MCID: STR021
MIFTS: 36

Struma Ovarii

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Struma Ovarii

MalaCards integrated aliases for Struma Ovarii:

Name: Struma Ovarii 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2640
MeSH 44 D013330
NCIt 50 C7468
SNOMED-CT 68 189851000 24327009
UMLS 73 C0038478

Summaries for Struma Ovarii

MalaCards based summary : Struma Ovarii is related to malignant struma ovarii and benign struma ovarii. An important gene associated with Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are VEGF Pathway (Tocris) and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related phenotypes are endocrine/exocrine gland and neoplasm

Wikipedia : 76 A struma ovarii (literally: goitre of the ovary) is a rare form of monodermal teratoma that contains... more...

Related Diseases for Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 malignant struma ovarii 33.1 NKX2-1 RET TG
2 benign struma ovarii 32.5 RET TG TSHR
3 thyroiditis 30.1 RET TG TSHR
4 ovarian germ cell teratoma 30.0 NKX2-1 RET TG
5 hyperthyroidism 29.9 TG TSHR
6 thyroid cancer, nonmedullary, 1 29.5 BRAF NKX2-1 RET TG
7 adenoma 29.1 BRAF RET TSHR
8 hashimoto thyroiditis 29.0 RET TG TSHR
9 goiter 29.0 NKX2-1 TG TSHR
10 hypothyroidism 28.2 NKX2-1 RET TG TSHR
11 papillary thyroid microcarcinoma 28.2 BRAF NKX2-1 TG TSHR
12 thyroid cancer 27.9 BRAF NKX2-1 RET TG TSHR
13 papillary carcinoma 27.7 BRAF NKX2-1 RET TG TSHR
14 differentiated thyroid carcinoma 27.1 BRAF NKX2-1 RET TG TSHR
15 thyroid cancer, nonmedullary, 2 27.1 BRAF NKX2-1 RET TG TSHR
16 lymphedema, hereditary, ii 10.6
17 pseudo-meigs syndrome 10.6
18 teratoma 10.5
19 graves' disease 10.5
20 peritonitis 10.4
21 cystadenoma 10.3
22 malignant teratoma 10.3 NKX2-1 TG
23 cervicitis 10.2
24 adenofibroma 10.2 BRAF MUC16
25 ovarian cystic teratoma 10.2 NKX2-1 TG
26 newborn respiratory distress syndrome 10.2 BRAF NKX2-1
27 ovarian cancer 10.1
28 dermoid cyst 10.1
29 cystic teratoma 10.1
30 endometriosis 10.1
31 adenocarcinoma 10.1
32 benign mesothelioma 10.0 MUC16 NKX2-1
33 papillary adenocarcinoma 10.0 MUC16 NKX2-1
34 ovarian serous cystadenocarcinoma 10.0 BRAF MUC16
35 thyroglossal duct cyst, familial 10.0
36 gonadoblastoma 10.0
37 ovarian cancer 1 10.0
38 mucinous ovarian cystadenoma 10.0
39 ovarian cystadenoma 10.0
40 cerebritis 10.0
41 sertoli cell tumor 10.0
42 pituitary adenoma 10.0
43 cystadenofibroma 10.0
44 carcinoid syndrome 10.0
45 neonatal hypothyroidism 9.9 TG TSHR
46 primary peritoneal carcinoma 9.9 MUC16 RET
47 hypertelorism 9.9 BRAF RET
48 endemic goiter 9.9 TG TSHR
49 graves disease 1 9.9 TG TSHR
50 nontoxic goiter 9.9 TG TSHR

Graphical network of the top 20 diseases related to Struma Ovarii:



Diseases related to Struma Ovarii

Symptoms & Phenotypes for Struma Ovarii

MGI Mouse Phenotypes related to Struma Ovarii:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.55 BRAF NKX2-1 RET TG TSHR
2 neoplasm MP:0002006 9.26 BRAF NKX2-1 RET TSHR
3 nervous system MP:0003631 9.02 BRAF NKX2-1 RET TG TSHR

Drugs & Therapeutics for Struma Ovarii

Drugs for Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Struma Ovarii

Cochrane evidence based reviews: struma ovarii

Genetic Tests for Struma Ovarii

Anatomical Context for Struma Ovarii

MalaCards organs/tissues related to Struma Ovarii:

41
Thyroid, Ovary, Liver, Bone, Testes, Pituitary, Thymus

Publications for Struma Ovarii

Articles related to Struma Ovarii:

(show top 50) (show all 331)
# Title Authors Year
1
Precise preoperative diagnosis of struma ovarii with pseudo-Meigs' syndrome mimicking ovarian cancer with the combination of<sup>131</sup>I scintigraphy and<sup>18</sup>F-FDG PET: case report and review of the literature. ( 29391043 )
2018
2
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
3
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. ( 29318892 )
2018
4
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
5
Genetic zygosity of mature ovarian teratomas, struma ovarii, and ovarian carcinoids. ( 29455317 )
2018
6
Concurrent Intrathyroidal Thyroid Cancer and Thyroid Cancer in Struma Ovarii: A Case Report and Literature Review. ( 29264493 )
2017
7
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
8
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
9
A Rare Case: Struma Ovarii in a 14-Year-Old Girl. ( 28759301 )
2017
10
Papillary carcinoma in struma ovarii. ( 28251552 )
2017
11
Struma Ovarii with Pseudo-Meigs' Syndrome and Raised Cancer Antigen-125 Levels Masquerading as an Ovarian Carcinoma Case report and literature review. ( 28690899 )
2017
12
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
13
A Case of Unilateral Endometriosis Coexisting with Struma Ovarii in Bilateral Ovarian Teratoma. ( 29223697 )
2017
14
Struma Ovarii With Hyperthyroidism. ( 28394842 )
2017
15
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
16
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
17
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
18
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
19
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
20
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
21
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
22
Incidental Findings of Intense Radioiodine Uptake in Struma Ovarii and Bilateral Nonlactating Breasts Simultaneously on Postablation (131)I SPECT/CT for Papillary Thyroid Cancer. ( 27994692 )
2016
23
Follicular Variant of Papillary Carcinoma Arising in Struma Ovarii. ( 27190936 )
2016
24
Level of HE4 is Correlated with Diagnosis of Struma Ovarii: A Case Report. ( 27381498 )
2016
25
Struma Ovarii With Malignant Transformation and Germline KIT Mutation: A Case Report With Review of the Literature. ( 27258816 )
2016
26
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
27
Incidental diagnosis of struma ovarii through radioiodine whole-body scanning: incremental role of SPECT/CT. ( 27141138 )
2016
28
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
29
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
30
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
31
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015
32
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior. ( 26072948 )
2015
33
Pathology of Struma Ovarii: A Report of 96 Cases. ( 26374222 )
2015
34
Coexistence of benign struma ovarii, pseudo-Meigs' syndrome and elevated serum CA 125: Case report and review of the literature. ( 25789033 )
2015
35
Struma ovarii: management and follow-up of a rare ovarian tumour. ( 25640097 )
2015
36
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
37
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
38
Struma ovarii complicating pregnancy: a case report. ( 26411234 )
2015
39
Spinal metastasis from struma ovarii: case report and review of the literature. ( 25901242 )
2015
40
Novel BRAF and KRAS Mutations in Papillary Thyroid Carcinoma Arising in Struma Ovarii. ( 26362194 )
2015
41
Sonographic and Pathologic Features of Struma Ovarii. ( 26149143 )
2015
42
Follicular proliferative lesion arising in struma ovarii. ( 26018519 )
2015
43
Struma Ovarii in Pregnancy: An Uncommon Cause of Hyperthyroidism. ( 26018691 )
2015
44
Coexistence of Graves' disease and unilateral functioning Struma ovarii: a case report. ( 26530865 )
2015
45
Struma ovarii accompanied by mature cystic teratoma of the other ovary: A case report and literature review. ( 26137011 )
2015
46
Usefulness of (131)I-SPECT/CT and (18)F-FDG PET/CT in Evaluating Successful (131)I and Retinoic Acid Combined Therapy in a Patient with Metastatic Struma Ovarii. ( 25774238 )
2015
47
Poorly Differentiated Thyroid Carcinoma Arising in Struma Ovarii. ( 26185700 )
2015
48
METASTATIC RADIOIODINE AVID STRUMA OVARII ASSOCIATED WITH PSEUDO-MEIGS' SYNDROME. ( 26721055 )
2015
49
Late Manifestation of Peritoneal strumosis and widespread functioning lesions in the setting of Struma Ovarii simulating &amp;quot;Highly Differentiated Follicular Carcinoma&amp;quot; (HDFCO). ( 25537757 )
2014
50
Diagnosis of struma ovarii in a patient with papillary thyroid carcinoma--verification via 124I-PET/US fusion. ( 24458572 )
2014

Variations for Struma Ovarii

Expression for Struma Ovarii

Search GEO for disease gene expression data for Struma Ovarii.

Pathways for Struma Ovarii

Pathways related to Struma Ovarii according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.07 BRAF RET
2 10.79 BRAF TSHR
3 9.4 TG TSHR

GO Terms for Struma Ovarii

Biological processes related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of signal transduction GO:0009968 9.16 BRAF RET
2 positive regulation of gene expression GO:0010628 9.13 BRAF NKX2-1 RET
3 thyroid gland development GO:0030878 8.8 BRAF NKX2-1 TG

Molecular functions related to Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase kinase activity GO:0004709 8.96 BRAF RET
2 mitogen-activated protein kinase kinase binding GO:0031434 8.62 BRAF RET

Sources for Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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