MCID: SBR003
MIFTS: 29

Subareolar Duct Papillomatosis

Categories: Cancer diseases

Aliases & Classifications for Subareolar Duct Papillomatosis

MalaCards integrated aliases for Subareolar Duct Papillomatosis:

Name: Subareolar Duct Papillomatosis 12 15
Adenoma of the Nipple 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7533
NCIt 49 C9008
UMLS 71 C0334378

Summaries for Subareolar Duct Papillomatosis

MalaCards based summary : Subareolar Duct Papillomatosis, also known as adenoma of the nipple, is related to papilloma and adenoma, and has symptoms including nipple discharge An important gene associated with Subareolar Duct Papillomatosis is CNN1 (Calponin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include breast, skin and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 A nipple adenoma is a rare benign tumour of the... more...

Related Diseases for Subareolar Duct Papillomatosis

Diseases related to Subareolar Duct Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 papilloma 29.8 KRT8 KRT7 KRT5
2 adenoma 10.3
3 laryngeal small cell carcinoma 10.2 KRT5 CNN1
4 lung leiomyosarcoma 10.2 KRT5 CALD1
5 colon leiomyosarcoma 10.2 KRT5 CALD1
6 perivascular epithelioid cell tumor 10.2 MME CALD1
7 testicular fibroma 10.2 KRT5 CALD1
8 mixed endometrial stromal and smooth muscle tumor 10.2 MME CALD1
9 smooth muscle tumor 10.2 MME CALD1
10 vaginal endometrial stromal tumor 10.2 MME CALD1
11 endometrial stromal tumor 10.2 MME CALD1
12 fallopian tube leiomyoma 10.2 MME CALD1
13 urethra leiomyoma 10.2 MME CALD1
14 fallopian tube benign neoplasm 10.2 MME CALD1
15 breast myofibroblastoma 10.2 MME CALD1
16 paranasal sinus lymphoma 10.2 MME CNN1
17 lung combined type small cell carcinoma 10.2 MME CALD1
18 cervical mucinous adenocarcinoma 10.2 KRT7 CALD1
19 nephrogenic adenofibroma 10.2 KRT7 CALD1
20 esophagus sarcoma 10.2 KRT5 CALD1
21 intravenous leiomyomatosis 10.2 MME CALD1
22 cervical polyp 10.2 MME CALD1
23 ureter squamous cell carcinoma 10.2 KRT7 KRT5
24 inverted transitional papilloma 10.2 KRT7 KRT5
25 endometrial stromal nodule 10.2 MME CALD1
26 ureter adenocarcinoma 10.2 KRT7 KRT5
27 ceruminoma 10.2 KRT7 KRT5
28 malignant acrospiroma 10.2 KRT7 KRT5
29 vulvar leiomyoma 10.2 MME CALD1
30 cellular leiomyoma 10.1 MME CALD1
31 atypical polypoid adenomyoma 10.1 MME CALD1
32 microinvasive cervical squamous cell carcinoma 10.1 KRT7 KRT5
33 cutaneous mucoepidermoid carcinoma 10.1 KRT7 KRT5
34 auditory system benign neoplasm 10.1 KRT7 KRT5
35 ceruminous adenocarcinoma 10.1 KRT7 KRT5
36 eccrine adenocarcinoma 10.1 KRT7 KRT5
37 cervix erosion 10.1 MME KRT5
38 external ear carcinoma 10.1 KRT7 KRT5
39 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT5
40 apocrine adenocarcinoma 10.1 KRT7 KRT5
41 breast leiomyosarcoma 10.1 KRT7 CALD1
42 ovarian endometrioid stromal sarcoma 10.1 MME CALD1
43 middle ear adenoma 10.1 KRT7 KRT5
44 lung clear cell carcinoma 10.1 KRT7 KRT5
45 gastric squamous cell carcinoma 10.1 KRT7 KRT5
46 necrotizing sialometaplasia 10.1 KRT7 KRT5
47 endobronchial leiomyoma 10.1 MME CALD1
48 sensory organ benign neoplasm 10.1 KRT7 KRT5
49 breast metaplastic carcinoma 10.1 MME KRT5
50 bile duct mucoepidermoid carcinoma 10.1 KRT7 KRT5

