MCID: STR008
MIFTS: 55

Strongyloidiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 77 54 60 56 45 15 17 74 3
Disseminated Strongyloidiasis 12 74
Anguilluliasis 60 74
Infection by Strongyloides 12
Threadworm Infection 54
Anguillulosis 60
Enterobiasis 74

Characteristics:

Orphanet epidemiological data:

60
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD9CM 36 127.2
MeSH 45 D013322
NCIt 51 C128398
SNOMED-CT 69 1214006
ICD10 34 B78 B78.7 B78.9
MESH via Orphanet 46 D013322
ICD10 via Orphanet 35 B78.0 B78.1 B78.7 more
UMLS via Orphanet 75 C0038463 C0085810
Orphanet 60 ORPHA76

Summaries for Strongyloidiasis

NIH Rare Diseases : 54 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin. Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to schistosomiasis and giardiasis, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

CDC : 3  

Wikipedia : 77 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 schistosomiasis 30.5 IFNG IL13 IL5
2 giardiasis 30.2 CD79A TGFB1
3 enterobiasis 30.1 IL13 IL5
4 paragonimiasis 30.0 IL13 IL5
5 common variable immunodeficiency 30.0 CD79A IFNG IL5
6 intestinal schistosomiasis 30.0 IL13 IL5
7 pneumonia 29.9 CCL11 IL13 IL5
8 filariasis 29.8 IFNG IL5
9 cryptosporidiosis 29.8 CCL11 CD79A
10 asthma 29.8 CCL11 IFNG IL13 IL5
11 pulmonary disease, chronic obstructive 29.8 CCL11 IL13 TGFB1
12 folliculitis 29.6 CCL11 IFNG IL5
13 inflammatory bowel disease 29.6 IFNG IL13 TGFB1
14 dermatitis 29.3 CCL11 IFNG IL13 IL5
15 cow milk allergy 10.3 CD79A IL5
16 milk allergy 10.3 CD79A IL5
17 allergic contact dermatitis 10.3 IFNG IL5
18 cytokine deficiency 10.3 IL13 IL5
19 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL13 IL5
20 respiratory syncytial virus infectious disease 10.3 IL13 IL5
21 inflammatory bowel disease 4 10.3 IL13 IL5
22 eosinophilic fasciitis 10.3 IFNG IL5
23 apple allergy 10.3 IL13 IL5
24 cephalosporin allergy 10.3 IFNG IL5
25 ascaris lumbricoides infection 10.3 IL13 IL5
26 meningitis 10.3
27 scleritis 10.2 IFNG IL5
28 latex allergy 10.2 IL13 IL5
29 sporotrichosis 10.2 CD79A IFNG
30 atopic keratoconjunctivitis 10.2 IFNG IL5
31 chronic tic disorder 10.2 IL13 IL5
32 norwegian scabies 10.2 IL5 TGFB1
33 nephrotic syndrome 10.2
34 pemphigoid gestationis 10.2 CCL11 IL5
35 chronic graft versus host disease 10.2 CD79A IFNG
36 chronic meningitis 10.2 CCL11 IL5
37 multicentric castleman disease 10.2 IFNG IL5
38 african tick-bite fever 10.2 IFNG IL13
39 microscopic colitis 10.2 CD79A IFNG
40 tuberculoid leprosy 10.2 IFNG TGFB1
41 penicillin allergy 10.2 IFNG IL13
42 eosinophilic gastroenteritis 10.2 CCL11 IL5
43 toxic oil syndrome 10.2 IFNG IL5
44 pollen allergy 10.2 IL13 IL5
45 lymphoma 10.2
46 purpura 10.2
47 chronic eosinophilic pneumonia 10.2 CCL11 IL5
48 chronic active epstein-barr virus infection 10.2 IFNG TGFB1
49 kimura disease 10.2 CCL11 IL5
50 orofacial granulomatosis 10.2 CD79A IFNG

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL11 CD53 CD79A IFNG IL13 IL5
2 immune system MP:0005387 9.5 CCL11 CD53 CD79A IFNG IL13 IL5
3 respiratory system MP:0005388 9.02 CCL11 IFNG IL13 IL5 TGFB1

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 3,Not Applicable 54965-21-8 2082
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
4
Azithromycin Approved Phase 3 83905-01-5 55185 447043
5 Anti-Infective Agents Phase 3,Not Applicable
6 Antiparasitic Agents Phase 3,Not Applicable
7 Antiprotozoal Agents Phase 3,Not Applicable
8 Antimitotic Agents Phase 3,Not Applicable
9 Anthelmintics Phase 3,Not Applicable
10 Anti-Bacterial Agents Phase 3
11 Lipoxygenase Inhibitors Phase 3
12
Mebendazole Approved, Vet_approved Not Applicable 31431-39-7 4030
13
Formaldehyde Approved, Vet_approved 50-00-0 712
14 Ether
15 Disinfectants

