MCID: SBC025
MIFTS: 24

Subcortical Arteriosclerotic Encephalopathy

Categories: Cardiovascular diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Subcortical Arteriosclerotic Encephalopathy

MalaCards integrated aliases for Subcortical Arteriosclerotic Encephalopathy:

Name: Subcortical Arteriosclerotic Encephalopathy 55
Binswanger Disease 74

Classifications:



External Ids:

UMLS 74 C0270786

Summaries for Subcortical Arteriosclerotic Encephalopathy

NINDS : 55 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Subcortical Arteriosclerotic Encephalopathy, also known as binswanger disease, is related to binswanger's disease and encephalopathy. An important gene associated with Subcortical Arteriosclerotic Encephalopathy is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways is Neuroscience. The drugs Acetaminophen and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and smooth muscle.

Wikipedia : 77 Binswanger''s disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic... more...

Related Diseases for Subcortical Arteriosclerotic Encephalopathy

Diseases related to Subcortical Arteriosclerotic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 binswanger's disease 32.3 GFAP VIP
2 encephalopathy 11.0
3 hydrocephalus, normal-pressure 10.4
4 hydrocephalus 10.4
5 dementia 10.4
6 cerebral amyloid angiopathy, cst3-related 10.3
7 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.1
8 multiple sclerosis 10.1
9 aceruloplasminemia 10.1
10 depression 10.1
11 fetal alcohol syndrome 9.6 GFAP VIP
12 ganglioneuroma 9.5 GFAP VIP

Graphical network of the top 20 diseases related to Subcortical Arteriosclerotic Encephalopathy:



Diseases related to Subcortical Arteriosclerotic Encephalopathy

Symptoms & Phenotypes for Subcortical Arteriosclerotic Encephalopathy

Drugs & Therapeutics for Subcortical Arteriosclerotic Encephalopathy

Drugs for Subcortical Arteriosclerotic Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
3 Central Nervous System Depressants Phase 4
4 Peripheral Nervous System Agents Phase 4
5 Analgesics, Opioid Phase 4
6 Antipyretics Phase 4
7 Narcotics Phase 4
8 Analgesics Phase 4
9 Narcotic Antagonists Phase 4
10 Analgesics, Non-Narcotic Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Pain Treatment on Depression in Patients With Dementia Completed NCT02267057 Phase 4 Paracetamol;Buprenorphine;Paracetamol placebo;Buprenorphine placebo
2 Secondary Prevention of Stroke Through Non-drug Therapeutic Weight Reduction Unknown status NCT01721538 Not Applicable
3 Identification of Biomarkers Sensitive to Disease Progression in Patients With Mild Cognitive Impairment Completed NCT01425957 Not Applicable

Search NIH Clinical Center for Subcortical Arteriosclerotic Encephalopathy

Genetic Tests for Subcortical Arteriosclerotic Encephalopathy

Anatomical Context for Subcortical Arteriosclerotic Encephalopathy

MalaCards organs/tissues related to Subcortical Arteriosclerotic Encephalopathy:

42
Brain, Endothelial, Smooth Muscle

Publications for Subcortical Arteriosclerotic Encephalopathy

Articles related to Subcortical Arteriosclerotic Encephalopathy:

(show top 50) (show all 67)
# Title Authors Year
1
Binswanger disease may benefit from omental arteries. ( 25657857 )
2015
2
Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease. ( 26205374 )
2015
3
Binswanger disease--an update. ( 20875648 )
2010
4
White matter diffusion is higher in Binswanger disease than in idiopathic normal pressure hydrocephalus. ( 19485951 )
2009
5
Elevated CNS concentrations of NFL in idiopathic normal pressure hydrocephalus (INPH) and subcortical arteriosclerotic encephalopathy (SAE). ( 18307570 )
2008
6
Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). ( 17340101 )
2007
7
Differentiation of multiple sclerosis plaques, subacute cerebral ischaemic infarcts, focal vasogenic oedema and lesions of subcortical arteriosclerotic encephalopathy using magnetisation transfer measurements. ( 12700877 )
2003
8
White matter changes in normal pressure hydrocephalus and Binswanger disease: specificity, predictive value and correlations to axonal degeneration and demyelination. ( 12027829 )
2002
9
Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison. ( 11161160 )
2001
10
Psychotic depression, subcortical arteriosclerotic encephalopathy and holocaust-conditioned posttraumatic stress disorder. ( 11270447 )
2001
11
Leukoaraiosis three-dimensional in Binswanger disease. ( 11245711 )
2001
12
The coagulation-fibrinolysis system in patients with leukoaraiosis and Binswanger disease. ( 11594920 )
2001
13
CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. ( 10864607 )
2000
14
Binswanger disease: the history of a silent epidemic. ( 10818484 )
2000
15
Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease. ( 11065253 )
2000
16
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
17
Comparative analysis of gait in Parkinson's disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. ( 10388800 )
1999
18
New insight into Binswanger disease. ( 10488805 )
1999
19
Coagulation activation in patients with Binswanger disease. ( 10488811 )
1999
20
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
21
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly. ( 9341699 )
1997
22
Parkinsonism due to Binswanger's subcortical arteriosclerotic encephalopathy. ( 8813238 )
1996
23
Occurrence of paroxysmal synchronous EEG discharges in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 8329820 )
1993
24
Binswanger disease: The King Khalid University Hospital experience. ( 17590723 )
1993
25
Regional cerebral blood flow measured with I-123 IMP SPECT in a case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1424377 )
1992
26
Evaluation of dementia in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1834189 )
1991
27
Amyloid beta-protein in cerebral amyloid angiopathy, senile plaques, and preamyloidotic lesions in subcortical arteriosclerotic encephalopathy (Binswanger disease). ( 1857541 )
1991
28
White matter lesions and normal-pressure hydrocephalus: Binswanger disease or Hakim syndrome? ( 1899516 )
1991
29
Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation. ( 2252606 )
1990
30
Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 2614428 )
1989
31
Binswanger's disease (Part I): The clinical recognition of subcortical arteriosclerotic encephalopathy in elderly neuropsychiatric patients. ( 2686675 )
1989
32
Binswanger's disease (Part II): Pathogenesis of subcortical arteriosclerotic encephalopathy and its relation to other dementing processes. ( 2699555 )
1989
33
Subcortical arteriosclerotic encephalopathy--a controlled psychometric study. ( 2548788 )
1989
34
The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). ( 2674767 )
1989
35
Computerized tomographic findings and differential diagnostic considerations in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3179978 )
1988
36
Alterations of short-latency somatosensory evoked potentials in subcortical arteriosclerotic encephalopathy (Binswanger's Disease): a preliminary report. ( 3191878 )
1988
37
Effects of enzymatic blood defibrination in subcortical arteriosclerotic encephalopathy. ( 3063776 )
1988
38
Cerebral amyloid angiopathy with attenuation of the white matter on CT scans: subcortical arteriosclerotic encephalopathy (Binswanger) in a normotensive patient. ( 3221249 )
1988
39
Subcortical arteriosclerotic encephalopathy: a clinical and radionuclide brain scintiscan study. ( 3407386 )
1988
40
The corpus callosum, a unique white-matter tract: anatomic features that may explain sparing in Binswanger disease and resistance to flow of fluid masses. ( 3143229 )
1988
41
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Report of a case simulating psychiatric disease and normal pressure hydrocephalus. ( 3473291 )
1987
42
High-resolution nuclear magnetic resonance imaging and single photon emission computerized tomography--cerebral blood flow in a case of pure sensory stroke and mild dementia owing to subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3502532 )
1987
43
Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3504256 )
1987
44
The role of plasma hyperviscosity in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3559641 )
1987
45
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Presentation of two cases. ( 3604757 )
1987
46
Subcortical arteriosclerotic encephalopathy (Binswanger's disease): a report of five patients. ( 3618106 )
1987
47
Subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3665181 )
1987
48
Mental changes in subcortical arteriosclerotic encephalopathy. ( 2439247 )
1987
49
Subcortical arteriosclerotic encephalopathy: brain stem findings with MR imaging. ( 3685341 )
1987
50
Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. ( 3686582 )
1987

Variations for Subcortical Arteriosclerotic Encephalopathy

Expression for Subcortical Arteriosclerotic Encephalopathy

Search GEO for disease gene expression data for Subcortical Arteriosclerotic Encephalopathy.

Pathways for Subcortical Arteriosclerotic Encephalopathy

Pathways related to Subcortical Arteriosclerotic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 GFAP VIP

GO Terms for Subcortical Arteriosclerotic Encephalopathy

Sources for Subcortical Arteriosclerotic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
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37 IUPHAR
38 KEGG
39 LifeMap
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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