MCID: SBM003
MIFTS: 25

Submandibular Gland Disease

Categories: Endocrine diseases, Oral diseases

Aliases & Classifications for Submandibular Gland Disease

MalaCards integrated aliases for Submandibular Gland Disease:

Name: Submandibular Gland Disease 12 15
Submandibular Gland Diseases 45 74

Classifications:



External Ids:

Disease Ontology 12 DOID:12897
MeSH 45 D013364
UMLS 74 C0038557

Summaries for Submandibular Gland Disease

MalaCards based summary : Submandibular Gland Disease, also known as submandibular gland diseases, is related to igg4-related submandibular gland disease and bladder disease. An important gene associated with Submandibular Gland Disease is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include prostate, salivary gland and bone, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Submandibular Gland Disease

Graphical network of the top 20 diseases related to Submandibular Gland Disease:



Diseases related to Submandibular Gland Disease

Symptoms & Phenotypes for Submandibular Gland Disease

GenomeRNAi Phenotypes related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.8 ERBB2 TGFB1
2 Decreased viability with paclitaxel GR00179-A-3 8.8 TGFB1

Drugs & Therapeutics for Submandibular Gland Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Role of US,Doppler in Major Salivary Gland Diseases Not yet recruiting NCT03746730

Search NIH Clinical Center for Submandibular Gland Disease

Cochrane evidence based reviews: submandibular gland diseases

Genetic Tests for Submandibular Gland Disease

Anatomical Context for Submandibular Gland Disease

MalaCards organs/tissues related to Submandibular Gland Disease:

42
Prostate, Salivary Gland, Bone

Publications for Submandibular Gland Disease

Articles related to Submandibular Gland Disease:

# Title Authors Year
1
Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease. ( 23625388 )
2014
2
The surgical management of submandibular gland disease. ( 11905349 )
1998
3
Wegener's granulomatosis presenting as prostate and submandibular gland disease. ( 9306514 )
1997
4
The use of sialodochoplasty in the treatment of benign inflammatory obstructive submandibular gland disease. ( 3683054 )
1987
5
A different approach to the management of submandibular gland disease. ( 1198779 )
1975

Variations for Submandibular Gland Disease

Expression for Submandibular Gland Disease

Search GEO for disease gene expression data for Submandibular Gland Disease.

Pathways for Submandibular Gland Disease

Pathways related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 ERBB2 KLK3 TGFB1
2 12.06 ERBB2 KLK3 TGFB1
3
Show member pathways
12.03 ERBB2 TGFB1
4
Show member pathways
12 ERBB2 TGFB1
5 11.74 ERBB2 TGFB1
6 11.43 ERBB2 TGFB1
7 11.18 ERBB2 TGFB1
8 11.18 ERBB2 TGFB1
9
Show member pathways
11.09 ERBB2 TGFB1
10
Show member pathways
10.96 ERBB2 KLK3 TGFB1
11 10.84 ERBB2 TGFB1
12 10.43 ERBB2 TGFB1

GO Terms for Submandibular Gland Disease

Cellular components related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 KLK3 TGFB1

Biological processes related to Submandibular Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.46 ERBB2 TGFB1
2 MAPK cascade GO:0000165 9.43 ERBB2 TGFB1
3 positive regulation of protein phosphorylation GO:0001934 9.4 ERBB2 TGFB1
4 positive regulation of protein kinase B signaling GO:0051897 9.37 ERBB2 TGFB1
5 wound healing GO:0042060 9.32 ERBB2 TGFB1
6 positive regulation of epithelial cell proliferation GO:0050679 9.26 ERBB2 TGFB1
7 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.18 TGFB1
8 positive regulation of MAP kinase activity GO:0043406 9.16 ERBB2 TGFB1
9 cellular response to growth factor stimulus GO:0071363 8.96 ERBB2 TGFB1
10 myelination GO:0042552 8.62 ERBB2 TGFB1

Sources for Submandibular Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....