MCID: SBR003
MIFTS: 29

Subareolar Duct Papillomatosis

Categories: Cancer diseases

Aliases & Classifications for Subareolar Duct Papillomatosis

MalaCards integrated aliases for Subareolar Duct Papillomatosis:

Name: Subareolar Duct Papillomatosis 12 15
Adenoma of the Nipple 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7533
NCIt 50 C9008
UMLS 71 C0334378

Summaries for Subareolar Duct Papillomatosis

MalaCards based summary : Subareolar Duct Papillomatosis, also known as adenoma of the nipple, is related to papilloma and adenoma, and has symptoms including nipple discharge An important gene associated with Subareolar Duct Papillomatosis is CNN1 (Calponin 1), and among its related pathways/superpathways are Keratinization and Cytoskeletal Signaling. Affiliated tissues include skin and lymph node, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 A nipple adenoma is a rare benign tumour of the... more...

Related Diseases for Subareolar Duct Papillomatosis

Diseases related to Subareolar Duct Papillomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 papilloma 29.8 KRT8 KRT7 KRT5
2 adenoma 10.2
3 breast leiomyosarcoma 10.1 KRT7 CALD1
4 colon leiomyosarcoma 10.1 KRT5 CALD1
5 testicular fibroma 10.1 KRT5 CALD1
6 papillary adenoma 10.1 KRT7 KRT5
7 ureter squamous cell carcinoma 10.1 KRT7 KRT5
8 inverted transitional papilloma 10.1 KRT7 KRT5
9 ceruminoma 10.1 KRT7 KRT5
10 ureter adenocarcinoma 10.1 KRT7 KRT5
11 malignant acrospiroma 10.1 KRT7 KRT5
12 auditory system benign neoplasm 10.1 KRT7 KRT5
13 microinvasive cervical squamous cell carcinoma 10.1 KRT7 KRT5
14 perivascular epithelioid cell tumor 10.1 MME CALD1
15 ceruminous adenocarcinoma 10.1 KRT7 KRT5
16 bladder leiomyoma 10.1 KRT7 CALD1
17 cutaneous mucoepidermoid carcinoma 10.1 KRT7 KRT5
18 external ear carcinoma 10.1 KRT7 KRT5
19 esophagus sarcoma 10.1 KRT5 CALD1
20 eccrine adenocarcinoma 10.1 KRT7 KRT5
21 lung clear cell carcinoma 10.1 KRT7 KRT5
22 vulvar apocrine adenocarcinoma 10.1 KRT7 KRT5
23 apocrine adenocarcinoma 10.1 KRT7 KRT5
24 myoma 10.1 MME CALD1
25 papillary squamous carcinoma 10.1 KRT7 KRT5
26 necrotizing sialometaplasia 10.1 KRT7 KRT5
27 sensory organ benign neoplasm 10.1 KRT7 KRT5
28 malignant syringoma 10.1 KRT7 KRT5
29 vaginal endometrial stromal tumor 10.1 MME CALD1
30 endometrial stromal tumor 10.1 MME CALD1
31 gastric squamous cell carcinoma 10.1 KRT7 KRT5
32 mixed endometrial stromal and smooth muscle tumor 10.1 MME CALD1
33 bile duct mucoepidermoid carcinoma 10.1 KRT7 KRT5
34 smooth muscle tumor 10.1 MME CALD1
35 fallopian tube leiomyoma 10.1 MME CALD1
36 urethra leiomyoma 10.1 MME CALD1
37 fallopian tube benign neoplasm 10.1 MME CALD1
38 breast myofibroblastoma 10.1 MME CALD1
39 middle ear adenocarcinoma 10.1 KRT7 KRT5
40 large cell acanthoma 10.1 KRT7 KRT5
41 breast mucinous carcinoma 10.1 KRT7 KRT5
42 pericardium cancer 10.1 KRT7 KRT5
43 lung combined type small cell carcinoma 10.1 MME CALD1
44 eccrine sweat gland cancer 10.1 KRT7 KRT5
45 retroperitoneum carcinoma 10.1 KRT7 CALD1
46 eccrine acrospiroma 10.1 KRT7 KRT5
47 mucinous stomach adenocarcinoma 10.1 KRT7 KRT5
48 eccrine sweat gland neoplasm 10.1 KRT7 KRT5
49 esophageal adenosquamous carcinoma 10.1 KRT7 KRT5
50 cervical polyp 10.1 MME CALD1

