MCID: SBP002
MIFTS: 40

Subependymal Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Subependymal Glioma

MalaCards integrated aliases for Subependymal Glioma:

Name: Subependymal Glioma 12 15 17 71
Mixed Subependymoma-Ependymoma 12
Who Grade I Ependymal Tumor 12
Subependymal Astrocytoma 12
Glioma, Subependymal 43

Classifications:



External Ids:

Disease Ontology 12 DOID:4843
MeSH 43 D018315
NCIt 49 C3795
SNOMED-CT 67 4553004
UMLS 71 C0206725

Summaries for Subependymal Glioma

MalaCards based summary : Subependymal Glioma, also known as mixed subependymoma-ependymoma, is related to subependymal giant cell astrocytoma and mixed glioma, and has symptoms including headache, motor manifestations and sensory manifestations. An important gene associated with Subependymal Glioma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Signaling by GPCR and Gene Expression. The drugs Temozolomide and Etanidazole have been mentioned in the context of this disorder. Affiliated tissues include brain and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Subependymal Glioma

Diseases related to Subependymal Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 subependymal giant cell astrocytoma 29.7 TSC2 TSC1 RHEB MTOR MIR323A KCTD1
2 mixed glioma 29.4 PTEN NF1 KIAA1549
3 tuberous sclerosis 26.4 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RICTOR
4 subependymoma 11.8
5 adult hepatocellular carcinoma 10.4 TSC2 TSC1
6 hepatic angiomyolipoma 10.4 TSC2 TSC1 MTOR
7 focal cortical dysplasia, type ii 10.4 TSC2 TSC1 MTOR
8 lissencephaly with cerebellar hypoplasia 10.4 TSC2 TSC1
9 uterus perivascular epithelioid cell tumor 10.3 TSC2 TSC1 RPS6KB1
10 astrocytoma 10.3
11 glioma 10.2
12 glial tumor 10.2
13 lennox-gastaut syndrome 10.2 TSC2 TSC1 EPRS1
14 vulvar seborrheic keratosis 10.2 PTEN MTOR
15 angiomyolipoma 10.2 TSC2 TSC1 RPS6KB1 MTOR
16 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2 TSC2 TSC1 PTEN
17 lymphangioleiomyomatosis 10.2 TSC2 TSC1 RPS6KB1 MTOR
18 polycystic kidney disease 1 with or without polycystic liver disease 10.1 TSC2 TSC1 MTOR
19 aortic disease 10.1 TSC2 TSC1 RPS6KB1
20 cerebellar liponeurocytoma 10.0 KIAA1549 FAM131B
21 peutz-jeghers syndrome 10.0 TSC2 TSC1 PTEN
22 hydrocephalus 10.0
23 polycystic kidney disease 10.0 TSC2 TSC1 MTOR AKT1
24 respiratory system benign neoplasm 10.0 TSC2 PTEN AKT1
25 pilocytic astrocytoma of cerebellum 10.0 KIAA1549 FAM131B
26 uterine benign neoplasm 9.9 TSC2 PTEN AKT1
27 reproductive organ benign neoplasm 9.9 TSC2 PTEN AKT1
28 thymus gland disease 9.9 PTEN MTOR AKT1
29 thymus cancer 9.9 PTEN MTOR AKT1
30 luminal breast carcinoma 9.9 PTEN MTOR AKT1
31 connective tissue benign neoplasm 9.9 TSC2 TSC1 NF1
32 cardiovascular cancer 9.9 TSC2 NF1 MTOR
33 ocular hypertension 9.9 PTEN MTOR AKT1
34 childhood oligodendroglioma 9.8 KIAA1549 FAM131B
35 hemangioma 9.8 TSC2 PTEN MTOR AKT1
36 obstructive hydrocephalus 9.8 TSC2 TSC1 NF1 KCTD1
37 kidney benign neoplasm 9.8 TSC2 TSC1 TBC1D7 RPS6KB1 RHEB MTOR
38 renal cell carcinoma, papillary, 1 9.8 RHEB PTEN MTOR AKT1
39 ganglioglioma 9.7 TSC2 TSC1 NF1 KIAA1549
40 cell type benign neoplasm 9.7 TSC2 TSC1 PTEN MTOR AKT1
41 kidney cancer 9.7 TSC2 TSC1 PTEN MTOR AKT1
42 skin lipoma 9.7 PTEN NF1
43 suppression of tumorigenicity 12 9.7 RPS6KB1 PTEN MTOR AKT1
44 benign ependymoma 9.6 TSC2 TSC1 NF1 MTOR KCTD1
45 juvenile pilocytic astrocytoma 9.6 PTEN NF1 KIAA1549
46 acute t cell leukemia 9.6 PTEN MTOR AKT1
47 cowden syndrome 1 9.6 TSC2 TSC1 RHEB PTEN MTOR AKT1
48 pervasive developmental disorder 9.6 TSC2 TSC1 PTEN MTOR EPRS1 AKT1
49 mantle cell lymphoma 9.5 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
50 cerebellar astrocytoma 9.5 NF1 KIAA1549 FAM131B

