MCID: SBM005
MIFTS: 21

Submucous Uterine Fibroid

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Submucous Uterine Fibroid

MalaCards integrated aliases for Submucous Uterine Fibroid:

Name: Submucous Uterine Fibroid 12 15
Submucous Leiomyoma of Uterus 12 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:13222
ICD9CM 35 218.0
SNOMED-CT 68 95279007
ICD10 33 D25.0
UMLS 72 C0153993

Summaries for Submucous Uterine Fibroid

Disease Ontology : 12 An uterine fibroid that is located adjacent to the lining of the uterus.

MalaCards based summary : Submucous Uterine Fibroid, also known as submucous leiomyoma of uterus, is related to leiomyoma and myofibroma. An important gene associated with Submucous Uterine Fibroid is IGFBP1 (Insulin Like Growth Factor Binding Protein 1). The drugs Misoprostol and Alprostadil have been mentioned in the context of this disorder. Affiliated tissues include uterus.

Related Diseases for Submucous Uterine Fibroid

Diseases related to Submucous Uterine Fibroid via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leiomyoma 10.5
2 myofibroma 10.5
3 ectopic pregnancy 10.2
4 infertility 10.2
5 syncope 10.2
6 endometrial cancer 9.7 PAEP IGFBP1

Comorbidity relations with Submucous Uterine Fibroid via Phenotypic Disease Network (PDN):


Female Stress Incontinence Subserous Uterine Fibroid

Graphical network of the top 20 diseases related to Submucous Uterine Fibroid:



Diseases related to Submucous Uterine Fibroid

Symptoms & Phenotypes for Submucous Uterine Fibroid

Drugs & Therapeutics for Submucous Uterine Fibroid

Drugs for Submucous Uterine Fibroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 2, Phase 3 59122-46-2 5282381
2
Alprostadil Approved, Investigational Phase 2, Phase 3 745-65-3 5280723 149351
3 Gastrointestinal Agents Phase 2, Phase 3
4 Pharmaceutical Solutions Phase 2, Phase 3
5 Antacids Phase 2, Phase 3
6 Natriuretic Agents Phase 2, Phase 3
7 Coagulants Phase 2, Phase 3
8 Oxytocics Phase 2, Phase 3
9 Hemostatics Phase 2, Phase 3
10 arginine Phase 2, Phase 3
11 Anti-Ulcer Agents Phase 2, Phase 3
12 Vasoconstrictor Agents Phase 2, Phase 3
13 Vasopressins Phase 2, Phase 3
14 Arginine Vasopressin Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial. Completed NCT03930069 Phase 2, Phase 3 Misoprostol;Vasopressin

Search NIH Clinical Center for Submucous Uterine Fibroid

Genetic Tests for Submucous Uterine Fibroid

Anatomical Context for Submucous Uterine Fibroid

MalaCards organs/tissues related to Submucous Uterine Fibroid:

41
Uterus

Publications for Submucous Uterine Fibroid

Articles related to Submucous Uterine Fibroid:

# Title Authors PMID Year
1
Submucous uterine fibroid mimicking ruptured ectopic gestation: a case report. 38
25177608 2014
2
Decreasing bleeding due to uterine fibroid with electroacupuncture. 38
21561613 2011
3
Management of submucous uterine fibroid with buserelin, gemeprost and hysteroscopic resection. 38
1899715 1991

Variations for Submucous Uterine Fibroid

Expression for Submucous Uterine Fibroid

Search GEO for disease gene expression data for Submucous Uterine Fibroid.

Pathways for Submucous Uterine Fibroid

GO Terms for Submucous Uterine Fibroid

Cellular components related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.13 SPP1 PAEP IGFBP1
2 endoplasmic reticulum lumen GO:0005788 8.62 SPP1 IGFBP1

Biological processes related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 8.96 SPP1 IGFBP1
2 cellular protein metabolic process GO:0044267 8.62 SPP1 IGFBP1

Sources for Submucous Uterine Fibroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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