MCID: SBM005
MIFTS: 30

Submucous Uterine Fibroid

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Submucous Uterine Fibroid

MalaCards integrated aliases for Submucous Uterine Fibroid:

Name: Submucous Uterine Fibroid 12 15
Submucous Leiomyoma of Uterus 12 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13222
ICD9CM 34 218.0
SNOMED-CT 67 95279007
ICD10 32 D25.0
UMLS 71 C0153993

Summaries for Submucous Uterine Fibroid

Disease Ontology : 12 An uterine fibroid that is located adjacent to the lining of the uterus.

MalaCards based summary : Submucous Uterine Fibroid, also known as submucous leiomyoma of uterus, is related to ectopic pregnancy and infertility. An important gene associated with Submucous Uterine Fibroid is OS9 (OS9 Endoplasmic Reticulum Lectin), and among its related pathways/superpathways are PAK Pathway and JAK-STAT signaling pathway (KEGG). The drugs Alprostadil and Misoprostol have been mentioned in the context of this disorder. Affiliated tissues include uterus, and related phenotypes are Decreased ionizing radiation sensitivity and reproductive system

Related Diseases for Submucous Uterine Fibroid

Graphical network of the top 20 diseases related to Submucous Uterine Fibroid:



Diseases related to Submucous Uterine Fibroid

Symptoms & Phenotypes for Submucous Uterine Fibroid

GenomeRNAi Phenotypes related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased ionizing radiation sensitivity GR00232-A-1 9.17 HOXA10 HOXA11 IGFBP1 IL10 LIF PAEP

MGI Mouse Phenotypes related to Submucous Uterine Fibroid:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.5 GNRH1 HOXA10 HOXA11 IL10 LIF SPP1
2 skeleton MP:0005390 9.23 BMPR2 GNRH1 HOXA10 HOXA11 IL10 LIF

Drugs & Therapeutics for Submucous Uterine Fibroid

Drugs for Submucous Uterine Fibroid (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alprostadil Approved, Investigational Phase 2, Phase 3 745-65-3 149351 5280723
2
Misoprostol Approved Phase 2, Phase 3 59122-46-2 5282381
3 Gastrointestinal Agents Phase 2, Phase 3
4 Natriuretic Agents Phase 2, Phase 3
5 Oxytocics Phase 2, Phase 3
6 Vasoconstrictor Agents Phase 2, Phase 3
7 Anti-Ulcer Agents Phase 2, Phase 3
8 Pharmaceutical Solutions Phase 2, Phase 3
9 Hemostatics Phase 2, Phase 3
10 Coagulants Phase 2, Phase 3
11 Arginine Vasopressin Phase 2, Phase 3
12 Vasopressins Phase 2, Phase 3
13 Antacids Phase 2, Phase 3
14
Arginine Investigational, Nutraceutical Phase 2, Phase 3 74-79-3 6322

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Transcervical Vasopressin Injection VersusVaginal Misoprostol During Hysteroscopic Myomectomy in Reducing Operative Blood Loss and Operation Time: A Randomized Trial. Completed NCT03930069 Phase 2, Phase 3 Misoprostol;Vasopressin

Search NIH Clinical Center for Submucous Uterine Fibroid

Genetic Tests for Submucous Uterine Fibroid

Anatomical Context for Submucous Uterine Fibroid

MalaCards organs/tissues related to Submucous Uterine Fibroid:

40
Uterus

Publications for Submucous Uterine Fibroid

Articles related to Submucous Uterine Fibroid:

# Title Authors PMID Year
1
Submucous uterine fibroid mimicking ruptured ectopic gestation: a case report. 61
25177608 2014
2
Decreasing bleeding due to uterine fibroid with electroacupuncture. 61
21561613 2011
3
Management of submucous uterine fibroid with buserelin, gemeprost and hysteroscopic resection. 61
1899715 1991

Variations for Submucous Uterine Fibroid

Expression for Submucous Uterine Fibroid

Search GEO for disease gene expression data for Submucous Uterine Fibroid.

Pathways for Submucous Uterine Fibroid

Pathways related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.79 LIF IL11 IL10 GNRH1 BMPR2
2
Show member pathways
11.7 LIF IL11 IL10
3 11.28 WNT4 LIF BMPR2
4 10.72 IL11 IL10
5 9.92 SPP1 LIF IL11 IL10 GNRH1

GO Terms for Submucous Uterine Fibroid

Cellular components related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 WNT4 SPP1 PAEP LIF IL11 IL10
2 endoplasmic reticulum lumen GO:0005788 9.46 WNT4 SPP1 OS9 IGFBP1
3 extracellular space GO:0005615 9.23 WNT4 SPP1 LIF IL11 IL10 IGFBP1

Biological processes related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 LIF IL11 IL10 HOXA10 BMPR2 ADIRF
2 multicellular organism development GO:0007275 9.73 WNT4 PAEP LIF HOXA11 HOXA10 GNRH1
3 aging GO:0007568 9.69 IL10 IGFBP1 GNRH1
4 anterior/posterior pattern specification GO:0009952 9.61 HOXA11 HOXA10 BMPR2
5 embryo implantation GO:0007566 9.58 SPP1 LIF
6 male gonad development GO:0008584 9.58 WNT4 HOXA11 HOXA10
7 positive regulation of bone mineralization GO:0030501 9.57 WNT4 BMPR2
8 lung alveolus development GO:0048286 9.56 LIF BMPR2
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.55 IL11 IL10
10 response to steroid hormone GO:0048545 9.54 SPP1 GNRH1
11 blood vessel remodeling GO:0001974 9.52 LIF BMPR2
12 decidualization GO:0046697 9.49 SPP1 LIF
13 proximal/distal pattern formation GO:0009954 9.48 HOXA11 HOXA10
14 uterus development GO:0060065 9.46 HOXA11 HOXA10
15 negative regulation of hormone secretion GO:0046888 9.37 LIF IL11
16 endothelial cell apoptotic process GO:0072577 9.16 IL10 BMPR2
17 regulation of complement-dependent cytotoxicity GO:1903659 8.96 IL11 IL10
18 regulation of gene expression GO:0010468 8.92 IL10 HOXA11 HOXA10 GNRH1

Molecular functions related to Submucous Uterine Fibroid according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 LIF IL11 IL10
2 cytokine activity GO:0005125 8.92 SPP1 LIF IL11 IL10

Sources for Submucous Uterine Fibroid

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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