MCID: SBC035
MIFTS: 37

Subacute Cutaneous Lupus Erythematosus

Categories: Skin diseases, Rare diseases, Immune diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 59
Lupus Erythematosus, Subacute Cutaneous 73
Lupus Erythematosus Cutaneous Subacute 55

Characteristics:

Orphanet epidemiological data:

59
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA163525
ICD10 via Orphanet 34 L93.1
UMLS via Orphanet 74 C0024140
ICD10 33 L93.1
UMLS 73 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and connective tissue disease. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Alitretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lung.

Wikipedia : 76 Subacute cutaneous lupus erythematosus (SCLE) is a clinically distinct subset of cases of lupus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Subacute Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 31.0 EEA1 TNF TRIM21
2 connective tissue disease 28.3 ACE TNF
3 neonatal lupus erythematosus 11.6
4 lupus erythematosus 11.1
5 systemic lupus erythematosus 10.3
6 arthritis 10.2
7 porphyria cutanea tarda 10.2
8 rheumatoid arthritis 10.2
9 porphyria 10.2
10 psoriasis 10.2
11 vasculitis 10.2
12 leprosy 3 10.1 MBD1 TNF
13 discoid lupus erythematosus 10.1
14 sialadenitis 10.1 TNF TRIM21
15 lacrimal apparatus disease 10.0 TNF TRIM21
16 exanthem 10.0 TNF TRIM21
17 cogan syndrome 10.0 TNF TRIM21
18 annular erythema 10.0
19 squamous cell carcinoma 10.0
20 hepatitis 10.0
21 lichen planus 10.0
22 myositis 10.0
23 erythema multiforme 10.0
24 adenocarcinoma 10.0
25 tinea corporis 10.0
26 complement component 2 deficiency 10.0
27 neuropathy 10.0
28 rheumatic disease 9.9 TNF TRIM21
29 hepatocellular carcinoma 9.9
30 crohn's disease 9.9
31 hepatitis c 9.9
32 molluscum contagiosum 9.9
33 renal cell carcinoma, nonpapillary 9.9
34 melanoma 9.9
35 inclusion body myositis 9.9
36 hepatitis b 9.9
37 dermatitis 9.9
38 skin disease 9.9
39 epidermolysis bullosa 9.9
40 keratoconjunctivitis 9.9
41 acute pancreatitis 9.9
42 myositis fibrosa 9.9
43 pityriasis rubra pilaris 9.9
44 lichen planus pemphigoides 9.9
45 methemoglobinemia 9.9
46 mixed connective tissue disease 9.9
47 polymyositis 9.9
48 gastric adenocarcinoma 9.9
49 tièche-jadassohn nevus 9.9
50 keratoconjunctivitis sicca 9.9

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
2
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
3 Dermatologic Agents Phase 2,Not Applicable
4 Keratolytic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of KRP203 in Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 Study to Evaluate BIIB059 in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) Recruiting NCT02847598 Phase 2 BIIB059;Placebo
4 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Terminated NCT01407679 Phase 2 Alitretinoin
5 Safety Study of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
6 Pilot Tape Harvesting Study Completed NCT02125695
7 A Non-drug Study Profiling Cutaneous Lupus Completed NCT01923415
8 A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344
9 The Human Microbiome in Immune-Mediated Diseases Recruiting NCT02394964
10 Cutaneous Lupus Erythematosus and Elidel Withdrawn NCT00222183 Not Applicable Elidel (pimecrolimus)

