MCID: SBM006
MIFTS: 14

Submucosal Cleft Palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Submucosal Cleft Palate

MalaCards integrated aliases for Submucosal Cleft Palate:

Name: Submucosal Cleft Palate 59

Classifications:



External Ids:

Orphanet 59 ORPHA155878
ICD10 via Orphanet 34 Q35.9

Summaries for Submucosal Cleft Palate

MalaCards based summary : Submucosal Cleft Palate is related to cleft palate, isolated and schilbach-rott syndrome. An important gene associated with Submucosal Cleft Palate is UBB (Ubiquitin B). Related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Submucosal Cleft Palate

Diseases related to Submucosal Cleft Palate via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cleft palate, isolated 29.0 GRHL3 UBB
2 schilbach-rott syndrome 11.4
3 otopalatodigital syndrome, type ii 11.1
4 hypospadias 9.9
5 uvula, bifid 9.4 GRHL3 UBB
6 cleft hard palate 9.3 GRHL3 UBB
7 cleft soft palate 9.2 GRHL3 UBB

Graphical network of the top 20 diseases related to Submucosal Cleft Palate:



Diseases related to Submucosal Cleft Palate

Symptoms & Phenotypes for Submucosal Cleft Palate

GenomeRNAi Phenotypes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.62 GRHL3 UBB

Drugs & Therapeutics for Submucosal Cleft Palate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal Completed NCT00773994 Not Applicable

Search NIH Clinical Center for Submucosal Cleft Palate

Genetic Tests for Submucosal Cleft Palate

Anatomical Context for Submucosal Cleft Palate

Publications for Submucosal Cleft Palate

Articles related to Submucosal Cleft Palate:

# Title Authors Year
1
Perforation With Submucosal Cleft Palate in a Previously Undiagnosed Adult Patient. ( 27526237 )
2016
2
Congenital Fistula of the Hard Palate With Submucosal Cleft Palate. ( 27391507 )
2016
3
Powered instrumentation for transnasal endoscopic partial adenoidectomy in children with submucosal cleft palate. ( 24373587 )
2014
4
An unusual accessory mandible and a submucosal cleft palate-a case report and review of the literature. ( 22404912 )
2013
5
Endoscopic adenoidectomy in children with submucosal cleft palate. ( 16911833 )
2006
6
Ocular hypotelorism, submucosal cleft palate, and hypospadias: a new autosomal dominant syndrome. ( 3149147 )
1988
7
Effects of maxillary advancement on the speech of a submucosal cleft palate patient. ( 267529 )
1977

Variations for Submucosal Cleft Palate

Expression for Submucosal Cleft Palate

Search GEO for disease gene expression data for Submucosal Cleft Palate.

Pathways for Submucosal Cleft Palate

GO Terms for Submucosal Cleft Palate

Biological processes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.62 GRHL3 UBB

Sources for Submucosal Cleft Palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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