MCID: SBC007
MIFTS: 46

Subacute Thyroiditis

Categories: Endocrine diseases, Infectious diseases

Aliases & Classifications for Subacute Thyroiditis

MalaCards integrated aliases for Subacute Thyroiditis:

Name: Subacute Thyroiditis 12 36 15 17 71 32
Subacute Granulomatous Thyroiditis 12
De Quervain's Thyroiditis 12
Granulomatous Thyroiditis 12
Giant-Cell Thyroiditis 12
Thyroiditis, Subacute 43
Thyroiditis Subacute 54

Classifications:



External Ids:

Disease Ontology 12 DOID:7165
KEGG 36 H01647
ICD9CM 34 245.1
MeSH 43 D013968
SNOMED-CT 67 38727009
ICD10 32 E06.1
UMLS 71 C0040149

Summaries for Subacute Thyroiditis

KEGG : 36 Subacute thyroiditis (SAT), also called subacute granulomatous or de Quervain thyroiditis, is a spontaneously remitting, painful, inflammatory disease of the thyroid gland, which is considered the most common cause of painful thyroiditis. It is an uncommon but important cause of fever of unknown origin (FUO). SAT is often preceded by an upper respiratory tract infection and occurs concurrently with outbreaks of viral diseases (mumps, measles, influenza). However, the exact etiology is unknown. Clinically, it presents with acute onset of pain in the thyroid region. The pain may be exacerbated by turning the head or swallowing, and may radiate to the jaw, ear or chest. Common initial clinical features include low-grade fever, fatigue, and mild thyrotoxic manifestations. The physical examination, an elevated erythrocyte sedimentation rate, an elevated thyroglobulin level, and a depressed radioactive iodine uptake confirm the diagnosis. Therapy with antithyroid drugs is not indicated in patients with SAT because this disorder is caused by the release of preformed thyroid hormone rather than synthesis of new T3 and T4. Therapy with beta blockers may be indicated for the symptomatic treatment of thyrotoxicosis. Nonsteroidal anti-inflammatory drugs are generally effective in reducing thyroid pain in patients with mild cases. Patients with more severe disease require a tapering dosage of prednisone given over two to four weeks.

MalaCards based summary : Subacute Thyroiditis, also known as subacute granulomatous thyroiditis, is related to suppurative thyroiditis and thyroid lymphoma. An important gene associated with Subacute Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are T cell receptor signaling pathway and Th17 cell differentiation. The drugs Celecoxib and Xylometazoline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and heart, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 74 Subacute thyroiditis is a form of thyroiditis that can be a cause of both thyrotoxicosis and... more...

