MCID: SBP002
MIFTS: 40

Subependymal Glioma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Subependymal Glioma

MalaCards integrated aliases for Subependymal Glioma:

Name: Subependymal Glioma 11 14 16 71
Mixed Subependymoma-Ependymoma 11
Who Grade I Ependymal Tumor 11
Subependymal Astrocytoma 11
Glioma, Subependymal 43

Classifications:



External Ids:

Disease Ontology 11 DOID:4843
MeSH 43 D018315
NCIt 49 C3795
SNOMED-CT 68 4553004
UMLS 71 C0206725

Summaries for Subependymal Glioma

MalaCards based summary: Subependymal Glioma, also known as mixed subependymoma-ependymoma, is related to tuberous sclerosis 1 and tuberous sclerosis, and has symptoms including headache, motor manifestations and sensory manifestations. An important gene associated with Subependymal Glioma is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Disease and Signal Transduction. The drugs Erlotinib and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and spinal cord, and related phenotypes are Decreased viability and Increased shRNA abundance (Z-score > 2)

Related Diseases for Subependymal Glioma

Diseases related to Subependymal Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)
# Related Disease Score Top Affiliating Genes
1 tuberous sclerosis 1 30.3 TSC2 TSC1
2 tuberous sclerosis 28.7 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RPS6
3 subependymal giant cell astrocytoma 27.9 TSC2 TSC1 TBC1D7 RPTOR RPS6KB1 RICTOR
4 subependymoma 11.2
5 multilocular clear cell renal cell carcinoma 10.3 TSC2 TSC1
6 angiomyolipoma 10.3 TSC2 TSC1 MTOR
7 hepatic angiomyolipoma 10.3 TSC2 TSC1
8 liver lipoma 10.3 TSC2 TSC1
9 perivascular epithelioid cell tumor 10.3 TSC2 TSC1 MTOR
10 exudative vitreoretinopathy 6 10.3 MTOR FKBP1A
11 focal cortical dysplasia, type ii 10.3 TSC2 TSC1 MTOR
12 birt-hogg-dube syndrome 10.3 TSC2 TSC1 MTOR
13 epithelioid type angiomyolipoma 10.3 TSC2 TSC1
14 uterus perivascular epithelioid cell tumor 10.3 TSC2 TSC1 RPS6KB1
15 optic nerve neoplasm 10.3 NF1 MTOR KIAA1549
16 connective tissue benign neoplasm 10.3 TSC2 TSC1 NF1
17 epidural spinal canal neoplasm 10.2 NF1 KIAA1549
18 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2 TSC2 TSC1 PTEN
19 ganglioglioma 10.2 TSC2 TSC1 NF1
20 cowden syndrome 4 10.2 TSC2 PTEN
21 multiple mucosal neuroma 10.2 PTEN NF1
22 megalencephaly 10.2 TBC1D7 PTEN MTOR
23 skin lipoma 10.2 PTEN NF1
24 polycystic kidney disease 1 with or without polycystic liver disease 10.2 TSC2 TSC1 MTOR
25 angiolipoma 10.2 TSC2 TSC1
26 simple partial epilepsy 10.2 KIAA1549 IDH1
27 hypomelanosis of ito 10.2 TSC2 NF1 DEPDC5
28 glioma susceptibility 1 10.2
29 glioma 10.2
30 glial tumor 10.2
31 obstructive hydrocephalus 10.2 TSC2 TSC1 NF1 KIAA1549
32 adult brain stem glioma 10.2 KIAA1549 IDH1
33 thalamic neoplasm 10.2 MYBL1 KIAA1549
34 sturge-weber syndrome 10.2 TSC2 NF1 DEPDC5
35 peutz-jeghers syndrome 10.2 TSC2 TSC1 PTEN
36 pyriform sinus cancer 10.2 RPS6 MTOR EIF4EBP1
37 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 10.2 PTEN MTOR AKT1
38 respiratory system benign neoplasm 10.2 TSC2 PTEN AKT1
39 uterine benign neoplasm 10.2 TSC2 PTEN AKT1
40 reproductive organ benign neoplasm 10.1 TSC2 PTEN AKT1
41 corneal dystrophy, fleck 10.1 TSC2 TSC1 MTOR DEPDC5
42 optic nerve astrocytoma 10.1 TSC2 NF1 IDH1
43 estrogen-receptor positive breast cancer 10.1 PTEN MTOR AKT1
44 thymus gland disease 10.1 PTEN MTOR AKT1
45 kidney benign neoplasm 10.1 TSC2 TSC1 TBC1D7 RHEB MTOR
46 cystic kidney disease 10.1 TSC2 TSC1 MTOR AKT1
47 pervasive developmental disorder 10.1 TSC2 TSC1 PTEN MTOR
48 autosomal dominant polycystic kidney disease 10.1 TSC2 TSC1 MTOR AKT1
49 thymus cancer 10.1 PTEN MTOR AKT1
50 adult oligodendroglioma 10.1 KIAA1549 IDH1

