Subependymal Glioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: SBP002 MIFTS: 40	Subependymal Glioma Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Subependymal Glioma

MalaCards integrated aliases for Subependymal Glioma:

Name: Subependymal Glioma ¹² ¹⁵ ¹⁷ ⁷¹

Mixed Subependymoma-Ependymoma ¹²

Who Grade I Ependymal Tumor ¹²

Subependymal Astrocytoma ¹²

Glioma, Subependymal ⁴³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4843

MeSH ⁴³ D018315

NCIt ⁴⁹ C3795

SNOMED-CT ⁶⁷ 4553004

EFO ¹⁷ EFO_1001197

UMLS ⁷¹ C0206725

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Summaries for Subependymal Glioma

MalaCards based summary : Subependymal Glioma, also known as mixed subependymoma-ependymoma, is related to subependymal giant cell astrocytoma and tuberous sclerosis, and has symptoms including headache, motor manifestations and sensory manifestations. An important gene associated with Subependymal Glioma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Signaling by GPCR and Gene Expression. The drugs Temozolomide and Etanidazole have been mentioned in the context of this disorder. Affiliated tissues include brain and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Subependymal Glioma

Diseases related to Subependymal Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)

#	Related Disease	Score	Top Affiliating Genes
1	subependymal giant cell astrocytoma	29.5	TSC2 TSC1 RHEB MTOR MIR323A FKBP1A
2	tuberous sclerosis	26.7	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3	subependymoma	11.8
4	angiomyolipoma	10.4	TSC2 TSC1 MTOR
5	lissencephaly with cerebellar hypoplasia	10.4	TSC2 TSC1
6	heart cancer	10.4	TSC2 TSC1 MTOR
7	focal cortical dysplasia, type ii	10.4	TSC2 TSC1 MTOR
8	vulvar seborrheic keratosis	10.4	PTEN MTOR
9	uterus perivascular epithelioid cell tumor	10.4	TSC2 TSC1 RPS6KB1
10	hepatic angiomyolipoma	10.4	TSC2 MTOR
11	exudative vitreoretinopathy 6	10.4	MTOR FKBP1A
12	scalp-ear-nipple syndrome	10.3	TSC2 TSC1 TBC1D7
13	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.3	TSC2 TSC1 PTEN
14	birt-hogg-dube syndrome	10.3	TSC2 PTEN MTOR
15	kidney benign neoplasm	10.3	TSC2 TSC1 RHEB MTOR
16	astrocytoma	10.3
17	glioma	10.2
18	glial tumor	10.2
19	epilepsy, idiopathic generalized 3	10.2	MLST8 EPRS1
20	peutz-jeghers syndrome	10.2	TSC2 TSC1 PTEN
21	polycystic kidney disease 1 with or without polycystic liver disease	10.2	TSC2 TSC1 MTOR
22	uterine benign neoplasm	10.1	TSC2 PTEN AKT1
23	reproductive organ benign neoplasm	10.1	TSC2 PTEN AKT1
24	thymus gland disease	10.1	PTEN MTOR AKT1
25	cystic kidney disease	10.1	TSC2 TSC1 MTOR AKT1
26	optic nerve astrocytoma	10.1	TSC2 NF1
27	neurofibromatosis, type i	10.1	TSC2 TSC1 NF1
28	thymus cancer	10.1	PTEN MTOR AKT1
29	connective tissue benign neoplasm	10.1	TSC2 TSC1 NF1
30	cardiovascular cancer	10.1	TSC2 NF1 MTOR
31	ocular hypertension	10.1	PTEN MTOR AKT1
32	polycystic kidney disease	10.1	TSC2 TSC1 MTOR AKT1
33	corneal dystrophy, fleck	10.0	TSC2 TSC1 MTOR DEPDC5
34	lennox-gastaut syndrome	10.0	TSC2 TSC1 EPRS1 DEPDC5
35	mixed glioma	10.0
36	cell type benign neoplasm	10.0	TSC2 PTEN MTOR AKT1
37	focal epilepsy	10.0	TSC2 TSC1 MTOR DEPDC5
38	pilocytic astrocytoma of cerebellum	10.0	NF1 KIAA1549
39	breast juvenile papillomatosis	10.0	NF1 AKT1
40	hemangioma	10.0	TSC2 PTEN MTOR AKT1
41	palmoplantar keratoderma, bothnian type	10.0	RPS6KB1 PTEN MTOR AKT1
42	renal cell carcinoma, papillary, 1	10.0	RHEB PTEN MTOR AKT1
43	optic nerve neoplasm	9.9	NF1 KIAA1549
44	early infantile epileptic encephalopathy	9.9	TSC2 TSC1 EPRS1 DEPDC5
45	lymphangioleiomyomatosis	9.9	TSC2 TSC1 RPS6KB1 RPS6 MTOR
46	suppression of tumorigenicity 12	9.9	RPS6KB1 PTEN MTOR AKT1
47	ganglioglioma	9.9	TSC2 TSC1 NF1 KIAA1549
48	fibrillary astrocytoma	9.9	PTEN NF1 KIAA1549
49	kidney cancer	9.9	TSC2 TSC1 PTEN MTOR AKT1
50	obstructive hydrocephalus	9.9	TSC2 TSC1 RICTOR NF1

