MCID: SBC035
MIFTS: 32

Subacute Cutaneous Lupus Erythematosus

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 58 32
Lupus Erythematosus, Subacute Cutaneous 71
Lupus Erythematosus Cutaneous Subacute 54

Characteristics:

Orphanet epidemiological data:

58
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L93.1
ICD10 via Orphanet 33 L93.1
UMLS via Orphanet 72 C0024140
Orphanet 58 ORPHA163525
UMLS 71 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways is Pertussis. The drug Alitretinoin has been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast.

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Rare Cutaneous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 227)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 32.0 TRIM21 TNF
2 lupus erythematosus 31.3 TRIM21 TNF C1QA
3 keratoconjunctivitis sicca 30.2 TRIM21 TNF
4 exanthem 30.0 TRIM21 TNF ACE
5 purpura 30.0 TNF ACE
6 keratoconjunctivitis 30.0 TRIM21 TNF
7 systemic lupus erythematosus 29.4 TRIM21 TNF C1QA ACE
8 systemic scleroderma 29.1 TRIM21 TNF ACE
9 neonatal lupus erythematosus 11.9
10 rare cutaneous lupus erythematosus 10.8
11 skin disease 10.6
12 autoimmune disease 10.5
13 discoid lupus erythematosus 10.5
14 vasculitis 10.5
15 erythema multiforme 10.4
16 enthesopathy 10.4
17 connective tissue disease 10.4
18 pustulosis of palm and sole 10.4
19 psoriasis 10.4
20 myositis 10.4
21 porphyria cutanea tarda 10.4
22 porphyria 10.4
23 lichen planus 10.4
24 annular erythema 10.3
25 rheumatoid arthritis 10.3
26 drug-induced lupus erythematosus 10.3
27 dermatomyositis 10.3
28 alopecia 10.3
29 stevens-johnson syndrome/toxic epidermal necrolysis 10.3
30 raynaud phenomenon 10.3
31 breast cancer 10.2
32 dowling-degos disease 1 10.2
33 complement component 2 deficiency 10.2
34 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
35 chilblain lupus 1 10.2
36 neutropenia 10.2
37 thrombocytopenia 10.2
38 complement deficiency 10.2
39 dermatophytosis 10.2
40 prostate cancer 10.2
41 vitiligo-associated multiple autoimmune disease susceptibility 6 10.2
42 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2
43 aspergillosis 10.2
44 invasive aspergillosis 10.2
45 anogenital venereal wart 10.2
46 tinea corporis 10.2
47 panniculitis 10.2
48 lymphadenitis 10.2
49 keratosis 10.2
50 hepatitis c 10.2

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 449171 444795

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Double-blind, Placebo-controlled, Proof-of-concept Study to Evaluate the Efficacy and Tolerability of KRP203 in Patients With Active Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 A Phase 2, Pilot, Multicenter, Sequential, Ascending Dose Study to Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 A 2-Part Phase 2 Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of BIIB059 in Subjects With Systemic Lupus Erythematosus and Active Skin Manifestations and in Subjects With Active Cutaneous Lupus Erythematosus With or Without Systemic Manifestations Completed NCT02847598 Phase 2 BIIB059;Placebo
4 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus: A Multicentre, Open-Label, Prospective Pilot Study Terminated NCT01407679 Phase 2 Alitretinoin
5 A Randomized, Double-blind, Placebo-controlled, Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
6 Longitudinal Study of Skin And Systemic Biomarkers In Subjects With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344
7 Cross-Sectional Study in Subjects With Active Cutaneous Lupus Erythematosus Completed NCT01923415
8 A Pilot Study to Evaluate Using Tape Harvesting to Collect Ribonucleic Acid From the Upper Epidermis of Healthy Volunteers and Subjects With Discoid Lupus, Subjects With Subacute Cutaneous Lupus, and Subjects With Atopic Dermatitis Completed NCT02125695
9 Telangiectatic Palmoplantar Keratoderma in Systemic and Subacute Lupus Erythematosus : to a Form of Lichen Planus-like Lupus Erythematosus ? Active, not recruiting NCT04356014
10 Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE) Withdrawn NCT00222183 Elidel (pimecrolimus)

