MCID: SBL003
MIFTS: 29

Subleukemic Leukemia

Categories: Blood diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Subleukemic Leukemia

MalaCards integrated aliases for Subleukemic Leukemia:

Name: Subleukemic Leukemia 12 15
Aleukemic Leukemia Cutis 20 71
Leukemia Subleukemic 20

Classifications:



External Ids:

Disease Ontology 12 DOID:12965
UMLS 71 C0887846

Summaries for Subleukemic Leukemia

Disease Ontology : 12 A leukemia that is characterized by the presence of abnormal white blood cells located in peripheral blood, but in which the total number of white blood cells is normal.

MalaCards based summary : Subleukemic Leukemia, also known as aleukemic leukemia cutis, is related to acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) and aleukemic leukemia cutis. An important gene associated with Subleukemic Leukemia is MPO (Myeloperoxidase), and among its related pathways/superpathways are Neuroscience and Hematopoietic cell lineage. Affiliated tissues include peripheral blood, myeloid and skin, and related phenotype is respiratory system.

Related Diseases for Subleukemic Leukemia

Diseases related to Subleukemic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.2 MPO DNTT
2 aleukemic leukemia cutis 11.6
3 aleukemic monocytic leukemia cutis 11.3
4 leukemia 10.7
5 leukemia, acute lymphoblastic 10.5
6 acute monoblastic leukemia 10.5
7 leukemia, acute monocytic 10.4
8 monocytic leukemia 10.4
9 alveoli adenoma 10.4 SFTPC SCGB1A1
10 bronchial benign neoplasm 10.4 SFTPC SCGB1A1
11 neonatal respiratory failure 10.4 SFTPC SCGB1A1
12 leukemia, acute myeloid 10.4
13 sarcomatoid transitional cell carcinoma 10.4 SYP MLANA
14 primary hepatic neuroendocrine carcinoma 10.4 SYP S100B
15 glomangiosarcoma 10.4 SYP MLANA
16 hypoganglionosis 10.4 SYP S100B
17 spinal cord melanoma 10.4 OLIG2 MLANA
18 benign perivascular tumor 10.4 SYP MLANA
19 papillary ependymoma 10.4 SYP S100B
20 rosette-forming glioneuronal tumor 10.4 SYP S100B
21 angiocentric glioma 10.3 SYP S100B
22 lentigo maligna melanoma 10.3 S100B MLANA
23 medullomyoblastoma 10.3 SYP MB
24 acute leukemia 10.3
25 papillary adenoma 10.3 SYP SFTPC SCGB1A1
26 chordoid meningioma 10.3 SYP S100B
27 anaplastic ependymoma 10.3 SYP S100B
28 epithelioid malignant peripheral nerve sheath tumor 10.3 S100B MLANA
29 malignant melanocytic neoplasm of the peripheral nerve sheath 10.3 SYP ENO2
30 anal neuroendocrine tumor 10.3 SYP ENO2
31 optic nerve astrocytoma 10.3 SYP ENO2
32 cerebral neuroblastoma 10.3 SYP ENO2
33 neuronal intestinal dysplasia, type b 10.3 SYP ENO2
34 supratentorial primitive neuroectodermal tumor 10.3 SYP S100B OLIG2
35 lung meningioma 10.3 SYP ENO2
36 sinonasal undifferentiated carcinoma 10.3 SYP ENO2
37 auditory system benign neoplasm 10.3 SYP ENO2
38 papillary tumor of the pineal region 10.3 SYP ENO2
39 small cell carcinoma of the bladder 10.3 SYP ENO2
40 auditory system cancer 10.3 SYP ENO2
41 cloacogenic carcinoma 10.3 SYP ENO2
42 pineal region teratoma 10.3 SYP ENO2
43 intracranial primitive neuroectodermal tumor 10.2 SYP ENO2
44 bile duct mucinous adenocarcinoma 10.2 SYP ENO2
45 nodular prostate 10.2 SYP ENO2
46 vaginal adenoma 10.2 SYP OXT
47 ampulla of vater neoplasm 10.2 SYP ENO2
48 appendix carcinoid tumor 10.2 SYP ENO2
49 carotid body cancer 10.2 SYP ENO2
50 gallbladder small cell carcinoma 10.2 SYP ENO2