Graphical network of the top 20 diseases related to Subependymal Glioma:

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Symptoms & Phenotypes for Subependymal Glioma

UMLS symptoms related to Subependymal Glioma:

headache, motor manifestations, sensory manifestations

GenomeRNAi Phenotypes related to Subependymal Glioma according to GeneCards Suite gene sharing:

²⁶ (show all 39)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-11	10.37	MTOR RHEB
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-117	10.37	TSC1
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-152	10.37	PTEN
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-16	10.37	AKT1 MTOR RHEB
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-169	10.37	RICTOR
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-173	10.37	MTOR RHEB
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-177	10.37	AKT1
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-203	10.37	TSC1
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-206	10.37	TSC1
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-216	10.37	RHEB
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-33	10.37	TSC1
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-42	10.37	AKT1 MTOR RHEB RICTOR
13	Decreased shRNA abundance (Z-score < -2)	GR00366-A-50	10.37	AKT1
14	Decreased shRNA abundance (Z-score < -2)	GR00366-A-53	10.37	MTOR
15	Decreased shRNA abundance (Z-score < -2)	GR00366-A-57	10.37	RHEB
16	Decreased shRNA abundance (Z-score < -2)	GR00366-A-66	10.37	RHEB
17	Decreased shRNA abundance (Z-score < -2)	GR00366-A-73	10.37	MTOR
18	Decreased shRNA abundance (Z-score < -2)	GR00366-A-79	10.37	AKT1
19	Decreased shRNA abundance (Z-score < -2)	GR00366-A-82	10.37	TSC1
20	Decreased viability	GR00055-A-1	10.23	MTOR
21	Decreased viability	GR00055-A-2	10.23	MTOR
22	Decreased viability	GR00221-A-1	10.23	AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
23	Decreased viability	GR00221-A-2	10.23	AKT1 NF1
24	Decreased viability	GR00221-A-3	10.23	AKT1
25	Decreased viability	GR00221-A-4	10.23	AKT1 MLST8 MTOR NF1
26	Decreased viability	GR00249-S	10.23	AKT1 NF1
27	Decreased viability	GR00301-A	10.23	RPS6KB1
28	Decreased viability	GR00342-S-1	10.23	MTOR
29	Decreased viability	GR00342-S-2	10.23	MTOR
30	Decreased viability	GR00381-A-1	10.23	RPS6KB1
31	Decreased viability	GR00386-A-1	10.23	NF1 RHEB
32	Decreased viability	GR00402-S-2	10.23	RPS6KB1
33	Decreased cell migration	GR00055-A-1	9.77	AKT1 RICTOR TSC1
34	Decreased cell migration	GR00055-A-3	9.77	MTOR RICTOR
35	Decreased viability with paclitaxel	GR00179-A-1	9.35	MTOR RPS6KB1
36	Decreased viability with paclitaxel	GR00179-A-2	9.35	MTOR
37	Decreased viability with paclitaxel	GR00179-A-3	9.35	MTOR RPS6KB1
38	Decreased sensitivity to paclitaxel	GR00112-A-0	9.32	NF1 PTEN
39	Reduced mammosphere formation	GR00396-S	9.17	AKT1S1 EIF4EBP1 MTOR PTEN RHEB RPS6

MGI Mouse Phenotypes related to Subependymal Glioma:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.34	AKT1 EIF4EBP1 EPRS1 FKBP1A MTOR NF1
2	growth/size/body region	MP:0005378	10.34	AKT1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A MLST8
3	homeostasis/metabolism	MP:0005376	10.33	AKT1 AKT1S1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A
4	cardiovascular system	MP:0005385	10.29	AKT1 EIF4EBP1 FKBP1A MLST8 MTOR NF1
5	embryo	MP:0005380	10.29	AKT1 EPRS1 FKBP1A MLST8 MTOR NF1
6	mortality/aging	MP:0010768	10.2	AKT1 DEPDC5 EIF4EBP1 EPRS1 FKBP1A MLST8
7	adipose tissue	MP:0005375	10.13	AKT1 EIF4EBP1 EPRS1 MTOR PTEN RICTOR
8	endocrine/exocrine gland	MP:0005379	10.11	AKT1 MTOR NF1 PTEN RICTOR RPS6
9	liver/biliary system	MP:0005370	10.02	AKT1 FKBP1A NF1 PTEN RICTOR RPS6
10	muscle	MP:0005369	10	AKT1 EIF4EBP1 FKBP1A MTOR NF1 PTEN
11	neoplasm	MP:0002006	9.7	AKT1 NF1 PTEN RICTOR RPS6KB1 TSC1
12	nervous system	MP:0003631	9.7	AKT1 AKT1S1 DEPDC5 FKBP1A MLST8 MTOR
13	skeleton	MP:0005390	9.28	AKT1 DEPDC5 EPRS1 MTOR NF1 PTEN

