MCID: STR021
MIFTS: 39

Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Struma Ovarii

MalaCards integrated aliases for Struma Ovarii:

Name: Struma Ovarii 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 44 D013330
NCIt 50 C7468
SNOMED-CT 67 24327009
UMLS 70 C0038478

Summaries for Struma Ovarii

Disease Ontology : 12 An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue.

MalaCards based summary : Struma Ovarii is related to malignant struma ovarii and thyroid cancer, nonmedullary, 1. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Pathways in cancer. The drugs Iodine and Cadexomer iodine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and lung, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 31.7 TG RET NKX2-1 NCOA4 KRT19
2 thyroid cancer, nonmedullary, 1 31.5 NKX2-1 BRAF
3 mature teratoma 31.4 KRAS BRAF
4 cystic teratoma 31.2 NKX2-1 KRAS
5 graves disease 1 31.2 TSHR TG
6 benign teratoma 30.9 TG NKX2-1
7 benign struma ovarii 30.9 TSHR TG RET NKX2-1 NCOA4 KRT19
8 thyroiditis 30.8 TSHR TG RET
9 thyroid tumor 30.6 RET BRAF
10 thyroid cancer, nonmedullary, 2 30.5 TSHR TG BRAF
11 ovarian serous cystadenocarcinoma 30.4 MUC16 KRAS BRAF
12 ovarian germ cell teratoma 30.3 TG RET NKX2-1 NCOA4 KRT19
13 thyroid crisis 30.3 TSHR TG
14 thyroid carcinoma 30.3 TSHR TG RET NKX2-1 NCOA4 BRAF
15 hypothyroidism 30.2 TSHR TG RET NKX2-1 BRAF
16 exophthalmos 30.1 TSHR TG
17 adenoma 30.0 TSHR TG RET KRAS BRAF
18 adenocarcinoma 30.0 RET NKX2-1 KRAS BRAF
19 goiter 29.9 TSHR TG RET NKX2-1 KRT19
20 papillary adenocarcinoma 29.9 NKX2-1 MUC16 KRT19 KRAS
21 ovary adenocarcinoma 29.9 MUC16 KRAS BRAF
22 serous cystadenocarcinoma 29.9 MUC16 KRAS BRAF
23 papillary thyroid microcarcinoma 29.8 TSHR TG NKX2-1 BRAF
24 ovarian germ cell cancer 29.7 TG NKX2-1 NCOA4 KRT19
25 multinodular goiter 29.6 TSHR TG NKX2-1 KRT19
26 papillary carcinoma 29.5 TSHR TG RET NKX2-1 NCOA4 KRT19
27 endometrial cancer 29.4 RET NKX2-1 MUC16 KRAS BRAF
28 follicular adenoma 29.4 TSHR TG RET NKX2-1 KRT19 BRAF
29 nodular goiter 29.3 TSHR TG RET KRT19 BRAF
30 hashimoto thyroiditis 29.2 TSHR TG RET NCOA4 KRT19 BRAF
31 thyroid gland disease 29.0 TSHR TG RET NKX2-1 NCOA4
32 differentiated thyroid carcinoma 29.0 TSHR TG RET NKX2-1 NCOA4 KRAS
33 thyroid gland follicular carcinoma 28.6 TSHR TG RET NKX2-1 NCOA4 KRT19
34 thyroid gland cancer 28.0 TSHR TG RET NKX2-1 NCOA4 KRT19
35 teratoma 11.1
36 teratoma, ovarian 10.9
37 hyperthyroidism 10.9
38 rare tumor 10.7
39 pseudo-meigs syndrome 10.7
40 ovarian cyst 10.7
41 graves' disease 10.6
42 germ cells tumors 10.6
43 ovarian brenner tumor 10.6
44 cystadenoma 10.5
45 ovarian cancer 10.4
46 ovarian cystic teratoma 10.3
47 carotid body cancer 10.2 TG NKX2-1
48 multicentric papillary thyroid carcinoma 10.2 TG RET
49 ectopic thymus 10.2 TG NKX2-1
50 thyroid angiosarcoma 10.2 TG NKX2-1

