MCID: SBM004
MIFTS: 30

Submandibular Gland Cancer

Categories: Cancer diseases, Endocrine diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Submandibular Gland Cancer

MalaCards integrated aliases for Submandibular Gland Cancer:

Name: Submandibular Gland Cancer 12 15
Malignant Tumor of the Submandibular Gland 12
Malignant Neoplasm of Submaxillary Gland 12
Malignant Tumor of Submandibular Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9173
ICD9CM 34 142.1
NCIt 50 C3526
SNOMED-CT 67 363380002
ICD10 32 C08.0
UMLS 70 C0153360

Summaries for Submandibular Gland Cancer

MalaCards based summary : Submandibular Gland Cancer, also known as malignant tumor of the submandibular gland, is related to submandibular gland disease and parotid gland cancer. An important gene associated with Submandibular Gland Cancer is VPS4A (Vacuolar Protein Sorting 4 Homolog A), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. Affiliated tissues include prostate and salivary gland, and related phenotype is cellular.

Related Diseases for Submandibular Gland Cancer

Diseases related to Submandibular Gland Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 submandibular gland disease 10.3 VPS4B VPS4A
2 parotid gland cancer 10.3 VPS4B ERBB2
3 laryngeal mucoepidermoid carcinoma 10.3 KLK3 ERBB2
4 bladder lateral wall cancer 10.2 KLK3 ERBB2
5 bladder adenocarcinoma 10.2 KLK3 ERBB2
6 breast scirrhous carcinoma 10.2 ERBB2 EGFR
7 breast metaplastic carcinoma 10.1 ERBB2 EGFR
8 breast malignant phyllodes tumor 10.1 ERBB2 EGFR
9 progesterone-receptor negative breast cancer 10.1 ERBB2 EGFR
10 paronychia 10.1 ERBB2 EGFR
11 salivary gland carcinoma 10.1
12 adenoid cystic carcinoma 10.1
13 apocrine adenocarcinoma 10.1 ERBB2 EGFR
14 biliary tract cancer 10.1 ERBB2 EGFR
15 ethmoid sinus adenocarcinoma 10.1 ERBB2 EGFR
16 primary peritoneal carcinoma 10.1 ERBB2 EGFR
17 synchronous bilateral breast carcinoma 10.1 ERBB2 EGFR
18 microglandular adenosis 10.1 ERBB2 EGFR
19 lung non-squamous non-small cell carcinoma 10.1 ERBB2 EGFR
20 gastroesophageal junction adenocarcinoma 10.1 ERBB2 EGFR
21 vulvar disease 10.1 ERBB2 EGFR
22 whiplash 10.1 CCR5 CCL3
23 type 1 diabetes mellitus 22 10.1 CCR5 CCL3
24 periampullary adenocarcinoma 10.1 ERBB2 EGFR
25 chromoblastomycosis 10.1 CCR1 CCL3
26 placental site trophoblastic tumor 10.0 ERBB2 EGFR
27 orofacial granulomatosis 10.0 CCR5 CCL3
28 inflammatory breast carcinoma 10.0 ERBB2 EGFR
29 uterine body mixed cancer 10.0 ERBB2 EGFR
30 prostate cancer 10.0
31 prostatic hypertrophy 10.0
32 facial paralysis 10.0
33 prostatic adenoma 10.0
34 pleomorphic adenoma 10.0
35 mucoepidermoid carcinoma 10.0
36 small cell carcinoma 10.0 KLK3 ERBB2 EGFR
37 suppression of tumorigenicity 12 10.0 KLK3 ERBB2 EGFR
38 gastroesophageal adenocarcinoma 10.0 ERBB2 EGFR
39 transitional cell carcinoma 9.9 KLK3 ERBB2 EGFR
40 rectal disease 9.9 KLK3 EGFR CCR5
41 mesangial proliferative glomerulonephritis 9.9 CCR5 CCR1 CCL3
42 immune-complex glomerulonephritis 9.9 CCR5 CCR1
43 oral lichen planus 9.8 HSPA4 CCR5
44 behcet syndrome 9.7 CCR5 CCR1 CCL3
45 parasitic protozoa infectious disease 9.7 HSPA4 CCR5 CCL3
46 retinitis pigmentosa 61 9.7 HSPA4 HSP90AA1
47 sarcoidosis 1 9.7 HSPA4 CCR5 CCL3
48 amelogenesis imperfecta, type ig 9.7 HSP90AA1 ERBB2 EGFR
49 low grade glioma 9.7 HSPA4 HSP90AA1 ERBB2
50 lobular neoplasia 9.6 HSP90AA1 ERBB2

Graphical network of the top 20 diseases related to Submandibular Gland Cancer:



Diseases related to Submandibular Gland Cancer

Symptoms & Phenotypes for Submandibular Gland Cancer

MGI Mouse Phenotypes related to Submandibular Gland Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.28 CCR1 CCR5 EGFR ERBB2 HSP90AA1 HSPA4

Drugs & Therapeutics for Submandibular Gland Cancer

Search Clinical Trials , NIH Clinical Center for Submandibular Gland Cancer

Genetic Tests for Submandibular Gland Cancer

Anatomical Context for Submandibular Gland Cancer

MalaCards organs/tissues related to Submandibular Gland Cancer:

40
Prostate, Salivary Gland

Publications for Submandibular Gland Cancer

Articles related to Submandibular Gland Cancer:

(show all 23)
# Title Authors PMID Year
1
Submandibular gland cancers: prognostic factors and survival analysis. 61
32211936 2020
2
Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer. 61
30905082 2019
3
Trastuzumab-Based Combination Chemotherapy in Patients with Human Epidermal Growth Factor Receptor-2-Positive Metastatic Carcinoma ex Pleomorphic Adenoma. 61
30687059 2018
4
Nodal Stage: Is It a Prognostic Factor for Submandibular Gland Cancer? 61
29227792 2018
5
Submandibular gland cancer: Specific features and treatment considerations. 61
29083518 2018
6
A Case of Advanced Submandibular Gland Cancer in Which Increased Prostate-Specific Antigen and Multiple Bone Metastases Wrongly Suggested Concurrent Prostate Cancer. 61
29430238 2017
7
Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review. 61
25962319 2015
8
Robotic-assisted neck dissection in submandibular gland cancer: preliminary report. 61
23597950 2013
9
[A case of submandibular gland cancer in elderly patients showed significant effect by S-1 and intravenous docetaxel chemotherapy concurrent with radiotherapy]. 61
20948259 2010
10
Prognostic factors and outcome analysis of submandibular gland cancer: a clinical audit. 61
20538399 2010
11
Mixed malignant tumor of the submandibular gland. 61
20187518 2009
12
First clinical case of boron neutron capture therapy for head and neck malignancies using 18F-BPA PET. 61
16721735 2006
13
Survival and prognosis for cancer of the submandibular gland. 61
15085507 2004
14
[Prophylactic neck dissection for submandibular gland cancer]. 61
14513779 2003
15
[Surgical treatment for pulmonary metastasis from submandibular gland cancer]. 61
12607254 2003
16
Interaction between 2-ethoxybenzoic acid (EBA) and eugenol, and related changes in cytotoxicity. 61
12508044 2003
17
Carcinoma of the parotid and submandibular glands--a study of survival in 2465 patients. 61
12167424 2002
18
[Effects of TNM extension and histopathological type of the tumor on long-term survival rates of parotid and submandibular gland cancer]. 61
9279358 1997
19
[TNM classification system in cancer of the submandibular gland--a comprehensive retrospective study of 271 primary cases]. 61
1545308 1992
20
Spindle cell mucoepidermoid carcinoma of submandibular gland. 61
3945080 1986
21
[A monstrous and histologically curious malignant tumor of the submandibular gland]. 61
6713558 1984
22
Fibrous histiocytoma of the head and neck: A case report. 61
215860 1978
23
In vitro metabolism of estrone 2,4,6,7-3H and 4-androstene-3,17-dione-1,2-3H in submandibular gland and submandibular gland cancer tumor. 61
4421580 1974

Variations for Submandibular Gland Cancer

Expression for Submandibular Gland Cancer

Search GEO for disease gene expression data for Submandibular Gland Cancer.

Pathways for Submandibular Gland Cancer

Pathways related to Submandibular Gland Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 HSP90AA1 ERBB2 EGFR CCR5 CCR1 CCL3
2
Show member pathways
12.99 HSP90AA1 ERBB2 EGFR CCR5 CCR1 CCL3
3
Show member pathways
12.58 KLK3 HSP90AA1 ERBB2 EGFR
4 12.52 KLK3 HSP90AA1 ERBB2 EGFR
5
Show member pathways
12.41 HSPA4 HSP90AA1 CCR5 CCR1 CCL3
6
Show member pathways
12.03 HSP90AA1 ERBB2 EGFR
7
Show member pathways
12.02 HSP90AA1 ERBB2 EGFR
8 12.02 VPS4B VPS4A EGFR CCR5
9 11.97 HMGB1 CCR5 CCR1
10
Show member pathways
11.73 HSP90AA1 ERBB2 EGFR
11
Show member pathways
11.49 VPS4B VPS4A HSP90AA1 HMGB1
12
Show member pathways
11.21 HSP90AA1 ERBB2 EGFR CCR5 CCR1
13 11.04 ERBB2 EGFR
14 11.02 CCR5 CCR1 CCL3
15 11 ERBB2 EGFR
16 10.37 HSPA4 HSP90AA1

GO Terms for Submandibular Gland Cancer

Cellular components related to Submandibular Gland Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 VPS4B VPS4A IDE HSPA4 HSP90AA1 HMGB1
2 endosome membrane GO:0010008 9.56 VPS4B VPS4A ERBB2 EGFR
3 cell surface GO:0009986 9.55 IDE HSP90AA1 HMGB1 EGFR CCR5
4 endosome GO:0005768 9.1 VPS4B VPS4A HMGB1 ERBB2 EGFR CCR5