Graphical network of the top 20 diseases related to Subependymal Glioma:



Diseases related to Subependymal Glioma

Symptoms & Phenotypes for Subependymal Glioma

UMLS symptoms related to Subependymal Glioma:


headache, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Subependymal Glioma according to GeneCards Suite gene sharing:

26 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.23 MTOR
2 Decreased viability GR00221-A-1 10.23 AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
3 Decreased viability GR00221-A-2 10.23 AKT1 NF1
4 Decreased viability GR00221-A-3 10.23 AKT1
5 Decreased viability GR00221-A-4 10.23 AKT1 MLST8 MTOR NF1
6 Decreased viability GR00301-A 10.23 RPS6KB1
7 Decreased viability GR00342-S-1 10.23 MTOR
8 Decreased viability GR00342-S-2 10.23 MTOR
9 Decreased viability GR00381-A-1 10.23 RPS6KB1
10 Decreased viability GR00402-S-2 10.23 AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.88 RICTOR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.88 MTOR RHEB
13 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.88 TSC1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.88 PTEN
15 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.88 PTEN
16 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.88 AKT1 MTOR PTEN RHEB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.88 PTEN
18 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.88 RICTOR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.88 MTOR RHEB
20 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 AKT1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-189 9.88 RICTOR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-211 9.88 RICTOR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.88 PTEN
24 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.88 AKT1 MTOR PTEN RHEB RICTOR TSC1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.88 AKT1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.88 RHEB
27 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.88 AKT1 MTOR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.88 PTEN RHEB
29 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.88 AKT1
30 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.88 MTOR
31 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.88 TSC1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.88 AKT1 MTOR
33 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.88 PTEN
34 Decreased cell migration GR00055-A-1 9.72 AKT1 MTOR NF1 RICTOR TSC1
35 Decreased viability with paclitaxel GR00179-A-1 9.35 MTOR RPS6KB1
36 Decreased viability with paclitaxel GR00179-A-2 9.35 MTOR
37 Decreased viability with paclitaxel GR00179-A-3 9.35 MTOR RPS6KB1
38 Decreased sensitivity to paclitaxel GR00112-A-0 9.26 NF1 PTEN

