MCID: SBC025
MIFTS: 19

Subcortical Arteriosclerotic Encephalopathy

Categories: Cardiovascular diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Subcortical Arteriosclerotic Encephalopathy

MalaCards integrated aliases for Subcortical Arteriosclerotic Encephalopathy:

Name: Subcortical Arteriosclerotic Encephalopathy 53
Binswanger Disease 70

Classifications:



External Ids:

UMLS 70 C0270786

Summaries for Subcortical Arteriosclerotic Encephalopathy

NINDS : 53 Binswanger's disease (BD), also called subcortical vascular dementia, is a type of dementia caused by widespread, microscopic areas of damage to the deep layers of white matter in the brain. The damage is the result of the thickening and narrowing (atherosclerosis) of arteries that feed the subcortical areas of the brain. Atherosclerosis (commonly known as "hardening of the arteries") is a systemic process that affects blood vessels throughout the body. It begins late in the fourth decade of life and increases in severity with age. As the arteries become more and more narrowed, the blood supplied by those arteries decreases and brain tissue dies. A characteristic pattern of BD-damaged brain tissue can be seen with modern brain imaging techniques such as CT scans or magnetic resonance imaging (MRI). The symptoms associated with BD are related to the disruption of subcortical neural circuits that control what neuroscientists callexecutive cognitive functioning: short-term memory, organization, mood, the regulation of attention, the ability to act or make decisions, and appropriate behavior. The most characteristic feature of BD is psychomotor slowness - an increase in the length of time it takes, for example, for the fingers to turn the thought of a letter into the shape of a letter on a piece of paper. Other symptoms include forgetfulness (but not as severe as the forgetfulness of Alzheimer's disease), changes in speech, an unsteady gait, clumsiness or frequent falls, changes in personality or mood (most likely in the form of apathy, irritability, and depression), and urinary symptoms that aren't caused by urological disease. Brain imaging, which reveals the characteristic brain lesions of BD, is essential for a positive diagnosis.

MalaCards based summary : Subcortical Arteriosclerotic Encephalopathy, also known as binswanger disease, is related to binswanger's disease and normal pressure hydrocephalus. An important gene associated with Subcortical Arteriosclerotic Encephalopathy is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways is Neuroscience. Affiliated tissues include brain, spinal cord and smooth muscle.

Wikipedia : 73 Binswanger's disease, also known as subcortical leukoencephalopathy and subcortical arteriosclerotic... more...

Related Diseases for Subcortical Arteriosclerotic Encephalopathy

Graphical network of the top 20 diseases related to Subcortical Arteriosclerotic Encephalopathy:



Diseases related to Subcortical Arteriosclerotic Encephalopathy

Symptoms & Phenotypes for Subcortical Arteriosclerotic Encephalopathy

Drugs & Therapeutics for Subcortical Arteriosclerotic Encephalopathy

Search Clinical Trials , NIH Clinical Center for Subcortical Arteriosclerotic Encephalopathy

Genetic Tests for Subcortical Arteriosclerotic Encephalopathy

Anatomical Context for Subcortical Arteriosclerotic Encephalopathy

MalaCards organs/tissues related to Subcortical Arteriosclerotic Encephalopathy:

40
Brain, Spinal Cord, Smooth Muscle, Endothelial

Publications for Subcortical Arteriosclerotic Encephalopathy

Articles related to Subcortical Arteriosclerotic Encephalopathy:

(show top 50) (show all 163)
# Title Authors PMID Year
1
Episode of mixed mood with psychotic features secondary to Binswanger disease: a case report with a literature review. 61
33664028 2021
2
EEG Synchronization-Parameters in Patients With Subcortical Arteriosclerotic Encephalopathy and Gait Disorder. 61
32501954 2020
3
Social Cognition and White Matter: Connectivity and Cooperation. 61
32132405 2020
4
Generalized chorea associated with subcortical leukoaraiosis of Binswanger type: a case report. 61
32027572 2020
5
Current concepts on the pathophysiology of idiopathic chronic adult hydrocephalus: Are we facing another neurodegenerative disease? 61
27296497 2018
6
Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia. 61
28902409 2018
7
Validation of biomarkers in subcortical ischaemic vascular disease of the Binswanger type: approach to targeted treatment trials. 61
25618903 2015
8
Long-Term Blood-Brain Barrier Permeability Changes in Binswanger Disease. 61
26205374 2015
9
Vascular parkinsonism--characteristics, pathogenesis and treatment. 61
25917706 2015
10
Binswanger disease may benefit from omental arteries. 61
25657857 2015
11
Imaging features in conventional MRI, spectroscopy and diffusion weighted images of hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS). 61
25239393 2014
12
How far can the radiation dose be lowered in head CT with iterative reconstruction? Analysis of imaging quality and diagnostic accuracy. 61
23645331 2013
13
Impact of subcortical white matter lesions on dopamine transporter SPECT. 61
23344720 2013
14
Influence of comorbidities in idiopathic normal pressure hydrocephalus - research and clinical care. A report of the ISHCSF task force on comorbidities in INPH. 61
23758953 2013
15
[Neurourological signs of chronic cerebral vascular diseases]. 61
23994932 2013
16
Shunt surgery in patients with hydrocephalus and white matter changes. 61
21235310 2011
17
Binswanger disease--an update. 61
20875648 2010
18
Prevalence and pathology of vascular dementia in the oldest-old. 61
21504129 2010
19
Intracranial MR dynamics in clinically diagnosed Alzheimer's disease: the emerging concept of "pulse wave encephalopathy". 61
19747161 2009
20
White matter diffusion is higher in Binswanger disease than in idiopathic normal pressure hydrocephalus. 61
19485951 2009
21
Inflammation and white matter damage in vascular cognitive impairment. 61
19064797 2009
22
[Neuropathology of frontotemporal dementia]. 61
19198143 2008
23
Elevated CNS concentrations of NFL in idiopathic normal pressure hydrocephalus (INPH) and subcortical arteriosclerotic encephalopathy (SAE). 61
18307570 2008
24
CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus. 61
17922727 2007
25
Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE). 61
17340101 2007
26
Apoptosis in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy. 61
17620985 2007
27
Upregulated expression of 14-3-3 proteins in astrocytes from human cerebrovascular ischemic lesions. 61
16424378 2006
28
[Vascular parkinsonian syndrome]. 61
16133431 2006
29
Prevalence of gait disorders in hospitalized neurological patients. 61
15390043 2005
30
Vascular cognitive disorder: a new diagnostic category updating vascular cognitive impairment and vascular dementia. 61
15537526 2004
31
[Lacunar stroke and subcortical arteriosclerotic encephalopathy]. 61
15565834 2004
32
Differentiation of multiple sclerosis plaques, subacute cerebral ischaemic infarcts, focal vasogenic oedema and lesions of subcortical arteriosclerotic encephalopathy using magnetisation transfer measurements. 61
12700877 2003
33
Vascular dementia in Japan. 61
12480730 2002
34
White matter changes in normal pressure hydrocephalus and Binswanger disease: specificity, predictive value and correlations to axonal degeneration and demyelination. 61
12027829 2002
35
[A 74-year-old woman with macrocytic anemia]. 61
11963638 2002
36
[Dementia with Lewy bodies]. 61
11925777 2002
37
[Risk factors for subcortical arteriosclerotic encephalopathy]. 61
12747093 2002
38
The coagulation-fibrinolysis system in patients with leukoaraiosis and Binswanger disease. 61
11594920 2001
39
[Clinical characteristics of subcortical arteriosclerotic encephalopathy (Binswanger's disease)]. 61
11433921 2001
40
Both total and phosphorylated tau are increased in Alzheimer's disease. 61
11309456 2001
41
Leukoaraiosis three-dimensional in Binswanger disease. 61
11245711 2001
42
Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison. 61
11161160 2001
43
Psychotic depression, subcortical arteriosclerotic encephalopathy and holocaust-conditioned posttraumatic stress disorder. 61
11270447 2001
44
[Dementia with Lewy bodies]. 61
11139988 2000
45
Binswanger's disease is not a single entity. 61
11441570 2000
46
Postural disturbance in patients with normal pressure hydrocephalus. 61
11083504 2000
47
Effects of an antithrombin drug in patients with subacute exacerbations of Binswanger disease. 61
11065253 2000
48
[Binswanger disease: a common type of vascular dementia]. 61
10948585 2000
49
CSF sulfatide distinguishes between normal pressure hydrocephalus and subcortical arteriosclerotic encephalopathy. 61
10864607 2000
50
Hereditary vascular dementia linked to notch 3 mutations. CADASIL in British families. 61
10818518 2000

Variations for Subcortical Arteriosclerotic Encephalopathy

Expression for Subcortical Arteriosclerotic Encephalopathy

Search GEO for disease gene expression data for Subcortical Arteriosclerotic Encephalopathy.

Pathways for Subcortical Arteriosclerotic Encephalopathy

Pathways related to Subcortical Arteriosclerotic Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.16 VIP GFAP

GO Terms for Subcortical Arteriosclerotic Encephalopathy

Sources for Subcortical Arteriosclerotic Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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