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

GenomeRNAi Phenotypes related to Struma Ovarii according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.6 BRAF KRAS
2 Decreased viability GR00055-A-2 9.6 BRAF KRAS
3 Decreased viability GR00055-A-3 9.6 KRAS
4 Decreased viability GR00106-A-0 9.6 KRAS
5 Decreased viability GR00221-A-1 9.6 KRAS RET
6 Decreased viability GR00221-A-2 9.6 KRAS RET
7 Decreased viability GR00221-A-4 9.6 BRAF RET
8 Decreased viability GR00249-S 9.6 BRAF
9 Decreased viability GR00301-A 9.6 BRAF KRAS RET
10 Decreased viability GR00381-A-1 9.6 BRAF KRAS
11 Decreased viability GR00402-S-2 9.6 RET

MGI Mouse Phenotypes related to Struma Ovarii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 BRAF KRAS KRT19 NCOA4 NKX2-1 RET
2 endocrine/exocrine gland MP:0005379 9.95 BRAF KRAS KRT19 NKX2-1 RET TG
3 digestive/alimentary MP:0005381 9.91 BRAF KRAS KRT19 NKX2-1 RET TG
4 neoplasm MP:0002006 9.8 BRAF KRAS KRT19 NKX2-1 RET TSHR
5 nervous system MP:0003631 9.8 BRAF KRAS KRT19 NKX2-1 RET TG
6 limbs/digits/tail MP:0005371 9.77 BRAF KRAS RET TG TSHR
7 reproductive system MP:0005389 9.7 BRAF KRAS KRT19 NKX2-1 RET TG
8 respiratory system MP:0005388 9.35 BRAF KRAS KRT19 NKX2-1 RET
9 skeleton MP:0005390 9.1 BRAF KRAS KRT19 NKX2-1 TG TSHR

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2
Cadexomer iodine Experimental 94820-09-4
3 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone Completed NCT01441154
2 MOLecular Characterization and Treatment of THYroid Carcinoma on Struma Ovarii Not yet recruiting NCT04053114