MGI Mouse Phenotypes related to Subependymal Glioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 AKT1 EIF4EBP1 FKBP1A KCTD1 MLST8 MTOR
2 cellular MP:0005384 10.25 AKT1 EIF4EBP1 EPRS1 FKBP1A MTOR NF1
3 embryo MP:0005380 10.22 AKT1 EPRS1 FKBP1A MLST8 MTOR NF1
4 growth/size/body region MP:0005378 10.21 AKT1 EIF4EBP1 EPRS1 FKBP1A MLST8 MTOR
5 homeostasis/metabolism MP:0005376 10.2 AKT1 AKT1S1 EIF4EBP1 EPRS1 FKBP1A KIAA1549
6 adipose tissue MP:0005375 10.13 AKT1 EIF4EBP1 EPRS1 KCTD1 MTOR PTEN
7 mortality/aging MP:0010768 10 AKT1 EIF4EBP1 EPRS1 FKBP1A MLST8 MTOR
8 liver/biliary system MP:0005370 9.86 AKT1 FKBP1A NF1 PTEN RICTOR RPTOR
9 muscle MP:0005369 9.7 AKT1 EIF4EBP1 FKBP1A MTOR NF1 PTEN
10 neoplasm MP:0002006 9.17 AKT1 NF1 PTEN RICTOR RPS6KB1 TSC1

Drugs & Therapeutics for Subependymal Glioma

Drugs for Subependymal Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
2
Etanidazole Investigational Phase 1 22668-01-5
3 Liver Extracts Phase 1
4 Protein Kinase Inhibitors Phase 1
5
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
6 Alkylating Agents Phase 1
7 Protective Agents Phase 1
8 Fluorides Phase 1
9 Cariostatic Agents Phase 1
10
Dopamine Approved Early Phase 1 51-61-6, 62-31-7 681
11
Imidazole Experimental, Investigational 288-32-4 795
12 Neurotransmitter Agents Early Phase 1
13 Dopamine Agents Early Phase 1
14 Dihydroxyphenylalanine Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
2 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
3 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
4 A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors Active, not recruiting NCT01165632 Early Phase 1 fluorine F 18 fluorodopa
5 Assessment of Hypoxia in Malignant Gliomas Using EF5 Terminated NCT00430079 etanidazole
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Subependymal Glioma

Cochrane evidence based reviews: glioma, subependymal

Genetic Tests for Subependymal Glioma

Anatomical Context for Subependymal Glioma

MalaCards organs/tissues related to Subependymal Glioma:

40
Brain, Liver

Publications for Subependymal Glioma

Articles related to Subependymal Glioma:

# Title Authors PMID Year
1
Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. 61
30467464 2018
2
AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. 61
18957620 2009
3
[Histogenesis of subependymal glioma in Bourneville's tuberous sclerosis]. 61
2346568 1990
4
Long-term neurological sequelae in achondroplasia. 61
6510432 1984
5
[Experimental brain tumors produced transplacentally by ethylnitrosourea (IV): ultrastructure studied by using transmission and scanning electron microscope (author's transl)]. 61
708510 1978
6
PAPILLARY SUBEPENDYMAL GLIOSIS (GLIOMATOSIS) ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE AND SUBEPENDYMAL GLIOMA. 61
14063111 1963
7
Subependymal glioma with hypertension: diagnostic problem. 61
14371747 1955

Variations for Subependymal Glioma

Expression for Subependymal Glioma

Search GEO for disease gene expression data for Subependymal Glioma.

