MCID: SBC007
MIFTS: 40

Subacute Thyroiditis

Categories: Endocrine diseases, Infectious diseases

Aliases & Classifications for Subacute Thyroiditis

MalaCards integrated aliases for Subacute Thyroiditis:

Name: Subacute Thyroiditis 12 37 15 17 72 33
Subacute Granulomatous Thyroiditis 12
De Quervain's Thyroiditis 12
Granulomatous Thyroiditis 12
Giant-Cell Thyroiditis 12
Thyroiditis, Subacute 44
Thyroiditis Subacute 55

Classifications:



External Ids:

Disease Ontology 12 DOID:7165
KEGG 37 H01647
ICD9CM 35 245.1
MeSH 44 D013968
SNOMED-CT 68 38727009
ICD10 33 E06.1
UMLS 72 C0040149

Summaries for Subacute Thyroiditis

KEGG : 37
Subacute thyroiditis (SAT), also called subacute granulomatous or de Quervain thyroiditis, is a spontaneously remitting, painful, inflammatory disease of the thyroid gland, which is considered the most common cause of painful thyroiditis. It is an uncommon but important cause of fever of unknown origin (FUO). SAT is often preceded by an upper respiratory tract infection and occurs concurrently with outbreaks of viral diseases (mumps, measles, influenza). However, the exact etiology is unknown. Clinically, it presents with acute onset of pain in the thyroid region. The pain may be exacerbated by turning the head or swallowing, and may radiate to the jaw, ear or chest. Common initial clinical features include low-grade fever, fatigue, and mild thyrotoxic manifestations. The physical examination, an elevated erythrocyte sedimentation rate, an elevated thyroglobulin level, and a depressed radioactive iodine uptake confirm the diagnosis. Therapy with antithyroid drugs is not indicated in patients with SAT because this disorder is caused by the release of preformed thyroid hormone rather than synthesis of new T3 and T4. Therapy with beta blockers may be indicated for the symptomatic treatment of thyrotoxicosis. Nonsteroidal anti-inflammatory drugs are generally effective in reducing thyroid pain in patients with mild cases. Patients with more severe disease require a tapering dosage of prednisone given over two to four weeks.

MalaCards based summary : Subacute Thyroiditis, also known as subacute granulomatous thyroiditis, is related to suppurative thyroiditis and thyroiditis. An important gene associated with Subacute Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Allograft rejection and Aldosterone synthesis and secretion. The drugs Prednisone and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and pituitary, and related phenotype is immune system.

Wikipedia : 75 Subacute thyroiditis is a form of thyroiditis that can be a cause of both thyrotoxicosis and... more...

Related Diseases for Subacute Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Subacute Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 suppurative thyroiditis 30.8 TG CRP
2 thyroiditis 30.6 TSHR TPO TG SERPINA7
3 thyroid crisis 30.4 TG SERPINA7
4 temporal arteritis 30.1 IL6 CRP
5 subacute lymphocytic thyroiditis 30.0 TPO TG
6 adult-onset still's disease 30.0 IL6 CRP
7 endocarditis 30.0 IL6 CRP
8 exanthem 30.0 IL6 CRP
9 brucellosis 29.9 IL6 CRP
10 hashimoto thyroiditis 29.9 TSHR TPO TG
11 typhoid fever 29.9 IL6 CRP
12 graves disease 1 29.8 TSHR TPO TG SERPINA7
13 graves' disease 29.8 TSHR TPO TG SERPINA7
14 goiter 29.7 TSHR TPO TG SERPINA7
15 thrombocytosis 29.7 IL6 CRP
16 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.7 TSHR TPO TG
17 chlamydia 29.6 IL6 CRP
18 autoimmune disease 29.6 TPO TG IL6
19 multinodular goiter 29.6 TSHR TPO TG
20 papillary carcinoma 29.5 TSHR TPO TG
21 thyroid cancer, nonmedullary, 2 29.3 TSHR TPO TG
22 hyperthyroxinemia 29.0 TSHR TPO SERPINA7
23 thyroid gland disease 29.0 TSHR TPO TG SERPINA7
24 hypothyroidism 29.0 TSHR TPO TG SHBG SERPINA7
25 plummer's disease 28.9 TPO TG SHBG
26 nodular goiter 28.6 TSHR TPO TG IL6
27 hyperthyroidism 28.4 TSHR TPO TG SHBG SERPINA7 SERPINA6
28 dyshormonogenic goiter 10.5 TG SERPINA7
29 pulmonary aspergilloma 10.5 TG CRP
30 benign struma ovarii 10.4 TSHR TG
31 struma ovarii 10.4 TSHR TG
32 athyreosis 10.4 TSHR TG
33 postsurgical hypothyroidism 10.4 TSHR TG
34 corticosteroid-binding globulin deficiency 10.4 SERPINA7 SERPINA6
35 euthyroid sick syndrome 10.4 SERPINA7 IL6
36 papillary thyroid microcarcinoma 10.4 TSHR TG
37 exophthalmos 10.3 TSHR TG
38 cold agglutinin disease 10.3 IL6 CRP
39 cryopyrin-associated periodic syndrome 10.3 IL6 CRP
40 acute cholangitis 10.3 IL6 CRP
41 uremic pruritus 10.3 IL6 CRP
42 orbital disease 10.3 TSHR CRP
43 neutrophilia, hereditary 10.3 IL6 CRP
44 spinal disease 10.3 IL6 CRP
45 viral pneumonia 10.3 IL6 CRP
46 central nervous system vasculitis 10.3 IL6 CRP
47 relapsing polychondritis 10.3 IL6 CRP
48 multicentric castleman disease 10.3 IL6 CRP
49 castleman disease 10.3 IL6 CRP
50 cecal disease 10.3 IL6 CRP