Related Diseases for Subacute Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Subacute Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 581)
# Related Disease Score Top Affiliating Genes
1 suppurative thyroiditis 30.9 TG CRP
2 thyroid lymphoma 30.3 TNF TG
3 thyroiditis 30.3 TSHR TPO TNF TG SERPINA7 IL6
4 vasculitis 30.2 TNF IL6 CRP
5 graves' disease 30.1 TSHR TPO TG SERPINA7
6 nocardiosis 30.1 TNF CRP
7 temporal arteritis 30.1 TNF IL6 CRP
8 transverse myelitis 30.0 TNF IL6
9 thyroid carcinoma 30.0 TSHR TPO TG
10 chlamydia pneumonia 29.9 TNF IL6 CRP
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.9 TSHR TPO TG
12 chickenpox 29.9 TNF IL6 CRP
13 endocarditis 29.9 TNF IL6 CRP
14 graves disease 1 29.9 TSHR TPO TG SHBG SERPINA7
15 purpura 29.9 TNF IL6 CRP
16 viral hepatitis 29.8 TNF IL6 CRP
17 sarcoidosis 1 29.7 TNF IL1B CRP
18 thyroid gland anaplastic carcinoma 29.6 TPO TG
19 pharyngitis 29.6 TNF IL6 IL1B CRP
20 cytomegalovirus infection 29.6 TNF IL6 IL1B
21 thrombocytosis 29.5 IL6 IL1B CRP
22 glucose intolerance 29.5 TNF SHBG IL6 CRP
23 q fever 29.5 TNF IL6 IL1B
24 papillary carcinoma 29.5 TSHR TPO TG
25 myocarditis 29.5 TNF IL6 IL1B
26 tonsillitis 29.5 TNF IL6 IL1B
27 duodenal ulcer 29.5 TNF IL6 IL1B
28 chlamydia 29.5 TNF IL6 IL1B CRP
29 juvenile rheumatoid arthritis 29.5 TNF IL6 IL1B CRP
30 exanthem 29.4 VEGFA TNF IL6 CRP
31 thyroid gland disease 29.4 TSHR TPO TG SERPINA7
32 brucellosis 29.4 TNF TGFB1 IL6 CRP
33 myeloma, multiple 29.3 VEGFA TNF IL6 CRP
34 adult-onset still's disease 29.3 TNF IL6 IL1B CRP
35 typhoid fever 29.2 TNF IL6 IL1B CRP
36 iodine hypothyroidism 29.2 TSHR TPO TG
37 otitis media 29.2 TNF IL6 IL1B CRP
38 hyperthyroidism 29.2 TSHR TPO TG SHBG SERPINA7 SERPINA6
39 ulcerative colitis 29.2 TNF IL6 IL1B CRP
40 hyperthyroxinemia 29.2 TSHR TPO SERPINA7
41 subacute lymphocytic thyroiditis 29.1 TSHR TPO TG CRP
42 psoriatic arthritis 29.0 VEGFA TNF IL6 IL1B CRP
43 thyroid crisis 28.9 TSHR TPO TG SERPINA7
44 goiter 28.9 VEGFA TSHR TPO TG SHBG SERPINA7
45 diarrhea 28.9 TNF TGFB1 IL6 IL1B
46 plummer's disease 28.9 TSHR TPO TG SHBG
47 vascular disease 28.9 VEGFA TNF TGFB1 IL6 CRP
48 connective tissue disease 28.7 VEGFA TNF IL6 IL1B CRP
49 laryngitis 28.7 TNF TGFB1 IL6 IL1B CRP
50 hypothyroidism 28.6 VEGFA TSHR TPO TNF TG SHBG

Graphical network of the top 20 diseases related to Subacute Thyroiditis:



Diseases related to Subacute Thyroiditis

Symptoms & Phenotypes for Subacute Thyroiditis

MGI Mouse Phenotypes related to Subacute Thyroiditis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.96 CRP IL1B IL6 SERPINA6 TG TGFB1
2 immune system MP:0005387 9.85 CRP IL1B IL6 SERPINA6 TG TGFB1
3 neoplasm MP:0002006 9.43 IL1B IL6 TGFB1 TNF TSHR VEGFA
4 skeleton MP:0005390 9.23 IL1B IL6 TG TGFB1 TNF TPO

Drugs & Therapeutics for Subacute Thyroiditis

Drugs for Subacute Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4 Anti-Inflammatory Agents Phase 4
5 Hormone Antagonists Phase 4
6 Hormones Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 glucocorticoids Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
2 Clinical Diagnostic Evaluation of Thyroid Nodules Not yet recruiting NCT03884140

Search NIH Clinical Center for Subacute Thyroiditis

Cochrane evidence based reviews: thyroiditis, subacute

Genetic Tests for Subacute Thyroiditis

Anatomical Context for Subacute Thyroiditis

MalaCards organs/tissues related to Subacute Thyroiditis:

40
Thyroid, Bone, Heart, Liver, Lung, T Cells, Pituitary

Publications for Subacute Thyroiditis

Articles related to Subacute Thyroiditis:

(show top 50) (show all 1008)
# Title Authors PMID Year
1
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 54 61
17887926 2007
2
"Thyrotoxic psychosis" associated with subacute thyroiditis. 54 61
17713314 2007
3
Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis. 54 61
11506478 2001
4
[Serum thyroglobulin measurement and its clinical significance]. 54 61
10483254 1999
5
Identification of thyroid hormone residues on serum thyroglobulin: a clue to the source of circulating thyroglobulin in thyroid diseases. 54 61
10229914 1999
6
Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases. 54 61
10347809 1999
7
[Correlation of ultrasound and radioisotope studies in subacute de Quervain thyroiditis]. 54 61
10518399 1999
8
Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and Western blot. 54 61
9849814 1998
9
[Diagnostic value of thyroid antibodies]. 54 61
8966023 1996
10
Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid. 54 61
8636270 1996
11
The detection of serum IgM to thyroglobulin in subacute thyroiditis suggests a protective role of IgM in thyroid autoimmunity. 61
31996918 2020
12
Elevated phosphatidylserine-specific phospholipase A1 level in hyperthyroidism. 61
31978406 2020
13
Time-Lag Between Symptom Onset and Diagnosis of Subacute Thyroiditis - How to Avoid the Delay of Diagnosis and Unnecessary Overuse of Antibiotics. 61
31770810 2020
14
Characteristics of Chinese patients with primary Sjögren's syndrome: preliminary report of a multi-centre registration study. 61
31793380 2020
15
The prognostic and diagnostic use of hematological parameters in subacute thyroiditis patients. 61
31865557 2019
16
Efficacy and safety of ultrasound-guided intrathyroidal injection of glucocorticoids versus routine oral administration of glucocorticoids for subacute thyroiditis: Protocol of systematic review and meta-analysis. 61
31876758 2019
17
A Case of Subacute Thyroiditis Associated with Erythrovirus B19 Infection. 61
31862327 2019
18
An Evaluation of the Results of the Steroid and Non-steroidal Anti-inflammatory Drug Treatments in Subacute Thyroiditis in relation to Persistent Hypothyroidism and Recurrence. 61
31729433 2019
19
Acute suppurative thyroiditis with thyroid metastasis from esophageal cancer. 61
31681975 2019
20
Moderate Frequency of Anti-Thyroglobulin Antibodies in the Early Phase of Subacute Thyroiditis. 61
31768338 2019
21
Long-term Outcome of Subacute Thyroiditis. 61
31546269 2019
22
Female Patient with Simultaneous Occurrence of Subacute Thyroiditis and Focal Autonomy. 61
31412373 2019
23
Thyroid primary and metastatic malignant tumours of poor prognosis may mimic subacute thyroiditis - time to change the diagnostic criteria: case reports and a review of the literature. 61
31387553 2019
24
Plasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis? 61
31602365 2019
25
Subacute thyroiditis by dasatinib. 61
31351661 2019
26
Putting All the Pieces Together: Clinical, Macroscopic and Microscopic Characteristics of Subacute Thyroiditis. 61
29427032 2019
27
Life-threatening Misdiagnosis of Bulbar Type Onset Myasthenia Gravis as a Subacute Thyroiditis. 61
31260558 2019
28
A Case of Dynamic Evolution of Thyrotoxicosis on Follow-up. 61
31142404 2019
29
SUBACUTE THYROIDITIS IN A CHILD. 61
31967030 2019
30
Serum autotaxin levels are associated with Graves' disease. 61
30814442 2019
31
Metabolomics and Their Ability to Distinguish Thyroid Disorders: A Retrospective Pilot Study. 61
30791054 2019
32
Treatment of lidocaine on subacute thyroiditis via restraining inflammatory factor expression and inhibiting pyroptosis pathway. 61
30963625 2019
33
The Risk of Recurrence of Subacute Thyroiditis Is HLA-Dependent. 61
30832406 2019
34
Clinical characteristics of subacute thyroiditis is different than it used to be - current state based on 15 years own material. 61
30860680 2019
35
Initial treatment combined with Prunella vulgaris reduced prednisolone consumption for patients with subacute thyroiditis. 61
30906749 2019
36
Kyphoscoliosis with Klippel-Trenaunay syndrome: a case report and literature review. 61
30611239 2019
37
Thyroid Diagnosis from SPECT Images Using Convolutional Neural Network with Optimization. 61
30766599 2019
38
Sonographic Pattern of Subacute Thyroiditis Is HLA-Dependent. 61
30728805 2019
39
Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects. 61
30936776 2019
40
[General practitioner management of subacute thyroiditis]. 61
30318408 2019
41
Clostridium difficile colitis in the setting of subacute thyroiditis: the chicken or the egg. 61
30567894 2018
42
Erratum: Occurrence of Subacute Thyroiditis following Influenza Vaccination. 61
30766840 2018
43
Sustained ventricular tachycardia caused by subacute thyroiditis. 61
30182396 2018
44
Occurrence of Subacute Thyroiditis following Influenza Vaccination. 61
30294587 2018
45
Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report. 61
29315620 2018
46
Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients. 61
30210035 2018
47
[Challenges in the management of amiodarone-induced thyrotoxicosis]. 61
30274916 2018
48
TNF-alpha is upregulated in subacute thyroiditis and stimulates expression of miR-155-5p in thyroid follicle cells. 61
30399324 2018
49
Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor-α inhibitor. 61
29460956 2018
50
Subacute Thyroiditis: A Rare Complication of Dengue. 61
31331159 2018

