MCID: STR021
MIFTS: 37

Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Struma Ovarii

MalaCards integrated aliases for Struma Ovarii:

Name: Struma Ovarii 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 44 D013330
NCIt 50 C7468
SNOMED-CT 68 24327009
UMLS 73 C0038478

Summaries for Struma Ovarii

Disease Ontology : 12 An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue.

MalaCards based summary : Struma Ovarii is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are VEGF Pathway (Tocris) and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Hormones, Hormone Substitutes, and Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and bone, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 76 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 34.0 NKX2-1 RET TG
2 benign struma ovarii 33.8 RET TG TSHR
3 thyroid cancer, nonmedullary, 1 31.1 BRAF NKX2-1
4 hyperthyroidism 30.8 TG TSHR
5 ovarian germ cell teratoma 30.6 NKX2-1 RET TG
6 thyroiditis 30.4 RET TG TSHR
7 mature teratoma 30.4 BRAF TG
8 adenoma 30.3 BRAF RET TSHR
9 thyroid cancer 30.2 BRAF NKX2-1 RET TG TSHR
10 graves disease 1 30.1 TG TSHR
11 papillary carcinoma 30.0 BRAF NKX2-1 RET TG TSHR
12 hypothyroidism 29.9 NKX2-1 RET TG TSHR
13 goiter 29.9 NKX2-1 TG TSHR
14 hashimoto thyroiditis 29.8 BRAF RET TG TSHR
15 papillary thyroid microcarcinoma 29.7 BRAF NKX2-1 TG TSHR
16 differentiated thyroid carcinoma 29.3 BRAF NKX2-1 RET TG TSHR
17 thyroid cancer, nonmedullary, 2 29.3 BRAF NKX2-1 RET TG TSHR
18 pseudo-meigs syndrome 10.7
19 graves' disease 10.7
20 teratoma 10.7
21 cystadenoma 10.5
22 ovarian cancer 10.4
23 cystic teratoma 10.3
24 endometriosis 10.3
25 adenocarcinoma 10.3
26 breast cancer 10.1
27 gonadoblastoma 10.1
28 ovarian cancer 1 10.1
29 ovarian brenner tumor 10.1
30 dermoid cyst 10.1
31 mucinous ovarian cystadenoma 10.1
32 ovarian cystadenoma 10.1
33 sertoli cell tumor 10.1
34 pituitary adenoma 10.1
35 cystadenofibroma 10.1
36 carcinoid syndrome 10.1
37 colloid adenoma 10.1 NKX2-1 TG
38 fetal adenoma 10.1 NKX2-1 TG
39 adenofibroma 10.1 BRAF MUC16
40 ovarian cystic teratoma 10.1 NKX2-1 TG
41 ovarian serous cystadenocarcinoma 10.0 BRAF MUC16
42 papillary adenocarcinoma 10.0 MUC16 NKX2-1
43 cowden disease 10.0 RET TG
44 neonatal hypothyroidism 10.0 TG TSHR
45 primary peritoneal carcinoma 10.0 MUC16 RET
46 endemic goiter 10.0 TG TSHR
47 postsurgical hypothyroidism 10.0 TG TSHR
48 hypertelorism 10.0 BRAF RET
49 nontoxic goiter 10.0 TG TSHR
50 toxic diffuse goiter 10.0 TG TSHR

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

MGI Mouse Phenotypes related to Struma Ovarii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 BRAF NKX2-1 RET TG TSHR
2 digestive/alimentary MP:0005381 9.62 BRAF NKX2-1 RET TG
3 limbs/digits/tail MP:0005371 9.46 BRAF RET TG TSHR
4 neoplasm MP:0002006 9.26 BRAF NKX2-1 RET TSHR
5 nervous system MP:0003631 9.02 BRAF NKX2-1 RET TG TSHR

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones, Hormone Substitutes, and Hormone Antagonists
2 Hormones
3 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

41
Thyroid, Ovary, Bone, Colon, Pituitary, Lung, T Cells

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 347)
# Title Authors Year
1
Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of<sup>131</sup>I scintigraphy and<sup>18</sup>F-FDG PET: case report and review of the literature. ( 29391043 )
2018
2
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
3
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
4
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
5
Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. ( 29455317 )
2018
6
Ovarian Combined Brenner Tumor, Mucinous Cystadenoma and Struma Ovarii: First Report of a Rare Combination. ( 30134344 )
2018
7
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. ( 30394923 )
2018
8
The Smallest Reported Malignant Struma Ovarii: A Case Report. ( 30483100 )
2018
9
Struma ovarii - ultrasound features of a rare tumor mimicking ovarian cancer. ( 30167590 )
2018
10
The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature. ( 30061934 )
2018
11
Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. ( 30087949 )
2018
12
An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report. ( 30196119 )
2018
13
Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review. ( 29264493 )
2017
14
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
15
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
16
A Rare Case: Struma Ovarii in a 14-Year-Old Girl. ( 28759301 )
2017
17
Papillary carcinoma in struma ovarii. ( 28251552 )
2017
18
Struma Ovarii with Pseudo-Meigs' Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma Case report and literature review. ( 28690899 )
2017
19
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
20
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017
21
Struma Ovarii With Hyperthyroidism. ( 28394842 )
2017
22
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
23
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
24
Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm. ( 30254866 )
2017
25
Erratum to: Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Non-Lactating Breast Simultaneously on Post-Ablation SPECT/CT for Papillary Thyroid Cancer. ( 28559950 )
2017
26
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
27
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
28
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
29
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
30
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
31
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation (131)I SPECT/CT for Papillary Thyroid Cancer. ( 27994692 )
2016
32
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. ( 27190936 )
2016
33
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. ( 27381498 )
2016
34
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. ( 27258816 )
2016
35
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
36
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. ( 27141138 )
2016
37
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
38
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
39
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
40
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015
41
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior. ( 26072948 )
2015
42
Pathology of Struma Ovarii: A Report of 96 Cases. ( 26374222 )
2015
43
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
44
Struma ovarii: management and follow-up of a rare ovarian tumour. ( 25640097 )
2015
45
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
46
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
47
Struma ovarii complicating pregnancy: a case report. ( 26411234 )
2015
48
Spinal metastasis from struma ovarii: case report and review of the literature. ( 25901242 )
2015
49
Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii. ( 26362194 )
2015
50
Sonographic and Pathologic Features of Struma Ovarii. ( 26149143 )
2015

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

Pathways related to Struma Ovarii according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.07 BRAF RET
2 10.79 BRAF TSHR
3 9.4 TG TSHR

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF NKX2-1
2 positive regulation of gene expression GO:0010628 9.13 BRAF NKX2-1 RET
3 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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