MCID: STR008
MIFTS: 51

Strongyloidiasis

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Strongyloidiasis

MalaCards integrated aliases for Strongyloidiasis:

Name: Strongyloidiasis 12 74 52 58 54 3 43 15 17 71 32
Disseminated Strongyloidiasis 12 71 32
Anguilluliasis 58 71
Infection by Strongyloides 12
Threadworm Infection 52
Anguillulosis 58
Enterobiasis 71

Characteristics:

Orphanet epidemiological data:

58
strongyloidiasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10955
ICD9CM 34 127.2
MeSH 43 D013322
NCIt 49 C128398
SNOMED-CT 67 1214006
ICD10 32 B78 B78.7 B78.9
MESH via Orphanet 44 D013322
ICD10 via Orphanet 33 B78.0 B78.1 B78.7 more
UMLS via Orphanet 72 C0038463 C0085810
Orphanet 58 ORPHA76
UMLS 71 C0038463 C0085810 C0086227 more

Summaries for Strongyloidiasis

CDC : 3 Strongyloidiasis is a disease caused by a nematode, or a roundworm, in the genus Strongyloides. Though there are over 40 species within this genus that can infect birds, reptiles, amphibians, livestock and other primates, Strongyloides stercoralis is the primary species that accounts for human disease. It sometimes infects primates, dogs and cats, and some dog and primate infecting strains have been shown to be capable of causing human infection. We do not know if cat-infecting strains can infect humans or not. The larvae are small; the longest reach about 600 µm in length-making them very difficult to see with the naked eye.

MalaCards based summary : Strongyloidiasis, also known as disseminated strongyloidiasis, is related to meningitis and schistosomiasis, and has symptoms including fever and pruritus. An important gene associated with Strongyloidiasis is IL5 (Interleukin 5), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. The drugs Albendazole and Diethylcarbamazine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis.

NIH Rare Diseases : 52 Strongyloidiasis is a parasitic disease caused by the roundworm Strongyloides stercoralis (S. stercoralis). People catch the infection when they come in contact with soil contaminated with the worms. While there are often no symptoms, abdominal pain, cough, diarrhea, rash, unintentional weight loss and vomiting may occur. The infection is treated with anti-worm medications such as ivermectin . Strongyloidiasis is found in tropical and subtropical areas, but can also be found in temperate regions, including the southern United States.

Wikipedia : 74 Strongyloidiasis is a human parasitic disease caused by the nematode called Strongyloides stercoralis,... more...

