MCID: SBP002
MIFTS: 40

Subependymal Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Subependymal Glioma

MalaCards integrated aliases for Subependymal Glioma:

Name: Subependymal Glioma 12 15 17 71
Mixed Subependymoma-Ependymoma 12
Who Grade I Ependymal Tumor 12
Subependymal Astrocytoma 12
Glioma, Subependymal 43

Classifications:



External Ids:

Disease Ontology 12 DOID:4843
MeSH 43 D018315
NCIt 49 C3795
SNOMED-CT 67 4553004
UMLS 71 C0206725

Summaries for Subependymal Glioma

MalaCards based summary : Subependymal Glioma, also known as mixed subependymoma-ependymoma, is related to subependymal giant cell astrocytoma and tuberous sclerosis, and has symptoms including headache, motor manifestations and sensory manifestations. An important gene associated with Subependymal Glioma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Signaling by GPCR and Gene Expression. The drugs Temozolomide and Etanidazole have been mentioned in the context of this disorder. Affiliated tissues include brain and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Subependymal Glioma

Diseases related to Subependymal Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 subependymal giant cell astrocytoma 29.5 TSC2 TSC1 RHEB MTOR MIR323A FKBP1A
2 tuberous sclerosis 26.7 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3 subependymoma 11.8
4 angiomyolipoma 10.4 TSC2 TSC1 MTOR
5 lissencephaly with cerebellar hypoplasia 10.4 TSC2 TSC1
6 heart cancer 10.4 TSC2 TSC1 MTOR
7 focal cortical dysplasia, type ii 10.4 TSC2 TSC1 MTOR
8 vulvar seborrheic keratosis 10.4 PTEN MTOR
9 uterus perivascular epithelioid cell tumor 10.4 TSC2 TSC1 RPS6KB1
10 hepatic angiomyolipoma 10.4 TSC2 MTOR
11 exudative vitreoretinopathy 6 10.4 MTOR FKBP1A
12 scalp-ear-nipple syndrome 10.3 TSC2 TSC1 TBC1D7
13 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3 TSC2 TSC1 PTEN
14 birt-hogg-dube syndrome 10.3 TSC2 PTEN MTOR
15 kidney benign neoplasm 10.3 TSC2 TSC1 RHEB MTOR
16 astrocytoma 10.3
17 glioma 10.2
18 glial tumor 10.2
19 epilepsy, idiopathic generalized 3 10.2 MLST8 EPRS1
20 peutz-jeghers syndrome 10.2 TSC2 TSC1 PTEN
21 polycystic kidney disease 1 with or without polycystic liver disease 10.2 TSC2 TSC1 MTOR
22 uterine benign neoplasm 10.1 TSC2 PTEN AKT1
23 reproductive organ benign neoplasm 10.1 TSC2 PTEN AKT1
24 thymus gland disease 10.1 PTEN MTOR AKT1
25 cystic kidney disease 10.1 TSC2 TSC1 MTOR AKT1
26 optic nerve astrocytoma 10.1 TSC2 NF1
27 neurofibromatosis, type i 10.1 TSC2 TSC1 NF1
28 thymus cancer 10.1 PTEN MTOR AKT1
29 connective tissue benign neoplasm 10.1 TSC2 TSC1 NF1
30 cardiovascular cancer 10.1 TSC2 NF1 MTOR
31 ocular hypertension 10.1 PTEN MTOR AKT1
32 polycystic kidney disease 10.1 TSC2 TSC1 MTOR AKT1
33 corneal dystrophy, fleck 10.0 TSC2 TSC1 MTOR DEPDC5
34 lennox-gastaut syndrome 10.0 TSC2 TSC1 EPRS1 DEPDC5
35 mixed glioma 10.0
36 cell type benign neoplasm 10.0 TSC2 PTEN MTOR AKT1
37 focal epilepsy 10.0 TSC2 TSC1 MTOR DEPDC5
38 pilocytic astrocytoma of cerebellum 10.0 NF1 KIAA1549
39 breast juvenile papillomatosis 10.0 NF1 AKT1
40 hemangioma 10.0 TSC2 PTEN MTOR AKT1
41 palmoplantar keratoderma, bothnian type 10.0 RPS6KB1 PTEN MTOR AKT1
42 renal cell carcinoma, papillary, 1 10.0 RHEB PTEN MTOR AKT1
43 optic nerve neoplasm 9.9 NF1 KIAA1549
44 early infantile epileptic encephalopathy 9.9 TSC2 TSC1 EPRS1 DEPDC5
45 lymphangioleiomyomatosis 9.9 TSC2 TSC1 RPS6KB1 RPS6 MTOR
46 suppression of tumorigenicity 12 9.9 RPS6KB1 PTEN MTOR AKT1
47 ganglioglioma 9.9 TSC2 TSC1 NF1 KIAA1549
48 fibrillary astrocytoma 9.9 PTEN NF1 KIAA1549
49 kidney cancer 9.9 TSC2 TSC1 PTEN MTOR AKT1
50 obstructive hydrocephalus 9.9 TSC2 TSC1 RICTOR NF1

