MCID: SBL003
MIFTS: 30

Subleukemic Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Subleukemic Leukemia

MalaCards integrated aliases for Subleukemic Leukemia:

Name: Subleukemic Leukemia 12 15
Aleukemic Leukemia Cutis 52 71
Leukemia Subleukemic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12965
UMLS 71 C0887846

Summaries for Subleukemic Leukemia

Disease Ontology : 12 A leukemia that is characterized by the presence of abnormal white blood cells located in peripheral blood, but in which the total number of white blood cells is normal.

MalaCards based summary : Subleukemic Leukemia, also known as aleukemic leukemia cutis, is related to acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) and aleukemic leukemia cutis. An important gene associated with Subleukemic Leukemia is MPO (Myeloperoxidase), and among its related pathways/superpathways are Neuroscience and Hematopoietic cell lineage. Affiliated tissues include peripheral blood, monocytes and myeloid.

Related Diseases for Subleukemic Leukemia

Diseases related to Subleukemic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 214)
# Related Disease Score Top Affiliating Genes
1 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.7 MPO DNTT
2 aleukemic leukemia cutis 12.8
3 aleukemic monocytic leukemia cutis 11.6
4 leukemia, acute lymphoblastic 10.6
5 myeloid leukemia 10.5
6 acute monoblastic leukemia 10.5
7 alveoli adenoma 10.5 SFTPC SCGB1A1
8 leukemia, acute monocytic 10.5
9 monocytic leukemia 10.5
10 bronchial benign neoplasm 10.5 SFTPC SCGB1A1
11 tanycytic ependymoma 10.5 SYP OLIG2
12 glomangiosarcoma 10.5 SYP MLANA
13 sarcomatoid transitional cell carcinoma 10.5 SYP MLANA
14 primary hepatic neuroendocrine carcinoma 10.5 SYP S100B
15 neonatal respiratory failure 10.5 SFTPC SCGB1A1
16 hypoganglionosis 10.5 SYP S100B
17 cerebral primitive neuroectodermal tumor 10.5 SYP S100B
18 benign perivascular tumor 10.5 SYP MLANA
19 leukemia, acute myeloid 10.5
20 rosette-forming glioneuronal tumor 10.5 SYP S100B
21 angiocentric glioma 10.4 SYP S100B
22 spinal cord melanoma 10.4 OLIG2 MLANA
23 lentigo maligna melanoma 10.4 S100B MLANA
24 papillary adenoma 10.4 SYP SFTPC SCGB1A1
25 medullomyoblastoma 10.4 SYP MB
26 cellular ependymoma 10.4 SYP OLIG2
27 acute leukemia 10.4
28 ectopic cushing syndrome 10.4 SYP S100B
29 anaplastic ependymoma 10.4 SYP S100B
30 chordoid meningioma 10.3 SYP S100B
31 supratentorial primitive neuroectodermal tumor 10.3 SYP S100B OLIG2
32 juvenile pilocytic astrocytoma 10.3 SYP S100B OLIG2
33 acute promyelocytic leukemia 10.3
34 t-cell acute lymphoblastic leukemia 10.3
35 vaginal adenoma 10.3 SYP OXT
36 glomangiomatosis 10.3 SYP MLANA MB
37 epithelioid malignant peripheral nerve sheath tumor 10.3 S100B MLANA
38 adrenal cortical carcinoma 10.3 SYP S100B MLANA
39 neurofibroma 10.2 SYP S100B MLANA
40 malignant giant cell tumor of soft parts 10.2 S100B MB CR2
41 leukoencephalopathy, hereditary diffuse, with spheroids 10.2 SYP S100B AIF1
42 vaginal benign neoplasm 10.2 SYP OXT
43 rosai-dorfman disease 10.2 S100B CR2
44 encephalomalacia 10.2 S100B OLIG2 AIF1
45 mast-cell sarcoma 10.2 TNFRSF8 MPO
46 t-cell/histiocyte rich large b cell lymphoma 10.2 TNFRSF8 CR2
47 cerebral degeneration 10.2 SYP RBFOX3 OLIG2
48 mastocytosis, cutaneous 10.2
49 aspergillosis 10.2
50 myelodysplastic syndrome 10.2

Graphical network of the top 20 diseases related to Subleukemic Leukemia:



Diseases related to Subleukemic Leukemia

Symptoms & Phenotypes for Subleukemic Leukemia

Drugs & Therapeutics for Subleukemic Leukemia

Search Clinical Trials , NIH Clinical Center for Subleukemic Leukemia

Genetic Tests for Subleukemic Leukemia

Anatomical Context for Subleukemic Leukemia

The Foundational Model of Anatomy Ontology organs/tissues related to Subleukemic Leukemia:

19
Peripheral Blood

MalaCards organs/tissues related to Subleukemic Leukemia:

40
Monocytes, Myeloid, Skin, T Cells, B Cells, Bone, Neutrophil

Publications for Subleukemic Leukemia

Articles related to Subleukemic Leukemia:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Aleukemic leukemia cutis mimicking urticaria pigmentosa in a patient of T-cell acute lymphoblastic leukemia. 61
31397398 2020
2
Diagnostic challenge of aleukemic leukemia cutis preceding acute myelogenous leukemia: A case report. 61
32477560 2020
3
Chronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia. 61
31808187 2019
4
In reply: Aleukemic leukemia cutis. 61
31066672 2019
5
To the Editor: Aleukemic leukemia cutis. 61
31066671 2019
6
Aleukemic leukemia cutis. 61
30742583 2019
7
Ominous cutaneous presentation of acute myeloid leukemia without peripheral blood involvement upon initial presentation and relapse: case report and literature review. 61
30698150 2018
8
Myeloid Neoplasms. 61
28802501 2017
9
Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome. 61
28376531 2017
10
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. 61
27408353 2016
11
Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course. 61
26863061 2016
12
Pediatric aleukemic leukemia cutis: report of 3 cases and review of the literature. 61
25148106 2015
13
Acute myeloid leukemia 7 years after aleukemic leukemia cutis. 61
24261792 2015
14
Sweet syndrome-like neutrophilic infiltrate as initial presentation of acute myelogenous leukemia. 61
23538898 2014
15
Aleukemic leukemia cutis: an unusual rash in a child. 61
25035690 2014
16
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. 61
23733764 2013
17
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. 61
22573339 2012
18
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. 61
22187541 2011
19
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. 61
21895759 2011
20
Siblings presenting with progressive congenital aleukemic leukemia cutis. 61
21425444 2011
21
Aleukemic leukemia cutis with extensive bone involvement. 61
20708479 2010
22
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. 61
19052694 2009
23
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. 61
18782972 2008
24
Aleukemic leukemia cutis. 61
17456918 2007
25
[Recurrent spontaneous regression of aleukemic leukemia cutis in a girl with acute monocytic leukemia]. 61
16986716 2006
26
[Agranular CD4+/CD56+ haematodermic neoplasm (Precursor haematologic neoplasm)]. 61
16161251 2005
27
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. 61
15540904 2004
28
Therapy-related leukemia cutis: case study of an aggressive disorder. 61
12920571 2003
29
Chronic lower limb ulcer? No--chloroma! 61
15866842 2003
30
[Aleukemic monoblastic leukemia cutis]. 61
14576608 2003
31
Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature. 61
12768324 2003
32
Aleukemic monocytic leukemia cutis. 61
12080951 2002
33
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. 61
11275816 2001
34
Aleukemic leukemia cutis presenting as benign-appearing exanthema. 61
11411915 2001
35
Monocytic aleukemic leukemia cutis. 61
10565632 1999
36
Cutaneous granulocytic sarcoma mimicking immunoblastic large cell lymphoma. 61
10365856 1999
37
Aleukemic leukemia cutis in an adolescent boy. 61
10084909 1999
38
"Aleukemic" granulomatous leukemia cutis. 61
9700385 1998
39
[Monocytic aleukemic leukemia cutis]. 61
9676121 1998
40
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. 61
9555803 1998
41
Aleukemic "leukemia cutis" of monocytic lineage. 61
9146562 1997
42
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. 61
8980276 1997
43
Lymphocytic aleukemic leukemia cutis. 61
8912603 1996
44
Aleukemic monocytic leukemia cutis. 61
8577191 1996
45
Skin involvement in myelogenous leukemia: morphologic and immunophenotypic heterogeneity of skin infiltrates. 61
7824512 1994
46
Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption. 61
2334186 1990
47
Aleukemic leukemia cutis. 61
2406302 1990
48
[Monocytic aleukemic leukemia cutis]. 61
3070080 1988
49
Aleukemic leukemia cutis. 61
3729513 1986
50
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. 61
2943614 1986

Variations for Subleukemic Leukemia

Expression for Subleukemic Leukemia

Search GEO for disease gene expression data for Subleukemic Leukemia.

Pathways for Subleukemic Leukemia

Pathways related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SYP S100B RBFOX3 ENO2 AVP
2 11.33 DNTT CR2 CD24
3 11.03 SYP S100B OLIG2

GO Terms for Subleukemic Leukemia

Cellular components related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 SFTPC SCGB1A1 S100B PTHLH OXT MPO
2 perikaryon GO:0043204 9.26 RBFOX3 GLUL ENO2 AIF1
3 secretory granule GO:0030141 8.92 SCGB1A1 OXT MPO AVP

Biological processes related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.5 SCGB1A1 PTHLH OXT
2 grooming behavior GO:0007625 9.37 OXT AVP
3 maternal behavior GO:0042711 9.26 OXT AVP
4 hyperosmotic salinity response GO:0042538 9.16 OXT AVP
5 maternal aggressive behavior GO:0002125 8.96 OXT AVP
6 response to glucocorticoid GO:0051384 8.92 SCGB1A1 S100B OXT AIF1

Molecular functions related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neurohypophyseal hormone activity GO:0005185 8.62 OXT AVP

Sources for Subleukemic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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