MCID: SBC035
MIFTS: 36

Subacute Cutaneous Lupus Erythematosus

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 59
Lupus Erythematosus, Subacute Cutaneous 73
Lupus Erythematosus Cutaneous Subacute 55

Characteristics:

Orphanet epidemiological data:

59
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA163525
ICD10 via Orphanet 34 L93.1
UMLS via Orphanet 74 C0024140
ICD10 33 L93.1
UMLS 73 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and systemic lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21). The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver.

Wikipedia : 76 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Subacute Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 31.2 CD70 EEA1 TNF TRIM21
2 systemic lupus erythematosus 30.0 ACE CD70 TNF TRIM21
3 connective tissue disease 29.6 ACE TNF
4 neonatal lupus erythematosus 11.8
5 lupus erythematosus 11.2
6 porphyria cutanea tarda 10.3
7 rheumatoid arthritis 10.3
8 arthritis 10.3
9 porphyria 10.3
10 vasculitis 10.3
11 psoriasis 10.3
12 hepatitis 10.2
13 discoid lupus erythematosus 10.2
14 annular erythema 10.1
15 myositis 10.1
16 complement component 2 deficiency 10.1
17 erythema multiforme 10.1
18 tinea corporis 10.1
19 hepatitis c 10.1
20 adenocarcinoma 10.1
21 neuropathy 10.1
22 lichen planus 10.1
23 uveoparotid fever 10.1 ACE TNF
24 skin sarcoidosis 10.1 ACE TNF
25 granulomatous dermatitis 10.1 ACE TNF
26 posterior urethral valves 10.1 ACE TNF
27 ischemic heart disease 10.1 ACE TNF
28 melkersson-rosenthal syndrome 10.1 ACE TNF
29 hypersensitivity reaction type iv disease 10.0 ACE TNF
30 extrinsic cardiomyopathy 10.0 ACE TNF
31 rheumatic heart disease 10.0 ACE TNF
32 pyelonephritis 10.0 ACE TNF
33 limb ischemia 10.0 ACE TNF
34 silicosis 10.0 ACE TNF
35 carotid stenosis 10.0 ACE TNF
36 adult respiratory distress syndrome 10.0 ACE TNF
37 pulmonary sarcoidosis 10.0 ACE TNF
38 pulmonary edema 10.0 ACE TNF
39 sleep apnea 10.0 ACE TNF
40 diffuse infiltrative lymphocytosis syndrome 10.0 TNF TRIM21
41 end stage renal failure 10.0 ACE TNF
42 sialadenitis 10.0 TNF TRIM21
43 cogan syndrome 10.0 TNF TRIM21
44 lacrimal apparatus disease 10.0 TNF TRIM21
45 vascular dementia 10.0 ACE TNF
46 arteries, anomalies of 10.0 ACE TNF
47 exanthem 10.0 TNF TRIM21
48 glucose metabolism disease 10.0 ACE TNF
49 heart conduction disease 10.0 ACE TRIM21
50 membranous nephropathy 10.0 ACE TNF

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 449171 444795
2
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
3 Dermatologic Agents Phase 2,Not Applicable
4 Keratolytic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 Study to Evaluate BIIB059 in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) Recruiting NCT02847598 Phase 2 BIIB059;Placebo
4 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Terminated NCT01407679 Phase 2 Alitretinoin
5 Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
6 Pilot Tape Harvesting Study Completed NCT02125695
7 A Non-drug Study Profiling Cutaneous Lupus Completed NCT01923415
8 A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344
9 The Human Microbiome in Immune-Mediated Diseases Recruiting NCT02394964
10 Cutaneous Lupus Erythematosus and Elidel Withdrawn NCT00222183 Not Applicable Elidel (pimecrolimus)