Graphical network of the top 20 diseases related to Subacute Thyroiditis:



Diseases related to Subacute Thyroiditis

Symptoms & Phenotypes for Subacute Thyroiditis

MGI Mouse Phenotypes related to Subacute Thyroiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 CRP IL6 SERPINA6 TG TPO TSHR

Drugs & Therapeutics for Subacute Thyroiditis

Drugs for Subacute Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
4 Anti-Inflammatory Agents Phase 4
5 glucocorticoids Phase 4
6 Hormones Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Hormone Antagonists Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
2 Clinical Diagnostic Evaluation of Thyroid Nodules Not yet recruiting NCT03884140

Search NIH Clinical Center for Subacute Thyroiditis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Betamethasone
Bupivacaine
Cortisone acetate
Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisolone
Prednisone
Triamcinolone

Cochrane evidence based reviews: thyroiditis, subacute

Genetic Tests for Subacute Thyroiditis

Anatomical Context for Subacute Thyroiditis

MalaCards organs/tissues related to Subacute Thyroiditis:

41
Thyroid, Testes, Pituitary, T Cells, Liver, Eye, Bone Marrow

Publications for Subacute Thyroiditis

Articles related to Subacute Thyroiditis:

(show top 50) (show all 994)
# Title Authors PMID Year
1
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 9 38
17887926 2007
2
"Thyrotoxic psychosis" associated with subacute thyroiditis. 9 38
17713314 2007
3
Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis. 9 38
11506478 2001
4
[Serum thyroglobulin measurement and its clinical significance]. 9 38
10483254 1999
5
Identification of thyroid hormone residues on serum thyroglobulin: a clue to the source of circulating thyroglobulin in thyroid diseases. 9 38
10229914 1999
6
Reactivity of anti-thyroid antibodies to thyroglobulin tryptic fragments: comparison of autoimmune and non-autoimmune thyroid diseases. 9 38
10347809 1999
7
[Correlation of ultrasound and radioisotope studies in subacute de Quervain thyroiditis]. 9 38
10518399 1999
8
Analyses of the molecular forms of serum thyroglobulin from patients with Graves' disease, subacute thyroiditis or differentiated thyroid cancer by velocity sedimentation on sucrose gradient and Western blot. 9 38
9849814 1998
9
[Diagnostic value of thyroid antibodies]. 9 38
8966023 1996
10
Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid. 9 38
8636270 1996
11
Thyroid primary and metastatic malignant tumours of poor prognosis may mimic subacute thyroiditis - time to change the diagnostic criteria: case reports and a review of the literature. 38
31387553 2019
12
Female Patient with Simultaneous Occurrence of Subacute Thyroiditis and Focal Autonomy. 38
31412373 2019
13
Subacute thyroiditis by dasatinib. 38
31351661 2019
14
Putting All the Pieces Together: Clinical, Macroscopic and Microscopic Characteristics of Subacute Thyroiditis. 38
29427032 2019
15
Life-threatening Misdiagnosis of Bulbar Type Onset Myasthenia Gravis as a Subacute Thyroiditis. 38
31260558 2019
16
A Case of Dynamic Evolution of Thyrotoxicosis on Follow-up. 38
31142404 2019
17
Serum autotaxin levels are associated with Graves' disease. 38
30814442 2019
18
Metabolomics and Their Ability to Distinguish Thyroid Disorders: A Retrospective Pilot Study. 38
30791054 2019
19
Treatment of lidocaine on subacute thyroiditis via restraining inflammatory factor expression and inhibiting pyroptosis pathway. 38
30963625 2019
20
The Risk of Recurrence of Subacute Thyroiditis Is HLA-Dependent. 38
30832406 2019
21
Clinical characteristics of subacute thyroiditis is different than it used to be - current state based on 15 years own material. 38
30860680 2019
22
