MCID: SBC035
MIFTS: 34

Subacute Cutaneous Lupus Erythematosus

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 58 32
Lupus Erythematosus, Subacute Cutaneous 70
Lupus Erythematosus Cutaneous Subacute 54

Characteristics:

Orphanet epidemiological data:

58
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L93.1
ICD10 via Orphanet 33 L93.1
UMLS via Orphanet 71 C0024140
Orphanet 58 ORPHA163525
UMLS 70 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and exanthem. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drug Alitretinoin has been mentioned in the context of this disorder. Affiliated tissues include t cells, thyroid and prostate.

Wikipedia : 73 Subacute cutaneous lupus erythematosus is a clinically distinct subset of cases of lupus erythematosus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Rare Cutaneous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 30.9 TRIM21 TNF IRF5 C1QA
2 exanthem 30.7 TRIM21 TNF
3 myositis 30.4 TRIM21 TNF
4 lupus erythematosus 30.3 TRIM21 TNF IRF5 C1QA
5 keratoconjunctivitis sicca 30.0 TRIM21 TNF
6 autoimmune disease 30.0 TRIM21 TNF IRF5
7 keratoconjunctivitis 29.8 TRIM21 TNF
8 systemic lupus erythematosus 29.6 TRIM21 TNF IRF5 C1QA
9 systemic scleroderma 29.3 TRIM21 TNF IRF5
10 neonatal lupus erythematosus 11.4
11 skin disease 10.6
12 discoid lupus erythematosus 10.6
13 erythema multiforme 10.5
14 connective tissue disease 10.5
15 vasculitis 10.5
16 enthesopathy 10.5
17 rare cutaneous lupus erythematosus 10.4
18 porphyria cutanea tarda 10.4
19 drug-induced lupus erythematosus 10.4
20 dermatomyositis 10.4
21 porphyria 10.4
22 pustulosis of palm and sole 10.4
23 psoriasis 10.4
24 lichen planus 10.4
25 annular erythema 10.4
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
27 alopecia 10.4
28 stevens-johnson syndrome/toxic epidermal necrolysis 10.4
29 raynaud phenomenon 10.4
30 dowling-degos disease 1 10.3
31 rheumatoid arthritis 10.3
32 vitiligo-associated multiple autoimmune disease susceptibility 6 10.3
33 complement component 2 deficiency 10.3
34 vitiligo-associated multiple autoimmune disease susceptibility 1 10.3
35 chilblain lupus 1 10.3
36 neutropenia 10.3
37 thrombocytopenia 10.3
38 purpura 10.3
39 complement deficiency 10.3
40 dermatophytosis 10.3
41 aspergillosis 10.2
42 invasive aspergillosis 10.2
43 anogenital venereal wart 10.2
44 tinea corporis 10.2
45 panniculitis 10.2
46 lymphadenitis 10.2
47 keratosis 10.2
48 hepatitis c 10.2
49 melanoma 10.2
50 autoimmune hepatitis 10.2

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Double-blind, Placebo-controlled, Proof-of-concept Study to Evaluate the Efficacy and Tolerability of KRP203 in Patients With Active Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 A Phase 2, Pilot, Multicenter, Sequential, Ascending Dose Study to Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus: A Multicentre, Open-Label, Prospective Pilot Study Terminated NCT01407679 Phase 2 Alitretinoin
4 A Randomized, Double-blind, Placebo-controlled, Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
5 Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE) Withdrawn NCT00222183 Elidel (pimecrolimus)

