MCID: SBC019
MIFTS: 31

Subcutaneous Mycosis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Subcutaneous Mycosis

MalaCards integrated aliases for Subcutaneous Mycosis:

Name: Subcutaneous Mycosis 12 15
Subcutaneous Fungal Disease 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050135
UMLS 71 C2242541

Summaries for Subcutaneous Mycosis

Disease Ontology : 12 A fungal infectious disease that results in infection located in skin or located in subcutaneous tissue, has material basis in Fungi, which penetrate the dermis or even deeper during or after a skin trauma.

MalaCards based summary : Subcutaneous Mycosis, also known as subcutaneous fungal disease, is related to conidiobolomycosis and chromoblastomycosis. An important gene associated with Subcutaneous Mycosis is CLEC4E (C-Type Lectin Domain Family 4 Member E), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. Affiliated tissues include skin, subcutaneous tissue and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Subcutaneous Mycosis

Diseases related to Subcutaneous Mycosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 conidiobolomycosis 31.8 EMB CBSL B4GALNT2
2 chromoblastomycosis 30.9 SYK DCLK3 CLEC7A CLEC6A CLEC4E CLEC4D
3 phaeohyphomycosis 28.1 POLR2B CLEC7A CLEC6A CLEC4E CLEC4D CBSL
4 dermatophytosis 27.1 POLR2B FLNC CLEC7A CLEC6A CLEC4E CLEC4D
5 basidiobolomycosis 11.3
6 fungal keratitis 10.3 CLEC7A CLEC4E
7 neuroaspergillosis 10.3 CLEC7A CARD9
8 amyotrophic lateral sclerosis 3 10.2 CLEC7A CCR6
9 mycobacterium abscessus 10.1 SYK CLEC7A
10 hyper ige recurrent infection syndrome 1 10.1 CLEC7A CCR6 CARD9
11 corneal ulcer 10.1 CLEC7A CLEC6A
12 tinea manuum 10.1 CBSL B4GALNT2
13 autoimmune polyendocrine syndrome type 1 10.1 CLEC7A CCR6 CARD9
14 vulvovaginal candidiasis 10.1 CLEC7A CCR6 CARD9
15 tinea nigra 10.1 POLR2B CBSL
16 tinea profunda 10.1 CLEC7A CLEC6A CLEC4E CARD9
17 pityriasis versicolor 10.0 CLEC7A CLEC6A CLEC4E CBSL
18 trichosporonosis 10.0 CLEC7A CBSL B4GALNT2
19 eumycotic mycetoma 10.0 POLR2B CBSL
20 histoplasmosis 10.0 CLEC7A CCR6
21 thrombocytopenia due to platelet alloimmunization 10.0 SYK CCR6
22 cryptococcosis 10.0 CLEC7A CLEC6A CLEC4D CCR6
23 penicilliosis 10.0 POLR2B CLEC7A CARD9
24 oral candidiasis 10.0 CLEC7A CLEC6A CCR6 CARD9
25 tinea unguium 10.0 CBSL CARD9 B4GALNT2
26 mycetoma 10.0
27 noonan syndrome 8 10.0 POLR2B CBSL
28 common wart 9.9 TLR7 CLEC6A CLEC4E
29 respiratory allergy 9.9 IL3 FLNC CCR6
30 esophageal candidiasis 9.9 FLNC CCR6 CARD9
31 sporotrichosis 9.9 EMB CLEC7A CBSL CARD9
32 cutaneous candidiasis 9.9 CLEC7A CCR6 CARD9 B4GALNT2
33 superficial mycosis 9.8 CLEC7A CLEC6A CBSL B4GALNT2
34 coccidioidomycosis 9.8 CLEC7A CLEC6A CLEC4E CCR6 CARD9
35 epidermoid cysts 9.8
36 mycosis fungoides 9.8
37 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.8
38 primary biliary cirrhosis 9.8
39 neutropenia 9.8
40 paracoccidioidomycosis 9.8
41 macroglobulinemia 9.8
42 47,xyy 9.8
43 tinea cruris 9.8 CLEC6A CBSL CARD9 B4GALNT2
44 pneumocystosis 9.8 FLNC CLEC7A CLEC6A CCR6
45 invasive aspergillosis 9.8 FLNC CLEC7A CLEC6A CCR6
46 dermatomycosis 9.8 POLR2B CBSL B4GALNT2
47 external ear disease 9.8 POLR2B CBSL B4GALNT2
48 otitis externa 9.8 POLR2B CBSL B4GALNT2
49 aspergillosis 9.8 CLEC7A CLEC1A CCR6
50 vaginal disease 9.7 TLR7 CLEC7A CCR6 CARD9

Graphical network of the top 20 diseases related to Subcutaneous Mycosis:



Diseases related to Subcutaneous Mycosis

Symptoms & Phenotypes for Subcutaneous Mycosis

MGI Mouse Phenotypes related to Subcutaneous Mycosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.65 B4GALNT2 CARD9 CBSL CCR6 CLEC4D CLEC4E
2 immune system MP:0005387 9.32 B4GALNT2 CARD9 CBSL CCR6 CLEC4D CLEC4E

Drugs & Therapeutics for Subcutaneous Mycosis

Search Clinical Trials , NIH Clinical Center for Subcutaneous Mycosis

Genetic Tests for Subcutaneous Mycosis

Anatomical Context for Subcutaneous Mycosis

The Foundational Model of Anatomy Ontology organs/tissues related to Subcutaneous Mycosis:

19
Skin, Subcutaneous Tissue

MalaCards organs/tissues related to Subcutaneous Mycosis:

40
Skin, T Cells, Lymph Node, Kidney, Pancreas, Endothelial

Publications for Subcutaneous Mycosis

Articles related to Subcutaneous Mycosis:

(show top 50) (show all 173)
# Title Authors PMID Year
1
Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11c+ Cells in Regional Lymph Nodes During Experimental Chromoblastomycosis. 61
32008205 2020
2
An optimized Agrobacterium tumefaciens-mediated transformation system for random insertional mutagenesis in Fonsecaea monophora. 61
31926179 2020
3
Antifungal activity of different molecular weight chitosans against planktonic cells and biofilm of Sporothrix brasiliensis. 61
31812752 2020
4
Proteomic analysis of Sporothrix schenckii cell wall reveals proteins involved in oxidative stress response induced by menadione. 61
31962184 2020
5
Prophylactic and therapeutic vaccines against sporotrichosis. Feasibility and prospects. 61
31201931 2019
6
Prevalence and antifungal susceptibility of Sporothrix species in Jiangxi, central China. 61
30657948 2019
7
Mild Paracoccidioidomycosis Misdiagnosed as a Subcutaneous Mycosis. 61
31209692 2019
8
Interaction with Pantoea agglomerans Modulates Growth and Melanization of Sporothrix brasiliensis and Sporothrix schenckii. 61
31214857 2019
9
[Hospitalizations and deaths related to sporotrichosis in Brazil (1992-2015)]. 61
31066776 2019
10
Exophiala psychrophila: A new agent of chromoblastomycosis. 61
30533349 2019
11
Molecular Identification and Antifungal Susceptibility of Clinical Isolates of Sporothrix schenckii Complex in Medellin, Colombia. 61
30554299 2019
12
A case of sporotrichosis caused by different Sporothrix brasiliensis strains: mycological, molecular, and virulence analyses. 61
31644705 2019
13
Sporotrichosis In Immunocompromised Hosts. 61
30641918 2019
14
Natural killer cells are pivotal for in vivo protection following systemic infection by Sporothrix schenckii. 61
30030839 2018
15
Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study. 61
30504979 2018
16
Disseminated cutaneous sporotrichosis: an unusual case. 61
30695975 2018
17
Chromoblastomycosis: clinical experience and review of literature. 61
30113072 2018
18
Sporothrix schenckii Cell Wall Proteins-Stimulated BMDCs Are Able to Induce a Th1-Prone Cytokine Profile In Vitro. 61
30200530 2018
19
Immunity and Treatment of Sporotrichosis. 61
30127270 2018
20
Fungal diseases in children and adolescents in a referral centre in Bogota, Colombia. 61
29601109 2018
21
Molecular identification and antifungal susceptibility profiles of clinical strains of Fonsecaea spp. isolated from patients with chromoblastomycosis in Rio de Janeiro, Brazil. 61
30048450 2018
22
Molecular Identification, Antifungal Susceptibility, and Geographic Origin of Clinical Strains of Sporothrix schenckii Complex in Mexico. 61
30036959 2018
23
A population genetics analysis in clinical isolates of Sporothrix schenckii based on calmodulin and calcium/calmodulin-dependent kinase partial gene sequences. 61
29394517 2018
24
Dacryocystitis due to sporothrix inoculated vis an unusual mode: Case report. 61
29924034 2018
25
Uncommon presentation of chromoblastomycosis. 61
30063772 2018
26
Melanin particles isolated from the fungus Fonsecaea pedrosoi activates the human complement system. 61
29947713 2018
27
Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to S. schenckii sensu stricto Infection in Mice. 61
29799450 2018
28
Sporotrichosis between 1898 and 2017: The evolution of knowledge on a changeable disease and on emerging etiological agents. 61
29538731 2018
29
Antifungal susceptibility of Sporothrix schenckii complex biofilms. 61
28595275 2018
30
Cell walls of the dimorphic fungal pathogens Sporothrix schenckii and Sporothrix brasiliensis exhibit bilaminate structures and sloughing of extensive and intact layers. 61
29522522 2018
31
Sporothrix schenckii Immunization, but Not Infection, Induces Protective Th17 Responses Mediated by Circulating Memory CD4+ T Cells. 61
29946313 2018
32
Subcutaneous Granulomatous Inflammation due to Basidiobolomycosis: Case Reports of 3 Patients in Buruli Ulcer Endemic Areas in Benin. 61
29545962 2018
33
Ocular sporotrichosis: A frequently misdiagnosed cause of granulomatous conjunctivitis in epidemic areas. 61
29260114 2017
34
Fungal infection control by garlic extracts (Allium sativum L.) and modulation of peritoneal macrophages activity in murine model of sporotrichosis. 61
28492800 2017
35
Disseminated cutaneous sporotrichosis in patient with alcoholism. 61
29340472 2017
36
A Challenging Case of Disseminated Subcutaneous Mycosis from Inner Rio de Janeiro State, Brazil. 61
29140239 2017
37
Subcutaneous mycoses in Peru: a systematic review and meta-analysis for the burden of disease. 61
28670680 2017
38
Comparative efficacy and toxicity of two vaccine candidates against Sporothrix schenckii using either Montanideā„¢ Pet Gel A or aluminum hydroxide adjuvants in mice. 61
28687406 2017
39
Cutaneous Nocardiosis Simulating Cutaneous Lymphatic Sporotrichosis. 61
29033815 2017
40
Subcutaneous mycosis presenting as a non- healing left calf ulcer in an immunocompromised patient. 61
28473676 2017
41
Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity. 61
28355277 2017
42
Tacrolimus Increases the Effectiveness of Itraconazole and Fluconazole against Sporothrix spp. 61
28966608 2017
43
The Major Chromoblastomycosis Etiologic Agent Fonsecaea pedrosoi Activates the NLRP3 Inflammasome. 61
29209318 2017
44
Sporothrix schenckii sensu stricto and Sporothrix brasiliensis Are Differentially Recognized by Human Peripheral Blood Mononuclear Cells. 61
28539922 2017
45
The Efficacy of Humanized Antibody against the Sporothrix Antigen, gp70, in Promoting Phagocytosis and Reducing Disease Burden. 61
28316596 2017
46
[Presence of lactoferrin (LF) in lymphocutaneous sporotrichosis. Yeast-bound antimicrobial peptide]. 61
27861481 2016
47
Clinical features of 10 cases of eyelid sporotrichosis in Jilin Province (Northeast China). 61
27521671 2016
48
Adamantylidene-substituted alkylphosphocholine TCAN26 is more active against Sporothrix schenckii than miltefosine. 61
27581121 2016
49
Osteomyelitis caused by Sporothrix schenckii in an immunocompetent patient. 61
27598646 2016
50
An Unusual Association of Adult T-Cell Leukemia/Lymphoma With Hyalohyphomycosis. 61
26981740 2016

