SCD
MCID: SBC039
MIFTS: 22

Subacute Cerebellar Degeneration (SCD)

Categories: Metabolic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Subacute Cerebellar Degeneration

MalaCards integrated aliases for Subacute Cerebellar Degeneration:

Name: Subacute Cerebellar Degeneration 53
Alcoholic Cerebellar Degeneration 53 72
Cerebellar Degeneration, Subacute 53 72
Nutritional Cerebellar Degeneration 53
Scd 53

Classifications:



External Ids:

UMLS 72 C0338442 C2930879

Summaries for Subacute Cerebellar Degeneration

NIH Rare Diseases : 53 Subacute cerebellar degeneration is the breakdown of the area of the brain that controls muscle coordination and balance (the cerebellum). Less commonly, the area connecting the spinal cord to the brain is involved. Subacute cerebellar degeneration may occur in association with a cancer (paraneoplastic cerebellar degeneration) or lack of thiamine (alcoholic or nutritional cerebellar degeneration). Signs and symptoms may include ataxia, speech and swallowing problems, dementia, vision problems, and vertigo.

MalaCards based summary : Subacute Cerebellar Degeneration, also known as alcoholic cerebellar degeneration, is related to sickle cell disease and schnyder corneal dystrophy, and has symptoms including cerebellar ataxia Affiliated tissues include brain, spinal cord and cerebellum.

Related Diseases for Subacute Cerebellar Degeneration

Diseases in the Cerebellar Degeneration family:

Primary Cerebellar Degeneration Subacute Cerebellar Degeneration

Diseases related to Subacute Cerebellar Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 sickle cell disease 12.4
2 schnyder corneal dystrophy 12.1
3 ehlers-danlos syndrome, spondylodysplastic type, 3 11.8
4 sickle cell anemia 11.8
5 cardiac conduction defect 11.6
6 hemoglobinopathy 11.6
7 qt interval, variation in 11.5
8 abdominal obesity-metabolic syndrome 1 11.4
9 diabetes mellitus, noninsulin-dependent 11.3
10 fanconi anemia, complementation group d2 11.3
11 body mass index quantitative trait locus 11 11.3
12 lipodystrophy, congenital generalized, type 3 11.3
13 lipodystrophy, congenital generalized, type 4 11.3
14 reye syndrome 11.3
15 carnitine deficiency, systemic primary 11.3
16 spondylocostal dysostosis 3, autosomal recessive 11.2
17 fanconi anemia, complementation group a 11.2
18 superior semicircular canal dehiscence 11.2
19 semicircular canal dehiscence syndrome 11.2
20 obsolete: secondary ciliary dyskinesia 11.2
21 cerebellar degeneration 10.7
22 ataxia and polyneuropathy, adult-onset 10.4
23 lambert-eaton myasthenic syndrome 10.4
24 hypertrophic cardiomyopathy 10.4
25 syncope 10.4
26 atrial standstill 1 10.3
27 acute chest syndrome 10.3
28 renal oncocytoma 10.3
29 hemosiderosis 10.3
30 congestive heart failure 10.3
31 rare hereditary hemochromatosis 10.3
32 lambert syndrome 10.3
33 cardiac arrest 10.2
34 thalassemia 10.2
35 heart disease 10.2
36 alcohol dependence 10.2
37 paraneoplastic cerebellar degeneration 10.2
38 coronary heart disease 1 10.2
39 infertility 10.2
40 spinocerebellar degeneration 10.2
41 aceruloplasminemia 10.2
42 small cell carcinoma 10.2
43 paraneoplastic syndromes 10.2
44 colorectal cancer 10.1
45 beta-thalassemia 10.1
46 male infertility 10.1
47 dilated cardiomyopathy 10.1
48 spinal stenosis 10.1
49 fatty liver disease 10.1
50 avascular necrosis 10.1

Graphical network of the top 20 diseases related to Subacute Cerebellar Degeneration:



Diseases related to Subacute Cerebellar Degeneration

Symptoms & Phenotypes for Subacute Cerebellar Degeneration

UMLS symptoms related to Subacute Cerebellar Degeneration:


cerebellar ataxia

Drugs & Therapeutics for Subacute Cerebellar Degeneration

Search Clinical Trials , NIH Clinical Center for Subacute Cerebellar Degeneration

Genetic Tests for Subacute Cerebellar Degeneration

Anatomical Context for Subacute Cerebellar Degeneration

MalaCards organs/tissues related to Subacute Cerebellar Degeneration:

41
Brain, Spinal Cord, Cerebellum, Lung, Breast, Colon, Ovary

Publications for Subacute Cerebellar Degeneration

Articles related to Subacute Cerebellar Degeneration:

(show top 50) (show all 82)
# Title Authors PMID Year
1
Neurologic presentations of nutritional deficiencies. 6
19932379 2010
2
[A Case of Rectal Colon Cancer with Paraneoplastic Cerebellar Degeneration]. 38
30382061 2018
3
Prognostic Factors in Anti-Neuronal Antibody Positive Patients. 38
30057463 2018
4
Thymic Carcinoma Associated with Cerebellar Degeneration. 38
30756016 2018
5
Subacute Cerebellar Degeneration as the First Manifestation of Sjögren's Syndrome. 38
30713975 2017
6
Subacute Cerebellar Degeneration due to a Paraneoplastic Phenomenon Associated with Metastatic Merkel Cell Carcinoma: A Case Report. 38
28878663 2017
7
Screening for anti-titin antibodies in patients with various paraneoplastic neurological syndromes. 38
27235344 2016
8
"Non-classical" paraneoplastic neurological syndromes associated with well-characterized antineuronal antibodies as compared to "classical" syndromes - More frequent than expected. 38
25824848 2015
9
Cerebellar degeneration associated with mGluR1 autoantibodies as a paraneoplastic manifestation of prostate adenocarcinoma. 38
23958353 2013
10
Unusual paraneoplastic syndromes of breast carcinoma: a combination of cerebellar degeneration and Lambert-Eaton Myasthenic Syndrome. 38
19005633 2011
11
A myxoid chondrosarcoma associated with an anti-Hu-positive paraneoplastic encephalomyelitis. 38
20443130 2011
12
Paraneoplastic syndromes in patients with primary oral cancers: a systematic review. 38
19833419 2010
13
[Case of anti P/Q type VGCC antibody positive small lung cell carcinoma that occured with subacute cerebellar degeneration, Lambert-Eaton myasthenic syndrome, and brainstem encephalitis]. 38
19110759 2008
14
[Paraneoplastic neurological syndromes]. 38
17399944 2007
15
Paraneoplastic syndrome: subacute cerebellar degeneration in Hodgkin's disease. 38
17454645 2007
16
[Multiple paraneoplastic syndromes occurring in the same patient: clinical, imaging and neuro-pathological documentation]. 38
17583609 2006
17
Subacute cerebellar degeneration as paraneoplastic syndrome: initial symptom of breast cancer with HER2 overexpression. 38
16764747 2006
18
Subacute cerebellar degeneration associated with calcitonin producing tumor. 38
16132494 2006
19
Paraneoplastic stiff-person syndrome: passive transfer to rats by means of IgG antibodies to amphiphysin. 38
15836889 2005
20
Paraneoplastic neurological disorders in breast cancer. 38
14659327 2003
21
Pathogenesis and treatment of paraneoplastic neurologic syndrome. 38
19810923 2002
22
Paraneoplastic syndromes associated with lung cancer: a unique case of concomitant subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome. 38
11726443 2001
23
Paraneoplastic cerebellar degeneration heralding fallopian tube adenocarcinoma. 38
11328418 2001
24
[A Lambert-Faton myasthenic syndrome and subacute cerebellar degeneration with a favorable clinical course after resection of small-cell lung cancer]. 38
11296368 2000
25
[Paraneoplastic subacute cerebellar degeneration: case report]. 38
10973125 2000
26
[Subacute cerebellar degeneration and pleural mesothelioma. Report of a case]. 38
11512388 2000
27
Association of anti-Yo (type I) antibody with paraneoplastic cerebellar degeneration in the setting of transitional cell carcinoma of the bladder: detection of Yo antigen in tumor tissue and fall in antibody titers following tumor removal. 38
10360776 1999
28
[The Eaton-Lambert myasthenic syndrome and subacute cerebellar degeneration of a nonparaneoplastic origin: a review of a case 4 years later]. 38
10065441 1999
29
Paraneoplastic cerebellar degeneration. Case report and literature review. 38
9183238 1997
30
Normalization of the tumor marker CA-125 after oophorectomy in a patient with paraneoplastic cerebellar degeneration without detectable cancer. 38
9103409 1997
31
[A nationwide survey on paraneoplastic neurological syndromes. Project group on paraneoplastic neurological syndromes, Neuroimmunological Disease Research Committee, the Ministry of Health and Welfare, Japan]. 38
9164138 1997
32
Subacute cerebellar degeneration as a remote effect of breast cancer. 38
9833407 1997
33
[Paraneoplastic neurological syndrome: diagnosis and therapy]. 38
9128413 1996
34
Co-existence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration in a patient with rheumatoid arthritis. 38
24283638 1995
35
[The association of the Eaton-Lambert myasthenic syndrome and subacute cerebellar degeneration of nonparaneoplastic origin]. 38
7700091 1995
36
[Neurologic paraneoplastic syndromes]. 38
7771203 1995
37
Subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome associated with antibodies to voltage-gated calcium channels: differential effect of immunosuppressive therapy on central and peripheral defects. 38
8089692 1994
38
[Establishment and characterization of a human small cell lung carcinoma cell line (MT-428) derived from the patient who showed neurological paraneoplastic syndrome]. 38
8025019 1994
39
Paraneoplastic subacute cerebellar degeneration: functional improvement and the role of rehabilitation. 38
8129592 1994
40
[Report of a case of small cell lung cancer associated with Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration--with a review of the Japanese literature]. 38
8192944 1994
41
Paraneoplastic syndromes: a challenge for neuroscience nursing. 38
8228394 1993
42
Cerebrospinal fluid 28-kDa calbindin-D as a possible marker for Purkinje cell damage. 38
8229048 1993
43
Ovarian carcinoma causing cerebellar degeneration. 38
1294414 1992
44
Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma. 38
1335101 1992
45
Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome. 38
1407577 1992
46
[Cerebrospinal fluid levels of 28 kDa calcium-binding protein in patients with neurological diseases]. 38
1395324 1992
47
Pursuing an occult carcinoma in a patient with subacute cerebellar degeneration and anticerebellar antibodies. Need for vigorous follow-up. 38
1536083 1992
48
Paraneoplastic anti-Purkinje and type I anti-neuronal nuclear autoantibodies bind selectively to central, peripheral, and autonomic nervous system cells. 38
1921331 1991
49
Coexistence of Lambert-Eaton myasthenic syndrome and subacute cerebellar degeneration: differential effects of treatment. 38
1922820 1991
50
[Paraneoplastic neurologic syndromes]. 38
1829223 1991

Variations for Subacute Cerebellar Degeneration

Expression for Subacute Cerebellar Degeneration

Search GEO for disease gene expression data for Subacute Cerebellar Degeneration.

Pathways for Subacute Cerebellar Degeneration

GO Terms for Subacute Cerebellar Degeneration

Sources for Subacute Cerebellar Degeneration

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