Graphical network of the top 20 diseases related to Subependymal Glioma:



Diseases related to Subependymal Glioma

Symptoms & Phenotypes for Subependymal Glioma

UMLS symptoms related to Subependymal Glioma:


headache; motor manifestations; sensory manifestations

GenomeRNAi Phenotypes related to Subependymal Glioma according to GeneCards Suite gene sharing:

25 (show all 41)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.4 MTOR
2 Decreased viability GR00055-A-2 10.4 MTOR
3 Decreased viability GR00221-A-1 10.4 AKT1 MLST8 MTOR NF1 RHEB RPS6KB1
4 Decreased viability GR00221-A-2 10.4 AKT1 NF1
5 Decreased viability GR00221-A-3 10.4 AKT1
6 Decreased viability GR00221-A-4 10.4 AKT1 MLST8 MTOR NF1
7 Decreased viability GR00249-S 10.4 AKT1 NF1
8 Decreased viability GR00301-A 10.4 RPS6KB1
9 Decreased viability GR00342-S-1 10.4 MTOR
10 Decreased viability GR00342-S-2 10.4 MTOR
11 Decreased viability GR00381-A-1 10.4 RPS6KB1
12 Decreased viability GR00386-A-1 10.4 NF1 RHEB
13 Decreased viability GR00402-S-2 10.4 RPS6KB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.31 RICTOR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-104 10.31 RICTOR
16 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.31 MTOR RHEB
17 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.31 TSC1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-127 10.31 TSC1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.31 PTEN
20 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.31 PTEN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-168 10.31 PTEN
22 Increased shRNA abundance (Z-score > 2) GR00366-A-189 10.31 RICTOR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-211 10.31 RICTOR
24 Increased shRNA abundance (Z-score > 2) GR00366-A-213 10.31 AKT1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-214 10.31 PTEN
26 Increased shRNA abundance (Z-score > 2) GR00366-A-27 10.31 RICTOR
27 Increased shRNA abundance (Z-score > 2) GR00366-A-42 10.31 PTEN TSC1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-58 10.31 RICTOR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-60 10.31 AKT1 MTOR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.31 PTEN RHEB
31 Increased shRNA abundance (Z-score > 2) GR00366-A-66 10.31 PTEN
32 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.31 AKT1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.31 AKT1 MTOR
34 Increased shRNA abundance (Z-score > 2) GR00366-A-87 10.31 PTEN
35 Increased shRNA abundance (Z-score > 2) GR00366-A-93 10.31 PTEN
36 Decreased viability with paclitaxel GR00179-A-1 9.55 MTOR RPS6KB1
37 Decreased viability with paclitaxel GR00179-A-2 9.55 MTOR
38 Decreased viability with paclitaxel GR00179-A-3 9.55 MTOR RPS6KB1
39 Increased cell migration GR00055-A-1 9.26 NF1
40 Increased cell migration GR00055-A-3 9.26 NF1
41 Reduced mammosphere formation GR00396-S 9.17 AKT1S1 EIF4EBP1 MTOR PTEN RHEB RPS6

MGI Mouse Phenotypes related to Subependymal Glioma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 AKT1 AKT1S1 DEPDC5 EIF4EBP1 FKBP1A IDH1
2 growth/size/body region MP:0005378 10.36 AKT1 DEPDC5 EIF4EBP1 FKBP1A IDH1 MLST8
3 nervous system MP:0003631 10.32 AKT1 AKT1S1 DEPDC5 FKBP1A IDH1 MLST8
4 muscle MP:0005369 10.27 AKT1 EIF4EBP1 FKBP1A MTOR NF1 PTEN
5 endocrine/exocrine gland MP:0005379 10.15 AKT1 MTOR MYBL1 NF1 PTEN RHEB
6 liver/biliary system MP:0005370 10.13 AKT1 FKBP1A NF1 PTEN RICTOR RPS6
7 adipose tissue MP:0005375 10.11 AKT1 DEPDC5 EIF4EBP1 KIAA1549 MTOR PTEN
8 embryo MP:0005380 10.1 AKT1 FKBP1A MLST8 MTOR NF1 PTEN
9 cellular MP:0005384 10.1 AKT1 EIF4EBP1 FKBP1A MTOR MYBL1 NF1
10 neoplasm MP:0002006 10.07 AKT1 NF1 PTEN RICTOR RPS6KB1 TSC1
11 cardiovascular system MP:0005385 9.97 AKT1 EIF4EBP1 FKBP1A MLST8 MTOR NF1
12 reproductive system MP:0005389 9.65 AKT1 MYBL1 NF1 PTEN RHEB RICTOR
13 mortality/aging MP:0010768 9.5 AKT1 DEPDC5 EIF4EBP1 FKBP1A IDH1 MLST8