Graphical network of the top 20 diseases related to Subleukemic Leukemia:



Diseases related to Subleukemic Leukemia

Symptoms & Phenotypes for Subleukemic Leukemia

MGI Mouse Phenotypes related to Subleukemic Leukemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.17 AVP ENO2 MB OLIG2 PTHLH SCGB1A1

Drugs & Therapeutics for Subleukemic Leukemia

Search Clinical Trials , NIH Clinical Center for Subleukemic Leukemia

Genetic Tests for Subleukemic Leukemia

Anatomical Context for Subleukemic Leukemia

The Foundational Model of Anatomy Ontology organs/tissues related to Subleukemic Leukemia:

19
Peripheral Blood

MalaCards organs/tissues related to Subleukemic Leukemia:

40
Myeloid, Skin

Publications for Subleukemic Leukemia

Articles related to Subleukemic Leukemia:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Aleukemic leukemia cutis mimicking urticaria pigmentosa in a patient of T-cell acute lymphoblastic leukemia. 61
31397398 2020
2
Diagnostic challenge of aleukemic leukemia cutis preceding acute myelogenous leukemia: A case report. 61
32477560 2020
3
Chronic lymphopenia and neutropenia in a dog with large granular lymphocytic leukemia. 61
31808187 2019
4
To the Editor: Aleukemic leukemia cutis. 61
31066671 2019
5
In reply: Aleukemic leukemia cutis. 61
31066672 2019
6
Aleukemic leukemia cutis. 61
30742583 2019
7
Ominous cutaneous presentation of acute myeloid leukemia without peripheral blood involvement upon initial presentation and relapse: case report and literature review. 61
30698150 2018
8
Myeloid Neoplasms. 61
28802501 2017
9
Aleukemic Myeloid Leukemia Cutis with a Kikuchi Disease-Like Inflammatory Pattern in Myelodysplastic Syndrome. 61
28376531 2017
10
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia. 61
27408353 2016
11
Bilateral Aleukemic Myeloid Sarcoma of the Eyelids With Indolent Course. 61
26863061 2016
12
Pediatric aleukemic leukemia cutis: report of 3 cases and review of the literature. 61
25148106 2015
13
Acute myeloid leukemia 7 years after aleukemic leukemia cutis. 61
24261792 2015
14
Sweet syndrome-like neutrophilic infiltrate as initial presentation of acute myelogenous leukemia. 61
23538898 2014
15
Aleukemic leukemia cutis: an unusual rash in a child. 61
25035690 2014
16
Recurrent aleukemic leukemia cutis in a patient with pre-B-cell acute lymphoblastic leukemia. 61
23733764 2013
17
Acute promyelocytic leukemia following aleukemic leukemia cutis harboring NPM/RARA fusion gene. 61
22573339 2012
18
Aleukemic leukemia cutis in a child preceding T-cell acute lymphoblastic leukemia. 61
21895759 2011
19
Aleukemic leukemia cutis manifesting with disseminated nodular eruptions and a plaque preceding acute monocytic leukemia: a case report. 61
22187541 2011
20
Siblings presenting with progressive congenital aleukemic leukemia cutis. 61
21425444 2011
21
Aleukemic leukemia cutis with extensive bone involvement. 61
20708479 2010
22
Spontaneous regression of aleukemic leukemia cutis harboring a NPM/RARA fusion gene in an infant with cutaneous mastocytosis. 61
19052694 2009
23
Aleukemic leukemia cutis preceding acute monocytic leukemia: a case report. 61
18782972 2008
24
Aleukemic leukemia cutis. 61
17456918 2007
25
[Recurrent spontaneous regression of aleukemic leukemia cutis in a girl with acute monocytic leukemia]. 61
16986716 2006
26
[Agranular CD4+/CD56+ haematodermic neoplasm (Precursor haematologic neoplasm)]. 61
16161251 2005
27
Aleukemic leukemia cutis in a patient with Philadelphia chromosome-positive biphenotypic leukemia. 61
15540904 2004
28
Therapy-related leukemia cutis: case study of an aggressive disorder. 61
12920571 2003
29
Chronic lower limb ulcer? No--chloroma! 61
15866842 2003
30
[Aleukemic monoblastic leukemia cutis]. 61
14576608 2003
31
Primary aleukemic myeloid leukemia cutis treated successfully with combination chemotherapy: report of a case and review of the literature. 61
12768324 2003
32
Aleukemic monocytic leukemia cutis. 61
12080951 2002
33
Guess what. B-cell acute lymphoblastic leukemia with aleukemic leukemia cutis. 61
11275816 2001
34
Aleukemic leukemia cutis presenting as benign-appearing exanthema. 61
11411915 2001
35
Monocytic aleukemic leukemia cutis. 61
10565632 1999
36
Cutaneous granulocytic sarcoma mimicking immunoblastic large cell lymphoma. 61
10365856 1999
37
Aleukemic leukemia cutis in an adolescent boy. 61
10084909 1999
38
"Aleukemic" granulomatous leukemia cutis. 61
9700385 1998
39
[Monocytic aleukemic leukemia cutis]. 61
9676121 1998
40
Aleukemic leukemia cutis in a patient with acute lymphoblastic leukemia. 61
9555803 1998
41
Aleukemic "leukemia cutis" of monocytic lineage. 61
9146562 1997
42
Aleukemic leukemia cutis preceding overt acute myeloid leukemia in myelodysplastic syndrome. 61
8980276 1997
43
Lymphocytic aleukemic leukemia cutis. 61
8912603 1996
44
Aleukemic monocytic leukemia cutis. 61
8577191 1996
45
Skin involvement in myelogenous leukemia: morphologic and immunophenotypic heterogeneity of skin infiltrates. 61
7824512 1994
46
Acute myelomonocytic leukemia presenting as a benign-appearing cutaneous eruption. 61
2334186 1990
47
Aleukemic leukemia cutis. 61
2406302 1990
48
[Monocytic aleukemic leukemia cutis]. 61
3070080 1988
49
Aleukemic leukemia cutis. 61
3729513 1986
50
Aleukemic leukemia cutis. An unusual presentation of acute myelomonocytic leukemia. 61
2943614 1986