Graphical network of the top 20 diseases related to Subependymal Glioma:



Diseases related to Subependymal Glioma

Symptoms & Phenotypes for Subependymal Glioma

UMLS symptoms related to Subependymal Glioma:


headache, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Subependymal Glioma according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 10.37 MTOR RHEB
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 10.37 TSC1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 10.37 PTEN
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 10.37 AKT1 MTOR RHEB
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 10.37 RICTOR
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 10.37 MTOR RHEB
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 10.37 AKT1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 10.37 TSC1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 10.37 TSC1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 10.37 RHEB
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 10.37 TSC1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 10.37 AKT1 MTOR RHEB RICTOR
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 10.37 AKT1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 10.37 MTOR
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-57 10.37 RHEB
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 10.37 RHEB
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 10.37 MTOR
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 10.37 AKT1
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-82 10.37 TSC1
20 Decreased viability GR00055-A-1 10.23 MTOR
21 Decreased viability GR00055-A-2 10.23 MTOR
22 Decreased viability GR00221-A-1 10.23 AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
23 Decreased viability GR00221-A-2 10.23 AKT1 NF1
24 Decreased viability GR00221-A-3 10.23 AKT1
25 Decreased viability GR00221-A-4 10.23 AKT1 MLST8 MTOR NF1
26 Decreased viability GR00249-S 10.23 AKT1 NF1
27 Decreased viability GR00301-A 10.23 RPS6KB1
28 Decreased viability GR00342-S-1 10.23 MTOR
29 Decreased viability GR00342-S-2 10.23 MTOR
30 Decreased viability GR00381-A-1 10.23 RPS6KB1
31 Decreased viability GR00386-A-1 10.23 NF1 RHEB
32 Decreased viability GR00402-S-2 10.23 RPS6KB1
33 Decreased cell migration GR00055-A-1 9.77 AKT1 RICTOR TSC1
34 Decreased cell migration GR00055-A-3 9.77 MTOR RICTOR
35 Decreased viability with paclitaxel GR00179-A-1 9.35 MTOR RPS6KB1
36 Decreased viability with paclitaxel GR00179-A-2 9.35 MTOR
37 Decreased viability with paclitaxel GR00179-A-3 9.35 MTOR RPS6KB1
38 Decreased sensitivity to paclitaxel GR00112-A-0 9.32 NF1 PTEN
39 Reduced mammosphere formation GR00396-S 9.17 AKT1S1 EIF4EBP1 MTOR PTEN RHEB RPS6

