SSPE
MCID: SBC001
MIFTS: 53

Subacute Sclerosing Panencephalitis (SSPE)

Categories: Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Subacute Sclerosing Panencephalitis

MalaCards integrated aliases for Subacute Sclerosing Panencephalitis:

Name: Subacute Sclerosing Panencephalitis 57 11 19 52 58 75 53 43 14 16 71 31 33
Sspe 57 19 58 75
Dawson Encephalitis 19 58 33
Immunosuppressive Measles Encephalitis 11 33
Subacute Sclerosing Leukoencephalitis 58 33
Mibe - [measles Inclusion Body Encephalitis] 33
Sspe - [subacute Sclerosing Panencephalitis] 33
Van Bogaert's Sclerosing Leukoencephalitis 11
Van Bogaert Sclerosing Leukoencephalopathy 33
Van Bogaert Sclerosing Leukoencephalitis 33
Subacute Sclerosing Leukoencephalopathy 11
Panencephalitis, Subacute Sclerosing 57
Subacute Inclusion Body Encephalitis 58
Measles Inclusion Body Encephalitis 33
Dawson Inclusion Body Encephalitis 33
Diffuse Sclerosing Encephalitis 33
Van Bogaert Leukoencephalitis 33
Bodechtel Guttman Disease 33
Van Bogaert Encephalitis 58
Van Bogaert Disease 58
Dawson Disease 19

Characteristics:


Inheritance:

Autosomal recessive 57

Prevelance:

Subacute Sclerosing Leukoencephalitis: <1/1000000 (United States) 1-9/100000 (India) 58

Age Of Onset:

Subacute Sclerosing Leukoencephalitis: All ages 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 11 DOID:8970
OMIM® 57 260470
ICD9CM 34 046.2
MeSH 43 D013344
NCIt 49 C85171
SNOMED-CT 68 84196008
ICD10 31 A81.1
ICD10 via Orphanet 32 A81.1
UMLS via Orphanet 72 C0038522
Orphanet 58 ORPHA2806
MedGen 40 C0038522
SNOMED-CT via HPO 69 45170000
ICD11 33 1098683540
UMLS 71 C0038522

Summaries for Subacute Sclerosing Panencephalitis

NINDS: 52 Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of children and young adults that affects the central nervous system (CNS). It is a slow, but persistent, viral infection caused by defective measles virus. SSPE has been reported from all parts of the world, but it is considered a rare disease in developed countries, with fewer than 10 cases per year reported in the United States. The incidence of SSPE declined by at least 90 percent in countries that have practiced widespread immunization with measles vaccine. The incidence of SSPE is still high in developing countries such as India and Eastern Europe. There is a higher incidence among males than females (male/female: 3/1). Most youngsters with SSPE have a history of measles infection at an early age, usually younger than 2 years, followed by a latent period of 6 to 8 years before neurological symptoms begin. Despite the long interval between the measles infection and the onset of SSPE, researchers think that the infection of the brain occurs soon after the primary bout with measles and progresses slowly. Why it persists and progresses still isn't clear. The initial symptoms of SSPE are subtle and include mild mental deterioration (such as memory loss) and changes in behavior (such as irritability) followed by disturbances in motor function, including uncontrollable involuntary jerking movements of the head, trunk or limbs called myoclonic jerks. Seizures may also occur. Some people may become blind. In advanced stages of the disease, individuals may lose the ability to walk, as their muscles stiffen or spasm. There is progressive deterioration to a comatose state, and then to a persistent vegetative state. Death is usually the result of fever, heart failure, or the brain's inability to continue controlling the autonomic nervous system.

MalaCards based summary: Subacute Sclerosing Panencephalitis, also known as sspe, is related to measles and chorioretinitis. An important gene associated with Subacute Sclerosing Panencephalitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. Affiliated tissues include brain, cortex and heart, and related phenotypes are infectious encephalitis and immune system

GARD: 19 Subacute sclerosing panencephalitis (SSPE) a rare condition that is caused by a measles infection acquired earlier in life. Affected people may initially experience behavioral changes, dementia, and disturbances in motor function. Ultimately, many people with SSPE succumb to fever, heart failure, or the brain's inability to continue controlling the autonomic nervous system. It is unclear why some people develop SSPE after they have seemingly recovered from the measles while others do not.

OMIM®: 57 Subacute sclerosing panencephalitis (SSPE) is a fatal neurodegenerative disease caused by persistent central nervous system infection with the measles virus (summary by Torisu et al., 2004). (260470) (Updated 08-Dec-2022)

Orphanet: 58 A chronic progressive encephalitis that develops a few years after measles infection and presents with a demyelination of the cerebral cortex.

Disease Ontology: 11 A viral infectious disease that results in infection located in brain and that has material basis in Measles virus which is immune resistant.

Wikipedia: 75 Subacute sclerosing panencephalitis (SSPE)—also known as Dawson disease—is a rare form of chronic,... more...

Related Diseases for Subacute Sclerosing Panencephalitis

Diseases related to Subacute Sclerosing Panencephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 697)
# Related Disease Score Top Affiliating Genes
1 measles 31.5 TLR3 SLAMF1 MX1 IL6 IL2 IFNA1
2 chorioretinitis 30.8 TNF IL6 IL2 IL10 IFNG
3 agnosia 30.7 TNF IL6 IL10
4 toxoplasmosis 30.5 TNF IL6 IL4 IL10 IFNG
5 papilledema 30.5 MYOM2 MOG IL6
6 croup 30.5 IL6 IFNA1 CD46
7 encephalitis 30.4 TNF TLR3 MX1 MOG IL6 IL10
8 cysticercosis 30.4 IL6 IL4 IL10
9 acute disseminated encephalomyelitis 30.3 MOG MBP IL6
10 pfeiffer syndrome 30.3 TNF SLAMF1 IL2 IL10
11 rabies 30.3 TLR3 MX1 IFNA1
12 diphtheria 30.2 TNF IL4 IL2 IFNG IFNA1
13 graft-versus-host disease 30.2 TNF IL2 IL10 IFNG
14 human immunodeficiency virus type 1 30.2 TLR3 IL2 IL10 IFNG
15 viral meningitis 30.2 TNF IL6 IFNG
16 human cytomegalovirus infection 30.1 TNF IL6 IL10
17 hypersensitivity reaction type iii disease 30.1 TNF IL6 IL10
18 meningitis 30.1 TNF IL6 IL4 IL2 IL10 IFNG
19 allergic disease 30.0 TNF IL6 IL4 IL2 IL10 IFNG
20 macular degeneration, age-related, 1 30.0 TNF TLR3 IL6 IL10 CD46
21 retinal detachment 30.0 TNF IL6 IL10 IFNG
22 bacterial pneumonia 29.9 TNF IL6 IL4 IL10 IFNG
23 cryptococcal meningitis 29.9 TNF IL6 IL4 IL2 IL10 IFNG
24 osteomyelitis 29.9 TNF IL6 IL4 IL10 IFNG
25 anterior uveitis 29.8 TNF IL6 IL2 IL10 IFNG
26 rubella 29.8 TNF TLR3 MOG IL6 IL4 IL2
27 sleep apnea 29.8 TNF IL6 IL10
28 listeriosis 29.8 TNF IL6 IL4 IL2 IL10
29 acute retrobulbar neuritis 29.8 MOG MBP
30 hydrocephalus 29.8 TNF MBP IL10 IFNG
31 encephalomalacia 29.7 TNF MBP IL6
32 mumps 29.7 TNF TLR3 MX1 IRF1 IL6 IL2
33 proteasome-associated autoinflammatory syndrome 1 29.7 TNF IL6 IL4 IL10 IFNG IFNA1
34 vasculitis 29.7 TNF IL6 IL10 IFNA2 CTLA4
35 optic neuritis 29.6 TNF MOG MBP IL6 IL10
36 herpes zoster 29.6 TLR3 PDCD1 IL2 IL10 IFNG IFNA2
37 progressive multifocal leukoencephalopathy 29.6 TNF MOG MBP IL2 CTLA4
38 cerebral palsy 29.6 TNF MBP IL6 IL4 IL10
39 conjunctivitis 29.5 TNF TLR3 IL6 IL4 IL2 IL10
40 bell's palsy 29.5 TNF TLR3 MBP IL6
41 nephrotic syndrome 29.5 TNF IL6 IL4 IL2 CTLA4
42 aseptic meningitis 29.4 TNF MOG IL6 IL10 IFNA1 CTLA4
43 neuritis 29.4 TNF MOG MBP IL6 IL4 IL10
44 neuromyelitis optica 29.3 MOG MBP IL6 IL4 IFNA1
45 severe combined immunodeficiency 29.3 TNF IL6 IL4 IL2 IL10 IFNG
46 combined immunodeficiency 29.3 TNF IL6 IL4 IL2 IL10 IFNG
47 bronchiolitis 29.3 TNF TLR3 IL6 IL4 IL2 IL10
48 uveitis 29.2 TNF IL6 IL4 IL2 IL10 IFNG
49 poliomyelitis 29.2 TNF TLR3 IL6 IL2 IL10 IFNG
50 amyotrophic lateral sclerosis 1 29.1 TNF MOG MBP IL6 IL4 IL10

Graphical network of the top 20 diseases related to Subacute Sclerosing Panencephalitis:



Diseases related to Subacute Sclerosing Panencephalitis

Symptoms & Phenotypes for Subacute Sclerosing Panencephalitis

Human phenotypes related to Subacute Sclerosing Panencephalitis:

30
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 infectious encephalitis 30 HP:0002383

Symptoms via clinical synopsis from OMIM®:

57 (Updated 08-Dec-2022)
Neuro:
subacute sclerosing panencephalitis

Clinical features from OMIM®:

260470 (Updated 08-Dec-2022)

GenomeRNAi Phenotypes related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 CD46 CTLA4 IFIH1 IFNA1 IFNA2 IFNG
2 no effect GR00402-S-2 10.14 CD46 CTLA4 IFIH1 IFNA1 IFNA2 IFNG

MGI Mouse Phenotypes related to Subacute Sclerosing Panencephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.28 CTLA4 IFIH1 IFNA1 IFNA2 IFNG IL10
2 homeostasis/metabolism MP:0005376 10.25 CTLA4 IFIH1 IFNG IL10 IL12RB1 IL2
3 liver/biliary system MP:0005370 10.09 CTLA4 IFIH1 IFNG IL10 IL2 IL4
4 endocrine/exocrine gland MP:0005379 10.07 CTLA4 IFNG IL10 IL2 IL4 IL6
5 neoplasm MP:0002006 10.06 IFNG IL10 IL2 IL6 IRF1 PDCD1
6 respiratory system MP:0005388 10 CTLA4 IFNA1 IFNA2 IFNG IL10 IL2
7 vision/eye MP:0005391 9.97 CD46 IFNG IL10 IL12RB1 IL2 IL4
8 hematopoietic system MP:0005397 9.91 CTLA4 IFIH1 IFNA1 IFNA2 IFNG IL10
9 integument MP:0010771 9.32 CTLA4 IFIH1 IFNG IL10 IL12RB1 IL4

Drugs & Therapeutics for Subacute Sclerosing Panencephalitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Measles Subacute Sclerosing Panencephalitis (SSPE)and the Role of Ketogenic Diet, A Prospective Cohort Study Not yet recruiting NCT05152771

Search NIH Clinical Center for Subacute Sclerosing Panencephalitis

Cochrane evidence based reviews: subacute sclerosing panencephalitis

Genetic Tests for Subacute Sclerosing Panencephalitis

Anatomical Context for Subacute Sclerosing Panencephalitis

Organs/tissues related to Subacute Sclerosing Panencephalitis:

FMA: Brain
MalaCards : Brain, Cortex, Heart, Dorsal Root Ganglion, B Cells, Lymph Node, T Cells

Publications for Subacute Sclerosing Panencephalitis

Articles related to Subacute Sclerosing Panencephalitis:

(show top 50) (show all 2458)
# Title Authors PMID Year
1
Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. 53 62 57
14872030 2004
2
Contribution of the interleukin 4 gene to susceptibility to subacute sclerosing panencephalitis. 62 57
12020266 2002
3
Subacute sclerosing panencephalitis in a brother and sister. Therapeutic trial of fibroblast interferon. 62 57
6178588 1982
4
Analysis of MxA, IL-4, and IRF-1 genes in Filipino patients with subacute sclerosing panencephalitis. 53 62
17177148 2006
5
Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. 53 62
16034142 2005
6
Long-term follow-up of a patient with subacute sclerosing panencephalitis successfully treated with intrathecal interferon alpha. 53 62
15862195 2005
7
Expression of the interferon-alpha/beta-inducible MxA protein in brain lesions of subacute sclerosing panencephalitis. 53 62
15337611 2004
8
An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis. 53 62
11950898 2002
9
Analysis of measles virus binding sites of the CD46 gene in patients with subacute sclerosing panencephalitis. 53 62
10751138 2000
10
[Recent advances in the treatment the nervous system disorders with interferon-alpha]. 53 62
10652752 1999
11
Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia. 53 62
10378377 1999
12
The cooperative effect of interferon-alpha and ribavirin on subacute sclerosing panencephalitis (SSPE) virus infections, in vitro and in vivo. 53 62
9497070 1998
13
Absence of measles virus receptor (CD46) in lesions of subacute sclerosing panencephalitis brains. 53 62
9386776 1997
14
Receptor usage and differential downregulation of CD46 by measles virus wild-type and vaccine strains. 53 62
7732009 1995
15
[A case of subacute sclerosing panencephalitis treated with intraventricular interferon--the side effects of interferon-alpha to the central nervous system]. 53 62
8156718 1994
16
Intraventricular interferon and oral inosiplex in the treatment of subacute sclerosing panencephalitis. 53 62
1372397 1992
17
Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha. 53 62
1996885 1991
18
A Re-emergence of Subacute Sclerosing Panencephalitis in the United Kingdom. 62
36410008 2023
19
Cavitating Leukoencephalopathy in Subacute Sclerosing Panencephalitis. 62
36193957 2022
20
Place of magistral preparations in order to continue the treatment if the drug is commercially stopped worldwide? A case report of 10-years-old child with subacute sclerosing panencephalitis (SSPE) requiring inosiplex. 62
36458570 2022
21
Preliminary seroprevalence study of neurotropic virus antibodies in Nodding syndrome. 62
36133256 2022
22
The EEG Features of Four Cases of Subacute Sclerosing Panencephalitis in North China : SSPE EEG Features. 62
36341690 2022
23
Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. 62
36351933 2022
24
A multicentre observational study of the prevalence, management, and outcomes of subsegmental pulmonary embolism. 62
36342637 2022
25
Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies. 62
35373453 2022
26
Uncommon histopathological features of cytomegalovirus encephalitis and measles inclusion body encephalitis on autopsy in two patients with primary immunodeficiency. 62
36278299 2022
27
Spectral Domain Optical Coherence Tomography Findings of Subacute Sclerosing Panencephalitis Presenting with Macular Necrotizing Retinitis: A Case Report. 62
36122304 2022
28
Measles Virus and Subacute Sclerosing Panencephalitis. 62
36125141 2022
29
Diagnostic reference value of antibody levels measured using enzyme immunoassay for subacute sclerosing panencephalitis. 62
35766430 2022
30
Cortical activation and motor body representations in a patient with subacute sclerosing panencephalitis. 62
35714969 2022
31
Teaching Video NeuroImage: Slow Axial Myoclonus in Subacute Sclerosing Panencephalitis. 62
36240086 2022
32
A Comprehensive Investigation of the Current Subacute Sclerosing Panencephalitis (SSPE) Treatment Options to Improve Patient Quality of Life. 62
36171840 2022
33
Upregulation of viral RNA polymerase activity promotes adaptation of SSPE virus to neuronal cells. 62
35679629 2022
34
Relapsing-remitting subacute sclerosing panencephalitis: A case report. 62
35257393 2022
35
Single versus multiple and incidental versus symptomatic subsegmental pulmonary embolism: clinical characteristics and outcome. 62
34993715 2022
36
Oligoclonal bands: a laboratory diagnosis of subacute sclerosing panencephalitis (SSPE). 62
35797306 2022
37
[Measles subacute sclerosing panencephalitis (SSPE): A still present and still mysterious fatal disease. History, Diagnosis and Assumptions]. 62
35766853 2022
38
Rapidly progressive dementia with generalized myoclonus in an adult: Do not forget subacute sclerosing panencephalitis. 62
35672127 2022
39
Structural and Functional Analysis of DndE Involved in DNA Phosphorothioation in the Haloalkaliphilic Archaea Natronorubrum bangense JCM10635. 62
35420474 2022
40
Corrigendum to "Measles Sclerosing Subacute PanEncephalitis (SSPE), an intriguing and ever-present disease: Data, Assumptions and new Perspectives" [Rev. Neurol. 177 (2021) 1059-68]. 62
35610097 2022
41
A Mouse-Based Method to Monitor Wheat Allergens in Novel Wheat Lines and Varieties Created by Crossbreeding: Proof-of-Concept Using Durum and A. tauschii Wheats. 62
35742949 2022
42
Subacute Sclerosing Panencephalitis Masquerading as Schizophrenia: An Example of Diagnostic Overshadowing in Neuropsychiatry. 62
35561325 2022
43
Case Report: Focal Myoclonus with a Striatal Lesion as a Presentation of Subacute Sclerosing Panencephalitis. 62
35533695 2022
44
Subsegmental pulmonary embolism and anticoagulant therapy: the impact of clinical context. 62
35499105 2022
45
Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study. 62
35262436 2022
46
Subacute Sclerosing Panencephalitis (SSPE): Experience from a Tertiary-Care Pediatric Center. 62
35694059 2022
47
Macular Necrotizing Retinitis as a Presenting Feature of Atypical Fulminant SSPE: A Case Report. 62
35404754 2022
48
Comparative study on molecular epidemiology of measles H1 outbreak and sporadic cases in Shandong Province, 2013-2019. 62
35421927 2022
49
Progressive Vision Loss and Cognitive Decline as Presenting Manifestation of Adult Onset Subacute Sclerosing Panencephalitis. 62
35483071 2022
50
Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination. 62
35458463 2022

Variations for Subacute Sclerosing Panencephalitis

Expression for Subacute Sclerosing Panencephalitis

Search GEO for disease gene expression data for Subacute Sclerosing Panencephalitis.

Pathways for Subacute Sclerosing Panencephalitis

Pathways related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.97 CD46 CTLA4 IFIH1 IFNA1 IFNA2 IFNG
2
Show member pathways
13.67 IFNA1 IFNA2 IFNG IL10 IL12RB1 IL2
3
Show member pathways
13.59 IFNA1 IFNA2 IFNG IL10 IL12RB1 IL2
4
Show member pathways
13.43 TNF TLR3 IL6 IL4 IL2 IL12RB1
5
Show member pathways
13.37 TNF MX1 IRF1 IL6 IL4 IL2
6
Show member pathways
12.92 TNF TLR3 SLAMF1 MX1 IL6 IL2
7
Show member pathways
12.66 TNF IL6 IL2 IL12RB1 IL10 IFNG
8
Show member pathways
12.59 MX1 IRF1 IFNG IFNA2 IFNA1
9
Show member pathways
12.57 TNF TLR3 IL6 IFNA2 IFNA1
10
Show member pathways
12.57 TNF MX1 IRF1 IL6 IL4 IL2
11
Show member pathways
12.52 TLR3 IFNG IFNA2 IFNA1 IFIH1
12
Show member pathways
12.47 TNF IRF1 IL6 IL4 IFNG
13
Show member pathways
12.44 TLR3 IL6 IFNA2 IFNA1
14
Show member pathways
12.38 TNF TLR3 IRF1 IL6 IFNG
15
Show member pathways
12.25 TNF IL4 IL2 IFNG
16 12.24 TNF TLR3 IL6 IFNG
17
Show member pathways
12.24 CTLA4 IFNG IL10 IL12RB1 IL2 IL4
18 12.18 TNF IL6 IL4 IL10 IFNG
19 12.1 TNF MBP IL6 IL4 IL2 IFNG
20
Show member pathways
12.04 IFNG IL12RB1 IL2 IL4
21 12.02 TNF IL6 IL4 IL10
22
Show member pathways
12.02 TNF TLR3 IL6 IL2 IL12RB1 IL10
23 11.98 TNF IL4 IL2 IL10 IFNG CTLA4
24
Show member pathways
11.97 TLR3 IL6 IL4 IL12RB1 IFNG
25
Show member pathways
11.95 TLR3 MX1 IFNA2 IFIH1
26 11.93 IL6 IFNG IFNA2 IFNA1
27 11.92 TNF TLR3 PDCD1 IRF1 IL4 IL2
28 11.9 TNF IL4 IL2 IL12RB1 IL10 IFNG
29 11.89 IRF1 IL6 IL4 IL2 IFNG
30 11.87 IFNG IL10 IL2 IL6 TLR3
31 11.85 TNF SLAMF1 IL6 IL2 IL10 IFNG
32 11.83 IL6 IL4 IL2 IL10 IFNG
33 11.81 IFNG IL2 IL4 IL6
34
Show member pathways
11.81 TNF IL4 IL2 IFNG CTLA4
35 11.8 TNF PDCD1 IL6 IL4 IL2 IL10
36 11.79 IFNA2 IL6 TNF
37
Show member pathways
11.76 TNF IL6 IL2 IFNG
38 11.75 TNF IRF1 IL6 IL10
39 11.74 IRF1 IL2 IFNG
40 11.71 TNF IL6 IL4
41 11.7 TNF IL6 IL10
42 11.65 TNF IL6 IFNG IFNA2
43 11.65 IFNG IL10 IL12RB1 IL2 IL4 TNF
44 11.64 IL6 IL2 IFNG
45 11.62 TNF SLAMF1 IL6 IL4 IL2 IL10
46 11.61 TNF MX1 IL10
47 11.6 IL4 IL2 IL10 IFNG
48 11.58 CTLA4 IL4 PDCD1
49 11.57 TNF IL6 IL10
50 11.55 TNF IL6 IFNG

GO Terms for Subacute Sclerosing Panencephalitis

Cellular components related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.4 TNF SLAMF1 PDCD1 MOG IL12RB1 CTLA4

Biological processes related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.38 CD46 CTLA4 IFNA1 IFNA2 IFNG IL2
2 positive regulation of inflammatory response GO:0050729 10.24 TNF TLR3 IL2 IFNG
3 positive regulation of tumor necrosis factor production GO:0032760 10.23 TLR3 IL6 IFNG IFIH1
4 immune response GO:0006955 10.22 CTLA4 IFNG IL10 IL2 IL4 IL6
5 B cell differentiation GO:0030183 10.19 IL4 IL10 IFNA2 IFNA1
6 response to virus GO:0009615 10.18 TNF TLR3 MX1 IFNG IFIH1
7 regulation of insulin secretion GO:0050796 10.17 TNF IL6 IFNG
8 B cell proliferation GO:0042100 10.16 IL10 IFNA2 IFNA1
9 response to activity GO:0014823 10.16 TNF IL6 IL10
10 positive regulation of type II interferon production GO:0032729 10.16 TNF TLR3 SLAMF1 IL2 IL12RB1
11 negative regulation of viral genome replication GO:0045071 10.15 TNF MX1 IFIH1
12 positive regulation of interleukin-12 production GO:0032735 10.15 IFNG IRF1 TLR3
13 positive regulation of interleukin-6 production GO:0032755 10.15 TNF TLR3 MBP IL6 IFNG IFIH1
14 positive regulation of interleukin-10 production GO:0032733 10.14 IL6 IL4 CD46
15 positive regulation of interferon-beta production GO:0032728 10.13 TLR3 IRF1 IFIH1
16 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.13 TNF IL6 IL10
17 response to exogenous dsRNA GO:0043330 10.12 TLR3 IFNA2 IFNA1
18 positive regulation of chemokine production GO:0032722 10.11 IFNG IL6 TLR3 TNF
19 liver regeneration GO:0097421 10.1 TNF IL6 IL10
20 positive regulation of cytokine production GO:0001819 10.1 TNF TLR3 IL10 IFNG
21 positive regulation of T cell proliferation GO:0042102 10.09 CD46 IL2 IL4 IL6
22 positive regulation of activated T cell proliferation GO:0042104 10.08 IL12RB1 IL2 SLAMF1
23 positive regulation of immunoglobulin production GO:0002639 10.08 IL6 IL2 IL10
24 regulation of immune response GO:0050776 10.07 PDCD1 IRF1 IL4
25 defense response to virus GO:0051607 10.06 TLR3 MX1 IRF1 IL6 IFNG IFNA2
26 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 10.04 IFNG IFNA2 IFNA1
27 microglial cell activation GO:0001774 10.03 TNF TLR3 IL4 IFNG
28 cellular response to virus GO:0098586 10.03 IFIH1 IFNA1 IFNA2 IFNG IL6 TLR3
29 immune system process GO:0002376 10.02 TLR3 SLAMF1 PDCD1 MX1 IRF1 IL2
30 positive regulation of MHC class II biosynthetic process GO:0045348 10.01 IL4 IL10 IFNG
31 negative regulation of regulatory T cell differentiation GO:0045590 9.98 IRF1 CTLA4
32 detection of virus GO:0009597 9.98 TLR3 IFIH1
33 positive regulation of mononuclear cell migration GO:0071677 9.97 TNF IL4
34 defense response GO:0006952 9.97 TNF TLR3 MX1 IFNA2 IFNA1
35 negative regulation of cytokine production involved in immune response GO:0002719 9.96 TNF IL10
36 regulation of isotype switching GO:0045191 9.94 IL10 IL4
37 positive regulation of plasma cell differentiation GO:1900100 9.92 IL2 IL10
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.92 TNF IFNG
39 positive regulation of nitrogen compound metabolic process GO:0051173 9.91 TNF IFNG
40 chronic inflammatory response to antigenic stimulus GO:0002439 9.88 IL10 TNF
41 positive regulation of vitamin D biosynthetic process GO:0060557 9.88 IFNG TNF
42 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 IFNA2 IFNG IL2 IL4 IL6 TNF
43 humoral immune response GO:0006959 9.4 TNF PDCD1 IL6 IFNG IFNA2 IFNA1

Molecular functions related to Subacute Sclerosing Panencephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.53 TNF IL6 IL4 IL2 IL10 IFNG
2 cytokine receptor binding GO:0005126 9.13 IL4 IFNA2 IFNA1

Sources for Subacute Sclerosing Panencephalitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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