Graphical network of the top 20 diseases related to Subareolar Duct Papillomatosis:



Diseases related to Subareolar Duct Papillomatosis

Symptoms & Phenotypes for Subareolar Duct Papillomatosis

UMLS symptoms related to Subareolar Duct Papillomatosis:


nipple discharge

GenomeRNAi Phenotypes related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.28 KRT5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-182 9.28 KRT5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.28 KRT8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.28 KRT7 KRT8 KRT5

Drugs & Therapeutics for Subareolar Duct Papillomatosis

Search Clinical Trials , NIH Clinical Center for Subareolar Duct Papillomatosis

Genetic Tests for Subareolar Duct Papillomatosis

Anatomical Context for Subareolar Duct Papillomatosis

MalaCards organs/tissues related to Subareolar Duct Papillomatosis:

40
Skin, Lymph Node

Publications for Subareolar Duct Papillomatosis

Articles related to Subareolar Duct Papillomatosis:

(show top 50) (show all 90)
# Title Authors PMID Year
1
Syringomatous adenoma of the nipple with microcalcifications on mammography: A case report. 61
33368840 2021
2
[Multiple Calcification of the Nipple Areola Complex: a Case Report of Infiltrating Syringomatous Adenoma of the Nipple]. 61
33236616 2020
3
Recurrent syringomatous adenoma of the nipple following a misdiagnosis: A case report. 61
32913175 2020
4
Clinical and sonographic features of nipple lesions. 61
32282731 2020
5
MOHS micrographic surgery for treating erosive adenoma of the nipple: a case report and review of the literature. 61
28960299 2017
6
[A Case of Adenoma of the Nipple Suspected of Breast Cancer]. 61
29394537 2017
7
Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. 61
27206635 2016
8
[How to explore breast skin lesion?: Guidelines]. 61
26527029 2015
9
Syringomatous adenoma of the nipple: a case report. 61
26564150 2015
10
Cytologic features of nipple adenoma: a report of four cases of adenoma of the nipple. 61
26011103 2015
11
Dermoscopic observation in adenoma of the nipple. 61
25639650 2015
12
Bilateral synchronous low-grade adenosquamous carcinoma of the breast: A Case report with review of the current literature. 61
26218176 2015
13
Infiltrating syringomatous adenoma of the nipple: Sonographic and mammographic features with pathologic correlation. 61
24648330 2014
14
Adenoma of the nipple: A clinicopathological report of 13 cases. 61
24932244 2014
15
Bilateral syringomatous adenomas of the nipple: Case report with immunohistochemical characterization of a rare tumor mimicking malignancy. 61
24713747 2014
16
Adenoma of the nipple projecting out of the nipple: curative resection without excision of the nipple. 61
24716784 2014
17
Infiltrating syringomatous adenoma of the nipple: a case report. 61
24034396 2013
18
[Pathologic diagnosis and differential diagnosis of low-grade adenosquamous carcinoma of breast and syringomatous adenoma of nipple]. 61
22883667 2012
19
A case of syringomatous adenoma of the nipple. 61
22649338 2012
20
Adenoma of the nipple, focusing on the contrast-enhanced magnetic resonance imaging findings: report of a case. 61
21773907 2011
21
Immunophenotype of nipple adenoma in a male patient. 61
21030863 2011
22
Florid papillomatosis of the male nipple. 61
20409515 2010
23
Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. 61
19469876 2009
24
Infiltrating syringomatous eccrine adenoma of the nipple: a case report. 61
20062695 2009
25
Infiltrating syringomatous adenoma of the nipple: clinical presentation and literature review. 61
19722761 2009
26
Infiltrating syringomatous adenoma of the nipple. 61
19470133 2009
27
Infiltrating syringomatous adenoma of nipple. 61
18760070 2008
28
Syringomatous adenoma of the nipple--treatment by central mound resection and oncoplastic reconstruction. 61
18186873 2008
29
Syringomatous adenoma of the nipple: report of a case. 61
18306564 2007
30
Adenoma of the nipple in a Japanese man. 61
17362232 2007
31
A rare case of invasive ductal carcinoma with hyperprolactinemia. 61
17690509 2007
32
Ectopic breast tissue in axillary lymph node. 61
17986810 2007
33
Adenoma of the nipple: report of a case. 61
16518068 2006
34
Adenoma of the nipple: correlation of magnetic resonance imaging findings with histologic features. 61
16365591 2006
35
[Metastasing and relapsing "low grade" adenosquamous metaplastic breast cancer--is there a really indolent lesion? A description of three cases and review of literature]. 61
16047925 2005
36
Syringomatous adenoma of the nipple: a case report. 61
16047951 2005
37
Syringomatous adenoma of the nipple. 61
15454197 2004
38
Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. 61
15327500 2004
39
Syringomatous adenoma of the nipple: a case report. 61
15550871 2004
40
Syringomatous adenoma of the nipple: a case report. 61
14506979 2003
41
A case of male noninvasive intracystic papillary carcinoma forming a tumor in the nipple duct. 61
12525769 2003
42
[Adenomas of the nipple]. 61
12370674 2002
43
[Rare pathology of the breast: adenoma of the nipple]. 61
12228975 2002
44
Adenoma of the nipple in an adolescent. 61
12185338 2002
45
[Infiltrating syringoadenoma of the nipple: a new case]. 61
10740011 2000
46
Syringomatous adenoma of the nipple. 61
11247392 2000
47
[Adenoma of the nipples. A rare, but essential differential diagnosis]. 61
10578697 1999
48
[Adenoma of the nipple. Three cases studies with ultrasonography]. 61
10432983 1999
49
Fine-needle aspiration cytology and immunohistology of low-grade adenosquamous carcinoma of the breast. 61
9884821 1999
50
Enhancement of the Nipple-Areolar-Complex on Contrast-Enhanced MR Imaging of the Breast. 61
11091660 1998

Variations for Subareolar Duct Papillomatosis

Cosmic variations for Subareolar Duct Papillomatosis:

9 (show all 11)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87132301 PIK3CA breast,nipple,other,adenoma c.1624G>A p.E542K 3:179218294-179218294 3
2 COSM87132245 PIK3CA breast,nipple,other,adenoma c.3140A>G p.H1047R 3:179234297-179234297 3
3 COSM148932633 PIK3CA breast,nipple,other,adenoma c.*220A>G p.? 3:179234297-179234297 3
4 COSM148932717 PIK3CA breast,nipple,other,adenoma c.1624G>A p.E542K 3:179218294-179218294 3
5 COSM134616172 KRAS breast,nipple,other,adenoma c.112-17430A>C p.? 12:25227341-25227341 3
6 COSM91860399 KRAS breast,nipple,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 3
7 COSM87805079 KRAS breast,nipple,other,adenoma c.183A>C p.Q61H 12:25227341-25227341 3
8 COSM88803061 BRAF breast,nipple,other,adenoma c.1919T>A p.V640E 7:140753336-140753336 3
9 COSM150563774 BRAF breast,nipple,other,adenoma c.1799T>A p.V600E 7:140753336-140753336 3
10 COSM149385292 BRAF breast,nipple,other,adenoma c.1919T>A p.V640E 7:140753336-140753336 3
11 COSM118787231 BRAF breast,nipple,other,adenoma c.1799T>A p.V600E 7:140753336-140753336 3

Expression for Subareolar Duct Papillomatosis

Search GEO for disease gene expression data for Subareolar Duct Papillomatosis.

Pathways for Subareolar Duct Papillomatosis

Pathways related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 KRT8 KRT7 KRT5
2 11.51 KRT8 KRT7 KRT5 CNN1 CALD1
3
Show member pathways
11.17 KRT8 KRT7 KRT5
4 11.13 MME KRT8

GO Terms for Subareolar Duct Papillomatosis

Cellular components related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 9.13 KRT8 KRT7 KRT5
2 keratin filament GO:0045095 8.8 KRT8 KRT7 KRT5

Biological processes related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT8 KRT7 KRT5
2 cornification GO:0070268 8.8 KRT8 KRT7 KRT5

Molecular functions related to Subareolar Duct Papillomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 scaffold protein binding GO:0097110 8.62 KRT8 KRT5

Sources for Subareolar Duct Papillomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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