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
4 Treatment of Strongyloides Infection Recruiting NCT03605758 Phase 3 Ivermectin
5 Management of Soil-transmitted Helminthiasis and Strongyloidiasis Unknown status NCT01308268 Not Applicable Ivermectin + Albendazole
6 Host Response to Infection and Treatment in Lymphatic Filarial Disease in India Completed NCT00342576
7 Study of Patients With Strongyloides Stercoralis Infection Completed NCT00001245
8 Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections Completed NCT00207753 Not Applicable albendazole vs. combined albendazole/ivermectin treatment
9 The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989 Not Applicable
10 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
11 Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

42
Skin, Testes, T Cells, Kidney, Colon, Heart, Small Intestine

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 784)
# Title Authors Year
1
Accuracy of Urine and Serum Assays for the Diagnosis of Strongyloidiasis by Three Enzyme-Linked Immunosorbent Assay Protocols. ( 30398144 )
2019
2
Case Report: Central Nervous System Strongyloidiasis: Two Cases Diagnosed Antemortem. ( 30457095 )
2019
3
Donor-derived strongyloidiasis in a Saudi pediatric kidney transplant recipient: A case report and mini-review. ( 30578622 )
2019
4
Diagnostic update for an unusual case: recurrent strongyloidiasis. ( 30636686 )
2019
5
Prevalence of strongyloidiasis and schistosomiasis among migrants: a systematic review and meta-analysis. ( 30683241 )
2019
6
Strongyloidiasis and schistosomiasis: lessons from migrants' data. ( 30683227 )
2019
7
Strongyloidiasis: A Neglected Tropical Disease. ( 30712758 )
2019
8
Lethal strongyloidiasis - Diagnostic and forensic issues. ( 30738288 )
2019
9
Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis. ( 30759812 )
2019
10
Comparison of ELISA and PCR of the 18S rRNA gene for detection of human strongyloidiasis using serum sample. ( 30773081 )
2019
11
Production of recombinant 14-3-3 protein and determination of its immunogenicity for application in serodiagnosis of strongyloidiasis. ( 30856271 )
2019
12
Severe Strongyloidiasis in Solid Organ Transplant Recipients: Should We Preventively Treat the Recipient, the Donor, or Both? ( 29363441 )
2018
13
Molecular diagnosis of strongyloidiasis in a population of an endemic area through nested-PCR. ( 29564068 )
2018
14
Molecular and Immnune Diagnosis: Further Testing for Human Strongyloidiasis. ( 29934882 )
2018
15
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
16
Strongyloidiasis Outside Endemic Areas: Long-term Parasitological and Clinical Follow-up After Ivermectin Treatment. ( 29360939 )
2018
17
Identification and Preliminary Evaluation of a Novel Recombinant Protein for Serodiagnosis of Strongyloidiasis. ( 29436335 )
2018
18
Chronic strongyloidiasis with recurrent asthma exacerbations and steroid-associated 'hives'. ( 29348277 )
2018
19
Worming Your Way Through the Gastrointestinal Tract: A Case of Strongyloidiasis. ( 29505750 )
2018
20
Pulmonary strongyloidiasis causing septic shock in a patient with Crohn's disease. ( 29977759 )
2018
21
Periumbilical purpura: dermatoscopic findings in disseminated strongyloidiasis. ( 29740812 )
2018
22
Metaperiodate deglycosylation of Strongyloides venezuelensis larvae: Immunochemical characterization and antigen production for human strongyloidiasis diagnosis. ( 29454735 )
2018
23
Fatal pancytopenia due to albendazole treatment for strongyloidiasis. ( 29942764 )
2018
24
Detection of immune complexes and evaluation of alcoholic individuals' serological profile in the diagnosis of strongyloidiasis. ( 29933043 )
2018
25
Management of severe strongyloidiasis attended at reference centers in Spain. ( 29474356 )
2018
26
Human Strongyloidiasis in Hawaii: A Retrospective Review of Enzyme-Linked Immunosorbent Assay Serodiagnostic Testing. ( 29943712 )
2018
27
Is Ivermectin Ineffective for Strongyloidiasis? ( 29788131 )
2018
28
Image Gallery: Periumbilical purpura: aA dermatological clue for disseminated strongyloidiasis. ( 29441550 )
2018
29
Schistosomiasis and Strongyloidiasis Recommendations for Solid-Organ Transplant Recipients and Donors. ( 29381575 )
2018
30
Strongyloidiasis and Culture-Negative Suppurative Meningitis, Japan, 1993-2015. ( 30457540 )
2018
31
Diagnostic performance of urinary IgG antibody detection: A novel approach for population screening of strongyloidiasis. ( 29985913 )
2018
32
OCCASIONAL DIGESTIVE HEMORRHAGE IN CHILDREN DUE TO STRONGYLOIDIASIS: IMPORTANCE OF PARASITOLOGIC TESTING. ( 30066826 )
2018
33
Investigations for the Possible Use of a Monoclonal Antibody Produced against Strongyloides ratti Antigen as an Immunodiagnostic Reagent for Active Strongyloidiasis. ( 30069204 )
2018
34
Strongyloidiasis in humans: diagnostic efficacy of four conventional methods and real-time polymerase chain reaction. ( 30133633 )
2018
35
Strongyloidiasis Presenting as Yellowish Nodules in Colonoscopy of an Immunocompetent Patient. ( 30157619 )
2018
36
Enterobius vermicularis infection mimicking strongyloidiasis: A case report. ( 30190233 )
2018
37
Case Report: Ivermectin and Albendazole Plasma Concentrations in a Patient with Disseminated Strongyloidiasis on Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy. ( 30226142 )
2018
38
Pulmonary strongyloidiasis presenting micronodules on chest computed tomography. ( 30233896 )
2018
39
A case of chronic strongyloidiasis diagnosed by histopathological study. ( 30261269 )
2018
40
The Health Effects of Strongyloidiasis on Pregnant Women and Children: A Systematic Literature Review. ( 30274446 )
2018
41
Argument for Inclusion of Strongyloidiasis in the Australian National Notifiable Disease List. ( 30274457 )
2018
42
Paediatric Strongyloidiasis in Central Australia. ( 30274460 )
2018
43
Donor-derived strongyloidiasis after organ transplantation in Norway. ( 30295406 )
2018
44
Severe strongyloidiasis and systemic vasculitis: comorbidity, association or both? Case-based review. ( 30353268 )
2018
45
Hypermetabolic Diffuse Proximal Small Bowel Wall Thickening on Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography? Consider Strongyloidiasis among the Differentials. ( 30386068 )
2018
46
Fatal strongyloidiasis after corticosteroid therapy for presumed chronic obstructive pulmonary disease. ( 30425838 )
2018
47
Gastroduodenal involvement in disseminated strongyloidiasis. ( 30483566 )
2018
48
Challenge in the diagnosis of pulmonary strongyloidiasis. ( 30569952 )
2018
49
Disseminated Strongyloidiasis. ( 30665485 )
2018
50
Effectiveness of Screening and Treatment Approaches for Schistosomiasis and Strongyloidiasis in Newly-Arrived Migrants from Endemic Countries in the EU/EEA: A Systematic Review. ( 30577567 )
2018