MGI Mouse Phenotypes related to Subependymal Glioma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.34 AKT1 EIF4EBP1 EPRS1 FKBP1A MTOR NF1
2 growth/size/body region MP:0005378 10.34 AKT1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A MLST8
3 homeostasis/metabolism MP:0005376 10.33 AKT1 AKT1S1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A
4 cardiovascular system MP:0005385 10.29 AKT1 EIF4EBP1 FKBP1A MLST8 MTOR NF1
5 embryo MP:0005380 10.29 AKT1 EPRS1 FKBP1A MLST8 MTOR NF1
6 mortality/aging MP:0010768 10.2 AKT1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A MLST8
7 adipose tissue MP:0005375 10.13 AKT1 EIF4EBP1 EPRS1 MTOR PTEN RICTOR
8 endocrine/exocrine gland MP:0005379 10.11 AKT1 MTOR NF1 PTEN RICTOR RPS6
9 liver/biliary system MP:0005370 10.02 AKT1 FKBP1A NF1 PTEN RICTOR RPS6
10 muscle MP:0005369 10 AKT1 EIF4EBP1 FKBP1A MTOR NF1 PTEN
11 neoplasm MP:0002006 9.7 AKT1 NF1 PTEN RICTOR RPS6KB1 TSC1
12 nervous system MP:0003631 9.7 AKT1 AKT1S1 DEPDC5 FKBP1A MLST8 MTOR
13 skeleton MP:0005390 9.28 AKT1 DEPDC5 EPRS1 MTOR NF1 PTEN

Drugs & Therapeutics for Subependymal Glioma

Drugs for Subependymal Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
2
Etanidazole Investigational Phase 1 22668-01-5
3 Protein Kinase Inhibitors Phase 1
4
Erlotinib Hydrochloride Phase 1 183319-69-9 176871
5 Liver Extracts Phase 1
6 Alkylating Agents Phase 1
7 Fluorides Phase 1
8
Dopamine Approved Early Phase 1 51-61-6, 62-31-7 681
9
Imidazole Experimental, Investigational 288-32-4 795
10 Neurotransmitter Agents Early Phase 1
11 Dihydroxyphenylalanine Early Phase 1
12 Dopamine Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
2 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
3 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
4 A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors Active, not recruiting NCT01165632 Early Phase 1 fluorine F 18 fluorodopa
5 Assessment of Hypoxia in Malignant Gliomas Using EF5 Terminated NCT00430079 etanidazole
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Subependymal Glioma

Cochrane evidence based reviews: glioma, subependymal

Genetic Tests for Subependymal Glioma

Anatomical Context for Subependymal Glioma

MalaCards organs/tissues related to Subependymal Glioma:

40
Brain, Liver

Publications for Subependymal Glioma

Articles related to Subependymal Glioma:

# Title Authors PMID Year
1
Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. 61
30467464 2018
2
AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. 61
18957620 2009
3
[Histogenesis of subependymal glioma in Bourneville's tuberous sclerosis]. 61
2346568 1990
4
Long-term neurological sequelae in achondroplasia. 61
6510432 1984
5
[Experimental brain tumors produced transplacentally by ethylnitrosourea (IV): ultrastructure studied by using transmission and scanning electron microscope (author's transl)]. 61
708510 1978
6
PAPILLARY SUBEPENDYMAL GLIOSIS (GLIOMATOSIS) ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE AND SUBEPENDYMAL GLIOMA. 61
14063111 1963
7
Subependymal glioma with hypertension: diagnostic problem. 61
14371747 1955

Variations for Subependymal Glioma

Expression for Subependymal Glioma

Search GEO for disease gene expression data for Subependymal Glioma.

