MCID: STR021
MIFTS: 37

Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Struma Ovarii

MalaCards integrated aliases for Struma Ovarii:

Name: Struma Ovarii 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 45 D013330
NCIt 51 C7468
SNOMED-CT 69 24327009
UMLS 74 C0038478

Summaries for Struma Ovarii

Disease Ontology : 12 An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue.

MalaCards based summary : Struma Ovarii is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are VEGF Pathway (Tocris) and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and t cells, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

Wikipedia : 77 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 34.0 NKX2-1 RET TG
2 benign struma ovarii 33.6 RET TG TSHR
3 thyroid cancer, nonmedullary, 1 31.2 BRAF NKX2-1
4 hyperthyroidism 30.8 TG TSHR
5 ovarian germ cell teratoma 30.6 NKX2-1 RET TG
6 graves disease 1 30.5 TG TSHR
7 ovarian serous cystadenocarcinoma 30.5 BRAF MUC16
8 mature teratoma 30.5 BRAF TG
9 graves' disease 30.4 TG TSHR
10 thyroiditis 30.3 RET TG TSHR
11 adenoma 30.1 BRAF RET TSHR
12 thyroid cancer 30.1 BRAF NKX2-1 RET TG TSHR
13 hashimoto thyroiditis 29.8 BRAF RET TG TSHR
14 goiter 29.8 NKX2-1 TG TSHR
15 hypothyroidism 29.6 NKX2-1 RET TG TSHR
16 papillary carcinoma 29.5 BRAF NKX2-1 RET TG TSHR
17 papillary thyroid microcarcinoma 29.4 BRAF NKX2-1 TG TSHR
18 differentiated thyroid carcinoma 28.9 BRAF NKX2-1 RET TG TSHR
19 thyroid cancer, nonmedullary, 2 28.9 BRAF NKX2-1 RET TG TSHR
20 pseudo-meigs syndrome 10.8
21 teratoma 10.7
22 cystadenoma 10.5
23 ovarian cancer 10.5
24 cystic teratoma 10.3
25 endometriosis 10.3
26 adenocarcinoma 10.3
27 breast cancer 10.2
28 gonadoblastoma 10.2
29 ovarian cancer 1 10.2
30 endometrial hyperplasia 10.2
31 dermoid cyst 10.2
32 mucinous ovarian cystadenoma 10.2
33 ovarian cystadenoma 10.2
34 sertoli cell tumor 10.2
35 pituitary adenoma 10.2
36 clear cell adenofibroma 10.2
37 cystadenofibroma 10.2
38 carcinoid syndrome 10.2
39 lymphomatous thyroiditis 10.2
40 colloid adenoma 10.1 NKX2-1 TG
41 fetal adenoma 10.1 NKX2-1 TG
42 adenofibroma 10.1 BRAF MUC16
43 ovarian cystic teratoma 10.1 NKX2-1 TG
44 papillary adenocarcinoma 10.0 MUC16 NKX2-1
45 primary peritoneal carcinoma 10.0 MUC16 RET
46 endemic goiter 9.9 TG TSHR
47 postsurgical hypothyroidism 9.9 TG TSHR
48 hypertelorism 9.9 BRAF RET
49 nontoxic goiter 9.9 TG TSHR
50 toxic diffuse goiter 9.9 TG TSHR

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

MGI Mouse Phenotypes related to Struma Ovarii:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 BRAF NKX2-1 RET TG TSHR
2 digestive/alimentary MP:0005381 9.62 BRAF NKX2-1 RET TG
3 limbs/digits/tail MP:0005371 9.46 BRAF RET TG TSHR
4 neoplasm MP:0002006 9.26 BRAF NKX2-1 RET TSHR
5 nervous system MP:0003631 9.02 BRAF NKX2-1 RET TG TSHR

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 Hormone Antagonists
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

42
Thyroid, Ovary, T Cells, Bone, Colon, Eye, Thymus

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 351)
# Title Authors Year
1
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. ( 30394923 )
2019
2
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. ( 31007958 )
2019
3
An unusual case of struma ovarii causing ovarian torsion during pregnancy. ( 30880533 )
2019
4
The role of immunohistochemical examination in diagnosis of papillary thyroid cancer in struma ovarii. ( 30924920 )
2019
5
Ovarian Combined Brenner Tumor, Mucinous Cystadenoma and Struma Ovarii: First Report of a Rare Combination. ( 30134344 )
2018
6
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
7
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2018
8
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
9
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
10
The Smallest Reported Malignant Struma Ovarii: A Case Report. ( 30483100 )
2018
11
Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: A case report. ( 30572559 )
2018
12
Struma ovarii - ultrasound features of a rare tumor mimicking ovarian cancer. ( 30167590 )
2018
13
Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of 131I scintigraphy and 18F-FDG PET: case report and review of the literature. ( 29391043 )
2018
14
A Rare Case: Struma Ovarii in a 14-Year-Old Girl. ( 28759301 )
2018
15
Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. ( 29455317 )
2018
16
The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature. ( 30061934 )
2018
17
Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. ( 30087949 )
2018
18
An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report. ( 30196119 )
2018
19
Struma Ovarii: A Report of Three Cases and Literature Review. ( 30692823 )
2018
20
Struma Ovarii With Hyperthyroidism. ( 28394842 )
2017
21
Hyperthyroidism due to struma ovarii: Diagnostic pitfalls and preventing thyroid storm. ( 30254866 )
2017
22
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
23
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
24
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
25
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
26
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
27
Papillary carcinoma in struma ovarii. ( 28251552 )
2017
28
Struma Ovarii with Pseudo-Meigs' Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma Case report and literature review. ( 28690899 )
2017
29
Erratum to: Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Non-Lactating Breast Simultaneously on Post-Ablation SPECT/CT for Papillary Thyroid Cancer. ( 28559950 )
2017
30
Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review. ( 29264493 )
2017
31
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2016
32
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
33
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
34
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
35
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
36
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
37
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
38
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
39
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
40
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
41
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. ( 27190936 )
2016
42
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. ( 27141138 )
2016
43
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. ( 27258816 )
2016
44
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. ( 27381498 )
2016
45
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation 131I SPECT/CT for Papillary Thyroid Cancer. ( 27994692 )
2016
46
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
47
Struma ovarii accompanied by mature cystic teratoma of the other ovary: A case report and literature review. ( 26137011 )
2015
48
Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii. ( 26185700 )
2015
49
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. ( 26530865 )
2015
50
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

Pathways related to Struma Ovarii according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.07 BRAF RET
2 10.79 BRAF TSHR
3 9.4 TG TSHR

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 BRAF NKX2-1
2 positive regulation of gene expression GO:0010628 9.13 BRAF NKX2-1 RET
3 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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