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 CCL11 CD53 CD79A IFNG IL13 IL5
2
Show member pathways
13.27 CCL11 IFNG IL13 IL5 TGFB1
3
Show member pathways
13.1 CCL11 IFNG IL13 IL5 TGFB1
4
Show member pathways
12.61 CCL11 IFNG IL13 IL5 TGFB1
5 12.59 IFNG IL13 IL5 TGFB1
6
Show member pathways
12.38 IFNG IL13 IL5 TGFB1
7
Show member pathways
12.2 IFNG IL5 TGFB1
8
Show member pathways
12.16 IFNG IL13 IL5
9
Show member pathways
12.09 CCL11 IFNG IL13 IL5
10
Show member pathways
12.03 IFNG IL13 IL5 TGFB1
11 11.8 CD79A IFNG IL5
12 11.78 CCL11 IL13 TGFB1
13
Show member pathways
11.73 CCL11 IFNG IL13 IL5 TGFB1
14 11.6 IFNG IL13 IL5
15 11.57 IFNG IL13 IL5
16 11.41 CCL11 IFNG IL13 TGFB1
17 11.32 IFNG TGFB1
18 11.3 IFNG TGFB1
19 11.26 CCL11 IL13 IL5 TGFB1
20 11.12 IFNG IL5
21 11.11 IFNG IL13 IL5
22 11.03 IFNG IL13 TGFB1
23 10.99 CCL11 IL13 IL5
24 10.96 IFNG IL13 IL5
25 10.92 CCL11 IFNG IL13 IL5
26 10.78 CCL11 IL13 IL5 TGFB1
27 10.39 IFNG IL13 IL5 TGFB1

GO Terms for Strongyloidiasis

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.67 CD53 CD79A IFNG
2 immune response GO:0006955 9.67 CCL11 IFNG IL13 IL5
3 extrinsic apoptotic signaling pathway GO:0097191 9.51 IFNG TGFB1
4 positive regulation of B cell proliferation GO:0030890 9.48 IL13 IL5
5 positive regulation of protein secretion GO:0050714 9.46 IL13 TGFB1
6 inflammatory response GO:0006954 9.46 CCL11 IL13 IL5 TGFB1
7 response to radiation GO:0009314 9.43 CCL11 TGFB1
8 positive regulation of protein complex assembly GO:0031334 9.4 IFNG TGFB1
9 regulation of regulatory T cell differentiation GO:0045589 9.32 IFNG TGFB1
10 negative regulation of interleukin-17 production GO:0032700 9.26 IFNG TGFB1
11 cytokine-mediated signaling pathway GO:0019221 9.26 CCL11 IL13 IL5 TGFB1
12 regulation of signaling receptor activity GO:0010469 9.02 CCL11 IFNG IL13 IL5 TGFB1

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.61 CCL11 CD53 CD79A IFNG IL13 IL5
2 cytokine activity GO:0005125 9.02 CCL11 IFNG IL13 IL5 TGFB1

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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