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

40
T Cells, Thyroid, Prostate, Colon, Endothelial

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 635)
# Title Authors PMID Year
1
Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. 54 61
12485445 2002
2
[Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by paraneoplastic subacute cutaneous lupus erythematosus]. 54 61
10584550 1999
3
Disparate locations of the 52- and 60-kDa Ro/SS-A antigens in cultured human keratinocytes. 61 54
8823371 1996
4
Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. 54 61
8676889 1996
5
Subacute cutaneous lupus erythematosus triggered after measles vaccination. 61
33573457 2021
6
Drug-induced subacute cutaneous lupus erythematosus associated with abatacept. 61
33349110 2021
7
Late onset of subacute cutaneous lupus erythematosus following pembrolizumab therapy. 61
33486439 2021
8
Dermoscopic Appearance of an Annular Subacute Cutaneous Lupus Erythematosus. 61
33747626 2021
9
Onset of subacute cutaneous lupus erythematosus after the initiation of immune checkpoint inhibitor therapy of cancer. 61
33407044 2021
10
NKG2D and its ligands as cytotoxic factors in cutaneous lupus erythematosus. 61
33687107 2021
11
[Paraneoplastic subacute cutaneous lupus erythematosus]. 61
33236165 2021
12
De novo subacute cutaneous lupus erythematosus-like eruptions in the setting of programmed death-1 or programmed death ligand-1 inhibitor therapy: clinicopathological correlation. 61
32939795 2021
13
Cutaneous toxicities occurring during palbociclib (CDK4/6 inhibitor) and endocrine therapy in patients with advanced breast cancer: a single-centre experience. 61
33683521 2021
14
Tofacitinib-induced subacute cutaneous lupus erythematosus in a patient with rheumatoid arthritis. 61
33492185 2021
15
Subacute cutaneous lupus erythematosus induced by PD-1 Inhibitor therapy: two case reports and literature review. 61
33484581 2021
16
Prevalence of antimitochondrial antibodies in subacute cutaneous lupus erythematosus. 61
33017043 2021
17
Brodalumab-induced subacute cutaneous lupus erythematosus. 61
33511692 2021
18
Systematic Review: Monoclonal Antibody-Induced Subacute Cutaneous Lupus Erythematosus. 61
32960413 2020
19
Vitiligo-like depigmentation subsequent to subacute cutaneous lupus erythematosus and hydroxychloroquine treatment. 61
32783375 2020
20
Alendronate induced subacute cutaneous lupus erythematosus successfully treated with intravenous immunoglobulin. 61
33125828 2020
21
A case of recombinant human follitropin alfa-induced subacute cutaneous lupus erythematosus presenting with erythema multiforme-like lesion. 61
32847460 2020
22
Multiple drugs as inducing or exacerbating agents in subacute cutaneous lupus erythematosus. 61
33128457 2020
23
Subacute Cutaneous Lupus Erythematosus in a Male Patient on Multiple Antiepileptics Unmasked by Melatonin. 61
31136412 2020
24
Subacute cutaneous lupus erythematosus in a patient with Sjögren's syndrome taking terbinafine for onychomycosis. 61
33420774 2020
25
Omeprazole-Induced Subacute Cutaneous Lupus Erythematosus. 61
32639541 2020
26
Association Between Drug Use and Subsequent Diagnosis of Lupus Erythematosus. 61
32876672 2020
27
Higher specificity of the new EULAR/ACR 2019 criteria for diagnosing systemic lupus erythematosus in patients with biopsy-proven cutaneous lupus. 61
32940207 2020
28
Subacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review. 61
32119141 2020
29
Three cases of subacute cutaneous lupus erythematosus associated with malignancy: a late paraneoplastic phenomenon. 61
31944366 2020
30
Childhood subacute cutaneous lupus erythematosus associated with transaminitis. 61
31850540 2020
31
Terbinafine-induced lichenoid drug eruption: case report and review of terbinafine-associated cutaneous adverse events. 61
32898398 2020
32
Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. 61
32173880 2020
33
Secukinumab-induced subacute cutaneous lupus erythematosus. 61
32291870 2020
34
Vesiculobullous Subacute Cutaneous Lupus Erythematosus: A Rare Presentation. 61
32695716 2020
35
Successful ustekinumab treatment in a patient with psoriasis and subacute cutaneous lupus erythematosus. 61
31957866 2020
36
Discoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review. 61
32467803 2020
37
Cutaneous effects of antihypertensive drugs. 61
31195782 2020
38
Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events. 61
31965545 2020
39
Metastatic prostate cancer presenting as subacute cutaneous lupus erythematosus. 61
31407804 2020
40
Proton Pump Inhibitor-Induced Subacute Cutaneous Lupus Erythematosus. 61
31427196 2020
41
Clinicopathologic comparison of Rowell syndrome, erythema multiforme, and subacute cutaneous lupus erythematosus. 61
31629618 2019
42
Subacute cutaneous lupus erythematosus leukoderma treated with melanocyte-keratinocyte transplantation procedure. 61
30932304 2019
43
Drug-induced anti-Ro positive subacute cutaneous lupus in a man treated with olmesartan. 61
32045161 2019
44
Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature. 61
32045142 2019
45
Subacute cutaneous lupus erythematosus with a possible paraneoplastic association with melanoma. 61
31780613 2019
46
Widespread subacute cutaneous lupus erythematosus in a patient receiving checkpoint inhibitor immunotherapy with ipilimumab and nivolumab. 61
31735010 2019
47
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma. 61
31611227 2019
48
Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy. 61
30244487 2019
49
Capecitabine-induced Subacute Cutaneous Lupus Erythematosus. 61
31777367 2019
50
UV radiation exposure in welders: impact on the skin and eyes. 61
31675405 2019

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 TRIM21 TNF IRF5 EEA1 C1QA
2
Show member pathways
12.43 TNF IRF5 C1QA
3 11.41 TNF EEA1
4 10.84 TNF C1QA

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 TNF EEA1

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.43 TRIM21 IRF5 C1QA
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.4 TRIM21 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.37 TRIM21 TNF
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.32 TRIM21 TNF
5 interferon-gamma-mediated signaling pathway GO:0060333 9.16 TRIM21 IRF5
6 microglial cell activation GO:0001774 8.96 TNF C1QA
7 astrocyte activation GO:0048143 8.62 TNF C1QA

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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