Initial treatment combined with Prunella vulgaris reduced prednisolone consumption for patients with subacute thyroiditis. 38
30906749 2019
23
Kyphoscoliosis with Klippel-Trenaunay syndrome: a case report and literature review. 38
30611239 2019
24
Thyroid Diagnosis from SPECT Images Using Convolutional Neural Network with Optimization. 38
30766599 2019
25
Sonographic Pattern of Subacute Thyroiditis Is HLA-Dependent. 38
30728805 2019
26
Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects. 38
30936776 2019
27
[General practitioner management of subacute thyroiditis]. 38
30318408 2019
28
Clostridium difficile colitis in the setting of subacute thyroiditis: the chicken or the egg. 38
30567894 2018
29
Erratum: Occurrence of Subacute Thyroiditis following Influenza Vaccination. 38
30766840 2018
30
Sustained ventricular tachycardia caused by subacute thyroiditis. 38
30182396 2018
31
Occurrence of Subacute Thyroiditis following Influenza Vaccination. 38
30294587 2018
32
Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report. 38
29315620 2018
33
Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients. 38
30210035 2018
34
[Challenges in the management of amiodarone-induced thyrotoxicosis]. 38
30274916 2018
35
TNF-alpha is upregulated in subacute thyroiditis and stimulates expression of miR-155-5p in thyroid follicle cells. 38
30399324 2018
36
Subacute thyroiditis in a patient with psoriasis treated with a tumor necrosis factor-α inhibitor. 38
29460956 2018
37
Subacute Thyroiditis: A Rare Complication of Dengue. 38
31331159 2018
38
[Misdiagnosic analysis and treatment of pyriform sinus fistula in children]. 38
29764021 2018
39
The value of shear wave elastography in diffuse thyroid disease. 38
29627743 2018
40
[Atypical subacute thyroiditis in combination with Grave's disease:Diagnostic difficulties in a case report]. 38
29664539 2018
41
Asymptomatic thyroiditis presenting as pyrexia of unknown origin: a case report. 38
29471868 2018
42
Transiently Altered Distribution of F-18 FDG in a Patient with Subacute Thyroiditis. 38
29391918 2018
43
Fever of Unknown Origin as a Sole Presentation of Subacute Thyroiditis in an Elderly Patient: A Case Report with Literature Review. 38
30498605 2018
44
Diagnostic Values of Free Triiodothyronine and Free Thyroxine and the Ratio of Free Triiodothyronine to Free Thyroxine in Thyrotoxicosis. 38
29971103 2018
45
A Case of Thyrotoxicosis due to Simultaneous Occurrence of Subacute Thyroiditis and Graves' Disease. 38
30510812 2018
46
Significance of perithyroidal lymph nodes in benign thyroid diseases. 38
28656512 2018
47
Acute Suppurative Thyroiditis in an Intravenous Drug User with a Preexisting Goiter. 38
29780423 2018
48
Thyroid Abscess: Challenges in Diagnosis and Management. 38
29854858 2018
49
Subacute thyroiditis in psoriatic arthritis treated by adalimumab. 38
27825573 2017
50
[Etanercept-induced subacute thyroiditis. Case report and literature review]. 38
28942661 2017

Variations for Subacute Thyroiditis

Expression for Subacute Thyroiditis

Search GEO for disease gene expression data for Subacute Thyroiditis.

Pathways for Subacute Thyroiditis

GO Terms for Subacute Thyroiditis

Cellular components related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 TPO SERPINA7 SERPINA6 IL6 CRP
2 extracellular region GO:0005576 9.1 TG SHBG SERPINA7 SERPINA6 IL6 CRP

Biological processes related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.16 IL6 CRP
2 hormone biosynthetic process GO:0042446 8.96 TPO TG
3 negative regulation of lipid storage GO:0010888 8.62 IL6 CRP

Molecular functions related to Subacute Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid binding GO:0005496 8.62 SHBG SERPINA6

Sources for Subacute Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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