Variations for Subcutaneous Mycosis

Expression for Subcutaneous Mycosis

Search GEO for disease gene expression data for Subcutaneous Mycosis.

Pathways for Subcutaneous Mycosis

GO Terms for Subcutaneous Mycosis

Cellular components related to Subcutaneous Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early phagosome GO:0032009 8.62 TLR7 SYK

Biological processes related to Subcutaneous Mycosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 TLR7 SYK CLEC7A CLEC6A CLEC4E CLEC4D
2 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.65 SYK CLEC7A CARD9
3 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.58 SYK CLEC7A
4 positive regulation of superoxide anion generation GO:0032930 9.57 SYK CLEC7A
5 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.56 SYK CLEC7A
6 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.55 TLR7 CLEC7A
7 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.54 SYK CLEC7A
8 pattern recognition receptor signaling pathway GO:0002221 9.52 CLEC7A CLEC4E
9 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.51 SYK CLEC7A
10 positive regulation of cytokine secretion GO:0050715 9.5 SYK CLEC6A CLEC4E
11 innate immune response GO:0045087 9.5 TLR7 SYK CLEC7A CLEC6A CLEC4E CLEC4D
12 positive regulation of killing of cells of other organism GO:0051712 9.49 SYK CLEC7A
13 cellular response to molecule of fungal origin GO:0071226 9.46 SYK CLEC7A
14 positive regulation of interleukin-10 biosynthetic process GO:0045082 9.43 SYK CLEC7A
15 Fc-gamma receptor signaling pathway GO:0038094 9.4 CLEC4E CLEC4D
16 T cell differentiation involved in immune response GO:0002292 9.37 CLEC4E CLEC4D
17 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.33 TLR7 SYK CLEC7A
18 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 SYK CLEC6A CLEC4E CLEC4D CARD9

Molecular functions related to Subcutaneous Mycosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.02 CLEC7A CLEC6A CLEC4E CLEC4D CLEC1A
2 signaling pattern recognition receptor activity GO:0008329 8.96 TLR7 CLEC7A

Sources for Subcutaneous Mycosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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