Pathways for Subependymal Glioma

Pathways related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.25 TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
2
Show member pathways
13.9 TSC2 TSC1 RPTOR RICTOR RHEB PTEN
3
Show member pathways
13.8 TSC2 RICTOR NF1 MTOR MLST8 KIAA1549
4
Show member pathways
13.65 TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
5
Show member pathways
13.49 TSC2 TSC1 RPS6KB1 PTEN MTOR EIF4EBP1
6
Show member pathways
13.22 TSC2 TSC1 RPTOR RHEB MTOR MLST8
7
Show member pathways
13.2 TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
8
Show member pathways
13.2 TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
9
Show member pathways
13.13 TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
10
Show member pathways
13.1 TSC2 TSC1 RPTOR RICTOR RHEB PTEN
11
Show member pathways
13.05 TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
12
Show member pathways
13.04 TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
13
Show member pathways
13.01 TSC2 RPS6KB1 RHEB PTEN MTOR AKT1
14
Show member pathways
12.98 TSC2 RPS6KB1 RHEB PTEN MTOR EIF4EBP1
15 12.89 TSC2 TSC1 RHEB MTOR EIF4EBP1 AKT1
16
Show member pathways
12.86 TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
17
Show member pathways
12.85 RPTOR PTEN MTOR MLST8 EIF4EBP1 AKT1S1
18
Show member pathways
12.81 TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
19
Show member pathways
12.73 RPS6KB1 PTEN NF1 MTOR EIF4EBP1 AKT1
20
Show member pathways
12.72 TSC2 RPS6KB1 RHEB MTOR AKT1
21
Show member pathways
12.63 TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
22
Show member pathways
12.6 TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
23
Show member pathways
12.58 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
24
Show member pathways
12.57 TSC2 TSC1 RPS6KB1 RHEB PTEN MTOR
25
Show member pathways
12.56 TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
26 12.48 RPTOR RPS6KB1 MTOR AKT1S1 AKT1
27 12.45 TSC2 TSC1 RPTOR RPS6KB1 RICTOR MTOR
28
Show member pathways
12.44 RPS6KB1 PTEN MTOR AKT1S1 AKT1
29
Show member pathways
12.44 TSC2 TSC1 RPS6KB1 MTOR EIF4EBP1 AKT1
30
Show member pathways
12.39 RPS6KB1 MTOR EIF4EBP1 AKT1
31
Show member pathways
12.39 TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
32 12.35 RPS6KB1 RICTOR PTEN MTOR EIF4EBP1 AKT1
33 12.35 TSC2 TSC1 RHEB PTEN MTOR EIF4EBP1
34
Show member pathways
12.33 TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
35 12.32 TSC2 TSC1 RHEB PTEN NF1 MTOR
36
Show member pathways
12.3 TSC2 TSC1 RPTOR RHEB MTOR MLST8
37
Show member pathways
12.29 TSC2 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
38
Show member pathways
12.29 TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
39
Show member pathways
12.28 RICTOR MTOR MLST8 AKT1
40
Show member pathways
12.28 RPTOR MTOR MLST8 AKT1S1
41 12.24 TSC2 RPS6KB1 MTOR EIF4EBP1 AKT1
42
Show member pathways
12.16 TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
43 12.16 TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
44 12.16 TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
45
Show member pathways
12.14 RPS6KB1 MTOR EIF4EBP1 AKT1
46 12.1 TSC2 RHEB MTOR AKT1
47
Show member pathways
12.06 RPS6KB1 PTEN MTOR AKT1
48 12.06 RPS6KB1 MTOR EIF4EBP1 AKT1
49 12.06 TSC2 TSC1 TBC1D7 RHEB PTEN AKT1S1
50 12.04 PTEN MTOR MLST8 AKT1S1

GO Terms for Subependymal Glioma

Cellular components related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.21 TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
2 cytosol GO:0005829 9.91 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RICTOR
3 postsynaptic cytosol GO:0099524 9.43 PTEN MTOR EIF4EBP1
4 TORC2 complex GO:0031932 9.33 RICTOR MTOR MLST8
5 TSC1-TSC2 complex GO:0033596 9.32 TSC2 TSC1
6 TORC1 complex GO:0031931 8.92 RPTOR MTOR MLST8 AKT1S1

