICAL GUIDE. 61
31978430 2020
29
Donor-derived fatal hyperinfection strongyloidiasis in renal transplant recipient. 61
32021802 2020
30
Transplant-related strongyloidiasis in solid organ transplant recipients in Saudi Arabia and the GCC countries. 61
31982623 2020
31
Strongyloides stercoralis: a rare and severe presentation in a pregnant woman. 61
31814031 2019
32
Dogs are reservoir hosts for possible transmission of human strongyloidiasis in Thailand: molecular identification and genetic diversity of causative parasite species. 61
31843028 2019
33
Evaluation of the Dot-ELISA as a diagnostic test for human strongyloidiasis based on the detection of IgA in saliva. 61
31862463 2019
34
Improved agar plate culture conditions for diagnosis of Strongyloides stercoralis. 61
31816322 2019
35
Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care. 61
31845476 2019
36
Advances in the Molecular and Cellular Biology of Strongyloides spp. 61
31929961 2019
37
Assessment of the global paradigms of genetic variability in Strongyloides stercoralis infrapopulations determined by mitochondrial DNA sequences. 61
31586852 2019
38
HTLV-1 infection: An emerging risk. Pathogenesis, epidemiology, diagnosis and associated diseases. 61
31648512 2019
39
Alcohol consumption alters anti-Strongyloides stercoralis antibodies production. 61
31902530 2019
40
Strongyloides stercoralis infection in a patient with rheumatoid arthritis and type 2 diabetes mellitus: a case-based review. 61
31123976 2019
41
Bacillus thuringiensis Cry5B is Active against Strongyloides stercoralis in vitro. 61
31516117 2019
42
Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase 3, randomised controlled superiority trial. 61
31558376 2019
43
Strongyloides stercoralis infection in human immunodeficiency virus-infected patients and related risk factors: A systematic review and meta-analysis. 61
31359566 2019
44
Use of serology in a systematic screening programme for strongyloidiasis in an immigrant population. 61
31499208 2019
45
Strongyloidiasis in northern Vietnam: epidemiology, clinical characteristics and molecular diagnosis of the causal agent. 61
31685003 2019
46
Strongyloidiasis screening in migrants living in Spain: systematic review and meta-analysis. 61
31758828 2019
47
Development of immunochromatographic device as a point-of-care tool for serodiagnosis of human strongyloidiasis cases. 61
31758442 2019
48
A single dose of ivermectin is sufficient for strongyloidiasis. 61
31558377 2019
49
Utility of PCR in Patients with Strongyloides stercoralis and HTLV-1 Coinfection in French Guiana. 61
31436152 2019
50
Prevalence and risk factors of Strongyloides stercoralis infection among Orang Asli schoolchildren: new insights into the epidemiology, transmission and diagnosis of strongyloidiasis in Malaysia. 61
31303180 2019

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 TGFB1 IL5 IL3 IL13 IGHE IFNG
2
Show member pathways
13.6 TGFB1 IL5 IL3 IL13 IFNG CD40LG
3
Show member pathways
13.45 TGFB1 IL5 IL3 IL13 IFNG CD4
4
Show member pathways
13.33 TGFB1 IL5 IL3 IL13 CD40LG CD4
5
Show member pathways
13.22 TGFB1 IL5 IL3 IL13 CD40LG CD4
6
Show member pathways
13.17 TGFB1 IL5 IL3 IL13 IGHE IFNG
7 12.77 TGFB1 IL5 IL3 IL13 IFNG
8
Show member pathways
12.58 IGHE IFNG CD79A CD40LG CD4
9
Show member pathways
12.54 TGFB1 IL5 IFNG CD40LG CD4
10
Show member pathways
12.53 TGFB1 IL5 IL13 IFNG CD4
11
Show member pathways
12.51 IL5 IL3 IL13 IGHE CD79A
12
Show member pathways
12.5 TGFB1 IL5 IL3 IL13 IFNG CD40LG
13 12.48 IL3 IFNG CD79A CD40LG
14
Show member pathways
12.28 IL5 IL3 IL13 IFNG
15
Show member pathways
12.27 IL5 IL13 IFNG CCL11
16
Show member pathways
12.19 TGFB1 IL5 IL3 IL13 IFNG
17 11.91 TGFB1 IL13 IGHE CCL11
18 11.86 TGFB1 IL3 IFNG
19 11.83 IL5 IL3 IFNG CD79A CD4
20 11.81 IL5 IL3 CD7 CD4
21 11.74 IL5 IL13 IFNG
22 11.69 TGFB1 IFNG CD4
23
Show member pathways
11.68 IL5 IL3 IFNG CD40LG
24 11.63 TGFB1 IL13 IFNG CCL11
25 11.56 TGFB1 IL5 IL13 CCL11
26 11.56 IL5 IL13 IFNG CD7 CD4
27 11.53 IL5 IGHE CD40LG CCL11
28 11.5 TGFB1 IFNG CD40LG
29 11.36 CD79A CD40LG CD4
30 11.26 IL5 IFNG CD40LG
31 11.24 IL5 IL13 IFNG
32 11.12 IL5 IL13 IFNG
33 11.07 TGFB1 IL13 IFNG CD4
34 11.02 IL5 IL13 IFNG CD4 CCL11
35 10.92 TGFB1 IL5 IL3 IL13 CD40LG CCL11
36 10.56 TGFB1 IL5 IL3 IL13 IFNG CD4

GO Terms for Strongyloidiasis

Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 TGFB1 LGALS3BP IL5 IL3 IL13 IFNG
2 external side of plasma membrane GO:0009897 9.55 IL13 IGHE CD79A CD40LG CD4
3 extracellular region GO:0005576 9.32 TGFB1 LGALS3BP IL5 IL3 IL13 IGHE

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.8 IFNG CD79A CD7 CD4
2 positive regulation of cell proliferation GO:0008284 9.8 TGFB1 IL5 IL3 IFNG EPGN
3 MAPK cascade GO:0000165 9.73 TGFB1 IL5 IL3 EPGN
4 inflammatory response GO:0006954 9.65 TGFB1 IL5 IL13 CD40LG CCL11
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL3 IL13 IFNG
6 response to vitamin D GO:0033280 9.51 TGFB1 CD4
7 T cell activation GO:0042110 9.5 TGFB1 CD7 CD4
8 cytokine-mediated signaling pathway GO:0019221 9.5 TGFB1 IL5 IL3 IL13 IGHE CD4
9 regulation of regulatory T cell differentiation GO:0045589 9.48 TGFB1 IFNG
10 negative regulation of interleukin-17 production GO:0032700 9.46 TGFB1 IFNG
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 TGFB1 IL5 IL3 CD4
12 immune response GO:0006955 9.28 IL5 IL3 IL13 IGHE IFNG CD7

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 TGFB1 IL5 IL3 EPGN
2 cytokine activity GO:0005125 9.17 TGFB1 IL5 IL3 IL13 IFNG CD40LG

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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