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

40
Thyroid, Ovary, Lung, Pituitary, Thymus, Myeloid, Lymph Node

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 584)
# Title Authors PMID Year
1
Cystic struma ovarii presenting as pseudo-Meigs' syndrome with elevated CA125 levels. A case report and review of the literature. 61 54
18334015 2008
2
Cytologic differentiation of struma ovarii from other ovarian neoplasms. 61 54
18323278 2008
3
Struma ovarii with pseudo-Meigs' syndrome and elevated CA125 levels. 54 61
17365481 2007
4
Expression of thyroid transcription factor 1 (TTF-1) in extra thyroidal sites: papillary thyroid carcinoma of branchial cleft cysts and thyroglossal duct cysts and struma ovarii. 54 61
17285841 2006
5
Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. 61 54
16910883 2006
6
Struma ovarii showing clinical characteristics of ovarian malignancy. 54 61
16343201 2005
7
Pseudo-Meigs syndrome and elevated CA125 associated with struma ovarii. 54 61
15790478 2005
8
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. 61 54
16512597 2005
9
Coexisting Brenner tumor and struma ovarii in the right ovary: case report and review of the literature. 54 61
15482570 2004
10
Struma Ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. 61 54
15350384 2004
11
Expression of thyroid transcription factor-1 in strumal carcinoid and struma ovarii: an immunohistochemical study. 61 54
12167104 2002
12
Malignant struma ovarii: recurrence and response to treatment monitored by thyroglobulin levels. 61 54
9790800 1998
13
Malignant struma ovarii: surgical, histopathological and survival outcomes for thyroid-type carcinoma of struma ovarii with recommendations for standardising multi-modal management. A retrospective case series sharing the experience of a single institution over 10 years. 61
33512594 2021
14
Struma ovarii in bilateral ovarian teratoma-case report and literature review. 61
33732424 2021
15
An unusual case of struma ovarii. 61
33682680 2021
16
Methylation profiles of imprinted genes are distinct between mature ovarian teratoma, complete hydatidiform mole, and extragonadal mature teratoma. 61
32873866 2021
17
Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations. 61
32743766 2021
18
The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients. 61
33763376 2021
19
Metabolic Response by 18F-FDG PET/CT in Metastatic Malignant Struma Ovarii Treated With Targeted Therapies. 61
33181745 2021
20
Complete response of recurrent malignant struma ovarii followed by 131I therapy. 61
32515669 2021
21
Spreading of struma ovarii tumour via a lumbo-peritoneal shunt: first case report and short review of the literature. 61
31631700 2020
22
Correction to: Malignant struma ovarii: next-generation sequencing of six cases revealed Nras, Braf, and Jak3 mutations. 61
33025560 2020
23
Struma ovarii: two case reports of a rare teratoma of the ovary. 61
33343869 2020
24
Follicular carcinoma arising from struma ovarii. A case report. 61
33393527 2020
25
[Struma ovarii: A rare ovarian tumor to know]. 61
32470557 2020
26
Thyroid tissue outside the thyroid gland: Differential diagnosis and associated diagnostic challenges. 61
32871503 2020
27
Papillary thyroid carcinoma in Struma Ovarii. 61
32041443 2020
28
Papillary Thyroid Carcinoma in Struma Ovarii. 61
32391231 2020
29
Highly differentiated follicular carcinoma of ovary: Use of imprint cytology at intraoperative consultation. 61
31793246 2020
30
Pure T3 thyrotoxicosis from a Struma Ovarii characterised by a paradoxical rise in thyroxine on treatment. 61
32168467 2020
31
Malignant struma ovarii with a robust response to radioactive iodine. 61
32061155 2020
32
Multiple malignant transformations of an ovarian mature cystic teratoma. 61
32256692 2020
33
Ovarian tumors: a survey of selected advances of note during the life of this journal. 61
31654691 2020
34
Whole-Genome and Segmental Homozygosity Confirm Errors in Meiosis as Etiology of Struma Ovarii. 61
31865307 2020
35
Papillary Thyroid Cancer in a Struma Ovarii in a 17-Year-Old Nulliparous Patient: A case Report. 61
31952290 2020
36
FIGO Stage IV and Age Over 55 Years as Prognostic Predicators in Patients With Metastatic Malignant Struma Ovarii. 61
33117719 2020
37
Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature. 61
31679038 2019
38
Malignant Thyroid-type Papillary Neoplasm in Struma Ovarii: A Case Report. 61
32010534 2019
39
Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis. 61
31538107 2019
40
Ovarian Combined Brenner Tumor, Mucinous Cystadenoma and Struma Ovarii: First Report of a Rare Combination. 61
30134344 2019
41
When Graves' disease resists to surgery: A rare case of an association with follicular thyroid cancer in struma ovarii. 61
31708080 2019
42
An unusual case of struma ovarii causing ovarian torsion during pregnancy. 61
30880533 2019
43
Unusual Imaging Findings Associated with Germ Cell Tumors. 61
31125295 2019
44
Retrospective evaluation of pathological results among women with ovarian endometriomas versus teratomas. 61
31086669 2019
45
Struma ovarii complicating pregnancy. Case report and literature review. 61
31484009 2019
46
Imprint cytology of strumal carcinoid of the ovary: A case report with immunocytochemical analysis. 61
30485710 2019
47
Sudden, Unexpected Death Due to Pseudo-Meigs Syndrome: A Case Report and Review of the Literature. 61
30359338 2019
48
The role of immunohistochemical examination in diagnosis of papillary thyroid cancer in struma ovarii. 61
30924920 2019
49
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. 61
30394923 2019
50
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. 61
31007958 2019

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.43 RET KRAS BRAF
2 visual learning GO:0008542 9.32 KRAS BRAF
3 positive regulation of gene expression GO:0010628 9.26 RET NKX2-1 KRAS BRAF
4 epithelial tube branching involved in lung morphogenesis GO:0060441 9.16 NKX2-1 KRAS
5 thyroid gland development GO:0030878 8.8 TG NKX2-1 BRAF

Molecular functions related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 8.92 TSHR KRT19 KRAS BRAF

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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