Related Diseases for Strongyloidiasis

Diseases related to Strongyloidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 395)
# Related Disease Score Top Affiliating Genes
1 meningitis 31.2 IL5 IL13 IFNG
2 schistosomiasis 30.9 IL5 IL13 IGHE IFNG
3 urticaria 30.9 IL5 IL13 IGHE
4 filariasis 30.7 LGALS3BP IL5 IGHE IFNG
5 hypereosinophilic syndrome 30.6 IL5 IL3 IL13 IGHE IFNG CCL11
6 toxocariasis 30.6 IL5 IGHE EPGN
7 diarrhea 30.5 TGFB1 IL5 IL3 IL13 IFNG
8 respiratory failure 30.4 IL5 IL13 IGHE CD4 CCL11
9 cystoisosporiasis 30.3 MT-CO1 CD4
10 lung disease 30.3 TGFB1 IL5 IL13 IFNG
11 t-cell lymphoblastic leukemia/lymphoma 30.3 IL5 IL3 CD7 CD4
12 trichuriasis 30.3 STH IL13 EPGN
13 norwegian scabies 30.2 IL5 CD4
14 allergic bronchopulmonary aspergillosis 30.2 IL5 IGHE IFNG
15 dermatitis 30.2 IL5 IL13 IGHE IFNG CCL11
16 necatoriasis 30.2 IL5 EPGN
17 intestinal tuberculosis 30.1 IFNG CD4
18 nocardiosis 30.1 IFNG CD4
19 giardiasis 30.1 TGFB1 STH CD79A CD4
20 bronchitis 30.1 IL5 IL13 IGHE CCL11
21 ancylostomiasis 30.1 MT-CO1 EPGN
22 drug allergy 30.1 IL5 IGHE CD4
23 leishmaniasis 30.1 TGFB1 IL5 IL13 IFNG
24 echinococcosis 30.1 MT-CO1 IL5 IGHE IFNG
25 immune deficiency disease 30.0 IL13 IFNG CD79A CD4
26 loiasis 30.0 STH IL5 IL13
27 bronchiolitis obliterans 30.0 TGFB1 IL13 IFNG
28 cryptococcosis 30.0 IL13 IFNG CD4
29 cryptosporidiosis 30.0 IFNG CD79A CD4 CCL11
30 ige responsiveness, atopic 30.0 IL5 IL13 IGHE IFNG
31 chagas disease 30.0 TGFB1 IFNG CD4
32 ascaris lumbricoides infection 29.9 STH IL5 IL13 IFNG EPGN
33 lung abscess 29.9 IFNG CD4
34 autoimmune disease 29.9 TGFB1 IL5 IL13 IFNG CD79A
35 pneumonia 29.9 IL5 IL13 IFNG CCL11
36 bronchiolitis 29.9 IL5 IL13 IFNG CCL11
37 pulmonary disease, chronic obstructive 29.9 TGFB1 IL5 IL13 CD4 CCL11
38 enterobiasis 29.9 STH MT-CO1 EPGN
39 toxoplasmosis 29.8 TGFB1 IL5 IFNG CD79A
40 folliculitis 29.8 IL5 IFNG CD4 CCL11
41 gastroenteritis 29.8 IL5 IL3 IFNG CCL11
42 cystic echinococcosis 29.7 MT-CO1 IGHE IFNG
43 pancytopenia 29.7 IL3 IFNG CD7 CD4
44 fascioliasis 29.7 MT-CO1 IFNG EPGN
45 conjunctivitis 29.7 IL5 IL13 IGHE IFNG CCL11
46 cysticercosis 29.6 STH MT-CO1 IGHE CD4
47 trichinosis 29.5 IL5 IL3 IL13 CD4
48 taeniasis 29.4 STH MT-CO1 CD4
49 t-cell adult acute lymphocytic leukemia 29.4 LTV1 HBZ CD7 CD4
50 inflammatory bowel disease 29.2 TGFB1 IL5 IL3 IL13 IFNG CCL11

Graphical network of the top 20 diseases related to Strongyloidiasis:



Diseases related to Strongyloidiasis

Symptoms & Phenotypes for Strongyloidiasis

UMLS symptoms related to Strongyloidiasis:


fever, pruritus

MGI Mouse Phenotypes related to Strongyloidiasis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 CCL11 CD4 CD7 CD79A EPGN HBZ
2 immune system MP:0005387 9.36 CCL11 CD4 CD7 CD79A EPGN IFNG

Drugs & Therapeutics for Strongyloidiasis

Drugs for Strongyloidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Albendazole Approved, Vet_approved Phase 3 54965-21-8 2082
2
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 3 90-89-1 3052
3
Azithromycin Approved Phase 3 83905-01-5 447043 55185
4
Ivermectin Approved, Investigational, Vet_approved Phase 2, Phase 3 70288-86-7 6474909
5
Nitazoxanide Approved, Investigational, Vet_approved Phase 2, Phase 3 55981-09-4 41684
6 Antiprotozoal Agents Phase 3
7 Tubulin Modulators Phase 3
8 Antimitotic Agents Phase 3
9 Anti-Bacterial Agents Phase 3
10 Antiparasitic Agents Phase 2, Phase 3
11 Anti-Infective Agents Phase 2, Phase 3
12 Anthelmintics Phase 2
13 Milbemycin Phase 2
14
Formaldehyde Approved, Vet_approved 50-00-0 712
15
Mebendazole Approved, Vet_approved 31431-39-7 4030
16 Disinfectants
17 Ether

