MCID: SBM003
MIFTS: 23

Submandibular Gland Disease

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Submandibular Gland Disease

MalaCards integrated aliases for Submandibular Gland Disease:

Name: Submandibular Gland Disease 12 15
Submandibular Gland Diseases 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12897
MeSH 44 D013364
UMLS 70 C0038557

Summaries for Submandibular Gland Disease

MalaCards based summary : Submandibular Gland Disease, also known as submandibular gland diseases, is related to igg4-related submandibular gland disease and sialadenitis. An important gene associated with Submandibular Gland Disease is SSB (Small RNA Binding Exonuclease Protection Factor La), and among its related pathways/superpathways are CXCR4-mediated signaling events and Budding and maturation of HIV virion. Affiliated tissues include prostate, and related phenotypes are hematopoietic system and immune system

Related Diseases for Submandibular Gland Disease

Diseases related to Submandibular Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 igg4-related submandibular gland disease 11.2
2 sialadenitis 9.9
3 sialolithiasis 9.9
4 selective immunoglobulin deficiency disease 9.9 SLAMF7 SH2D1B
5 submandibular gland cancer 9.8 VPS4B VPS4A
6 lymphoid interstitial pneumonia 9.8 TGFB1 SSB
7 dysgammaglobulinemia 9.8 SLAMF7 SH2D1B

Graphical network of the top 20 diseases related to Submandibular Gland Disease:



Diseases related to Submandibular Gland Disease

Symptoms & Phenotypes for Submandibular Gland Disease

MGI Mouse Phenotypes related to Submandibular Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 ENTPD1 SH2D1B SLAMF7 SSB TGFB1 VPS4A
2 immune system MP:0005387 9.17 ENTPD1 SH2D1B SLAMF7 SSB TGFB1 VPS4A

Drugs & Therapeutics for Submandibular Gland Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 ROLE OF Gray Scale and Doppler Ultrasound in Diagnosis of Parotid and Submandibular Gland Diseases Unknown status NCT03746730

Search NIH Clinical Center for Submandibular Gland Disease

Cochrane evidence based reviews: submandibular gland diseases

Genetic Tests for Submandibular Gland Disease

Anatomical Context for Submandibular Gland Disease

MalaCards organs/tissues related to Submandibular Gland Disease:

40
Prostate

Publications for Submandibular Gland Disease

Articles related to Submandibular Gland Disease:

(show all 24)
# Title Authors PMID Year
1
Rates of sialoendoscopy and sialoadenectomy in 5,111 adults with private insurance. 61
30556133 2019
2
Operative technique for benign submandibular gland mass without identifying the mandibular branch of the facial nerve. 61
29789194 2018
3
Robotic surgery for submandibular gland resection through a trans-hairline approach: The first human series and comparison with applicable approaches. 61
29356204 2018
4
Robot-assisted submandibular gland excision via modified facelift incision. 61
28944219 2017
5
Pharyngocutaneous Fistula as a Rare Late Postoperative Complication Following Submandibulectomy: A Case Report. 61
28819623 2017
6
Multimodal ultrasonographic algorithm in the differentiation of submandibular masses. 61
28084145 2017
7
Minimally invasive video-assisted submandibular sialadenectomy: surgical technique and results from two institutions. 61
26487240 2016
8
T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease. 61
24390219 2014
9
Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease. 61
23625388 2014
10
Epithelial Na+ channel (ENaC) expression in obstructive sialadenitis of the submandibular gland. 61
20926064 2011
11
Surgical management of submandibulary gland diseases: ten years of experience. 61
21682080 2011
12
[The value of imaging methods in diagnosis of submandibular gland diseases]. 61
19417985 2009
13
Submandibular gland excision: 15 years of experience. 61
17448847 2007
14
Minimally invasive endoscopic resection of the submandibular gland: a new approach. 61
16933310 2006
15
[CT and ultrasonographic findings in patients with carotidynia]. 61
15765730 2005
16
Submandibular gland aplasia and progressive dental caries: a case report. 61
12587773 2002
17
[Evaluation of normal submandibular gland function by sialo-scintigraphy]. 61
11834166 1999
18
Anterior facial vein and submandibular gland together: predicting the histology of submandibular masses with CT or MR imaging. 61
9680573 1998
19
The surgical management of submandibular gland disease. 61
11905349 1998
20
Wegener's granulomatosis presenting as prostate and submandibular gland disease. 61
9306514 1997
21
Quantitative analysis of the submandibular gland using computed tomography. 61
9446980 1996
22
The use of sialodochoplasty in the treatment of benign inflammatory obstructive submandibular gland disease. 61
3683054 1987
23
Superior laryngeal neuralgia. 61
6167688 1981
24
A different approach to the management of submandibular gland disease. 61
1198779 1975

Variations for Submandibular Gland Disease

Expression for Submandibular Gland Disease

Search GEO for disease gene expression data for Submandibular Gland Disease.

Pathways for Submandibular Gland Disease

Pathways related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 VPS4B VPS4A
2
Show member pathways
10.5 VPS4B VPS4A

GO Terms for Submandibular Gland Disease

Cellular components related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Flemming body GO:0090543 8.62 VPS4B VPS4A

Biological processes related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 macroautophagy GO:0016236 9.57 VPS4B VPS4A
2 endosomal transport GO:0016197 9.56 VPS4B VPS4A
3 mitotic metaphase plate congression GO:0007080 9.55 VPS4B VPS4A
4 multivesicular body assembly GO:0036258 9.54 VPS4B VPS4A
5 viral life cycle GO:0019058 9.52 VPS4B VPS4A
6 nucleus organization GO:0006997 9.51 VPS4B VPS4A
7 viral budding via host ESCRT complex GO:0039702 9.49 VPS4B VPS4A
8 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 9.48 VPS4B VPS4A
9 midbody abscission GO:0061952 9.46 VPS4B VPS4A
10 positive regulation of exosomal secretion GO:1903543 9.43 VPS4B VPS4A
11 positive regulation of histone deacetylation GO:0031065 9.4 ZBTB7B TGFB1
12 ESCRT III complex disassembly GO:1904903 9.37 VPS4B VPS4A
13 positive regulation of viral release from host cell GO:1902188 9.32 VPS4B VPS4A
14 positive regulation of viral life cycle GO:1903902 9.26 VPS4B VPS4A
15 viral release from host cell GO:0019076 9.16 VPS4B VPS4A
16 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway GO:0090611 8.96 VPS4B VPS4A
17 late endosomal microautophagy GO:0061738 8.62 VPS4B VPS4A

Molecular functions related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 8.8 VPS4B VPS4A TGFB1

Sources for Submandibular Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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