Drugs & Therapeutics for Subependymal Glioma

Drugs for Subependymal Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Erlotinib Approved, Investigational Phase 1 183319-69-9, 183321-74-6 176870
2
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
3
Etanidazole Investigational Phase 1 22668-01-5 3276
4 Liver Extracts Phase 1
5 Protein Kinase Inhibitors Phase 1
6 R04929097 Phase 1
7 Alkylating Agents Phase 1
8 Antineoplastic Agents, Alkylating Phase 1
9 Fluorides Phase 1
10
Imidazole Experimental, Investigational 288-32-4 795
11 Dihydroxyphenylalanine Early Phase 1
12 Protective Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of OSI-774 (NSC 718781) for Solid Tumors in Patients With Hepatic or Renal Dysfunction Completed NCT00030498 Phase 1 erlotinib hydrochloride
2 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
3 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
4 A Pilot Study of Utility of 18F-FDOPA-PET for Neurosurgical Planning and Radiotherapy Target Delineation in Glioma Patients: Biopsy Validation of 18F-FDOPA-PET Uptake and Biodistribution in Brain Tumors Active, not recruiting NCT01165632 Early Phase 1 fluorine F 18 fluorodopa
5 Assessment of Hypoxia in Malignant Gliomas Using EF5 Terminated NCT00430079 etanidazole
6 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452

Search NIH Clinical Center for Subependymal Glioma

Cochrane evidence based reviews: glioma, subependymal

Genetic Tests for Subependymal Glioma

Anatomical Context for Subependymal Glioma

Organs/tissues related to Subependymal Glioma:

MalaCards : Brain, Liver, Spinal Cord

Publications for Subependymal Glioma

Articles related to Subependymal Glioma:

(show all 17)
# Title Authors PMID Year
1
Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis. 62
34416731 2022
2
Clinical features and surgical outcomes of intracranial and spinal cord subependymomas. 62
35148513 2022
3
Multiple Critical Periods for Rapamycin Treatment to Correct Structural Defects in Tsc-1-Suppressed Brain. 62
30467464 2018
4
AMPA receptors promote perivascular glioma invasion via beta1 integrin-dependent adhesion to the extracellular matrix. 62
18957620 2009
5
[Histogenesis of subependymal glioma in Bourneville's tuberous sclerosis]. 62
2346568 1990
6
Human neonatal hydrocephalus. An electron microscopic study of the periventricular tissue. 62
4009275 1985
7
Cerebellar hemangioblastoma and subependymoma: a case report of an unprecedented association. 62
3995811 1985
8
Third ventricle gliomas. Report of 7 cases with benign clinical behaviour. 62
3976445 1985
9
Intraventricular tumors in tuberous sclerosis. 62
3986841 1985
10
Long-term neurological sequelae in achondroplasia. 62
6510432 1984
11
[A rare case of epiphysiolysis in an adult patient with a subependymal astrocytoma. Etiopathogenetic considerations]. 62
6544099 1984
12
Evaluation of the histopathology of brain tumor tissue obtained by ultrasonic aspiration. 62
6633835 1983
13
Subependymal astrocytoma of the septum pellucidum: case report and brief review. 62
277740 1978
14
[Experimental brain tumors produced transplacentally by ethylnitrosourea (IV): ultrastructure studied by using transmission and scanning electron microscope (author's transl)]. 62
708510 1978
15
PAPILLARY SUBEPENDYMAL GLIOSIS (GLIOMATOSIS) ASSOCIATED WITH VON RECKLINGHAUSEN'S DISEASE AND SUBEPENDYMAL GLIOMA. 62
14063111 1963
16
[SUBEPENDYMAL ASTROCYTOMA GIGANTOCELLULARE AND ITS RELATIONSHIP WITH TUBEROUS SCLEROSIS]. 62
14279433 1963
17
Subependymal glioma with hypertension: diagnostic problem. 62
14371747 1955

Variations for Subependymal Glioma

Expression for Subependymal Glioma

Search GEO for disease gene expression data for Subependymal Glioma.

Pathways for Subependymal Glioma

Pathways related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.92 TSC2 RPS6 RICTOR PTEN NF1 MTOR
2 13.92 AKT1 AKT1S1 EIF4EBP1 FKBP1A MLST8 MTOR
3
Show member pathways
13.58 RPTOR RPS6 RHEB MTOR MLST8 IDH1
4
Show member pathways
13.57 AKT1 EIF4EBP1 MTOR NF1 PTEN RPS6
5
Show member pathways
13.53 AKT1 AKT1S1 FKBP1A KIAA1549 MLST8 MTOR
6
Show member pathways
13.48 TSC2 TSC1 RPS6KB1 PTEN MTOR EIF4EBP1
7
Show member pathways
13.27 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RICTOR
8
Show member pathways
13.22 TSC2 RPTOR RICTOR RHEB PTEN MTOR
9
Show member pathways
13.18 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
10
Show member pathways
13.13 TSC2 TSC1 RPTOR RICTOR RHEB PTEN
11
Show member pathways
12.98 TSC2 RPS6KB1 RHEB PTEN MTOR AKT1
12
Show member pathways
12.96 TSC2 TSC1 RPTOR RPS6KB1 RPS6 RHEB
13 12.94 AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
14
Show member pathways
12.92 RPS6KB1 RPS6 MTOR EIF4EBP1 AKT1
15
Show member pathways
12.9 RPS6KB1 RPS6 PTEN MTOR AKT1
16
Show member pathways
12.9 RPS6KB1 RPS6 PTEN MTOR AKT1
17
Show member pathways
12.86 TSC2 RPS6KB1 RHEB PTEN NF1 MTOR
18
Show member pathways
12.84 TSC2 RICTOR PTEN MTOR MLST8 AKT1S1
19
Show member pathways
12.83 TSC2 TSC1 RPTOR RHEB MTOR MLST8
20
Show member pathways
12.76 AKT1 EIF4EBP1 MLST8 MTOR PTEN RHEB
21 12.62 TSC2 RPTOR PTEN IDH1 AKT1
22
Show member pathways
12.52 RPTOR MTOR MLST8 AKT1S1
23
Show member pathways
12.52 AKT1 EIF4EBP1 MTOR PTEN RHEB RPS6
24
Show member pathways
12.51 AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
25
Show member pathways
12.49 RPS6KB1 PTEN MTOR AKT1
26
Show member pathways
12.48 TSC2 TSC1 TBC1D7 AKT1
27
Show member pathways
12.45 RPS6 RICTOR PTEN MTOR MLST8 AKT1
28 12.45 AKT1 AKT1S1 EIF4EBP1 MLST8 MTOR PTEN
29
Show member pathways
12.44 AKT1 MLST8 MTOR RICTOR
30
Show member pathways
12.43 RPS6KB1 PTEN MTOR AKT1S1 AKT1
31
Show member pathways
12.42 TSC2 TSC1 RPTOR RPS6KB1 MTOR EIF4EBP1
32
Show member pathways
12.41 AKT1 AKT1S1 EIF4EBP1 FKBP1A MLST8 MTOR
33
Show member pathways
12.4 TSC2 TSC1 RPTOR RICTOR RHEB PTEN
34
Show member pathways
12.39 AKT1 MTOR RHEB RPS6KB1 TSC2
35
Show member pathways
12.37 RICTOR MTOR MLST8 AKT1
36 12.37 TSC2 TSC1 RHEB PTEN NF1 MTOR
37
Show member pathways
12.36 AKT1 AKT1S1 MLST8 MTOR NF1 PTEN
38
Show member pathways
12.31 TSC2 RPS6KB1 PTEN MTOR EIF4EBP1 AKT1
39
Show member pathways
12.29 TSC2 TSC1 RPTOR RHEB MTOR MLST8
40
Show member pathways
12.27 RPTOR MTOR MLST8 AKT1S1
41 12.23 RPTOR RPS6KB1 PTEN MTOR AKT1
42 12.2 MLST8 MTOR PTEN RHEB RICTOR RPS6
43
Show member pathways
12.18 TSC2 RPS6KB1 RHEB MTOR EIF4EBP1
44
Show member pathways
12.14 AKT1S1 MLST8 MTOR RHEB RPS6 RPS6KB1
45 12.13 TSC2 TSC1 TBC1D7 RHEB PTEN AKT1S1
46 12.13 AKT1 MLST8 MTOR PTEN RHEB RPTOR
47
Show member pathways
12.12 RPS6KB1 RPS6 MTOR AKT1
48 12.11 TSC2 RPTOR PTEN MTOR MLST8 AKT1S1
49 12.08 RPS6KB1 RPS6 EIF4EBP1 AKT1
50 12.05 PTEN MTOR MLST8 AKT1S1

GO Terms for Subependymal Glioma

Cellular components related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 10.51 AKT1 AKT1S1 DEPDC5 EIF4EBP1 FKBP1A IDH1
2 TORC2 complex GO:0031932 9.63 RICTOR MTOR MLST8
3 TSC1-TSC2 complex GO:0033596 9.43 TSC2 TSC1 TBC1D7
4 TORC1 complex GO:0031931 9.17 RPTOR MTOR MLST8 AKT1S1

Biological processes related to Subependymal Glioma according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 10.41 AKT1 MLST8 MTOR PTEN RICTOR RPS6
2 phosphorylation GO:0016310 10.34 AKT1 MLST8 MTOR RICTOR RPS6KB1 RPTOR
3 cellular response to hypoxia GO:0071456 10.22 MLST8 MTOR PTEN RPTOR
4 regulation of GTPase activity GO:0043087 10.19 RICTOR NF1 MTOR MLST8
5 negative regulation of protein kinase activity GO:0006469 10.16 TSC2 NF1 AKT1S1 AKT1
6 negative regulation of autophagy GO:0010507 10.13 RPTOR MTOR MLST8 AKT1
7 response to heat GO:0009408 10.12 RPS6KB1 MTOR AKT1
8 positive regulation of actin filament polymerization GO:0030838 10.12 RICTOR MTOR MLST8
9 phosphatidylinositol 3-kinase signaling GO:0014065 10.11 PTEN NF1 AKT1
10 protein kinase B signaling GO:0043491 10.11 TSC2 RPS6KB1 PTEN AKT1
11 germ cell development GO:0007281 10.1 RPS6KB1 MTOR AKT1
12 positive regulation of cell growth GO:0030307 10.1 RPTOR RICTOR MTOR MLST8 AKT1
13 oligodendrocyte differentiation GO:0048709 10.09 RHEB NF1 MTOR
14 regulation of translation GO:0006417 10.09 TSC1 RPS6KB1 EIF4EBP1 AKT1
15 positive regulation of glycolytic process GO:0045821 10.05 RPTOR MTOR MLST8
16 positive regulation of TOR signaling GO:0032008 10.03 RPTOR RICTOR RHEB MLST8
17 regulation of protein kinase B signaling GO:0051896 10.02 RICTOR PTEN MTOR
18 negative regulation of macroautophagy GO:0016242 10.01 AKT1 MTOR TSC1
19 cellular response to osmotic stress GO:0071470 9.97 RPTOR MTOR MLST8
20 cellular response to nutrient levels GO:0031669 9.97 MLST8 MTOR RICTOR RPTOR
21 TORC1 signaling GO:0038202 9.95 MLST8 MTOR RPTOR
22 activation-induced cell death of T cells GO:0006924 9.94 RPS6 AKT1
23 anoikis GO:0043276 9.93 AKT1 MTOR TSC2
24 positive regulation of lipid biosynthetic process GO:0046889 9.92 RPTOR MTOR MLST8 AKT1
25 regulation of type B pancreatic cell development GO:2000074 9.91 RHEB AKT1
26 cellular response to decreased oxygen levels GO:0036294 9.77 PTEN AKT1
27 negative regulation of cell size GO:0045792 9.76 AKT1S1 MTOR PTEN TSC1
28 positive regulation of pentose-phosphate shunt GO:1905857 9.73 RPTOR MTOR MLST8
29 negative regulation of TOR signaling GO:0032007 9.65 TSC2 TSC1 TBC1D7 DEPDC5 AKT1S1
30 TOR signaling GO:0031929 9.5 RPTOR RPS6KB1 RPS6 RICTOR MTOR MLST8

Molecular functions related to Subependymal Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 10.03 RPTOR RPS6 RICTOR RHEB PTEN AKT1
2 RNA polymerase III type 3 promoter sequence-specific DNA binding GO:0001006 9.62 RPTOR MTOR
3 TFIIIC-class transcription factor complex binding GO:0001156 9.46 RPTOR MTOR
4 RNA polymerase III type 2 promoter sequence-specific DNA binding GO:0001003 9.26 RPTOR MTOR
5 RNA polymerase III type 1 promoter sequence-specific DNA binding GO:0001002 8.92 RPTOR MTOR

Sources for Subependymal Glioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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