Subacute Lymphocytic Thyroiditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Subacute Lymphocytic Thyroiditis

MalaCards integrated aliases for Subacute Lymphocytic Thyroiditis:

Name: Subacute Lymphocytic Thyroiditis ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7187

NCIt ⁵⁰ C35829

SNOMED-CT ⁶⁷ 361126006

UMLS ⁷⁰ C1306804

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Summaries for Subacute Lymphocytic Thyroiditis

MalaCards based summary : Subacute Lymphocytic Thyroiditis is related to graves disease 1 and thyroid carcinoma. An important gene associated with Subacute Lymphocytic Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include thyroid, lung and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : ⁷³ Subacute lymphocytic thyroiditis is a form of thyroiditis. Subacute lymphocytic thyroiditis may occur at... more...

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Related Diseases for Subacute Lymphocytic Thyroiditis

Diseases related to Subacute Lymphocytic Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)

#	Related Disease	Score	Top Affiliating Genes
1	graves disease 1	30.2	TSHR TPO TG
2	thyroid carcinoma	30.2	TSHR TPO TG
3	hyperthyroidism	30.2	TSHR TPO TG
4	thyroiditis	29.9	TSHR TPO TG IL2
5	hypothyroidism	29.9	TSHR TPO TG IL2
6	acute thyroiditis	10.3	TPO TG
7	mechanical strabismus	10.3	TPO TG
8	nonencapsulated sclerosing carcinoma	10.3	TPO TG
9	aspirin allergy	10.3	TPO TG
10	postsurgical hypothyroidism	10.3	TPO TG
11	goiter, multinodular 1, with or without sertoli-leydig cell tumors	10.3	TPO TG
12	struma ovarii	10.3	TSHR TG
13	transient congenital hypothyroidism	10.3	TSHR TPO
14	athyreosis	10.3	TSHR TG
15	hypotropia	10.3	TSHR TPO
16	papillary thyroid microcarcinoma	10.3	TSHR TG
17	type 1 diabetes mellitus 20	10.2	TPO TG
18	dendritic cell thymoma	10.2	TG CD4
19	adrenal cortical hypofunction	10.2	TPO TG
20	hyperthyroxinemia	10.2	TSHR TPO
21	anal spasm	10.2	TG CD4
22	thyroid hormone resistance, generalized, autosomal dominant	10.2	TSHR TG
23	iodine hypothyroidism	10.1	TSHR TPO TG
24	goiter	10.1	TSHR TPO TG
25	thyroid crisis	10.1	TSHR TPO TG
26	toxic diffuse goiter	10.1	TSHR TPO TG
27	endemic goiter	10.1	TSHR TPO TG
28	nontoxic goiter	10.1	TSHR TPO TG
29	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	10.1	TSHR TPO TG
30	myxedema	10.1	TSHR TPO TG
31	subacute thyroiditis	10.1	TSHR TPO TG
32	exophthalmos	10.1	TSHR TPO TG
33	hypothyroidism, congenital, nongoitrous, 1	10.1	TSHR TG
34	congenital hypothyroidism	10.1	TSHR TPO TG
35	benign struma ovarii	10.1	TSHR TG TCF21
36	invasive malignant thymoma	10.1	TSHR CD4
37	differentiated thyroid carcinoma	10.1	TSHR TPO TG
38	thyroid lymphoma	10.1	TG FAS
39	hypothyroidism, congenital, nongoitrous, 2	10.1	TSHR TG
40	follicular adenoma	10.1	TSHR TPO TG
41	papillary carcinoma	10.1	TSHR TPO TG
42	thyroid gland follicular carcinoma	10.1	TSHR TPO TG
43	thyroid gland anaplastic carcinoma	10.1	TSHR TPO TG
44	skin sarcoidosis	10.1	IL2 CD4
45	metal allergy	10.1	IL2 CD4
46	gallbladder lymphoma	10.1	CR2 BIRC3
47	oral tuberculosis	10.1	IL2 CD4
48	splenic tuberculosis	10.1	IL2 CD4
49	superficial basal cell carcinoma	10.1	IL2 CD4
50	farmer's lung	10.1	IL2 CD4

Graphical network of the top 20 diseases related to Subacute Lymphocytic Thyroiditis:

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Symptoms & Phenotypes for Subacute Lymphocytic Thyroiditis

MGI Mouse Phenotypes related to Subacute Lymphocytic Thyroiditis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.06	BIRC3 CD4 CR2 FAS FLNB IL2
2	homeostasis/metabolism	MP:0005376	10.03	BIRC3 CD4 CR2 EMP1 FAS FLNB
3	growth/size/body region	MP:0005378	10.02	CD4 FAS FLNB IL2 SELL TCF21
4	endocrine/exocrine gland	MP:0005379	10.01	CD4 FAS IL2 SELL TCF21 TG
5	immune system	MP:0005387	9.9	BIRC3 CD4 CR2 FAS FLNB IL2
6	mortality/aging	MP:0010768	9.65	BIRC3 CD4 CR2 FAS FLNB IL2
7	neoplasm	MP:0002006	9.02	FAS IL2 SELL TCF21 TSHR

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Drugs & Therapeutics for Subacute Lymphocytic Thyroiditis

Search Clinical Trials , NIH Clinical Center for Subacute Lymphocytic Thyroiditis

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Genetic Tests for Subacute Lymphocytic Thyroiditis

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Anatomical Context for Subacute Lymphocytic Thyroiditis

MalaCards organs/tissues related to Subacute Lymphocytic Thyroiditis:

⁴⁰

Thyroid, Lung, Skin

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Publications for Subacute Lymphocytic Thyroiditis

Articles related to Subacute Lymphocytic Thyroiditis:

(show all 11)

#	Title	Authors	PMID	Year
1	Painless thyroiditis associated to thyroid carcinoma: role of initial ultrasonography evaluation. ⁶¹	Valentini RB...Meyer EL	26421671	2016
2	Subacute lymphocytic thyroiditis after lobectomy in a patient with papillary thyroid carcinoma: a case report. ⁶¹	Choi YS...Kim JH	23286248	2013
3	Thyroiditis. ⁶¹	Bindra A...Braunstein GD	16734054	2006
4	[Prevalence of autoimmunological disorders of the thyroid in children in the Białystok population]. ⁶¹	Kretowski A...Kinalska I	17338121	2006
5	[Kikuchi's disease: a case report and literature review]. ⁶¹	Lozano Parras MA...Espinos Perez D	12831299	2003
6	Thyroiditis: differential diagnosis and management. ⁶¹	Slatosky J...Wahba H	10706157	2000
7	Clinical, laboratory, and scintigraphic manifestations of subacute and chronic thyroiditis. ⁶¹	Intenzo CM...Green P	8386991	1993
8	[Painful lymphocytic subacute thyroiditis]. ⁶¹	Cortazar A...Beitia JJ	1552759	1992
9	The various presentations of thyroiditis. Diagnostic considerations. ⁶¹	Hamburger JI	3511814	1986
10	Thyroiditis: a clinical update. ⁶¹	Hay ID	3906289	1985
11	Subacute thyroiditis. ⁶¹	Volpe R	7033979	1981

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Genes for Subacute Lymphocytic Thyroiditis

Genes related to Subacute Lymphocytic Thyroiditis (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TG	Thyroglobulin	Protein Coding	6.35	DISEASES inferred ¹⁵
2	FLNB	Filamin B	Protein Coding	5.97	DISEASES inferred ¹⁵
3	TPO	Thyroid Peroxidase	Protein Coding	5.4	DISEASES inferred ¹⁵
4	TCF21	Transcription Factor 21	Protein Coding	5.32	DISEASES inferred ¹⁵
5	EMP1	Epithelial Membrane Protein 1	Protein Coding	4.5	DISEASES inferred ¹⁵
6	TSHR	Thyroid Stimulating Hormone Receptor	Protein Coding	3.89	DISEASES inferred ¹⁵
7	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	3.76	DISEASES inferred ¹⁵
8	IL2	Interleukin 2	Protein Coding	3.69	DISEASES inferred ¹⁵
9	CR2	Complement C3d Receptor 2	Protein Coding	3.64	DISEASES inferred ¹⁵
10	FAS	Fas Cell Surface Death Receptor	Protein Coding	3.38	DISEASES inferred ¹⁵
11	SELL	Selectin L	Protein Coding	3.22	DISEASES inferred ¹⁵
12	CD4	CD4 Molecule	Protein Coding	3.2	DISEASES inferred ¹⁵

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Variations for Subacute Lymphocytic Thyroiditis

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Expression for Subacute Lymphocytic Thyroiditis

Search GEO for disease gene expression data for Subacute Lymphocytic Thyroiditis.

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Pathways for Subacute Lymphocytic Thyroiditis

Pathways related to Subacute Lymphocytic Thyroiditis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.9	TCF21 IL2 FLNB FAS CD4
2	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.17	TSHR TPO TG IL2 FAS CD4
3	4-1BB Pathway ⁶³ Show member pathways CD27 Pathway ⁶³ CD40 Signaling ⁶³ CMV and MAPK Pathways ⁶³ NF-KappaB Activation by EBV ⁶³ NF-kappaB Activation by Viruses ⁶³ PKR Pathway ⁶³ SUMO Pathway ⁶³ TNFR2 Pathway ⁶³	12.16	FAS CR2 CD4 BIRC3
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.56	SELL IL2 CD4
5	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.2	SELL IL2 CD4
6	Cytokines and Inflammatory Response ¹	10.87	IL2 CD4
7	IL12 signaling mediated by STAT4 ¹	10.82	IL2 CD4
8	Thyroxine (Thyroid Hormone) Production ¹	9.58	TSHR TPO TG

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GO Terms for Subacute Lymphocytic Thyroiditis

Biological processes related to Subacute Lymphocytic Thyroiditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein phosphorylation	GO:0001934	9.5	IL2 FAS CD4
2	immune response	GO:0006955	9.46	IL2 FAS CR2 CD4
3	extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	9.26	IL2 FAS
4	thyroid hormone generation	GO:0006590	8.96	TPO TG
5	hormone biosynthetic process	GO:0042446	8.62	TPO TG

Molecular functions related to Subacute Lymphocytic Thyroiditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	glycosphingolipid binding	GO:0043208	8.62	SELL IL2

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