Submucosal Cleft Palate disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Submucosal Cleft Palate

MalaCards integrated aliases for Submucosal Cleft Palate:

Name: Submucosal Cleft Palate ⁶⁰

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³⁵

Congenital malformations, deformations and chromosomal abnormalities

Cleft lip and cleft palate

Cleft palate

Cleft palate, unspecified

Orphanet: ⁶⁰

Developmental anomalies during embryogenesis

External Ids:

ICD10 via Orphanet ³⁵ Q35.9

Orphanet ⁶⁰ ORPHA155878

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Summaries for Submucosal Cleft Palate

MalaCards based summary : Submucosal Cleft Palate is related to cleft palate, isolated and schilbach-rott syndrome. An important gene associated with Submucosal Cleft Palate is UBB (Ubiquitin B). The drug Cocaine has been mentioned in the context of this disorder. Related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

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Related Diseases for Submucosal Cleft Palate

Diseases related to Submucosal Cleft Palate via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	cleft palate, isolated	29.9	GRHL3 UBB
2	schilbach-rott syndrome	11.5
3	otopalatodigital syndrome, type ii	11.3
4	hypospadias	10.0
5	uvula, bifid	9.7	GRHL3 UBB
6	cleft hard palate	9.7	GRHL3 UBB
7	cleft soft palate	9.6	GRHL3 UBB

Graphical network of the top 20 diseases related to Submucosal Cleft Palate:

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Symptoms & Phenotypes for Submucosal Cleft Palate

GenomeRNAi Phenotypes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Negative genetic interaction between PTTG1-/- and PTTG1+/+	GR00255-A-4	8.62	GRHL3 UBB

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Drugs & Therapeutics for Submucosal Cleft Palate

Drugs for Submucosal Cleft Palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Cocaine

Approved, Illicit

Not Applicable

50-36-2

446220 5760

Synonyms:

(−)-cocaine

(-)-Cocaine

(-)-Cocaine base

(1R,2R,3S,5S)-2-(methoxycarbonyl)tropan-3-yl benzoate

(1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate

(R)-Cocaine

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate, methyl ester

[1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

[1R-(exo,exo)]-3-(Benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid, methyl ester

1-Cocaine

1i7z

1q72

2beta-Carbomethoxy-3beta-benzoxytropane

2-beta-Carbomethoxy-3-beta-benzoxytropane

2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylate benzoate (ester)

2-Methyl-3beta-hydroxy-1alphah,5alphah-tropane-2beta-carboxylic acid benzoic acid (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylate benzoate (ester)

2-Methyl-3b-hydroxy-1alphah,5alphah-tropane-2b-carboxylic acid benzoic acid (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylate benzoate (ester)

2-Methyl-3β-hydroxy-1alphah,5alphah-tropane-2β-carboxylic acid benzoic acid (ester)

2-methyl-3β-hydroxy-1αH,5αH-tropane-2β-carboxylate benzoate (ester)

3beta-Hydroxy-2beta-tropanecarboxylic acid methyl ester benzoate (ester)

3-Tropanylbenzoate-2-carboxylic acid methyl ester

50-36-2

53-21-4 (hydrochloride)

610089_ALDRICH

610089_FLUKA

AC-16037

AC1L1EK2

AC1L1L2T

AC1L3U2D

AC1L9JBL

AC-20208

Allococaine

Allopseudococaine

Badrock

Bazooka

b-Cocain

Benzoylethylecgonine

Benzoylmethylecgonine

Bernice

Bernice [Street Name]

Bernies

beta-Cocain

Beta-Cocain

Blast

Blizzard

Blow

Blow [Street Name]

Bouncing Powder

Bump

Burese

C" Carrie

C01416

C8912_SIGMA

Cabello

Candy

Carrie

Caviar

Cecil

Cecil [Street Name]

Charlie

CHEBI:27958

Chicken Scratch

Cholly

CID11779748

CID2826

CID446220

CID5760

COC

Coca

Cocain

Cocaina

cocaine

Cocaine

Cocaine (TN)

Cocaine (USP)

Cocaine [BAN]

