Subependymal Glioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Subependymal Glioma

MalaCards integrated aliases for Subependymal Glioma:

Name: Subependymal Glioma ¹¹ ¹⁴ ¹⁶ ⁷¹

Mixed Subependymoma-Ependymoma ¹¹

Who Grade I Ependymal Tumor ¹¹

Subependymal Astrocytoma ¹¹

Glioma, Subependymal ⁴³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4843

MeSH ⁴³ D018315

NCIt ⁴⁹ C3795

SNOMED-CT ⁶⁸ 4553004

EFO ¹⁶ EFO_1001197

UMLS ⁷¹ C0206725

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Summaries for Subependymal Glioma

MalaCards based summary: Subependymal Glioma, also known as mixed subependymoma-ependymoma, is related to tuberous sclerosis 1 and tuberous sclerosis, and has symptoms including headache, motor manifestations and sensory manifestations. An important gene associated with Subependymal Glioma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Disease and Signal Transduction. The drugs Erlotinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and spinal cord, and related phenotypes are Decreased viability and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Subependymal Glioma

Diseases related to Subependymal Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)

#	Related Disease	Score	Top Affiliating Genes
1	tuberous sclerosis 1	30.3	TSC2 TSC1
2	tuberous sclerosis	28.7	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3	subependymal giant cell astrocytoma	27.9	TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RICTOR
4	subependymoma	11.2
5	multilocular clear cell renal cell carcinoma	10.3	TSC2 TSC1
6	angiomyolipoma	10.3	TSC2 TSC1 MTOR
7	hepatic angiomyolipoma	10.3	TSC2 TSC1
8	liver lipoma	10.3	TSC2 TSC1
9	perivascular epithelioid cell tumor	10.3	TSC2 TSC1 MTOR
10	exudative vitreoretinopathy 6	10.3	MTOR FKBP1A
11	focal cortical dysplasia, type ii	10.3	TSC2 TSC1 MTOR
12	birt-hogg-dube syndrome	10.3	TSC2 TSC1 MTOR
13	epithelioid type angiomyolipoma	10.3	TSC2 TSC1
14	uterus perivascular epithelioid cell tumor	10.3	TSC2 TSC1 RPS6KB1
15	optic nerve neoplasm	10.3	NF1 MTOR KIAA1549
16	connective tissue benign neoplasm	10.3	TSC2 TSC1 NF1
17	epidural spinal canal neoplasm	10.2	NF1 KIAA1549
18	congenital heart defects, hamartomas of tongue, and polysyndactyly	10.2	TSC2 TSC1 PTEN
19	ganglioglioma	10.2	TSC2 TSC1 NF1
20	cowden syndrome 4	10.2	TSC2 PTEN
21	multiple mucosal neuroma	10.2	PTEN NF1
22	megalencephaly	10.2	TBC1D7 PTEN MTOR
23	skin lipoma	10.2	PTEN NF1
24	polycystic kidney disease 1 with or without polycystic liver disease	10.2	TSC2 TSC1 MTOR
25	angiolipoma	10.2	TSC2 TSC1
26	simple partial epilepsy	10.2	KIAA1549 IDH1
27	hypomelanosis of ito	10.2	TSC2 NF1 DEPDC5
28	glioma susceptibility 1	10.2
29	glioma	10.2
30	glial tumor	10.2
31	obstructive hydrocephalus	10.2	TSC2 TSC1 NF1 KIAA1549
32	adult brain stem glioma	10.2	KIAA1549 IDH1
33	thalamic neoplasm	10.2	MYBL1 KIAA1549
34	sturge-weber syndrome	10.2	TSC2 NF1 DEPDC5
35	peutz-jeghers syndrome	10.2	TSC2 TSC1 PTEN
36	pyriform sinus cancer	10.2	RPS6 MTOR EIF4EBP1
37	congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	10.2	PTEN MTOR AKT1
38	respiratory system benign neoplasm	10.2	TSC2 PTEN AKT1
39	uterine benign neoplasm	10.2	TSC2 PTEN AKT1
40	reproductive organ benign neoplasm	10.1	TSC2 PTEN AKT1
41	corneal dystrophy, fleck	10.1	TSC2 TSC1 MTOR DEPDC5
42	optic nerve astrocytoma	10.1	TSC2 NF1 IDH1
43	estrogen-receptor positive breast cancer	10.1	PTEN MTOR AKT1
44	thymus gland disease	10.1	PTEN MTOR AKT1
45	kidney benign neoplasm	10.1	TSC2 TSC1 TBC1D7 RHEB MTOR
46	cystic kidney disease	10.1	TSC2 TSC1 MTOR AKT1
47	pervasive developmental disorder	10.1	TSC2 TSC1 PTEN MTOR
48	autosomal dominant polycystic kidney disease	10.1	TSC2 TSC1 MTOR AKT1
49	thymus cancer	10.1	PTEN MTOR AKT1
50	adult oligodendroglioma	10.1	KIAA1549 IDH1

Graphical network of the top 20 diseases related to Subependymal Glioma:

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Symptoms & Phenotypes for Subependymal Glioma

UMLS symptoms related to Subependymal Glioma:

headache; motor manifestations; sensory manifestations

GenomeRNAi Phenotypes related to Subependymal Glioma according to GeneCards Suite gene sharing:

²⁵ (show all 41)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-1	10.4	MTOR
2	Decreased viability	GR00055-A-2	10.4	MTOR
3	Decreased viability	GR00221-A-1	10.4	AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
4	Decreased viability	GR00221-A-2	10.4	AKT1 NF1
5	Decreased viability	GR00221-A-3	10.4	AKT1
6	Decreased viability	GR00221-A-4	10.4	AKT1 MLST8 MTOR NF1
7	Decreased viability	GR00249-S	10.4	AKT1 NF1
8	Decreased viability	GR00301-A	10.4	RPS6KB1
9	Decreased viability	GR00342-S-1	10.4	MTOR
10	Decreased viability	GR00342-S-2	10.4	MTOR
11	Decreased viability	GR00381-A-1	10.4	RPS6KB1
12	Decreased viability	GR00386-A-1	10.4	NF1 RHEB
13	Decreased viability	GR00402-S-2	10.4	RPS6KB1
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	10.31	RICTOR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-104	10.31	RICTOR
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	10.31	MTOR RHEB
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-116	10.31	TSC1
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-127	10.31	TSC1
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-151	10.31	PTEN
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	10.31	PTEN
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	10.31	PTEN
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-189	10.31	RICTOR
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-211	10.31	RICTOR
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-213	10.31	AKT1
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-214	10.31	PTEN
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-27	10.31	RICTOR
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	10.31	PTEN TSC1
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-58	10.31	RICTOR
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-60	10.31	AKT1 MTOR
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	10.31	PTEN RHEB
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-66	10.31	PTEN
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	10.31	AKT1
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	10.31	AKT1 MTOR
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-87	10.31	PTEN
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-93	10.31	PTEN
36	Decreased viability with paclitaxel	GR00179-A-1	9.55	MTOR RPS6KB1
37	Decreased viability with paclitaxel	GR00179-A-2	9.55	MTOR
38	Decreased viability with paclitaxel	GR00179-A-3	9.55	MTOR RPS6KB1
39	Increased cell migration	GR00055-A-1	9.26	NF1
40	Increased cell migration	GR00055-A-3	9.26	NF1
41	Reduced mammosphere formation	GR00396-S	9.17	AKT1S1 EIF4EBP1 MTOR PTEN RHEB RPS6

MGI Mouse Phenotypes related to Subependymal Glioma:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.41	AKT1 AKT1S1 DEPDC5 EIF4EBP1 FKBP1A IDH1
2	growth/size/body region	MP:0005378	10.36	AKT1 DEPDC5 EIF4EBP1 FKBP1A IDH1 MLST8
3	nervous system	MP:0003631	10.32	AKT1 AKT1S1 DEPDC5 FKBP1A IDH1 MLST8
4	muscle	MP:0005369	10.27	AKT1 EIF4EBP1 FKBP1A MTOR NF1 PTEN
5	endocrine/exocrine gland	MP:0005379	10.15	AKT1 MTOR MYBL1 NF1 PTEN RHEB
6	liver/biliary system	MP:0005370	10.13	AKT1 FKBP1A NF1 PTEN RICTOR RPS6
7	adipose tissue	MP:0005375	10.11	AKT1 DEPDC5 EIF4EBP1 KIAA1549 MTOR PTEN
8	embryo	MP:0005380	10.1	AKT1 FKBP1A MLST8 MTOR NF1 PTEN
9	cellular	MP:0005384	10.1	AKT1 EIF4EBP1 FKBP1A MTOR MYBL1 NF1
10	neoplasm	MP:0002006	10.07	AKT1 NF1 PTEN RICTOR RPS6KB1 TSC1
11	cardiovascular system	MP:0005385	9.97	AKT1 EIF4EBP1 FKBP1A MLST8 MTOR NF1
12	reproductive system	MP:0005389	9.65	AKT1 MYBL1 NF1 PTEN RHEB RICTOR
13	mortality/aging	MP:0010768	9.5	AKT1 DEPDC5 EIF4EBP1 FKBP1A IDH1 MLST8

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Drugs & Therapeutics for Subependymal Glioma

Drugs for Subependymal Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Erlotinib

Approved, Investigational

Phase 1

183319-69-9, 183321-74-6

176870

2

Temozolomide

Approved, Investigational

Phase 1

85622-93-1

5394

3

Etanidazole

Investigational

Phase 1

22668-01-5

3276

4

Liver Extracts

Phase 1

5

Protein Kinase Inhibitors

Phase 1

6

R04929097

Phase 1

7

Alkylating Agents

Phase 1

8

Antineoplastic Agents, Alkylating

Phase 1

9

Fluorides

Phase 1

10

Imidazole

Experimental, Investigational

288-32-4

795

11

Dihydroxyphenylalanine

Early Phase 1

12

Protective Agents

Early Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction	Completed	NCT00030498	Phase 1	erlotinib hydrochloride
2	Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study	Completed	NCT01119599	Phase 1	Gamma-Secretase Inhibitor RO4929097;Temozolomide
3	Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors	Terminated	NCT00110032	Phase 1	EF5
4	A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors	Active, not recruiting	NCT01165632	Early Phase 1	fluorine F 18 fluorodopa
5	Assessment of Hypoxia in Malignant Gliomas Using EF5	Terminated	NCT00430079		etanidazole
6	Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors	Withdrawn	NCT02194452

Search NIH Clinical Center for Subependymal Glioma

Cochrane evidence based reviews: glioma, subependymal

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Genetic Tests for Subependymal Glioma

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Anatomical Context for Subependymal Glioma

Organs/tissues related to Subependymal Glioma:

MalaCards : Brain, Liver, Spinal Cord

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Publications for Subependymal Glioma

Articles related to Subependymal Glioma:

(show all 17)

#	Title	Authors	PMID	Year
1	Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis. ⁶²	Kweh BTS...Tee JW	34416731	2022
2	Clinical features and surgical outcomes of intracranial and spinal cord subependymomas. ⁶²	Rincon-Torroella J...Bettegowda C	35148513	2022
3	Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. ⁶²	Cox RL...Yoshii A	30467464	2018
4	AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. ⁶²	Piao Y...de Groot J	18957620	2009
5	[Histogenesis of subependymal glioma in Bourneville's tuberous sclerosis]. ⁶²	Bancel B...Pialat J	2346568	1990
6	Human neonatal hydrocephalus. An electron microscopic study of the periventricular tissue. ⁶²	Del Bigio MR...Fewer HD	4009275	1985
7	Cerebellar hemangioblastoma and subependymoma: a case report of an unprecedented association. ⁶²	Escalona-Zapata J...Benito C	3995811	1985
8	Third ventricle gliomas. Report of 7 cases with benign clinical behaviour. ⁶²	Casotto A...Giordana MT	3976445	1985
9	Intraventricular tumors in tuberous sclerosis. ⁶²	Frerebeau P...Marty-Double C	3986841	1985
10	Long-term neurological sequelae in achondroplasia. ⁶²	Hecht JT...Scott CI	6510432	1984
11	[A rare case of epiphysiolysis in an adult patient with a subependymal astrocytoma. Etiopathogenetic considerations]. ⁶²	Falcone G...Falcone S	6544099	1984
12	Evaluation of the histopathology of brain tumor tissue obtained by ultrasonic aspiration. ⁶²	Richmond IL...Hawksley CA	6633835	1983
13	Subependymal astrocytoma of the septum pellucidum: case report and brief review. ⁶²	Clark RM...Adams JC	277740	1978
14	[Experimental brain tumors produced transplacentally by ethylnitrosourea (IV): ultrastructure studied by using transmission and scanning electron microscope (author's transl)]. ⁶²	Taomoto K...Matsumoto S	708510	1978
15	PAPILLARY SUBEPENDYMAL GLIOSIS (GLIOMATOSIS) ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE AND SUBEPENDYMAL GLIOMA. ⁶²	LU AT...EISENSTEIN BE	14063111	1963
16	[SUBEPENDYMAL ASTROCYTOMA GIGANTOCELLULARE AND ITS RELATIONSHIP WITH TUBEROUS SCLEROSIS]. ⁶²	ESCALONAZAPATA J	14279433	1963
17	Subependymal glioma with hypertension: diagnostic problem. ⁶²	RODIN EA...DOCKERTY MB	14371747	1955

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Genes for Subependymal Glioma

Genes related to Subependymal Glioma (0 elite genes):

(show all 23)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TSC2	TSC Complex Subunit 2	Protein Coding	8.88	DISEASES inferred ¹⁴
2	TSC1	TSC Complex Subunit 1	Protein Coding	8.59	DISEASES inferred ¹⁴
3	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	8	DISEASES inferred ¹⁴
4	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	7.09	DISEASES inferred ¹⁴
5	TBC1D7	TBC1 Domain Family Member 7	Protein Coding	6.7	DISEASES inferred ¹⁴
6	KIAA1549	KIAA1549	Protein Coding	6.5	DISEASES inferred ¹⁴
7	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	6.5	DISEASES inferred ¹⁴
8	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	6.33	DISEASES inferred ¹⁴
9	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	6.26	DISEASES inferred ¹⁴
10	NF1	Neurofibromin 1	Protein Coding	6.22	DISEASES inferred ¹⁴
11	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	6.22	DISEASES inferred ¹⁴
12	MLST8	MTOR Associated Protein, LST8 Homolog	Protein Coding	6.09	DISEASES inferred ¹⁴
13	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	6.05	DISEASES inferred ¹⁴
14	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	6.03	DISEASES inferred ¹⁴
15	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6	DISEASES inferred ¹⁴
16	DEPDC5	DEP Domain Containing 5, GATOR1 Subcomplex Subunit	Protein Coding	5.92	DISEASES inferred ¹⁴
17	AKT1S1	AKT1 Substrate 1	Protein Coding	5.84	DISEASES inferred ¹⁴
18	RPS6	Ribosomal Protein S6	Protein Coding	5.82	DISEASES inferred ¹⁴
19	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	5.72	DISEASES inferred ¹⁴
20	MYBL1	MYB Proto-Oncogene Like 1	Protein Coding	5.71	DISEASES inferred ¹⁴
21	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	5.71	DISEASES inferred ¹⁴
22	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	5.67	DISEASES inferred ¹⁴
23	ATRX	ATRX Chromatin Remodeler	Protein Coding	5.58	DISEASES inferred ¹⁴

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Variations for Subependymal Glioma

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Expression for Subependymal Glioma

Search GEO for disease gene expression data for Subependymal Glioma.

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Pathways for Subependymal Glioma

Pathways related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show top 50) (show all 88)

#	Super pathways	Score	Top Affiliating Genes
1	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.92	TSC2 RPS6 RICTOR PTEN NF1 MTOR
2	Signal Transduction ⁶⁶	13.92	AKT1 AKT1S1 EIF4EBP1 FKBP1A MLST8 MTOR
3	Cellular responses to stimuli ⁶⁶ Show member pathways Cellular responses to stress ⁶⁶	13.58	RPTOR RPS6 RHEB MTOR MLST8 IDH1
4	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.57	AKT1 EIF4EBP1 MTOR NF1 PTEN RPS6
5	RAF/MAP kinase cascade ⁶⁶ Show member pathways Diseases of signal transduction by growth factor receptors and second messengers ⁶⁶ MAPK family signaling cascades ⁶⁶ MAPK1/MAPK3 signaling ⁶⁶	13.53	AKT1 AKT1S1 FKBP1A KIAA1549 MLST8 MTOR
6	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.48	TSC2 TSC1 RPS6KB1 PTEN MTOR EIF4EBP1
7	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.27	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
8	PIP3 activates AKT signaling ⁶⁶ Show member pathways Intracellular signaling by second messengers ⁶⁶ PTEN Regulation ⁶⁶ Regulation of PTEN gene transcription ⁶⁶ Regulation of PTEN localization ⁶⁶	13.22	TSC2 RPTOR RICTOR RHEB PTEN MTOR
9	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	13.18	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
10	Regulation of TP53 Activity ⁶⁶ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁶ Regulation of TP53 Activity through Methylation ⁶⁶ Regulation of TP53 Activity through Phosphorylation ⁶⁶ Transcriptional Regulation by TP53 ⁶⁶	13.13	TSC2 TSC1 RPTOR RICTOR RHEB PTEN
11	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.98	TSC2 RPS6KB1 RHEB PTEN MTOR AKT1
12	Translation Insulin regulation of translation ²² Show member pathways Butyrate-induced histone acetylation ⁷⁴ Cell adhesion PLAU signaling ²² Development CNTF receptor signaling ²² Development Growth hormone signaling via PI3K/AKT and MAPK cascades ²² Overview of perturbations to host-cell autophagy, induced by distinct proteins of SARS-CoV-2 ⁷⁴ Regulation of lipid metabolism Insulin signaling-generic cascades ²² Transcription Receptor-mediated HIF regulation ²² Translation Regulation of EIF2 activity ²² Translation Regulation of EIF4F activity ²² Translation inhibitors in chronically activated PDGFRA cells ⁷⁴	12.96	TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
13	Malignant pleural mesothelioma ⁷⁴	12.94	AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
14	Beta-Adrenergic Signaling ⁶⁴ Show member pathways CDK5 Pathway ⁶⁴ Erythropoietin Pathway ⁶⁴ Insulin Pathway ⁷⁰ Insulin Receptor Pathway ⁶⁴	12.92	RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
15	NFAT and Cardiac Hypertrophy ⁶⁴ Show member pathways IGF1R Signaling ⁶⁴ Signaling Involved in Cardiac Hypertrophy ⁶⁴	12.9	RPS6KB1 RPS6 PTEN MTOR AKT1
16	IL-9 Signaling Pathways ⁶⁵ Show member pathways Adipocytokines and Insulin Signaling ⁶⁵ Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Pathway ⁶⁴ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ Immune response IL-9 signaling pathway ²² Interleukin-9 signaling ⁶⁶	12.9	RPS6KB1 RPS6 PTEN MTOR AKT1
17	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.86	TSC2 RPS6KB1 RHEB PTEN NF1 MTOR
18	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁶ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁶ Negative regulation of the PI3K/AKT network ⁶⁶ PI3K/AKT Signaling in Cancer ⁶⁶	12.84	TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
19	Selective autophagy ⁶⁶ Show member pathways Aggrephagy ⁶⁶ Autophagy ⁶⁶ Lipophagy ⁶⁶ Macroautophagy ⁶⁶ Pexophagy ⁶⁶	12.83	TSC2 TSC1 RPTOR RHEB MTOR MLST8
20	Angiopoietin-like protein 8 regulatory pathway ⁷⁴ Show member pathways Insulin signaling ⁷⁴ Liver X receptor pathway ⁷⁴	12.76	AKT1 EIF4EBP1 MLST8 MTOR PTEN RHEB
21	Glucose / Energy Metabolism ³	12.62	TSC2 RPTOR PTEN IDH1 AKT1
22	Autophagy pathway ⁶⁷ Show member pathways AKT Signaling Pathway ⁶⁷	12.52	RPTOR MTOR MLST8 AKT1S1
23	Development IGF-1 receptor signaling ²² Show member pathways Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	12.52	AKT1 EIF4EBP1 MTOR PTEN RHEB RPS6
24	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.51	AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
25	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.49	RPS6KB1 PTEN MTOR AKT1
26	Rab regulation of trafficking ⁶⁶ Show member pathways RAB GEFs exchange GTP for GDP on RABs ⁶⁶ TBC/RABGAPs ⁶⁶	12.48	TSC2 TSC1 TBC1D7 AKT1
27	PDGFR-beta signaling pathway ⁶¹ Show member pathways ErbB1 downstream signaling ⁶¹	12.45	RPS6 RICTOR PTEN MTOR MLST8 AKT1
28	mTOR Signaling ⁶⁵	12.45	AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
29	CD28 co-stimulation ⁶⁶ Show member pathways Activation of AKT2 ⁶⁶ CD28 dependent PI3K/Akt signaling ⁶⁶ CD28 dependent Vav1 pathway ⁶⁶ Costimulation by the CD28 family ⁶⁶ CTLA4 Signaling ⁶⁴ VEGFR2 mediated vascular permeability ⁶⁶	12.44	AKT1 MLST8 MTOR RICTOR
30	B Cell Receptor Signaling Pathway ⁶⁷ Show member pathways T Cell Receptor Signaling Pathway ⁶⁷	12.43	RPS6KB1 PTEN MTOR AKT1S1 AKT1
31	AMPK Enzyme Complex Pathway ⁶⁴ Show member pathways Chromatin Remodeling ⁶⁴	12.42	TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
32	MTOR signalling ⁶⁶ Show member pathways Energy dependent regulation of mTOR by LKB1-AMPK ⁶⁶ Inhibition of TSC complex formation by PKB ⁶⁶ mTORC1-mediated signalling ⁶⁶ Target of rapamycin signaling ⁷⁴	12.41	AKT1 AKT1S1 EIF4EBP1 FKBP1A MLST8 MTOR
33	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.4	TSC2 TSC1 RPTOR RICTOR RHEB PTEN
34	Development Endothelin-1/EDNRA transactivation of EGFR ²² Show member pathways Cytoskeleton remodeling FAK signaling ²² Development Endothelin-1/EDNRA signaling ²²	12.39	AKT1 MTOR RHEB RPS6KB1 TSC2
35	Signaling by VEGF ⁶⁶ Show member pathways VEGFA-VEGFR2 Pathway ⁶⁶	12.37	RICTOR MTOR MLST8 AKT1
36	Integrated breast cancer pathway ⁷⁴	12.37	TSC2 TSC1 RHEB PTEN NF1 MTOR
37	Fragile X syndrome ⁷⁴ Show member pathways Pilocytic astrocytoma ⁷⁴	12.36	AKT1 AKT1S1 MLST8 MTOR NF1 PTEN
38	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	12.31	TSC2 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
39	Autophagy ⁷⁴ Show member pathways Autophagy during CoV infection ⁷⁴ Host-pathogen interaction of human coronaviruses - autophagy ⁷⁴ Nanoparticle triggered autophagic cell death ⁷⁴ Neurodegeneration with brain iron accumulation (NBIA) subtypes pathway ⁷⁴	12.29	TSC2 TSC1 RPTOR RHEB MTOR MLST8
40	Cellular response to heat stress ⁶⁶ Show member pathways HSF1 activation ⁶⁶ Regulation of HSF1-mediated heat shock response ⁶⁶	12.27	RPTOR MTOR MLST8 AKT1S1
41	GDNF signaling ⁷⁴	12.23	RPTOR RPS6KB1 PTEN MTOR AKT1
42	Head and neck squamous cell carcinoma ⁷⁴	12.2	MLST8 MTOR PTEN RHEB RICTOR RPS6
43	Translation Translation regulation by Alpha-1 adrenergic receptors ²² Show member pathways Development Activation of ERK by Alpha-1 adrenergic receptors ²²	12.18	TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
44	Thermogenesis ⁷⁴ Show member pathways mitochondrial L-carnitine shuttle ⁶¹	12.14	AKT1S1 MLST8 MTOR RHEB RPS6 RPS6KB1
45	PI3K / Akt Signaling ³	12.13	TSC2 TSC1 TBC1D7 RHEB PTEN AKT1S1
46	TP53 Regulates Metabolic Genes ⁶⁶	12.13	AKT1 MLST8 MTOR PTEN RHEB RPTOR
47	IL2 signaling events mediated by STAT5 ⁶¹ Show member pathways IL2 signaling events mediated by PI3K ⁶¹ IL2-mediated signaling events ⁶¹ Interleukin-2 signaling ⁶⁶	12.12	RPS6KB1 RPS6 MTOR AKT1
48	p53 transcriptional gene network ⁷⁴	12.11	TSC2 RPTOR PTEN MTOR MLST8 AKT1S1
49	Gastrin signaling pathway ⁷⁴	12.08	RPS6KB1 RPS6 EIF4EBP1 AKT1
50	Senescence and autophagy in cancer ⁷⁴	12.05	PTEN MTOR MLST8 AKT1S1

Sources

GO Terms for Subependymal Glioma

Cellular components related to Subependymal Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:0005829	10.51	AKT1 AKT1S1 DEPDC5 EIF4EBP1 FKBP1A IDH1
2	TORC2 complex	GO:0031932	9.63	RICTOR MTOR MLST8
3	TSC1-TSC2 complex	GO:0033596	9.43	TSC2 TSC1 TBC1D7
4	TORC1 complex	GO:0031931	9.17	RPTOR MTOR MLST8 AKT1S1

Biological processes related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of apoptotic process	GO:0043066	10.41	AKT1 MLST8 MTOR PTEN RICTOR RPS6
2	phosphorylation	GO:0016310	10.34	AKT1 MLST8 MTOR RICTOR RPS6KB1 RPTOR
3	cellular response to hypoxia	GO:0071456	10.22	MLST8 MTOR PTEN RPTOR
4	regulation of GTPase activity	GO:0043087	10.19	RICTOR NF1 MTOR MLST8
5	negative regulation of protein kinase activity	GO:0006469	10.16	TSC2 NF1 AKT1S1 AKT1
6	negative regulation of autophagy	GO:0010507	10.13	RPTOR MTOR MLST8 AKT1
7	response to heat	GO:0009408	10.12	RPS6KB1 MTOR AKT1
8	positive regulation of actin filament polymerization	GO:0030838	10.12	RICTOR MTOR MLST8
9	phosphatidylinositol 3-kinase signaling	GO:0014065	10.11	PTEN NF1 AKT1
10	protein kinase B signaling	GO:0043491	10.11	TSC2 RPS6KB1 PTEN AKT1
11	germ cell development	GO:0007281	10.1	RPS6KB1 MTOR AKT1
12	positive regulation of cell growth	GO:0030307	10.1	RPTOR RICTOR MTOR MLST8 AKT1
13	oligodendrocyte differentiation	GO:0048709	10.09	RHEB NF1 MTOR
14	regulation of translation	GO:0006417	10.09	TSC1 RPS6KB1 EIF4EBP1 AKT1
15	positive regulation of glycolytic process	GO:0045821	10.05	RPTOR MTOR MLST8
16	positive regulation of TOR signaling	GO:0032008	10.03	RPTOR RICTOR RHEB MLST8
17	regulation of protein kinase B signaling	GO:0051896	10.02	RICTOR PTEN MTOR
18	negative regulation of macroautophagy	GO:0016242	10.01	AKT1 MTOR TSC1
19	cellular response to osmotic stress	GO:0071470	9.97	RPTOR MTOR MLST8
20	cellular response to nutrient levels	GO:0031669	9.97	MLST8 MTOR RICTOR RPTOR
21	TORC1 signaling	GO:0038202	9.95	MLST8 MTOR RPTOR
22	activation-induced cell death of T cells	GO:0006924	9.94	RPS6 AKT1
23	anoikis	GO:0043276	9.93	AKT1 MTOR TSC2
24	positive regulation of lipid biosynthetic process	GO:0046889	9.92	RPTOR MTOR MLST8 AKT1
25	regulation of type B pancreatic cell development	GO:2000074	9.91	RHEB AKT1
26	cellular response to decreased oxygen levels	GO:0036294	9.77	PTEN AKT1
27	negative regulation of cell size	GO:0045792	9.76	AKT1S1 MTOR PTEN TSC1
28	positive regulation of pentose-phosphate shunt	GO:1905857	9.73	RPTOR MTOR MLST8
29	negative regulation of TOR signaling	GO:0032007	9.65	TSC2 TSC1 TBC1D7 DEPDC5 AKT1S1
30	TOR signaling	GO:0031929	9.5	RPTOR RPS6KB1 RPS6 RICTOR MTOR MLST8

Molecular functions related to Subependymal Glioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	10.03	RPTOR RPS6 RICTOR RHEB PTEN AKT1
2	RNA polymerase III type 3 promoter sequence-specific DNA binding	GO:0001006	9.62	RPTOR MTOR
3	TFIIIC-class transcription factor complex binding	GO:0001156	9.46	RPTOR MTOR
4	RNA polymerase III type 2 promoter sequence-specific DNA binding	GO:0001003	9.26	RPTOR MTOR
5	RNA polymerase III type 1 promoter sequence-specific DNA binding	GO:0001002	8.92	RPTOR MTOR

Sources

Sources for Subependymal Glioma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: SBP002 MIFTS: 40	Subependymal Glioma Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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