Variations for Subacute Thyroiditis

Expression for Subacute Thyroiditis

Search GEO for disease gene expression data for Subacute Thyroiditis.

Pathways for Subacute Thyroiditis

Pathways related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 TNF TGFB1 IL6 IL1B
2
Show member pathways
12.5 TNF TGFB1 IL6 IL1B
3
Show member pathways
12.28 TNF IL6 IL1B CRP
4
Show member pathways
12.17 TNF TGFB1 IL6 IL1B
5 12.17 TNF TGFB1 IL6 IL1B
6 12.12 VEGFA TNF TGFB1 IL6
7 12.11 VEGFA TNF IL6 IL1B
8 12.01 VEGFA TNF IL1B
9 11.99 VEGFA TGFB1 IL6
10 11.99 TNF TGFB1 IL6
11 11.97 TNF TGFB1 IL1B
12
Show member pathways
11.97 TNF TGFB1 IL6 IL1B
13
Show member pathways
11.97 VEGFA TSHR TPO TNF TGFB1 TG
14
Show member pathways
11.96 TNF IL6 IL1B
15 11.93 TNF IL6 IL1B
16 11.93 TNF TGFB1 IL6 IL1B
17 11.9 TNF IL6 IL1B
18 11.86 TGFB1 IL6 IL1B
19 11.85 TNF TGFB1 IL6 IL1B
20 11.83 TNF IL6 IL1B
21 11.78 VEGFA TNF TGFB1 IL6 IL1B
22 11.71 TNF IL6 IL1B
23 11.68 TNF TGFB1 IL6 IL1B
24 11.65 TNF TGFB1 IL6 IL1B
25
Show member pathways
11.58 VEGFA TNF IL6 IL1B
26 11.57 TNF IL6 IL1B
27 11.56 TNF TGFB1 IL6 IL1B
28 11.55 VEGFA TNF TGFB1 IL6 IL1B
29 11.52 VEGFA TGFB1 IL6
30 11.5 TNF IL6 IL1B
31 11.49 TPO IL6 IL1B
32 11.48 TNF TGFB1 IL1B
33 11.44 TNF IL6 IL1B
34 11.43 TNF TGFB1 IL6 IL1B
35 11.39 VEGFA TPO TGFB1 IL6
36 11.34 TNF IL6 IL1B
37 11.32 VEGFA TNF TGFB1 IL6 IL1B
38 11.3 TNF IL6 IL1B
39 11.26 TNF IL6 IL1B
40 11.23 TNF IL6 IL1B
41 11.02 TNF TGFB1 IL6 IL1B
42 10.98 TNF IL6 CRP
43 10.89 TNF IL1B
44 10.82 TNF TGFB1
45 10.32 TSHR TPO TG

