MCID: SBM006
MIFTS: 15

Submucosal Cleft Palate

Categories: Fetal diseases, Rare diseases

Aliases & Classifications for Submucosal Cleft Palate

MalaCards integrated aliases for Submucosal Cleft Palate:

Name: Submucosal Cleft Palate 60

Classifications:



External Ids:

ICD10 via Orphanet 35 Q35.9
Orphanet 60 ORPHA155878

Summaries for Submucosal Cleft Palate

MalaCards based summary : Submucosal Cleft Palate is related to cleft palate, isolated and schilbach-rott syndrome. An important gene associated with Submucosal Cleft Palate is UBB (Ubiquitin B). The drug Cocaine has been mentioned in the context of this disorder. Related phenotype is Negative genetic interaction between PTTG1-/- and PTTG1+/+.

Related Diseases for Submucosal Cleft Palate

Diseases related to Submucosal Cleft Palate via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 cleft palate, isolated 29.9 GRHL3 UBB
2 schilbach-rott syndrome 11.6
3 otopalatodigital syndrome, type ii 11.3
4 hypospadias 10.0
5 hard palate cancer 10.0
6 uvula, bifid 9.7 GRHL3 UBB
7 cleft hard palate 9.7 GRHL3 UBB
8 cleft soft palate 9.6 GRHL3 UBB

Graphical network of the top 20 diseases related to Submucosal Cleft Palate:



Diseases related to Submucosal Cleft Palate

Symptoms & Phenotypes for Submucosal Cleft Palate

GenomeRNAi Phenotypes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Negative genetic interaction between PTTG1-/- and PTTG1+/+ GR00255-A-4 8.62 GRHL3 UBB

Drugs & Therapeutics for Submucosal Cleft Palate

Drugs for Submucosal Cleft Palate (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cocaine Approved, Illicit Not Applicable 50-36-2 446220 5760

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study Evaluating Characteristic Closure Patterns of the Normal Velopharyngeal Portal Completed NCT00773994 Not Applicable
2 Exercises for Improving Soft Palate and Eustachian Tube Function in Children With Ear Tubes With or Without Cleft Palate Not yet recruiting NCT03868891 Not Applicable

Search NIH Clinical Center for Submucosal Cleft Palate

Genetic Tests for Submucosal Cleft Palate

Anatomical Context for Submucosal Cleft Palate

Publications for Submucosal Cleft Palate

Articles related to Submucosal Cleft Palate:

# Title Authors Year
1
Congenital Fistula of the Hard Palate With Submucosal Cleft Palate. ( 27391507 )
2016
2
Perforation With Submucosal Cleft Palate in a Previously Undiagnosed Adult Patient. ( 27526237 )
2016
3
Powered instrumentation for transnasal endoscopic partial adenoidectomy in children with submucosal cleft palate. ( 24373587 )
2014
4
An unusual accessory mandible and a submucosal cleft palate-a case report and review of the literature. ( 22404912 )
2013
5
Endoscopic adenoidectomy in children with submucosal cleft palate. ( 16911833 )
2006
6
Ocular hypotelorism, submucosal cleft palate, and hypospadias: a new autosomal dominant syndrome. ( 3149147 )
1988
7
Effects of maxillary advancement on the speech of a submucosal cleft palate patient. ( 267529 )
1977

Variations for Submucosal Cleft Palate

Expression for Submucosal Cleft Palate

Search GEO for disease gene expression data for Submucosal Cleft Palate.

Pathways for Submucosal Cleft Palate

GO Terms for Submucosal Cleft Palate

Biological processes related to Submucosal Cleft Palate according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 8.62 GRHL3 UBB

Sources for Submucosal Cleft Palate

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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