Biological processes related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-serine phosphorylation GO:0018105 9.91 RPS6KB1 RICTOR MTOR AKT1
2 cell cycle arrest GO:0007050 9.9 RPTOR RHEB MTOR MLST8
3 cellular response to hypoxia GO:0071456 9.88 PTEN MTOR EIF4EBP1 AKT1
4 cellular response to insulin stimulus GO:0032869 9.86 RPS6KB1 PTEN EPRS1 AKT1
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 RICTOR MTOR MLST8
6 regulation of GTPase activity GO:0043087 9.85 RICTOR NF1 MTOR MLST8
7 regulation of translation GO:0006417 9.85 TSC1 RPS6KB1 EPRS1 EIF4EBP1 AKT1
8 negative regulation of protein kinase activity GO:0006469 9.84 TSC2 NF1 AKT1S1 AKT1
9 response to nutrient GO:0007584 9.83 RPS6KB1 PTEN MTOR
10 negative regulation of translation GO:0017148 9.83 TSC1 EPRS1 EIF4EBP1
11 regulation of actin cytoskeleton organization GO:0032956 9.83 RICTOR MTOR MLST8
12 regulation of cellular response to heat GO:1900034 9.83 RPTOR MTOR MLST8 AKT1S1
13 regulation of macroautophagy GO:0016241 9.81 RPTOR RHEB MTOR MLST8
14 negative regulation of protein kinase B signaling GO:0051898 9.8 TSC2 PTEN AKT1
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 RPS6KB1 MTOR AKT1
16 positive regulation of actin filament polymerization GO:0030838 9.79 RICTOR MTOR MLST8
17 germ cell development GO:0007281 9.77 RPS6KB1 MTOR AKT1
18 negative regulation of insulin receptor signaling pathway GO:0046627 9.75 TSC2 TSC1 RPS6KB1
19 spinal cord development GO:0021510 9.74 NF1 MTOR AKT1
20 protein kinase B signaling GO:0043491 9.73 TSC2 RPS6KB1 PTEN AKT1
21 activation of protein kinase B activity GO:0032148 9.71 RICTOR MTOR MLST8 AKT1
22 regulation of protein kinase B signaling GO:0051896 9.68 RICTOR MTOR
23 insulin-like growth factor receptor signaling pathway GO:0048009 9.68 TSC2 AKT1
24 regulation of synaptic transmission, GABAergic GO:0032228 9.68 PTEN NF1
25 cellular response to nutrient levels GO:0031669 9.67 RPTOR MTOR
26 positive regulation of lipid biosynthetic process GO:0046889 9.67 MTOR AKT1
27 negative regulation of macroautophagy GO:0016242 9.67 TSC1 MTOR AKT1
28 regulation of cell-matrix adhesion GO:0001952 9.66 TSC1 NF1
29 cellular response to leucine GO:0071233 9.65 RPTOR MTOR
30 anoikis GO:0043276 9.65 TSC2 MTOR AKT1
31 positive regulation of transcription by RNA polymerase III GO:0045945 9.64 RPTOR MTOR
32 forebrain morphogenesis GO:0048853 9.64 PTEN NF1
33 regulation of glycogen biosynthetic process GO:0005979 9.63 MTOR AKT1
34 positive regulation of TOR signaling GO:0032008 9.62 RPTOR RICTOR RHEB MLST8
35 cellular response to decreased oxygen levels GO:0036294 9.61 PTEN AKT1
36 negative regulation of TOR signaling GO:0032007 9.56 TSC2 TSC1 TBC1D7 AKT1S1
37 positive regulation of endothelial cell proliferation GO:0001938 9.55 RPTOR RICTOR NF1 MTOR AKT1
38 TORC1 signaling GO:0038202 9.54 RPTOR MTOR MLST8
39 negative regulation of cell size GO:0045792 9.35 TSC1 PTEN MTOR AKT1S1 AKT1
40 TOR signaling GO:0031929 9.17 RPTOR RPS6KB1 RICTOR MTOR MLST8 EIF4EBP1

Molecular functions related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RICTOR
2 protein phosphatase 2A binding GO:0051721 9.5 RPS6KB1 EIF4EBP1 AKT1
3 RNA polymerase III type 3 promoter DNA binding GO:0001032 9.37 RPTOR MTOR
4 TFIIIC-class transcription factor complex binding GO:0001156 9.26 RPTOR MTOR
5 RNA polymerase III type 2 promoter DNA binding GO:0001031 9.16 RPTOR MTOR
6 protein kinase binding GO:0019901 9.1 RPTOR RICTOR RHEB PTEN MTOR AKT1
7 RNA polymerase III type 1 promoter DNA binding GO:0001030 8.96 RPTOR MTOR

Sources for Subependymal Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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