GO Terms for Subacute Thyroiditis

Cellular components related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 VEGFA TPO TNF TGFB1 SERPINA7 SERPINA6
2 cell surface GO:0009986 9.55 VEGFA TSHR TPO TNF TGFB1
3 secretory granule GO:0030141 9.43 VEGFA TGFB1 IL1B
4 extracellular region GO:0005576 9.32 VEGFA TNF TGFB1 TG SHBG SERPINA7

Biological processes related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.02 VEGFA TSHR TGFB1 IL6 IL1B
2 inflammatory response GO:0006954 9.89 TNF TGFB1 IL6 IL1B CRP
3 positive regulation of protein phosphorylation GO:0001934 9.86 VEGFA TNF TGFB1 IL1B
4 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNF IL6 IL1B
5 defense response to Gram-positive bacterium GO:0050830 9.83 TNF IL6 CRP
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 VEGFA TGFB1 IL6
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 VEGFA TNF IL6
8 cellular response to organic cyclic compound GO:0071407 9.8 TNF TGFB1 IL1B
9 positive regulation of MAP kinase activity GO:0043406 9.79 VEGFA TNF TGFB1
10 positive regulation of interleukin-6 production GO:0032755 9.78 TNF IL6 IL1B
11 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 TNF TGFB1 IL6 IL1B
12 cytokine-mediated signaling pathway GO:0019221 9.77 VEGFA TNF TGFB1 IL6 IL1B
13 negative regulation of fat cell differentiation GO:0045599 9.76 TNF TGFB1 IL6
14 positive regulation of cell division GO:0051781 9.74 VEGFA TGFB1 IL1B
15 positive regulation of epithelial to mesenchymal transition GO:0010718 9.72 TGFB1 IL6 IL1B
16 positive regulation of protein complex assembly GO:0031334 9.71 VEGFA TNF TGFB1
17 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.69 VEGFA TGFB1
18 protein kinase B signaling GO:0043491 9.69 TNF TGFB1 IL1B
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 TNF IL1B
20 positive regulation of superoxide anion generation GO:0032930 9.68 TGFB1 CRP
21 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.68 VEGFA IL1B
22 negative regulation of lipid catabolic process GO:0050995 9.68 TNF IL1B
23 astrocyte activation GO:0048143 9.67 TNF IL1B
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 TNF IL1B
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 TNF IL1B
26 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.66 TNF IL1B
27 positive regulation of vascular permeability GO:0043117 9.65 VEGFA TGFB1
28 hormone biosynthetic process GO:0042446 9.65 TPO TG
29 positive regulation of chemokine biosynthetic process GO:0045080 9.64 TNF IL1B
30 regulation of establishment of endothelial barrier GO:1903140 9.63 TNF IL1B
31 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 TNF TGFB1 IL1B
32 positive regulation of gene expression GO:0010628 9.63 VEGFA TNF TGFB1 IL6 IL1B CRP
33 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 TGFB1 IL6 IL1B
34 positive regulation of mononuclear cell migration GO:0071677 9.6 TNF TGFB1
35 positive regulation of fever generation GO:0031622 9.59 TNF IL1B
36 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
37 negative regulation of neurogenesis GO:0050768 9.58 TNF IL6 IL1B
38 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.56 VEGFA TNF TGFB1 IL6
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.52 TNF IL1B
40 positive regulation of glial cell proliferation GO:0060252 9.5 TNF IL6 IL1B
41 positive regulation of neuroinflammatory response GO:0150078 9.13 TNF IL6 IL1B
42 negative regulation of lipid storage GO:0010888 8.8 TNF IL6 CRP

Molecular functions related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 VEGFA TNF TGFB1 IL6 IL1B

Sources for Subacute Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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