Variations for Subleukemic Leukemia

Expression for Subleukemic Leukemia

Search GEO for disease gene expression data for Subleukemic Leukemia.

Pathways for Subleukemic Leukemia

Pathways related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.56 SYP S100B RBFOX3 ENO2 AVP
2 11.33 DNTT CR2 CD24
3 11.03 SYP S100B OLIG2

GO Terms for Subleukemic Leukemia

Cellular components related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 SFTPC SCGB1A1 S100B PTHLH OXT MPO
2 perikaryon GO:0043204 9.26 RBFOX3 GLUL ENO2 AIF1
3 secretory granule GO:0030141 8.92 SCGB1A1 OXT MPO AVP

Biological processes related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 female pregnancy GO:0007565 9.54 SCGB1A1 PTHLH OXT
2 response to glucocorticoid GO:0051384 9.33 SCGB1A1 OXT AIF1
3 grooming behavior GO:0007625 9.32 OXT AVP
4 maternal behavior GO:0042711 9.26 OXT AVP
5 hyperosmotic salinity response GO:0042538 8.96 OXT AVP
6 maternal aggressive behavior GO:0002125 8.62 OXT AVP

Molecular functions related to Subleukemic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 PTHLH OXT AVP
2 neurohypophyseal hormone activity GO:0005185 8.62 OXT AVP

Sources for Subleukemic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....