Graphical network of the top 20 diseases related to Subareolar Duct Papillomatosis:



Diseases related to Subareolar Duct Papillomatosis

Symptoms & Phenotypes for Subareolar Duct Papillomatosis

UMLS symptoms related to Subareolar Duct Papillomatosis:


nipple discharge

GenomeRNAi Phenotypes related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.1 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.1 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.1 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.1 KRT5 KRT7 KRT8

Drugs & Therapeutics for Subareolar Duct Papillomatosis

Search Clinical Trials , NIH Clinical Center for Subareolar Duct Papillomatosis

Genetic Tests for Subareolar Duct Papillomatosis

Anatomical Context for Subareolar Duct Papillomatosis

MalaCards organs/tissues related to Subareolar Duct Papillomatosis:

40
Breast, Skin, Lymph Node

Publications for Subareolar Duct Papillomatosis

Articles related to Subareolar Duct Papillomatosis:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Clinical and sonographic features of nipple lesions. 61
32282731 2020
2
MOHS micrographic surgery for treating erosive adenoma of the nipple: a case report and review of the literature. 61
28960299 2017
3
[A Case of Adenoma of the Nipple Suspected of Breast Cancer]. 61
29394537 2017
4
Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. 61
27206635 2016
5
[How to explore breast skin lesion?: Guidelines]. 61
26527029 2015
6
Syringomatous adenoma of the nipple: a case report. 61
26564150 2015
7
Cytologic features of nipple adenoma: a report of four cases of adenoma of the nipple. 61
26011103 2015
8
Dermoscopic observation in adenoma of the nipple. 61
25639650 2015
9
Bilateral synchronous low-grade adenosquamous carcinoma of the breast: A Case report with review of the current literature. 61
26218176 2015
10
Infiltrating syringomatous adenoma of the nipple: Sonographic and mammographic features with pathologic correlation. 61
24648330 2014
11
Adenoma of the nipple: A clinicopathological report of 13 cases. 61
24932244 2014
12
Bilateral syringomatous adenomas of the nipple: Case report with immunohistochemical characterization of a rare tumor mimicking malignancy. 61
24713747 2014
13
Adenoma of the nipple projecting out of the nipple: curative resection without excision of the nipple. 61
24716784 2014
14
Infiltrating syringomatous adenoma of the nipple: a case report. 61
24034396 2013
15
[Pathologic diagnosis and differential diagnosis of low-grade adenosquamous carcinoma of breast and syringomatous adenoma of nipple]. 61
22883667 2012
16
A case of syringomatous adenoma of the nipple. 61
22649338 2012
17
Adenoma of the nipple, focusing on the contrast-enhanced magnetic resonance imaging findings: report of a case. 61
21773907 2011
18
Immunophenotype of nipple adenoma in a male patient. 61
21030863 2011
19
Florid papillomatosis of the male nipple. 61
20409515 2010
20
Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. 61
19469876 2009
21
Infiltrating syringomatous eccrine adenoma of the nipple: a case report. 61
20062695 2009
22
Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review. 61
19722761 2009
23
Infiltrating syringomatous adenoma of the nipple. 61
19470133 2009
24
Infiltrating syringomatous adenoma of nipple. 61
18760070 2008
25
Syringomatous adenoma of the nipple--treatment by central mound resection and oncoplastic reconstruction. 61
18186873 2008
26
Syringomatous adenoma of the nipple: report of a case. 61
18306564 2007
27
Adenoma of the nipple in a Japanese man. 61
17362232 2007
28
A rare case of invasive ductal carcinoma with hyperprolactinemia. 61
17690509 2007
29
Ectopic breast tissue in axillary lymph node. 61
17986810 2007
30
Adenoma of the nipple: correlation of magnetic resonance imaging findings with histologic features. 61
16365591 2006
31
Adenoma of the nipple: report of a case. 61
16518068 2006
32
[Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. 61
16047925 2005
33
Syringomatous adenoma of the nipple: a case report. 61
16047951 2005
34
Syringomatous adenoma of the nipple. 61
15454197 2004
35
Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. 61
15327500 2004
36
Syringomatous adenoma of the nipple: a case report. 61
15550871 2004
37
Syringomatous adenoma of the nipple: a case report. 61
14506979 2003
38
A case of male noninvasive intracystic papillary carcinoma forming a tumor in the nipple duct. 61
12525769 2003
39
[Adenomas of the nipple]. 61
12370674 2002
40
[Rare pathology of the breast: adenoma of the nipple]. 61
12228975 2002
41
Adenoma of the nipple in an adolescent. 61
12185338 2002
42
[Infiltrating syringoadenoma of the nipple: a new case]. 61
10740011 2000
43
Syringomatous adenoma of the nipple. 61
11247392 2000
44
[Adenoma of the nipples. A rare, but essential differential diagnosis]. 61
10578697 1999
45
[Adenoma of the nipple. Three cases studies with ultrasonography]. 61
10432983 1999
46
Fine-needle aspiration cytology and immunohistology of low-grade adenosquamous carcinoma of the breast. 61
9884821 1999
47
Enhancement of the Nipple-Areolar-Complex on Contrast-Enhanced MR Imaging of the Breast. 61
11091660 1998
48
Syringomatous adenoma of the nipple: report of a case. 61
9851633 1998
49
[Syringomatous tumor of the nipple. A case report and review of the literature]. 61
9768107 1997
50
Fine needle aspiration cytology of adenoma of the nipple. A case report. 61
8693907 1996