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

41
Skin, Lung, Liver, Prostate, Heart, Eye, Spinal Cord

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 322)
# Title Authors Year
1
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger? ( 29327459 )
2018
2
Subacute Cutaneous Lupus Erythematosus Induced by Palbociclib. ( 29307217 )
2018
3
Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol. ( 29782299 )
2018
4
Subacute cutaneous lupus erythematosus presenting in twins. ( 29436018 )
2018
5
The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. ( 29631513 )
2018
6
Occupational subacute cutaneous lupus erythematosus caused by outdoor work. ( 29603599 )
2018
7
Rituximab in the treatment of extensive and refractory subacute cutaneous lupus erythematosus. ( 29924233 )
2018
8
Successful treatment of severe subacute cutaneous lupus erythematosus with rituximab in an adolescent. ( 29570834 )
2018
9
Isoniazid-induced subacute cutaneous lupus erythematosus in an HIV-positive woman: a rare side effect to be aware of with the current expansion of isoniazid preventive therapy. ( 30061978 )
2018
10
Subacute cutaneous lupus erythematosus and systemic lupus erythematosus associated with abatacept. ( 30167444 )
2018
11
Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death (PD)-1 therapy. ( 30244487 )
2018
12
Subacute cutaneous lupus erythematosus triggered by an antiviral treatment combination for hepatitis C virus infection. ( 30394571 )
2018
13
Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review. ( 30489484 )
2018
14
An update in drug-induced subacute cutaneous lupus erythematosus. ( 28329511 )
2017
15
Subacute cutaneous lupus erythematosus - paraneoplastic to gastric adenocarcinoma? ( 28421344 )
2017
16
Subacute cutaneous lupus erythematosus induced by masitinib. ( 28940367 )
2017
17
Subacute Cutaneous Lupus Erythematosus: Clinical Characteristics, Disease Associations, Treatments, and Outcomes in a Series of 90A Patients at Mayo Clinic, 1996-2011. ( 28185656 )
2017
18
Rowell's Syndrome or subacute cutaneous lupus erythematosus? ( 27978611 )
2017
19
Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. ( 28331627 )
2017
20
Subacute cutaneous lupus erythematosus induced by nivolumab. ( 28726325 )
2017
21
Lansoprazole-Induced Subacute Cutaneous Lupus Erythematosus. ( 30375575 )
2017
22
Proton Pump Inhibitor-Associated Subacute Cutaneous Lupus Erythematosus in a Patient With Granulomatosis With Polyangiitis. ( 27870768 )
2016
23
Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. ( 27888319 )
2016
24
Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). ( 26897388 )
2016
25
Subacute cutaneous lupus erythematosus. ( 27286780 )
2016
26
First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer. ( 27836354 )
2016
27
Lenalidomide for refractory chronic and subacute cutaneous lupus erythematosus: 16 patients. ( 27185425 )
2016
28
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report. ( 26928175 )
2016
29
Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors. ( 27398293 )
2016
30
Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with Leflunomide Therapy. ( 27891379 )
2016
31
Anastrozole-induced subacute cutaneous lupus erythematosus. ( 27622265 )
2016
32
Dermoscopy of subacute cutaneous lupus erythematosus. ( 27260752 )
2016
33
Voriconazole-Induced Subacute Cutaneous Lupus Erythematosus in an Adult With Aspergillosis. ( 28031137 )
2016
34
Docetaxel-induced-like subacute cutaneous lupus erythematosus. ( 26350359 )
2015
35
Subacute cutaneous lupus erythematosus induced by lansoprazole. ( 25855412 )
2015
36
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? ( 25876148 )
2015
37
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane. ( 26444320 )
2015
38
Imiquimod-induced subacute cutaneous lupus erythematosus-like changes. ( 26125212 )
2015
39
Subacute cutaneous lupus erythematosus induced by capecitabine: 5-FU was innocent. ( 26551520 )
2015
40
Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus. ( 26235783 )
2015
41
Drug-Induced Subacute Cutaneous Lupus Erythematosus in a Patient Receiving Therapy for Chronic Hepatitis C. ( 26539906 )
2015
42
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
43
Subacute cutaneous lupus erythematosus associated with pemetrexed plus Carboplatin chemotherapy. ( 25417687 )
2014
44
Pediatric subacute cutaneous lupus erythematosus: report of three cases. ( 25209420 )
2014
45
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). ( 25244994 )
2014
46
Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. ( 25369825 )
2014
47
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. ( 24520513 )
2014
48
Paraneoplastic subacute cutaneous lupus erythematosus associated with cholangiocarcinoma. ( 25367767 )
2014
49
Proton pump inhibitors and subacute cutaneous lupus erythematosus: an under-recognized phenomenon? ( 24547716 )
2014
50
Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib. ( 24909204 )
2014

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 EEA1 TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.16 TNF TRIM21
2 tumor necrosis factor-mediated signaling pathway GO:0033209 8.96 CD70 TNF
3 extrinsic apoptotic signaling pathway GO:0097191 8.62 CD70 TNF

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.33 ACE EEA1 TRIM21
2 protease binding GO:0002020 8.96 CD70 TNF
3 tumor necrosis factor receptor binding GO:0005164 8.62 CD70 TNF

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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