SSPE
MCID: SBC001
MIFTS: 52

Subacute Sclerosing Panencephalitis (SSPE)

Categories: Immune diseases, Infectious diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Subacute Sclerosing Panencephalitis

MalaCards integrated aliases for Subacute Sclerosing Panencephalitis:

Name: Subacute Sclerosing Panencephalitis 56 12 74 52 53 58 36 54 43 15 17 32
Sspe 56 74 52 58
Dawson Encephalitis 52 58
Dawson Disease 52 53
Van Bogaert's Sclerosing Leukoencephalitis 12
Subacute Sclerosing Leukoencephalopathy 12
Immunosuppressive Measles Encephalitis 12
Subacute Sclerosing Leukoencephalitis 58
Panencephalitis, Subacute Sclerosing 56
Subacute Inclusion Body Encephalitis 58
Van Bogaert Encephalitis 58
Van Bogaert Disease 58

Characteristics:

Orphanet epidemiological data:

58
subacute sclerosing leukoencephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States),1-9/100000 (India); Age of onset: All ages; Age of death: any age;

OMIM:

56
Inheritance:
autosomal recessive


HPO:

31
subacute sclerosing panencephalitis:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:8970
OMIM 56 260470
KEGG 36 H01696
ICD9CM 34 046.2
MeSH 43 D013344
NCIt 49 C85171
SNOMED-CT 67 84196008
ICD10 32 A81.1
ICD10 via Orphanet 33 A81.1
UMLS via Orphanet 72 C0038522
Orphanet 58 ORPHA2806
MedGen 41 C0038522
SNOMED-CT via HPO 68 258211005 45170000
UMLS 71 C0038522

Summaries for Subacute Sclerosing Panencephalitis

NINDS : 53 Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of children and young adults that affects the central nervous system (CNS). It is a slow, but persistent, viral infection caused by defective measles virus. SSPE has been reported from all parts of the world, but it is considered a rare disease in developed countries, with fewer than 10 cases per year reported in the United States. The incidence of SSPE declined by at least 90 percent in countries that have practiced widespread immunization with measles vaccine. The incidence of SSPE is still high in developing countries such as India and Eastern Europe. There is a higher incidence among males than females (male/female: 3/1). Most youngsters with SSPE have a history of measles infection at an early age, usually younger than 2 years, followed by a latent period of 6 to 8 years before neurological symptoms begin. Despite the long interval between the measles infection and the onset of SSPE, researchers think that the infection of the brain occurs soon after the primary bout with measles and progresses slowly. Why it persists and progresses still isn't clear. The initial symptoms of SSPE are subtle and include mild mental deterioration (such as memory loss) and changes in behavior (such as irritability) followed by disturbances in motor function, including uncontrollable involuntary jerking movements of the head, trunk or limbs called myoclonic jerks. Seizures may also occur. Some people may become blind. In advanced stages of the disease, individuals may lose the ability to walk, as their muscles stiffen or spasm. There is progressive deterioration to a comatose state, and then to a persistent vegetative state. Death is usually the result of fever, heart failure, or the brain's inability to continue controlling the autonomic nervous system.

MalaCards based summary : Subacute Sclerosing Panencephalitis, also known as sspe, is related to acute disseminated encephalomyelitis and chorioretinitis. An important gene associated with Subacute Sclerosing Panencephalitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include brain, heart and t cells, and related phenotypes are encephalitis and hematopoietic system

Disease Ontology : 12 A viral infectious disease that results in infection located in brain and that has material basis in Measles virus which is immune resistant.

NIH Rare Diseases : 52 Subacute sclerosing panencephalitis (SSPE) a rare condition that is caused by a measles infection acquired earlier in life. Signs and symptoms of the condition primarily affect the central nervous system and often develop approximately 7 to 10 years after a person recovers from the measles. Affected people may initially experience behavioral changes, dementia , and disturbances in motor function. In the late stages of the disease, affected people often progress to a comatose state, and then to a persistent vegetative state. Ultimately, many people with SSPE succumb to fever, heart failure, or the brain's inability to continue controlling the autonomic nervous system . It is unclear why some people develop SSPE after they have seemingly recovered from the measles while others do not. Researchers suspect that SSPE may be due to an abnormal immune response or a mutant form of the measles virus that causes a persistent infection within the central nervous system. Treatment is supportive and primarily based on the signs and symptoms present in each person. Recent studies have shown that certain medications (called antiviral and immunomodulatory drugs) may slow the progression of the condition, although the best treatment regimen and their long-term effects in people with SSPE are currently unknown.

OMIM : 56 Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease caused by persistent central nervous system infection with the measles virus (summary by Torisu et al., 2004). (260470)

KEGG : 36 Subacute sclerosing panencephalitis (SSPE) is a progressive, fatal neurologic disorder of childhood and early adolescence. It is caused by a persistent infection of the brain by an aberrant measles virus. Signs attributable to subacute sclerosing panencephalitis usually develop 4-8 years after the onset of measles infection. It is not precisely known how the measles virus remains dormant for so many years and why it becomes active again. More recent data indicate that it can follow acute measles infection in 1:10,000 cases. The incidence of SSPE is inversely related to measles vaccination coverage. In the developed world, the prevalence of SSPE has steadily declined since the introduction of the measles virus vaccine. The characteristic clinical manifestations of SSPE include behavioral abnormalities, cognitive decline, myoclonic jerks, seizures and abnormalities in vision. Clinical manifestations of SSPE usually start with subtle intellectual deterioration of the affected child causing deterioration in school performance. One of the most characteristic manifestations of SSPE is periodic myoclonic jerks that often leads to difficulty in walking and repeated falls. In the terminal stages of the disease, decerebrate and decorticate rigidity appear. Ultimately the patient becomes vegetative. Management of the disease includes seizure control and avoidance of secondary complications associated with the progressive disability. Treatment with interferon, ribavirin, and isoprinosine have reported beneficial results. However, there is no definitively effective treatment for SSPE.

Wikipedia : 74 Subacute sclerosing panencephalitis (SSPE)-also known as Dawson disease-is a rare form of chronic... more...

Related Diseases for Subacute Sclerosing Panencephalitis

Diseases related to Subacute Sclerosing Panencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 acute disseminated encephalomyelitis 30.8 MOG MBP IL10
2 chorioretinitis 30.6 TNF IL6 IL2 IL10 IFNG
3 aseptic meningitis 30.5 TNF IL10 IFNG
4 toxoplasmosis 30.4 TNF IL6 IL4 IL10 IFNG
5 encephalitis 30.4 TNF TLR3 MX1 MOG IL6 IL10
6 diphtheria 30.3 TNF IL4 IL2 IFNG
7 progressive multifocal leukoencephalopathy 30.2 TNF PDCD1 MBP IL2
8 rabies 30.2 TLR3 MX1 IFNA1
9 optic neuritis 30.2 TNF MOG MBP IL10
10 poliomyelitis 30.1 TNF IL4 IL10 IFNG
11 allergic hypersensitivity disease 30.1 TNF IL4 IL2 IL10 IFNG
12 nervous system disease 30.1 TNF MOG MBP IL6 IFNG
13 measles 30.0 TNF TLR3 SLAMF1 IL6 IL2 IFNG
14 sleep apnea 30.0 TNF IL6 IL10
15 neuromyelitis optica 29.9 MOG MBP IL6 IL4
16 listeriosis 29.9 TNF IL6 IL2 IL10
17 central nervous system disease 29.9 TNF MOG MBP IL6 IFNG
18 cerebral palsy 29.8 TNF IL6 IL10
19 proteasome-associated autoinflammatory syndrome 1 29.8 TNF IL6 IL4 IL10 IFNG
20 osteomyelitis 29.8 TNF IL6 IL4 IL10 IFNG
21 meningoencephalitis 29.7 TNF MBP IL6 IL10
22 hydrocephalus 29.7 TNF MBP IL10 IFNG
23 uveitis 29.6 TNF IL6 IL4 IL2 IL10 IFNG
24 meningitis 29.5 TNF IL6 IL4 IL2 IL10 IFNG
25 herpes simplex 29.5 TNF TLR3 IFNA1 IFIH1
26 neuritis 29.4 TNF MOG MBP IL6 IL4 IL10
27 chickenpox 29.3 TNF TLR3 IL6 IL4 IL2 IL10
28 rubella 29.2 TNF TLR3 MOG IL6 IL4 IL2
29 exanthem 29.2 TNF PDCD1 IL6 IL2 IL10 IFIH1
30 acquired immunodeficiency syndrome 29.1 TNF MBP IL6 IL2 IL10 IFNG
31 stomatitis 29.1 TNF MX1 IL6 IL4 IL2 IL10
32 human immunodeficiency virus type 1 28.8 TNF TLR3 IL6 IL2 IL10 IFNG
33 viral encephalitis 28.8 TNF TLR3 MX1 MOG MBP IL6
34 mumps 28.8 TNF TLR3 MX1 IRF1 IL6 IL2
35 behcet syndrome 28.6 TNF TLR3 IL6 IL4 IL2 IL10
36 demyelinating disease 28.4 TNF MOG MBP IL6 IL4 IL2
37 schizophrenia 28.3 TNF MOG MBP IL6 IL4 IL2
38 common variable immunodeficiency 28.3 TNF IL6 IL4 IL2 IL12RB1 IL10
39 immune deficiency disease 28.3 TNF SLAMF1 IL6 IL4 IL2 IL12RB1
40 peripheral nervous system disease 28.1 TNF MYOM2 MOG MBP IL6 IL4
41 thrombocytopenia 27.8 TNF PDCD1 IL6 IL4 IL2 IL10
42 multiple sclerosis 27.0 TNF TLR3 PDCD1 MX1 MOG MBP
43 autoimmune disease 26.9 TNF PDCD1 MOG MBP IL6 IL4
44 viral infectious disease 26.3 TNF TLR3 SLAMF1 PDCD1 MX1 IRF1
45 prion disease 11.1
46 myoclonus 11.0
47 neuroretinitis 10.7
48 retinitis 10.7
49 ataxia and polyneuropathy, adult-onset 10.7
50 encephalopathy 10.7

Graphical network of the top 20 diseases related to Subacute Sclerosing Panencephalitis:



Diseases related to Subacute Sclerosing Panencephalitis

Symptoms & Phenotypes for Subacute Sclerosing Panencephalitis

Human phenotypes related to Subacute Sclerosing Panencephalitis:

31
# Description HPO Frequency HPO Source Accession
1 encephalitis 31 HP:0002383

Symptoms via clinical synopsis from OMIM:

56
Neuro:
subacute sclerosing panencephalitis

Clinical features from OMIM:

260470

MGI Mouse Phenotypes related to Subacute Sclerosing Panencephalitis:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.3 IFIH1 IFNG IL10 IL12RB1 IL2 IL4
2 immune system MP:0005387 10.25 IFIH1 IFNG IL10 IL12RB1 IL2 IL4
3 cellular MP:0005384 10.24 IFIH1 IFNG IL10 IL2 IL4 IL6
4 homeostasis/metabolism MP:0005376 10.21 IFIH1 IFNG IL10 IL12RB1 IL2 IL4
5 endocrine/exocrine gland MP:0005379 10.13 IFNG IL10 IL2 IL4 IL6 IRF1
6 integument MP:0010771 9.97 IFIH1 IFNG IL10 IL12RB1 IL4 IL6
7 liver/biliary system MP:0005370 9.92 IFIH1 IFNG IL10 IL2 IL4 IL6
8 neoplasm MP:0002006 9.86 IFNG IL10 IL2 IL6 IRF1 PDCD1
9 reproductive system MP:0005389 9.81 CD46 IFNG IL10 IL2 IL4 IL6
10 respiratory system MP:0005388 9.56 IFNG IL10 IL2 IL4 IL6 PDCD1
11 vision/eye MP:0005391 9.32 CD46 IFNG IL10 IL2 IL4 IL6

Drugs & Therapeutics for Subacute Sclerosing Panencephalitis

Search Clinical Trials , NIH Clinical Center for Subacute Sclerosing Panencephalitis

Cochrane evidence based reviews: subacute sclerosing panencephalitis

Genetic Tests for Subacute Sclerosing Panencephalitis

Anatomical Context for Subacute Sclerosing Panencephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Subacute Sclerosing Panencephalitis:

19
Brain

MalaCards organs/tissues related to Subacute Sclerosing Panencephalitis:

40
Brain, Heart, T Cells, B Cells, Eye, Lung, Bone

Publications for Subacute Sclerosing Panencephalitis

Articles related to Subacute Sclerosing Panencephalitis:

(show top 50) (show all 2191)
# Title Authors PMID Year
1
Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. 54 61 56
14872030 2004
2
Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis. 61 56
12020266 2002
3
Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of fibroblast interferon. 61 56
6178588 1982
4
A Multinational Survey on Actual Diagnostics and Treatment of Subacute Sclerosing Panencephalitis. 61 52
26479761 2015
5
Analysis of MxA, IL-4, and IRF-1 genes in Filipino patients with subacute sclerosing panencephalitis. 54 61
17177148 2006
6
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. 54 61
16034142 2005
7
Long-term follow-up of a patient with subacute sclerosing panencephalitis successfully treated with intrathecal interferon alpha. 54 61
15862195 2005
8
Expression of the interferon-alpha/beta-inducible MxA protein in brain lesions of subacute sclerosing panencephalitis. 54 61
15337611 2004
9
An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis. 54 61
11950898 2002
10
Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis. 54 61
10751138 2000
11
[Recent advances in the treatment the nervous system disorders with interferon-alpha]. 54 61
10652752 1999
12
Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. 54 61
10378377 1999
13
The cooperative effect of interferon-alpha and ribavirin on subacute sclerosing panencephalitis (SSPE) virus infections, in vitro and in vivo. 54 61
9497070 1998
14
Absence of measles virus receptor (CD46) in lesions of subacute sclerosing panencephalitis brains. 54 61
9386776 1997
15
Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains. 54 61
7732009 1995
16
[A case of subacute sclerosing panencephalitis treated with intraventricular interferon--the side effects of interferon-alpha to the central nervous system]. 54 61
8156718 1994
17
Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitis. 54 61
1372397 1992
18
Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha. 54 61
1996885 1991
19
Neurological Complications of Measles (Rubeola). 61
32034528 2020
20
Anticoagulant treatment for subsegmental pulmonary embolism. 61
32030721 2020
21
Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis. 61
31733567 2020
22
Weak cis and trans Interactions of the Hemagglutinin with Receptors Trigger Fusion Proteins of Neuropathogenic Measles Virus Isolates. 61
31619560 2020
23
Inosine pranobex enhances human NK cell cytotoxicity by inducing metabolic activation and NKG2D ligand expression. 61
31434164 2020
24
Case Report: Subacute Sclerosing Panencephalitis in Pregnancy Mimicking Posterior Reversible Encephalopathy Syndrome. 61
31971157 2020
25
Extensive subpial cortical demyelination is specific to multiple sclerosis. 61
31916298 2020
26
Early-onset Fulminant Subacute Sclerosing Panencephalitis in a Toddler. 61
31937714 2020
27
Subacute Sclerosing Panencephalitis (SSPE) in HIV Infected Child. 61
31933132 2020
28
Clinical presentation and outcomes in elderly patients with symptomatic isolated subsegmental pulmonary embolism. 61
31683107 2019
29
Measles Encephalitis: Towards New Therapeutics. 61
31684034 2019
30
High risk of subacute sclerosing panencephalitis following measles outbreaks in Georgia. 61
31707133 2019
31
Role of the Th1 and Th17 Pathway in Subacute Sclerosing Panencephalitis. 61
31309861 2019
32
Electrolyte-Solvent-Modified Alternating Copolymer as a Single-Ion Solid Polymer Electrolyte for High-Performance Lithium Metal Batteries. 61
31498586 2019
33
Isolated and Asymmetric Basal Ganglia Involvement in Early Subacute Sclerosing Panencephalitis. 61
31736577 2019
34
Teaching Video NeuroImages: Slow periodic myoclonus in subacute sclerosing panencephalitis and fulminant Wilson disease. 61
31570646 2019
35
Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions. 61
30680706 2019
36
Asymmetric bilateral retinitis in patient with subacute sclerosing panencephalitis. 61
31001903 2019
37
Subacute sclerosing panencephalitis. 61
31237061 2019
38
Substantial Remission in Subacute Sclerosing Panencephalitis by Following the Ketogenic Diet: A Case Report. 61
31489275 2019
39
Early-Onset Subacute Sclerosing Panencephalitis: Report of Two Cases and Review of Literature. 61
31359965 2019
40
Senile-Onset Subacute Sclerosing Panencephalitis, Presenting With Peculiar Findings. 61
30099908 2019
41
Case Report: Subacute Sclerosing Panencephalitis Presenting as Acute Encephalitis. 61
31134883 2019
42
Using bivariate linear mixed models to monitor the change in spatial distribution of heavy metals at the site of a historic landfill. 61
31256242 2019
43
Adult-Onset Subacute Sclerosing Panencephalitis Presented with Neuropsychiatric Symptoms. 61
31142413 2019
44
Maintaining Concentration of Ribavirin in Cerebrospinal Fluid by a New Dosage Method; 3 Cases of Subacute Sclerosing Panencephalitis Treated Using a Subcutaneous Continuous Infusion Pump. 61
30153227 2019
45
Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route. 61
30728259 2019
46
Re-emergence of SSPE: Consequence of the decline of adherence to vaccination programmes? 61
30616885 2019
47
Fulminant Subacute Sclerosing Panencephalitis Mimicking Autoimmune Encephalitis. 61
30762710 2019
48
Teaching Video NeuroImages: An unusual case of fulminant subacute sclerosing panencephalitis. 61
30858250 2019
49
A long-term subacute sclerosing panencephalitis survivor treated with intraventricular interferon-alpha for 13 years. 61
30304904 2019
50
Adsorption Thermodynamics and Dynamics of Three Typical Dyes onto Bio-adsorbent Spent Substrate of Pleurotus eryngii. 61
30813535 2019

Variations for Subacute Sclerosing Panencephalitis

Expression for Subacute Sclerosing Panencephalitis

Search GEO for disease gene expression data for Subacute Sclerosing Panencephalitis.

Pathways for Subacute Sclerosing Panencephalitis

Pathways related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNF TLR3 PDCD1 MX1 IRF1 IL6
2
Show member pathways
13.58 TNF IRF1 IL6 IL4 IL2 IL12RB1
3
Show member pathways
13.42 TNF TLR3 IL6 IL4 IL2 IL12RB1
4
Show member pathways
13.38 TNF MX1 IRF1 IL6 IL4 IL2
5
Show member pathways
13.11 TNF TLR3 MX1 IL6 IL2 IL10
6
Show member pathways
13.04 TNF TLR3 MX1 IRF1 IL6 IL4
7
Show member pathways
12.91 TNF IL6 IL4 IL2 IL10 IFNG
8 12.9 IL6 IL4 IL2 IL12RB1 IFNG IFNA1
9 12.85 TNF TLR3 IL6 IFNG IFNA1 IFIH1
10
Show member pathways
12.82 TNF TLR3 IRF1 IL6 IFNG IFNA1
11
Show member pathways
12.7 TNF IL4 IL2 IL12RB1 IL10 IFNG
12
Show member pathways
12.66 TNF IL6 IL2 IL12RB1 IL10 IFNG
13
Show member pathways
12.63 TNF PDCD1 IL6 IL4 IL2 IL10
14
Show member pathways
12.62 TNF IL6 IL4 IL2 IL12RB1 IL10
15
Show member pathways
12.58 TNF IL4 IL2 IFNG IFNA1
16
Show member pathways
12.56 TNF TLR3 SLAMF1 MX1 IL6 IL2
17
Show member pathways
12.4 TNF IL6 IL4 IL2 IFNG
18
Show member pathways
12.39 IL6 IL4 IL2 IL12RB1 IL10 IFNG
19
Show member pathways
12.38 TNF TLR3 IRF1 IL6 IFNG
20
Show member pathways
12.37 TNF IL6 IL4 IFNG
21
Show member pathways
12.36 TNF IL6 IL2 IL10
22 12.31 TNF IL6 IL10 IFNG IFNA1
23
Show member pathways
12.3 TNF IL4 IL10 IFNG
24
Show member pathways
12.29 TNF IRF1 IL6 IL2 IL10
25
Show member pathways
12.26 TNF TLR3 IFNG IFNA1
26
Show member pathways
12.26 TNF IRF1 IL6 IL4 IFNG
27 12.23 TNF TLR3 IL6 IFNG
28
Show member pathways
12.12 TNF MX1 IRF1 IL6 IL4 IL2
29
Show member pathways
12.11 TNF IL6 IL4 IFNG
30 12.08 TNF IL6 IL2 IL10
31 12.05 TNF IL6 IL4 IL10
32 12.05 TNF MBP IL6 IL4 IL2 IFNG
33
Show member pathways
12.04 IL4 IL2 IL12RB1 IFNG
34
Show member pathways
12.03 TNF TLR3 IL6 IL2 IL12RB1 IL10
35 11.99 TNF IL6 IL10 IFNG
36 11.93 IL6 IL2 IL12RB1 IL10 IFNG IFNA1
37 11.93 TNF SLAMF1 IL6 IL4 IL2 IL10
38 11.88 TNF IL6 IFNG
39 11.88 TNF TLR3 PDCD1 IRF1 IL4 IL2
40 11.87 IRF1 IL6 IL4 IL2 IFNG
41 11.85 TNF IRF1 IL6 IL10
42
Show member pathways
11.84 TNF IL4 IL2 IFNG
43 11.84 TNF IL4 IL2 IL12RB1 IL10 IFNG
44 11.78 TNF SLAMF1 IL6 IL2 IL10 IFNG
45
Show member pathways
11.75 TNF IL6 IL2 IFNG
46 11.73 TNF IL6 IL4 IL2 IL10 IFNG
47 11.72 IRF1 IL2 IFNG
48 11.7 TNF IL6 IL4
49
Show member pathways
11.68 TNF IL2 IFNG
50 11.65 TNF IL6 IL2 IFNG

GO Terms for Subacute Sclerosing Panencephalitis

Cellular components related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNF TLR3 IL6 IL4 IL2 IL10

