MCID: SBM006
MIFTS: 15

Submucosal Cleft Palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Submucosal Cleft Palate

MalaCards integrated aliases for Submucosal Cleft Palate:

Name: Submucosal Cleft Palate 59

Classifications:



External Ids:

ICD10 via Orphanet 34 Q35.9
Orphanet 59 ORPHA155878

Summaries for Submucosal Cleft Palate

MalaCards based summary : Submucosal Cleft Palate is related to cleft palate, isolated and schilbach-rott syndrome. An important gene associated with Submucosal Cleft Palate is GRHL3 (Grainyhead Like Transcription Factor 3). Affiliated tissues include heart and bone, and related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Submucosal Cleft Palate

Diseases related to Submucosal Cleft Palate via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 cleft palate, isolated 29.6 UBB GRHL3
2 schilbach-rott syndrome 12.0
3 otopalatodigital syndrome, type ii 11.4
4 palatopharyngeal incompetence 10.2
5 chromosome 2q35 duplication syndrome 10.0
6 blepharophimosis 10.0
7 klippel-feil syndrome 10.0
8 hypospadias 10.0
9 hard palate cancer 10.0
10 overgrowth syndrome 10.0
11 cleft hard palate 9.5 UBB GRHL3
12 uvula, bifid 9.5 UBB GRHL3
13 cleft soft palate 9.4 UBB GRHL3

Graphical network of the top 20 diseases related to Submucosal Cleft Palate:



Diseases related to Submucosal Cleft Palate

Symptoms & Phenotypes for Submucosal Cleft Palate

GenomeRNAi Phenotypes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.62 GRHL3 UBB

Drugs & Therapeutics for Submucosal Cleft Palate

Search Clinical Trials , NIH Clinical Center for Submucosal Cleft Palate

Genetic Tests for Submucosal Cleft Palate

Anatomical Context for Submucosal Cleft Palate

MalaCards organs/tissues related to Submucosal Cleft Palate:

41
Heart, Bone

Publications for Submucosal Cleft Palate

Articles related to Submucosal Cleft Palate:

(show all 33)
# Title Authors PMID Year
1
Partial Adenoidectomy in Patients With Palatal Abnormalities. 38
31299813 2019
2
Incidence of bifid uvula and its relationship to submucous cleft palate and a family history of oral cleft in the Brazilian population. 38
28886940 2018
3
Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. 38
28081210 2017
4
Perforation With Submucosal Cleft Palate in a Previously Undiagnosed Adult Patient. 38
27526237 2016
5
Congenital Fistula of the Hard Palate With Submucosal Cleft Palate. 38
27391507 2016
6
19q13.32 microdeletion syndrome: three new cases. 38
25230004 2014
7
Microdeletions involving chromosomes 12 and 22 associated with syndromic Duane retraction syndrome. 38
24865192 2014
8
Surgical considerations in 22Q11.2 deletion syndrome. 38
24607194 2014
9
Powered instrumentation for transnasal endoscopic partial adenoidectomy in children with submucosal cleft palate. 38
24373587 2014
10
A 25-year review of cases with submucous cleft palate. 38
23707152 2013
11
An unusual accessory mandible and a submucosal cleft palate-a case report and review of the literature. 38
22404912 2013
12
Haploinsufficiency of STK11 and neighboring genes cause a contiguous gene syndrome including Peutz-Jeghers phenotype. 38
22987620 2012
13
A case of an extremely large accessory bone with unusual sutures and foramina parietalia permagna in multiple premature craniosynostoses. 38
22075323 2012
14
Tbx1 regulates oral epithelial adhesion and palatal development. 38
22371266 2012
15
Oral findings in Midline Syndrome: a case report and literature review. 38
20173721 2010
16
Partial adenoidectomy by suction diathermy in children with cleft palate, to avoid velopharyngeal insufficiency. 38
19740554 2009
17
Solitary median maxillary central incisor syndrome occurring together with oromandibular-limb hypogenesis syndrome type 1: a case report of this previously unreported combination of syndromes. 38
18328045 2008
18
[Numeric quantification of intelligibility in schoolchildren with isolated and combined cleft palate]. 38
17943262 2007
19
Endoscopic adenoidectomy in children with submucosal cleft palate. 38
16911833 2006
20
Chromosome 22q11 deletions in patients with conotruncal heart defects. 38
16132309 2005
21
Rapp-Hodgkin syndrome. 38
15748593 2004
22
[Small deletion--large effect]. 38
15004686 2004
23
Posterior chorioretinal atrophy and vitreous phenotype in a family with Stickler syndrome from a mutation in the COL2A1 gene. 38
12511349 2003
24
22q11.2 Deletion Syndrome 38
20301696 1999
25
Child with velocardiofacial syndrome and del (4)(q34.2): another critical region associated with a velocardiofacial syndrome-like phenotype. 38
10051168 1999
26
A lethal osteochondrodysplasia with mesomelic brachymelia, round pelvis, and congenital hepatic fibrosis: two siblings born to consanguineous parents. 38
9426272 1998
27
[Lens coloboma and lens dislocation in Stickler (Marshall) syndrome]. 38
9235398 1997
28
[Tooth and jaw development in the Silver-Russel syndrome]. 38
2286353 1990
29
Ocular hypotelorism, submucosal cleft palate, and hypospadias: a new autosomal dominant syndrome. 38
3149147 1988
30
[Perforation of the submucosal cleft palate]. 38
3866666 1985
31
Effects of maxillary advancement on the speech of a submucosal cleft palate patient. 38
267529 1977
32
[Klippel-Feil syndrome with coexistant submucosal cleft palate and hypoacusia]. 38
4522194 1974
33
[Submucosal cleft palate]. 38
13483223 1957

Variations for Submucosal Cleft Palate

Expression for Submucosal Cleft Palate

Search GEO for disease gene expression data for Submucosal Cleft Palate.

Pathways for Submucosal Cleft Palate

GO Terms for Submucosal Cleft Palate

Biological processes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.62 UBB GRHL3

Sources for Submucosal Cleft Palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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