Pathways for Subependymal Glioma

Pathways related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.27 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
2
Show member pathways
13.92 TSC2 TSC1 RPTOR RPS6 RICTOR RHEB
3
Show member pathways
13.8 TSC2 RPS6 RICTOR NF1 MTOR MLST8
4
Show member pathways
13.49 TSC2 TSC1 RPS6KB1 PTEN MTOR EIF4EBP1
5
Show member pathways
13.42 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
6
Show member pathways
13.23 TSC2 TSC1 RPTOR RHEB MTOR MLST8
7
Show member pathways
13.21 TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
8
Show member pathways
13.21 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
9
Show member pathways
13.15 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
10
Show member pathways
13.12 TSC2 RPS6KB1 RHEB PTEN MTOR AKT1
11
Show member pathways
13.11 TSC2 TSC1 RPTOR RICTOR RHEB PTEN
12
Show member pathways
13.08 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
13
Show member pathways
13.06 TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
14
Show member pathways
13 TSC2 RPS6KB1 RHEB PTEN MTOR EIF4EBP1
15
Show member pathways
12.9 RPS6KB1 RPS6 PTEN MTOR AKT1
16 12.9 TSC2 TSC1 RHEB MTOR EIF4EBP1 AKT1
17
Show member pathways
12.87 TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
18
Show member pathways
12.86 RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
19
Show member pathways
12.86 RPTOR PTEN MTOR MLST8 EIF4EBP1 AKT1S1
20
Show member pathways
12.84 RPS6KB1 RPS6 PTEN MTOR AKT1
21
Show member pathways
12.81 TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
22
Show member pathways
12.76 RPS6KB1 RPS6 PTEN NF1 MTOR EIF4EBP1
23
Show member pathways
12.73 TSC2 RPS6KB1 RHEB MTOR AKT1
24
Show member pathways
12.69 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
25
Show member pathways
12.63 RPS6KB1 RPS6 PTEN MTOR EIF4EBP1 AKT1
26
Show member pathways
12.63 TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
27
Show member pathways
12.6 RPTOR RPS6KB1 PTEN MTOR AKT1S1 AKT1
28
Show member pathways
12.59 TSC2 TSC1 RPS6KB1 RPS6 RHEB PTEN
29
Show member pathways
12.57 TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
30 12.51 RPTOR RPS6KB1 MTOR AKT1S1 AKT1
31
Show member pathways
12.46 TSC2 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
32 12.42 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
33
Show member pathways
12.4 RPS6KB1 MTOR EIF4EBP1 AKT1
34
Show member pathways
12.4 TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
35
Show member pathways
12.38 RPS6 RICTOR MTOR AKT1
36 12.37 RPS6KB1 RPS6 MTOR AKT1
37
Show member pathways
12.37 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
38 12.35 RPS6KB1 RICTOR PTEN MTOR EIF4EBP1 AKT1
39 12.35 TSC2 TSC1 RHEB PTEN MTOR EIF4EBP1
40 12.34 RPTOR MTOR MLST8 AKT1S1
41 12.34 TSC2 TSC1 RHEB PTEN NF1 MTOR
42
Show member pathways
12.33 TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
43
Show member pathways
12.29 RICTOR MTOR MLST8 AKT1
44
Show member pathways
12.29 RPTOR MTOR MLST8 AKT1S1
45 12.28 TSC2 RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
46
Show member pathways
12.26 RPS6KB1 RPS6 PTEN AKT1
47 12.18 RPS6KB1 RPS6 MTOR AKT1
48 12.18 TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
49
Show member pathways
12.17 TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
50
Show member pathways
12.16 RPS6KB1 MTOR EIF4EBP1 AKT1

GO Terms for Subependymal Glioma

Cellular components related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.24 TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
2 cytosol GO:0005829 9.58 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3 postsynaptic cytosol GO:0099524 9.43 PTEN MTOR EIF4EBP1
4 TORC2 complex GO:0031932 9.33 RICTOR MTOR MLST8
5 TSC1-TSC2 complex GO:0033596 9.32 TSC2 TSC1
6 TORC1 complex GO:0031931 9.26 RPTOR MTOR MLST8 AKT1S1