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Randomized, Open-label, Multi Centre Phase III Clinical Trial on Multiple Versus Single Dose of Ivermectin for the Treatment of Strongyloidiasis Completed NCT01570504 Phase 3 Ivermectin
2 Efficacy and Safety of Ivermectin Versus Albendazole for Chronic Strongyloidiasis Completed NCT00765024 Phase 3 Ivermectin;ivermectin;Albendazole
3 A Cluster Randomised Trial of the Safety of Co-Administration of IDA (Ivermectin, Diethylcarbamazine and Albendazole) & Azithromycin for Integrated Treatment of Neglected Tropical Diseases Completed NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
4 A Comparative Study of Two Regimens of Ivermectin for the Treatment of Strongyloides Stercoralis Infection Recruiting NCT03605758 Phase 3 Ivermectin
5 Clinical Trial Evaluating Safety and Efficacy of Ivermectin and Nitazoxanide Combination as Adjuvant Therapy in COVID-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope Not yet recruiting NCT04360356 Phase 2, Phase 3
6 Efficacy, Safety and Pharmacokinetics of Ascending Dosages of Moxidectin Alone and in Comparison to Ivermectin Against Strongyloidiasis Stercoralis in Adults: a Randomized Controlled Trial Enrolling by invitation NCT04056325 Phase 2 Moxidectin;Ivermectin;Placebo oral tablet
7 Multicenter, Double-blind, Randomized, Placebo-controlled Study to Assess the Efficacy, Safety and Tolerability of Ivermectin in Mild Virus-positive Subjects (SARS-CoV)-2 With or Without Symptoms Not yet recruiting NCT04407507 Phase 2 Ivermectin;Placebo
8 Community-based Approach for the Management of Soil-transmitted Helminthiasis in General and Strongyloidiasis in Particular in a Highly Endemic Area Unknown status NCT01308268 Ivermectin + Albendazole
9 Study of Patients With Known or Suspected Infection With Strongyloides Stercoralis Completed NCT00001245
10 Host Response to Infection and Treatment in Lymphatic Filarial Disease Strongyloidiasis in India Completed NCT00342576
11 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
12 Efficacy and Nutritional Assessment Following Albendazole and Combined Albendazole/Ivermectin Treatment for Intestinal Helminth Infections in Rural Guatemalan Schoolchildren Completed NCT00207753 albendazole vs. combined albendazole/ivermectin treatment
13 The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands Completed NCT01080989
14 Study of Patients With Parasitic Infections of the Gastrointestinal Tract Terminated NCT00001162

Search NIH Clinical Center for Strongyloidiasis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Albendazole
Ivermectin
Mebendazole
Pyrantel
Pyrantel Pamoate
Thiabendazole

Cochrane evidence based reviews: strongyloidiasis

Genetic Tests for Strongyloidiasis

Anatomical Context for Strongyloidiasis

MalaCards organs/tissues related to Strongyloidiasis:

40
Testes, Skin, T Cells, Lung, Eye, Kidney, Small Intestine

Publications for Strongyloidiasis

Articles related to Strongyloidiasis:

(show top 50) (show all 1897)
# Title Authors PMID Year
1
Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to Strongyloides stercoralis antigen. 61 54
19513105 2009
2
Eosinophil-selective mediators in human strongyloidiasis. 61 54
16879311 2006
3
The mutual influence of nematode infection and allergy. 61 54
16210900 2006
4
Strongyloides ratti antigenic components recognized by IgE antibodies in immunoblotting as an additional tool for improving the immunodiagnosis in human strongyloidiasis. 54 61
15057354 2004
5
Heterologous antigen extract in ELISA for the detection of human IgE anti-Strongyloides stercoralis. 61 54
14743666 2003
6
Immunoglobulin-E and anti-IgE treatment in lung disease. 54 61
11980283 2001
7
A three years follow-up of total serum IgE levels in three patients treated for strongyloidiasis. 61 54
11802274 2001
8
Influence of human T-cell lymphocytotropic virus type 1 infection on serologic and skin tests for strongyloidiasis. 61 54
11716123 2001
9
HTLV-1 decreases Th2 type of immune response in patients with strongyloidiasis. 54 61
11589779 2001
10
L3 antigen-specific antibody isotype responses in human strongyloidiasis: correlations with larval output. 61 54
10587378 1999
11
Differentially enhanced cytokine gene expression in CD4+ and CD8+ T cells in mesenteric lymph nodes in rats infected with Nippostrongylus brasiliensis. 54 61
10610496 1999
12
Interferon-gamma and interleukin-4 responses in relation to serum IgE levels in persons infected with human T lymphotropic virus type I and Strongyloides stercoralis. 54 61
9815251 1998
13
Humoral responses in human strongyloidiasis: correlations with infection chronicity. 54 61
9463683 1997
14
Total serum IgE and parasite-specific IgG and IgA antibodies in human strongyloidiasis. 54 61
8115797 1993
15
Strongyloides stercoralis hyperinfection in a carrier of HTLV-I virus with evidence of selective immunosuppression. 61 54
1543206 1992
16
Regulatory T cell expansion resolves after effective strongyloidiasis treatment in subjects with HTLV-1 co-infection. 61
32120049 2020
17
Diagnostic update for an unusual case: recurrent strongyloidiasis. 61
30636686 2020
18
Strongyloides stercoralis hyperinfection syndrome presenting as mechanical ileus after short-course oral steroids for chronic obstructive pulmonary disease (COPD) exacerbation. 61
32087332 2020
19
The Global Prevalence of Strongyloides stercoralis Infection. 61
32545787 2020
20
Autochthonous Human and Canine Strongyloides stercoralis Infection in Europe: Report of a Human Case in An Italian Teen and Systematic Review of the Literature. 61
32503315 2020
21
Case Report: Incidentally Discovered Strongyloides stercoralis Infection after Urinary Diversion. 61
32228779 2020
22
Prevalence of Intestinal Parasites in a Low-Income Texas Community. 61
32207401 2020
23
Phylogenetic relationships of Strongyloides species in carnivore hosts. 61
32502520 2020
24
Serological assays for the diagnosis of Strongyloides stercoralis infection: a systematic review and meta-analysis of diagnostic test accuracy. 61
32052848 2020
25
A Case-Control Study on the Association Between Intestinal Helminth Infections and Treatment Failure in Patients With Cutaneous Leishmaniasis. 61
32494582 2020
26
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
27
Performance of two serodiagnostic tests for loiasis in a Non-Endemic area. 61
32453734 2020
28
Hospitalization for Chagas disease, dengue, filariasis, leishmaniasis, schistosomiasis, strongyloidiasis, and Taenia solium taeniasis/cysticercosis, Italy, 2011-2016. 61
32418191 2020
29
Fatal Strongyloides stercoralis hyperinfection syndrome in an alcoholic diabetic patient from México 61
32463606 2020
30
Prevalence and risk factors of strongyloidiasis in patients with systemic lupus erythematosus in Southern Thailand. 61
32183590 2020
31
Should We Screen HIV-Positive Migrants for Strongyloidiasis? 61
32443596 2020
32
A Cross-Sectional Study of Seroprevalence of Strongyloidiasis in Pregnant Women (Peruvian Amazon Basin). 61
32375325 2020
33
Strongyloides stercoralis Hyper infection Syndrome. 61
32419745 2020
34
Strongyloides stercoralis seropositivity is not associated with increased symptoms in a remote Aboriginal community. 61
32372503 2020
35
Cost-effectiveness of different strategies for screening and treatment of Strongyloides stercoralis in migrants from endemic countries to the European Union. 61
32461226 2020
36
Genomic studies on Strongyloides stercoralis in northern and western Thailand. 61
32404172 2020
37
Integrating testing for chronic strongyloidiasis within the Indigenous adult preventive health assessment system in endemic communities in the Northern Territory, Australia: An intervention study. 61
32401755 2020
38
Update on the major imported helminth infections in travelers and migrants. 61
32250168 2020
39
Opportunistic tropical infections in immunosuppressed patients. 61
32299676 2020
40
The Strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review. 61
32282827 2020
41
Transplant-related strongyloidiasis in solid organ transplant recipients in Saudi Arabia and the Gulf Cooperation Council countries. 61
31982623 2020
42
Parasitological and immunological aspects of oral and subcutaneous prednisolone treatment in rats experimentally infected with Strongyloides venezuelensis. 61
31958413 2020
43
Strongyloides Screening in Heart Transplant Candidates. 61
32465869 2020
44
Infection by Strongyloides stercoralis in immigrants with Chagas disease: evaluation of eosinophilia as screening method in primary care. 61
31845476 2020
45
Health of Special Immigrant Visa holders from Iraq and Afghanistan after arrival into the United States using Domestic Medical Examination data, 2014-2016: A cross-sectional analysis. 61
32231361 2020
46
[Recommendations for the screening for infectious diseases, mental health, and female genital mutilation in immigrant patients seen in Primary Care]. 61
31029458 2020
47
Imported Infections in Rural Mid-West United States - A Report from a Tertiary Care Center. 61
32308221 2020
48
Alcohol consumption alters anti-Strongyloides stercoralis antibodies production. 61
31902530 2020
49
Strongyloidiasis screening in migrants living in Spain: systematic review and meta-analysis. 61
31758828 2020
50
Development of immunochromatographic device as a point-of-care tool for serodiagnosis of human strongyloidiasis cases. 61
31758442 2020

Variations for Strongyloidiasis

Expression for Strongyloidiasis

Search GEO for disease gene expression data for Strongyloidiasis.

