MCID: SBC035
MIFTS: 34

Subacute Cutaneous Lupus Erythematosus

Categories: Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Subacute Cutaneous Lupus Erythematosus

MalaCards integrated aliases for Subacute Cutaneous Lupus Erythematosus:

Name: Subacute Cutaneous Lupus Erythematosus 59 33
Lupus Erythematosus, Subacute Cutaneous 72
Lupus Erythematosus Cutaneous Subacute 55

Characteristics:

Orphanet epidemiological data:

59
subacute cutaneous lupus erythematosus
Prevalence: 1-9/1000000 (United States);

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

ICD10 33 L93.1
ICD10 via Orphanet 34 L93.1
UMLS via Orphanet 73 C0024140
Orphanet 59 ORPHA163525
UMLS 72 C0024140

Summaries for Subacute Cutaneous Lupus Erythematosus

MalaCards based summary : Subacute Cutaneous Lupus Erythematosus, also known as lupus erythematosus, subacute cutaneous, is related to cutaneous lupus erythematosus and lupus erythematosus. An important gene associated with Subacute Cutaneous Lupus Erythematosus is TRIM21 (Tripartite Motif Containing 21), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Tuberculosis. The drug Alitretinoin has been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast.

Wikipedia : 75 Subacute cutaneous lupus erythematosus is a clinically distinct subset of cases of lupus erythematosus... more...

Related Diseases for Subacute Cutaneous Lupus Erythematosus

Diseases in the Cutaneous Lupus Erythematosus family:

Rare Cutaneous Lupus Erythematosus Subacute Cutaneous Lupus Erythematosus
Chronic Cutaneous Lupus Erythematosus

Diseases related to Subacute Cutaneous Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 cutaneous lupus erythematosus 31.4 TRIM21 TNF EEA1
2 lupus erythematosus 31.3 TRIM21 TNF C1QA
3 exanthem 30.9 TRIM21 TNF
4 rheumatic disease 30.3 TRIM21 TNF
5 systemic scleroderma 29.4 TRIM21 ACE
6 connective tissue disease 29.4 TNF ACE
7 nervous system disease 29.3 TNF ACE
8 systemic lupus erythematosus 29.3 TRIM21 TNF C1QA ACE
9 cerebrovascular disease 29.2 TNF ACE
10 neonatal lupus erythematosus 11.9
11 rare cutaneous lupus erythematosus 10.8
12 skin disease 10.6
13 discoid lupus erythematosus 10.5
14 autoimmune disease 10.5
15 vasculitis 10.5
16 enthesopathy 10.4
17 erythema multiforme 10.4
18 porphyria cutanea tarda 10.4
19 porphyria 10.4
20 pustulosis of palm and sole 10.4
21 psoriasis 10.4
22 lichen planus 10.4
23 annular erythema 10.3
24 myositis 10.3
25 drug-induced lupus erythematosus 10.3
26 dermatomyositis 10.3
27 alopecia 10.3
28 raynaud phenomenon 10.3
29 breast cancer 10.2
30 dowling-degos disease 1 10.2
31 rheumatoid arthritis 10.2
32 complement component 2 deficiency 10.2
33 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
34 chilblain lupus 1 10.2
35 neutropenia 10.2
36 thrombocytopenia 10.2
37 purpura 10.2
38 complement deficiency 10.2
39 arthritis 10.2
40 dermatophytosis 10.2
41 stevens-johnson syndrome/toxic epidermal necrolysis 10.2
42 prostate cancer 10.2
43 aspergillosis 10.2
44 invasive aspergillosis 10.2
45 anogenital venereal wart 10.2
46 tinea corporis 10.2
47 keratoconjunctivitis sicca 10.2
48 panniculitis 10.2
49 lymphadenitis 10.2
50 keratosis 10.2

Graphical network of the top 20 diseases related to Subacute Cutaneous Lupus Erythematosus:



Diseases related to Subacute Cutaneous Lupus Erythematosus

Symptoms & Phenotypes for Subacute Cutaneous Lupus Erythematosus

Drugs & Therapeutics for Subacute Cutaneous Lupus Erythematosus

Drugs for Subacute Cutaneous Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multi-center, Double-blind, Placebo-controlled, Proof-of-concept Study to Evaluate the Efficacy and Tolerability of KRP203 in Patients With Active Subacute Cutaneous Lupus Erythematosus Completed NCT01294774 Phase 2 KRP203 - 1.2mg;Placebo to KRP203 - 1.2 mg
2 A Phase 2, Pilot, Multicenter, Sequential, Ascending Dose Study to Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
3 A 2-Part Phase 2 Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of BIIB059 in Subjects With Systemic Lupus Erythematosus and Active Skin Manifestations and in Subjects With Active Cutaneous Lupus Erythematosus With or Without Systemic Manifestations Active, not recruiting NCT02847598 Phase 2 BIIB059;Placebo
4 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus: A Multicentre, Open-Label, Prospective Pilot Study Terminated NCT01407679 Phase 2 Alitretinoin
5 A Randomized, Double-blind, Placebo-controlled, Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of AMG 557 in Subjects With Subacute Cutaneous Lupus Erythematosus Terminated NCT01389895 Phase 1 AMG 557;AMG 557 Placebo
6 Longitudinal Study of Skin And Systemic Biomarkers In Subjects With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344
7 Cross-Sectional Study in Subjects With Active Cutaneous Lupus Erythematosus Completed NCT01923415
8 A Pilot Study to Evaluate Using Tape Harvesting to Collect Ribonucleic Acid From the Upper Epidermis of Healthy Volunteers and Subjects With Discoid Lupus, Subjects With Subacute Cutaneous Lupus, and Subjects With Atopic Dermatitis Completed NCT02125695
9 Evaluation of the Therapeutic Effect and Local Tolerability of Elidel® Cream 1% (Pimecrolimus) in Chronic Discoid Lupus Erythematosus (dLE) or Subacute Cutaneous Lupus Erythematosus (scLE) Withdrawn NCT00222183 Elidel (pimecrolimus)

Search NIH Clinical Center for Subacute Cutaneous Lupus Erythematosus

Genetic Tests for Subacute Cutaneous Lupus Erythematosus

Anatomical Context for Subacute Cutaneous Lupus Erythematosus

MalaCards organs/tissues related to Subacute Cutaneous Lupus Erythematosus:

41
Skin, T Cells, Breast, B Cells, Lung, Liver, Thyroid

Publications for Subacute Cutaneous Lupus Erythematosus

Articles related to Subacute Cutaneous Lupus Erythematosus:

(show top 50) (show all 593)
# Title Authors PMID Year
1
Mannose binding lectin (MBL) polymorphisms associated with low MBL production in patients with dermatomyositis. 9 38
12485445 2002
2
[Cutaneous paraneoplastic syndrome as an immunologic phenomenon exemplified by paraneoplastic subacute cutaneous lupus erythematosus]. 9 38
10584550 1999
3
Disparate locations of the 52- and 60-kDa Ro/SS-A antigens in cultured human keratinocytes. 9 38
8823371 1996
4
Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. 9 38
8676889 1996
5
Are there distinct clinical and pathological features distinguishing idiopathic from drug-induced subacute cutaneous lupus erythematosus? A European retrospective multicenter study. 38
30763648 2019
6
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis-Like Lupus Erythematosus. 38
29912772 2019
7
Metastatic prostate cancer presenting as subacute cutaneous lupus erythematosus. 38
31407804 2019
8
Proton Pump Inhibitor-Induced Subacute Cutaneous Lupus Erythematosus. 38
31427196 2019
9
Subacute cutaneous lupus erythematosus induced by gemcitabine in 2 patients with pancreatic cancer. 38
31317065 2019
10
Cutaneous effects of antihypertensive drugs. 38
31195782 2019
11
Rowell's Syndrome Triggered by Omeprazole. 38
31351509 2019
12
Subacute Cutaneous Lupus Erythematosus in a Male Patient on Multiple Antiepileptics Unmasked by Melatonin. 38
31136412 2019
13
Subacute cutaneous lupus erythematosus induced by nivolumab: two case reports and a literature review. 38
30489484 2019
14
Subacute cutaneous lupus erythematosus leukoderma treated with melanocyte-keratinocyte transplantation procedure. 38
30932304 2019
15
Subacute cutaneous lupus erythematosus triggered by an antiviral treatment combination for hepatitis C virus infection. 38
30394571 2019
16
Primary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature. 38
30921233 2019
17
When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. 38
30613100 2019
18
Dapsone: an old drug effective for subacute cutaneous lupus erythematosus. 38
30615176 2019
19
MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus. 38
30130620 2019
20
Subacute cutaneous lupus erythematosus observed with ciprofloxacin. 38
30580309 2018
21
[When drugs induce cutaneous lupus erythematosus]. 38
30327081 2018
22
Annular Lesions: Diagnosis and Treatment. 38
30216021 2018
23
Drug-induced lupus erythematosus: an update on drugs and mechanisms. 38
29870500 2018
24
Subacute cutaneous lupus erythematosus and dermatomyositis associated with anti-programmed cell death 1 therapy. 38
30244487 2018
25
Subacute cutaneous lupus erythematosus and systemic lupus erythematosus associated with abatacept. 38
30167444 2018
26
The devil's in the dosing: severe drug-induced liver injury in a hydroxychloroquine-naive patient with subacute cutaneous lupus erythematosus and porphyria cutanea tarda. 38
29631513 2018
27
Cutaneous lupus erythematosus: Reflecting on practice-changing observations over the past 50 years. 38
30047428 2018
28
Subacute cutaneous lupus erythematosus: is clopidogrel a trigger? 38
29327459 2018
29
Rituximab in the treatment of extensive and refractory subacute cutaneous lupus erythematosus. 38
29924233 2018
30
Case of severe acute lupus myocarditis and multiple-organ failure. 38
29925558 2018
31
Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus: report of a case and review of the literature. 38
30142736 2018
32
Successful treatment of severe subacute cutaneous lupus erythematosus with rituximab in an adolescent. 38
29570834 2018
33
Subacute Cutaneous Lupus Erythematosus Induced by Palbociclib. 38
29307217 2018
34
Subacute cutaneous lupus erythematosus induced by nivolumab. 38
28726325 2018
35
Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol. 38
29782299 2018
36
Occupational subacute cutaneous lupus erythematosus caused by outdoor work. 38
29603599 2018
37
Subacute cutaneous lupus erythematosus presenting in twins. 38
29436018 2018
38
[Secukinumab-induced subacute-cutaneous lupus erythematosus]. 38
29075868 2018
39
Two cases of annular erythema without bullous lesions by autoimmune blistering diseases. 38
26382039 2018
40
Isoniazid-induced subacute cutaneous lupus erythematosus in an HIV-positive woman: a rare side effect to be aware of with the current expansion of isoniazid preventive therapy. 38
30061978 2018
41
Drug-induced Rowell syndrome, a rare and difficult to manage disease: A case report. 38
29434682 2018
42
Subacute cutaneous lupus erythematosus induced by masitinib. 38
28940367 2017
43
Bullous Pemphigoid Masquerading as Erythema Annulare Centrifugum. 38
29252183 2017
44
First case of paraneoplastic subacute cutaneous lupus erythematosus associated with colon cancer. 38
27836354 2017
45
Cutaneous Lupus: A Brief Review of Old and New Medical Therapeutic Options. 38
28941497 2017
46
[Esomeprazol-induced cutaneous lupus erythematosus]. 38
29186640 2017
47
[Subacute cutaneous lupus erythematosus induced by 5-fluorouracil]. 38
28666566 2017
48
Subacute cutaneous lupus erythematosus - paraneoplastic to gastric adenocarcinoma? 38
28421344 2017
49
Lansoprazole-Induced Subacute Cutaneous Lupus Erythematosus. 38
30375575 2017
50
Subacute cutaneous lupus erythematosus inducing unilateral sensorimotor neuropathy. 38
27888319 2017

Variations for Subacute Cutaneous Lupus Erythematosus

Expression for Subacute Cutaneous Lupus Erythematosus

Search GEO for disease gene expression data for Subacute Cutaneous Lupus Erythematosus.

Pathways for Subacute Cutaneous Lupus Erythematosus

Pathways related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.07 TNF C1QA ACE
2 11.51 TNF EEA1
3
Show member pathways
11.43 TNF ACE
4 10.5 TNF C1QA

GO Terms for Subacute Cutaneous Lupus Erythematosus

Cellular components related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 recycling endosome GO:0055037 8.62 TNF EEA1

Biological processes related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 8.62 TRIM21 TNF

Molecular functions related to Subacute Cutaneous Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.8 TRIM21 EEA1 ACE

Sources for Subacute Cutaneous Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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