Variations for Subareolar Duct Papillomatosis

Cosmic variations for Subareolar Duct Papillomatosis:

9 (show all 11)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87132301 PIK3CA breast,nipple,other,adenoma c.1624G>A p.E542K 3:179218294-179218294 3
2 COSM87132245 PIK3CA breast,nipple,other,adenoma c.3140A>G p.H1047R 3:179234297-179234297 3
3 COSM87805079 KRAS breast,nipple,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 3
4 COSM150563774 BRAF breast,nipple,other,adenoma c.1799T>A p.V600E 7:140753336-140753336 3
5 COSM88803061 breast,nipple,other,adenoma c.1919T>A p.V640E 7:140753336-140753336 3
6 COSM148932633 breast,nipple,other,adenoma c.*220A>G p.? 3:179234297-179234297 3
7 COSM134616172 breast,nipple,other,adenoma c.112-17430A>C p.? 12:25227341-25227341 3
8 COSM91860399 breast,nipple,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 3
9 COSM149385292 breast,nipple,other,adenoma c.1919T>A p.V640E 7:140753336-140753336 3
10 COSM118787231 breast,nipple,other,adenoma c.1799T>A p.V600E 7:140753336-140753336 3
11 COSM148932717 breast,nipple,other,adenoma c.1624G>A p.E542K 3:179218294-179218294 3

Expression for Subareolar Duct Papillomatosis

Search GEO for disease gene expression data for Subareolar Duct Papillomatosis.

Pathways for Subareolar Duct Papillomatosis

Pathways related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT8 KRT7 KRT5
2 11.51 KRT8 KRT7 KRT5 CNN1 CALD1
3
Show member pathways
11.17 KRT8 KRT7 KRT5
4 11.13 MME KRT8

GO Terms for Subareolar Duct Papillomatosis

Cellular components related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT8 KRT7 KRT5
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT8 KRT7 KRT5
2 cornification GO:0070268 8.8 KRT8 KRT7 KRT5

Molecular functions related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT8 KRT5

Sources for Subareolar Duct Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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