Sources

Drugs & Therapeutics for Subependymal Glioma

Drugs for Subependymal Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Temozolomide

Approved, Investigational

Phase 1

85622-93-1

5394

Synonyms:

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-1,2,3,5-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide

3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3,4-dihydro-3-Methyl-4-oxoimidazo(5,1-D)-as-tetrazine-8-carboxamide

3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-D)(1,2,3,5)tetrazine-8-carboxamide

3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide

3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide

85622-93-1

8-carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one

8-Carbamoyl-3-methylimidazo(5,1-D)-1,2,3,5-tetrazin-4(3H)-one

AC1L1K9B

AC-758

BIDD:GT0204

Bio-0147

BRN 5547136

C047246

C6H6N6O2

CCRG 81045

CCRG-81045

CCRIS 8996

CHEBI:153686

CHEMBL810

CID5394

CPD000466338

D06067

DB00853

Essex brand of temozolomide

HMS2051O12

HMS2090B08

I06-0149

I14-1943

LS-80558

M B 39831

m & b 39831

M & B 39831

m And b 39831

m And b-39831

M&B 39831

M&B-39831

M-39831

MB 39831

Methazolastone

MLS000759447

MLS001424028

MLS002701861

NCGC00167429-01

NCGC00167429-02

NCI60_003316

NSC 362856

NSC362856

NSC-362856

SAM001246636

Sch 52365

SCH 52365

Sch-52365

Schering brand of temozolomide

Schering-Plough brand of temozolomide

SMR000466338

STK623541

Temodal

Temodal (TN)

Temodar

Temozolamide

Temozolodida

Temozolodida [Spanish]

Temozolomid

Temozolomida

temozolomide

Temozolomide

Témozolomide

Temozolomide (JAN/USAN/INN)

Temozolomide [INN:BAN]

Temozolomidum

Temozolomidum [Latin]

TL8005593

TMZ

TMZ-Bioshuttle

UNII-YF1K15M17Y

ZINC01482184

Etanidazole

Investigational

Phase 1

22668-01-5

Protein Kinase Inhibitors

Phase 1

Erlotinib Hydrochloride

Phase 1

183319-69-9

176871

Liver Extracts

Phase 1

Alkylating Agents

Phase 1

Fluorides

Phase 1

Dopamine

Approved

Early Phase 1

51-61-6, 62-31-7

681

Synonyms:

(3H)-Dopamine

.alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane

.Beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)- (9CI)

1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride

1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium

153C5321-5FEE-4B0B-8925-F388F0EEEBD1

2-(3,4-dihydroxyphenyl)ethylamine

2-(3,4-Dihydroxyphenyl)ethylamine

2-benzenediol

3,4 Dihydroxyphenethylamine

3,4-dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine

3,4-Dihydroxyphenethylamine hydrochloride

3,4-Dihydroxyphenylethylamine

3-Hydroxtyramine

3-Hydroxytyramine

3-Hydroxytyramine Hydrobromide

3-Hydroxytyramine hydrochloride

4-(2-Aminoethyl)-1,

4-(2-aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-benzenediol

4-(2-Aminoethyl)-1,2-bezenediol

4-(2-Aminoethyl)benzene-1,2-diol

4-(2-aminoethyl)catechol

4-(2-Aminoethyl)catechol

4-(2-aminoethyl)pyrocatechol

4-(2-aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol

4-(2-Aminoethyl)-pyrocatechol

4-(2-Aminoethyl)pyrocatechol hydrochloride

50444-17-2

51-61-6

62-31-7 (HYDROCHLORIDE)

a-(3,4-Dihydroxyphenyl)-b-aminoethane

AC1L19S5

AC1Q54AX

AC1Q54AY

AKOS003790978

alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane

ASL 279

BIDD:ER0506

Biomol-NT_000001

BPBio1_001123

BSPBio_001932

C03758

CHEBI:18243

CHEMBL59

CID681

cMAP_000036

cMAP_000065

D07870

DB00988

Deoxyepinephrine

DivK1c_000780

Dopamin

Dopamina

Dopamina [INN-Spanish]

dopamine

Dopamine

Dopamine (INN)

Dopamine (USAN)(*hydrochloride*)

Dopamine [INN:BAN]

Dopamine hydrochloride

Dopaminum

Dopaminum [INN-Latin]

Dopastat

Dophamine

Dynatra

EINECS 200-110-0

HSDB 3068

Hydrochloride, dopamine

Hydroxytyramin

hydroxytyramine

Hydroxytyramine

IDI1_000780

intropin

Intropin

Intropin [*hydrochloride*]

IP 498

KBio1_000780

KBio2_001492

KBio2_002388

KBio2_002484

KBio2_004060

KBio2_004956

KBio2_005052

KBio2_006628

KBio2_007524

KBio2_007620

KBio3_001152

KBio3_002867

KBio3_002962

KBioGR_001129

KBioGR_002388

KBioGR_002484

KBioSS_001492

KBioSS_002393

KBioSS_002491

KW-3-060

L000232

L-DOPAMINE

LDP

Lopac0_000586

Lopac-H-8502

LS-159

Medopa (TN)

m-Hydroxytyramine hydrochloride

MolPort-001-641-000

NCGC00015519-01

NCGC00015519-08

NCGC00096050-01

NCGC00096050-02

NCGC00096050-03

NCGC00096050-04

NCGC00096050-05

nchembio.105-comp9

nchembio.107-comp4

nchembio.284-comp1

nchembio.78-comp16

nchembio.89-comp3

nchembio705-8

nchembio801-comp8

NINDS_000780

NSC 173182

NSC169105

NSC173182

Oprea1_088821

Oxytyramine

Pyrocatechol, 4-(2-aminoethyl)- (8CI)

Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride

Revimine

Revivan

SPBio_001205

Spectrum_001012

SPECTRUM1505155

Spectrum2_001023

Spectrum3_000406

Spectrum4_000525

Spectrum5_000945

ST048774

STK301601

UNII-VTD58H1Z2X

UPCMLD0ENAT5885989:001

Imidazole

Experimental, Investigational

288-32-4

795

Synonyms:

{Pyrro[b]monazole}

1,3-Diaza-2,4-cyclopentadiene

1,3-Diazole

1H-Imidazole

Al-imidazole

Cu-imidazole

Glyoxalin

Glyoxaline

Him

IMD

Imidazol

Imidazole acetate

Imidazole citrate

Imidazole conjugate monoacid

Imidazole monohydrochloride

Imidazole monophosphonate

Imidazole sodium

Imidazolium chloride

Iminazole

Imutex

Miazole

N,N'-1,2-ethenediylmethanimidamide

N,N'-vinyleneformamidine

pyrro(b)Monazole

pyrro[b]Monazole

Neurotransmitter Agents

Early Phase 1

Dihydroxyphenylalanine

Early Phase 1

Dopamine Agents

Early Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction	Completed	NCT00030498	Phase 1	erlotinib hydrochloride
2	Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study	Completed	NCT01119599	Phase 1	Gamma-Secretase Inhibitor RO4929097;Temozolomide
3	Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors	Terminated	NCT00110032	Phase 1	EF5
4	A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors	Active, not recruiting	NCT01165632	Early Phase 1	fluorine F 18 fluorodopa
5	Assessment of Hypoxia in Malignant Gliomas Using EF5	Terminated	NCT00430079		etanidazole
6	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Withdrawn	NCT02194452

Search NIH Clinical Center for Subependymal Glioma

Cochrane evidence based reviews: glioma, subependymal

Sources

Genetic Tests for Subependymal Glioma

Sources

Anatomical Context for Subependymal Glioma

MalaCards organs/tissues related to Subependymal Glioma:

⁴⁰

Brain, Liver

Sources

Publications for Subependymal Glioma

Articles related to Subependymal Glioma:

#	Title	Authors	PMID	Year
1	Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. ⁶¹	Cox RL...Yoshii A	30467464	2018
2	AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. ⁶¹	Piao Y...de Groot J	18957620	2009
3	[Histogenesis of subependymal glioma in Bourneville's tuberous sclerosis]. ⁶¹	Bancel B...Pialat J	2346568	1990
4	Long-term neurological sequelae in achondroplasia. ⁶¹	Hecht JT...Scott CI	6510432	1984
5	[Experimental brain tumors produced transplacentally by ethylnitrosourea (IV): ultrastructure studied by using transmission and scanning electron microscope (author's transl)]. ⁶¹	Taomoto K...Matsumoto S	708510	1978
6	PAPILLARY SUBEPENDYMAL GLIOSIS (GLIOMATOSIS) ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE AND SUBEPENDYMAL GLIOMA. ⁶¹	LU AT...EISENSTEIN BE	14063111	1963
7	Subependymal glioma with hypertension: diagnostic problem. ⁶¹	RODIN EA...DOCKERTY MB	14371747	1955

Sources

Genes for Subependymal Glioma

Genes related to Subependymal Glioma (0 elite genes):

(show all 22)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TSC2	TSC Complex Subunit 2	Protein Coding	8.96	DISEASES inferred ¹⁵
2	TSC1	TSC Complex Subunit 1	Protein Coding	8.74	DISEASES inferred ¹⁵
3	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	8.24	DISEASES inferred ¹⁵
4	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	7.53	DISEASES inferred ¹⁵ ¹⁵
5	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	7.37	DISEASES inferred ¹⁵
6	MIR323A	MicroRNA 323a	RNA Gene	7.15	DISEASES inferred ¹⁵ ¹⁵
7	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	6.76	DISEASES inferred ¹⁵
8	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	6.67	DISEASES inferred ¹⁵
9	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	6.58	DISEASES inferred ¹⁵
10	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	6.57	DISEASES inferred ¹⁵
11	TBC1D7	TBC1 Domain Family Member 7	Protein Coding	6.56	DISEASES inferred ¹⁵
12	KIAA1549	KIAA1549	Protein Coding	6.49	DISEASES inferred ¹⁵
13	MLST8	MTOR Associated Protein, LST8 Homolog	Protein Coding	6.45	DISEASES inferred ¹⁵
14	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	6.34	DISEASES inferred ¹⁵
15	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.34	DISEASES inferred ¹⁵
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.34	DISEASES inferred ¹⁵
17	AKT1S1	AKT1 Substrate 1	Protein Coding	6.21	DISEASES inferred ¹⁵
18	RPS6	Ribosomal Protein S6	Protein Coding	6.19	DISEASES inferred ¹⁵
19	DEPDC5	DEP Domain Containing 5, GATOR1 Subcomplex Subunit	Protein Coding	6.17	DISEASES inferred ¹⁵
20	NF1	Neurofibromin 1	Protein Coding	6.1	DISEASES inferred ¹⁵
21	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	6	DISEASES inferred ¹⁵
22	PRR5	Proline Rich 5	Protein Coding	5.95	DISEASES inferred ¹⁵

Sources

Variations for Subependymal Glioma

Sources

Expression for Subependymal Glioma

Search GEO for disease gene expression data for Subependymal Glioma.

Sources

Pathways for Subependymal Glioma

Pathways related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show top 50) (show all 90)