Biological processes related to Submandibular Gland Cancer according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 HMGB1 CCR5 CCR1 CCL3
2 cell surface receptor signaling pathway GO:0007166 9.91 ERBB2 EGFR CCR5 CCR1
3 viral process GO:0016032 9.91 IDE HSP90AA1 HMGB1 EGFR CCR5
4 cytokine-mediated signaling pathway GO:0019221 9.87 HSP90AA1 CCR5 CCR1 CCL3
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 HMGB1 CCR5 CCR1
6 MAPK cascade GO:0000165 9.84 ERBB2 EGFR CCR5 CCL3
7 calcium ion transport GO:0006816 9.83 CCR5 CCR1 CCL3
8 cell chemotaxis GO:0060326 9.77 CCR5 CCR1 CCL3
9 calcium-mediated signaling GO:0019722 9.76 CCR5 CCR1 CCL3
10 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.73 HMGB1 EGFR CCR1 CCL3
11 positive regulation of protein phosphorylation GO:0001934 9.71 HSP90AA1 HMGB1 ERBB2 EGFR
12 chemokine-mediated signaling pathway GO:0070098 9.7 CCR5 CCR1 CCL3
13 regulation of cell motility GO:2000145 9.69 ERBB2 EGFR
14 regulation of ERK1 and ERK2 cascade GO:0070372 9.69 ERBB2 EGFR
15 multivesicular body assembly GO:0036258 9.68 VPS4B VPS4A
16 viral life cycle GO:0019058 9.68 VPS4B VPS4A
17 nucleus organization GO:0006997 9.68 VPS4B VPS4A
18 activation of innate immune response GO:0002218 9.68 HSP90AA1 HMGB1
19 positive regulation of calcium ion transport GO:0051928 9.67 CCR1 CCL3
20 chaperone-mediated protein complex assembly GO:0051131 9.67 HSPA4 HSP90AA1
21 regulation of nitric-oxide synthase activity GO:0050999 9.66 HSP90AA1 EGFR
22 viral budding via host ESCRT complex GO:0039702 9.66 VPS4B VPS4A
23 positive regulation of monocyte chemotaxis GO:0090026 9.65 HMGB1 CCR1
24 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 9.65 VPS4B VPS4A
25 response to lipid GO:0033993 9.64 VPS4B EGFR
26 midbody abscission GO:0061952 9.64 VPS4B VPS4A
27 negative regulation of bone mineralization GO:0030502 9.63 CCR1 CCL3
28 positive regulation of exosomal secretion GO:1903543 9.62 VPS4B VPS4A
29 response to cholesterol GO:0070723 9.62 CCR5 CCL3
30 positive regulation of protein kinase B signaling GO:0051897 9.62 HSP90AA1 ERBB2 EGFR CCL3
31 ESCRT III complex disassembly GO:1904903 9.61 VPS4B VPS4A
32 positive regulation of viral release from host cell GO:1902188 9.6 VPS4B VPS4A
33 signaling GO:0023052 9.58 CCR5 CCL3
34 positive regulation of viral life cycle GO:1903902 9.56 VPS4B VPS4A
35 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.55 CCR5 CCL3
36 negative regulation of ERBB signaling pathway GO:1901185 9.49 ERBB2 EGFR
37 viral release from host cell GO:0019076 9.48 VPS4B VPS4A
38 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:0090611 9.46 VPS4B VPS4A
39 chemotaxis GO:0006935 9.46 HMGB1 CCR5 CCR1 CCL3
40 protein import into mitochondrial outer membrane GO:0045040 9.37 HSPA4 HSP90AA1
41 late endosomal microautophagy GO:0061738 9.26 VPS4B VPS4A
42 ERBB2 signaling pathway GO:0038128 9.13 HSP90AA1 ERBB2 EGFR
43 dendritic cell chemotaxis GO:0002407 8.8 HMGB1 CCR5 CCR1

Molecular functions related to Submandibular Gland Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 9.87 VPS4B VPS4A IDE HSPA4 HSP90AA1 ERBB2
2 protein-containing complex binding GO:0044877 9.73 VPS4B VPS4A IDE EGFR
3 protein C-terminus binding GO:0008022 9.71 VPS4B VPS4A ERBB2
4 identical protein binding GO:0042802 9.7 VPS4B IDE HSP90AA1 ERBB2 EGFR CCR5
5 ATPase activity GO:0016887 9.56 VPS4B VPS4A IDE HSP90AA1
6 virus receptor activity GO:0001618 9.54 IDE EGFR CCR5
7 phosphatidylinositol phospholipase C activity GO:0004435 9.52 CCR5 CCR1
8 C-C chemokine binding GO:0019957 9.51 CCR5 CCR1
9 ATP binding GO:0005524 9.5 VPS4B VPS4A IDE HSPA4 HSP90AA1 ERBB2
10 C-C chemokine receptor activity GO:0016493 9.49 CCR5 CCR1
11 chemokine receptor activity GO:0004950 9.48 CCR5 CCR1
12 DNA polymerase binding GO:0070182 9.46 HSP90AA1 HMGB1
13 nitric-oxide synthase regulator activity GO:0030235 9.4 HSP90AA1 EGFR
14 chemokine (C-C motif) ligand 5 binding GO:0071791 8.62 CCR5 CCR1

Sources for Submandibular Gland Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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