Pathways for Strongyloidiasis

Pathways related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.43 TGFB1 IL5 IL3 IL13 IFNG CD4
2
Show member pathways
13.19 TGFB1 IL5 IL3 IL13 IGHE IFNG
3
Show member pathways
13.18 TGFB1 IL5 IL3 IL13 CD4 CCL11
4 12.72 TGFB1 IL5 IL3 IL13 IFNG
5
Show member pathways
12.65 TGFB1 IL5 IL3 IL13 IFNG CD4
6
Show member pathways
12.49 TGFB1 IL5 IL13 IFNG CD4
7
Show member pathways
12.48 TGFB1 IL5 IFNG CD4
8
Show member pathways
12.47 IL5 IL3 IL13 IGHE CD79A
9
Show member pathways
12.34 IL5 IL3 IL13 IFNG
10
Show member pathways
12.21 IL5 IL13 IFNG CCL11
11
Show member pathways
12.16 TGFB1 IL5 IL3 IL13 IFNG
12 11.87 TGFB1 IL13 IGHE CCL11
13 11.83 TGFB1 IL3 IFNG
14
Show member pathways
11.82 TGFB1 IFNG CD4
15 11.78 IL5 IL3 IFNG CD79A CD4
16
Show member pathways
11.75 TGFB1 IFNG CD4
17 11.75 IL5 IL3 CD7 CD4
18 11.69 IL5 IL13 IFNG
19
Show member pathways
11.65 IL5 IL3 IFNG
20 11.63 TGFB1 IFNG CD4
21 11.54 IL5 IGHE CCL11
22 11.53 TGFB1 IL5 IL13 CCL11
23 11.46 IL5 IL13 IFNG CD7 CD4
24 11.21 IL5 IL13 IFNG
25 11.09 IL5 IL13 IFNG
26 11.02 IL5 IL13 IFNG CD4 CCL11
27 11 TGFB1 IL13 IFNG CD4
28 10.91 TGFB1 IL5 IL3 IL13 CCL11
29 10.66 TGFB1 IL5 IL13
30 10.56 TGFB1 IL5 IL3 IL13 IFNG CD4

GO Terms for Strongyloidiasis

Cellular components related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 TGFB1 LGALS3BP IL5 IL3 IL13 IFNG
2 extracellular region GO:0005576 9.28 TGFB1 LGALS3BP IL5 IL3 IL13 IGHE
3 preribosome, small subunit precursor GO:0030688 9.16 RIOK2 LTV1

Biological processes related to Strongyloidiasis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 TGFB1 IL5 IL3 IFNG EPGN
2 MAPK cascade GO:0000165 9.73 TGFB1 IL5 IL3 EPGN
3 adaptive immune response GO:0002250 9.72 IGHE IFNG CD79A CD7 CD4
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL3 IL13 IFNG
5 cytokine-mediated signaling pathway GO:0019221 9.5 TGFB1 IL5 IL3 IL13 IGHE CD4
6 response to vitamin D GO:0033280 9.49 TGFB1 CD4
7 regulation of regulatory T cell differentiation GO:0045589 9.48 TGFB1 IFNG
8 negative regulation of interleukin-17 production GO:0032700 9.46 TGFB1 IFNG
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.46 TGFB1 IL5 IL3 CD4
10 T cell activation GO:0042110 9.43 TGFB1 CD7 CD4
11 immune response GO:0006955 9.23 IL5 IL3 IL13 IGHE IFNG CD7

Molecular functions related to Strongyloidiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 TGFB1 IL5 IL3 EPGN
2 cytokine activity GO:0005125 9.1 TGFB1 IL5 IL3 IL13 IFNG CCL11

Sources for Strongyloidiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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