#	Super pathways	Score	Top Affiliating Genes
1	Signaling by GPCR ⁶⁵ Show member pathways GPCR downstream signaling ⁶⁵ Signal Transduction ⁶⁵	14.27	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
2	Gene Expression ⁶⁵ Show member pathways Generic Transcription Pathway ⁶⁵	13.92	TSC2 TSC1 RPTOR RPS6 RICTOR RHEB
3	HIV Life Cycle ⁶⁵ Show member pathways 2-LTR circle formation ⁶⁵ APOBEC3G mediated resistance to HIV-1 infection ⁶⁵ Assembly Of The HIV Virion ⁶⁵ Binding and entry of HIV virion ⁶⁵ Disease ⁶⁵ Diseases of signal transduction ⁶⁵ Early Phase of HIV Life Cycle ⁶⁵ HIV Infection ⁶⁵ Host Interactions of HIV factors ⁶⁵ Infectious disease ⁶⁵ Integration of provirus ⁶⁵ Late Phase of HIV Life Cycle ⁶⁵	13.8	TSC2 RPS6 RICTOR NF1 MTOR MLST8
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.49	TSC2 TSC1 RPS6KB1 PTEN MTOR EIF4EBP1
5	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁵ Show member pathways Complex I biogenesis ⁶⁵ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁵ Non-alcoholic fatty liver disease (NAFLD) ³⁶ Oxidative phosphorylation ³⁶ Oxidative phosphorylation ¹ Respiratory electron transport ⁶⁵ The citric acid (TCA) cycle and respiratory electron transport ⁶⁵ Thermogenesis ³⁶	13.42	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
6	Cellular Senescence (REACTOME) ⁶⁵ Show member pathways Cellular Senescence ⁶⁵ Oxidative Stress Induced Senescence ⁶⁵ Senescence-Associated Secretory Phenotype (SASP) ⁶⁵	13.23	TSC2 TSC1 RPTOR RHEB MTOR MLST8
7	GAB1 signalosome ⁶⁵ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁵ Negative regulation of the PI3K/AKT network ⁶⁵ PI3K/AKT activation ⁶⁵ PI3K/AKT Signaling in Cancer ⁶⁵ PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁵ PIP3 activates AKT signaling ⁶⁵ Role of LAT2/NTAL/LAB on calcium mobilization ⁶⁵	13.21	TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
8	p70S6K Signaling ⁶³ Show member pathways mTOR Pathway ⁶³ Renin-Angiotensin Pathway ⁶³	13.21	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
9	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.15	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
10	TNFR1 Pathway ⁶³ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis through Death Receptors ⁶³ Apoptotic Pathways Triggered By HIV1 ⁶³ Death Receptor Signaling ⁶⁶ DR3 Signaling ⁶³ Fas Signaling ⁶³ GITR Pathway ⁶³ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁵ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶³ TNF Signaling ⁶⁶ TRAIL Pathway ⁶³ TWEAK Pathway ⁶³	13.12	TSC2 RPS6KB1 RHEB PTEN MTOR AKT1
11	Regulation of TP53 Activity ⁶⁵ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁵ Regulation of TP53 Activity through Methylation ⁶⁵ Regulation of TP53 Activity through Phosphorylation ⁶⁵ Transcriptional Regulation by TP53 ⁶⁵	13.11	TSC2 TSC1 RPTOR RICTOR RHEB PTEN
12	Regulation of lipid metabolism Insulin signaling-generic cascades ²² Show member pathways acetyl-CoA biosynthesis from citrate ¹ Butyrate-induced histone acetylation ¹ Cell adhesion PLAU signaling ²² Class IB PI3K non-lipid kinase events ¹ Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² ErbB2/ErbB3 signaling events ¹ Glucose Homeostasis ¹ Insulin signaling pathway ³⁶ IRS activation ⁶⁵ Signal attenuation ⁶⁵ Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation Insulin regulation of translation ²²	13.08	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
13	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13.06	TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
14	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	13	TSC2 RPS6KB1 RHEB PTEN MTOR EIF4EBP1
15	NFAT and Cardiac Hypertrophy ⁶³ Show member pathways IGF1R Signaling ⁶³ Signaling Involved in Cardiac Hypertrophy ⁶³	12.9	RPS6KB1 RPS6 PTEN MTOR AKT1
16	Herpes simplex virus 1 infection ³⁶	12.9	TSC2 TSC1 RHEB MTOR EIF4EBP1 AKT1
17	Downstream signaling events of B Cell Receptor (BCR) ⁶⁵ Show member pathways Activation of RAS in B cells ⁶⁵ Signaling by the B Cell Receptor (BCR) ⁶⁵	12.87	TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
18	Beta-Adrenergic Signaling ⁶³ Show member pathways CDK5 Pathway ⁶³ Erythropoietin Pathway ⁶³ Insulin Receptor Pathway ⁶³	12.86	RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
19	Development HGF signaling pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development Neurotrophin family signaling ²² MET activates PTPN11 ⁶⁵ MET activates STAT3 ⁶⁵ Neurotrophin signaling pathway ³⁶ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.86	RPTOR PTEN MTOR MLST8 EIF4EBP1 AKT1S1
20	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁴ Show member pathways Adipocytokines and Insulin Signaling ⁶⁴ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁴ IL-2 Signaling Pathways ⁶⁴ IL-21 Signaling Pathways ⁶⁴ IL-4 Signaling Pathways ⁶⁴ IL-7 Signaling Pathways ⁶⁴ IL-9 Pathway ⁶³ IL-9 Signaling Pathways ⁶⁴ Immune response IL-9 signaling pathway ²²	12.84	RPS6KB1 RPS6 PTEN MTOR AKT1
21	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.81	TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
22	ErbB signaling pathway ³⁶ ¹ Show member pathways EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ³⁶ Renal cell carcinoma ³⁶ TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer ¹	12.76	RPS6KB1 RPS6 PTEN NF1 MTOR EIF4EBP1
23	Development Endothelin-1/EDNRA signaling ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA transactivation of EGFR ²² GnRH signaling pathway ³⁶ Inflammatory mediator regulation of TRP channels ³⁶	12.73	TSC2 RPS6KB1 RHEB MTOR AKT1
24	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁶ AMPK Signaling Pathway ⁶⁶	12.69	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
25	Prolactin Signaling Pathway ³⁶ ¹ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.63	RPS6KB1 RPS6 PTEN MTOR EIF4EBP1 AKT1
26	Angiopoietin Like Protein 8 Regulatory Pathway ¹ Show member pathways Insulin Signaling ¹ Liver X Receptor Pathway ¹	12.63	TSC2 TSC1 RPTOR RPS6KB1 RICTOR RHEB
27	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.6	RPTOR RPS6KB1 PTEN MTOR AKT1S1 AKT1
28	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.59	TSC2 TSC1 RPS6KB1 RPS6 RHEB PTEN
29	Phospholipase D signaling pathway ³⁶ Show member pathways Choline metabolism in cancer ³⁶	12.57	TSC2 TSC1 RPS6KB1 RHEB MTOR EIF4EBP1
30	Shigellosis ³⁶	12.51	RPTOR RPS6KB1 MTOR AKT1S1 AKT1
31	Translation Non-genomic (rapid) action of Androgen Receptor ²² Show member pathways Basal cell carcinoma ³⁶ Transcription Androgen Receptor nuclear signaling ²²	12.46	TSC2 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
32	Translational Control ⁴	12.42	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
33	CNTF Signaling ⁶³ Show member pathways FLT3 Signaling ⁶³ IL-3 Pathway ⁶³ Nur77-Induced AICD in Macrophage ⁶³ OSM Pathway ⁶³	12.4	RPS6KB1 MTOR EIF4EBP1 AKT1
34	AMPK Enzyme Complex Pathway ⁶³ Show member pathways Chromatin Remodeling ⁶³ mitochondrial L-carnitine shuttle ¹	12.4	TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
35	G-protein signaling Ras family GTPases in kinase cascades (scheme) ²² Show member pathways Activation of the AP-1 family of transcription factors ⁶⁵ Immune response Oncostatin M signaling via MAPK in human cells ²² MAPK Cascade ¹ Nanoparticle-mediated activation of receptor signaling ¹ Oncostatin M Signaling Pathway ¹	12.38	RPS6 RICTOR MTOR AKT1
36	Proteoglycans in cancer ³⁶	12.37	RPS6KB1 RPS6 MTOR AKT1
37	mTOR signalling ⁶⁵ Show member pathways Energy dependent regulation of mTOR by LKB1-AMPK ⁶⁵ Inhibition of TSC complex formation by PKB ⁶⁵ mTORC1-mediated signalling ⁶⁵ PDE3B signalling ⁶⁵ PI3K Cascade ⁶⁵ PKB-mediated events ⁶⁵ Target Of Rapamycin (TOR) Signaling ¹	12.37	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
38	EGF/EGFR Signaling Pathway ¹	12.35	RPS6KB1 RICTOR PTEN MTOR EIF4EBP1 AKT1
39	Cellular senescence (KEGG) ³⁶	12.35	TSC2 TSC1 RHEB PTEN MTOR EIF4EBP1
40	Autophagy Pathway ⁶⁶	12.34	RPTOR MTOR MLST8 AKT1S1
41	Integrated Breast Cancer Pathway ¹	12.34	TSC2 TSC1 RHEB PTEN NF1 MTOR
42	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	12.33	TSC2 TSC1 RPTOR RPS6KB1 RHEB MTOR
43	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.29	RICTOR MTOR MLST8 AKT1
44	Cellular response to heat stress ⁶⁵ Show member pathways HSF1 activation ⁶⁵ Regulation of HSF1-mediated heat shock response ⁶⁵	12.29	RPTOR MTOR MLST8 AKT1S1
45	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway ¹	12.28	TSC2 RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
46	Kit receptor signaling pathway ¹ Show member pathways IL-3 Signaling Pathway ¹ Signaling events mediated by Stem cell factor receptor (c-Kit) ¹	12.26	RPS6KB1 RPS6 PTEN AKT1
47	Apelin signaling pathway ³⁶	12.18	RPS6KB1 RPS6 MTOR AKT1
48	Glioblastoma Multiforme ⁶³	12.18	TSC2 TSC1 RPS6KB1 PTEN NF1 MTOR
49	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	12.17	TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
50	UVA-Induced MAPK Signaling ⁶³ Show member pathways UVB-Induced MAPK Signaling ⁶³	12.16	RPS6KB1 MTOR EIF4EBP1 AKT1

Sources

GO Terms for Subependymal Glioma

Cellular components related to Subependymal Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:0005737	10.24	TSC2 TSC1 RPTOR RPS6KB1 RHEB PTEN
2	cytosol	GO:0005829	9.58	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3	postsynaptic cytosol	GO:0099524	9.43	PTEN MTOR EIF4EBP1
4	TORC2 complex	GO:0031932	9.33	RICTOR MTOR MLST8
5	TSC1-TSC2 complex	GO:0033596	9.32	TSC2 TSC1
6	TORC1 complex	GO:0031931	9.26	RPTOR MTOR MLST8 AKT1S1

Biological processes related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show all 39)

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-serine phosphorylation	GO:0018105	9.92	RPS6KB1 RICTOR MTOR AKT1
2	cell cycle arrest	GO:0007050	9.89	RPTOR RHEB MTOR MLST8
3	cellular response to hypoxia	GO:0071456	9.88	PTEN MTOR EIF4EBP1 AKT1
4	cellular response to insulin stimulus	GO:0032869	9.86	RPS6KB1 PTEN EPRS1 AKT1
5	regulation of GTPase activity	GO:0043087	9.85	RICTOR NF1 MTOR MLST8
6	regulation of translation	GO:0006417	9.85	TSC1 RPS6KB1 EPRS1 EIF4EBP1 AKT1
7	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.84	RICTOR MTOR MLST8
8	negative regulation of protein kinase activity	GO:0006469	9.84	TSC2 NF1 AKT1S1 AKT1
9	negative regulation of translation	GO:0017148	9.83	TSC1 EPRS1 EIF4EBP1
10	regulation of actin cytoskeleton organization	GO:0032956	9.83	RICTOR MTOR MLST8
11	regulation of autophagy	GO:0010506	9.82	RPTOR MTOR DEPDC5
12	regulation of cellular response to heat	GO:1900034	9.81	RPTOR MTOR MLST8 AKT1S1
13	negative regulation of protein kinase B signaling	GO:0051898	9.8	TSC2 PTEN AKT1
14	positive regulation of actin filament polymerization	GO:0030838	9.8	RICTOR MTOR MLST8
15	regulation of macroautophagy	GO:0016241	9.8	RPTOR RHEB MTOR MLST8
16	protein kinase B signaling	GO:0043491	9.78	TSC2 PTEN AKT1
17	phosphatidylinositol 3-kinase signaling	GO:0014065	9.77	PTEN NF1 AKT1
18	negative regulation of insulin receptor signaling pathway	GO:0046627	9.75	TSC2 TSC1 RPS6KB1
19	spinal cord development	GO:0021510	9.74	NF1 MTOR AKT1
20	regulation of protein kinase B signaling	GO:0051896	9.7	RICTOR PTEN MTOR
21	positive regulation of lipid biosynthetic process	GO:0046889	9.68	MTOR AKT1
22	regulation of synaptic transmission, GABAergic	GO:0032228	9.68	PTEN NF1
23	insulin-like growth factor receptor signaling pathway	GO:0048009	9.67	TSC2 AKT1
24	cellular response to nutrient levels	GO:0031669	9.67	RPTOR MTOR
25	positive regulation of TOR signaling	GO:0032008	9.67	RPTOR RICTOR RHEB MLST8
26	regulation of cell-matrix adhesion	GO:0001952	9.66	TSC1 NF1
27	regulation of glycogen biosynthetic process	GO:0005979	9.66	MTOR AKT1
28	negative regulation of macroautophagy	GO:0016242	9.65	TSC1 MTOR AKT1
29	positive regulation of endothelial cell proliferation	GO:0001938	9.65	RPTOR RICTOR NF1 MTOR AKT1
30	cellular response to leucine	GO:0071233	9.64	RPTOR MTOR
31	positive regulation of transcription by RNA polymerase III	GO:0045945	9.64	RPTOR MTOR
32	forebrain morphogenesis	GO:0048853	9.63	PTEN NF1
33	activation of protein kinase B activity	GO:0032148	9.62	RICTOR MTOR MLST8 AKT1
34	cellular response to decreased oxygen levels	GO:0036294	9.61	PTEN AKT1
35	anoikis	GO:0043276	9.61	TSC2 MTOR AKT1
36	TORC1 signaling	GO:0038202	9.58	RPTOR MTOR MLST8
37	negative regulation of TOR signaling	GO:0032007	9.55	TSC2 TSC1 TBC1D7 DEPDC5 AKT1S1
38	negative regulation of cell size	GO:0045792	9.35	TSC1 PTEN MTOR AKT1S1 AKT1
39	TOR signaling	GO:0031929	9.23	RPTOR RPS6KB1 RPS6 RICTOR MTOR MLST8

Molecular functions related to Subependymal Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	GTPase activator activity	GO:0005096	9.76	TSC2 TBC1D7 NF1 DEPDC5
2	GTPase activating protein binding	GO:0032794	9.48	TSC1 AKT1
3	RNA polymerase III type 3 promoter sequence-specific DNA binding	GO:0001006	9.43	RPTOR MTOR
4	RNA polymerase III type 3 promoter DNA binding	GO:0001032	9.4	RPTOR MTOR
5	RNA polymerase III type 2 promoter sequence-specific DNA binding	GO:0001003	9.37	RPTOR MTOR
6	RNA polymerase III type 1 promoter sequence-specific DNA binding	GO:0001002	9.32	RPTOR MTOR
7	TFIIIC-class transcription factor complex binding	GO:0001156	9.26	RPTOR MTOR
8	protein kinase binding	GO:0019901	9.17	RPTOR RPS6 RICTOR RHEB PTEN MTOR
9	RNA polymerase III type 2 promoter DNA binding	GO:0001031	9.16	RPTOR MTOR
10	RNA polymerase III type 1 promoter DNA binding	GO:0001030	8.96	RPTOR MTOR

Sources

Sources for Subependymal Glioma

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