Biological processes related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-serine phosphorylation GO:0018105 9.92 RPS6KB1 RICTOR MTOR AKT1
2 cell cycle arrest GO:0007050 9.89 RPTOR RHEB MTOR MLST8
3 cellular response to hypoxia GO:0071456 9.88 PTEN MTOR EIF4EBP1 AKT1
4 cellular response to insulin stimulus GO:0032869 9.86 RPS6KB1 PTEN EPRS1 AKT1
5 regulation of GTPase activity GO:0043087 9.85 RICTOR NF1 MTOR MLST8
6 regulation of translation GO:0006417 9.85 TSC1 RPS6KB1 EPRS1 EIF4EBP1 AKT1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.84 RICTOR MTOR MLST8
8 negative regulation of protein kinase activity GO:0006469 9.84 TSC2 NF1 AKT1S1 AKT1
9 negative regulation of translation GO:0017148 9.83 TSC1 EPRS1 EIF4EBP1
10 regulation of actin cytoskeleton organization GO:0032956 9.83 RICTOR MTOR MLST8
11 regulation of autophagy GO:0010506 9.82 RPTOR MTOR DEPDC5
12 regulation of cellular response to heat GO:1900034 9.81 RPTOR MTOR MLST8 AKT1S1
13 negative regulation of protein kinase B signaling GO:0051898 9.8 TSC2 PTEN AKT1
14 positive regulation of actin filament polymerization GO:0030838 9.8 RICTOR MTOR MLST8
15 regulation of macroautophagy GO:0016241 9.8 RPTOR RHEB MTOR MLST8
16 protein kinase B signaling GO:0043491 9.78 TSC2 PTEN AKT1
17 phosphatidylinositol 3-kinase signaling GO:0014065 9.77 PTEN NF1 AKT1
18 negative regulation of insulin receptor signaling pathway GO:0046627 9.75 TSC2 TSC1 RPS6KB1
19 spinal cord development GO:0021510 9.74 NF1 MTOR AKT1
20 regulation of protein kinase B signaling GO:0051896 9.7 RICTOR PTEN MTOR
21 positive regulation of lipid biosynthetic process GO:0046889 9.68 MTOR AKT1
22 regulation of synaptic transmission, GABAergic GO:0032228 9.68 PTEN NF1
23 insulin-like growth factor receptor signaling pathway GO:0048009 9.67 TSC2 AKT1
24 cellular response to nutrient levels GO:0031669 9.67 RPTOR MTOR
25 positive regulation of TOR signaling GO:0032008 9.67 RPTOR RICTOR RHEB MLST8
26 regulation of cell-matrix adhesion GO:0001952 9.66 TSC1 NF1
27 regulation of glycogen biosynthetic process GO:0005979 9.66 MTOR AKT1
28 negative regulation of macroautophagy GO:0016242 9.65 TSC1 MTOR AKT1
29 positive regulation of endothelial cell proliferation GO:0001938 9.65 RPTOR RICTOR NF1 MTOR AKT1
30 cellular response to leucine GO:0071233 9.64 RPTOR MTOR
31 positive regulation of transcription by RNA polymerase III GO:0045945 9.64 RPTOR MTOR
32 forebrain morphogenesis GO:0048853 9.63 PTEN NF1
33 activation of protein kinase B activity GO:0032148 9.62 RICTOR MTOR MLST8 AKT1
34 cellular response to decreased oxygen levels GO:0036294 9.61 PTEN AKT1
35 anoikis GO:0043276 9.61 TSC2 MTOR AKT1
36 TORC1 signaling GO:0038202 9.58 RPTOR MTOR MLST8
37 negative regulation of TOR signaling GO:0032007 9.55 TSC2 TSC1 TBC1D7 DEPDC5 AKT1S1
38 negative regulation of cell size GO:0045792 9.35 TSC1 PTEN MTOR AKT1S1 AKT1
39 TOR signaling GO:0031929 9.23 RPTOR RPS6KB1 RPS6 RICTOR MTOR MLST8

Molecular functions related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activator activity GO:0005096 9.76 TSC2 TBC1D7 NF1 DEPDC5
2 GTPase activating protein binding GO:0032794 9.48 TSC1 AKT1
3 RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006 9.43 RPTOR MTOR
4 RNA polymerase III type 3 promoter DNA binding GO:0001032 9.4 RPTOR MTOR
5 RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0001003 9.37 RPTOR MTOR
6 RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001002 9.32 RPTOR MTOR
7 TFIIIC-class transcription factor complex binding GO:0001156 9.26 RPTOR MTOR
8 protein kinase binding GO:0019901 9.17 RPTOR RPS6 RICTOR RHEB PTEN MTOR
9 RNA polymerase III type 2 promoter DNA binding GO:0001031 9.16 RPTOR MTOR
10 RNA polymerase III type 1 promoter DNA binding GO:0001030 8.96 RPTOR MTOR

Sources for Subependymal Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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