MCID: SBC025
MIFTS: 20

Subcortical Arteriosclerotic Encephalopathy

Categories: Cardiovascular diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Subcortical Arteriosclerotic Encephalopathy

MalaCards integrated aliases for Subcortical Arteriosclerotic Encephalopathy:

Name: Subcortical Arteriosclerotic Encephalopathy 54
Binswanger Disease 73

Classifications:



External Ids:

UMLS 73 C0270786

Summaries for Subcortical Arteriosclerotic Encephalopathy

NINDS : 54 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.  

MalaCards based summary : Subcortical Arteriosclerotic Encephalopathy, also known as binswanger disease, is related to binswanger's disease and encephalopathy. An important gene associated with Subcortical Arteriosclerotic Encephalopathy is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include brain, endothelial and smooth muscle.

Wikipedia : 76 Binswanger''s disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic... more...

Related Diseases for Subcortical Arteriosclerotic Encephalopathy

Diseases related to Subcortical Arteriosclerotic Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 binswanger's disease 32.4 GFAP VIP
2 encephalopathy 11.0
3 hydrocephalus, normal-pressure 10.4
4 hydrocephalus 10.4
5 dementia 10.4
6 cerebral amyloid angiopathy, cst3-related 10.3
7 multiple sclerosis 10.1
8 aceruloplasminemia 10.1
9 depression 10.1
10 fetal alcohol syndrome 9.8 GFAP VIP
11 ganglioneuroma 9.7 GFAP VIP

Graphical network of the top 20 diseases related to Subcortical Arteriosclerotic Encephalopathy:



Diseases related to Subcortical Arteriosclerotic Encephalopathy

Symptoms & Phenotypes for Subcortical Arteriosclerotic Encephalopathy

Drugs & Therapeutics for Subcortical Arteriosclerotic Encephalopathy

Search Clinical Trials , NIH Clinical Center for Subcortical Arteriosclerotic Encephalopathy

Genetic Tests for Subcortical Arteriosclerotic Encephalopathy

Anatomical Context for Subcortical Arteriosclerotic Encephalopathy

MalaCards organs/tissues related to Subcortical Arteriosclerotic Encephalopathy:

41
Brain, Endothelial, Smooth Muscle

Publications for Subcortical Arteriosclerotic Encephalopathy

Articles related to Subcortical Arteriosclerotic Encephalopathy:

(show top 50) (show all 66)
# Title Authors Year
1
Binswanger disease may benefit from omental arteries. ( 25657857 )
2015
2
Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease. ( 26205374 )
2015
3
Binswanger disease--an update. ( 20875648 )
2010
4
Elevated CNS concentrations of NFL in idiopathic normal pressure hydrocephalus (INPH) and subcortical arteriosclerotic encephalopathy (SAE). ( 18307570 )
2008
5
Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). ( 17340101 )
2007
6
Differentiation of multiple sclerosis plaques, subacute cerebral ischaemic infarcts, focal vasogenic oedema and lesions of subcortical arteriosclerotic encephalopathy using magnetisation transfer measurements. ( 12700877 )
2003
7
White matter changes in normal pressure hydrocephalus and Binswanger disease: specificity, predictive value and correlations to axonal degeneration and demyelination. ( 12027829 )
2002
8
Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison. ( 11161160 )
2001
9
Psychotic depression, subcortical arteriosclerotic encephalopathy and holocaust-conditioned posttraumatic stress disorder. ( 11270447 )
2001
10
Leukoaraiosis three-dimensional in Binswanger disease. ( 11245711 )
2001
11
The coagulation-fibrinolysis system in patients with leukoaraiosis and Binswanger disease. ( 11594920 )
2001
12
CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. ( 10864607 )
2000
13
Binswanger disease: the history of a silent epidemic. ( 10818484 )
2000
14
Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease. ( 11065253 )
2000
15
Comparative analysis of gait in Parkinson's disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. ( 10388800 )
1999
16
Increased coagulatory activity in subcortical arteriosclerotic encephalopathy (Binswanger's disease) ( 9987717 )
1999
17
New insight into Binswanger disease. ( 10488805 )
1999
18
Coagulation activation in patients with Binswanger disease. ( 10488811 )
1999
19
1H-MRS differentiates white matter hyperintensities in subcortical arteriosclerotic encephalopathy from those in normal elderly. ( 9341699 )
1997
20
The angiopathy of subcortical arteriosclerotic encephalopathy (Binswanger's disease): immunohistochemical studies using markers for components of extracellular matrix, smooth muscle actin and endothelial cells. ( 9083552 )
1997
21
Parkinsonism due to Binswanger's subcortical arteriosclerotic encephalopathy. ( 8813238 )
1996
22
Occurrence of paroxysmal synchronous EEG discharges in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 8329820 )
1993
23
Binswanger disease: The King Khalid University Hospital experience. ( 17590723 )
1993
24
Regional cerebral blood flow measured with I-123 IMP SPECT in a case of subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1424377 )
1992
25
Evaluation of dementia in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 1834189 )
1991
26
Amyloid beta-protein in cerebral amyloid angiopathy, senile plaques, and preamyloidotic lesions in subcortical arteriosclerotic encephalopathy (Binswanger disease). ( 1857541 )
1991
27
White matter lesions and normal-pressure hydrocephalus: Binswanger disease or Hakim syndrome? ( 1899516 )
1991
28
Subcortical arteriosclerotic encephalopathy: single photon emission computed tomography-magnetic resonance imaging correlation. ( 2252606 )
1990
29
Subcortical arteriosclerotic encephalopathy--a controlled psychometric study. ( 2548788 )
1989
30
Binswanger's disease (Part I): The clinical recognition of subcortical arteriosclerotic encephalopathy in elderly neuropsychiatric patients. ( 2686675 )
1989
31
Binswanger's disease (Part II): Pathogenesis of subcortical arteriosclerotic encephalopathy and its relation to other dementing processes. ( 2699555 )
1989
32
The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). ( 2674767 )
1989
33
Pathological findings correlated with magnetic resonance imaging in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 2614428 )
1989
34
Effects of enzymatic blood defibrination in subcortical arteriosclerotic encephalopathy. ( 3063776 )
1988
35
Cerebral amyloid angiopathy with attenuation of the white matter on CT scans: subcortical arteriosclerotic encephalopathy (Binswanger) in a normotensive patient. ( 3221249 )
1988
36
Computerized tomographic findings and differential diagnostic considerations in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3179978 )
1988
37
Subcortical arteriosclerotic encephalopathy: a clinical and radionuclide brain scintiscan study. ( 3407386 )
1988
38
Alterations of short-latency somatosensory evoked potentials in subcortical arteriosclerotic encephalopathy (Binswanger's Disease): a preliminary report. ( 3191878 )
1988
39
The corpus callosum, a unique white-matter tract: anatomic features that may explain sparing in Binswanger disease and resistance to flow of fluid masses. ( 3143229 )
1988
40
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Presentation of two cases. ( 3604757 )
1987
41
Gait disorder of subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3504256 )
1987
42
Subcortical arteriosclerotic encephalopathy: brain stem findings with MR imaging. ( 3685341 )
1987
43
High-resolution nuclear magnetic resonance imaging and single photon emission computerized tomography--cerebral blood flow in a case of pure sensory stroke and mild dementia owing to subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3502532 )
1987
44
Expanding cerebellar lacunes due to dilatation of the perivascular space associated with Binswanger's subcortical arteriosclerotic encephalopathy. ( 3686582 )
1987
45
Mental changes in subcortical arteriosclerotic encephalopathy. ( 2439247 )
1987
46
Subcortical arteriosclerotic encephalopathy: Binswanger's disease. ( 3665181 )
1987
47
The role of plasma hyperviscosity in subcortical arteriosclerotic encephalopathy (Binswanger's disease). ( 3559641 )
1987
48
Subcortical arteriosclerotic encephalopathy (Binswanger's disease): a report of five patients. ( 3618106 )
1987
49
Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Report of a case simulating psychiatric disease and normal pressure hydrocephalus. ( 3473291 )
1987
50
Subcortical arteriosclerotic encephalopathy: CT spectrum and pathologic correlation. ( 3490756 )
1986

Variations for Subcortical Arteriosclerotic Encephalopathy

Expression for Subcortical Arteriosclerotic Encephalopathy

Search GEO for disease gene expression data for Subcortical Arteriosclerotic Encephalopathy.

Pathways for Subcortical Arteriosclerotic Encephalopathy

Pathways related to Subcortical Arteriosclerotic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 GFAP VIP

GO Terms for Subcortical Arteriosclerotic Encephalopathy

Sources for Subcortical Arteriosclerotic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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