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

40
Skin, T Cells, Breast, Lung, B Cells, Liver, Thyroid

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 610)
# Title Authors PMID Year
1
Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. 61 54
12485445 2002
2
[Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by paraneoplastic subacute cutaneous lupus erythematosus]. 54 61
10584550 1999
3
Disparate locations of the 52- and 60-kDa Ro/SS-A antigens in cultured human keratinocytes. 54 61
8823371 1996
4
Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. 54 61
8676889 1996
5
Subacute cutaneous lupus erythematosus with positive anti-Ro antibodies following palbociclib and letrozole treatment: A case report and literature review. 61
32119141 2020
6
Three cases of subacute cutaneous lupus erythematosus associated with malignancy: a late paraneoplastic phenomenon. 61
31944366 2020
7
Childhood subacute cutaneous lupus erythematosus associated with transaminitis. 61
31850540 2020
8
Subacute cutaneous lupus erythematosus with melanocyte elimination induced by pembrolizumab. 61
32173880 2020
9
Secukinumab-induced subacute cutaneous lupus erythematosus. 61
32291870 2020
10
Discoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review. 61
32467803 2020
11
Successful ustekinumab treatment in a patient with psoriasis and subacute cutaneous lupus erythematosus. 61
31957866 2020
12
Cutaneous effects of antihypertensive drugs. 61
31195782 2020
13
Anastrozole-Induced Dermatitis: Report of a Woman with an Anastrozole-Associated Dermatosis and a Review of Aromatase Inhibitor-Related Cutaneous Adverse Events. 61
31965545 2020
14
Metastatic prostate cancer presenting as subacute cutaneous lupus erythematosus. 61
31407804 2020
15
Proton Pump Inhibitor-Induced Subacute Cutaneous Lupus Erythematosus. 61
31427196 2020
16
Drug-induced anti-Ro positive subacute cutaneous lupus in a man treated with olmesartan. 61
32045161 2019
17
Subacute cutaneous lupus erythematosus leukoderma treated with melanocyte-keratinocyte transplantation procedure. 61
30932304 2019
18
Clinicopathologic comparison of Rowell syndrome, erythema multiforme, and subacute cutaneous lupus erythematosus. 61
31629618 2019
19
Subacute cutaneous lupus erythematosus with a possible paraneoplastic association with melanoma. 61
31780613 2019
20
Systemic 5-fluorouracil induced lupus erythematosus: a review of the literature. 61
32045142 2019
21
Widespread subacute cutaneous lupus erythematosus in a patient receiving checkpoint inhibitor immunotherapy with ipilimumab and nivolumab. 61
31735010 2019
22
Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma. 61
31611227 2019
23
UV radiation exposure in welders: impact on the skin and eyes. 61
31675405 2019
24
Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy. 61
30244487 2019
25
Capecitabine-induced Subacute Cutaneous Lupus Erythematosus. 61
31777367 2019
26
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis-Like Lupus Erythematosus. 61
29912772 2019
27
Are there distinct clinical and pathological features distinguishing idiopathic from drug-induced subacute cutaneous lupus erythematosus? A European retrospective multicenter study. 61
30763648 2019
28
[Immunohistochemical analysis for C3d, C4d, IgG, IgG4, and CD123 in diagnosis of autoimmune skin diseases]. 61
31570674 2019
29
Subacute cutaneous lupus erythematosus induced by gemcitabine in 2 patients with pancreatic cancer. 61
31317065 2019
30
Rowell's Syndrome Triggered by Omeprazole. 61
31351509 2019
31
Dapsone: an old drug effective for subacute cutaneous lupus erythematosus. 61
30615176 2019
32
Subacute Cutaneous Lupus Erythematosus in a Male Patient on Multiple Antiepileptics Unmasked by Melatonin. 61
31136412 2019
33
Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review. 61
30489484 2019
34
Subacute cutaneous lupus erythematosus triggered by an antiviral treatment combination for hepatitis C virus infection. 61
30394571 2019
35
Primary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature. 61
30921233 2019
36
When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. 61
30613100 2019
37
MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus. 61
30130620 2019
38
Subacute cutaneous lupus erythematosus observed with ciprofloxacin. 61
30580309 2018
39
[When drugs induce cutaneous lupus erythematosus]. 61
30327081 2018
40
Drug-induced lupus erythematosus: an update on drugs and mechanisms. 61
29870500 2018
41
Annular Lesions: Diagnosis and Treatment. 61
30216021 2018
42
Subacute cutaneous lupus erythematosus and systemic lupus erythematosus associated with abatacept. 61
30167444 2018
43
The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. 61
29631513 2018
44
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger? 61
29327459 2018
45
Cutaneous lupus erythematosus: Reflecting on practice-changing observations over the past 50 years. 61
30047428 2018
46
Rituximab in the treatment of extensive and refractory subacute cutaneous lupus erythematosus. 61
29924233 2018
47
Case of severe acute lupus myocarditis and multiple-organ failure. 61
29925558 2018
48
Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: report of a case and review of the literature. 61
30142736 2018
49
Successful treatment of severe subacute cutaneous lupus erythematosus with rituximab in an adolescent. 61
29570834 2018
50
Subacute cutaneous lupus erythematosus induced by nivolumab. 61
28726325 2018

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.5 TNF C1QA

GO Terms for Subacute Cutaneous Lupus Erythematosus

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.16 TRIM21 TNF
2 microglial cell activation GO:0001774 8.96 TNF C1QA
3 astrocyte activation GO:0048143 8.62 TNF C1QA

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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