Biological processes related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.2 TNF TLR3 IRF1 IL6 IL4 IL2
2 negative regulation of apoptotic process GO:0043066 10.1 PDCD1 IL6 IL4 IL2 IL10
3 innate immune response GO:0045087 10.06 TLR3 SLAMF1 MX1 IRF1 IFIH1 CD46
4 positive regulation of gene expression GO:0010628 10 TNF TLR3 IL6 IL4 IFNG CD46
5 adaptive immune response GO:0002250 9.95 SLAMF1 PDCD1 IL2 IFNG IFNA1 CD46
6 immune response GO:0006955 9.95 TNF MBP IL6 IL4 IL2 IL10
7 defense response GO:0006952 9.93 TNF TLR3 MX1 IFNA1
8 immune system process GO:0002376 9.92 TLR3 SLAMF1 PDCD1 MX1 IRF1 IL2
9 positive regulation of inflammatory response GO:0050729 9.88 TNF TLR3 IL2
10 viral entry into host cell GO:0046718 9.88 SLAMF1 MOG CD46
11 positive regulation of JNK cascade GO:0046330 9.88 TNF TLR3 SLAMF1
12 B cell differentiation GO:0030183 9.86 IL4 IL10 IFNA1
13 type I interferon signaling pathway GO:0060337 9.85 MX1 IRF1 IFNA1
14 response to glucocorticoid GO:0051384 9.85 TNF IL6 IL10
15 positive regulation of interleukin-6 production GO:0032755 9.85 TNF TLR3 IL6
16 interleukin-12-mediated signaling pathway GO:0035722 9.82 IL12RB1 IL10 IFNG
17 extrinsic apoptotic signaling pathway GO:0097191 9.81 TNF TLR3 IFNG
18 positive regulation of interferon-gamma production GO:0032729 9.81 TNF IL2 IL12RB1
19 positive regulation of T cell proliferation GO:0042102 9.8 IL6 IL4 IL2 CD46
20 negative regulation of interleukin-6 production GO:0032715 9.79 TNF SLAMF1 IL10
21 positive regulation of interleukin-6 secretion GO:2000778 9.77 TNF MBP IFIH1
22 response to virus GO:0009615 9.77 TNF TLR3 MX1 IFNG IFIH1
23 positive regulation of JAK-STAT cascade GO:0046427 9.75 TNF IL6 IL10
24 microglial cell activation GO:0001774 9.74 TNF TLR3 IFNG
25 positive regulation of neuroinflammatory response GO:0150078 9.72 TNF IL6
26 positive regulation of immunoglobulin secretion GO:0051024 9.71 IL6 IL2
27 positive regulation of regulatory T cell differentiation GO:0045591 9.71 IL2 CD46
28 negative regulation of interleukin-12 production GO:0032695 9.71 SLAMF1 IL10
29 positive regulation of interferon-beta production GO:0032728 9.71 TLR3 IRF1 IFIH1
30 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.7 MBP IL10
31 negative regulation of amyloid-beta clearance GO:1900222 9.7 TNF IFNG
32 cytokine-mediated signaling pathway GO:0019221 9.7 TNF IL6 IL4 IL2 IL12RB1 IL10
33 positive regulation of isotype switching to IgG isotypes GO:0048304 9.69 IL4 IL2
34 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.69 IL4 IL10
35 positive regulation of chemokine production GO:0032722 9.69 TNF TLR3 IL6
36 negative regulation of lipid storage GO:0010888 9.68 TNF IL6
37 endothelial cell apoptotic process GO:0072577 9.68 TNF IL10
38 necroptotic signaling pathway GO:0097527 9.67 TNF TLR3
39 positive regulation of memory T cell differentiation GO:0043382 9.67 IL12RB1 CD46
40 detection of virus GO:0009597 9.66 TLR3 IFIH1
41 negative regulation of cytokine secretion involved in immune response GO:0002740 9.66 TNF IL10
42 neuroinflammatory response GO:0150076 9.65 IL4 IFNG
43 type 2 immune response GO:0042092 9.65 IL4 IL10
44 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 TNF IL6 IL4 IL2 IFNG
45 positive regulation of chemokine biosynthetic process GO:0045080 9.63 TNF TLR3 IFNG
46 positive regulation of cellular respiration GO:1901857 9.62 IL4 IFNG
47 regulation of isotype switching GO:0045191 9.62 IL4 IL10
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IFNG
49 positive regulation of MHC class II biosynthetic process GO:0045348 9.61 IL4 IL10 IFNG
50 receptor biosynthetic process GO:0032800 9.6 TNF IL10

Molecular functions related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.16 TNF TLR3 SLAMF1 PDCD1 MYOM2 MX1
2 virus receptor activity GO:0001618 9.33 SLAMF1 MOG CD46
3 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10
4 cytokine activity GO:0005125 9.17 TNF IL6 IL4 IL2 IL10 IFNG

Sources for Subacute Sclerosing Panencephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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