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

41
Skin, T Cells, Lung, Colon, Testes, Prostate, Liver

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 315)
# Title Authors Year
1
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger? ( 29327459 )
2018
2
Subacute Cutaneous Lupus Erythematosus Induced by Palbociclib. ( 29307217 )
2018
3
Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol. ( 29782299 )
2018
4
Subacute cutaneous lupus erythematosus presenting in twins. ( 29436018 )
2018
5
The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. ( 29631513 )
2018
6
Occupational subacute cutaneous lupus erythematosus caused by outdoor work. ( 29603599 )
2018
7
Rituximab in the treatment of extensive and refractory subacute cutaneous lupus erythematosus. ( 29924233 )
2018
8
Successful treatment of severe subacute cutaneous lupus erythematosus with rituximab in an adolescent. ( 29570834 )
2018
9
An update in drug-induced subacute cutaneous lupus erythematosus. ( 28329511 )
2017
10
Subacute cutaneous lupus erythematosus - paraneoplastic to gastric adenocarcinoma? ( 28421344 )
2017
11
Subacute cutaneous lupus erythematosus induced by masitinib. ( 28940367 )
2017
12
Subacute Cutaneous Lupus Erythematosus: Clinical Characteristics, Disease Associations, Treatments, and Outcomes in a Series of 90A Patients at Mayo Clinic, 1996-2011. ( 28185656 )
2017
13
Rowell's Syndrome or subacute cutaneous lupus erythematosus? ( 27978611 )
2017
14
Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. ( 28331627 )
2017
15
Subacute cutaneous lupus erythematosus induced by nivolumab. ( 28726325 )
2017
16
Proton Pump Inhibitor-Associated Subacute Cutaneous Lupus Erythematosus in a Patient With Granulomatosis With Polyangiitis. ( 27870768 )
2016
17
Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. ( 27888319 )
2016
18
Using the American College of Rheumatology (ACR) and Systemic Lupus International Collaborating Clinics (SLICC) criteria to determine the diagnosis of systemic lupus erythematosus (SLE) in patients with subacute cutaneous lupus erythematosus (SCLE). ( 26897388 )
2016
19
Subacute cutaneous lupus erythematosus. ( 27286780 )
2016
20
First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer. ( 27836354 )
2016
21
Lenalidomide for refractory chronic and subacute cutaneous lupus erythematosus: 16 patients. ( 27185425 )
2016
22
Gemcitabine-Induced Subacute Cutaneous Lupus Erythematosus: A Case Report. ( 26928175 )
2016
23
Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Proton Pump Inhibitors. ( 27398293 )
2016
24
Rare Occurrence of Drug Induced Subacute Cutaneous Lupus Erythematosus with Leflunomide Therapy. ( 27891379 )
2016
25
Anastrozole-induced subacute cutaneous lupus erythematosus. ( 27622265 )
2016
26
Dermoscopy of subacute cutaneous lupus erythematosus. ( 27260752 )
2016
27
Voriconazole-Induced Subacute Cutaneous Lupus Erythematosus in an Adult With Aspergillosis. ( 28031137 )
2016
28
Docetaxel-induced-like subacute cutaneous lupus erythematosus. ( 26350359 )
2015
29
Subacute cutaneous lupus erythematosus induced by lansoprazole. ( 25855412 )
2015
30
Minocycline: a new molecule inducing subacute cutaneous lupus erythematosus? ( 25876148 )
2015
31
Subacute Cutaneous Lupus Erythematosus Induced by Mitotane. ( 26444320 )
2015
32
Imiquimod-induced subacute cutaneous lupus erythematosus-like changes. ( 26125212 )
2015
33
Subacute cutaneous lupus erythematosus induced by capecitabine: 5-FU was innocent. ( 26551520 )
2015
34
Subacute cutaneous lupus erythematosus starting as linear lupus erythematosus. ( 26235783 )
2015
35
Drug-Induced Subacute Cutaneous Lupus Erythematosus in a Patient Receiving Therapy for Chronic Hepatitis C. ( 26539906 )
2015
36
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
37
Subacute cutaneous lupus erythematosus associated with pemetrexed plus Carboplatin chemotherapy. ( 25417687 )
2014
38
Pediatric subacute cutaneous lupus erythematosus: report of three cases. ( 25209420 )
2014
39
An uncommon cutaneous reaction for a common drug. Diagnosis: Drug-induced subacute cutaneous lupus erythematosus (DI-SCLE). ( 25244994 )
2014
40
Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report. ( 25369825 )
2014
41
Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease. ( 24520513 )
2014
42
Paraneoplastic subacute cutaneous lupus erythematosus associated with cholangiocarcinoma. ( 25367767 )
2014
43
Proton pump inhibitors and subacute cutaneous lupus erythematosus: an under-recognized phenomenon? ( 24547716 )
2014
44
Subacute cutaneous lupus erythematosus induced by the new multikinase inhibitor pazopanib. ( 24909204 )
2014
45
Proton pump inhibitor-induced subacute cutaneous lupus erythematosus. ( 24547721 )
2014
46
What is your diagnosis? subacute cutaneous lupus erythematosus. ( 24818184 )
2014
47
Subacute cutaneous lupus erythematosus: a paraneoplastic phenomenon in oropharyngeal squamous cell carcinoma. ( 25284285 )
2014
48
Subacute cutaneous lupus erythematosus presenting as erythroderma. ( 25484433 )
2014
49
The concurrence of subacute cutaneous lupus erythematosus and hand-foot syndrome in a patient undergoing capecitabine chemotherapy. ( 25495707 )
2014
50
Terbinafine-induced subacute cutaneous lupus erythematosus in two patients with systemic lupus erythematosus successfully treated with topical corticosteroids. ( 24278085 )
2013

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.19 ACE TNF
2 10.84 MBD1 TNF

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 EEA1 TNF

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA binding transcription factor activity GO:0051091 8.62 TNF TRIM21

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.92 ACE EEA1 MBD1 TRIM21

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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