Cocaine free base

Cocaine Free Base

Cocaine HCL

Cocaine hydrochloride

Cocaine solution

Cocaine-M

cocainum

Cocainum

Cocktail

Coke

Cola

Corine

CPD-9776

Crack

Crack cocaine

D00110

Dama blanca

Dama Blanca

DB00907

DEA No. 9041

Delcaine

Depsococaine

Dextrocaine

DivK1c_000975

d-Pseudococaine

D-pseudococaine

Dust

Ecgonine methyl ester benzoate

Ecgonine methyl ester benzoate solution

Ecgonine, methyl ester, benzoate (ester)

EINECS 200-032-7

Eritroxilina

Erytroxylin

Flake

Flake [Street Name]

Flex

Florida Snow

Foo Foo

Freeze

Girl

Girl [Street Name]

Gold dust

Gold Dust

Gold dust [Street Name]

Goofball

Green gold

Green Gold

G-Rock

Happy dust

Happy Dust

Happy dust [Street Name]

Happy powder

Happy Powder

Happy trails

Happy Trails

HCL, Cocaine

Heaven

Hell

HSDB 6469

Hydrochloride, cocaine

IDI1_000975

Isocaine

Isococain

Isococaine

Jam

KBio1_000975

Kibbles n' Bits

Kibbles N' Bits

Kokain

Kokan

Kokayeen

L000836

Lady

Lady [Street Name]

l-Cocain

L-Cocain

L-Cocaine

Leaf

LS-157759

methyl (1S,4R,5R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl (3S,4R)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

Methyl [1R-(exo,exo)]-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid

Methyl 3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate

methyl 3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate

Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester)

Methyl benzoylecgonine

Methyl Benzoylecgonine

MLS002320697

MolPort-002-535-520

MolPort-003-937-722

Moonrocks

NCGC00159467-02

nchembio.284-comp4

Neurocaine

NINDS_000975

Nose candy

Pimp's drug

Pimp's Drug

Prime Time

Pseudoallococaine

Pseudococaine

Rock

Rock [Street Name]

Sleighride

SMR001338843

Snort

Snow

Snow (birds)

Star dust

Star Dust

Star-spangled powder

Star-Spangled Powder

STOCK1N-68258

Sugar

Sweet Stuff

Toke

Toot

Toot [Street Name]

Trails

UNII-I5Y540LHVR

White girl or lady

Yeyo

Zip

β-cocain

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal	Completed	NCT00773994	Not Applicable
2	Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate	Not yet recruiting	NCT03868891	Not Applicable

Search NIH Clinical Center for Submucosal Cleft Palate

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Genetic Tests for Submucosal Cleft Palate

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Anatomical Context for Submucosal Cleft Palate

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Publications for Submucosal Cleft Palate

Articles related to Submucosal Cleft Palate:

#	Title	Authors	Year
1	Perforation With Submucosal Cleft Palate in a Previously Undiagnosed Adult Patient. ( 27526237 )	Evin A.9.G....Tosun Z.	2016
2	Congenital Fistula of the Hard Palate With Submucosal Cleft Palate. ( 27391507 )	Lu Y....Han W.	2016
3	Powered instrumentation for transnasal endoscopic partial adenoidectomy in children with submucosal cleft palate. ( 24373587 )	Askar S.M....Quriba A.S.	2014
4	An unusual accessory mandible and a submucosal cleft palate-a case report and review of the literature. ( 22404912 )	Borzabadi-Farahani A....Yen S.L.	2013
5	Endoscopic adenoidectomy in children with submucosal cleft palate. ( 16911833 )	Stern Y....Yaniv E.	2006
6	Ocular hypotelorism, submucosal cleft palate, and hypospadias: a new autosomal dominant syndrome. ( 3149147 )	Schilbach U....Rott H.D.	1988
7	Effects of maxillary advancement on the speech of a submucosal cleft palate patient. ( 267529 )	Bringham G.P....Peterson-Falzone S.J.	1977

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Genes for Submucosal Cleft Palate

Genes related to Submucosal Cleft Palate (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	UBB	Ubiquitin B	Protein Coding	25	Candidate gene tested ⁶⁰
2	GRHL3	Grainyhead Like Transcription Factor 3	Protein Coding	25	Susceptibility factor ⁶⁰

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Variations for Submucosal Cleft Palate

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Expression for Submucosal Cleft Palate

Search GEO for disease gene expression data for Submucosal Cleft Palate.

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Pathways for Submucosal Cleft Palate

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GO Terms for Submucosal Cleft Palate

Biological processes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	8.62	GRHL3 UBB

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Sources for Submucosal Cleft Palate

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia